Podcasts about spindles

Another Snow White adaptation from the 2012 Snow White renaissance–it's Mirror Mirror! We're joined by Cassie from Of Slippers and Spindles to talk about this bonkers, rococo rendition of the Snow White tale. Cullen invents the concept of ingénue-ity, Hannah criticizes Snow White's conspicuous fashion choices, and Cassie begs for character growth from the Prince.   Check out Cassie's fairy tale adaptation podcast, Of Slippers and Spindles wherever you get your podcasts! Follow them on Instagram, Facebook and Discord.    Research for this episode: The Fairest of Them All by Maria Tatar    ====================================   Watch Us on YouTube!   Follow Our Adventures on Social Media:   @notmyfantasypod Instagram TikTok   Research & Writing by Cullen Callaghan.  This episode was edited by Hannah Sylvester.   Cover Art by William Callaghan Intro Music: "The Quest" by Scott Little.

In this episode, Sasha shares her system for keeping track of her ever-growing spindle collection. Mentioned in this episode: Podcast Freebie: Click here to download You can find the script for this episode HERE. You can comment on and discuss this episode here in The Flock, Sheepspot's free online community for inquisitive spinners. Here's the link to the Podcast search page and playlists. 

The NoSleep Podcast presents its 2024 Halloween Celebration! "Adam's Halloween" written by Lorri Stackhouse (Story starts around 00:02:50) TRIGGER WARNING! Produced by: Phil Michalski Cast: Narrator - Elie Hirschman "The Hollow Ween" written by K.G. Lewis (Story starts around 00:14:45) TRIGGER WARNING! Produced by: Claudius Moore Cast: Jacob - Jeff Clement, Leonard - Matthew Bradford, Mom - Ashley McAnelly, Mr. Adamson - Peter Lewis "Strangling Angels" written by Riel Rosehill (Story starts around 00:31:00) Produced by: Phil Michalski Cast: Alec - Jake Benson, Leslie - James Cleveland, Haley - Ash Millman "Accidents Happen" written by L.P. Hernandez (Story starts around 00:40:55) TRIGGER WARNING! Produced by: Jesse Cornett Cast: Narrator - Atticus Jackson, Teen Boy - Matthew Bradford, Man - Jesse Cornett, Wayne - Mike DelGaudio "Mr. Spindles" written by Beth Carpenter (Story starts around 01:12:35) TRIGGER WARNING! Produced by: Jeff Clement Cast: Narrator - David Ault, Ms. Grimshaw - Penny Scott-Andrews "The Neighbors" written by Charlie Davenport (Story starts around 01:36:10) TRIGGER WARNING! Produced by: Phil Michalski Cast: Andy - Kyle Akers, Stacey - Nichole Goodnight, Kevin - Allonté Barakat, Will - Dan Zappulla, Officer Knotts - Peter Lewis, Mr. O'Herlihy - Mike DelGaudio, Homeowner - Jesse Cornett, Devil Girl - Sarah Thomas, Neighbors - Jeff Clement, Matthew Bradford, Ashley McAnelly, Ash Millman, Atticus Jackson This episode is sponsored by: Betterhelp - This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/nosleep and get on your way to being your best self. Click here to learn more about The NoSleep Podcast team Click here to learn more about Lorri Stackhouse Click here to learn more about Riel Rosehill Click here to learn more about L.P. Hernandez Executive Producer & Host: David Cummings Musical score composed by: Brandon Boone "Halloween 2024" illustration courtesy of Kelly Turnbull Audio program ©2024 - Creative Reason Media Inc. - All Rights Reserved - No reproduction or use of this content is permitted without the express written consent of Creative Reason Media Inc. The copyrights for each story are held by the respective authors.

Send us a textFor the bonus episode this month Michael & Barbara review the final book in the Realm Breaker Trilogy, Fate Breaker by Victoria Aveyard! Like all of our reviews, the first part is spoiler free.Here's a little about Fate Breaker:A dark fate descends. A shattered alliance must rise.The Companions are torn apart and the realm hangs in the balance, at the edge of ruin. Taristan and Queen Erida rise triumphant from the battlefield, while Corayne barely escapes with her life; her Companions left behind to uncertain fates.But not all hope was lost: Corayne managed to steal Taristan's Spindleblade. Without it, Taristan can't rip open any more Spindles. Without it, he can't end the world.Now, from every corner of the realm, the Companions race to reunite while they rally old allies and seek unexpected new ones, in one final push against darkness.But Taristan and Erida are all but invincible. With their cruel god, What Waits, on their side, they will sacrifice anything and anyone to his hunger.Everything has come to this. In the final clash between good and evil, a ragged alliance makes its bravest stand against a ruthless enemy . . . and the demon god who would consume the realm entire.We hope you enjoy the episode!Do you have a book you'd like us to review on this show? Send us an email at badassliteraturesociety@gmail.comIf you don't already, follow us on Instagram and FacebookArt by Justin Miller DesignCheck us out here!

It's a jam-packed episode of Lean Built as Jay and Andrew kick things off with a head-to-head: spindles versus pallet pools. Which one packs the bigger profit punch? From there, they steer back into the world of IMTS, and especially how bringing your team and employing them strategically can yield big results. But that's not all. They tackle machine aesthetics—does beauty equal beast in manufacturing? They also dissect the double-edged sword of automation, and the art of slashing unnecessary steps to streamline your operations like a pro. All that and plenty more. Thanks as always for joining us on our Lean Built journey.

Halftime Heroes, hosted by Adam 'Shortpass' Kelly, Luke 'Spook' Harris, Neil 'Commish' Craig and Peter 'Sus' Susovich. Join the Heroes as they bring you through all the news and the big topics currently in the MPFNL. A light hearted, entertaining Podcast that we never take too seriously. Joining the Heroes this week for the review: Special Guest – Jarrod Grant – Playing Coach Frankston FNC. You might know him as 'Spindleshanks' or 'Microphone Head' but the Heroes know him as one of the nicest blokes in the MPFNL. Went No. 5 in the 2007/2008 AFL Draft, played 81 games with Westren Bulldogs and 14 games with Goldcoast Suns. Spindles shares his thoughts on the Div 1 comp at the mid way point. The 2024 MPFNL Mid Season Review. Check us out online Halftime Heroes Website Halftime Heroes Facebook PageSee omnystudio.com/listener for privacy information.

Never ONCE cared about the color of the spindles.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Become a supporter of this podcast: https://www.spreaker.com/podcast/arroe-collins-unplugged-totally-uncut--994165/support.In a final clash between kingdoms and gods, all must rise to fight - or be destroyed.Everything has come to this. Prepare for a larger-than-life, unforgettable finale to the instant New York Times bestselling Realm Breaker series, where a shattered alliance must rise from the ashes to make their final stand against a ruthless enemy…and the demon god who looks to shroud the entire world in darkness.The Companions are scattered and hopeless, torn from each other. After Corayne barely escapes with her life, she must forge on alone, leaving her blade broken and her allies behind her. Her only consolation: Corayne now has Taristan's sword, the only Spindleblade left in existence. Without it, he can't rip open any more Spindles. Without it, he can't end the world. But Taristan and Queen Erida will not be defeated so easily. Both will burn the world to bring down Corayne - and bring forth their demon god, What Waits, ready to claim the realm of Allward for his own.Victoria Aveyard was born and raised in East Longmeadow, Massachusetts, a small town known only for the worst traffic rotary in the continental United States. She moved to Los Angeles to earn a BFA in screenwriting at the University of Southern California. She currently splits her time between the East and West coasts. As an author and screenwriter, she uses her career as an excuse to read too many books and watch too many movies. She is also the author of the New York Times bestselling Red Queen series.

In a final clash between kingdoms and gods, all must rise to fight - or be destroyed.Everything has come to this. Prepare for a larger-than-life, unforgettable finale to the instant New York Times bestselling Realm Breaker series, where a shattered alliance must rise from the ashes to make their final stand against a ruthless enemy…and the demon god who looks to shroud the entire world in darkness.The Companions are scattered and hopeless, torn from each other. After Corayne barely escapes with her life, she must forge on alone, leaving her blade broken and her allies behind her. Her only consolation: Corayne now has Taristan's sword, the only Spindleblade left in existence. Without it, he can't rip open any more Spindles. Without it, he can't end the world. But Taristan and Queen Erida will not be defeated so easily. Both will burn the world to bring down Corayne - and bring forth their demon god, What Waits, ready to claim the realm of Allward for his own.Victoria Aveyard was born and raised in East Longmeadow, Massachusetts, a small town known only for the worst traffic rotary in the continental United States. She moved to Los Angeles to earn a BFA in screenwriting at the University of Southern California. She currently splits her time between the East and West coasts. As an author and screenwriter, she uses her career as an excuse to read too many books and watch too many movies. She is also the author of the New York Times bestselling Red Queen series.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.28.546981v1?rss=1 Authors: Blanco-Duque, C., Bond, S. A., Krone, L. B., Dufour, J.-P., Gillen, E. C. P., Kahn, M. C., Purple, R. J., Bannerman, D. M., Mann, E. O., Achermann, P., Olbrich, E., Vyazovskiy, V. V. Abstract: Sleep spindles are traditionally defined as 10-15Hz thalamo-cortical oscillations typical of NREM sleep. While substantial heterogeneity in the appearance or spatio-temporal dynamics of spindle events is well recognised, the physiological relevance of the underlying fundamental property -the oscillatory strength - has not been studied. Here we introduce a novel metric called oscillatory Quality (o-Quality), which is derived by fitting an auto-regressive model to short segments of electrophysiological signals, recorded from the cortex in mice, to identify and calculate the damping of spindle oscillations. We find that the o-Quality of spindles varies markedly across cortical layers and regions and reflects the level of synchrony within and between cortical networks. Furthermore, the o-Quality of spindles varies as a function of sleep-wake history, determines the strength of coupling between spindles and slow waves, and influences the responsiveness to sensory stimulation during sleep. Thus, the o-Quality emerges as a metric that, for the first time, directly links the spatio-temporal dynamics of sleep spindles with their functional role. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.22.537937v1?rss=1 Authors: McLaren, J. R., Luo, Y., Kwon, H., Shi, W., Kramer, M. A., Chu, C. J. Abstract: Objective: Epileptic encephalopathy with spike wave activation in sleep (EE-SWAS) is a challenging neurodevelopmental disease characterized by abundant epileptiform spikes during non-rapid eye movement (NREM) sleep accompanied by cognitive dysfunction. The mechanism of cognitive dysfunction is unknown, but treatment with high-dose diazepam may improve symptoms. Spike rate does not predict treatment response, but spikes may disrupt sleep spindles. We hypothesized that in patients with EE-SWAS: 1) spikes and spindles would be anticorrelated, 2) high-dose diazepam would increase spindles and decrease spikes, and 3) spindle response would be greater in those with cognitive improvement. Methods: Consecutive EE-SWAS patients treated with high-dose diazepam that met criteria were included. Using a validated automated spindle detector, spindle rate, duration, and percentage were computed in pre- and post-treatment NREM sleep. Spikes were quantified using a validated automated spike detector. Cognitive response was determined from chart review. Results: Spindle rate was anticorrelated with spike rate in the channel with the maximal spike rate (p=0.002) and averaged across all channels (p=0.0005). Spindle rate, duration, and percentage each increased, and spike rate decreased, after high-dose diazepam treatment (p less than or equal to 2e-5, all tests). Spindle rate, duration, and percentage (p less than or equal to 0.004, all tests) were increased in patients with cognitive improvement after treatment, but not those without. Changes in spike rate did not distinguish between groups. Interpretation: These findings confirm thalamocortical disruption in EE-SWAS, identify a mechanism through which benzodiazepines may support cognitive recovery, and introduce sleep spindles as a promising mechanistic biomarker to detect treatment response in severe epileptic encephalopathies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode, we review the high-yield topic of Muscle Spindles/Golgi Tendon ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Neurology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.31.534952v1?rss=1 Authors: Ghibaudo, V., Juventin, M., Buonviso, N., Peter-Derex, L. Abstract: Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In the rodent, this respiratory drive strongly varies according to vigilance states. Particularly, during sleep, respiration promotes the coupling between hippocampal sharp-wave ripples and cortical DOWN/UP state transitions. However, no study has examined whether sleep spindles could be respiration-modulated in humans. In this work, we aimed to investigate the influence of breathing on brain oscillations during non-rapid-eye-movement stage 2 sleep (N2) in humans by examining the coupling between sleep spindles and respiration cycle. Full night polysomnography of twenty healthy participants were analysed. Spindles and slow waves were detected during N2 sleep stage. Spindle-related sigma power as well as spindle and slow waves events were analysed according to the respiratory phase. We found a significant coupling between slow and fast spindles with respiration cycle, with enhanced sigma activity and probability of occurrence of spindles during the middle part of the expiration phase. A different coupling was observed between breathing and slow waves that were more distributed around both respiration phase transitions. Our findings suggest that breathing cycle influences the dynamics of brain activity during non-rapid-eye-movement sleep. This may enable sleep spindles to synchronize with other brain rhythms including hippocampus sharp wave ripples and facilitate information transfer between distributed brain networks. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Spindles and Wheels for yarn making at home. Change.org petition to protect Michigan's Farmland Straddle Creek Spins The Spanish Peacock Kromski Spinning Wheels Athena Spinning Wheels For used wheels, your best bet is one of the many social media groups set up for buying and selling them. Canadian Production Wheels Twisted Sister Sock Workbook The Mitten Handbook Shave 'Em to Save 'Em

Drop spindles? Only in a controlled manner

Brought to you by Eight Sleep's Pod Cover sleeping solution for dynamic cooling and heating, Magic Spoon delicious low-carb cereal, and LinkedIn Marketing Solutions marketing platform with 800M+ users.Matthew Walker, PhD (@sleepdiplomat), is professor of neuroscience at the University of California Berkeley and founder and director of the school's Center for Human Sleep Science. Dr. Walker is the author of the New York Times and international bestseller Why We Sleep: Unlocking the Power of Sleep and Dreams, which was recently listed by Bill Gates as one of his top five books of the year. His TED Talk, “Sleep is Your Superpower,” has garnered more than 17 million views.He has received numerous funding awards from the National Science Foundation and the National Institutes of Health and is a Kavli Fellow of the National Academy of Sciences. In 2020, Dr. Walker was awarded the Carl Sagan Prize for Science Achievements. Dr. Walker's research examines the impact of sleep on human health and disease. He has been featured on numerous television and radio outlets including 60 Minutes, Nat Geo TV, NOVA Science, NPR, and the BBC. Dr. Walker is also scientific advisor to Oura, a sleep-tracking ring.Dr. Walker hosts the 5-star-rated podcast The Matt Walker Podcast, which is all about sleep, the brain, and the body.And one last thing. UC Berkeley has given the rare approval for Matt's newly opened Sleep Center at the University to be named by an individual donor, or a named company, in perpetuity. If you are interested, please reach out to Matt and note that this opportunity is in the 7-figure range.Please enjoy!*This episode is brought to you by LinkedIn Marketing Solutions, the go-to tool for B2B marketers and advertisers who want to drive brand awareness, generate leads, or build long-term relationships that result in real business impact.With a community of more than 800 million professionals, LinkedIn is gigantic, but it can be hyper-specific. You have access to a diverse group of people all searching for things they need to grow professionally. LinkedIn has the marketing tools to help you target your customers with precision, right down to job title, company name, industry, etc. To redeem your free $100 LinkedIn ad credit and launch your first campaign, go to LinkedIn.com/TFS!*This episode is also brought to you by Magic Spoon cereal! Magic Spoon is a low-carb, high-protein, and zero sugar cereal that tastes just like your favorite sugary cereal. Each serving has 13–14g of protein, 4g of net carbs, and 0g of sugar. It's also gluten free, grain free, soy free, and keto friendly. And it's delicious! It comes in your favorite, traditional cereal flavors like Cocoa, Frosted, Peanut Butter, and Blueberry.Magic Spoon cereal has received a lot of attention since their launch. Time magazine included it in their list of Best Inventions of 2019, and Forbes called it “the future of cereal.” My listeners—that's you—get $5 off and a 100% happiness guarantee when you visit MagicSpoon.com/Tim and use code TIM. And some great news for Canadian listeners: Magic Spoon now also ships to Canada!*This episode is also brought to you by Eight Sleep! Eight Sleep's Pod Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.Go to EightSleep.com/Tim and save $250 on the Eight Sleep Pod Cover. Eight Sleep currently ships within the USA, Canada, the UK, select countries in the EU, and Australia.*[05:43] Sleep and sex.[23:45] Melatonin misgivings.[32:47] The suprachiasmatic nucleus.[36:08] Shrinking balls phenomenon.[41:47] Minimizing the time it takes you to sleep.[49:40] The bizarre basics of dreaming.[55:56] Taking a leap into lucid dreaming.[1:19:57] Optimizing sleep for learning.[1:43:14] Can sleep during an illness boost memory retention?[1:49:08] Massed versus spaced practice.[1:53:00] Using brain stimulation technology to enhance learning.[1:56:50] Optimizing memory replay.[2:02:47] Sleep and time dilation.[2:11:25] Today's "charlatan" science that may someday be vindicated.[2:17:44] Exercise and memory.[2:25:37] Staying hydrated without having to urinate all night.[2:29:13] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sadly, we are here to wrap up our final thoughts on Of Slippers and Spindles. Drew and Cassie return for one last episode to explain the sudden hiatus that began in December and has now led to the decision to end the show. In true Of Slippers and Spindles style, we each give three final book recommendations: three retelling novels we wanted to cover on the podcast and are disappointed we didn't get to. But before we go, we celebrate one major goal that we were able to accomplish! Thank you all so much for listening, supporting, and going on this journey with us! Join our community! View all of the benefits of joining our Patreon including the Official Of Slippers and Spindles Book Club, exclusive polls, monthly bookmarks, Zoom hangouts, and more! https://patreon.com/ofslippersandspindles Visit our our new merch store, Facebook group, Instagram, and more! https://linktr.ee/ofslippersandspindles We love to hear from you! You can reach us at ofslippersandspindles@gmail.com  Music: Through The Woods by Shane Ivers - https://www.silvermansound.com  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.07.527544v1?rss=1 Authors: Ansari, S., Gergely, Z. R., Flynn, P., Li, G., Moore, J. K., Betterton, M. D. Abstract: Fluorescently labeled proteins absorb and emit light, appearing as Gaussian spots in fluorescence imaging. When fluorescent tags are added to cytoskeletal polymers such as microtubules, a line of fluorescence and even non linear structures results. While much progress has been made in techniques for imaging and microscopy, image analysis is less well developed. Current analysis of fluorescent microtubules uses either manual tools, such as kymographs, or automated software. As a result, our ability to quantify microtubule dynamics and organization from light microscopy remains limited. Despite development of automated microtubule analysis tools for in vitro studies, analysis of images from cells often depends heavily on manual analysis. One of the main reasons for this disparity is the low signal-to-noise ratio in cells, where background fluorescence is typically higher than in reconstituted systems. Here, we present the Toolkit for Automated Microtubule Tracking (TAMiT), which automatically detects, optimizes and tracks fluorescent microtubules in living yeast cells with sub-pixel accuracy. Using basic information about microtubule organization, TAMiT detects linear and curved polymers using a geometrical scanning technique. Images are fit via an optimization problem for the microtubule image parameters that is solved using non-linear least squares in Matlab. We benchmark our software using simulated images and show that it reliably detects microtubules, even at low signal-to-noise ratios. Then, we use TAMiT to measure monopolar spindle microtubule bundle number, length, and lifetime in a large dataset that includes several S. pombe mutants that affect microtubule dynamics and bundling. The results from the automated analysis are consistent with previous work, and suggest a direct role for CLASP/Cls1 in bundling spindle microtubules. We also illustrate automated tracking of single curved astral microtubules in S. cerevisiae, with measurement of dynamic instability parameters. The results obtained with our fully-automated software are similar to results using hand-tracked measurements. Therefore, TAMiT can facilitate automated analysis of spindle and microtubule dynamics in yeast cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Disclaimer Subscribe to our Youtube Channel and like the video Subscribe to our Apple Podcast channel - https://podcasts.apple.com/us/podcast/habari-live/id1596526019 Visit our website www.habarientertainment.com Habari Live Podcast With Iesha and Dip! We bring you the news, Sports, and entertainment throughout the week, with great interviews with the most talented people in Phoenix Az. "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is permitted by copyright statutes that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use." Several nooses found Biden Student Debt Elections Arizona Scottsdale reclaimed water project Man pulled over with an Owl #PODCAST #BIDEN #ARIZONA #ELECTIONS #STUDENTDEBT #SCOTTSDALE #ACROSSTHESPIDER-VERSE #DEADPOOL3 #SUNS #blackpanther Pitch - Habari Entertainment uses hip-hop to introduce an enthralling spin on the news. The industry provides content and services suitable for everyone regardless of their temperament. We are one of the top online content creators with a mission to become the largest online news and talk network for the connected generation. At Habari Entertainment, we love to call ourselves the ‘hip hop generation newscast' and reflect that through our genuine hard work and dedication towards the media. We stand for informing the public with news and information that they can trust. Our motto is simple: we wish to update, inform, engage and YES, empower our listeners. At Habari Entertainment, we maintain standards, zero manipulation, straight facts, and open discussions- We're Habari Entertainment! We keep you updated with the reality. MISSION STATEMENT At Habari Entertainment, our mission statement is as follows: “To build a media company for the digital generation” --- Send in a voice message: https://podcasters.spotify.com/pod/show/damon-ellison4/message Support this podcast: https://podcasters.spotify.com/pod/show/damon-ellison4/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.08.523138v1?rss=1 Authors: Staresina, B., Niediek, J., Borger, V., Surges, R., Mormann, F. Abstract: Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain - in the absence of external stimulation or conscious effort - controls neuronal firing rates (FRs) and communication within and across circuits, supporting synaptic and systems consolidation. Using intracranial Electroencephalography (iEEG) combined with multiunit activity (MUA) recordings from the human hippocampus and surrounding medial temporal lobe (MTL) areas, we here show that governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples to occur. This sequential coupling leads to a stepwise increase in (i) neuronal FRs, (ii) short-latency cross-correlations among local neuronal assemblies and (iii) cross-regional MTL interactions. Triggered by SOs and spindles, ripples thus establish optimal conditions for spike-timing dependent plasticity and systems consolidation. These results unveil how the coordinated coupling of specific sleep rhythms orchestrates neuronal processing and communication during human sleep. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

On today's episode of Raising the Nuts, Jody and Trevor discuss fight clubs, a man who paid 16k to become a dog, and peach milkshakes from Chick-Fil-A in their anything but bad news segment. They also talk about the Idaho murder case and how each of them filters out the news. Trevor goes on a lengthy tangent about poker struggles and Jody talks about her excitement in renovating our stairs. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.19.521088v1?rss=1 Authors: Pedrosa, R., Nazari, M., Kergoat, L., Bernard, C., Mohajerani, M., Stella, F., Battaglia, F. Abstract: During NREM sleep hippocampal Sharp-wave ripples (SWR) events are thought to stabilize memory traces for long-term storage in downstream neocortical structures. Within the neocortex, Default Mode Network (DMN) areas interact preferentially with the hippocampus purportedly to consolidate those traces. Transient bouts of slow oscillations and sleep spindles in DMN areas are often observed around SWRs, suggesting that these two activities are related and that their interplay possibly contributes to memory consolidation. To investigate how SWRs interact with the DMN and spindles, we combined cortical wide-field voltage imaging, ECoG, and hippocampal LFP recordings in anesthetized and sleeping mice. Here we show that, during SWR, ''up-states'' and spindles reliably co-occur in a cortical subnetwork centered around the Retrosplenial cortex. Furthermore, Retrosplenial transient activations and spindles predict Slow Gamma oscillations in CA1 during SWRs. Together, our results suggest that Retrosplenial-hippocampal interaction may be a central source of information exchange between cortex and hippocampus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.19.521088v1?rss=1 Authors: Pedrosa, R., Nazari, M., Kergoat, L., Bernard, C., Mohajerani, M., Stella, F., Battaglia, F. Abstract: During NREM sleep hippocampal Sharp-wave ripples (SWR) events are thought to stabilize memory traces for long-term storage in downstream neocortical structures. Within the neocortex, Default Mode Network (DMN) areas interact preferentially with the hippocampus purportedly to consolidate those traces. Transient bouts of slow oscillations and sleep spindles in DMN areas are often observed around SWRs, suggesting that these two activities are related and that their interplay possibly contributes to memory consolidation. To investigate how SWRs interact with the DMN and spindles, we combined cortical wide-field voltage imaging, ECoG, and hippocampal LFP recordings in anesthetized and sleeping mice. Here we show that, during SWR, ''up-states'' and spindles reliably co-occur in a cortical subnetwork centered around the Retrosplenial cortex. Furthermore, Retrosplenial transient activations and spindles predict Slow Gamma oscillations in CA1 during SWRs. Together, our results suggest that Retrosplenial-hippocampal interaction may be a central source of information exchange between cortex and hippocampus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.06.519290v1?rss=1 Authors: Conessa, A., Debarnot, U., Siegler, I., Boutin, A. Abstract: Sleep benefits the consolidation of motor skills learned by physical practice, mainly through periodic thalamocortical sleep spindle activity. However, motor skills can be learned without overt movement, either through motor imagery or action observation. Here, we investigated whether sleep spindle activity also supports the consolidation of non-physically learned movements. Forty-five electroencephalographic sleep recordings were collected during a daytime nap after motor sequence learning by physical practice, motor imagery or action observation. Our findings revealed that irrespective of the modality of practice, spindles tend to cluster in trains on a low-frequency time scale of about 50 seconds, and during which spindles iterate every 3-4 seconds. However, despite this apparent modality-unspecific temporal organization of sleep spindles, different behavioral outcomes were elicited. We show that a daytime nap offers an early sleep window that promotes the retention of the learned motor skill following PP and MI practice, and its generalizability towards the transfer of skill from one effector to another after AO practice. Altogether, we demonstrated that the temporal cluster-based organization of sleep spindles may be a general mechanism for effective memory reprocessing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518200v1?rss=1 Authors: Boutin, A., Gabitov, E., Pinsard, B., Bore, A., Carrier, J., Doyon, J. Abstract: Sleep benefits motor memory consolidation, which is mediated by sleep spindle activity and associated memory reactivations during non-rapid eye movement (NREM) sleep. However, the particular role of NREM2 and NREM3 sleep spindles and the mechanisms triggering this memory consolidation process remain controversial. Here, simultaneous electroencephalographic and functional magnetic resonance imaging (EEGfMRI) recordings were collected during night-time sleep following the learning of a motor sequence task. Adopting a time-based clustering approach, we provide evidence that spindles iteratively occur within clustered and temporally organized patterns during both NREM2 and NREM3 sleep. However, the clustering of spindles in trains is related to motor memory consolidation during NREM2 sleep only. Altogether, our findings suggest that the clustering and rhythmic occurrence of spindles during NREM2 sleep may serve as an intrinsic rhythmic sleep mechanism for the timed reactivation and subsequent consolidation of motor memories, through synchronized oscillatory activity within a subcortical-cortical network involved during learning. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Hey campers, we are going to be learning about the strange and unusual Rumplestiltskin in this week's bonus episode! And to make this episode even more special we have the hosts  from Of Slippers and Spindles podcast as guests with us this week. So take a seat around the campfire as Kimmy, Ryan, Drew, and Cassie dive into some amazing storytelling voice acting, Rumplestiltskin's killer disappearing act, and everyone's true feelings on the Once Upon a Time series. We hope you enjoy this episode of Aloreing, oh and remember campers, learn to use a spindle just in case, and if getting what you want depends on a person guessing your name DON'T go shouting your name in song until the deal is done. . Check out Of Slippers and Spindles Today!

Hello! :) I'm so excited so many of you enjoyed the relaxing mansion tour! Here is the highly requested follow up with some extended footage and I also included some other trigger sounds from the house that I thought looked or sounded good. I hope you will enjoy! 00:52 Lamp One 02:11 Painting One 03:51 Encyclopedia 06:40 Lamp Two 07:44 Painting Two 08:49 Shakespeare 10:41 Tapestry 11:55 Spindles 12:57 Chair 13:35 Chess board 14:30 Sink 15:10 Vanity 16:03 Curtains 17:21 Mirror 18:22 Dali Elephant 19:39 Couch 20:16 Outside Thank you for being here! :) #ASMR #GentleWhispering #housetour 3/12/20 --- Send in a voice message: https://anchor.fm/maria-gentlewhispering/message Support this podcast: https://anchor.fm/maria-gentlewhispering/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.507471v1?rss=1 Authors: Dickey, C. W., Verzhbinsky, I. A., Kajfez, S., Rosen, B. Q., Pati, S., Halgren, E. Abstract: The co-occurrence of brief ~90 Hz oscillations (co-ripples) may be important in integrating information across the cortex and hippocampus, essential for sleep consolidation, and cognition in general. However, how such co-ripples are synchronized is unknown. We tested if cortico-cortical and hippocampal-cortical ripple co-occurrences are due to the simultaneous direct propagation of thalamic ripples, or if they are instead facilitated by lower frequency waves. Using human intracranial recordings, we found that ripples are generated in the thalamus during non-rapid eye movement sleep with similar characteristics as cortical and hippocampal ripples. However, thalamic ripples only infrequently and weakly co-occur, and never phase-lock, with cortical and hippocampal ripples. In contrast, thalamo-cortical spindles and upstates strongly facilitated cortico-cortical and hippocampo-cortical co-rippling. Thus, while thalamic ripples may not directly drive multiple cortical or hippocampal sites at ripple frequency, these sites may ripple synchronously in response to widespread activation from thalamo-cortical spindles and upstates. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

This month we read and review Blade Breaker by Victoria Aveyard! Like all of our reviews, the first part is spoiler free. We are joined by special guest, our friend Leah of YA Book Chat! You can check out her show by following that link. Here's a little about Blade Breaker:Fighting beside her band of unlikely companions, Corayne is learning to embrace her ancient lineage and wield her father's powerful sword.But while she successfully closed one of the Spindles, her journey is far from over.Queen Erida's army marches across Allward with her consort, Taristan, right beside them, opening more portals into nightmarish worlds, razing kingdoms to the ground.Corayne has no choice but to assemble an army of her own if she's to save the realm as she knows it. But perilous lands await her and the companions, and they face assassins, otherworldly beasts, and tempestuous seas all as they rally a divided Ward to fight behind them.But Taristan has unleashed an evil far more wicked than his corpse armies. Something deadly waits in the shadows; something that might consume the world before there's any hope for victory. We hope you enjoy this episode!Do you have a book you'd like us to review on this show? Want to give us some feedback? Send us an email at badassliteraturesociety@gmail.comIf you don't already, follow us on Instagram and FacebookAll music from hooksounds.comArt by Justin Miller DesignCheck us out here!

We review all the previous episodes. Answer questions. Discuss Boundaries vs. Bill of Rights and how the Bill of Rights are the truths that help you decide and keep your boundaries. How to support ourselves as we get push-back from others around us when making boundaries–always go to the Lord for your answers, validations, clarifications, to figure out your weaknesses, etc. The 2 Spindles of our Personal Liahona: 1) Bill of Rights (The directions to go) and 2) Value System (The direction you are going). Examples of how to analyze ourselves and our own boundaries with the Lord. --- Support this podcast: https://anchor.fm/motherswhoknow/support

We cover everything the past weekend and this week so far that has happened in the racing world, from fist fights to flips at Stafford, Thunder Road, Berlin, Jennerstown and much more including spindles that dont belong with cars, rule amendments halfway through the season, lead blocks, fist fights, suspensions etc tune in !

Follow Dr. Kokkinos on Twitter: @VasKokkinosRead his paper here: https://doi.org/10.1016/j.clinph.2021.09.008 If you would like to get in touch with the show our email is: clinicalneuroasktheexperts@gmail.com Links to the Internal Federation of Clinical Neurophysiology Social MediaTwitter - https://twitter.com/ClinicalNeuroph/Facebook - https://www.facebook.com/ClinicalNeurophysiology/Instagram - https://www.instagram.com/clinicalneuroph/Linkedin -https://www.linkedin.com/in/ClinicalNeurophysiology/detail/recent-activity/

The fitness industry has tried to wrongly convince you that checking off a list of exercises is the same as gaining and applying scientific knowledge…  Since you are here, you know that there is something more to gain by thinking for yourself and being empowered by fitness. The trainer toolbox interview for this season of TFBF is with George Grose, an Exercise Professional that works with clients and a published author on eccentric exercise fatigue and sensory input. Topics discussed: Grose's fitness journey Continuum training  Thought process and decision making as a trainer Improving the sensation of upper body exercises  Spindles and GTO Navigating client relationships and the investment of your time SUBSCRIBE: Subscribe to the podcast to make sure you never miss an episode.   You can find us on a variety of podcast apps: Spotify Pandora iHeartRadio Amazon music TuneIn Google podcasts   Connect with George Grose: LinkedIn Instagram Website   Connect with Jennifer Schwartz: Website Instagram Twitter   WRITE A REVIEW and WIN: Leave us a rating and a written review on iTunes so more listeners can find us.   Screenshot and send it to hello@thinkfitbefitpodcast.com

Ja Morant is a Superstar, there's no ifs, and or buts about it. With teammates fighting each other (Trezz & KCP wyd!?), Josh Giddey throwing time-warping passes and Spindles Ingram banging in game-winning 3s, Ja stood head and shoulder above everyone today as he took over late & ensured a HUGE Grizzlies win over the Warriors. ALSO, the Denver Nuggets had one of the most epic melt downs you'll ever see, AND the latest on Ben Simmons. THAT MEANS we're talking ALL the latest NBA news & goss, plus EVERY GAME from today covered in the NBA STRAYA GAME WRAPS, Plus, THAT'S NOT A KNIFE, OLD MATE NO MATES, SPUD OF THE NIGHT, PANTSING OF THE EVENING and BETTER THAN LONZO BALL!! PLUS! YEAH NAHs -- Is Joker being disrespected in the MVP conversation? Are the Grizzlies this year's version of the Hawks from last season?!?!? -- UNPOPULAR OPINION OF THE DAY and an OUTBACK TAKEHOUSE... As well as the STRAYAN PLAYER WATCH! There's a GREAT return from GREAT MOMENTS IN NBA STRAYA STAT HISTORY... PLUS, EVERY SINGLE NBA GAME TOMORROW is previewed & picked for you! Nine games, and there are some absolute RIPPERS in there. And that's it - sorry for the late show today... but hey, you get that on the big jobs. fun one today! - enjoy!

Our guest on today's podcast is Elliott May, engineer at BME in Port Huron, Michigan. BME builds original custom attachments for cam multi-spindles. They also rebuild Acme-Gridley screw machines. Elliott and I talked about a lot of fascinating things in this interview. How to keep old mechanical beasts relevant, getting young people into machining, and […] The post Attached to Multi-Spindles, with Elliott May—EP. 143 first appeared on Today's Machining World.

"How can you know what you want 'til you get what you want and you see if you like it?" Our journey through Into the Woods continues! This week, Drew and Cassie look at how Into the Woods has been adapted in a few different ways. First we break down the 2014 film starring Meryl Streep, James Corden, Emily Blunt, Anna Kendrick, and Chris Pine. We discuss the adaptations between mediums in general, Disney's changes to the Narrator and the Mysterious Man, the changes to important songs like On the Steps of the Palace, giving away plot twists too early, Johnny Depp as the Wolf, the brilliance of Agony, the cuts they made like No More, and much more. Then we talk about Broadway Junior, which adapted the first act of Into the Woods to be performed by children. Cassie gets on her soapbox about very existence of the Broadway Junior collection and then we get pretty meticulous with exactly what was eliminated in order to turn the musical into a 60-minute... skit. We also briefly touch on the illustrated book by Hudson Talbott and a couple of interesting changes he made. And yeah, we get super dramatic about all of it, but it's because we CARE!Of Slippers and Spindles is not a spoiler-free podcast, so we do recommend watching Into the Woods before listening to the episode because we're not going to explain the story in as much detail as we usually do, since we've already done so this month. But we do want to let you know that in this particular case,  watching these particular versions may not be necessary! Viewing Disney's movie in advance may help to follow along, but you do not need to seek out Into the Woods, Jr. or the Hudson Talbott book unless you wish to!In today's episode, Drew references the YouTube video "Adaptation, Brand, and Into the Woods" by Zack Paslay - https://youtu.be/1736u5QdVKUMusic: Through The Woods by Shane Ivers - https://www.silvermansound.com

Today, we talk about different types and history of deck railings --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/allabouthomeconstruction/message Support this podcast: https://anchor.fm/allabouthomeconstruction/support

Nick makes the first real parts on his HAAS, Aaron gets some shiny hydraulic toolholders and on the same day destroys an ER collet holder. Nick learns about CNC spindles, and Aaron yammers on about Space!!Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Join Podcast Father on his journey as the Indie Podcaster. Episode #10 Creator Spotlight: Courtney Larsen, They Call Me Spindles from Spindles Design Co. Courtney is an Artist and Entrepreneur of Spindles Design Co. She creates one of a kind wedding (decor) stationery; wedding invitations and paints statement murals. Jeff (Podcast Father) and Courtney discuss her creative journey and some of the challenges she went through to become a successful artist and to manage her own business. Thank you for listening and supporting independent creators! https://www.spindlesdesignco.com/ (Check out Courtney's business here.) https://quitethethingmedia.com/podcastfather/ (Check out Podcast Father & the Quite The Thing Media Team.) https://www.yungkartzbeats.com/ (All music credited to artist Yung Katz, check out the site here.) https://linktr.ee/Goodpods (Make sure you've downloaded and listen on the Goodpods app.)

Church of Jesus Christ Study Session seeks to generate reflection about areas in the Restored Gospel. Whether it's Come Follow Me, a General Conference talk or a recent Gospel Topic, hopefully you'll find something to keep the Spirit of Christ in your life. Twitter - @mattsroberts90 ldsstudysession@gmail.com You can also join the discussion in the Facebook Group 'Church of Jesus Christ Study Session with Come Follow Me'. You can purchase my book, From Father to Child: Raising a Child to Spiritual Strength in Generation Alpha at the link here: https://www.amazon.co.uk/Father-Child-Spiritual-Strength-Generation-ebook/dp/B08DRLWWZD/ref=mp_s_a_1_3?dchild=1&keywords=from+father+to+child&qid=1596387393&sr=8-3

Maggie Casey and Judy Steinkoenig are well known as teachers and writers. Almost every day for 28 years, you would have found one or both of them behind the counter or helping customers at their store, Shuttles, Spindles & Skeins in Boulder, Colorado. The retail store closed in early 2020, and as they plan their next projects, they sat down to tell us about the behind-the-scenes truths of owning a yarn store. Is it as delightful or as difficult as people might imagine? What’s the strangest request they ever got? What was the hardest decision they ever faced together? We got the inside scoop.

Of Slippers and Spindles is taking an indefinite hiatus while Drew deals with some health issues. We hope to be back with you soon.

*ch ch ch, ah ah ah* Today, Ross Lampert kicks down our podcast door to talk about the aquatic antagonist of Camp Blood and everyone's favorite momma's boy: Jason Voorhees. For more information on Dagger and Ink, please visit: https://daggerandink.com/ For more information on The Tank, please visit: https://thetanknyc.org/ Other podcasts we recommend supporting:Knight Cap Audio PlaysThe Reincarnated Radio PodcastSay Hello!The Amateur Detective ClubPitch This PodcastThis Podcast Won't Run A WeekThe Green Onion InitiativeOf Slippers and Spindles

This week, Maggie and V are joined by Drew and Cassie from the Of Slippers and Spindles Podcast to talk about fanfiction, fairytales, and folktales! They discuss centuries of stories, ridonkulous plotlines, anonymous pen pals, and of course, the ways that transformative works of all kinds help humanity hold onto its soul through dark and troubled times.

Some machining applications need more torque than others, and gear head spindles can provide it. In this episode, Alan Rooks, Editor in Chief of Manufacturing Engineering magazine, talks with Nick St. Cyr, Product Manager for Methods Machine Tools about gear head spindle and why machine shops may need them; the different styles of gear head spindles; the principal applications that require gear head Spindles; the main benefits of a gear head spindle; the programming challenges when using a gear head spindle; and the other features of the machine need to be taken into consideration for a machine with a gear head spindle.

Episode #201 is brought to you by these Rad Ass Sponsors -  www.classicperform.com - Spindles, Brakes, Lowering and more - Use "C10 Talk" at check out to save 10% off your total order. www.brothertrucks.com - Parts, and DIY videos, check out their YouTube for help and answers.  www.vintageair.com - The Leader in aftermarket Heat/AC for your truck.  www.mar-k.com - The absolute BEST trim for your truck - Made in the USA! www.painlessperformance.com - Is it time to rewire that chassis? Painless has a set up for you and your truck.  Interviews from the 10th annual Dino's Git Down in Glendale Arizona.  Over 2000 Chevy trucks embark on Westgate Entertainment District for nothing but Rad Rides and People that match! 

Well. . . .  we back at it again, ushering you through another collection of words like sneaky little cashmere merchants. What? You thought we caught the COVID-19 Pandemavirus? ha yeah right, Think again pal. You gotta be quicker then that BROVID-19 to catch me and my compatriot Lil Spindles. Look in full transparency we didn't record this recently, We dry reached back through the anal's of time and tobogganed through the archives. We learnt a lot as we gracefully swanned through our archives. First lesson we learnt is don't talk about the archives with the witnesses, they are not ready. Anyway enough small talk, sit back, relax, grab a drink, take a sip, grab the wheel again you reckless fool, you're driving for peat sake put the drink down and focus on the road. Y'all wild as hell. let us cleanse your mind and your souls with our tiny team of word cleaners. Music: Dad Hat - Young Dad Buy it here: https://music.apple.com/us/artist/young-dad/419856938 Follow Royce here: twitter.com/ThaChoice22 For Business Inquiries: docketlikewetalkit@gmail.com FACEBOOK: https://www.facebook.com/DocketLikeWeTalkIt TWITTER: twitter.com/DockLikeWeTalk twitter.com/Moony_Shitai_Jr twitter.com/Juntdaddy TWEET US! #DocTalk #ToppenOff #Topt

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.25.354282v1?rss=1 Authors: Lemke, S. M., Ramanathan, D. S., Darevsky, D., Egert, D. G., Berke, J., Ganguly, K. Abstract: Plasticity within the corticostriatal network is known to regulate the balance between behavioral flexibility and automaticity. Repeated training of an action has been shown to bias behavior towards automaticity, suggesting that training may trigger activity-dependent corticostriatal plasticity. However, surprisingly little is known about the natural activity patterns that may drive plasticity or when they occur during long-term training. Here we chronically monitored neural activity from primary motor cortex (M1) and the dorsolateral striatum (DLS) during both training and offline periods, i.e., time away from training including sleep, throughout the development of an automatic reaching action. We first show that blocking striatal NMDA receptors during offline periods prevents the emergence of behavioral consistency, a hallmark of automaticity. We then show that, throughout the development of an automatic reaching action, corticostriatal functional connectivity increases during offline periods. Such increases track the emergence of consistent behavior and predictable cross-area neural dynamics. We then identify sleep spindles during non-REM sleep (NREM) as uniquely poised to mediate corticostriatal plasticity during offline periods. We show that sleep spindles are periods of maximal corticostriatal transmission within offline periods, that sleep spindles in post-training NREM reactivate neurons across areas, and that sleep-spindle modulation in post-training NREM is linked to observable changes in spiking relationships between individual pairs of M1 and DLS neurons. Our results indicate that offline periods, in general, and sleep spindles, specifically, play an important role in regulating behavioral flexibility through corticostriatal network plasticity. Copy rights belong to original authors. Visit the link for more info