Podcast appearances and mentions of Reid Hoffman

Download this week's deck: http://diamandis.com/wtf  Get access to metatrends 10+ years before anyone else - https://qr.diamandis.com/metatrends   Grab dinner with MOONSHOT listeners: https://moonshots.dnnr.io/  Salim Ismail is the founder of OpenExO Dave Blundin is the founder & GP of Link Ventures Dr. Alexander Wissner-Gross is a computer scientist and founder of Reified, focused on AI and complex systems. Reid Hoffman is an entrepreneur, investor, and LinkedIn co-founder focused on AI and human progress. – My companies: Reverse the age of my skin using the same cream at https://qr.diamandis.com/oneskinpod   Apply to Dave's and my new fund:https://qr.diamandis.com/linkventureslanding   – Connect with Peter: X Instagram Connect with Dave: X LinkedIn Connect with Salim: X Join Salim's Workshop to build your ExO: https://openexo.com/10x-shift?video=PeterD062625 Connect with Alex Website LinkedIn X Email Connect with Reid X LinkedIn Listen to MOONSHOTS: Apple YouTube – *Recorded on September 11th, 2025 *The views expressed by me and all guests are personal opinions and do not constitute Financial, Medical, or Legal advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Pablos Holman is a hacker and inventor and the author of Deep Future: Creating Technology that Matters, the indispensable guide to deep tech. Previously, Pablos worked on spaceships at Blue Origin and helped build The Intellectual Ventures Lab to invent a wide variety of breakthroughs. Pablos also hosts the Deep Future Podcast and is managing partner at Deep Future.This episode is brought to you by:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/timMaui Nui Venison​, delicious, nutrient-dense, and responsible red meat: https://mauinuivenison.com/lp/timAG1 all-in-one nutritional supplement: https://drinkag1.com/timTimestamps:00:00 Intro02:12 The hacker mindset33:05 Nuclear52:35 Autonomous ships58:48 Pragmatic optimism01:00:29 Risk tolerance01:04:50 Blue Origin01:11:59 Zero Effect philosophy01:34:43 China01:43:07 Taiwan01:45:04 AI01:50:42 Salsa02:08:44 Deep tech investing*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

As the fashion world navigates an unprecedented wave of turnover from Chanel to Dior, WSJ. Magazine's Editor in Chief, Sarah Ball joins Rapid Response to explore the most closely watched New York Fashion Week in years — what she calls "a September to remember." Ball also shares insights about how Vogue is poised to take shape post-Anna Wintour, the shockwaves from Georgio Armani's recent passing, AI's impact on fashion creatives, and how the role of influencers and social media is noticeably reshaping where the industry is headed.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The future is something we create, not just something that happens. To guide progress toward real good, we need bold, optimistic visions of what society can become.Reid Hoffman makes the case for better science fiction - stories that don't just entertain, but illuminate the futures we can strive for. As a serial entrepreneur and cofounder of LinkedIn, Reid brings a unique perspective on how storytelling shapes technology, society, and innovation. He argues that imagining optimistic futures is essential if we want to create them.In this episode, we also explore how technology like AI is changing the way our brains work and how our faculties will evolve, why humanity has shifted from focusing on external threats to internal ones, and how optimism isn't blind faith—it's a clear-eyed strategy for shaping a better world.This is... A Bit of Optimism. Check out Reid's new book here: https://www.superagency.ai/SUPERAGENCY: What Could Possibly Go Right with Our AI Future

Today's show:On a special edition of TWiST, Alex presents a trio of TWiST 500 interviews.First up, Medium CEO Tony Stubblebine on the company's new Really Simple Licensing (or RSL) initiative, and how it's helping to compensate writers for their content.THEN, Human Native CEO Dr. James Smith joins for an even deeper dive on AI licensing, why a writer's content isn't just DATA to them, and why the company is pivoting away from its old marketplace model.FINALLY, Jason Marks of TELO Trucks stops by to show off his EV mini-truck, walk us through why people need a powerful but tiny truck, and explain why they're building trucks right here in the US of A.Timestamps:(0:00) Intro: It's a trio of TWiST 500 interviews today!(02:57) Alex chats with Medium CEO Tony Stubblebine(04:54) Why Medium's more worried about HIDING from AI than anything else(10:24) Nexos.ai. Stop Shadow AI in its tracks with the unified platform for secure AI adoption and productivity. Try it with a free 14-day trial at nexos.ai/twist.(11:27) Show Continues…(15:02) What is RSL and why aren't AI companies offering publishers a good value?(19:58) Gusto. Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at Gusto.com/twist.(20:59) Show Continues…(22:03) How Medium calculates its revenue split with writers(26:57) Alex welcomes Human Native CEO/founder Dr. James Smith.(27:34) Writers see their content as their life's work, but tech co's just see DATA(30:01) DevStats translates complex engineering metrics into a shared language everyone at your company can understand. Get 20% off by going to DevStats.com/twist(31:06) Show Continues…(33:01) Why H.N. is pivoting away from licensing and the marketplace model(47:23) TELO Trucks CEO Jason Marks joins the show(48:25) What is a “mini-truck” and why they're TELO's focus(52:28) Why TELO is building their EV trucks right here in the US(54:42) Why towing capacity still matters, even on a mini-truckSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:Nexos.ai. Stop Shadow AI in its tracks with the unified platform for secure AI adoption and productivity. Try it with a free 14-day trial at nexos.ai/twist.Gusto. Check out the online payroll and benefits experts with software built specifically for small business and startups. Try Gusto today and get three months FREE at Gusto.com/twist.DevStats translates complex engineering metrics into a shared language everyone at your company can understand. Get 20% off by going to DevStats.com/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Today's show:There are new LAUNCH Accelerator and Founder U cohorts this week, and Jason's running down some of his favorite new startups.PLUS Alphabet is the latest member of the $3T club, why Eric Schmidt was SO RIGHT about remote work, Robinhood is opening up private companies to more investors, Polymarket adds earnings reports, how Jason wagered on The Emmys this year, and MORE!Timestamps:(0:00) It's kickoff day for LAUNCH Accelerator 35 AND Founder University!(02:32) Let's talk about some new companies. Jason runs down the LA35 line-up and why he's excited about these awesome startups.(10:33) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at https://www.openphone.com/twist(11:57) Show Continues…(19:50) Squarespace - Turn your idea into a beautiful website! Go to http://www.squarespace.com/twist for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain.(21:05) Show Continues…(27:43) Lemon.io - Hire pre-vetted remote developers and get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(28:58) Looking back at Jason's solar energy rematch vs. Energy Sec. Chris Wright.(31:23) Why Jason thinks solar power (+nuclear) is the future.(41:03) Why Alphabet is the latest member of the $3 trillion market cap club.(46:40) Jason says Eric Schmidt was right about work from home culture(48:51) How Robinhood is giving everyday investors access to private companies(51:44) Polymarket introduces prediction markets for corporate earnings.(53:58) Why Jason loves prediction markets… and how he gambled on the Emmys this year.Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at https://www.openphone.com/twistSquarespace - Turn your idea into a beautiful website! Go to http://www.squarespace.com/twist for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain.Lemon.io - Hire pre-vetted remote developers and get 15% off your first 4 weeks of developer time at https://Lemon.io/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

On the latest episode of Reid Hoffman's Possible podcast, he and Aria talk with comedian Stephen Colbert. They discuss how J.R.R. Tolkien helps The Late Show host make sense of AI, whether technology will ever be able to replicate the ‘micronutrients' of human interaction, and more. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:On Friday's TWiST, Jason, Alex, and Lon look back at some highlights from this week's big All-In Summit in Los Angeles, including a fiery, no holds barred presentation from Palantir CEO Alex Karp, Elon Musk delving into the key challenges facing Optimus, and Tucker Carlson debating Mark Cuban on Ukraine. PLUS… why schools may start blocking social media apps, the FTC's new investigation into social chatbots, AND omnidirectional Zoox robotaxis are headed to Las Vegas.Timestamps:Welcome back to TWiST!(1:52) Jason's thoughts on the killing of Charlie Kirk(10:34) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(10:52) Show Continues …(12:15) Reacting to All-In Summit highlights (Elon Musk, Alex Karp, Tucker Carlson, Mark Cuban)(21:23) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/credits(22:18) Show Continues …(26:09) Palantir, Alex Karp, and debate dynamics(31:03) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist(32:13) Show Continues …(45:03) How the internet used AI tools to make sense of Charlie Kirk's death(56:22) Why Jason thinks it's smart to block social media during school hours(1:03:43) The FTC chatbot investigation leaves out Anthropic's Claude… here's why(1:13:27) Zoox robotaxis make their Vegas debut… Here's how they're different from Waymo(1:19:38) Are Tesla robotaxis headed for CA soon? Polymarket says… maybe(1:27:21) Closing remarks and banterSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWISTAWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/creditsPublic - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Podcast description: Matthew Pohlson's dreams of building a company were almost cut short by a near-death experience. The CEO and co-founder of Omaze reveals how it changed his mindset, and unlocked new ways to scale his business. Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

God's Debris: The Complete Works, Amazon https://tinyurl.com/GodsDebrisCompleteWorksFind my "extra" content on Locals: https://ScottAdams.Locals.comContent:Politics, Charlie Kirk, Van Jones, Governor Pritzker, Elizabeth Warren, Matthew Dowd, Republicans Hunted, President Obama, Stephen Miller, Terry Wilson BLM, TMZ Cheer, Hypnotized democrat Celebrations, Mike Cernovich, Reid Hoffman, Risk Tolerance, democrat Leadership, Elon Musk, Matt Von Swol, President Trump, Code Pink Protesters, PM Netanyahu, Risk Management, Recency Bias, Palmer Luckey, Ryan Routh Trial, Scott Adams~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~If you would like to enjoy this same content plus bonus content from Scott Adams, including micro-lessons on lots of useful topics to build your talent stack, please see scottadams.locals.com for full access to that secret treasure.

Today's show:In this founder-focused episode of This Week in Startups, we sit down with Republic's Kendrick Nguyen to learn more about the company's efforts to make the private markets accessible to the common investor. Best known for its work in equity crowdfunding, the Valor-backed startup now offers access to secondary shares, tokenized assets, and much more. Following, TWiST spoke with Positron CEO Mitesh Agrawal to learn more about his company's inference-focused AI compute hardware. Related to fellow TWiST500 company Etched, Positron is building custom chips to take on the computing work required to deliver your AI query results faster and with less power draw than what GPUs can offer. With AI inference compute demand rising, the fellow Valor-backed startup has even more powerful systems coming to market in 2026 that have our hopes up that the AI cost curve can continue to point downward.Timestamps:0:00 - A future with more efficient and accessible intelligence0:41, the following sponsors are mentioned: AlphaSense, Vanta, and Oracle Cloud Infrastructure1:26 - Introduction to the episode and the two featured companies, Republic and Positron2:43 - The history and purpose of Republic, a financial crowdfunding platform5:39 - Discussion of the current state and growth of equity crowdfunding9:19 - Kendrick Nguyen explains Republic's role as a financial infrastructure company, not a competitor to venture capital firms11:17 - Sponsor: Oracle Cloud Infrastructure12:25 - Republic's different products, Republic Capital and Republic Venture, are explained14:00 - The challenges and progress of secondary trading for non-accredited investors20:14 - Sponsor: Vanta21:21 - The concept of a unified "e-finance" infrastructure is introduced25:45 - Positron CEO Mitesh Agarwal discusses the future of AI chips and the limitations of current GPUs for inference workloads31:12 - Sponsor: AlphaSense32:22 - Discussion on the inefficiency of GPUs for inference and how Positron's Atlas system addresses it38:30 - Positron's strategy of using their Atlas system to prove their technology and generate revenue42:51 - The market shift from AI training to inference and the future of Positron's chips51:14 - The confidence in Positron's capital efficiency and their ability to compete with NVIDIA52:47 - Positron's focus on linear algebra acceleration rather than just transformersSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(09:04) Netsuite - Download the ebook CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(21:20) Coda - Empower your startup with Coda's Team plan for free—get 6 months at https://www.Coda.io/twist(31:43) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

What could we gain—and what might we lose—when technology begins to approximate the contours of human connection and presence? In this episode, Reid and Aria chat with comedian, actor, and political commentator Stephen Colbert. Best known for hosting The Colbert Report and The Late Show, Stephen combines a razor sharp satire with a sincere curiosity about the world. Together, Reid, Aria, and Stephen discuss the art of live performance, the many lessons one can learn from J.R.R. Tolkien, and the nature of creativity, humor, and imagination in the age of AI. The result is a meditation on discovery, empathy, and the bonds that make connection more than performance — but a shared act of being human. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/  Topics: 2:35 – Hellos and intros 2:53 – Stephen Riffs on humanity and Dungeons & Dragons  6:08 – Tolkien characters and desert island companions 7:02 – Creativity, empathy, and imagination in comedy 11:37 – Performing for a live audience 13:02 – Comedy as a third space 16:22 – Early ideas about interactive technology and improvisation 19:14 – Can AI art escape the uncanny valley 22:27 – The human “micronutrients” that AI cannot replace 24:05 – Parasocial relationships and the future of entertainment 26:50:– Midroll 26:58 – Responsibility and fact-checking 29:56 – Personalization versus discovery in AI storytelling 33:47 – Lessons from Tolkien 41:22 – AI as part of human evolution 44:51 – How AI can already be employed in health fields 48:46 – AI in video games and creative amplification 49:58 – Balancing skepticism and excitement about AI 50:06 – Rapid-fire Questions Select mentions:  A Man Jumps Out of an Airplane by Barry Yourgrau Exploring The Lord of the Rings with Dr. Corey Olsen Letter 144 by J.R.R. Tolkien  Robert Heinlein Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

This episode is a solo Q&A session where I answer a bunch of questions. We covered a ton of ground, from personal health protocols to professional frameworks and creative projects. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Timestamps: [00:00:00] Start[00:06:00] Coyote retail distribution challenges and data gathering.[00:09:12] Elbow surgery recovery: sequencing, decongestion, Marc Pro device, peptides, BFR training.[00:16:14] California vs. Austin for builders, mechanical engineers, and tech startups.[00:19:06] Using AI for medical advice workflow (and cross-referencing with professionals).[00:23:51] Current supplement regimen and PAGG/AGG status.[00:31:54] California vs. Texas considerations for aspiring parents.[00:32:48] Saying "No" to good things for "Hell, yes" moments.[00:34:34] Philanthropy lessons learned since starting Saisei Foundation.[00:37:45] Something I've changed my mind about recently: intermittent fasting.[00:42:44] Precious items from childhood I still keep: D&D relics and marine biology books.[00:43:03] Bucket list hike: Glacier National Park.[00:43:42] How the catalytic chaos of publishing The 4-Hour Chef led to launching this podcast.[00:45:52] Bringing delight vs. sixth-gear, high-performance focus.[00:49:05] Thoughts on extended human fasting research from the Soviet era.[00:52:58] Most magical New Mexico experience: Mountain Cloud Zen Center meditation retreat.[00:53:22] Meta skills for the AI era: Hyper-adaptability and world-class learning.[00:54:01] The (real and ideal) future of CØCKPUNCH/Legends of Varlata.[00:59:47] Competitive chess training enhancement: glucose management, intermittent fasting, MCT oil.[01:06:31] Behind-the-scenes projects: Fusion, algae feed additives, meat alternatives.[01:08:32] Countries I wish I had visited earlier, and places I'd still like to see.[01:11:06] "Not yet" vs. "No" in early growth phases.[01:14:14] Post Coyote, do I have any future games in the works?[01:14:46] Over-ear vs. in-ear headphones for podcasting.[01:15:16] What's the uncrowded channel right now?[01:16:17] Recommendations for Dr. Mindy Pelz.[01:16:58] Robert Rodriguez and project juggling.[01:17:24] Fast neutron reactors and the Bugatti of ketones.[01:19:05] Extended family outings and Mahonk Mountain House.[01:20:31] NO BOOK meetup plans?[01:20:54] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sunday's MTV Video Music Awards shone a light on some of the biggest storylines in the music business today – from the TikTokification of newly minted stars, to the evolving relationship between artists and brands. Music journalist and author Sowmya Krishnamurthy joins Rapid Response to break down business and cultural lessons from the show and what it reveals about the state of the industry. Krishnamurthy also explores Taylor Swift's enduring dominance, the role of AI in music, and the latest twists in the streaming war between Spotify and Apple Music.Visit the Rapid Response website here: https://www.rapidresponseshow.com/Find Sowmya's book Fashion Killa here: https://www.simonandschuster.com/books/Fashion-Killa/Sowmya-Krishnamurthy/9781982176327See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:In this TWiST founder triple-shot, Alex digs into the real-world rollout of AI agents: Paid.ai's Manny Medina explains agent economics and value-based pricing, iTruckr's Camilo Ramirez shows agents booking loads and coordinating drivers, and Tenax's Elise Myrans demos computer vision + drones that score a single home's wildfire/flood risk for smarter underwriting—plus live office-hours on winning enterprise pilots without getting stuck in PoC purgatory.Timestamps:(00:00) Brainstorming hacks for sales cycles in regulated industries — castles, moats & alligators!(03:50) Meet Paid.ai: tracking costs & monetization for AI agents(04:35) Paid.ai's Manny Medina on the “year of agents” & early enterprise traction(09:04) Netsuite - Download the ebook CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(11:06) The tough economics of AI agents vs SaaS — margins squeezed by tokens(18:20) How Paid.ai gets granular: tracking signals & agent activity with OpenTelemetry(21:20) Coda - Empower your startup with Coda's Team plan for free—get 6 months at https://www.Coda.io/twist(29:16) Enter iTruckr: Camilo Ramirez brings AI dispatch to the freight industry(31:43) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(39:02) Scaling from small fleets to mid-sized trucking companies — lessons from AI Trucker(55:59) Tenax ai helps homeowners & insurers manage wildfire, flood & climate riskSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(09:04) Netsuite - Download the ebook CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(21:20) Coda - Empower your startup with Coda's Team plan for free—get 6 months at https://www.Coda.io/twist(31:43) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Today's show:Jason heard Lina Khan on The Bulwark and got a little fired up.Plus Google doesn't have to invest in Chrome… or basically do much of anything… Atlassian picked up not just any browser company but THE Browser Company… Follow-up thoughts on that MIT “companies aren't using AI” study… AND Jason's “two stock markets” theory. It's a can't-miss Friday TWiST.Timestamps:(00:00) Sony responds to Kpop Demon Hunters success… but Jason's not buying it!(10:44) Sentry - New users get 3 months free of the Business plan (covers 150k errors). Go to http://sentry.io/twist and use code TWIST(11:10) Jason heard Lina Khan on The Bulwark and he has THOUGHTS(12:40) Google doesn't have to divest Chrome! So what ARE the remedies?(18:31) Atlassian's buying a browser company? Which one? THE Browser Company.(20:57) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech(21:22) When early DPI is better than NO DPI.(26:58) AI that helps you GET a job?! What a twist!(29:46) Jason and Alex have questions about that MIT AI study…(30:57) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.(32:07) More Browser News! Why Jason's bullish on Brave.(35:10) Perplexed by “Perplexity”: Jason's rules for domain names(39:54) The path is cleared for Polymarket's return to the US(47:06) Jason's “Two Stock Markets” theory(53:02) Mistral looking to raise 2 billion… euro!(56:08) Jason's political philosophy: More joy and happiness(59:18) Stripe's new stablecoin blockchain has no native token! So what's it for?(01:04:12) Jason's tips for lowering your churn rate(01:11:56) How to use Reddit to uncover pain pointsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:44) Sentry - New users get 3 months free of the Business plan (covers 150k errors). Go to http://sentry.io/twist and use code TWIST(20:57) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech(30:57) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

As the NFL season kicks off this week, host Jeff Berman talks with a serial entrepreneur known for innovating in fantasy sports. Jeremy Levine is the founder and CEO of Underdog, a rapidly scaling unicorn. Levine reveals how a relentless focus on product helps his company break through entrenched competition.Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:Jason and Alex are joined by Nuro's Dave Ferguson to unpack the Lucid–Uber–Nuro deal aiming to launch fully driverless Gravity SUVs on Uber by 2026. They dig into why off-the-shelf sensors and Nvidia's Thor chip drive costs down, how mapping 150 cities improves safety, and why lidar still matters for night and edge cases. Plus: lessons from Cruise's collapse, how regulators think about safety multiples, and why autonomy could finally make rides cheaper than owning a car.Timestamps:(00:00) Show intro…(06:23) Uber x Lucid x Nuro: why this 2026 robotaxi deal matters(09:57) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(11:13) What the self-driving “cost stack” really looks like in 2025(14:08) Road-mapping at scale: Nuro's 150-city data collection push(15:38) Can AVs handle snow & rain? Weather rollout and Uber Black positioning(20:05) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(21:07) Show Continues…(24:24) Probabilistic vs. deterministic driving models — and the DARPA roots(30:08) Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on stripe.com/startups.(31:08) Show Continues…(35:38) Post-Cruise reality check: transparency, regulators & trustSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(09:57) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(20:05) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(30:08) Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on stripe.com/startups.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Today's show:Find out why it's important to “get curious,” and more deep founder insights on a new TWiST.Jason and Alex are back with a look at Robot vs. Human violence spilling out into the streets, Elon Musk's vision for humanoid robots, and a reconsideration of Apple's open-source AI models. Is the hardware giant not getting enough credit for its smaller-scale innovations?Plus Grok has another hit model, AND a chat with Scale Social founder Runbin Dong about the importance of knowing your worth.Timestamps:(0:00) Robot vs. Human violence in the streets! Is anti-clanker behavior inevitable?(05:13) Producer Claude's company Anthropic is growing FAST, raising BIG money(09:21) More on why Jason is convinced Tesla's Optimus robots are the future(10:35) Monarch Money - Get 50% Off Monarch Money, the all-in-one financial tool at www.monarchmoney.com/TWIST(11:50) Show Continues…(20:00) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(21:19) Show Continues…(23:31) Ask Jason: Should you get a ticket for messing with an autonomous vehicle?(27:04) Is Apple not getting enough credit for its open-source AI models?(30:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(31:55) Show Continues…(38:08) Grok has another hit AI model… how can anyone even keep track of this?!(40:27) Runbin Dong of Scale Social stops by from ICELAND(42:54) How Runbin's job delivering homemade dumplings inspired his startup(47:05) Why founders need to know their WORTH when pricing their products(59:21) Jason's advice for companies that are creating their own categorySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:35) Monarch Money - Get 50% Off Monarch Money, the all-in-one financial tool at www.monarchmoney.com/TWIST(20:00) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(30:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/creditsGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Sam Chaudhary is the co-founder and CEO of ClassDojo, a multi-product education platform used in 95% of U.S. schools and over 180 countries globally to connect teachers, students, and families. In this episode, Sam shares the full arc of building ClassDojo, from early skepticism about education and a failed group-making tool, to creating a communication platform loved by millions. In this episode, we discuss: Why ClassDojo was built for consumers (teachers, students and parents) instead of schools How ClassDojo grew entirely by word-of-mouth Sam's unusual approach to building multiple new businesses The founder mindset required to build an industry leader Why relentless resourcefulness is an underrated skill And much more… References: Accel: https://www.accel.com/ Airbnb: https://www.airbnb.com/ Bill Gates: https://www.linkedin.com/in/williamhgates/ Brendan Kereiakes: https://www.linkedin.com/in/product/ ClassDojo: https://www.classdojo.com/ Dominick Bellizzi: https://www.linkedin.com/in/dominickbellizzi/ Geoff Ralston: https://www.linkedin.com/in/geoffralston/ Gonzalo Aguilar Málaga: https://www.linkedin.com/in/gonzalodecheck/ Hamilton Helmer: https://www.linkedin.com/in/hamilton-helmer-42983/ Imagine K12: https://www.imaginek12.com// Khan Academy: https://www.khanacademy.org/ Liam Don: https://www.linkedin.com/in/liamdon/ McKinsey: https://www.mckinsey.com/ Paul Graham: https://x.com/paulg Plaid: https://plaid.com/ Reid Hoffman: https://www.linkedin.com/in/reidhoffman/ Roblox: https://www.roblox.com/ Sal Khan: https://www.linkedin.com/in/khanacademy/ Superhuman: https://superhuman.com/ Tim Brady: https://www.linkedin.com/in/tim-brady-7a632510/ Y Combinator: https://www.ycombinator.com/ Where to find Sam: LinkedIn: https://www.linkedin.com/in/samchaudhary/ Twitter/X: https://x.com/samchaudhary Where to find Brett: LinkedIn: https://www.linkedin.com/in/brett-berson-9986094/ Twitter/X: https://twitter.com/brettberson Timestamps: (01:36) Why education is a “bad market” (02:52) Why enterprise education is broken (03:35) Building for families, not schools (06:53) Early challenges and insights (09:45) Sam's unusual background (11:42) Meeting co-founder Liam at a hackathon (13:22) Getting into Imagine K12 with a group-making tool (19:47) The conversation with Reid Hoffman that changed everything (21:52) Building a network to reach more families (23:30) Scaling by building a community (33:18) Designing for delight and word-of-mouth growth (40:09) Launching the first monetization feature after 7 years (41:35) How to pick markets and when to go broad (46:04) The explosive expansion into the tutoring industry (55:11) Creating safe online spaces for kids (58:01) Harnessing AI in education (59:52) Lessons from ClassDojo's playbook

Grab is a rideshare service-turned superapp, not available in the US but rapidly growing in Southeast Asia. It's even outmaneuvered global players like Uber to reach a valuation north of $20 billion. Grab's co-founder and CEO Anthony Tan joins Rapid Response to share how the platform has successfully expanded into food delivery and fintech, while also investing in the future of electric vehicles and autonomous driving. For any leader looking to bolster their company culture to meet the moment, Tan shares how his team set in motion an ambitious project to study and creatively implement AI — channeling both the hunger and humility to win in a competitive and chaotic market.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:*“KPop Demon Hunters” is one of the year's biggest smashes… AFTER Sony sold it off to Netflix for cheap! Hear about what went wrong with one of the year's worst deals…PLUS Grok is counting on SPEED to help it outpace rivals… How Rep. Ritchie Torres (D-NY) ran into trouble on the podcast circuit… Nvidia's big earnings report, and why everyone is watching that company in particular SO closely… PLUS a new Polymarket predicting the future of OpenAI!Timestamps:(0:00) How Sony missed out on “Kpop Demon Hunters”(10:15) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(11:20) Show continues…(13:59) Why some politicians struggle so much on podcasts(19:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(20:53) Show continues…(30:24) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twist(31:37) Grok is relying on SPEED to outpace rivals… and it's working(41:23) Are AI companies playing a mega-budget game of chicken?(42:31) Why everyone's watching Nvidia's earnings so closely(47:50) Jason says he'll NEVER go back to a non-AI browser(53:32) Polymarket: Is OpenAI going to release their own browser?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:15) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(19:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(30:24) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twistReady to level up your AI collaborations?Head to www.claude.ai/twistYou can't do everything we're doing without a paid plan…But TWiST listeners get 50% off their first three months of Claude Pro.Just go to Claude dot AI Slash TWiST to get started.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

For our latest Strategy Session, Reid Hoffman and Kickstarter CEO Everette Taylor answer questions from entrepreneurs about how to build more resilient businesses. They share frameworks for taking smarter risks, finding co-founders, and more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:On a brand-new TWiST, Jason and Alex are asking why there are SO MANY note-taking AI apps?Plus another death has been linked to ChatGPT… is it too easy to get past chatbot guardrails? Why Donald Trump Jr. is joining Polymarket…. How the US Navy could catch up with its international rivals… AND should Apple just buy a big AI company to help them catch up?All that PLUS a visit from Colin Russ, whose viral H1B Visa thread might just inspire Jason to reach out to his good friend, Vice President JD Vance. Check out the full episode!Timestamps:(0:00) Intro, Jason's checking out Notion's new AI note taking app… is it time to cancel Granola?(06:57) How Google Gemini's new 2.5 Flash Image tool (formerly known as “nano-banana”) could change advertising(10:28) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(11:40) Show Continues…(17:50) Another death linked to ChatGPT… is it too easy to get around AI chatbot guardrails?(19:26) Vouched - Trust for agents that's built for builders like you. Check it out at http://vouched.id/twist(20:34) Show Continues…(28:10) Donald Trump Jr. invests in Polymarket and joins the board…(29:45) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(30:49) Show Continues…(33:30) How Jason thinks the US Navy could catch up with China and other rivals, with help from startups(40:01) Do Jason and Alex think Apple might REALLY buy a big, expensive AI company? Would that be admitting defeat?(45:57) Colin Russ (@ThaaatColin) tells us about his viral X thread and why he's worried about H1B visa fraud(55:32) Jason's solution for the H1B system, and a message for VP Vance.(01:08:25) Jason responds to Kara Swisher, who accused him sucking up to power(01:19:07) Jason responds to his old pal Sam Harris, who thinks he's loyal to the wrong peopleSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:28) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(19:26) Vouched - Trust for agents that's built for builders like you. Check it out at http://vouched.id/twist(29:45) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Gains in the quality of America's K-12 education in the late 20th and early 21st century have largely plateaued—and , in several instances, reversed—in the last few decades. This week, Alpha School co-founder MacKenzie Price joins the show to discuss her fast-expanding network of AI-powered private schools, which she says represent the reform the system so badly needs. She explains why Alpha students learn core academics in two hours a day via a personalized learning platform—not human teachers—and then devote the rest of the school day to passion projects, life skills, and real-world learning. Plus, we hear from Alex, a high school senior at Alpha's Austin, TX location, about his experience.  For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/  Topics: 3:45 - Hellos and intros 4:12 – MacKenzie's path from Stanford psychology to Alpha Schools 6:11 – Updating traditional school systems with AI 7:46 – What makes Alpha Schools different 12:01 – The 2-Hour Learning model  15:40 – Key lessons from AI in classrooms  18:11 – AI supercharges students with the “four C's”: critical thinking, communication, collaboration, creativity 20:47 – Teacher-student connection and mentorship  21:54 – Scaling Alpha Schools & lowering costs 25:47 – AI-driven assessment & personalized learning plans 29:38 – Midroll 29:47 – Alex shares his experience as an Alpha School student and entrepreneur  34:19 – Challenges of scaling   36:09 – Student incentives & using Alpha currency to teach kids financial literacy 38:55 – Alpha students learn life skills & develop entrepreneurial projects  41:44 – GT School for highly accelerated learners 44:55 – “Future of Education” podcast highlights 47:16 – Teachers vs. guides & redefining expertise in education 49:21 – Using AI for public speaking & coaching 51:02 – Rapid fire questions Select mentions:  Alpha School, AI-Driven Education Founded in Austin, Is Coming to More Cities — New York Times: https://www.nytimes.com/2025/07/27/us/politics/ai-alpha-school-austin-texas.html  Future of Education Podcast: https://futureofeducationpod.com/  Berry: https://berryplush.com/  Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

AGI is coming. Reid Hoffman just wrote the book on how to prepare.According to Reid, every major tech breakthrough (the written word, the printing press, the telephone) triggered mass fear. But, contrary to our worries, new technology tends to enhance human agency—even more so, if you know how to use it well.Reid is the cofounder of LinkedIn, Inflection AI, and Manas AI; a partner at venture capital firm Greylock Partners; an early backer and board member of OpenAI; and an award-winning podcasterWe spent an hour talking about how to develop a compass for navigating AGI. Here are a few takeaways:Our sense of human agency is not just about external control but an internal stance—how we approach uncertainty & new tech is crucialIn new technology waves, NO blueprint or plan will have the right answers. Instead, adapting to new technology requires broad access, an experimental mindset, and flexibilityIn an AGI world most jobs will transform, not disappear—and how you can prepare with hands-on trial and errorHow certain social norms and ethics should change as AGI changes the landscape—like individual access to personal dataWhy now may be finally be the era where quantified self tools become valuable…and more, including everything in his new book Superagency, out this week.It was a pleasure to have him on the show for a second time. This is a must-watch for anyone who wants to help build a more human future with AI.If you found this episode interesting, please like, subscribe, comment, and share!Want even more? Sign up for Every to unlock our ultimate guide to prompting ChatGPT here: https://every-2.kit.com/ultimate-guide-to-prompting-chatgptIt's usually only for paying subscribers, but you can get it here for free.To hear more from Dan Shipper: Subscribe to Every: https://every.to/subscribe Follow him on X: / danshipperSponsor:Attio is the AI-native CRM built for the next era of companies. With Attio, setup takes minutes. Connect your email and calendar, and it instantly builds a CRM that mirrors your business. Go to https://www.⁠⁠⁠⁠attio.com/every to get 15% off on your first year.Timestamps:00:00:00 — Episode Start00:01:29 — Introduction00:02:50 — Patterns in how we've historically adopted technology00:07:02 — Why humans have typically been fearful of new technologies00:13:25 — How Reid developed his own sense of agency00:20:08 — The way Reid thinks about making investment decisions00:22:00 — Attio: Go to⁠⁠⁠⁠ https://attio.com/every⁠⁠⁠⁠⁠ and get 15% off your first year on your AI-powered CRM.00:29:40 — AI as a "techno-humanist" compass00:35:30 — How to prepare yourself for the way AI will change knowledge work00:41:39 — Why equitable access to AI is important00:45:15 — Reid's take on why private commons will be beneficial for society00:47:23 — How AI is making Silicon Valley's conception of the "quantified self" a reality00:52:14 — The shift from symbolic to sub-symbolic AI mirrors how we understand intelligence01:03:29 — Reid's new book, SuperagencyLinks to resources mentioned in the episode:Reid Hoffman: @reidhoffmanSuperagency, Reid's newest book: https://www.superagency.ai/

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim's intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint's RA implant + Kelly Owens's turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what's just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn't)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf's setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what's next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

AI tools are disrupting all types of creative content, and Runway AI is a pioneer making major waves in Hollywood. It's partnering with the likes of Disney and Netflix to revolutionize production. Runway's co-founder & CEO Cristóbal Valenzuela joins Rapid Response to dissect the company's breakneck growth, the risks and responsibilities of AI tool makers, and how AI is redefining both business expectations and our notion of creativity. Cristóbal also reveals why he rebuffed advances from Meta for a highly lucrative acquisition, and how AI video is just a stepping stone to an entirely new media format — one more expansive and transportive than we can realistically comprehend today.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:On an upbeat and optimistic new TWiST, Jason and Alex are debating why any new innovation or technology gets hit with a wave of bitter cynicism.PLUS Jason defends the government taking shares of Intel, explains the importance of interoperability, and predicts how AirBnB's Joe Gebbia will upgrade the US government's website design.All that PLUS thoughts on the Netskope IPO, Perplexity offering publishers actual revenue share, a deep dive on the new AI-based PAC, thoughts on open-source LLMs, and much much much more.Timestamps:(0:00) Cynicism vs. Optimism and why Jason thinks cynics go after any interesting new technology(10:02) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist(11:04) Show Continues…(14:37) Why Jason supports the Intel deal but worries it will become a trend(20:46) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.(22:00) Show Continues…(27:02) Is it hypocritical to oppose socialist grocery stores but support the Intel deal? Jason says NO.(29:41) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(30:58) What does xAI hope to get out of this OpenAI/Apple lawsuit? Jason and Alex theorize…(39:12) Why Jason thinks interoperability is so important and how App Stores OUGHT to work(41:12) How AirBnB's Joe Gebbia could potentially upgrade the US government's websites(49:27) What does Netskope do exactly? SASE?! Producer Claude explains…(58:32) Alex and Jason celebrate Perplexity rev sharing with publishers(01:10:02) Jason's thoughts on the Leading the Future PAC, and US AI policySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:02) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist(20:46) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.(29:41) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWISTGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

AI is not as new as we think, says Gary Rivlin, author of *AI Valley: Microsoft, Google, and the Trillion-Dollar Race to Cash in on Artificial Intelligence.* As our non-artificial guest on *The Resonance Test,* Rivlin tells host Barry Briggs that back in the 1950s, it was thought that AI was always right around the corner. There would be a gathering of technologists who said: “Give us 10 years and we'll have this thing largely solved.” Which meant, says Rivlin: “AI was ‘a decade away' for about 70 years.” Rivlin notes that recommendation engines and Google Translate have been operating for a while. “Google Translate has been around since 2015. That's AI, but no one really thinks of it as AI.” However, when ChatGPT strutted onto the scene, it was something else. Rivlin says: “We were talking to it. Suddenly: AI that you could converse with. It's a whole different beast.” The builders of that beast are his topic in *AI Valley.* Rivlin, who was a reporter for *WIRED* in the dot-com days, returns to his old beat to document the onset of the recent, fast-blooming AI spring. He and Briggs, a former CTO at Microsoft IT, bring years of history into the conversation to offer an assessment at this moment of peak AI in Silicon Valley. They talk, for instance, of Reid Hoffman. Briggs says, “He's the exception to the rule of nice guys finish last.” Rivlin zings back, calling Hoffman: “A billionaire you can root for” and adding “this lonely kid who wanted friends created LinkedIn, which connects the world.” Together they remember the dot-com days of irrational exuberance, getting-rich-by-selling-dog-food-online. “The problem was we tend to overestimate the short-term impact of a technology and underestimate the long term,” says Rivlin, adding we're seeing a similar sort of thinking with AI today. The pair reflect on how people used to joke about autocomplete. “I should have started thinking, ‘this could turn into sentences, this could turn into paragraphs, this could turn into dialogue,'” says Briggs. Rivlin notes that agents aren't “trustworthy” yet. He says that if an agent is going to “make material decisions, it really needs to be trustworthy.” In two, five, 10 years from now, “AI agents are going to be central to the work life of many, maybe perhaps most of us.” We trust that you'll be informed and entertained by this episode. Click on! Host: Alison Kotin Engineer: Kyp Pilalas Producer: Ken Gordon

Today's show:Terra's collapse, Powell's pivot, and OpenAI's explosive growth all collide in this TWiST deep dive.Do Kwon has pled guilty after Terra/Luna's $60B implosion, Fed Chair Powell hints at a September rate cut, and OpenAI has officially crossed $1B in monthly revenue (on a $12B run rate). Jason and Alex unpack what this means for founders, LPs, and the next wave of AI + crypto.They also cover Canva's $42B comeback, Anthropic's doubled $10B fundraise, and the brewing battle between Figma & Canva.Plus: Uber, Nuro & Lucid's $6B robotaxi push — and why drivers are already protesting in Wuhan & Boston.#Startups #Crypto #AI #VentureCapital #OpenAI #Anthropic #Canva #Figma #ThisWeekInStartupsTimestamps:(0:00) INTRO(01:15) Fed rate cut signals & market reaction(05:36) Jason's $400K in new fund bets(10:25) Miro - Help your teams get great done with Miro. Check out miro.com to find out how!(11:30) Show Continues…(16:22) Do Kwon & the Terra/Luna collapse(20:22) Bolt - Don't be left behind. Build apps quickly without knowing how to code with Bolt.new. Try it free at https://www.bolt.new/twist.(21:23) Show Continues…(29:43) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twist(30:55) Show Continues…(36:14) OpenAI's $1B/month revenue run rate(42:13) Anthropic's $10B round & AI market sizing(51:31) Canva's $42B valuation & Figma comparisonSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:25) Miro - Help your teams get great done with Miro. Check out miro.com to find out how!(20:22) Bolt - Don't be left behind. Build apps quickly without knowing how to code with Bolt.new. Try it free at https://www.bolt.new/twist.(29:43) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Whether you're building a new product from scratch, growing your team, or trying to find product market fit, every part of scaling a business has one thing in common. It needs to be well designed. That's why we're headed back to school this week – and learning from Stanford d.school executive director Sarah Stein Greenberg. She reveals strategies for using human-centered design to improve everything from your product roadmap to your company culture.Greenberg's book: Creative Acts for Curious PeopleSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (use code TIM at checkout for one month off on their annual plan)Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off on all mattress orders)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:05:30] How do you solve a problem like presbyopia?[00:08:34] The athletic benefits of training supranormal (better than 20/20) vision.[00:11:49] Indigenous eye drops and FDA-approved pilocarpine for presbyopia.[00:14:05] Understanding basic eye anatomy.[00:17:27] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision.[00:23:00] Visual training devices and psychedelic-prompted brain plasticity.[00:25:12] Thoughts on visual training effectiveness and motor action requirements.[00:28:29] Concussion rehabilitation and visual perception exercises.[00:32:36] Red light and violet light therapy for myopia and mitochondrial health.[00:36:07] Vision loss correlation with cognitive decline and depression.[00:39:36] Presbyopia progression and psychological dependence on readers.[00:41:15] Cognito Therapeutics headset for Alzheimer's treatment.[00:46:46] Glaucoma basics: neurodegenerative disease and risk factors.[00:48:53] Eye pressure variability and diurnal cycles.[00:50:02] Cannabis effects on eye pressure and compound isolation.[00:51:47] Stem cell research for vision restoration.[00:53:09] Anti-inflammatory effects and immune system role in eye diseases.[00:55:15] Gut microbiome connection to glaucoma in animal models.[00:58:43] Metabolic syndrome and GLP-1 receptor agonists.[01:00:50] Microbiome sharing and future therapeutic possibilities.[01:03:31] Dry eye treatment: preservative-free tears and serum drops.[01:08:43] Vision screening recommendations and UV protection.[01:11:22] Full-spectrum light benefits vs. UV exposure.[01:13:27] Paradigm shifts: irreversible vision loss becoming reversible.[01:17:18] Convergence of neuroscience advances and biotech investment.[01:21:58] Miraculous mitochondria: health, transplants, and three-parent babies.[01:26:24] My family history concerns and metabolic health screening.[01:29:26] Exercise's biggest gain: going from none to some.[01:33:03] Clinical trial participation resources and parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:In this TWiST 500 double feature, Alex sits down with two breakout founders: Chalk's Marc Freed-Finnegan & Tollbit's Toshit Panigrahi!First, Chalk's CEO Marc Freed-Finnegan is tackling one of AI's biggest bottlenecks—data freshness. Instead of relying on stale batch jobs, Chalk delivers real-time pipelines for inference compute, automatically transpiling Python into C++/Rust so it can run blazing fast in production. Investors are calling it the ‘next Databricks'—and after hearing this convo, you'll see why.Then, Tollbit's CEO Toshit Panigrahi returns after raising a $24M Series A and signing up 1,400+ publishers. With RAG traffic exploding and robots.txt losing its teeth, their ‘bot paywall' could reshape how AI agents pay for the content they consume. Are we heading for a Spotify moment for data licensing?A must-watch if you care about the economics of AI, from data pipelines to publisher monetization.Timestamps:(0:00) Intro + sponsors(1:03) Alex tees up two Twist 500 interviews: Chalk & Tolbert(2:47) Why AI is shifting from training compute to inference compute(4:41) Data freshness & real-time inference explained(10:43) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(12:00) How Chalk transpiles Python into C++/Rust for speed(18:52) Chalk's business model, margins & $500M valuation(20:11) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(21:24) Show Continues…(28:02) Tollbit returns: $24M Series A & the rise of RAG bot traffic(30:37) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(31:41) Show Continues…(36:53) Robots.txt losing relevance & the case for bot paywalls(39:19)Publishers, AI agents & the future economics of the webSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:43) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(20:11) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(30:37) .TECH: Say it without saying it. Head to get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

A veteran Pulitzer Prize-winning journalist shadows the top thinkers in the field of Artificial Intelligence, introducing the breakthroughs and developments that will change the way we live and work. Artificial Intelligence has been “just around the corner” for decades, continually disappointing those who long believed in its potential. But now, with the emergence and growing use of ChatGPT, Gemini, and a rapidly multiplying number of other AI tools, many are wondering: Has AI's moment finally arrived? In AI Valley: Microsoft, Google, and the Trillion-Dollar Race to Cash In on Artificial Intelligence (Harper Collins, 2025), Pulitzer Prize-winning journalist Gary Rivlin brings us deep into the world of AI development in Silicon Valley. Over the course of more than a year, Rivlin closely follows founders and venture capitalists trying to capitalize on this AI moment. That includes LinkedIn founder Reid Hoffman, the legendary investor whom the Wall Street Journal once called, “the most connected person in Silicon Valley.” Through Hoffman, Rivlin is granted access to a number of companies on the cutting-edge of AI research, such as Inflection AI, the company Hoffman cofounded in 2022, and OpenAI, the San Francisco-based startup that sparked it all with its release at the end of that year of ChatGPT. In addition to Hoffman, Rivlin introduces us to other AI experts, including OpenAI cofounder Sam Altman and Mustafa Suleyman, the co-founder of DeepMind, an early AI startup that Google bought for $650 million in 2014. Rivlin also brings readers inside Microsoft, Meta, Google and other tech giants scrambling to keep pace. On this vast frontier, no one knows which of these companies will hit it big–or which will flame out spectacularly. In this riveting narrative marbled with familiar names such as Musk, Zuckerberg, and Gates, Rivlin chronicles breakthroughs as they happen, giving us a deep understanding of what's around the corner in AI development. An adventure story full of drama and unforgettable personalities, AI Valley promises to be the definitive story for anyone seeking to understand the latest phase of world-changing discoveries and the minds behind them. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

As young people report feeling lonelier and less connected than ever, the dating app Hinge is driving its users into real life, human experiences. CEO Justin McLeod returns to Rapid Response to share how the platform is combating digital fatigue amongst users, as well as navigating the risks and opportunities of AI in online dating. McLeod also explores Hinge's recent collaboration with renowned psychologist Esther Perel, and offers insider tips to find that special someone in the chaos of modern romance. Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:We're back with two insightful new TWiST founder interviews.First up: Dean Leitersdorf of Decart tells us about squeezing maximum productivity out of your GPUs. But it's not all talk: he also shows us the incredible open world model that can magically transform live footage.THEN! Jason and Alex chat with Syncere AI founder Aaron Tan about Lume, his robotic lamp device that went viral for folding laundry. Hear why Aaron thinks the future of robotics is not necessarily humanoid, and all about his future plans for the Lume arms.Timestamps:(0:00) Alex introduces our TwiST 500 interviews(02:27) TWiST 500 Interview #1: Dean Leitersdorf, CEO and Founder of Decart(04:37) Setting out to build a “kilo-corn,” a trillion dollar company(06:27) How making AI much faster opens up a world of new opportunities(09:48) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at https://www.openphone.com/twist⁠(11:00) Why Dean thinks chatbots are the interface of the future(17:24) How Decart builds and trains its models more efficiently (and for less money)(20:01) Netsuite - Download the ebook CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(21:14) Show Continues…(24:36) Interview #2: Aaron Tan of Syncere AI(25:13) Behind-the-scenes of that viral Lume “robot lamp folding laundry” video(30:23) Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on stripe.com/startups.(31:25) Moving beyond laundry: what else these Lume robots do?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(09:48) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at https://www.openphone.com/twist⁠(20:01) Netsuite - Download the ebook CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist(30:23) Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on stripe.com/startups.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

You've tried everything — the habits, the routines, the resets. But the patterns keep coming back. This episode breaks down why intensity won't get you there — and how to shift with integration instead.You've tried all the right things — early wakeups, new planners, strict morning routines — only to find yourself burned out, frustrated, and falling back into old patterns. In this episode, Julie Holly breaks down the root of sustainable change: integration over intensity.You'll learn how your nervous system, neuroplasticity, and spiritual grounding all play a role in rewiring your life at the identity level. Plus, the story of Reid Hoffman's pivot from chaos at PayPal to calibrated consistency at LinkedIn.We'll link prior episodes for deeper context in the show notes.What We Cover in This Episode:• Why your brain resists rigid habit plans• How over-optimization sabotages long-term growth• What Reid Hoffman learned from the early PayPal chaos• How neuroplasticity works under conditions of safety• The spiritual foundation for integration (Phil. 1:6, NLT)• Vagal tone and why your nervous system needs margin• The difference between short-term sprints and sustainable pace• How to move beyond intensity and embrace integrationToday's Micro-Recalibration:Pick one default response you uncovered in Episode 31 or 32.Ask:• Where does this response show up most often?• What would pausing for 5 seconds look like?• How can I integrate a new response gently — not perfectly?You're not behind. You're becoming.If this episode gave you language you've been missing, please rate and review the show so more high-capacity humans can find it. Explore Identity-Level Recalibration→ Follow Julie Holly on LinkedIn for more recalibration insights → Schedule a conversation with Julie to see if The Recalibration is a fit for you → Download the Misalignment Audit → Subscribe to the weekly newsletter → Join the waitlist for the next Recalibration cohort This isn't therapy. This isn't coaching. This is identity recalibration — and it changes everything.

As we gear up for our 2025 Masters of Scale Summit, we're revisiting one of the stellar on-stage conversations that happened at the 2024 event. Hear Rocket Companies' Dan Gilbert and Detroit Mayor Mike Duggan reveal how their unique public-private partnerships have transformed the struggling city into a growing hub for everything from tech companies to electric vehicle manufacturing. Note: this conversation was recorded in October of 2024, before Duggan announced he would not seek another term as mayor and is instead running for governor of Michigan as an independent.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Our guests this week: Adam Brotman and Andy Sack, co-authors of the book AI First: The Playbook for a Future-Proof Business and Brand. Brotman was Starbucks’ chief digital officer and later co-CEO of J.Crew. Sack is a founder, investor, and longtime advisor to tech leaders. Together, they run Forum3, a company that helps brands rethink loyalty and customer engagement. For their book, they interviewed experts including Bill Gates, Sam Altman, Reid Hoffman and Ethan Mollick, and spent time with companies that have had early success with AI implementation. We talk about their "holy-shit" moment with Sam Altman, how Moderna achieved 80% employee participation through AI contests, the CEO who supercharged sales by using AI to analyze call transcripts, and what leaders should actually be doing to roll out AI within their organizations. With GeekWire co-founder Todd Bishop.See omnystudio.com/listener for privacy information.

It's a Friday TWiST and Jason and Alex are FIRED UP about this internal Meta doc laying out appropriate vs. inappropriate AI behavior… You won't BELIEVE with what Zuck approves for 8-year-old users.PLUS… AI job displacement is HERE, at least in the Big Apple… Jason's getting kind of paranoid about the surveillance state… AI remains frothier than ever through new Cohere and Cognition rounds… and why we're dubious that Sam Altman REALLY plans to spend $1 trillion on OpenAI data centers.It's all happening on a brand-new This Week in Startups. Give it a click!Timestamps:(0:00) Intro - How Opendoor became a meme stock(06:58) When companies have less value than cash on hand… what gives?(10:23) - (11:24) Bolt - Don't be left behind. Build apps quickly without knowing how to code with Bolt.new. Try it free at https://www.bolt.new/twist(19:13) New York's not adding jobs… Jason and Alex dig in and offer some theories.(20:25) - (21:30) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(26:56) AI job displacement is HERE and it's happening, folks…(30:05) Why Jason predicts unemployment will be 20% higher 1 year from today… add it to the TWiST Calendar(30:24) - (31:37) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twist(33:02) Wait, Meta AI is having “sensual” chats with children? WHY?(40:00) Will there be fallout to the Meta exposé? Legal? Staffing? Otherwise?(47:47) AI remains frothier than ever with new Cohere and Cognition rounds.(52:33) Sam Altman says he's going to spend $1 trillion on data centers… Jason's dubious.Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:23) Bolt - Don't be left behind. Build apps quickly without knowing how to code with Bolt.new. Try it free at https://www.bolt.new/twist(20:25) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(30:24) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

From humble beginnings selling vacuums on late night informercials, SharkNinja has grown to a 6 billion dollar a year business. CEO Mark Barrocas joins host Jeff Berman to reveal how the company keeps coming up with hits like the Ninja Creami, why “educated consumers” are the backbone of their business, and how they're navigating the shifting winds of tariffs.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:We're back with another all-star VC roundtable discussion.Joining Jason are Dave McClure of Practical VC, NVNG's Grady Buchanan, and Tomasz Tunguz of Theory VC. Together, they're having a deep insider discussion of the state of venture, secondary markets, running funds of funds, the legacy of Lina Khan, the difficulty of recruiting, and why the pendulum has potentially swung in founders' favor.Timestamps(0:00) INTRO, The origins of Practical VC and how secondary funds work.(05:44) So… how does Dave decide what to BUY?(09:27) Melanie - Companies are staying private longer… Is this good for fund managers?(10:02) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(11:18) Show Continues…(14:17) We've all heard about unicorns but… what about centaurs?!(16:19) Jacob - Are VC marks… bullsh*t?! How long until your LPs should see DPI? The panel debates.(17:22) Jacob - Is Jason too hard on Lina Khan? Dave says VCs created the problem!(20:07) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(21:30) Show Continues…(30:01) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.(31:16) Show Continues…(31:34) When it's time to embed an expert into a struggling startup(34:15) How investing in SO MANY COMPANIES gave Dave a trove of data(40:33) Sometimes VCs have to be the “voice of reality”…(45:53) Are stock buybacks the best use of capital?(49:29) Jacob - The End of the ZIRP Era meets the Dawn of the AI Era(51:04) Why running your business on debt, not equity, requires tough choices(58:23) When you need to “take the medicine” on returns and live to fight another day.(01:11:17) Is Grady actively seeking managers that have shown a demonstrated ability to produce liquidity?(01:13:24) Dave says the pendulum has swung into founders' favor.(01:20:25) Dave teases his new secondary podcast, “Trading Places”!Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:02) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST(20:07) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits(30:01) Public - Take your investing to the next level with Public. Build a multi-asset portfolio and earn 4.1% APY on your cash—with no fees or minimums. Start now at public.com/twist.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Zoom out from continuing tariff turmoil and Trump's recent attacks on the Fed and the Bureau of Labor Statistics, and you'll see a broader new economic order is forming. Political economist and Brown University professor Mark Blyth joins Rapid Response to reveal why outdated models still underpin much of our economic understanding, and what we still misunderstand – and underestimate – about China. Blyth also shares why the Democrats struggle to craft an engaging story about the economy, why it's so hard to predict a recession, and what Brown's recent settlement with the Trump Administration tells us about higher education's need to pivot from its reliance on federal funding.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:On an all-new Monday TWiST, Lon joins Jason and Alex to talk about a whole bunch of stories at the intersection of tech, business, and pop culture.First up, is GPT Psychosis real? And if so, what are the warning signs that your loved ones have been ONESHOTTED.Then, why did Jason get so upset at the NY Times piece about Mark Zuckerberg's Palo Alto compound?PLUS we're discussing Trump's export fees on AMD and Nvidia, Jason's pitch for why the president should work more closely with Congress, a new tool in the search for rare-earth minerals, just how many self-driving trucks are on Chinese roads today, and much much more!Timestamps:(0:00) INTRO, Why Jason hated the NYT story about Mark Zuckerberg's compound.(09:54) Vouched - Trust for agents that's built for builders like you. Check it out at http://vouched.id/twist(11:14) Show continues…(19:54) Coda - Empower your startup with Coda's Team plan for free—get 6 months at https://www.Coda.io/twist(21:01) Show continues…(27:25) GPT Psychosis: Is it real and how widespread is it?(29:13) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist(30:16) Show continues…(45:45) What it means to get “One-Shotted”: is Sam Altman doing this on purpose?(53:56) Jason says working multiple jobs at once is STEALING… is that fair?(01:04:53) Are Trump's Chinese export fees for AMD and Nvidia a justified licensing process? Or a shakedown?(01:09:22) Jason's pitch for working closer with Congress, and why Alex has concerns about clarity(01:12:02) PolyMarket: Will tariffs generate >$250b in 2025?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(09:54) Vouched - Trust for agents that's built for builders like you. Check it out at http://vouched.id/twist(19:54) Coda - Empower your startup with Coda's Team plan for free—get 6 months at https://www.Coda.io/twist(29:13) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twistGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Today's show:Jason and Lon recorded a Thursday night special edition, so no Alex this time, but still lots to talk about.First up, Jason thinks it's time for Tim Apple to exit the stage in lieu of a product obsessive innovator. Speaking of new products, GPT-5 is here and the hosts are… not exactly blown away. Are we in the midst of the AI trough of despair?PLUS we're talking Ripple's acquisition of Rail, Donald Trump's new AI chatbot, Bumble's new direction, Airbnb's potential paths forward and MUCH MUCH MORE.Timestamps:(0:00) Why Jason thinks Apple lacks innovation (plus a look back at his 2019 thoughts)(08:54) Sentry - New users get 3 months free of the Business plan (covers 150k errors). Go to http://sentry.io/twist and use code TWIST(09:54) Show continues…(20:10) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(21:18) Is GPT-5 coming for Lovable and Bolt?(29:42) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at AlphaSense.com/Twist.(30:55) Show continues…(35:05) Ripple buying Rail, and why sometimes regulations are GOOD for companies(43:28) Is Ripple about to become the MicroStrategy of XRP?(47:48) Truth Social AI is perplexing, powered by Perplexity(53:27) Should people be using ChatGPT for therapy? What do you think? How does that make you feel?(01:04:42) Anthropic's Dario Amodei recalls his greatest haters(01:11:04) Bumble but… for friendship?(01:12:20) DoorDash's crazy growth, and the guys discuss who should buy AirbnbSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(08:54) Sentry - New users get 3 months free of the Business plan (covers 150k errors). Go to http://sentry.io/twist and use code TWIST(20:10) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(29:42) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at AlphaSense.com/Twist.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

When Rick Shadyac Jr. took over as CEO of the fundraising organization responsible for St. Jude Children's Research Hospital, it was bringing in about 600 million a year. The recently retired leader joins host Jeff Berman to reveal how he built a fundraising machine that is now approaching 3 billion per year, and how that money will have a global impact on kids with cancer. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's show:It's a brand-new PACKED episode of TWiST. Jason and Alex welcome guest Zach Dive of Adam.new, to tell us why he made a deepfake AI ad starring Jason and the All-In besties.PLUS a rundown of the biggest tech and startup news of the day, including Disney's decision to sunset Hulu, OpenAI's new open-weight models, the Cloudflare vs. Perplexity feud, Uber's newly-announced stock buyback, China's Luckin Coffee coming to Manhattan, and much much more!Timestamps:(0:00) Luckin Coffee hits NYC… along with COMMUNISM?!(09:15) Is China taking on major American brands on PURPOSE?(10:16) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(11:29) Show Continues…(20:17) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech(21:30) Show Continues…(26:02) RIP HULU: Why Disney is sunsetting the iconic app.(28:37) Nostracanis Returns: Jason's 2017 Disney vs. Netflix predictions came true(30:24) .TECH - Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.(31:28) Show Continues…(35:39) Zach Dive of Adam.new joins to tell us about making a viral deepfake ad starring JCal and the Besties(44:10) Zach shares thoughts on AI and copyright, and why it's a problem for the “big dogs,” not him… yet(48:12) Jason wants to wet his beak… but is there room in the Adam.new seed round?(53:07)OpenAI's new models are open-WEIGHT; how that's different from open-source.(58:36) Do Nvidia and Apple devices NEED kill switches and backdoors? Why it's such a tough question.(01:02:10) GPT-5 arrives TOMORROW?!(01:03:31) Cloudflare vs. Perplexity… let them fight?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:16) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(20:17) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech(30:24) .TECH - Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

This is a very special episode for me. My brand-new card game, COYOTE, created in collaboration with Elan Lee and Exploding Kittens, is here. It is available in ~8,000 locations worldwide, including Walmart, Target, Amazon, and many others. Learn more: https://coyotegame.com.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (use code TIM at checkout for one month off on their annual plan) Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps (will be updated): 00:00 Intro 05:21 The Journey to Creating a Game05:51 The Creative Process Behind Coyote17:16 The Importance of Constraints in Creativity35:04 The Toronto Sprint41:02 The Evolution of Coyote: From Concept to Prototype47:36 Game Design Principles and Recommendations51:53 Introduction to 'Don't Shoot the Dog'53:25 Simplifying Game Design58:55 Playtesting and Iteration01:08:10 Finding the Sweet Spot in Game Difficulty01:14:35 The Success of 'Hurry Up Chicken Butt'01:22:26 Testing and Feedback Process01:34:49 Pitching to Big Retailers01:36:19 Designing the Perfect Game Box01:36:31 Testing and Validating Game Designs01:41:23 The Road to Retail Success01:43:51 Keys to a Successful Line Review01:44:29 The Role of Agents and Publishers02:07:56 Crowdfunding and Self-Publishing02:19:56 Understanding Game Publishing Deals02:27:40 Common Pitfalls in Game Packaging and Marketing02:38:39 Navigating Retail and Distribution Challenges02:47:25 Final Thoughts and a Tantalizing Offer*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

As the Trump Administration ramps up mass deportations, the American Business Immigration Coalition is advocating for policy reform. Rebecca Shi leads the organization made up of 1,400 current and former CEOs, trade group leaders and more, who heavily rely on an immigrant workforce. Hear how uncertainty over immigration has disrupted daily business and hit the bottom line, as well as the carve-outs and clarity that big employers like Lowe's, Tyson Foods and others seek for the long-term.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.