Podcasts about Sakaguchi

En este capitulo celebramoe el 15 aniversario del Banquete con una transmisón muy especial desde el Museo Casa del Risco, en San Ángel. Estuvimos acompañados de nuestro querido "fresco" Emilio Montes de Oca, Andrea Borbolla, quien será nuestra próxima Cheff, que unirá a esta cocina, una entrevista con la Directora del museo Gabriela López, que nos habló del orígen de tan espectacular Casa museo. Nuestros invitados de honor, Óscar Sakaguchi "el soldado del amor", José Luis Calderón, Ricardo Yahuaca, y todos los comensales que nos acompañaron en éste día tan especial. #Sapereaude/Atreveteasaber.See omnystudio.com/listener for privacy information.

This week, Rick is joined by Ryan (List Off Podcast) to discuss Final Fantasy, the place where the series started - for some in the late 80s, and for others in 2025! It's part discussion on how the experience can still feel exciting today, and part reflection on a genre and series that means so much to so many. Please enjoy!Click on the following to find PPR on the web!PatreonJoin our DiscordBlueskyInstagram TikTokThank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Episode 115: In this episode of Critical Thinking - Bug Bounty Podcast Justin and So Sakaguchi sit down to walk through some recent bugs, before having a live mentorship session. They also talk about Reflector, and finish up by doing a bonus podcast segment in Japanese!Follow us on twitter at: https://x.com/ctbbpodcastGot any ideas and suggestions? Feel free to send us any feedback here: info@criticalthinkingpodcast.ioShoutout to https://x.com/realytcracker for the awesome intro music!====== Links ======Follow your hosts Rhynorater and Rez0 on Twitter: https://x.com/Rhynoraterhttps://x.com/rez0__====== Ways to Support CTBBPodcast ======Hop on the CTBB Discord at https://ctbb.show/discord!We also do Discord subs at $25, $10, and $5 - premium subscribers get access to private masterclasses, exploits, tools, scripts, un-redacted bug reports, etc.You can also find some hacker swag at https://ctbb.show/merch!Today's Sponsor: ThreatLocker Cloud Control - https://www.threatlocker.com/platform/cloud-controlToday's Guest: https://x.com/Mokusou4====== Resources ======So's last appearance in episode 40ctbb.show/40====== Timestamps ======(00:00:00) Introduction(00:04:11) So's Facebook Bug(00:14:37) So and Justin's Google Bug(00:33:39) Live Mentorship Session(00:56:29) Reflector(01:13:22) Bonus - Podcast in Japanese

Jared and Anne Ladyem (anneladyem.com) check out what's up with the latest game from Hironobu Sakaguchi and how the expanded version of the game reunited Sakaguchi and Square Enix for the first time in over twenty years, thanks in large part to a video game called Final Fantasy XIV.

The creator of one of our collective favorite franchises has finally released his latest game out of Apple Arcade jail...but did it live up to our expectations? Join us as we discuss questionable design choices, difficult boss fights, and how much better Final Fantasy VI was over 30 years ago.Note: The music track at the start of the episode is “Cinderella Tri-Stars”, composed by Nobuo Uematsu for the Fantasian Original Soundtrack. We in no way have or claim ownership of this music.Sakaguchi's Interview with The Verge: https://www.theverge.com/2025/1/24/24350575/hironobu-sakaguchi-interview-fantasian-neo-dimensionSupport the showEmail us at: dcellmedia@gmail.com

Support ⁠⁠⁠⁠⁠Nintendo Pow Block & Boss Rush on Patreon⁠⁠⁠ This week on Nintendo Pow Block, Stephanie Klimov joins Edward and Corey to discuss a recent interview with Yuji Horii sharing Dragon Quest XII updates, Hironobu Sakaguchi's new dark fantasy game following Fantasian: Neo Dimension, and rumors of Xbox titles like Forza Horizon 5 coming to Switch 2. They also cover Fantasy Life i possibly launching on PlayStation, leaks about Switch 2 game cases, and its confirmed backward compatibility. To wrap up, they answer community questions on Xbox's multiplatform strategy, third-party support for Switch 2, and recent Nintendo Switch Online updates. Time Stamps: 0:00 - Welcome to Nintendo Pow Block 8:58 - Housekeeping 13:55 - Snacktendo! 26:17 - Playing With Power 56:56 - Weekly Pickups 1:04:58 - FamiNEWS! 1:05:28 - Sakaguchi's New Dark Fantasy Game 1:12:41 - Fantasy Life i: The Girl Who Steals Time 1:21:31 - Shovel Knight is Back in Yooka-Laylee Remaster 1:22:51 - Another Week, Another Xbox on Switch 2 Rumor 1:36:48 - Switch 2 Box Sizes May Have Leaked 1:38:25 - PAK Watch! 1:50:39 - Question Block! Community Write-Ins 1:51:29 - Benefits of Xbox on Switch 2 for Both 1:58:19 - Major Third Party Franchise on Switch 2 2:06:15 - Are Recent NSO Updates Enough? 2:11:56 - Final Thoughts 2:16:06 - Thanks for Watching Playing with Power: de Blob, de Blob 2, Disney Dreamlight Valley, Disney Speedstorm, Donkey Kong Country Returns HD, Forza Horizon 4 (Xbox), Game Builder Garage, Okami HD, Pokemon Trading Card Game Pocket (Mobile), Super Mario Party Jamboree, Vampire Survivors Weekly Pickups: Earthbound Strategy Guide, Super Mario Party Jamboree, WarioWare: Get It Together Be a Part of our Community! Community: Join the ⁠⁠⁠⁠⁠⁠⁠Boss Rush Discord⁠⁠⁠⁠⁠⁠⁠ Subscribe ⁠⁠⁠⁠⁠⁠on YouTube⁠⁠⁠⁠⁠⁠ Follow our Hosts: Edward Varnell: ⁠⁠⁠⁠⁠X/Twitter⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠ Corey Dirrig: ⁠⁠⁠⁠⁠X/Twitter⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠Bluesky⁠⁠⁠ Stephanie Klimov: X/Twitter, Bluesky Thank you for watching and/or listening to Nintendo Pow Block, the Nintendo podcast for Boss Rush Media and The Boss Rush Network. If you enjoyed the discussion, subscribe and like the video, leave a comment, and hit the bell so you don't miss an episode. If you listen on Apple Podcasts or Spotify, remember to leave us a five star rating and a nice review. You can support Nintendo Pow Block and Boss Rush on Patreon at any tier. Thanks for watching or listening to Nintendo Pow Block and supporting The Boss Rush Network's independent endeavor. It means more than you know.

On this episode of Punching Up Brad, Gene, Micah, and Dustin talk about the unexpected Xenoblade Chronicles X: Definitive Edition, Nintendo Music, updated Nintendo financials, and more! Please keep in mind that our timestamps are approximate, and will often be slightly off due to dynamic ad placement. 0:00:00 - Intro 0:16:16 - Xenoblade Chronicles X: Definitive Edition announced 0:32:42 - Nintendo Music 0:38:38 - Switch sales stuff 0:53:18 - Mario and Luigi Brothership 1:00:27 - What we're playing 1:29:21 - Dragon Age spoiler start 1:31:01 - Spoiler end 1:43:51 - Persona series sales 1:47:37 - Splatoon 3 roadmap 1:51:14 - Sakaguchi working on new Dark Fantasy game 1:53:49 - Ending questions Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Lillian Siu and Dr. Melvin Chua discuss the new technologies and novel therapeutics that were featured at the 2024 ASCO Breakthrough meeting. TRANSCRIPT Dr. Lillian Siu: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Lillian Siu, a medical oncologist and director of the Phase 1 Trials Program at the Princess Margaret Cancer Center in Toronto, Canada, and a professor of medicine at the University of Toronto. On today's episode, we'll be discussing key takeaways from the 2024 ASCO Breakthrough meeting in Yokohama, Japan. Joining me for this discussion is Dr. Melvin Chua, who served as the chair of Breakthrough's Program Committee. Dr. Chua is the head of the Department for Head, Neck and Thoracic Cancers in the Division of Radiation Oncology at the National Cancer Center in Singapore. Our full disclosures are available in the transcript of this episode. Dr. Chua, it's great to be speaking with you today and congratulations on a very successful Breakthrough meeting. Dr. Melvin Chua: Thanks Dr. Siu. It was really inspiring to come together again to showcase the innovative work of world-renowned experts, clinicians, researchers, med-tech pioneers, and drug developers from around the globe. Our theme this year was inclusivity and thus it was important to bring people together again in the Asia Pacific region and to foster international collaborations that are so important in advancing cancer care. This year, we invited 65 international faculty, of which 55% were from Asia. Also, importantly, we achieved approximately a 50-50 split for male to female representation. These are remarkable statistics for the meeting, and we really hope to retain this for future Breakthrough [meetings]. Dr. Lillian Siu: The meeting featured renowned keynote speakers who shared great insights on new technologies and therapies that are shaping the future of drug development and care delivery. Let's first talk about artificial intelligence and the keynote address by Dr. Andrew Trister. He gave a very interesting talk titled, “Plaiting the Golden Braid: How Artificial Intelligence Informs the Learning Health System.” What are the key messages from his talk? Dr. Melvin Chua: Couldn't agree with you more, Dr. Siu. Dr. Trister is the chief medical and scientific officer of Verily, a precision health company. He previously worked in digital health and AI at The Bill and Melinda Gates Foundation, and worked at Apple where he led clinical research and machine learning with Apple partners. But perhaps it was really his background and training as a radiation oncologist that was most pertinent as he was able to weave both the components of new AI models and the applications and pitfalls in the clinic to the audience. Dr. Trister provided a very high-level view through the history of AI and showcased the progression of the different AI models and he basically explained between deep and shallow methods as well as deductive logic versus inductive probabilistic methods. He then provided several clinical examples where these models have shown their utility in the clinic, for example, pathology and so forth. At the same time, he illustrated several pitfalls with these models. So overall, I think Dr. Trister's talk was very well received by the audience with several key messages, including the importance of [using] high-quality data as the basis of a good AI model. AI was also addressed in an Education Session that looked at Artificial Intelligence in the Cancer Clinic. And we had a panel of experts that highlighted current progress and successes with AI in the clinic, advances with AI assisted pathology for clinical research and precision medicine, large language models (LLMs) for applications in the clinic, and how we could leverage AI in precision oncology. And from this session, I had several key takeaways. Dr. Alexander Pearson [of the University of Chicago] gave a very illustrative talk on how multimodal information across clinical omics, radiological information and multi omics could be used to improve diagnostic tasks and clinical prediction across different cancers. And Dr. Joe Yeong [of Singapore General Hospital] gave a very good talk on how AI can be applied in digital pathology to accelerate research in immunology and help in the development of immunotherapies. Dr. Danielle Bitterman [of Brigham and Women's Hospital] shared very good examples of how LLMs could be used in a clinic. And I think the example that really stood out for me was how LLMs could be deployed to create responses to patient queries. And of course, the big question in the room was: How could AI eventually encapsulate compassion in their response? I think this again showcased how LLMs could really help to accelerate our clinical work going forward. And ultimately circling back to data, Dr. Caroline Chung [of MD Anderson] gave a very poignant description on the importance of data quality and how poor-quality data could eventually lead to underperforming AI models. So all in all, I think this was a great session. And what do you think, Dr. Siu? Dr. Lillian Siu: Melvin, I totally agree with you. I like all your comments and I really enjoyed the keynote as well as the session on AI in the cancer clinic chaired by Dr. Pearson. I think all these sessions were really informative. Discussions on the latest AI and machine learning, algorithms and technologies on digital pathology, LLMs and big data, as you said, really enables the attendees, especially clinicians like me, to gain a deep understanding of how AI can be translated to practical applications. Dr. Melvin Chua: Great. So, Dr. Siu, let's talk about some of the novel therapeutics that were featured at the meeting. Again, this was an important session for Breakthrough, and it's always been there. So could you share some highlights from the sessions on novel drug development from your perspective? Dr. Lillian Siu: Yes, indeed. Drug development is such an exciting aspect of this meeting. On Day 3 of the meeting, we had a keynote by Dr. Shimon Sakaguchi of Osaka University, who discussed “Targeting Regulatory T cells (Tregs) in Cancer: The Science, Trials, and Future.” And he talked about T cells, especially Treg biology, the role of Tregs in immune regulation, new developments in Treg immuno-oncology drugs, and how we can actually target Tregs to treat early cancers, etc. This talk is particularly exciting because there are now anti CCR8 antibodies in the clinic that specifically target Tregs, and some early signals of anti-tumor activities are already being observed. Dr. Sakaguchi also emphasized the importance of combination sequence and timing of drugs for the successful use of cancer immunotherapeutic agents. I also want to emphasize the Education Session that followed, titled, “The Future of Immunotherapy, New Drugs and New Ideas.” In that particular session, we heard about engineering T-cell immunity to eradicate tumors. We heard about CAR T-cell therapy in GI cancers, novel immunotherapeutic combinations, and T-cell engagers, which are bispecifics in cancer. While success with some of these immunotherapeutic modalities, such as cell therapies and T-cell engagers have been largely seen in hematological malignancies, we are beginning to observe efficacy signals in solid tumors. For example, the CAR T targeting Claudin18.2 in gastrointestinal cancers and the recently approved FDA-approved DLL3/CD3 bispecific T-cell engager, tarlatamab, in small cell lung cancer are really exciting examples. We also heard from investigators who are exploring neoadjuvant therapies in the neoadjuvant therapy session, and the key takeaway from that session is that we have growing interest in using neoadjuvant therapy or perioperative therapy. In other words, neoadjuvant plus adjuvant therapy in different cancers. In the neoadjuvant session, there were updates provided by different experts on the roles of neoadjuvant therapy in melanoma, liver cancer, bladder cancer, and nasopharyngeal cancer. Increasingly, there is randomized trial evidence to support the use of neoadjuvant therapy or perioperative immunotherapy in several cancer types with survival-based endpoints. Very exciting indeed. Dr. Melvin Chua: Indeed, I couldn't agree with you more. I think one of the things that went into designing the case-based discussions this year was that we wanted to talk about cancers that were relevant to this part of the world and hence we again showcased lung cancers, gastric cancers and melanomas, and whereby we have again perspectives from an expert from the West coupled to an expert from the East, thereby showcasing the diversity of practice around the world. The other thing that we did this year was we decided to pair the case-based discussions with the keynotes and the Education Sessions as well. For example, on Day 3, we had Dr. Sakaguchi speak on Tregs, as you mentioned. And this was followed by an in-depth session on new immunotherapies, and then followed by a case-based discussion on different melanoma cases on the role of neoadjuvant immunotherapy in this disease, and the strikingly relevance of response to prognostication. This is an important trait that we're seeing now that seems to pan out across different cancers, where we find that neoadjuvant response to combination systemic therapies and/or radiotherapy is a strong prognosticator. Dr. Lillian Siu: So, Dr. Chua, we've discussed some breakthrough treatments and promising advances in cancer care, and we've touched upon some barriers to success in cancer treatment. I would like to ask you about the keynote address by Dr. Raffaella Casolino of the World Health Organization, who spoke passionately about efforts by the WHO and its partners to build equity in cancer care. Can you share some highlights with us? Dr. Melvin Chua: Absolutely, Dr. Siu. In spite of the tremendous advances we've seen in recent years in oncology, there are still major disparities in cancer care, such as cost and access, which affect patients worldwide. I think Dr. Casolino's talk was a very nice overview whereby she showed, first of all, the WHO's impact in terms of the WHO Cancer Resolution initiative that was implemented in 2017, where through this initiative, WHO has impacted 100 countries, invested $1 billion in funds, and that has led to millions of lives saved. But she then really drilled down to some of the key examples of the focus of the WHO in terms of equalizing care in cancer. I think one which struck me was the appreciation of the disparities in the clinical trials landscape. I think it is clear that there's still a huge barrier to clinical trials between the high- and middle-income countries and the low- and middle-income countries, and the majority of clinical trials these days are industry sponsored and we really need to look at leveling the playing field in this regard. Then she highlighted the WHO's work on trying to lower the barriers to precision oncology. And I think there are several issues in that sense, but I think what the WHO has really worked hard on is promoting education for genomic medicine, where they've done several reviews with experts around the world to educate the field across the world on how we interpret and apply genomics in the clinic. So all in all, it was very interesting to hear Dr. Casolino's insights from a policy perspective, and again, this emphasizes that there's so much work to be done at the end of the day and the dialogue needs to continue. We also heard about policy, academic and industry perspectives in the context of clinical trials, and that led to a discussion on real-world evidence generation for regulatory approvals. It was very nice that we had a session on that at the end of Breakthrough 2024 (Real-World Evidence and Clinical Trials: Beyond the Ivory Tower). And in that session, we heard from Dr. Shaalan Beg [of the NIH], and Dr. Janet Dancey [of Queen's University] who represented views from academia and Dr. Hidetoshi Hayashi [of Kindai University Hospital] shared perspectives on decentralized trials. I'd like to encourage our listeners to watch these sessions if they were unable to attend. The content is very rich, and I'm sure they'll learn from it. Dr. Lillian Siu: Thank you so much, Dr. Chua. Is there anything else you would like to cover before we wrap up the podcast today? Dr. Melvin Chua: Thank you, Dr. Siu. The thing I really want to emphasize is, apart from all these Educational Sessions and having very eminent keynote speakers, one of the key points that we really want to bring out for Breakthrough is to showcase the high-quality research. This year we had 300 abstracts submitted and they were all high quality, cutting across trials, omics research, AI and technology, and eventually we selected 235 of them and we were able to showcase some of them across three oral sessions over three days. I think this is an important component of Breakthrough that we really wish to continue building upon where people are now excited to use this forum to present their work. Dr. Lillian Siu: Thank you so much, Dr. Chua. I really enjoyed our discussions today. I look forward to seeing how the Breakthrough meeting will continue to grow in future years. Dr. Melvin Chua: Thank you again, Dr. Siu. Thank you for all your leadership and efforts in making Breakthrough a successful meeting series the past few years. Dr. Lillian Siu: Thank you to our listeners for your time today. You'll find links to the session discussed today in the transcript of this episode. Finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review and subscribe wherever you get your podcast. Thank you.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:   Dr. Lilian Siu  @lillian_siu  Dr. Melvin Chua  @DrMLChua    Follow ASCO on social media:    @ASCO on Twitter    ASCO on Facebook    ASCO on LinkedIn      Disclosures:   Dr. Lillian Siu:  Leadership (Immediate family member): Treadwell Therapeutics  Stock and Other Ownership Interests (Immediate family member): Agios    Consulting or Advisory Role: Merck, AstraZeneca/MedImmune, Roche, Voronoi Inc., Oncorus, GSK, Seattle Genetics, Arvinas, Navire, Janpix, Relay Therapeutics, Daiichi Sankyo/UCB Japan, Janssen, Research Funding (Institution): Bristol-Myers Squibb, Genentech/Roche, GlaxoSmithKline, Merck, Novartis, Pfizer, AstraZeneca, Boehringer Ingelheim, Bayer, Amgen, Astellas Pharma, Shattuck Labs, Symphogen, Avid, Mirati Therapeutics, Karyopharm Therapeutics, Amgen   Dr. Melvin Chua:  Leadership, Stock and Other Ownership Interests: Digital Life Line  Honoraria: Janssen Oncology, Varian  Consulting or Advisory Role: Janssen Oncology, Merck Sharp & Dohme, ImmunoSCAPE, Telix Pharmaceuticals, IQVIA, BeiGene  Speakers' Bureau: AstraZeneca, Bayer, Pfizer, Janssen   Research Funding: PVmed, Decipher Biosciences, EVYD Technology, MVision, BeiGene, EVYD Technology, MVision, BeiGene  Patents, Royalties, Other Intellectual Property: High Sensitivity Lateral Flow Immunoassay for Detection of Analyte in Samples (10202107837T), Singapore. (Danny Jian Hang Tng, Chua Lee Kiang Melvin, Zhang Yong, Jenny Low, Ooi Eng Eong, Soo Khee Chee)    

¡Ya está aquí vuestra ración semanal de vuestro podcast favorito! Con la participación de: ✔️ Juan Tejerina · @jtvillamuera ✔️ Ramiro Díez · @Ramisfactions ✔️ Juan Pedro Prat · @JuanpePrat_ ✔️ Javier Bello · @Javi_B_C ✔️ Dan Puerta al Sótano · @dan_chaos ✔️ Yugita-Chan · @YugitaChan Intro musical de GTM Restart creada por Pitypob · @pitypob2 ✌ Cuña publicitaria cortesía de Javier Ruíz · @javucho_3 ⚙️ Edición y Montaje: Javier Bello · @Javi_B_C GTM LINKTREE: https://linktr.ee/gtmediciones *Canal de Yugita-chan*: https://www.youtube.com/@YugitaChan *Canal de Dan*: https://www.youtube.com/@Dan-PuertaAlSotano Micrófonos Pulse gracias al apoyo de NZXT https://nzxt.com/en-DE ================ ACTUALIDAD - Nintendo quiere preparar suficiente stock de su próxima consola para combatir la especulación. - Resident Evil 9 estará dirigido por Koshi Nakanishi, el director de RE7 y RE Revelations. - Tose, estudio outsourcing con multitud de codesarrollos a sus espaldas, afronta problemas financieros por la multitud de cancelaciones de proyectos de sus clientes. - Hironobu Sakaguchi vuelve a colaborar con Square Enix, pero no tiene interés en volver a ninguna de sus aclamadas IPs cómo Final Fantasy, Blue Dragon o Lost Odyssey. - Nintendo y el uso de la IA en el desarrollo de videojuegos. MELOCOTONAZOS "Asalto al Castillo" — BSO La Bella y la Bestia https://open.spotify.com/intl-es/track/4bl5ui7Z4tsLWTE8Yg3GDv?si=81068b01a929439b "Wildfire" — BSO Honkai Star Rail https://open.spotify.com/intl-es/track/2CUSdI74D2yqrvEXRQq2Xl RECTA FINAL - Como siempre, cerraremos hablando de los juegos que nos han ocupado esta semana junto con la ración de caspa rancia en la despedida. ================ 0:00 CUÑA PUBLICITARIA 0:56 INTRO 8:57 SWITCH 2 ESPECULACIÓN 26:30 RESIDENT EVIL 9 44:32 STUDIO TOSE FINANZAS 51:27 SAKAGUCHI Y SQUARE ENIX 1:07:18 NINTENDO VS IA 1:17:58 MELOCOTONAZO 1:21:36 RECTA FINAL ================ GTM (Games Tribune Magazine) 2024 @GamesTribune www.gamestribune.com

✩ Audio Version ✩ ► https://superderekrpgs.com/hitpoint/ SOCIAL LINKS --------------------------------------------------- ✩ Derek ✩ ►Twitter: https://twitter.com/SuperDerekRPGs ►Twitch: https://www.twitch.tv/SuperDerekRPGs ►Discord: https://discord.me/superderek✩ Baku ✩ ►Twitter: https://www.twitter.com/BakusanOG►Twitch: https://www.twitch.tv/BakusanOG►Youtube: https://www.youtube.com/WeebSauce ►Discord: https://discord.me/ABCUPCOMING RELEASES --------------------------------------------------- ►Until Thenhttps://www.youtube.com/watch?v=PQQgY2fVTOYn GAME ANNOUNCEMENTS --------------------------------------------------- ►Mario & Luigi: Brothershiphttps://www.youtube.com/watch?v=s5I3DcapElQ ►Fairy Tail 2https://www.youtube.com/watch?v=HSj9YwmaDxA ►Farmagiahttps://www.youtube.com/watch?v=JZlWDru2Xnk ►DQ I, II, and III HD2D Remakehttps://www.youtube.com/watch?v=IJoq6FWY-00 ►Phantom Brave: The Lost Herottps://www.youtube.com/watch?v=nuR3rUklk_I ►Marvel vs. Capcom Fighting Collection: Arcade Classicshttps://www.youtube.com/watch?v=ftcuw-MNHV8 ►The Legend of Zelda: Echoes of Wisdomhttps://www.youtube.com/watch?v=94RTrH2erPE ►Ace Attorney Investigations Collectionhttps://www.youtube.com/watch?v=PLFMaakr_xg►The Hundred Line: Last Defense Academyhttps://www.youtube.com/watch?v=UIe9HYH08eA ►Romancing SaGa 2: Revenge of the Sevenhttps://www.youtube.com/watch?v=SaNbHju85Ts ►Elrentaros Wanderingshttps://www.youtube.com/watch?v=R4X6iH1vaFc0:00:00 Welcome Back to Hit Point!0:01:12 Intro0:01:53 Baku how are you doing?0:05:36 Maybe no HitPoint next week? Last Week's Comments:0:08:32 Comment 1: "The Souls games give you tools to make the game easier..."0:12:15 Comment 2: "You manage to talk about Breath of Fire often..."0:14:22 Comment 3: "Given how many animal characters are in BoF..."0:18:16 Comment 4: "I love to break games..."0:19:42 Comment 4: "Personally, I absolutely hate it..."  Upcoming Releases This Week 0:24:14 Until Then New Game Announced:0:27:43 Mario & Luigi: Brothership - 07.11.20240:35:14 Fairy Tail 2 - This Winter0:44:18 FANTASIAN Neo Dimension - Holiday 20240:55:54 Farmagia - 01.11.20241:02:49 DRAGON QUEST III HD-2D - 14.11.2024 + DRAGON QUEST I & II HD-2D - 20251:17:22 Phantom Brave: The Lost Hero - 20251:22:54 Marvel vs. Capcom Fighting Collection: Arcade Classics - 20241:32:22 The Legend of Zelda: Echoes of Wisdom - 26.09.20241:40:38 Ace Attorney Investigations Collection - 06.09.20241:44:07 The Hundred Line: Last Defense Academy - 20251:48:41 Romancing SaGa 2: Revenge of the Seven - 24.10.20241:58:47 Elrentaros Wanderings - 16.08.2024Responding to Super Chats & Outro 2:01:32 Super Chat 1: "I knew that I was needed, how can I help?"2:01:59 Super Chat 2: "What some call over-leveled, I call being prepared."2:02:12 Super Chat 3: "Played Sea of Stars & unfortunately i don't share the same enthusiasm for it"2:08:18 Super Chat 4: "Fantasian physical is up for preorder on PlayAsia."2:10:15 Super Chat 5: "I finally beat Cold Steel 4!" 2:13:14 Outro

Esse episódio aborda um dos casos mais emblemáticos e misteriosos envolvendo transações internacionais ilícitas e fraude no Brasil: o escândalo do Banco Noroeste. Em 1995, Nelson Sakaguchi, executivo que comandava a diretoria internacional do banco, recebeu um fax com timbre do Ministério da Aviação da Nigéria. Era uma proposta de investimento num fundo destinado à construção de um aeroporto naquele país. A alta promessa de retorno atraiu Sakaguchi. Mas, aparentemente, os donos do banco não sabiam de nada e se surpreenderam quando uma auditoria interna revelou, em 1997, que Sakaguchi havia desviado US$ 240 milhões da instituição. E não havia aeroporto algum....

Seamus returns to derail us with butter talk! We discuss Black Clover, VERSION, Rokyo Bakuto-den Soga, and more! Then, we explore Masaaki Yuasa's revisionist rock opera, Inu-Oh for a new episode of Manga in Motion!!! We're doing a manga giveaway for our upcoming 500th episode! You can win a bundel of Panorama of Hell, Invisible Parade, From This Flame, and a Yuichi Yokoyama manga! To enter, write a review for Manga Machinations, then email us (mangamachinations@gmail.com) with the subject title "500 giveaway" and tell us where the review is! Deadline is May 17, 2024. Send us emails! mangamachinations@gmail.com  Follow us on Twitter! @mangamacpodcast Check out our website! https://mangamachinations.com Check out our YouTube channel! https://www.youtube.com/mangamactv Check out our new commentary channel! https://www.youtube.com/@MangaMacWatches Timestamps: Intro - 00:00:00 Listener Email - 00:09:03 Black Clover - 00:13:29 Delicious in Dungeon - 00:16:27 VERSION - 00:21:25 Rokyo Bakuto-den Soga - 00:29:45 Next Episode Preview - 00:33:58 Inu-Oh - 00:34:48 Outro - 01:29:28 Songs Credits: “Galaxy Groove” by Yarin Primak “Slappy” by Ido Maimon “Whipped Cream” by Steven Beddall “Psychedelic Funkadelic” by Evert Z

No one ever said the future would be easy. But I think we all saw the glimmer of a dream, somewhere in the sky that night. The tiniest spark of hope that we can change our fate. Who could say? That moment has come and gone.This week, Rick is joined by Chris (Retro Hangover Podcast) and Jon to focus on one of the black sheep of the Final Fantasy series, Final Fantasy XIII. The game certainly has a reputation - but is it earned? In the episode, we go over the presentation, the fantastic score (NOT by Uematsu!), the controversial datalog, and the troubled development. Is XIII worth a reexamination? You'll have to tune in to find out - do it up!Post mortem on FF XIII in GameDev magazineMore Retro Hangover PodcastClick on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Thanks for giving me time to think. To keep doing what you set your heart on...It's a very hard thing to do...What to do when I felt lonely...That was the only thing you couldn't teach me. But we need to figure out the answer for ourselves... I'm so happy I met everyone...But I guess we all have to say goodbye someday. Everyone... Thank you. Farewell. My memories will be part of the sky...The emotional conclusion to our Final Fantasy IX series is here. Rick and Eric begin by wrapping up some notable side quests throughout the game before tackling the rest of the narrative. The true nature of Zidane and Kuja's origins, the breakdown of our leader, the theories of the collective unconscious and the eternal return, and even the meaning of life...we talk about it all in this episode. Thank you, all, so much for being a part of this journey. I am so proud of what we have created.Check out Eric's podcast, The Unlockables, here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Viajamos de vuelta a Final Fantasy VII con los libros 500 años después y Cómo se hizo Final Fantasy VII X Remake. Analizamos las ideas de Sakaguchi, los textos de Nojima, las aspiraciones de Kitase y los diseños de Nomura en este podcast libre de spoilers sobre uno de los JRPG más mágicos de todos los tiempos. - Estudia online en ⁠ @UNIR ⁠ un máster o un grado en videojuegos, diseño gráfico digital, UX o multimedia. Pide más información sin compromiso: https://estudiar.unir.net/es/es-gen-area-ing-formacion-diseno-director-ejecutivo/ - Másters y Grados 100% oficiales; dan acceso a programas de doctorado y a trabajar como profesor univeristario - Formación 100% online; estudia sin cambiar tus rutinas - Pensados para gente que trabaja y quiere convertirse en diseñador de lo que le apasiona - Compra los libros que se mencionan en el podcast: 500 años después: Final Fantasy VII a través de sus creadores: https://amzn.to/3SIZ6Zf Cómo se hizo Final Fantasy VII X Remake: https://amzn.to/3UPJINq -

Save your valediction, Steiner. We will live to see another day.The saga continues, as once again Rick and Eric return to go through the entirety of Final Fantasy IX. This episode picks up after what we learned in Black Mage Village and sees us continue until we return there later - meeting a new Chocobo friend! This episode has us go through the beginning and majority of disc 3. Traditionally, this is seen as the part where the narrative tends to "drag" - but is that a fair assessment? Join us to find out. Do it up!(Thank you, thank you, THANK YOU for 100 episodes!) Check out Eric's podcast, The Unlockables, here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

"You're very kind to use our words. But you already know what it means to live...and to die. You're asking about our friends who have 'died,' not 'stopped.'" Note: This series has been extended to 5 parts rather than 4.Our coverage of Final Fantasy IX continues! Rick is joined once again by Eric (The Unlockables Podcast) as they continue through the world of Gaia. This episode covers the story from the beginning of disc 2 until arriving at Madain Sari. This episode is about growth: Garnet learns that she must foster her own independance; Steiner and Beatrix begin to see the true colors of the crown; and Vivi learns of his origins in one of the game's most famous sequences. It gets heavy - we hope you enjoy!Check out Eric's podcast, The Unlockables, here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

You Taught Me That Life Doesn't Last Forever. That's Why We Have To Help Each Other And Live Life To The Fullest.This is the beginning of a miniseries on Final Fantasy IX, one of the most important games in my life. This is the first time the show is revisiting a game that has been covered previously. In this personal essay, I explain why I made this choice, give some background history on the game, and speak about why this game means so much for me. This is part 1 of 5. We hope you enjoy this series - it has been deeply moving and rewarding to put together. Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

We'll never forget you. We'll remember you every time we stand at your grave. And we won't let the fear of death, which each of us knows, stop us from living our lives. Because my friends will remember me when I'm here.This is part 2 of 5 for our Final Fantasy IX analysis series. I am joined by Eric, from the Unlockables Podcast, who shares a deep love for this game. In this episode, we play from the beginning of the game up until the very end of disc 1. We meet the bulk of our cast, learn some disturbing truths about political powers, and much, much more. Check out Eric's podcast, The Unlockables, here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Satomi Yamamoto Sakaguchi, director-marketing for The Okura Tokyo, talks with James Shillinglaw of Insider Travel Report about why her more than 500-room property is the perfect choice for your Tokyo-bound luxury clients. Sakaguchi describes the accommodations, the multiple dining options and other amenities that make her property a city unto itself. For more information, visit https://theokuratokyo.jp/en. If interested, the original video of this podcast can be found on the Insider Travel Report Youtube channel or by searching for the podcast's title on Youtube.

"And when this too-long life of mine draws to a close," Kaim thinks, "I'd like to be sent off with the sound of bells like this if possible." Because he knows that day will never come, Kaim walks on, never stopping, never looking back. His long journey is far from over.Our three-part series on Lost Odyssey comes to a close in this final installment. The threads of the plot come together in an exciting conclusion - but is it earned? What do Rick and guest host Thrak (The 3DO Experience) think about the ending as it relates to the thematic identity of the game itself? Tune in to find out - it's an exciting ride!Check out more from The 3DO Experience here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

It is the voice of the little girl from eighty years ago, ringing ever clear, sweet and innocent, declaring farewell to the man who will travel life forever...We return for Part 2 of our miniseries on the Xbox 360 exclusive JRPG, Lost Odyssey. This episode is entirely story, and sees us pick up where we left off last time; if you are playing along, this episode covers up to and through the large "freezing" event that occurs on disc 2. We meet the rest of our party, learn more about Gongora's intentions, and begin to see the implications of the ever-shifting political landscape. Enjoy!Check out more from The 3DO Experience here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Deep in the heart of someone seeking freedom is the fact of freedom denied...This week, Rick is joined by friend of the show Thrak (The 3DO Experience Podcast) to dive into Lost Odyssey, somewhat of a hidden gem of a JRPG exclusive to the Xbox 360. What does it mean to live - to truly live - when one cannot die? This question lives at the core of the story being told - by none other than Hironobu Sakaguchi - as players take control of immortal Kaim Argonar, seeking for the stolen truth of his past. In part 1, we go over development history, the score, overall thematic concepts, and a portion of the story; if you're playing along, we conclude today's episode after getting captured by General Kakanas. This was such a blast to put together - do it up!Check out more from The 3DO Experience here!Click on the following to find PPR on the web!PatreonJoin our DiscordTwitter Instagram Bluesky Thank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

The photographers eye sees things the rest of us might not.  Haruka Sakaguchi uses the camera to tell stories about cultural identity and intergenerational trauma. Sakaguchi is a Japanese documentary photographer based in New York City. She was born in Osaka, Japan and immigrated to the US with her parents when she was three months old. Sakaguchi's documentary work focuses on cultural identity and intergenerational trauma.  Her clients have included The New York Times, National Geographic, Time Magazine, ProPublica, The New Yorker, Smithsonian Magazine, BBC News, Bloomberg Businessweek, NPR, Newsweek and The Washington Post among other publications.See omnystudio.com/listener for privacy information.

More FFXVI news from the PlayStation State of Play and we discuss the possibility of a demo.Trivia question of the day: Why did they call the first game Final Fantasy? (Answer at the bottom of the episode summary). Episode SummaryIntroduction / TriviaOur week in Final FantasyFFXVI Playstation ShowcaseTrivia answer: It was Sakaguchi's final pitch before leaving game development. Recommended ResourcesSubscribe on YouTube! https://www.youtube.com/channel/UCJ_1SSB0ZdFqhNJWWAzc96QFollow us on Twitter! https://twitter.com/HighwindHeraldKupo Quest! http://twitch.tv/kupoquestSolois Link Tree - http://linktr.ee/soloistvWolfkinz Link Tree - https://wolfkinz.comJoin our Discord! https://discord.gg/CK8mCMJ

Kai & Porkchop of the Canadian thrash metal band Rising Sun join me during episode 077 for a good chat about the band, new music, their musical history, and Porkchop's journey from India to Canada.  Rising Sun released their latest single, Archons of Death, on October 7, 2022.  Keep your ears peeled for new music! Support the show

00:00 Début 15:53 A quoi on joue 37:33 State of Play de Sony de 23/02/2023 57:57 2 Millions pour HiFi Rush 58:47 Preview de Final Fantasy XVI 01:05:47 Extension Elden Ring : L'ombre de l'arbre Monde 01:08:14 Pokemon Direct 27/02/2023 01:16:09 Départ chez Ubisoft Montpellier / Beyond Good and Evil 2 devient le jeu au plus long développement 01:23:54 Square Enix Absorbe Luminous Production à la suite des résultats peu convaincants de Forspoken 01:30:17 Sakaguchi aimerait un portage de Fantasia et une suite

I'm a general, not some podcasting floozy!We're back once again for our continuing mini-series on Final Fantasy 6. This episode goes through some incredibly memorable moments from the game, including suplexing a train and (up to and finishing with) the game's famous opera scene. We also meet a pesky octopus. Joined once again by Chris from Retro Hangover, so you know we're going to have a great time! Thanks again to the listeners who voted to get this game on the show - we love doing content that YOU want to see!MORE RETRO HANGOVER: https://linktr.ee/retrohangover PATREON: www.patreon.com/pixelprojectradioDISCORD: https://discord.gg/Rfjx2ptWP5TWITTER: @pixelprojectpodINSTAGRAM: @pixelprojectradiopodcastThank you for listening! Want to reach out to PPR? Send your questions, comments, and recommendations to pixelprojectradio@gmail.com! And as ever, any ratings and/or reviews left on your platform of choice are greatly appreciated!

Almonds A Workout Superfood improved mitochondrial function, reduced fat mass, fasting insulin and triglycerides, and is elevated in the blood compartment after an acute bout of exercise in both male and female subjects (57). In general, the elevated post-exercise plasma levels of 12,13-DiHOME with almond intake support positive metabolic outcomes for adults engaging in unaccustomed eccentric exercise bouts. Other almond-related benefits for exercisers revealed in this study include reduced feelings of fatigue and tension, better leg-back strength during recovery, and decreased muscle damage during the first day of recovery. #oxylipin #almonds #musclerecovery Nieman, D. C., Omar, A. M., Kay, C. D., Kasote, D. M., Sakaguchi, C. A., Lkhagva, A., Weldemariam, M. M., & Zhang, Q. (2023). Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.1042719 Almonds, polyphenols, muscle, recovery, training, mood, endurance, stamina, octadecenoic acid , almond skin, POMS, exercise --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Almonds A Workout Superfood improved mitochondrial function, reduced fat mass, fasting insulin and triglycerides, and is elevated in the blood compartment after an acute bout of exercise in both male and female subjects (57). In general, the elevated post-exercise plasma levels of 12,13-DiHOME with almond intake support positive metabolic outcomes for adults engaging in unaccustomed eccentric exercise bouts. Other almond-related benefits for exercisers revealed in this study include reduced feelings of fatigue and tension, better leg-back strength during recovery, and decreased muscle damage during the first day of recovery. #oxylipin #almonds #musclerecovery Nieman, D. C., Omar, A. M., Kay, C. D., Kasote, D. M., Sakaguchi, C. A., Lkhagva, A., Weldemariam, M. M., & Zhang, Q. (2023). Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.1042719 Almonds, polyphenols, muscle, recovery, training, mood, endurance, stamina, octadecenoic acid , almond skin, POMS, exercise --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Fumi Saito & Justin Knipper talked about the long-spanning career of NJPW stalwart and former big boss, Mr. Seiji Sakaguchi. From his time as a judoka to his early trips to the US, and from his time inside and outside the ring with Antonio Inoki, Giant Baba, and others, Fumi & Justin cover the full career of the true lieutenant of New Japan. Join the Patreon for just $5.00 per month here: https://www.patreon.com/fightgamemedia Follow us on Twitter: https://twitter.com/fightgamemedia Subscribe to our YouTube Page: https://www.youtube.com/c/FightGameMedia Follow us on Instagram: https://www.instagram.com/fightgamemedia Learn more about your ad choices. Visit podcastchoices.com/adchoices

Remember that you can always get in touch with us on our Discord server, Facebook page, on Twitter, or with our Contact page.From mocap to Resident Evil, and from the passing of a family member to a financial loss of $105 million. This week we talk about the commercial failure (and reason why Square-Enix games where Playstation 2 exclusives for a long time) Final Fantasy: The Spirits Within.psst. we've actually done a bunch of these "goes to the movies" episodes. Check this page to see all of the released specials.Here's a sample of the full show notes - make sure to click through and check them out.Content WarningPlease listen responsibly.Show NotesIn this "Goes to the Movies" episode, we wanted to tackle a movie which isn't necessarily based on an actual game, per se - but keep a look out for Jay's interpretation, very soon - so we tackled Final Fantasy: The Spirits Within.As with our House of the Dead episode - do check that out, if you want to hear the boys talking smack about an Uwe Boll movie - we decided to change up the format of our "goes to the movies" episodes. Instead of working through the plot, we decided that it would be much more fun to focus on a handful of scenes from the movie. This serves the double purpose of: Simplifying our episodes, and getting to the gags quicker Not having to discuss the plot which this movie doesn't have Just before we started recording though, Chief uttered the following famous last words:I'm a pro at this now, I've done that many episodes that I could probably do this myself.- ChiefWith that said, we jumped to jump straight into a description of this movie...Basic Info on the MovieJay dropped some key facts on this movie before we could get to our discussion on it:This is a movie that was released in 2001... it is THE reason why a whole bunch of Square-Enix games that came out after that were PlayStation exclusives for a long time... it is known as the 4th biggest box-office bombs of all time... it cost (in 2022 dollars) $190 MILLION to make, and almost drove Square out of business... and only ever made $85 million back, which is less than half of it's budget.- JayInterestingly, the story that this movie was based on - the script was originally called Gaia - was written during the final few days of working on Final Fantasy VII, and was written by Hironobu Sakaguchi shortly after his mother passed away. It was then re-written by Al Reinert (co-writer of Apollo 13) & Jeff Vintar (writer of I, Robot), and was combined with three years of RnD in Hawaii to create the final movie.It's also important to remember that the fallout of this movie lead to the merger between Square and Enix almost being canned. Both companies were in pretty dire straits - even with the rousing success of both Final Fantasy VII and VIII - and Sony had to step in to buy a (reported) 20% stake in Square to keep the merger alive (as Enix wanted to pull out). And this is why a large number of Square-Enix games of the early 2000s were Playstation exclusives.Just think about that for a second: The Spirits Within was that expensive and that much of a flop that it undid all of the profits from both Final Fantasy VII and VIII.Initial ThoughtsEach of the boys agreed that the movie is beautiful to look at, especially for it's time.I don't think I'd willingly go back and watch it again, though.- ChiefBefore we got into the movie proper, Jay asked:With 0 being the worst and 10 being the best, how would you rate this film as a film? Imagine that it's an IGN score though: it doesn't mean anything- Jay Chief: 5 Squidge: Numberwang (or a 7) Jay: unrated Chief had this to say about his score:What I mean is it's a middling film. The plot is serviceable, if a little uninteresting and uninspired. It makes sense, and the animation is good... but one thing I will say about the sound, though. You know when they're firing the weapons? It always feels under-powered.- ChiefSquidge had this to say about his score:I've seen some good CGI movies, and I've seen some $h!t. And so many years later, it holds up... some of the best parts of the movie are Steve Buschemi... the pacing is way too fast, then way too slow.- SquidgeAnd the boys all agree that the movie would have made a great limited series or a game. In fact, they all agree that it plays out very much like a video game.You could probably make [this into] a tactical shooter, survival horror game.- JayHad Netflix been a streaming service back in the tail end of the 90s - rather than just a DVD rental service - they would have bitten Sakaguchi's hand off to make it.It's just done too quick, isn't it? There's good stuff in there, but it's so rushed over that by the time you get to it, you think "ugh, well I've seen that now."- ChiefFull Show NotesMake sure to check out the full show notes for more discussion on the points we raise, some extra meta-analysis, some out-of-context screen grabs from the movie, and some links to related things.Are you a fan of the Final Fantasy games? Have you seen this movie before? If so, what did you think to it? Would you fling it into a tree? If not, are you likely to watch it now?psst. we've actually done a bunch of these "goes to the movies" episodes. Check this page to see all of the released specials.What other movies would you like us to cover? Let us know on Discord, Twitter, Facebook, or try our brand new contact page.LinksHere are some links to some of the things we discussed in this episode: Join our Discord server and be part of future episodes Us on Twitter Our Facebook page Support us on Ko-Fi Final Fantasy: The Spirits Within And have you left us a rating or review? We really like to hear back from listeners about our show, so check out https://wafflingtaylors.rocks/our-podcast/ for links to services where you can leave us some wonderful feedback.The Waffling Taylors is a proud member of Jay and Jay Media. If you like this episode, please consider supporting our Podcasting Network. One $3 donation provides a week of hosting for all of our shows. You can support this show, and the others like it, at https://ko-fi.com/jayandjaymedia ★ Support this podcast ★

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.20.512984v1?rss=1 Authors: Leiwe, M. N., Fujimoto, S., Baba, T., Moriyasu, D., Sakaguchi, R., Saha, B., Inagaki, S., Imai, T. Abstract: Fluorescence imaging is widely used for the mesoscopic mapping of neuronal connectivity. However, neurite reconstruction is challenging, especially when neurons are densely labelled. Here we report a strategy for the fully automated reconstruction of densely labelled neuronal circuits. Firstly, we established stochastic super-multicolour labelling with up to seven different fluorescent proteins using the Tetbow method. With this method, each neuron was labelled with a unique combination of fluorescent proteins, which were then imaged and separated by linear unmixing. We also established an automated neurite reconstruction pipeline based on the quantitative analysis of multiple dyes (QDyeFinder). To classify colour combinations, we used a newly developed unsupervised clustering algorithm, dCrawler, in which data points in multi-dimensional space were clustered based on a given threshold distance. Our new strategy allows for the reconstruction of neurites for up to hundreds of neurons at a millimetre scale without manual tracing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Diving into the latest Yoshi-P Q&A from the 14 Hour Broadcast and Sakaguchi Interviews FFXIV Yoshi-P Interviews | Sakaguchi Interview | FFXIV 2023 Outlook

durée : 00:01:48 - BD bande dessinée - par : Jean-Christophe OGIER - Revival réédite "Fleurs de pierre", de Hisashi Sakaguchi, une impressionnante fresque historique qui prend place en Yougoslavie dans les années 40.

Esta noche hablamos de dos joyas de la literatura de horror nipona: En el bosque, bajo los cerezos en flor y Audition.

On our sixth episode, Erin welcomes Isa Sakaguchi, Graduate Student and Graduate Teaching Assistant at West Virginia University, to talk about her WVU experience. Key topics for this episode include: 1) why Isa chose WVU for graduate school, 2) talent VS passion in your career, 3) the benefits of being a Graduate Assistant (professional development, finances, etc.), and 4) the importance of getting involved on campus as a graduate student. If you are interested in graduate education at West Virginia University, please visit our website at www.graduateadmissions.wvu.edu. Don't forget to subscribe to our blog or download one of our online resource guides for more information about the GRE, specific career industries, tips on how to submit your strongest graduate application and more!If you enjoyed or found value in this podcast, please leave a review on your favorite listening platform or follow us on the following social media networks:FacebookTwitterInstagram

0:00-33:04 The Weeks and our superpower conversation 33:40-41:53 Mythforce looks like Skyrim + Flash Gordon 42:21-51:00- Sony & Lego have invested BILLIONS into the Epic Games Store but why??? 51:29-54:00 Elyuden Chronicles is a new RPG out here 55:28-1:11:55Is Zelda too big for the Switch... probably not itl be fine lol 1:12:00-1:29:32 Sakaguchi been playing some games and oddly enough Kingdom Hearts 4 got aanounced 1:29:32- Vicarious has Merged with Blizzard so goodbye Tony Hawk pro skater remake and Hello WOW remake! Game of the Week Baman Arkham Knight --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/nerd-plate/support

This week, we're talking about the Dragon Quest game that isn't Dragon Quest at all - Blue Dragon, the really fun JRPG from Final Fantasy's Hironobu Sakaguchi and Akira Toriyama. It's not just the art that looks the same, though, there are a lot of mechanics and monsters that feel super Dragon Quest-y too. Plus, a little bit about the Dai manga (which we'll get to next week) and Elder Scrolls: Oblivion. You can support this podcast by visiting Patreon.com/DragonQuestFM --- Send in a voice message: https://anchor.fm/dragonquest/message Support this podcast: https://anchor.fm/dragonquest/support

In this episode of the Epigenetics Podcast, we caught up with Manel Esteller, Director of the Josep Carreras Leukemia Research Institute to talk about his work on Epigenetics and Epitranscriptomics in Cancer. The focus of Manel Esteller's research career and the focus of his current team is to characterize the epigenome and epitranscriptome of cancer cells in comparison to healthy cells, and their interplay. Ultimately, their goal is to use this knowledge to develop new therapies for cancer. Key achievements from the Esteller lab began with the discovery of the first miRNA that undergoes specific cancer-methylation associated silencing. The team further identified many more miRNAs that also play a role in cancer. Next to miRNAs, Manel Esteller studied the influence of lncRNAs, enhancers and DNA methylation on cancer development and progression, insights that may be used to develop cancer biomarkers and potential treatments.     References Guil, S., Soler, M., Portela, A., Carrère, J., Fonalleras, E., Gómez, A., Villanueva, A., & Esteller, M. (2012). Intronic RNAs mediate EZH2 regulation of epigenetic targets. Nature Structural & Molecular Biology, 19(7), 664–670. https://doi.org/10.1038/nsmb.2315 Vizoso, M., Ferreira, H. J., Lopez-Serra, P., Carmona, F. J., Martínez-Cardús, A., Girotti, M. R., Villanueva, A., Guil, S., Moutinho, C., Liz, J., Portela, A., Heyn, H., Moran, S., Vidal, A., Martinez-Iniesta, M., Manzano, J. L., Fernandez-Figueras, M. T., Elez, E., Muñoz-Couselo, E., … Esteller, M. (2015). Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR. Nature Medicine, 21(7), 741–750. https://doi.org/10.1038/nm.3863 Agrelo, R., Cheng, W.-H., Setien, F., Ropero, S., Espada, J., Fraga, M. F., Herranz, M., Paz, M. F., Sanchez-Cespedes, M., Artiga, M. J., Guerrero, D., Castells, A., von Kobbe, C., Bohr, V. A., & Esteller, M. (2006). Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proceedings of the National Academy of Sciences of the United States of America, 103(23), 8822–8827. https://doi.org/10.1073/pnas.0600645103 Lopez-Serra, P., Marcilla, M., Villanueva, A., Ramos-Fernandez, A., Palau, A., Leal, L., Wahi, J. E., Setien-Baranda, F., Szczesna, K., Moutinho, C., Martinez-Cardus, A., Heyn, H., Sandoval, J., Puertas, S., Vidal, A., Sanjuan, X., Martinez-Balibrea, E., Viñals, F., Perales, J. C., … Esteller, M. (2014). A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nature Communications, 5, 3608. https://doi.org/10.1038/ncomms4608 Rosselló-Tortella, M., Llinàs-Arias, P., Sakaguchi, Y., Miyauchi, K., Davalos, V., Setien, F., Calleja-Cervantes, M. E., Piñeyro, D., Martínez-Gómez, J., Guil, S., Joshi, R., Villanueva, A., Suzuki, T., & Esteller, M. (2020). Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer. Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20785–20793. https://doi.org/10.1073/pnas.2003358117 Castro de Moura, M., Davalos, V., Planas-Serra, L., Alvarez-Errico, D., Arribas, C., Ruiz, M., Aguilera-Albesa, S., Troya, J., Valencia-Ramos, J., Vélez-Santamaria, V., Rodríguez-Palmero, A., Villar-Garcia, J., Horcajada, J. P., Albu, S., Casasnovas, C., Rull, A., Reverte, L., Dietl, B., Dalmau, D., … Esteller, M. (2021). Epigenome-wide association study of COVID-19 severity with respiratory failure. EBioMedicine, 66, 103339. https://doi.org/10.1016/j.ebiom.2021.103339   Related Episodes CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) Cancer and Epigenetics (David Jones)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

- Un ataque a Steam en China bloqueó durante la Navidad la aplicación varias horas. Debido a este ataque a través de las DNS de la tienda de Valve, los usuarios, además de no poder a la tienda, creyeron que se trataba de una nueva prohibición del gobierno chino. - Josef Fares, creador de It Takes Two, prefiere «un tiro en la rodilla a los NFT en videojuegos». Así de tajante respondía el director en una entrevista para The Washington Post, mostrándose muy crítico con cómo las compañías están aceptando incluir estos elementos en sus títulos. - Everwild podría haber reiniciado su desarrollo, según Jeff Grubb. El insider especializado en Xbox comentaba en su podcast que el título habría vuelto a empezar de cero debido a que «era un auténtico desastre». Habla también de que se están marchando empleados y que Rare no sabe bien qué rumbo darle a este proyecto. - Yasumi Matsuno, quien fuera director de Vagrant Story y Final Fantasy Tactics, está trabajando en un nuevo proyecto. Esta información viene ni más ni menos que del mismísimo Sakaguchi, creador de Final Fantasy, así que podemos darla como bastante fiable. - Los juegos del PS Plus de enero de 2022 serán los siguientes: Persona 5 Strikers, Dirt 5 y Deep Rock Galactic. Puedes encontrarme en Twitter como @nachocerrato.

A brief history of the beginning of KCCL, and how things have changed over the years by Rachel Felbeck, Sakaguchi, Felbech & Reese, PLLC; Loretta Story,  Story Law; and Courtney Story, Story Law

We finally finish the first half of the enormous interview Famitsu did with Yoshi-P about the lore of FFXIV and the future of the game. We also look closer at some interview bits translated by Sakaguchi, as well as some teasing by Yoshi-P about 6.1 and beyond from another upcoming Famitsu interview! And of course: MogMail! Akh Morning Interview Translation: https://www.akhmorning.com/news/famitsu-yoshida-interview-shadowbringers-lore-part-1/#ffxiv-producer-and-director-naoki-yoshida-reveals-the-naked-truth-and-secret-stories-behind-shadowbringers-part-12 ► Patreon: https://www.patreon.com/SpeakersXIV ► Become a Speakers YT Member: https://www.youtube.com/channel/UC2BQVHKP5x3Cs62MB0DF5EQ/join ► Merchandise: https://teespring.com/stores/speakersxiv ► Follow us on Twitter: https://twitter.com/SpeakersXIV ► Catch us LIVE on Twitch: http://www.twitch.tv/speakersofhydaelyn ► Speakers Discord: https://discord.gg/ATBUccS

Llega un nuevo podcast donde debatimos la actualidad de PlayStation. -NOTICIAS DESTACADAS (PlayStation): Problemas stock PS5 pues va para largo la cosa ¿Un God of War en primera persona? WTF??? NOTICIAS DESTACADAS (Third Party) Babylon´s Fall vuelve presentando sus mejoras Kingdom Hearts anuncia su evento para el 20º aniversario -RUMORES/FILTRACIONES Bloodborne 2, otra vez, si, no es broma PlayStation y su gran remake en diciembre. Hacemos nuestras apuestas -TERMÓMETRO La charlita de Sakaguchi y Yoshida, buen rollo//Ghost Recon se convierte en un fornite pocho Los juegos del PS Now de este mes, pues ni tan mal//La beta del Battlefield 2042 pues como que muy bien no está Las lolis salvan la TGS 2021 (Atelier Sophie 2)//GTA Trilogy, no te sigo Rockstar -DEBATE/SALSEO Las traducciones en los videojuegos ¿son rentables? -LANZAMIENTOS SEMANA

Episode 59. Finding Your Authentic Voice with Tomoko Sakaguchi Harmond - Our guest today is Tomoko Sakaguchi. Tomoko is a professional singer and a vocal coach and we talk about finding your authentic voice. Tomoko has immigrated from Japan to live in the US and has developed this very interesting and unique methodology called the rebelting method. She helps artists discover their authentic voice through singing and she also answers a question I've had for a long time; can anyone learn to sing? Tomoko explains to us how you too can learn to bring that authentic voice in yourself through song. Learn more and get show notes and transcripts by visiting www.confidencefromwithin.caListen now to learn… Tomoko's story and the sequence of events that led her in the path to becoming a professional singer and founding the Rebelting method!What is the authentic voice that Tomoko helps her students and clients find?Tomoko's answer to the question; can anyone learn to sing beautifully?Resources to get you started:STOP SELF-SABOTAGING YOUR WEIGHT LOSS = naturallyjoyous.ca/freetrainingWORK WITH ME - BOOK YOUR COMPLIMENTARY MEET & GREET CALL = http://naturallyjoyous.ca/callAbout Guest NameTomoko Sakaguchi Harmond, Chico, is a professional singer and vocal coach, as well as a mind coach for artists. She's the founder of the revolutionary singing method, "REBELTING METHOD". Her mission is to help people find the beauty in their authentic voice.Here is where you can find her:Website: rebelting.comInstagram: @rebeltingmethodIf you enjoyed today's episode, please:Post a screenshot & key takeaway on your Instagram story and tag me @naturally.joyous so I can repost you Leave us a positive review on Apple Podcasts, HERE is howSubscribe to the Confidence From Within Podcast, we release new episodes every Friday! See acast.com/privacy for privacy and opt-out information.

This week, Chris finally gets his revenge as the wheel throws up not 1, not 4 but 3 of his fetid picks!Join Rob and Garth as they expose themselves to Chris's increasingly smarky wrestling fandom as he welcomes into his world of DDT and Bloodsport!...oh and a pretty good G1 Climax match from back in 2014!Don't forget to check out the live video on our Facebook Page and on the website!All this and more on this week's episode of the PodMania Podcast!Subscribe to the Podcast: https://linktr.ee/PodManiaPodcastsFollow Rob here; https://www.twitter.com/REALRobGoodwinFollow Garth here; https://www.twitter.com/thegarthbergFollow Chris here; https://www.twitter.com/chrislovespuroBuy our Merch: https://teespring.com/en-GB/stores/podmania-podcasting-networkFollow PODMANIA here!Website: https://www.podmania.co.ukTwitter: https://www.twitter.com/podmaniaFacebook: https://www.facebook.com/groups/podmaniapodcasts

Watch the video here! https://youtu.be/N-SN8_Cotfc When I started FFtv last year, the goal was to spotlight and interview Developers, Actors, and Community Members. We've had the great privilege of speaking with so many incredible guests but we hadn't had a chance to speak with a developer. I never would have imagined that the first dev we'd speak to would be The Father of Final Fantasy himself.. Yesterday, April 30th we spoke with Sakaguchi-san about his latest game Fantasian. It was surreal. No matter what happens from here on out, FFTV has given us one of the most unforgettable experiences. Thank you to Sakaguchi-san, Mistwalker, and all of you Final Fans for your continuous support. Please enjoy!

This episode sees Adam and Kiaran taking a stroll down memory lane and playing Part 1 of the Final Fantasy VII Remake. Tune in to find out what we thought of our experience, the additional content, and the ending. Story spoilers discussed at the end and what we think it means for Part 2 in the series.

Danny, Beast Mike and Greg have a new intro, Facebook, YouTube page but the same classic wrestling to watch and the fiery takes. This week's episode featured talk on:Bob Backlund vs Sgt Slaughter (WWF 3/21/1981 Cage)Giant Baba vs Billy Robinson (AJPW 7/24/76)Inoki, Sakaguchi, Fujiwara, Hoshino & Mutoh vs Fujinami, Choshu, Maeda, Kengo Kimura & Super Strong Machine 3/21/1987 NJPWKansai, Masami, Fukuoka & Yagi vs Ozaki, Cutie Suzuki, Okutsu & Toyama, 1-count match, JWP 3/21/95.Great Muta vs Tatsumi Fujinami (9.23.91 NJPW) (Forgive me this is the version without the entrances as that version we watched was taken down becuse NJPW world now has it)Follow Great Match Generator on Facebook Subscribe on Youtube Follow Danny, Mike. and Greg on TwitterDiscuss the Greatest Match Ever over hereVisit Social Suplex over hereSupport this podcast at — https://redcircle.com/social-suplex-podcast-network/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

It all started with Hironobu Sakaguchi, and we discuss what possibly is his last game that can be played on a console.