Podcast appearances and mentions of Reid Hoffman

Vinny Lingham is a Bitcoin OG who pioneered gift card payments in 2012 with Gyft, served on the board of the Bitcoin Foundation, spearheaded blockchain identity verification with CIvic, and in more recent years moved on to managing risk with Praxos Capital. Thanks to some of his accurate price predictions, Vinny has also received the nickname "The Oracle". In this episode, we talk about his Bitcoin journey and how his views have evolved over the last 14 years. Time stamps: 00:01:06 Intro & sponsors: Vinny Lingham, 15 years in Bitcoin 00:02:04 Gyft: a dozen companies and one gift card problem 00:02:26 Chargebacks, stolen cards & getting attacked by scammers 00:04:13 Why Bitcoin looked like the perfect payment rail 00:04:51 Zero-conf payments and the first-seen rule 00:05:48 The Starbucks and McDonald's signature math 00:06:51 100,000 Bitcoin payments, zero double spends 00:07:13 Civic's Bitcoin patents & the 2017 fee explosion 00:07:37 Blockstream, Adam Back, MIT and the Epstein files 00:08:10 Core keeps pruning dissenting voices 00:08:55 Why Bitcoin still can't be the whitepaper's payment system 00:09:08 Counterparty, Mastercoin & the birth of Ethereum 00:09:34 "Nothing has happened in Bitcoin in five years" 00:10:16 Why he went and backed Solana instead 00:10:23 Sympathy for BIP 110 over Core 00:11:08 Inscriptions can be done many ways 00:12:27 "Lightning will be ready in 18 months" forever 00:13:26 Drivechains, BIP 300 & the Ecash fork paying miners 00:14:44 UX, mainstream users and idiot-proof money 00:15:17 People who don't know you can hold BTC outside an ETF 00:15:27 Is the ETF the real scaling layer? 00:15:37 What Vinny signed up for when he read the whitepaper 00:16:30 Wayne Vaughn in the chat 00:16:48 Saylor's Bitcoin Security Consortium and the $15M 00:17:24 Saylor argues against bigger blocks and covenants 00:17:49 How is this different from the Bitcoin Foundation? 00:18:36 Saylor as systemic risk: crashing the minority fork 00:19:43 Losing SPV and the simplicity of early Bitcoin 00:20:48 When did you last actually use Bitcoin? 00:21:22 Six confirmations vs Apple Pay 00:21:41 Gyft's customers who had no credit cards 00:22:07 Not a store of value: a store of liquidity 00:23:24 So what is a store of value, exactly? 00:26:00 The 100 year test: one ounce of gold buys one suit 00:27:09 Does the whitepaper ever say "digital gold"? 00:27:53 Saylor's redefinition: expensive to move, held by institutions 00:28:08 Privacy, tiny payments and why volume creates stability 00:28:42 Exchanges are layer two, Lightning is layer three 00:29:06 Solana at the World Series of Poker 00:30:07 BSV, Teranode, BCH and who actually handles volume 00:30:58 Does everyone really need to run a node? 00:31:30 Luke Dashjr, 16MB blocks and 50 billion Catholics 00:33:34 Arguing with someone who redefines words 00:34:33 How did Blockstream become so politically powerful? 00:35:40 Reid Hoffman's $20 million 00:36:26 Reading the Epstein files with Bitcoin eyes 00:36:45 Tether won the global south instead 00:37:42 "The community is people who never built anything" 00:38:00 Why Elon Musk walked away from Bitcoin 00:39:07 The ESG excuse & the Bitcoin Mining Council 00:40:05 Elon on bandwidth, latency and second layers 00:41:03 Why Civic started on Bitcoin and left 00:42:05 Multicoin, the Solana seed round & founding Praxos 00:42:29 Why "Civic" and not "Supra" 00:42:46 Nobody wants identity: crypto's actual number one use case 00:44:03 Zcash's comeback, Ironwood & the auditable supply 00:45:34 Delistings and the headwinds facing privacy coins 00:46:06 Why Zcash chose DeFi rails over merchant adoption 00:47:07 How to know you're in a bear market 00:47:25 Elgamarov & how small this world really is 00:48:10 What does Vinny actually hold today? 00:49:27 Praxos: delta neutral, funding rates and volatility 00:51:44 Sponsors: Braiins, Cake Wallet, SideShift, LayerTwo Labs, Orange Rock 00:54:40 Wayne Vaughn's question: will the CLARITY Act pass? 00:56:47 Michael Saylor and the Strategy problem 00:57:14 The GBTC discount scenario 00:58:16 Why August could be a bloodbath 01:01:56 Node counts, sybil attacks and hash rate 01:03:16 The rewritten history of SegWit and SegWit2x 01:04:19 How Bitcoin Cash became the fallback plan 01:04:59 Gavin Andresen and the word "bamboozled" 01:06:00 Was Craig Wright involved at all? 01:08:04 Hal Finney's logs and the Van Nuy, California IP address 01:08:55 GMX, German privacy law and the missing paper trail 01:11:17 Roger Ver, the checksum test and Craig 01:13:00 Asking Claude who Satoshi is 01:14:17 The case for Nick Szabo and the trusted third parties 01:15:31 The counterfactual: what if Bitcoin had scaled? 01:19:35 Tron, USDT and five years of outperforming BTC 01:20:09 Bitcoiners understand supply, not demand 01:20:36 What happens when the block rewards run out 01:21:15 Rentable SHA256 and the state actor attack scenario 01:22:54 Will Vinny claim the August fork airdrops?

This Week In Startups is made possible by: YSecurity https://YSecurity.io/TWIST MongoDB https://MongoDB.com/ai Odoo https://Odoo.com/twist Today's show: AI models can solve PhD-level math equations and code an app in minutes… So why does everything they design look like identical slop? Thais Castello Branco, founder of Taste Labs, raised $18.5M in seed funding to teach frontier models about aesthetics and outputting quality content. She talks to Jason and Lon about why even frontier models regress to the mean on subjective tasks, how paid "TasteMakers" can improve output quality, and whether AI accelerates or destroys the half-life of "what's cool." PLUS Leopold Aschenbrenner's AI hedge fund liquidated its public stock portfolio, but it may be too soon to count this 25-year-old completely out. Google Earth adds AI generation and turns into a misinformation factory. LinkedIn and Substack join the AI slop crackdown. And why does every venture capitalist seem to have an opinion about the Ceuta border crisis? Guest Thais Castello Branco on X: https://x.com/thaiscbranco_ Taste Labs: https://tastelabs.com/ Amplify Partners: "Kill the Slop": https://www.amplifypartners.com/blog-posts/kill-the-slop-announcing-our-investment-in-taste Relevant Links Leopold Aschenbrenner's essay "Situational Awareness": https://situational-awareness.ai/ CNBC on SA fund collapse: https://www.cnbc.com/2026/07/31/leopold-aschenbrenner-situational-awareness-fund-fire-sale.html Henk van Ess thread on Google Earth + Nano Banana: https://x.com/henkvaness/status/2082912544394498228 Substack CEO Chris Best: "Against Claudefishing": https://post.substack.com/p/against-claudefishing NPR on the Ceuta crisis: https://www.npr.org/2026/07/31/g-s1-136507/morocco-spain-migration Ethan Goodhart's self-driving golf cart post: https://x.com/EthanGoodhart/status/2082136189998682598?s=20 "Wind" app on TestFlight: https://testflight.apple.com/join/zZqmhhwf TechCrunch: "Gritt exits stealth": https://techcrunch.com/2026/07/21/gritt-exits-stealth-with-34-million-for-robots-to-build-solar-plants-then-everything-else/ CA Gov: Project Nexus solar-covered canal announcement: https://www.gov.ca.gov/2026/04/29/governor-newsom-announces-the-completion-of-first-of-its-kind-solar-covered-canal-in-the-central-valley-piloting-a-new-way-to-save-water-and-reduce-costs/ Molly Wood's "Everybody in the Pool" podcast: https://www.everybodyinthepool.com/ Timestamps:   0:00 Coming up on today's show… 1:23 Thais Castello Branco on teaching models to have good taste 10:45 YSecurity - The on-demand security team for startups. Need enterprise-grade security without hiring a $400k CISO? YSecurity gives you 40+ expert engineers, matched to exactly what you need, by the hour, with your first six hours completely free. Go to https://YSecurity.io/TWIST 15:19 The "TasteMaker" community of paid human curators 20:37 MongoDB - AI-assisted and agentic coding is helping you build faster than ever. Start building at https://MongoDB.com/ai 24:40 Jason's personal "cool hunter" prompt 30:16 Odoo - The all-in-one business platform. Get started for free at https://Odoo.com/twist 37:36 Situation Awareness lacked situational awareness 46:59 Claude models hacked three external organizations 50:54 Google Earth adds Nano Banana for some reason 54:24 The AI Slop crackdown spreads 57:54 Too many opinions about the Ceuta migrant crisis 1:04:05 Self-driving golf carts and also cars 1:09:53 Robot arms are installing solar panels   Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

After his first VC-backed business flopped, ButcherBox CEO and founder Mike Salguero turned lessons learned the hard way into the fuel that built his subscription meat delivery business. Salguero joined host Jeff Berman to reveal how a blend of clean ingredients, clever marketing, and hiring for grit helped him scale into a business that's now making more than $600M a year and expanding into retail nationwide. Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Northwest Registered Agent- NorthwestRegisteredAgent.com/twist Odoo - Odoo.com/twist MongoDB - MongoDB.com/ai   Today's show: The FCC's decision to ban Chinese humanoid robots over security concerns is a boon to American startups, which now face a narrower competitive market. But where should we draw the line on security over competition? Menlo Ventures' Deedy Das, Weisburd Pierce's David Weisburd, Plexo Capital's Lo Toney, and LAUNCH's Jason Calcanis broke down how they differentiate between legitimate security concerns and purported regulatory capture. Today's venture capital roundtable also dug into OpenRouter's possible sale to Stripe, changing tokenomics, the Indian market for startups, and even DoorDash's drone-delivery business taking flight. Guest Links: Deedy Das https://x.com/deedydas Menloe Ventures https://menlovc.com/ Lo Toney https://x.com/lo_toney Plexo Capital https://www.plexocap.com/ David Weisburd https://x.com/DWeisburd Weisburd Pierce https://www.weisburdpierce.com/ Jason Calcanis https://x.com/Jason LAUNCH https://launch.co/ Show Links: The FCC's decision regarding Chinese robots https://www.fcc.gov/document/fcc-adds-foreign-produced-power-inverters-and-robots-covered-list-0 Pacing the Frontier letter https://www.pacingthefrontier.com/ Cursor Start https://cursor.com/blog/cursor-start-india Stripe may buy OpenRouter https://www.axios.com/2026/07/24/stripe-openrouter-merger-ai-currency OpenRouter financials https://www.theinformation.com/articles/openrouter-financials-suggest-steep-price-possible-acquirer-stripe?rc=g3wfdp Kimi K3 license https://huggingface.co/moonshotai/Kimi-K3/blob/main/LICENSE Pangram https://www.pangram.com/ Tau Robotics https://www.tau-robotics.com/ Zipline https://www.zipline.com/ Manna https://www.manna.aero/ Kindred Ventures https://kindredventures.com/ Autolane https://goautolane.com/ Salmon Labs https://salmonrun.ai/   Timestamps: 0:00 The FCC bans Chinese humanoid robots 2:18 Waymo, Uber, Robotaxi, and the global BYD threat 10:30 MongoDB - AI-assisted and agentic coding is helping you build faster than ever. Start building at https://MongoDB.com/ai 15:45 The "Pacing The Frontier" letter (1,100+ AI staffers warn on RSI) 19:51 Odoo - The all-in-one business platform. Get started for free at https://Odoo.com/twist 21:07 Regulatory capture vs. genuine concern 30:09 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 37:57 Have we reached AGI? 38:35 Stripe eyes OpenRouter at $10B 39:19 Does OpenRouter have a moat? 47:13 Kimi K3's license and neocloud margins 49:34 Claude Tag and the future of AI-mediated workplaces 53:26 Cursor Start, ChatGPT Go, and the India market 1:02:03 Have we solved AI detection? 1:11:20 Tau Robotics $30/hour robotic housecleaning 1:12:49 Job loss, and the social safety net 1:18:25 DoorDash Air takes on Zipline, Manna 1:21:00 Portfolio shout-outs Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Visual artist and brand content creator Joe Salvatore joins Reid Hoffman and Parth Patil to explain how AI is turning creative professionals into orchestrators of systems rather than makers of one piece at a time. Joe spent four years chasing every new image and video model out of pure creative curiosity before Parth pushed him to take a step back and become a director of these tools. He traces that shift, from generating a single image, to making 200, to running fully automated ad campaigns through Codex, and explains why the critical skill turned out not to be technical at all. As he puts it, he can outsource production, but he can't outsource his taste. He walks through a live campaign for Ketone-IQ, using a Hermes agent to research decades of proven advertising styles, then chaining models together to generate and grade hundreds of on-brand variations overnight. He and Parth get into how a shared creative agent learns from everyone it works with, why articulating an idea clearly has become the differentiator, and how AI made the gap between a sloppy brief and a tight one impossible to hide. Reid, Parth and Joe close on Wittgenstein, and why language no longer just describes the world but summons it. Referenced in episode: the Lord of the Rings x Wes Anderson AI trailer: https://www.youtube.com/watch?v=KrjL_TSOFrI

Serena Williams doesn't just defy convention on the court. She's also applying her competitive mindset to entrepreneurship and venture investing, recently rebranding her firm from Serena Ventures to StarFire Ventures. Serena joins Bob Safian to discuss how she identified the 16 unicorns now in her portfolio, what she looks for in founders, and how partnerships with companies from Nike to Ro fit into her broader vision. Recorded live at the Reckitt Catalyst event in Palm Beach, Serena also opens up about balancing business with family life—and why she still feels the pull of the tennis court.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Every.io https://every.io MongoDB https://MongoDB.com/ai Agree https://agree.com Today's show: *Most lab-grown meat companies have already gone under. It's expensive to produce, and there's little demand from real-world consumers. But Tokyo's IntegriCulture is still standing after selling their proprietary serum to cosmetics companies. On Episode 3 of TWiST from Tokyo, Jason sits down with Dr. Yuki Hanyu, an Oxford-trained chemist who started a DIY meat movement out of a comic convention and turned it into Japan's first cell-cultured protein company. PLUS why the cultivated meat market stalled out, why producing a "slurry of cells" is more efficient than jumping right to muscle tissue, the regulatory framework in Japan vs. the US, and… is it fair to call this "meat"? Or is it something else entirely? Guest Yuki Hanyu on LinkedIn: https://www.linkedin.com/in/yuki-hanyu-b860bb34/ IntegriCulture: https://integriculture.com/en/ Relevant Links: AG Funder News: "IntegriCulture turns a profit": https://agfundernews.com/cell-ag-picks-shovels-pioneer-integriculture-turns-a-profit-but-cautions-that-as-long-as-cell-ag-remains-so-capital-intensive-it-will-be-difficult-to-take-off Vegconominst: Cultivated duck liver coverage: https://vegconomist.com/cultivated-cell-cultured-biotechnology/cultivated-meat/japans-integriculture-products-cultivated-duck-liver/ Cellament skin care ingredient: https://www.cellament.jp/cellament-en?lang=en Medium: Shojinmeat Project: https://medium.com/shojin-meat Cellular Agriculture Institute of the Commons (CAIC): https://cellagri.org/en/about-us Japan Association for Cellular Agriculture (JACA): https://jaca.jp/en/ Upside Foods: https://upsidefoods.com/ Vow: https://www.eatvow.com/ Impossible Foods: https://impossiblefoods.com/ Fast Company: "Inside the stunning collapse of Believer Meats": https://www.fastcompany.com/91462102/believer-meats-stunning-collapse-600-million-cooling-cultured-meat-industry AG Funder News: "FDA clears Wildtype's cell-cultivated salmon": https://agfundernews.com/fda-clears-wildtypes-cell-cultivated-salmon-for-us-debut Food Navigator: Parima gets green light for cultivated duck: https://www.foodnavigator.com/Article/2026/04/15/parima-gets-regulatory-approval-for-cultivated-foie-gras/ Protein Production: "Japan publishes first draft safety guidelines for cultivated meat…": https://www.proteinproductiontechnology.com/post/japan-publishes-first-draft-safety-guidelines-for-cultivated-meat-as-regulatory-debate-advances Stateline: "Texas bans lab-grown meat": https://stateline.org/2025/06/30/texas-becomes-seventh-state-to-ban-lab-grown-meat/ TODAY: "Japan's Coca-Cola Plus has an unexpected ingredient": https://www.today.com/food/japan-s-coca-cola-plus-has-unexpected-ingredient-t121047 Timestamps: 0:00 Why founders should visit Japan 1:48 Intro of cultivated meat pioneer, Dr. Yuki Hanyu 3:19 Why don't consumers want lab-grown meat? 10:05 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 10:26 DIY meat manuals at comic conventions 15:37 Flavors that don't exist in nature 19:35 The Wagyu Hot Dog 21:38 MongoDB - AI-assisted and agentic coding is helping you build faster than ever. Start building at https://MongoDB.com/ai 24:23 Why chicken nuggets are the hardest problem 28:28 Beachhead markets, waypoints, and surviving early 30:25 Agree.com - Stop chasing invoices and automate your entire contract-to-cash stack. Go to https://agree.com and tell them Jason sent you to get 50% off for life! 35:57 Q&A: Commercializing an open source project 37:56 Q&A: Growing protein in space 40:07 Should this be called "meat"?   Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

In early 2023, Keith Peiris's AI-powered presentation startup Tome was growing quickly. It had become the fastest productivity tool to reach 1 million users, Forbes reported at the time, a number that eventually climbed to 25 million. He raised $80 million from top Silicon Valley investors like Lightspeed Venture Partners, Coatue, Greylock and billionaire Reid Hoffman. But by late 2024, Peiris realized he was building the wrong company.  It turned out that most people didn't want to pay for its tools, which generated beautiful slides within minutes. Tome's users, mainly students and small business owners, were largely on free plans or paying $10 monthly subscriptions—not nearly enough to sustain the business. And the startup couldn't quite crack the market for professionals like marketers and salespeople because it wasn't connected to their data and did not have the context needed to make good presentations. Users were still growing, but the company's annual revenue plateaued at around just $3 million.  “Being frank about Tome, our technology thesis and our cultural thesis was very immature,” Peiris admits now. By Rashi Shrivastava, Forbes Staff Learn more about your ad choices. Visit megaphone.fm/adchoices

In this recent episode of Possible, Reid Hoffman sits down with Microsoft CEO Satya Nadella fresh off Microsoft Build 2026. The conversation goes wide: how AI is reshaping work, business, and society—and why the transformation sweeping through software development today is only a preview of what's coming for all knowledge work. Satya makes the case that human capital and "token capital" are now deeply intertwined, that companies—not just countries—must build their own AI capabilities, and that the organizations best positioned to thrive are those that can leverage their unique expertise inside intelligent systems. Reid and Satya also explore Microsoft's enterprise AI vision, Reid's work with Manas on AI-powered scientific discovery, lessons from past technological revolutions, and why demonstrating real, tangible benefits may be the most important thing the industry can do to earn—and keep—the public's trust.You can catch and subscribe to more Possible here: https://www.possible.fm/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: PayPal Open https://paypalopen.com DigitalOcean https://do.co/twist Rippling https://Rippling.ai/twist   Today's show: *For three decades now, we've been told that breakthroughs in quantum computing are right around the corner. So why hasn't anything materialized? On TWiST in Tokyo, Jason sits down with Yaqumo CEO Kazuhiro Nakashoji and discusses what needed to change (like better algorithms and hardware), and why we may finally be nearing quantum's big moment. Find out why quantum machines are so error-prone, explore the unusual international quantum supply chain, and get a heads-up about the cryptography reckoning coming for your Bitcoin. Guest Kazuhiro Nakashoji on X: https://x.com/KNakashoji Yaqumo Inc.: https://yaqumo.com/en/ Relevant Links JETRO (Japan External Trade Organization): https://www.jetro.go.jp/en/ Institute for Molecular Science: https://www.ims.ac.jp/en/ Quantum Insider: Yaqumo Quantum Photonics Agreement: https://thequantuminsider.com/2026/06/04/yaqumo-nkt-photonics-and-hamamatsu-photonics-sign-quantum-photonics-agreement/ Quantonation investment announcement: https://quantumcomputingreport.com/quantonation-selects-neutral-atom-hardware-developer-yaqumo-for-first-japanese-investment/ NIST: What is Post-Quantum Cryptography? https://www.nist.gov/cybersecurity-and-privacy/what-post-quantum-cryptography Timestamps: 0:00 Intro / Founder University Tokyo 2:20 Guest intro: Kazu of Yakumo 3:20 What is a qubit? 8:34 Why quantum computers are so fragile 8:45 PayPal - Built for payments, growth, and agentic. Paypal Open, built for all business. Visit https://paypalopen.com to get started 13:36 Spinning IP out of the university lab 18:42 DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50%. 28:01 Building the "Toyota of Quantum" 29:38 Rippling - Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 31:25 AI for quantum, and quantum for AI 38:35 Harvest Now, Decrypt Later 41:41 Q&A: Yaqumo's business model 43:22 Q&A: Yaqumo's business model Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

The Secret Court Case That Could Destroy Super PACs ForeverSUPPORT MY WORK: Buy a paid subscription to my newsletter at https://www.usermag.co   Support my work on Patreon: http://patreon.com/taylorlorenz      You've been told that Citizens United created Super PACs… but that's not the full story. In this episode of Free Speech Friday, Harvard Law Professor Lawrence Lessig reveals the obscure lower court ruling (SpeechNow v. FEC) that actually unleashed unlimited billionaire money into American elections, and the groundbreaking legal strategy that could end Super PACs by 2028 WITHOUT overturning Citizens United.Backed by an unlikely coalition including Mark Cuban and Reid Hoffman, Lessig and his group Equal Citizens helped Maine voters pass a historic ballot initiative banning Super PAC contributions. Now the case is headed to the First Circuit Court of Appeals on July 29, with famed Supreme Court litigator Neal Katyal arguing that nothing in the Constitution protects billionaires' "right" to buy elections. If the appeal succeeds, this case could reach the Supreme Court by 2027 and revive existing federal limits on campaign contributions nationwide.We break down: ▶ Why SpeechNow v. FEC — not Citizens United — created the Super PAC system ▶ How the Menendez bribery indictment exposed the "no quid pro quo" myth ▶ The originalist argument designed to win over conservative justices ▶ Billionaire outside spending's explosion from 0.3% to 19% of election money ▶ The AI Super PAC trying to block Congress from regulating artificial intelligence ▶ Why an Article V constitutional convention may be the backup plan ▶ What happens if the First Circuit rules on July 29, and the road to SCOTUSIf you care about money in politics, campaign finance reform, and getting billionaire money out of elections, this is the most important legal fight you've never heard of.

Jim Collins is the author of some of the most important business books of all time, like Good to Great and Built to Last. For his latest project, instead of profiling iconic companies, he zoomed in on extraordinary individuals we can learn from. He joined host Jeff Berman to reveal how icons like Grace Hopper and John Glenn illustrate lessons on how to navigate the cliffs and fog of life. Find out more about the book: jimcollins.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Sentry https://sentry.io/twist Agree https://agree.com Northwest Registered Agent https://northwestregisteredagent.com/twist   Today's show: French ex-martial artist Bilal Kharouni is building his longevity startup from Okinawa, one of the world's "blue zones." (These are regions with the most people living long, healthy lives.) In this TWiST taping from Founder University in Tokyo, Jason investigates why a $200K raise in Japan can out-build a $2M raise in San Francisco, and why the best moat for biological AI isn't the model; it's the data no one else has. Plus a tactical and practical discussion of product market fit, why Ekei killed a growing side business to maintain focus, Japan's fast-track for regenerative medicine, and hitting the upper limits for consumer longevity gadgets. Plus a live Q&A with Founder U attendees. Guest Bilal Kharouni on LinkedIn: https://www.linkedin.com/in/bilal-kharouni/ Ekei Labs: https://www.ekeilabs.com/ Relevant Links Okinawa Institute of Science and Tech (OIST): ****https://www.oist.jp/ Life Biosciences: https://www.lifebiosciences.com/ NewLimit: https://www.newlimit.com/ Centivax: https://www.centivax.com/ Medical Daily: "First Human Trial to Reverse Aging Gets FDA Clearance": https://www.medicaldaily.com/first-human-trial-reverse-aging-just-got-fda-clearance-what-epigenetic-reprogramming-actually-476076 Tim Friede snake venom article from Science: https://www.science.org/content/article/he-injected-himself-venom-decades-can-his-antibodies-help-snakebite-victims Micro1: https://www.micro1.ai/ Whoop: https://www.whoop.com/ Station F Paris startup campus: https://stationf.co/ Japan Times: "PM Takaichi sleeps only 2-4 hours a night": https://www.japantimes.co.jp/news/2025/11/14/japan/politics/takaichi-sleep-overwork/ FDLI: "Japan's Regenerative Medicine Regulatory Pathways": https://www.fdli.org/2019/02/global-focus-japans-regenerative-medicine-regulatory-pathways-encouraging-innovation-and-patient-access/ FDA: "Right to Try": https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/right-try STAT News: "Are Blue Zones Real?": https://www.statnews.com/2026/05/04/are-blue-zones-real-new-scrutiny-longevity-hot-spots/ Timestamps: 0:00 Founder University is back in Japan! 4:05 What Ekei Labs does 5:13 Why Japan is a longevity hub 8:52 The AI biological moat 10:05 Sentry - Your team should be focused on shipping features — not chasing down bugs. New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 15:58 Right to try and the ethics of experimental therapies 22:30 Agree.com - Stop chasing invoices and automate your entire contract-to-cash stack. Go to https://agree.com and tell them Jason sent you to get 50% off for life! 24:49 Japan's fast-track regenerative medicine law 26:03 Raising in Japan vs. the US 31:32 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 40:44 Why Ekei killed a profitable service to focus 47:11 Have Blue Zones been debunked? 48:56 How socialization may extend lifespan 51:07 Founder Q&A: Booked vs. forecast revenue 55:42 Amazon's "bar raiser" framework 1:03:31 Social robots and loneliness 1:04:29 Jason on health and hustle culture   Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Social media strategist Will Weinbach joins Reid Hoffman and Parth Patil to explain how AI agents are reshaping content, distribution, and what a single creator can build. Will had never written a line of code before Parth handed him the tools to start. He traces his path from using ChatGPT to write essays, to vibe coding his own software, to running autonomous remote agents like OpenClaw and Hermes—systems that accumulate skills and memory and improve themselves on the fly. Not knowing how anything works under the hood, he argues, is exactly what lets him experiment without fear of what he might break. He walks through the fully autonomous social workflow he built, an agent that pulls, edits, captions, schedules, and posts content across every platform, then reads the analytics and A/B tests itself toward a goal. He also recounts the night his agent went rogue and posted four times at 4 a.m., and the experiment where he put an agent inside his TV just to see if it would work. Along the way, Will and Reid dig into what younger creators understand about attention that older marketing teams miss, and what happens to the resume when the real skill becomes knowing how to use AI. For Will, the edge isn't expertise. It's a willingness to try.

Few companies have a better real-time read on the American economy than Delta, and few CEOs are more willing to say what they actually think. Ed Bastian returns to Rapid Response to share what Delta's booking data is telling him that the headlines aren't, why he's not convinced by AI until it moves his top line, and how he decided to yank congressional travel perks during the government shutdown. He also explains what it takes to stay optimistic when fuel costs are spiking, the Strait of Hormuz is in the news, and the world keeps finding new ways to be unpredictable.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Superhuman https://superhuman.com YSecurity https://YSecurity.io/TWIST Today's show: *Cybersecurity has long focused on cleaning up a system AFTER a breach but Ent founder Brandon Dixon says that's backwards. He just raised a $100M seed round to put an AI agent on everyone's company laptops that catches the risky clicks, leaked files, or rogue agents BEFORE they wreck havoc. PLUS Clawra creator David Im return swith his new project, Sume's Avatar, a multi-model orchestration layer that generates 60-second UGC videos from a single prompt… and gets it right on the first try, rather than falling back on trial and error. Guests: Brandon Dixon on LinkedIn: https://www.linkedin.com/in/brandonsdixon/ Ent: ****https://ent.ai/ David Im on X: https://x.com/davidim Sume: https://www.sume.com/ Relevant Links: WSJ: "Cyber Security Startup Ent Raises $100 Million in Seed Funding": https://www.wsj.com/pro/cybersecurity/cyber-startup-ent-raises-100-million-in-seed-funding-a3e9b6c6 Microsoft Security Copilot: https://www.microsoft.com/en-us/security/business/ai-machine-learning/microsoft-security-copilot Engadget: "Meta 'pausing' employee tracking program…": https://www.engadget.com/2199458/meta-is-pausing-employee-tracking-program-after-it-let-the-whole-company-see-sensitive-data/ Seedance 2.0: https://seedance2.ai/ Timestamps: 0:00 Intro: Why AI + cybersecurity is the hot combo right now 2:29 How INT stops breaches before they happen 4:56 AI is giving non-technical employees dangerous new powers 10:26 Vanta - Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. Get $1,000 off for a limited time at https://www.vanta.com/twist 13:54 Why on-device AI beats cloud-based security 20:08 Superhuman - Get AI that works where you work. Unlock your Superhuman potential at https://superhuman.com 25:18 INT's business model and go-to-market 30:26 YSecurity - The on-demand security team for startups. Need enterprise-grade security without hiring a $400k CISO? YSecurity gives you 40+ expert engineers, matched to exactly what you need, by the hour, with your first six hours completely free. Go to https://YSecurity.io/TWIST 34:18 David M. of Sumi Labs: one-shotting AI video 36:10 Live demo: Sumi's video orchestration API 40:05 Consistent faces, 60-second videos, and who's buying Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

The dawn of surgery bots + buy a home for $250 (w/ Andromeda & Mogul) | E2313 This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist CLA https://claconnect.com/withyou MongoDB https://MongoDB.com/ai Today's show: *Andromeda Surgical is building the autonomy layer that could one day allow robots to perform surgery. Rather than building their own intricate, complex hardware, Andromeda uses off-the-shelf arms from a German manufacturer, and focuses on the software that will allow doctors to operate it from an iPad. Plus Mogul co-founder and CEO Alex Blackwood shows Jason how his platform lets anyone buy fractional shares of rental homes for as little as $250, earning monthly dividends, appreciation, and tax benefits without the headache of being someone's landlord. It's a founder double feature on a brand new TWiST. Guests: Nick Damiano on X: https://x.com/nickdamian0 Andromeda Surgical: https://www.andromedasurgical.com/ Alex Blackwood on X: https://x.com/blackwoodtweets Mogul: https://www.mogul.club/ Relevant Links: KUKA: https://www.kuka.com/ Intuitive Surgical (and Da Vinci 5): https://www.intuitive.com/en-us Neuralink: https://neuralink.com/ Padsplit: https://www.padsplit.com/ AngelList: https://www.angellist.com/ The Syndicate: https://thesyndicate.com/ Timestamps: 0:00 The iPad controlled surgery bot 5:46 Building "Google Maps for the body" 10:10 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 14:28 What is a "sous surgeon" 20:46 CLA - Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at https://www.claconnect.com/withyou 24:30 The Neuralink connection 29:40 Understanding Mogul's business model 31:01 MongoDB - AI-assisted and agentic coding is helping you build faster than ever. Start building at https://MongoDB.com/ai 33:32 So who manages the homes? 36:50 Dividends vs. Appreciation 44:57 How Mogul picks markets Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

The news of Texas covered today includes:Our Lone Star story of the day: There is dangerous cultural and media double standard regarding law enforcement and illegal immigration.  Texas media and the Democratic Party reflexively victimize illegal aliens while indicting American citizens and law enforcement – with little to no evidence for either action. U.S. Attorney Aaron Reitz details what it appears, based on real evidence, happened in the ICE shooting in Houston.Our Lone Star story of the day is sponsored by Allied Compliance Services providing the best service in DOT, business and personal drug and alcohol testing since 1995.Governor Abbott appoints Robert Howden as the 116th Texas Secretary of State.Texas Job Market Grows by More Than 177,000 Positions Over the Year. It's another month of record employment in the Lone Star State.Oil and gas rig count rises in Texas.Starship/Superheavy launch aborted at T-0; launch scrubbed. Possible retry next week.More hypocrisy from Little Jimmy “The Creep” Talarico: Leftist billionaire Reid Hoffman gives $10 million to pro-Talarico super PAC.Texas Tech throws aside history for a renaming of Jones Stadium – it's now Galaxy Stadium.Listen on the radio, or station stream, at 5pm Central. Click for our radio and streaming affiliates. www.PrattonTexas.com

Therapist Esther Perel wants us all to build stronger relationships at work. Her coveted advice is the centerpiece of her books, TED talks and podcast “Where Should We Begin?” During the pandemic, she launched a conversational card game. In 2025, she joined host Jeff Berman to talk about why she released another edition, Where Should We Begin? At Work, designed specifically for coworkers. They also go deep on why stronger relational intelligence is essential for businesses, how AI is rewiring our brains, and more.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Commercial director, AI filmmaker, and USC professor Ben Hansford joins Reid Hoffman and Parth Patil to explain how AI is reshaping Hollywood, film production, VFX, and comics. Ben has been experimenting with generative AI since before DALL-E and Midjourney went mainstream, using the earliest tools to sharpen commercial treatments, win jobs, and teach one of the country's first AI film courses. He traces Hollywood's arc from student protests and industry resistance to a scramble for answers, as shrinking budgets and shifting audiences push creators toward new workflows. He also recounts how a 30-minute AI VFX test reset his sense of what a director can prototype, and why he's building BloqBloq around a stark creative bottleneck: as he puts it, there are more NBA players than professional comic book illustrators. He maps the "iceberg" of creation, from databases and security to publishing and iteration, and explains why turning an idea into a finished product takes more than a prompt. For Ben, AI isn't just a tool. It's a crew. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

In the last year, Canva redefined itself from the ground up. Co-founder and Chief Product Officer Cameron Adams joins Rapid Response live from the Cannes Lions festival to explain why the so-called SaaSpocalypse never kept him up at night, how Canva shifted from a design company to an AI company without losing what made it great, and why being only 1% of the way there is actually the most exciting place to be. Adams also shares the specific steps anyone can take to get real impact from AI tools rather than just falling down the rabbit hole, and makes the case that in a world of commoditized models, your organization's unfair advantage is the only thing that matters.Eager for more of Cam? Take a moment to listen and download his own podcast, Prompted!Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Quo https://quo.com/TWiST PayPal Open https://paypalopen.com Northwest Registered Agent https://northwestregisteredagent.com/twist Today's show: *Jason spent $11 building out PodMeme, an AI tool that tracks down the best segments from top podcasts about a specific topic, then stitches them together into a single stream. His post laying out how he did it, featuring a simple screenshot of the product, got all the way to 1.1M views in just a few days. It's a simple fact: builders love to see what other people are building, and growing your new project "in public," sharing your journey on social media, is a great way to develop buzz around your product before it even exists. Today's guest Thibault "Tibo" Louis-Lucas walks us through how he grew products like Tweet Hunter and Taplio on his social media account, using social media buzz and a focus on tools for creators to very quickly expand to over $1M ARR. PLUS why Apple would only sue OpenAI if they knew they had them dead to rights… why Uber and Waymo are fighting over DC robotaxis… Jason's response to the public backlash against surveillance startup Flock Safety… and the guys remember iconic New Zealand actor Sam Neill. Guest: Tibo Louis-Lucas on X: https://x.com/tibo_maker Revid.ai: https://www.revid.ai/ Tweet Hunter: https://tweethunter.io/ Taplio: https://taplio.com/ Relevant Links: Lemlist: https://www.lemlist.com/ GRIN influencer marketing: https://grin.co/ TechCrunch: "Apple Sues OpenAI": https://techcrunch.com/2026/07/10/apple-sues-openai-over-alleged-trade-secret-theft/ We Must Act Now statement: https://www.wemustactnow.ai/ TechCrunch: "Uber's Robotaxi Lobbying Effort": https://techcrunch.com/2026/07/13/ubers-robotaxi-lobbying-effort-has-put-it-on-a-collision-course-with-waymo/ DC Autonomous Vehicle Deployment Authorization Amendment of 2026: https://www.billtrack50.com/billdetail/2003462 DoorDash: Meet Dot: https://about.doordash.com/en-us/dot Flock Safety: https://www.flocksafety.com/ DeFlock: https://deflock.org/ Gigazine: Flock accuses Deflock of being a "terrorist org": https://gigazine.net/gsc_news/en/20260209-flock-ceo-deflock/#gsc.tab=0 Unifi AI Security Systems: https://ui.com/physical-security Jason's PodMeme post: https://x.com/Jason/status/2076231055443440105 Jason responds to Justine Bateman: https://x.com/Jason/status/2076326740050206959 NYT Sam Neill obituary: https://www.nytimes.com/2026/07/13/movies/sam-neill-dead.html "Possession" trailer: https://www.youtube.com/watch?v=aLXW-oVbTxE FanEdit: https://fanedit.org/forums/news-publisher/ "Manhunter" trailer: https://www.youtube.com/watch?v=cLqHlg2fAnE HBO "The Man Will Burn" trailer: https://www.youtube.com/watch?v=kRhUYPtp6Ao Timestamps: 0:00 There's no air conditioning in Paris 7:27 Tibo Maker's "ship 1 product a week" challenge 9:24 The power of building products in public 10:59 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST 12:04 Excitement for JCal's "PodMeme" set-up 15:40 Compounding an audience and enlisting influencers 19:13 Your follower count is not important any more 20:59 PayPal - Built for payments, growth, and agentic. Paypal Open, built for all business. Visit https://paypalopen.com to get started 22:28 How Tibo got banned on LinkedIn twice 28:48 Apple sues OpenAI 30:59 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 38:44 How OpenAI should have handled the New York Times 45:10 DC's new robotaxi bill 52:06 Managing the AV and delivery-bot transition 53:23 Economists warn of AI job displacement 1:07:00 How Jason would fix Flock's messaging 1:17:26 Remembering Sam Neill 1:23:05 Lon's Dream AI edit 1:26:35 HBO's Burning Man docuseries   Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com  

Tractors are smarter than you think. John Deere, the nearly 200-year-old company, is combining sensors, data, and machine learning in highly advanced vehicles and software to reinvent how the world grows food. On this Pioneers of AI episode, John Deere CTO Jahmy Hindman breaks down how AI is making farms faster, smarter, and more sustainable. Plus he shares his vision for a fully autonomous farm.Learn more about Pioneers of AI: http://pioneersof.ai/Follow Pioneers of AI on all channels: https://linktr.ee/pioneersofaiSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this recent episode of Possible, Reid Hoffman sits down with Microsoft CEO Satya Nadella fresh off Microsoft Build 2026. The conversation goes wide: how AI is reshaping work, business, and society—and why the transformation sweeping through software development today is only a preview of what's coming for all knowledge work. Satya makes the case that human capital and "token capital" are now deeply intertwined, that companies—not just countries—must build their own AI capabilities, and that the organizations best positioned to thrive are those that can leverage their unique expertise inside intelligent systems. Reid and Satya also explore Microsoft's enterprise AI vision, Reid's work with Manas on AI-powered scientific discovery, lessons from past technological revolutions, and why demonstrating real, tangible benefits may be the most important thing the industry can do to earn—and keep—the public's trust.You can catch and subscribe to more Possible here: https://www.possible.fm/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: NetSuite https://NetSuite.ai/TWIST Squarespace https://squarespace.com/twist YSecurity https://YSecurity.io/TWIST Today's show: *America posted 400,000 farm jobs last year, and fewer than 1% got a single domestic applicant. Danny Bernstein of Reservoir believes it's time to start automating this backbreaking labor, like picking stone fruit in 110°F temperatures. So he built the world's first on-farm robotics incubator on 40 acres of California farmland. Here's why he argues that automating farms isn't just a new opportunity, it's a national security issue. PLUS Jason responded to Gal Shir's viral "AI beat me at design" tweet, got into a kerfuffle with Figma CEO Dylan Field, and wound up making a brand new J-Trade. AND we're talking about the Dept. of Education's new "do no harm" policy, the Brown University AI cheating chart that's blowing up social media, and Lon has fresh streaming recommendations in an all-new Off Duty. Guest: Danny Bernstein on X: https://x.com/bernsteind Reservoir Farms: https://reservoir.co/ Reservoir VC: https://reservoir.vc/ Relevant Links: Bonsai Robotics: https://bonsairobotics.ai/ Root AI acquired by AppHarvest: https://www.therobotreport.com/root-ai-acquired-by-appharvest-for-60m/ John Deere: https://www.deere.com/en-us/ Western Growers Association: https://www.wga.com/ Tanimura & Antle: https://www.taproduce.com/ Naturipe Berry Growers: https://www.naturipefarms.com/ Driscoll's: https://www.driscolls.com/ Taylor Farms: https://www.taylorfarms.com/ The Wonderful Company: https://www.wonderful.com/ Capital Factory: https://www.capitalfactory.com/ Gal Shir "quitting design" post: https://x.com/galshirart/status/2074854464729629060 Dylan Field response to Gal Shir: https://x.com/zoink/status/2075290218660298807 JCal response to Field and "J-Trade": https://x.com/Jason/status/2075481565115654305 Figma: https://www.figma.com/ Dept. of Education: "Do No Harm" policy announcement: https://www.ed.gov/about/news/press-release/us-department-of-education-issues-final-rule-hold-all-colleges-and-universities-accountable-low-earning-programs NPR coverage on Dept. of Education earnings test: https://www.npr.org/2026/06/30/nx-s1-5835631/turner-camhi-do-no-harm-college-loans Paul Graham "cheating chart" post: https://x.com/paulg/status/2075031014628311236 Off Duty Recommendations: "Lioness" on Paramount+: https://www.youtube.com/watch?v=jNRQ0PR4a8U "Mayor of Kingstown" on Paramount+: https://www.youtube.com/watch?v=VkQzvwxOp0s "Human Vapor" on Netflix: https://www.youtube.com/watch?v=7xe6dRKVAb8 "Sugar" on Apple TV+: https://www.youtube.com/watch?v=twvPGxuEOEA "Wind River" (now on Netflix): https://www.youtube.com/watch?v=CZgN0dpFoaE "Not Fade Away" by Peter Barton & Laurence Shames: https://www.amazon.com/Not-Fade-Away-Short-Lived/dp/1579546889 Timestamps: 0:00 Jason's ongoing World Tour 1:43 Danny Bernstein joins live from Reservoir Farms 3:38 What is "specialty crop agriculture" 5:15 Why strawberries are the "white whale" of AgTech 6:55 The labor crisis in farming 9:20 Why AgTech never scaled 9:51 NetSuite - For the first time, you can try NetSuite Next for free. If your revenues are at least in the seven figures, go to https://NetSuite.ai/TWIST 10:51 Inside Reservoir's business model 17:44 Agriculture as national security 20:09 Squarespace - Turn your idea into a beautiful website! Go to https://www.squarespace.com/twist for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain. 22:15 Did AI beat a designer at design? 30:56 YSecurity - The on-demand security team for startups. Need enterprise-grade security without hiring a $400k CISO? YSecurity gives you 40+ expert engineers, matched to exactly what you need, by the hour, with your first six hours completely free. Go to https://YSecurity.io/TWIST 37:23 The "do no harm" college earnings test 43:27 Brown University students cheated on their midterms 52:22 Lon's streaming recommendations 59:46 Jason's new snake grabber   Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Telling a clear story about your product is an essential entrepreneurial skill. Chef Marcus Samuelsson is an expert at this in his beloved restaurants (Hav & Mar and Red Rooster) and through his broader entrepreneurial efforts.Samuelsson joined host Reid Hoffman in 2024 to share how embracing a diversity of stories has been an essential ingredient to his businesses.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: Digital Ocean - do.co/twist Agree.com - agree.com Every.io - every.io.   Today's show: How many startups matter in tech? Fewer than you think. That's why venture capitalists are tripping over themselves to get onto their cap tables, no matter the cost. Why? Footwork's Nikhil Basu Trivedi argues that the Valley has never been more "power-law-pilled" than it is today. Basu Trivedi joined Cendana Capital's Michael Kim and TWiST's Alex Wilhelm to go deep on secondary markets, the state of startup M&A, why the SaaSpocalypse may be temporary, and what could trigger a retrenchment of the AI trade. It's Wednesday, so it's time for our venture capital roundtable to go deep on how VCs are investing today, and where on the horizon they have their eyes fixed! Guest links: Nikhil Basu Trivedi https://x.com/nbt Footwork https://www.footwork.vc/ Michael Kim https://x.com/MKRocks Cendana Capital https://www.cendanacapital.com/ Show links: The USVC-Anduril blowup https://x.com/ankurnagpal/status/2072701195714531398 Kline Hill Cendana Partners https://www.secondariesinvestor.com/kline-hill-and-cendana-raise-400m-for-second-vc-secondaries-fund/ GPTZero's exit https://gptzero.me/news/preserving-whats-human/ Salesforce buys Fin https://www.salesforce.com/news/press-releases/2026/06/15/salesforce-signs-definitive-agreement-to-acquire-fin/ Vercel buys Better Auth https://vercel.com/blog/vercel-acquires-better-auth Figma buys Bud https://techcrunch.com/2026/07/07/figma-acquires-team-behind-a-vibe-coding-app/ Protoge https://withprotege.ai/ Windborne https://windbornesystems.com/ Etched https://www.etched.com/ Lovable's reported raise https://sifted.eu/articles/lovable-300m-13-2bn-valuation Josh Browder https://x.com/Joshuabrowder   Timestamps: 0:00 Introduction: Nikhil Basu Trivedi (Footwork) & Michael Kim (Cendana Capital) 1:59 The Anduril vs. USVC secondary market blowup 4:08 Why Silicon Valley is 'power-law-pilled' 8:23 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 9:37 Information asymmetry in the secondary markets 9:45 Every.io — For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 15:02 Is SPV fraud smoke or fire? 16:32 Superhuman acquires GPTZero 19:54 Agree.com - Stop chasing invoices and automate your entire contract-to-cash stack. Go to https://agree.com and tell them Jason sent you to get 50% off for life! 21:10 The M&A wave 27:19 The SaaSpocalypse debate 29:59 DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50%. 30:44 Data's moment in the energy → compute → data loop 35:01 Where will AI value accrue? 40:04 What could cause an AI correction? 42:17 Why some companies are "too big to miss" 46:23 China's possible open-weight model ban 53:28 Young founders: Etched, Thiel Fellows, Z Fellows, Neo 55:33 Portfolio spotlight: WindBorne's weather balloons and data moat 58:47 Michael's favorite fund manager: Josh Browder Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp   Follow Lon: X: https://x.com/lons   Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm   Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis   Check out all our partner offers: https://partners.launch.co/   Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland   Check out Jason's suite of newsletters: https://substack.com/@calacanis   Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Gap was never uncool. It just disappeared. CEO Richard Dickson joins Rapid Response to explain how he's bringing it back, using the same pop culture playbook he used to resurrect Barbie at Mattel. He breaks down why he tracks "brand love" metrics on a dashboard hourly, why Sydney Sweeney's viral jeans ad was actually good news for the whole industry, and why the biggest risk a brand can take is playing it safe. Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“I'm a proud American. I became a citizen in 2021. I feel at home here both in America and actually, in a way I actually have never felt before. I feel like this is where I'm meant to be, and I couldn't be more honoured that people now are putting their faith in me to turn the state around.”Nick Robinson speaks to Steve Hilton, the British-born Republican candidate for governor of California in November's US midterm elections.Once a senior adviser to former UK prime minister David Cameron, Hilton left British politics to build a new life in America. Now endorsed by President Donald Trump, he explains why he believes the Republican Party best represents what he calls “positive populism”.Hilton reflects on his upbringing as the son of Hungarian refugees, the opportunities he says transformed his life, and why he feels a stronger sense of belonging in America than he ever did in Britain.The Interview brings you conversations with people shaping our world, from all over the world. The best interviews from the BBC, including episodes with former US Secretary of State John Kerry and LinkedIn co-founder Reid Hoffman.You can listen on the BBC World Service on Mondays, Wednesdays and Fridays at 0800 GMT. Or you can listen to The Interview as a podcast, out three times a week on BBC Sounds or wherever you get your podcasts.Presenter: Nick Robinson Producer: Osman Iqbal Editor: Damon Rose(Image: Steve Hilton. Credit: Reuters)

This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist Vanta https://www.vanta.com/twist Sentry https://sentry.io/twist Today's show: *There are $100 trillion in global assets sitting on top of what Hanover Park co-founder/CEO Chris Hladczuk calls "human duct tape": armies of accountants in offices patching together work from various legacy tools (QuickBooks, Excel) that are holding funds' own data hostage. Can all of this be replaced with AI? Find out how their startup went from overseeing $1B to $20B in assets in just 15 months. PLUS, we flash back to March 2020, when Jason and Figma co-founder/CEO Dylan Field broke down the design tool's initial go-to-market strategy, made some WILDLY inaccurate COVID predictions, and considered anxiety about "SaaS burnout" years before the category went full apocalyptic. Guests: Chris Hladczuk on X: https://x.com/chrishlad Hanover Park: https://www.hanoverpark.com/ Dylan Field: https://x.com/zoink Figma: https://www.figma.com/ Relevant Links: Turner Novak on X: https://x.com/TurnerNovak Banana Capital: https://www.bananacapital.vc/ Emergence Capital: https://www.emcap.com/ Lux Capital: https://www.luxcapital.com/ Susa Ventures: https://susaventures.com/ Bill.com: https://www.bill.com/ METR: https://metr.org/ Granola AI note taker: https://www.granola.ai/ Vanta: https://www.vanta.com/ Foo Camp on YouTube: https://www.youtube.com/c/foocamp TechCrunch Mahalo coverage: https://techcrunch.com/2014/01/27/inside-mobile-news-launch/ Timestamps: 0:00 Hanover Park & the fund admin problem 3:32 Why funds outsource instead of building 5:44 Why fund accounting is so complex 10:38 The "one-click migration" goal 10:48 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist 13:51 Context vs. intelligence gaps 16:11 No PMs, No Designers 20:46 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 23:18 This is a $100T opportunity 25:36 Flashback w/ Dylan Field of Figma 29:15 Sentry - Your team should be focused on shipping features — not chasing down bugs. New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 31:22 Pre-AI enterprise security worries 36:30 SaaS overload and SaaS burnout 37:30 The evolution of Figma pricing 42:38 The rise and fall of Mahalo dot com 51:38 The work-from-home revolution begins Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (0:00) PARTNER - AD BLURB (0:00) PARTNER - AD BLURB (0:00) PARTNER - AD BLURB Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason's suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Every startup pitch deck has a "why now" slide. Most of them are nonsense, barely considered, and only there to tick a box.But timing is more than a slide, it can make or break a company. It's the difference between pets.com and the trillion-dollar company selling the exact same idea a decade later.In this episode, Yaniv Bernstein sits down with Paul Orlando, who has built four startup accelerators supporting over 300 companies, including Hong Kong's first accelerator and a program in Rome run in partnership with the Vatican, and has taught entrepreneurship at USC for over a decade, where he also runs one of LA's largest startup incubators. Paul has spent years obsessing over a single question: why do some ideas succeed while near-identical ones fail years earlier? The answer became his book, ‘Why Now? How Good Timing Makes Great Products.'In this episode, you will:Learn Paul's framework of timing drivers, and the five that show up again and again: technology, social/behavioral change, regulation, installed base, and crisisWalk through the YouTube case study in detail to see how broadband penetration, digital camera adoption, and falling storage costs converged to make 2005 the right year, after the identical idea failed less than a decade earlierDiscover why first-mover advantage is much narrower than founders assume, and the two specific conditions (locking in customers, locking out competitors) required for it to actually workGet a framework for balancing founder agency against timing, because you can't will your way into good timing, but you also can't wait passively for the perfect moment to arriveTimestamps00:00 Coming Up...01:04 On Today's Show: Why Timing Matters01:44 Guest Intro: Paul Orlando02:42 Is 'Why Now' Predictable?05:40 Paul's Timing Drivers Framework08:44 Case Study: YouTube's Market Timing11:47 Business Model Shifts15:16 Case Study: Pets.com Unit Economics22:16 Case Study: AI Vibe Coding24:11 What Are 'Sleeping Beauty' Startups?27:46 Incorporating AI into Timing Drivers28:52 Collapse of Build Costs33:34 Case Study: Vera and Unit Economics of Voice35:15 False 'Why Now' Risks37:46 First Mover Reality40:33 Reid Hoffman on Blitzscaling41:49 Case Study: AT&T's Picturephone and Mobile Telephony46:31 Lessons on Failure and Agency54:09 Closing ThoughtsResources mentioned'Why Now?: How Good Timing Makes Great Products' by Paul Orlando: https://www.amazon.com/Why-Now-Timing-Makes-Products/dp/B0CYXSNMT3Paul's website, Startups Unplugged: https://startupsunplugged.comPaul on LinkedIn: https://www.linkedin.com/in/porlandoPaul on X/Twitter: https://twitter.com/porlandoThe PactHonor the Startup Podcast Pact! If you have listened to TSP and gotten value from it, please:Follow, rate, and review us in your listening appSecure your official TSP merchandise at https://shop.tsp.show/Follow us on YouTube for full video episodes: https://www.youtube.com/channel/UCNjm1MTdjysRRV07fSf0yGgGive us a public shout-out on LinkedIn or anywhere you have a social media followingKey linksThis episode of the Startup Podcast is sponsored by .tech domains. Forget weird prefixes and creative misspellings; the availability for .tech domains is simply way better than .com. For a clean name that highlights your tech credentials, get a .tech domain at your favorite registrar.The Startup Podcast website: https://www.tsp.show/episodes/Learn more about Chris and YanivWork 1:1 with Chris: http://chrissaad.com/advisory/Follow Chris on Linkedin: https://www.linkedin.com/in/chrissaad/Follow Yaniv on Linkedin: https://www.linkedin.com/in/ybernstein/Producer: Justin McArthur https://www.linkedin.com/in/justin-mcarthurAssistant Producer: Steph Hefferan https://www.linkedin.com/in/steph-heff/Intro Voice: Jeremiah Owyang https://web-strategist.com/

If you're an experienced leader, founder or consultant, there's a particular kind of quiet risk you might not be tracking. The world you built your career in is being rewritten, and the tools that used to belong to well-funded companies now sit on your laptop for free.This week I'm joined by Jay Samit, author of Disrupt You, Future Proofing You, and his latest book, The Second Act Advantage. Jay was in the room when Reid Hoffman launched LinkedIn, helped monetise Facebook, ran EMI through the Napster years, and has been a futurist for more than half a century. He is not a hype merchant. He is someone who has watched every major technology shift up close, and he thinks this one is different.Our conversation is a wake-up call, but not a doom scroll. It is about where the real opportunity sits for people who are already good at what they do, and how to move before the ground shifts under you.✳️ Why AI is not another industrial revolution. It is closer to fire, and this time it comes for knowledge workers first.✳️ The illusion of job security. The original Fortune 500 has lost 90% of its members, and the safety net you think you have is thinner than you realise.✳️ How ordinary people are building global businesses off the "crumbs" the trillion-dollar companies leave on the ground, using tools they never had to pay for.Jay's Amplifiers✳️ Speak to yourself in the mirror every morning. Two lines only: "Today can be better than yesterday. And I have the power to make it so." Your brain does not know you are talking to it. It just responds.✳️ Do not retire, in any sense of the word. Keep learning something that requires muscle memory, protect your purpose, and treat autophagy and sleep as seriously as you treat your calendar.✳️ Be unique on purpose. Everything else is already taken. Whatever you create, think or build is now being absorbed by a system that will outlast you. That is a legacy opportunity no previous generation has had.If this is your first time here, hit follow so the next episode finds you automatically. And if you already listen, thank you. It genuinely matters.Timestamps00:01 - Sponsor: Granola01:15 - Cold open with Jay01:59 - Welcome and why this episode matters03:02 - Introducing Jay Samit04:14 - Jay's story, from nerd to billionaire whisperer07:41 - Why this AI shift is different from every other one10:00 - Playing Pygmalion with a young millennial13:05 - The illusion of corporate security20:41 - AI as amplifier, not replacement23:05 - The difference between chasing AI and mastering it27:33 - Why most people freeze when it is time to reinvent35:19 - Vibe coding explained without the jargon39:45 - Competition is not the enemy you think it is41:28 - What actually drives Jay's decision to move on47:47 - Curiosity, effort, belief, and the right tools49:19 - Amplifier 1: The mirror trick and the Pygmalion effect53:06 - Amplifier 2: Longevity, purpose and the lazy nerd's guide57:21 - Amplifier 3: Be unique, because everything else is taken01:02:00 - Where to find Jay and the Second Act Society01:03:31 - Close and the Personal Brand Business Roadmap----Get your copy of my Personal Brand Business BlueprintIt's the FREE roadmap to starting, scaling or just fixing your expert business.www.amplifyme.agency/roadmap----Subscribe to my Youtube!! Follow on Instagram and Twitter @bobgentleJoin the Amplify Insiders Facebook Community : www.amplifyme.agency/insidersPlease take a second to rate this show in Apple Podcasts. ❤ It will mean a lot to me.Mentioned in this episode:Signature StudioGet started today - signtaturestudio.me

Mark Pincus is a serial tech entrepreneur and investor best known as the co-founder of Zynga. He joins host Reid Hoffman to reveal the insights at the center of his new book: Life at the Speed of Play. The godfather of mobile gaming talks with Hoffman about building products people love, learning fast from your mistakes, and handling screen time for his own kids. The book: https://www.lifeatthespeedofplay.com/Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by: CLA - www.claconnect.com/withyou Northwest Registered Agent - www.northwestregisteredagent.com/twist Agree.com - www.agree.com Today's show: Forget the triple-triple-double-double-double; the new bar for startups hoping to raise venture capital has reached the stratosphere, though our venture panel is worried that startups are focusing too much on today's problems that may not become companies tomorrow. During a lively VC roundtable, Cowboy's Aileen Lee, Floodgate's Mike Maples, and Lerer Hippeau's Ben Lerer joined Alex to dig into exiting pre-AI startups, rising valuations, token spend, why they are keeping their funds small, and whether the government just tripped OpenAI and Anthropic! Guest Links: Aileen Lee https://x.com/aileenlee Cowboy VC https://cowboy.vc Mike Maples https://x.com/m2jr Floodgate https://www.floodgate.com Bene Lerer https://www.linkedin.com/in/benjlerer Lere Hippeau https://www.lererhippeau.com Timestamps: 0:00 Aileen Lee, Mike Maples, and Ben Lerer join the show 5:13 Venture liquidity returns: what SpaceX/Stripe distributions mean for LPs 9:13 Bending Spoons prices IPO at $29/share, roughly $18.4B valuation 10:31 Agree.com - Stop chasing invoices and automate your entire contract-to-cash stack. Go to https://agree.com and tell them Jason sent you to get 50% off for life! 12:09 "Companies get bought, not sold" — Ben on taking first offers seriously 17:41 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 19:34 Mutiny's burn-the-boats AI pivot with Jaleh Rezaei 20:19 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist 22:15 Mike's KeepSafe story: the "rule of 70" and profit-first companies 25:12 The new growth bar: 5x, 4x replaces triple-triple-double-double 28:55 Fund size is your strategy: why Floodgate and Lerer Hippeau stay small 30:11 CLA - Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at https://www.claconnect.com/withyou 37:39 The $100M Series A: Starcloud, General Intuition, Scale Cognition, Scout AI 40:35 King-making rounds and why mega-seeds destroy optionality 54:11 Open-weight models: the GLM-5.2 moment and going model-agnostic 55:30 Why fine-tuning open models is a treadmill, with Cursor/Kimi as an example 1:03:28 Grading the Trump administration on Mythos and Fable 1:06:33 Rising anti-AI sentiment, the wealth gap, and lessons from social media 1:11:43 Raising kids in the post-intelligence era 1:12:35 Where to find the panel and what each firm is investing in Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason's suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

Every year at Cannes Lions, the advertising world takes stock of itself — what's working, what's not, and what it's pretending not to notice. Autodesk CMO Dara Treseder joins Rapid Response live from the festival to cut through the noise. She breaks down the industry's complicated relationship with AI, weighs in on the hottest and most overrated campaigns of the year including sharp takes on Nike, Adidas, and Starbucks, and explains why the path from CMO to CEO is suddenly the most interesting career move in business. Treseder also gets candid about the brand of Elon Musk post-IPO, what Autodesk's $350 million investment in the next generation of workers actually signals, and what separates a brand collaboration that breaks through from one that just breaks.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Plaudhttps://Plaud.ai/twistShopifyhttps://shopify.com/twistLinkedIn Jobshttps://LinkedIn.com/twistNorthwest Registered Agenthttps://northwestregisteredagent.com/twistToday's show:*It's another All Star Summer, as we welcome back some of our favorite guests from throughout “This Week in Startups” history.Chamath Palihapitiya's development platform 8090 just raised $135 million, and he's using it to go after a $4 trillion market: the software maintenance, migration, and middleware spending that's currently “pure waste” for enterprises.Find out why the All-In Podcast bestie says every company should use AI to build custom software the way that Google, Facebook, and Meta already do, then go inside Software Factory, the “system on a chip” organizational model, and why Chamath believes AI will allow every human on Earth to start their own company.Guest:Chamath on X: https://x.com/chamath8090: https://www.8090.ai/Learn With Me on Substack: https://chamath.substack.com/p/learn-with-meDrink With Me: https://www.drinkwithme.com/age-verify.htmlAll-In Podcast: https://allin.com/Social Capital: https://www.socialcapital.com/Relevant Links:8090 Series A announcement: https://x.com/chamath/status/2071571183665881515Salesforce Ventures: https://salesforceventures.com/Craft Ventures: https://www.craftventures.com/The Production Board: https://www.tpb.co/WNDR: https://www.wndr.vc/LAUNCH: https://www.launch.coCoatue Management: https://www.coatue.com/Jack Dorsey: “From Hierarchy to Intelligence”: https://block.xyz/inside/from-hierarchy-to-intelligenceThomas Keller's The French Laundry: https://thomaskeller.com/tfl/Timestamps:0:00 It's TWiST All-Star Summer!0:44 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:21 Chamath's origin story7:54 Tom Sawyer entrepreneurship11:29 Shopify - Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist16:25 The $5 trillion software market21:06 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist25:00 Building "a co-founder for every human"31:51 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist35:00 How product development lost its way45:00 Regulated industries are the beachhead50:00 Raising the $135M Series A55:00 8090's "System on a Chip" model1:04:44 What to tell your kids about AISubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Anthropic and OpenAI's plans to go public have set off waves of speculation about the ripple effects, and how they'll stack up to the SpaceX IPO. What's really driving the value of these companies? Does the timing of the IPOs matter? How might they impact the AI startup ecosystem?To process all this, Pioneers of AI phones a friend: Reid Hoffman. As co-founder of LinkedIn and Manas AI, a longtime Microsoft board member, investor in OpenAI and Anthropic, and so much more, Reid offers his take on the AI investing landscape. Rana and Reid break down the IPO headlines, sovereign wealth fund proposals for AI, and what's defensible in AI today. Learn more about Pioneers of AI: http://pioneersof.ai/Follow Pioneers of AI on all channels: https://linktr.ee/pioneersofaiSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Plaud - https://Plaud.ai/twistSentry - https://sentry.io/twistNorthwest Registered Agent-https://northwestregisteredagent.com/twistDigitalOcean - https://do.co/twistToday's show:F1 teams spend up to a third of their budgets on aerodynamics, often utilizing wind tunnels to simulate what happens on the track.But Lyall Davenport of SKN Systems created a sensor-embedded tape that sticks directly to race cars as they drive around the real world, generating 420M data points per hour. And it comes in at roughly 95% less cost than running a full simulator.Hear about how Lyall's background in racing helped him develop the concept, plans to expand from motorsports to drones and defense, and his experiences going through Jason's various programs.PLUS OpenAI's new models are so good, you can't use them. Why Apple's Vision Pro chief defected to OpenAI (and why their laptops and devices are getting more expensive). A look at the world's most annoying data center in Sterling, Virginia. And Jason remembers iconic and influential tech journalist Om Malik.Guest:Lyall Davenport: https://x.com/LyalldavenportSKN Systems: https://www.skn.systems/Timestamps:0:00 How SKN uses tape to generate aerodynamic data4:04 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!6:17 How SKN uses tape to generate aerodynamic data9:55 Sentry - Your team should be focused on shipping features — not chasing down bugs. New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST17:20 F1 teams are worth HOW MUCH?19:42 Northwest Registered Agent: Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist20:35 Future markets beyond motorsports30:03 DigitalOcean - Want to see what building on a true AI-native platform looks like? Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50%.32:45 GPT-5.6 is banned for now43:46 Vision Pro chief makes for the exit51:24 Apple raises their prices56:05 The data center you're allowed to hate1:06:04 Zuck's new prediction market app1:08:42 RIP Om Malik (1966-2026)1:19:50 Streaming and camera recommendations1:28:06 All about eFoilingSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Care.com is the digital marketplace that connects caregiving professionals with people who need help with kids, seniors, pets, and more. It's the market leader in an area where the need is constantly growing. Host Jeff Berman talks with CEO Brad Wilson about how companies can create more loyal employees by supporting caregiving, why the future of work needs to be flexible, how he's leading through transformational technology change at the company, and more.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Deel - deel.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistLinkedIn - linkedIn.com/twistToday's show:Jason sits down with Brynn Putnam, CEO and founder of Board, to learn more about her company's tabletop gaming console. The pair talks about how to raise capital for yet-to-launch hardware projects, the screen-time debate, and how Board is approaching building or buying IP for its family-friendly games. Next, Alex got Heremus's AJ Piplica on the horn to chat hypersonic, autonomous jets. The startup's technology bridges the gap between rockets and airplanes, and may represent the future of warfare, yes, but also fast freight!Guest Links:Brynn Putnam https://x.com/BrynnPutnamBoard https://board.fun/Board Series A announcement https://techcrunch.com/2026/06/02/board-the-new-game-startup-from-mirror-founder-brynn-putnam-raises-20m-has-already-sold-thousands/Mirror https://www.lululemonstudio.com/AJ Piplica https://x.com/AJ_PiplicaHeremus https://www.hermeus.com/Heremus Series C announcement https://www.prnewswire.com/news-releases/hermeus-reaches-1-billion-valuation-with-350-million-raise-to-build-todays-fastest-aircraft-for-the-american-warfighter-302735273.htmlTimestamps:0:00 Board's Brynn Putnam joins the show2:54 Board's proprietary AI software stack6:43 Why Board manufactures in Mexico (not China)9:21 LinkedIn: Thanks to our partners at LinkedIn! Post your job for free at https://linkedIn.com/twist then promote it to get access to LinkedIn Jobs' new AI assistant.9:42 How to raise a Seed round for hardware without a finished product15:26 Brynn's daughter and the mermaid example17:09 Can Board limit screen time fears?18:47 Northwest Registered Agent: Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist22:54 Selling the first 10,000 units28:38 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.29:42 Why Board is steering away from simple ports toward native IP experiences35:32 Hermeus's AJ Piplica joins the show35:32 What is Dark Horse?43:48 Commercial applications: Cargo, organs, flowers, and trans-Atlantic in 90 minutes47:47 Commercial applications: Cargo, organs, flowers, and trans-Atlantic in 90 minutes57:00 Dark Horse range and the "reusable first stage" analogy58:42 Dark Horse range and the "reusable first stage" analogy1:02:42 $350M Series C led by Khosla; total funding now exceeds $500M1:03:39 The SpaceX model: get customers to fund your R&D1:07:47 Closing: the American Dynamism pitchSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

David protein bars went from startup to one of the hottest consumer products in America in under two years. But the ride has been anything but smooth. Founder and CEO Peter Rahal joins Rapid Response to talk about building a breakout brand through lawsuits, a Jeffrey Epstein association, and the kind of social media heat most companies would run from. Rahal also revisits his $600 million sale of RXBar to Kellogg and what he learned about keeping your edge after a defining win.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Agree - https://agree.comQuo - https://quo.com/TWiSTSuperhuman - https://superhuman.comToday's show:In this double-header, Jason and Lon chat with Louis Phillips, founder of the gamified running app INTVL, which turns a quick job around the block into a worldwide turf war competition. Find out how he grew the app to over 1 million downloads without any paid ads, just making videos from his home office.PLUS Alex sits down with Alice Zhang, CEO of Verge Labs, which pivoted from making drugs to building the AI infrastructure that helps pharma companies develop their own treatments. Find out how they accumulated one of the world's largest proprietary brain datasets and why brain tissue is the “LiDAR of neuroscience.”Guests:INTVL: https://www.intvl.com.au/INTVL on Instagram: https://www.instagram.com/intvl.appLouis Phillips on Instagram: https://www.instagram.com/louisphillips12Verge Labs: https://vergelabs.com/Alice Zhang on X: https://x.com/AliceXinliZhangRelevant LinksMeta's Ad Library: https://www.facebook.com/ads/library/Strava: https://www.strava.com/Pokémon Go: https://pokemongo.com/Fitbod: https://fitbod.me/Tonebase: https://www.tonebase.co/Calm: https://www.calm.com/Hamilton Island official site: https://www.hamiltonisland.com.au/“Mr. Inbetween” trailer: https://www.youtube.com/watch?v=EooRG3QhQOYArticle: “Verge Genomics Rebrands as Verge Labs”: https://trial.medpath.com/news/verge-genomics-rebrands-as-verge-labs-following-als-drug-trial-failure-pivots-to-ai-driven-target-discoveryEli Lilly: https://www.lilly.com/Chai Discovery: https://www.chaidiscovery.com/Noetik: https://www.noetik.ai/Tempus: https://www.tempus.com/Timestamps:0:00 Louis on building in Melbourne, Australia7:44 Why INTVL ignores how fast you run9:59 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life!15:52 Using gamification for good19:10 Powering INTVL's impressive growth19:55 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST26:16 The future of TWiST Australia27:14 Will AI ever cure cancer?27:54 Inside Verge's rebrand30:31 Superhuman - Get AI that works where you work. Unlock your Superhuman potential at https://superhuman.com32:01 Brain tissue as "ground truth"36:01 Why brain tissue is so valuable as data43:52 Verge's Eli Lilly partnership51:34 "You're going to tell me when I'm going to die"56:11 How AI could impact drug prices58:19 Clinical trial FAILS and how to move onSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

While many tech companies race to build ever-larger AI models, IBM CEO Arvind Krishna sees the future differently. Speaking with host Bob Safian before a live audience during New York Tech Week, Krishna explains why enterprises are overcomplicating AI adoption, what kinds of risks leaders should be taking right now, and how to weigh AI's costs against its benefits. He also shares why IBM believes quantum computing will reshape the next era of technology.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Deel - deel.com/twistLinkedIn - linkedIn.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistPlaud - https://Plaud.ai/twistToday's show:Anthropic stabbed Cursor in the back. Then SpaceX swooped in with $60 billion. Today, TWiST connects the dots on the biggest deal in AI since the Microsoft-OpenAI partnership, and why it's a warning sign for every startup building on top of a frontier model. Jason is joined by Bling Capital's Ben Ling, Banana Capital's Turner Novak, and co-host Alex to go deep on the future of coding models, the current golden age of venture liquidity, OpenAI's financials, and the ‘Four Ds' of venture investing. The show closes with a tribute to Josh Baer, the founder of Capital Factory.Guest Links:Ben Ling https://x.com/bling0?lang=enBling Capital https://www.blingcap.com/Turner Novak https://x.com/TurnerNovakBanana Capital https://www.bananacapital.vc/Show Links:Hanover Park https://www.hanoverpark.com/SpaceX buys Cursor https://www.cnbc.com/2026/06/16/spacex-spcx-cursor-acquisition-ipo.htmlCursor Composer 2.5 https://cursor.com/blog/composer-2-5OpenAI financials source https://www.wheresyoured.at/exclusive-openai-financials/AMD's new deskside data center https://www.amd.com/en/products/processors/desktops/ryzen/ryzen-ai-halo.htmlPerplexity Model Council https://www.perplexity.ai/hub/blog/introducing-model-councilTimestamps:0:00 Guest introductions1:15 Guest introductions2:43 SpaceX acquires Cursor for $60B6:13 The golden era of M&A9:13 Northwest Registered Agent: Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist12:04 Cursor's negative gross margins & the compute problem13:22 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!15:04 Rolling your own model: When does it make sense?19:35 LinkedIn: Thanks to our partners at LinkedIn! Post your job for free at https://linkedIn.com/twist then promote it to get access to LinkedIn Jobs' new AI assistant.22:53 The "headless product" thesis28:31 Deel: Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.34:22 OpenAI financials leaked: $13B revenue, $38.5B net loss40:13 Where does AI value accumulate?45:34 Portfolio Spotlight: Hanover Park48:37 Seed stage graduation rates have fallen from 50% to 25%54:59 The four Ds of venture: Deal flow, Decisions, Doubling down, Distributions1:06:36 How to find 'undiscovered gems'1:30:59 Snap Specs AR glasses: $2,195, and a bit chunky1:39:29 Tribute to Joshua Baer, Capital Factory's founderSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

As America hurtles toward its 250th birthday, the world is watching. Ian Bremmer, Eurasia Group President and PBS host, joins Rapid Response to give his unvarnished read on the state of Brand America. He shares how he's advising business and political leaders around the globe, why he believes the US is overdue for a revolution, and what the widening gap between American wealth and American opportunity means for the country's standing in the world. Bremmer also reveals the defiant way he plans to celebrate July 4th, and makes the case for what it will take to extend the great American experiment another 250 years.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Week In Startups is made possible by:Every.io - visit every.ioSentry.io - sentry.io/twistVanta - vanta.com/twistToday's show:The next SpaceX won't be building rockets; it'll build the first hotel on the Moon. Today on TWiST, GRU Space founder Skyler Chan brings a brick made from lunar soil into the studio and lays out a plan to manufacture on the Moon as early as next year. We get into the science, the business model, and the regulatory land-grab ahead!Then, the US government forces Anthropic to pull Fable 5 and Mythos 5. Jason and Lon unpack what it means when a single AI model can vanish overnight, and the US government's emergency order.Stick around for the winner (or winners?!) of the $5,000 AI podcast-companion bounty!Timestamps:0:00 Knicks playoff run, San Antonio & Texas BBQ (Black's vs. Terry Black's)8:23 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!9:52 Guest intro: Skyler Chan, GRU Space — and the lunar-soil brick10:29 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io12:14 Why the next SpaceX builds habitats, not rockets15:18 NASA's $20B moon-base signal & the TRL contracting path16:13 Business model: from construction contractor to owning lunar land18:06 Building the hotel robotically + $1M refundable deposits20:00 Sentry - Your team should be focused on shipping features — not chasing down bugs. New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST31:09 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist39:28 News: US government blocks Anthropic's Fable 5 & Mythos 541:34 The politics: Hegseth, Sacks, Jassy & the "conspiracy" angle1:09:39 Why no single model dependency is safe (multi-model harnesses)1:18:47 Bounty results: MySidecast wins $3,0001:19:07 Honorable mentions: Couchverse (Lemon Slice) & Convalenz1:29:44 Next bounty: the Annotated app

RJ Scaringe is the founder and CEO of Rivian Automotive. Host Jeff Berman digs into how Scaringe thinks about competing with Tesla, the hard won lessons of building a company that makes both vehicles and software, and how the company is scaling to fuel the highly anticipated launch of its newest electric vehicle: The R2.This Masters of Scale Live event, sponsored by Atlassian, was recorded at Atlassian Team 2026 in Anaheim.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

He posted 400 times on Instagram with 50 followers. Most people would have quit. James Dumoulin just kept going.  I've been waiting to have this young man on for a while, and he did not disappoint. At 23 years old, James has built something I genuinely did not think was possible at this age: 21 million followers, 200 million views a month, 70 employees, and 48 billionaire interviews including Tom Cruise, Tom Brady, Will Smith, and Reid Hoffman. He built all of it from scratch, starting as a Chick-fil-A employee who saw TikTok as a marketing engine before anyone else did. James is the co-founder of the School of Hard Knocks, and what he has learned sitting across from the wealthiest people in the world will hit you in the best way possible. In this conversation, we go deep on what it actually takes to build something great when you have no connections, no credibility, and no one betting on you. James breaks down the exact strategy he used to get into rooms most people will never see, including how he cold-approached Mark Cuban at South by Southwest with nothing but nerve and a borrowed title. We talk about what the wealthiest people in the world actually have in common, whether money buys happiness, and why your age, your background, or your starting point is not the obstacle you think it is. James also gets honest about the moments where it almost fell apart, including the day their revenue dropped from $30,000 a month to under $5,000 overnight and what he did to rebuild. This is one of the most practical, fire conversations I've had in a long time, and James is the real deal. Here's what you'll gain from this episode: The Authority Hack: How James borrowed credibility he didn't have yet to get in rooms most people will never see, and how you can do it starting today with what you already have. Billionaires Think in Decades: The single mindset shift James observed in every billionaire he's interviewed, and why your obsession with the short term is the real thing holding you back. Concentration Builds Wealth: Why trying to do too many things too early is the silent killer of most businesses, and what the wealthiest people actually do first. The Rejection Blueprint: Why James says "no" just means "not yet," and how posting 400 times with 50 followers is what actually built a business doing $700,000 a month. Are Billionaires Actually Happy? What James has witnessed behind the scenes with some of the most successful people in the world, and the one thing the happiest ones all have in common.  This is one of those conversations that changes the way you think about what's actually possible. Don't miss this one! Try QUO for free PLUS get 20% off your first 6 months when you go to ⁠https://quo.com/mylett Get your choice of a healthy free protein staple like chicken breast for a year or ground beef in every box for LIFE PLUS $20 off when you go to https://ButcherBox.com/mylett

As the World Cup kicks off this Thursday, scrutiny surrounds ticket prices, disrupted fan travel, potential ICE activity, and FIFA's murky dealings. ESPN Global Sports Correspondent Sam Borden has covered this tournament from Brazil to Qatar, and he joins Rapid Response to break down the USA's real chance, what Iran's presence on American soil actually means, and whether hosting the world's biggest sporting event is a blessing or a liability right now. Plus, Borden makes the most passionate case you'll hear for why the World Cup matters more than any scoreline.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

While legacy news outlets like The Washington Post stumble, The Guardian keeps growing — but how? Guardian Media Group CEO Anna Bateson joins Rapid Response to pull back the curtain on the company's unusual ownership structure and the multi-revenue model fueling its resilience. Bateson also weighs in on the threat and opportunity of AI chatbots, the Jeff Bezos effect on media, and what role she sees The Guardian playing as the future of news takes shape, even as the pressures of today demand her full attention.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.