Podcasts about controlling blood sugar

Welcome back to The Wellfuel Podcast! In this episode, our very own Sydney Flippo, RDN discusses how to eat for blood sugar management. Did you know that healthy blood glucose levels are largely within our control through lifestyle choices such as diet, exercise, sleep, and stress management? Sydney will be highlighting the importance of nutrient-dense foods and making recommendations to improve the digestion of these foods. Additionally, Sydney will discuss the role of exercise in regulating blood sugar and the impact of sleep and stress on glucose levels.  Chapters 00:00  Introduction and Importance of Blood Sugar Management 01:26  Controlling Blood Sugar with Nutrient Dense Foods 03:19  Carbohydrates as Accompaniment to Meals 04:09  Order and Timing of Food Consumption 05:33  Exercise for Blood Sugar Regulation 07:30  Sleep and Stress Management for Blood Sugar Control 09:22  Simple Steps to Manage Blood Glucose If you loved this episode, leave us a review - it really helps! See you next week! ---------------------------- Want to learn more about how Isabel Smith Nutrition can help support your quest for better blood sugar management?  Book a call with us today! ------------------------- Join us next week for a NEW episode of The Wellfuel Podcast! Be sure to like, share, and subscribe to The Wellfuel Podcast for more great nutritional content in the future! You can learn more about Isabel Smith Nutrition by following us on Instagram: @isabelsmithnutrition Isabel Smith, MS, RD, CDN

***JOIN THE MASTER YOUR FASTING CHALLENGE THAT STARTS Sept 13TH, 2023! New to fasting or want to get back on track? Struggling to break through a plateau? Ready to finally stop obsessing about your diet? Let's kick off back to school and the end of summer with intention, habit-building, and fast-tracking your fasting results! We'll teach you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! Join us on Sept 13th for the Master Your Fasting Challenge!  REGISTER HERE! Click the Link for DATES, DETAILS, and FAQ!  Sept 13th CHALLENGE REGISTRATION LINK   Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here!   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy explores a balanced perspective on carbohydrates, emphasizing moderation and choosing the right sources. They advise reducing sugars, refined grains, and liquid carbs while opting for minimally processed carbs from vegetables and fruits. Strategies like aligning carb intake with individual responses, leveraging "fasting optimizers," and selecting appropriate carb swaps are presented.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount  - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGFORLIFE” www.nutrisense.io/fastingforlife Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here!   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them  

***JOIN THE MASTER YOUR FASTING CHALLENGE THAT STARTS Sept 13TH, 2023! New to fasting or want to get back on track? Struggling to break through a plateau? Ready to finally stop obsessing about your diet? Let's kick off back to school and the end of summer with intention, habit-building, and fast-tracking your fasting results! We'll teach you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! Join us on Sept 13th for the Master Your Fasting Challenge!  REGISTER HERE! Click the Link for DATES, DETAILS, and FAQ!  Sept 13th CHALLENGE REGISTRATION LINK Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here!   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy discuss the relevance of blood sugar for individuals without diabetes. How blood sugar levels affect energy, weight, hormones, mood, and long-term health, and emphasize the importance of addressing blood sugar issues early. They share insights about the impacts of intentional blood sugar spikes on cravings and overall well-being.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount  - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGFORLIFE” www.nutrisense.io/fastingforlife Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here!   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them  

Today, I am blessed to have here with me Dr. David Perlmutter, a Board-Certified Neurologist, and six-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer's Disease. He has published extensively in peer-reviewed scientific journals, including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.  In addition, he is a frequent lecturer at symposia sponsored by institutions such as the World Bank and IMF, Columbia University, Scripps Institute, New York University, and Harvard University. He serves as an Associate Professor at the University of Miami Miller School of Medicine. His books have been published in 32 languages and include the #1 New York Times bestseller Grain Brain, The Surprising Truth About Wheat, Carbs, and Sugar, with over 1 million copies in print. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan, and Brain Wash, co-written with Austin Perlmutter, M.D. He is the editor of The Microbiome and the Brain, authored by top experts in the field and published in December 2019 by CRC Press. His latest book, Drop Acid, focused on the pivotal role of uric acid in metabolic diseases and was published in February 2022. In this episode, Dr. Perlmutter speaks about the inspiration behind his career in the gut, brain health, and uric acid. We dive into Dr. Perlmutter's latest book, Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health. He explains why high uric acid levels are dangerous to your health and what you can do to fix them. Tune in as we chat about tart cherries, coffee, and how poor stress management can lead to higher uric acid levels.  Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. EveryDay Dose Everything you love about coffee, none of what you don't — say goodbye to jitters, anxiety, crash, and digestive issues. https://everydaydose.superfiliate.com/KETOKAMP  (5 FREE Travel Packs + Free Frother applied) Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [00:50] Why Dr. Perlmutter Dedicated His Life To The Gut, The Brain, and Uric Acid Dr. Perlmutter wanted to work to create programs that would help patients prevent the very diseases that they were trying to treat.  Lifestyle choices really play a central role as we architect our brain's future.  So, Dr. Perlmutter began to implement lifestyle medicine into his practice.  Eventually, Dr. Perlmutter wrote Grain Brain to help people understand that lifestyle choices significantly impact our brain's destiny.  Get Grain Brain here: https://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/0316485136/benazadi-20 After Grain Brain, Dr. Perlmutter started to study how the gut influences the brain's destiny.  Lately, Dr. Perlmutter has been studying how uric acid disturbs our metabolism.  [15:00] Why Dr. Perlmutter Decided To Write A Book All About Uric Acid Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health: https://www.amazon.com/Drop-Acid-Surprising-Controlling-Extraordinary/dp/0316315397/benazadi-20 The average rate of uric acid in America right now is six. People with high uric acid levels have an increased risk of dementia and Alzheimer's.  There's a relationship between these diseases and uric acid.  Uric acid directly leads to insulin resistance.  [19:30] Your Body Is Retaining Uric Acid As A Survival Mechanism   We tend to retain uric acid. Our uric acid levels can be higher as a survival mechanism, thanks to our primate ancestors. We don't hibernate for six months. Therefore, we don't need to be storing this fat for the winter that never comes.  88% of American adults are metabolically unhealthy. Getting Covid is associated with a 40 to 60% increased risk of type two diabetes. Individuals with higher uric acid levels have a higher risk of dying from Covid.  [25:10] Your Body Can't Handle More Than Five Grams of Fructose At A Time Your body can handle some fructose, about five grams at a time.  When your body is presented with high levels of fructose, it overwhelms what the body can do.  When fructose is delivered in the context of fiber, it slows the absorption. So, it's better to eat an apple than drink apple juice.  Vitamin C aids in uric acid excretion.  The most common way to overdo fructose consumption is by drinking fruit juice.  A 12-ounce glass of orange juice might have 30 grams of sugar. There's no way the body will be able to deal with that appropriately.  [35:30] Tart Cherries As A Remedy For Gout and Lowering Uric Acid Levels  Tart cherries have been researched for decades. Originally, tart cherries have been looked upon as a remedy for gout.  It has been noted that people who ate cherries would have fewer gout flare-ups.  Tart cherries are pretty darn effective in lowering uric acid levels.  [36:40] The Health Benefits of Drinking Coffee  Drinking coffee is associated with a dramatically lowered risk of Alzheimer's. Coffee is also associated with lower uric acid levels.  Plus, coffee reduces inflammation, upregulates antioxidant function, and improves detoxification in the body.  Also, coffee helps us grow new brain cells, no matter our age.  [41:45] The Relationship Between Animal-Based Protein and The Role of Uric Acid Fiber is so essential for human health. Most of Dr. Perlmutter's food is plant-based.  Regarding our uric acid story, certain meats or animal products are worse than others. Organ meats, sardines, anchovies, and scallops can raise your uric acid levels.  The most significant issues for uric acid are fructose, purines, and alcohol.  [48:20] Should I Follow A Ketogenic Lifestyle If I Have Gout Attacks?  The most significant player in gout is fructose.  When you research how to fix gout, there will be no talk about removing sugar or fructose from your diet.  The human requirement for sugar in our diets is zero grams per day.  We subsidize the growth of corn from which high fructose corn syrup comes from. We are supporting the diseases that are sucking up our healthcare resources. Diseases are significant money makers for the healthcare industry.  It's time we start thinking about prevention.  [52:25] What Role Does Mental-Emotional Stress Play With Uric Acid Levels? When we are experiencing stress, our ability to make rational, forward-thinking decisions is compromised. When your decision-making is compromised, you won't be making good lifestyle choices.  Therefore, under stress, you will eat more foods that have sugar.  Eventually, you will raise uric acid levels and feed the flame of poor metabolic health. It is time to make better decisions by lowering your stress levels.  AND MUCH MORE!   Resources from this episode:  Check out Dr. David Perlmutter's Website: https://www.drperlmutter.com/ Follow Dr. Perlmutter  Facebook: https://www.facebook.com/DavidPerlmutterMd Twitter: https://twitter.com/davidperlmutter YouTube: https://www.youtube.com/user/DavidPerlmutterMD Instagram: https://www.instagram.com/davidperlmutter/ Get Dr. Perlmutter's Books: https://www.drperlmutter.com/learn/books/ Grain Brain: https://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/0316485136/benazadi-20 Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health: Uric Acid testing device: https://amzn.to/3yjeP8Q https://www.amazon.com/Drop-Acid-Surprising-Controlling-Extraordinary/dp/0316315397/benazadi-20 Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. EveryDay Dose Everything you love about coffee, none of what you don't — say goodbye to jitters, anxiety, crash, and digestive issues. https://everydaydose.superfiliate.com/KETOKAMP  (5 FREE Travel Packs + Free Frother applied) Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Walking off weight – in far less time than you might think – not only sounds easier and more accessible than most exercise options, but also been proven. Move over intermittent fasting, here comes intermittent walking.  Seriously, I don't mean to dish fasting. And plenty of prior episodes have reviewed the plausibility of fasting based on when and how as well as your status. A recent study published in the Journal of Sports Medicine found that intermittent walking throughout the day reduced post-prandial (that is, after meal) glucose by 17%. More on this in a minute. Intermittent standing didn't have the same effect, but it was good. That improved glucose by 9%. So, your stand-up desk may indeed be beneficial for posture and energy, and for benefits on those days you can't walk, but it is the walking that offers the best benefit. Spikes in blood sugar after a meal, or drinks, are normal. But too great a spike and too frequently increases inflammation. A big point to clarify though that this benefit comes not from walking after a meal. The benefit to post meal glucose was made on intermittent walking throughout the day. You, like many, will find this provides a lot of latitude to be successful. Having to walk 10 minutes after a meal, during the workday for instance, isn't always possible if you've got a short time for lunch anyway, have to drive to do it, or you're shortchanging yourself on lunch at all. Walking Off Weight in Menopause Women in menopause may already be more prone to negative effects of stress due to hormonal and metabolic changes. That can impact the rise in inflammation's negative effects. There's no question that breaking up sedentary periods with standing is better than continuous sitting. There's also the very clear bigger benefit when that is light walking. That could be 2 minutes of marching in place, walking down the hall or to the next floor in your building and back. Turn on the music and dance like no one, or everyone you love - is watching because they might catch it!! I want to repeat this. The intermittent movement during the day, decreased the spike in glucose after meals, even when the activity wasn't at mealtime or after it. It reduced glucose levels by as much as 17%. Now, you want amplify results? Walk after meals. Within 30 minutes of a meal, walk for 10 minutes. That reduced glucose levels by 22%. Your goal is to walk soon after a meal when that post-meal spike is high. How Does this Compare to Strength Training? Given strength training is recommended as a treatment for Type 2 Diabetes, it is fair to say, strength training decreases risk by improving glucose levels as well. In a study of type 2 diabetics intense resistance training trumped more frequent lighter resistance training. Skeletal muscle is the major tissue associated with glucose uptake. When you lose that, and particularly during menopause transition if you weren't lifting or aren't yet, where accelerated losses can easily occur, risk of pre-diabetes or what's known as insulin resistance can occur. Walking will stimulate muscle tissue but will do little to increase or even maintain that muscle tissue. But the news is good no matter who you are or where you lie on the continuum of activity. So, whether you're barely active, and begin two minutes of movement several times a day, or start walking after meals, or decide you're going to give strength training a try, your time commitment is relatively small. The return on investment may support with energy today and a stronger longer future. Even on the couch, move the body parts you can. Substitute “walking” for moving your arms, swaying in your chair, supporting yourself and moving feet side to side. It is the movement of body parts that counts. Not started yet? This is a fantastic place to get started and be notified when our next 12-week program opens too.   References: https://link.springer.com/article/10.1007/s40279-022-01649-4 https://pubmed.ncbi.nlm.nih.gov/18781481/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267507/ https://link.springer.com/article/10.1007/s00125-016-4085-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446383/ Resources: Last Day for Food Flip: https://www.flippingfifty.com/food-flip CBM: https://www.flippingfifty.com/glucose Additional Episodes You May Like: Intermittent Fasting for Women: https://www.flippingfifty.com/intermittent-fasting-for-women/ Midlife Weight Loss for Women: https://www.flippingfifty.com/midlife-weight-loss/ The Missing Link to Weight Loss: https://www.flippingfifty.com/weight-loss-for-women/    

This episode is brought to you by InsideTracker and Gut Food.Researchers around the globe over the past decade have discovered that uric acid, previously thought of only in terms of gout, actually plays a central role in metabolic disorders. So, how is uric acid orchestrating this metabolic mayhem?On today's mini-episode, Dhru sits down with Dr. David Perlmutter to talk about how uric acid plays a major role in fat storage, insulin resistance, and other metabolic and chronic degenerative diseases that are driving illness and death in our country.Dr. Perlmutter is a board-certified neurologist and five-time New York Times bestselling author. He received an MD from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the editorial board for the Journal of Alzheimer's Disease and has published extensively in peer-reviewed scientific journals. He also serves on the board of directors and is a Fellow of the American College of Nutrition. In this episode we dive into:-Surprising foods that drive uric acid levels -How elevated uric acid levels directly lead to increased fat storage -The consequences of elevated uric acid -The main culprits that lead to elevated uric acid levels -How to test uric acid levels and what the optimal range is-The relationship between elevated uric acid and the risk of heart disease and Alzheimer's Listen to the full episode here.For more on Dr. Perlmutter, follow him on Instagram @davidperlmutter, Facebook @davidperlmuttermd, Twitter @davidperlmutter, YouTube @davidperlmuttermd, and through his website, drperlmutter.com. Get his book Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health, here.This episode is brought to you by InsideTracker and Gut Food.InsideTracker provides detailed nutrition and lifestyle guidance based on your individual needs. Right now, they're offering my podcast community 20% off. Just go to insidetracker.com/DHRU to get your discount and try it out for yourself.Gut Food uses the power of three critical gut-supporting components—prebiotics, probiotics, and polyphenols—and five ingredients at clinically validated dosages to help reduce inflammation, support the growth of beneficial gut bacteria, improve digestion and bloating, and support mood and energy. Check it out at gutfood.com. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Welcome to this episode of The Tonic, terrestrially broadcast on July 23 and 24, 2022 on AM740 and FM 96.7 in Toronto. Topics covered on the show track the lifestyle articles and themes published in Tonic Magazine. This week we discuss how to control blood sugar naturally with Joel Thuna, forgiveness with Hina Khan, yoga for seniors with Emily Sann,

As a child, Dr. David Perlmutter developed an uncommon familiarity with the human brain. Exploring the surgical ward -- and eventually, the operating room -- with his neurosurgeon dad, he observed the possibilities of modern brain medicine, but also its limits. After becoming a neurologist himself, he grew dissatisfied with the medical status quo which he says tended to react to brain diseases like Alzheimer's after they took effect. The numerous bestselling books he has since written draw on the latest science to explain how the brain interacts with the rest of the body and give readers the tools to adapt accordingly. The latest example is Drop Acid: The Surprising New Science of Uric Acid - The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health. Dr. Perlmutter's work reflects a commitment to questioning the scientific status-quo. “I'm not saying to be iconoclastic day in and day out,” he tells host Shiv Gaglani. But he wants to “look at long-held tenants and recognize that nothing is sacrosanct. There's nothing there that can't be overturned.” Tune in to learn about a powerful new tool in everyone's toolkit for keeping our brains healthy, and how doctors can get patients to actually follow through on their lifestyle recommendations. Mentioned in this episode: https://www.drperlmutter.com/

What is the best approach for treating and preventing Alzheimer's Disease? After my traumatic brain injury, my grandmother became my primary caregiver because my parents had to work multiple jobs. From a young age, I watched her struggle with Alzheimer's, and I saw firsthand how devastating this disease is. It's why I'm so passionate about brain health and work with leading experts in their mission to understand, treat, and prevent Alzheimer's and other brain diseases. To talk more about this very important topic, I'm delighted to have Dr. David Perlmutter back on our show today. Dr. Perlmutter is an MD board-certified neurologist and five-time New York Times best-selling author, including his latest, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health. When you lose your memory, it can feel like you're losing a part of yourself. But instead of feeling helpless, I want you to feel empowered to make small changes that can have a long-term impact on your brain and body health. Listen in, as Dr. Perlmutter talks about understanding the role uric acid and inflammation plays in your body and how that impacts the progression of diseases like Alzheimer's. *** Do you want to stay up to date with every new episode and get my brand new Kwik Brain Accelerator Program? Go to www.KwikBrain.com/podcast to get instant access. *** Or text me 310-299-9362 to get your burning questions answered and an insider sneak peek of exciting updates. I do my best to answer as many as I can each day, so shoot me a message today.

This episode is brought to you by ButcherBox and Vivobarefoot.Uric acid is a central player in metabolic mayhem. Despite its long association with gout and kidney stones, it's involved in so much more—especially our metabolic disease epidemic.There are three things that raise our levels of uric acid: purines, alcohol, and fructose. The latter is the biggest challenge, due to its overwhelming presence in our Standard American Diet. That doesn't mean all fruit is bad or even that all alcohol and purine-rich foods have the same effect. Like all parts of health and nutrition, there are nuances we need to consider to create optimal health.Today on The Dhru Purohit Podcast, Dhru talks about uric acid, the role it plays in turning on, or off, our body's fat-storage switch, and how getting it under control can significantly reduce our risk of chronic disease.In this episode, we dive into: -The link between uric acid and metabolic dysfunction-Why our metabolic switch is always turned on-Hidden sources of fructose in our diets-How uric acid levels can tell us a lot about our cardiometabolic health Also mentioned in this episode:-Try This: How To Turn Off Your Fat-Storage Switch-The Latest Science on How to Turn Your Body's Fat-Storage Switch Off with Dr. Richard Johnson-​​Nature Wants Us to Be Fat: The Surprising Science Behind Why We Gain Weight and How We Can Prevent—and Reverse—It-Try This: Smoothie Recipes That Won't Spike Your Blood Sugar-Calculate Your Fructose Intake -Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health-UASure Uric Acid Meter This episode is brought to you by ButcherBox and Vivobarefoot.Right now, ButcherBox is offering new members a great deal. You'll receive two pounds of FREE salmon in your first box. Sign up at ButcherBox.com/dhru.Vivobarefoot footwear is designed to be wide, thin, and flexible—as close to barefoot as possible. They promote your foot's natural strength and movement, allowing you to feel the ground beneath your feet. Vivobarefoot is offering 20% off your first order at vivobarefoot.com/DHRU. See acast.com/privacy for privacy and opt-out information.

Every Wednesday I'm going LIVE on Facebook and IG to talk about metabolic health and weight loss topics. Afterwards you'll have time to ask questions if you're on LIVE with me otherwise tune into the episode after I release it on the podcast.We talk about the perils of URIC acid and why it has such detrimental effects on metabolic health. ✅ We talk about the 3 things that cause uric acid to rise in the body and why the body even raises uric acid in the first place. ✅ We talk about the 5 supplements you can take to lower uric acid✅ We talk about the lifestyle and diet factors that contribute to uric acid

Sign up to Patreon to get access to bonus ad-free podcasts, exclusive downloads, live Q&As and more: https://www.patreon.com/drcarolineleaf EPISODE DESCRIPTION: In this podcast I talk to best-selling author Dr. David Perlmutter about his new book Drop Acid: The Surprising New Science of Uric Acid-The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health, strategies to control uric acid levels in your diet and improve your health, and so much more! Read the show blog here: https://drleaf.com/blogs/news/how-your-uric-acid-levels-could-hold-the-key-to-optimizing-your-mental-physical-health Get the book here: https://www.drperlmutter.com/books/drop-acid/ OFFERS FROM OUR SPONSORS: -Ned: If you'd like to give Ned a try, Cleaning Up The Mental Mess listeners get 15% off Ned products with code: DRLEAF. Just visit helloned.com/DRLEAF to get access! -BiOptimizer's Magnesium Breakthrough: For an exclusive offer for my listeners go to http://www.magbreakthrough.com/leaf and use DRLEAF10 during checkout to save 10% on your order. -Amen Clinics: Visit amenclinics.com/drleaf and use the promo code DRLEAF10 to get 10% off your first evaluation. EPISODE HIGHLIGHTS: 2:40 The relationship between uric acid, metabolism & health 4:40 Why high uric acid levels can be dangerous 6:25 Uric acid is an warning signal we need to pay attention to 7:00 How just changing the way we eat can increase our lifespan 8:00 Why we need to treat the root causes of health issues, not just the symptoms 12:25 Why we have to take agency over our healthy destiny & we can do this with the right information 16:00 What uric acid is & how it affects our metabolism 22:00, 27:00 How to improve uric acid levels through dietary changes 23:00 Why coffee is so great! 30:00 Dr. Perlmutter's recipes to improve uric acid levels 31:50 Supplements that can help support healthy uric acid levels 34:12 Uric acid & mental health ADDITIONAL RESOURCES: -Get my new book Cleaning up Your Mental Mess here: https://www.cleaningupyourmentalmess.com -Download my new and improved brain detox app here: https://neurocycle.app -Get a free Cleaning up Your Mental Mess workbook when you subscribe to my weekly email at drleaf.com! -Sign up to join my free text program and receive mental health care tips. Just text DRLEAF to 1 (833) 285 3747 -Visit my website at https://drleaf.com for more free resources -Instagram: @drcarolineleaf: https://www.instagram.com/drcarolineleaf/- -Facebook: Dr. Caroline Leaf: https://www.facebook.com/drleaf -Twitter: @drcarolineleaf: https://twitter.com/DrCarolineLeaf - Youtube: https://www.youtube.com/drcarolineleaf *DISCLAIMER: This podcast and blog is for educational purposes only and is not intended as medical advice. We always encourage each person to make the decision that seems best for their situation with the guidance of a medical professional.

If you've tried everything to gain control of your health and manage your weight but still feel like you can't reach your goals, I think you'll appreciate today's conversation about Uric Acid.    The scientific literature is bursting with evidence that chronic elevated uric acid lies at the root of many pervasive health conditions, such as obesity, diabetes, cardiovascular disease. But it's not something that's being discussed in  mainstream medicine and media…. Until now.     Today's guest, David Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition.    His groundbreaking book, Grain Brain, showed that the fate of your brain is not in your genes. It's in the food you eat. By the way, that book made it to the top… #1 on the New York Times bestseller list.    David's new book, Drop Acid, alerts us to the dangers of elevated uric acid, and how it's a Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health.   

Today, I am blessed to have here with me Dr. David Perlmutter, a Board-Certified Neurologist, and six-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer's Disease. He has published extensively in peer-reviewed scientific journals, including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.  In addition, he is a frequent lecturer at symposia sponsored by institutions such as the World Bank and IMF, Columbia University, Scripps Institute, New York University, and Harvard University. He serves as an Associate Professor at the University of Miami Miller School of Medicine. His books have been published in 32 languages and include the #1 New York Times bestseller Grain Brain, The Surprising Truth About Wheat, Carbs, and Sugar, with over 1 million copies in print. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan, and Brain Wash, co-written with Austin Perlmutter, M.D. He is the editor of The Microbiome and the Brain, authored by top experts in the field and published in December 2019 by CRC Press. His latest book, Drop Acid, focused on the pivotal role of uric acid in metabolic diseases and was published in February 2022. In this episode, Dr. Perlmutter speaks about the inspiration behind his career in the gut, brain health, and uric acid. We dive into Dr. Perlmutter's latest book, Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health. He explains why high uric acid levels are dangerous to your health and what you can do to fix them. Tune in as we chat about tart cherries, coffee, and how poor stress management can lead to higher uric acid levels.  Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [00:50] Why Dr. Perlmutter Dedicated His Life To The Gut, The Brain, and Uric Acid Dr. Perlmutter wanted to work to create programs that would help patients prevent the very diseases that they were trying to treat.  Lifestyle choices really play a central role as we architect our brain's future.  So, Dr. Perlmutter began to implement lifestyle medicine into his practice.  Eventually, Dr. Perlmutter wrote Grain Brain to help people understand that lifestyle choices significantly impact our brain's destiny.  Get Grain Brain here: https://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/0316485136/benazadi-20 After Grain Brain, Dr. Perlmutter started to study how the gut influences the brain's destiny.  Lately, Dr. Perlmutter has been studying how uric acid disturbs our metabolism.  [15:00] Why Dr. Perlmutter Decided To Write A Book All About Uric Acid Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health: https://www.amazon.com/Drop-Acid-Surprising-Controlling-Extraordinary/dp/0316315397/benazadi-20 The average rate of uric acid in America right now is six. People with high uric acid levels have an increased risk of dementia and Alzheimer's.  There's a relationship between these diseases and uric acid.  Uric acid directly leads to insulin resistance.  [19:30] Your Body Is Retaining Uric Acid As A Survival Mechanism   We tend to retain uric acid. Our uric acid levels can be higher as a survival mechanism, thanks to our primate ancestors. We don't hibernate for six months. Therefore, we don't need to be storing this fat for the winter that never comes.  88% of American adults are metabolically unhealthy. Getting Covid is associated with a 40 to 60% increased risk of type two diabetes. Individuals with higher uric acid levels have a higher risk of dying from Covid.  [25:10] Your Body Can't Handle More Than Five Grams of Fructose At A Time Your body can handle some fructose, about five grams at a time.  When your body is presented with high levels of fructose, it overwhelms what the body can do.  When fructose is delivered in the context of fiber, it slows the absorption. So, it's better to eat an apple than drink apple juice.  Vitamin C aids in uric acid excretion.  The most common way to overdo fructose consumption is by drinking fruit juice.  A 12-ounce glass of orange juice might have 30 grams of sugar. There's no way the body will be able to deal with that appropriately.  [35:30] Tart Cherries As A Remedy For Gout and Lowering Uric Acid Levels  Tart cherries have been researched for decades. Originally, tart cherries have been looked upon as a remedy for gout.  It has been noted that people who ate cherries would have fewer gout flare-ups.  Tart cherries are pretty darn effective in lowering uric acid levels.  [36:40] The Health Benefits of Drinking Coffee  Drinking coffee is associated with a dramatically lowered risk of Alzheimer's. Coffee is also associated with lower uric acid levels.  Plus, coffee reduces inflammation, upregulates antioxidant function, and improves detoxification in the body.  Also, coffee helps us grow new brain cells, no matter our age.  [41:45] The Relationship Between Animal-Based Protein and The Role of Uric Acid Fiber is so essential for human health. Most of Dr. Perlmutter's food is plant-based.  Regarding our uric acid story, certain meats or animal products are worse than others. Organ meats, sardines, anchovies, and scallops can raise your uric acid levels.  The most significant issues for uric acid are fructose, purines, and alcohol.  [48:20] Should I Follow A Ketogenic Lifestyle If I Have Gout Attacks?  The most significant player in gout is fructose.  When you research how to fix gout, there will be no talk about removing sugar or fructose from your diet.  The human requirement for sugar in our diets is zero grams per day.  We subsidize the growth of corn from which high fructose corn syrup comes from. We are supporting the diseases that are sucking up our healthcare resources. Diseases are significant money makers for the healthcare industry.  It's time we start thinking about prevention.  [52:25] What Role Does Mental-Emotional Stress Play With Uric Acid Levels? When we are experiencing stress, our ability to make rational, forward-thinking decisions is compromised. When your decision-making is compromised, you won't be making good lifestyle choices.  Therefore, under stress, you will eat more foods that have sugar.  Eventually, you will raise uric acid levels and feed the flame of poor metabolic health. It is time to make better decisions by lowering your stress levels.  AND MUCH MORE!   Resources from this episode:  Check out Dr. David Perlmutter's Website: https://www.drperlmutter.com/ Follow Dr. Perlmutter  Facebook: https://www.facebook.com/DavidPerlmutterMd Twitter: https://twitter.com/davidperlmutter YouTube: https://www.youtube.com/user/DavidPerlmutterMD Instagram: https://www.instagram.com/davidperlmutter/ Get Dr. Perlmutter's Books: https://www.drperlmutter.com/learn/books/ Grain Brain: https://www.amazon.com/Grain-Brain-Surprising-Sugar-Your-Killers/dp/0316485136/benazadi-20 Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health: Uric Acid testing device: https://amzn.to/3yjeP8Q https://www.amazon.com/Drop-Acid-Surprising-Controlling-Extraordinary/dp/0316315397/benazadi-20 Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Controlling blood sugar is a key to controlling your energy and maintaining ideal body composition. In this episode Rob talks about the science behind blood sugar. 

This is Dr. Deniz, "The Wellness Doc" bringing you all things healthy for your mind, body, and soul. We were joined in the studio with my co-host, Uncle Pauly for this 2nd episode in season 3 of my podcast, "Comprehensive Health & Wellness "entitled, 3 KEY FACTORS LEADING TO PERMANENT WEIGHT LOSS AND MANAGEMENT, found on major hosting platforms such as SPOTIFY, AMAZON MUSIC, ITUNES, and GOOGLE PODCASTS.  1. Controlling Blood-Sugar and Insulin Release- Research has shown that there is a high correlation between the frequency and amount of foods that raise blood sugar, insulin resistance, and diabetes/pre-diabetes.  Please watch and listen to Dr. Becky Gillaspy explain this concept: https://youtu.be/2lI3dM65Zqo SUPERFOODS: HEALTHY MIND, GUT, AND IMMUNE SYSTEM: https://youtu.be/QWtgI5OP_Ks 7 KEY STEPS TO HEALTHY AGING:https://youtu.be/iqLVXUXq0I8 2. Proper Sleep: Studies have also shown that is a direct incidence between weight gain and insufficient sleep. In short, we can only run on "fumes" for so long as this results in a depletion of specific chemical reactions necessary for optimal systemic functioning.  3. Food Prep- Here's the bottom line, when we prepare our food, we know precisely what we are consuming- there are no surprises, and research has also displayed that people that engage in this behavior on a regular basis have much more success in their weight loss goals. Please take a look at my detailed blog on this topic: https://wordpress.com/post/icemanhealith.wordpress.com/2063 As always, we are here to provide hope, encouragement, support, inspiration, and Specialized Knowledge so that you can optimize your performance in your lives. Here is my new book on Amazon: https://www.amazon.com/Step-Out-Water-Patented-Training/dp/B091GYTYHH Please feel free to contact me via email at: icemanhealith@gmail.com with any questions, comments, guest inquires, or show ideas.   #googlepodcasts #spotifypodcasts #podcastshow #itunespodcasts #thewellnessdoc #drdenizarmagan #amazonmusic #amazonkdp #healthylifestyle #amazonpodcasts #youtubechannel #nutrition #insulin #insulinresistance #bloodsugar #diabetes #pre-diabetes #behaviormodification #holistichealth #permamentweightloss #weightloss #foodheals #healthandwellness #foodprep #healthaging #amazonpodcasts #anchorporcasts #podcasthost #totalwellness #healthyaging #communitytv #ptsdsurvivor #ptsdwarrior

Modern medicine is ignoring a scientific phenomenon that's right under its nose–uric acid.  In this episode, Dr. David Perlmutter, a board-certified neurologist and five-time New York Times bestselling author, reveals the deadly truth about high uric acid levels, as well as offering practical advice, diet hacks, and lifestyle strategies you can implement to manage its levels. Discover how this “insignificant” byproduct of metabolism is at the root of many life-threatening illnesses, and how you can shift your health trajectory for the better in as little as two weeks! You will learn about... The backstory to uric acid + how it helped our ancestors survive How to easily test your uric acid levels  Natural ways to lower uric acid  Purines, alcohol, and uric acid Eating fruit vs drinking juice  Fructose and alcohol The LUV (Lower Uric Levels) Diet Resources: Read: https://www.drperlmutter.com/books/drop-acid/ (Drop Acid: The Surprising New Science of Uric Acid – The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health ) Website: https://www.drperlmutter.com/ (drperlmutter.com) Instagram: https://www.instagram.com/davidperlmutter/?hl=en (@davidperlmutter) https://www.drperlmutter.com/uric-acid-monitor/ (Test your uric acid levels ) Connect with Kelly: https://kellyleveque.com/ (kellyleveque.com) Instagram: https://www.instagram.com/bewellbykelly/ (@bewellbykelly) Facebook: https://www.facebook.com/bewellbykelly/ (www.facebook.com/bewellbykelly) Be Well By Kelly is a production of http://crate.media (Crate Media)

David Perlmutter, MD is a board-certified neurologist and The New York Times best-selling author of Brain Maker, Grain Brain, and Brain Wash. His latest book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health, is out now. Full show notes: https://maxlugavere.com/podcast/217-david-perlmutter-md

This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.Uric acid is a central player in metabolic mayhem. Despite its long association with gout and kidney stones, it's involved in so much more—especially our metabolic disease epidemic. There are three things that raise our levels of uric acid: purines, alcohol, and fructose. The latter is the biggest challenge, due to its overwhelming presence in our Standard American Diet. That doesn't mean all fruit is bad or even that all alcohol and purine-rich foods have the same effect. Like all parts of health and nutrition, there are nuances we need to consider to create optimal health.That's why I'm so excited to take a deep dive into the topic of uric acid with my friend and colleague Dr. David Perlmutter. Dr.Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain among others, and his new book, Drop Acid was just released. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer's Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition.This episode is brought to you by Rupa Health, Thrive Market, and Cozy Earth.Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account here. Thrive Market is an online membership-based grocery store that makes eating well convenient and more affordable. Join today to receive an extra 40% off your first order and a free gift worth over $50 here.Cozy Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, use code MARK40 to get 40% off your Cozy Earth sheets here.Here are more details from our interview (audio version / Apple Subscriber version): What is uric acid and how does it affect our health? (5:30 / 2:00) The impact of fructose consumption on our physiology (11:45 / 8:10) The differences between fructose and glucose (19:20 / 16:29) Why high fructose corn syrup is used in so many foods (21:13 / 17:40) The three sources of uric acid (22:57 / 19:23) Fructose consumption, uric acid, and gut health (28:19 / 23:43) How to eat to reduce uric acid (33:54 / 28:52) Medications that increase uric acid (47:07 / 42:04) Uric acid and Alzheimer's (50:28 / 45:28) Heavy metals, supplements, sleep, exercise, and uric acid (54:12 / 49:14)Get Dr. Perlmutter's new book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary Health here. See acast.com/privacy for privacy and opt-out information.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Structured PH-Balanced Alkaline Water: https://www.ameolife.com or call 1-8-0-0-4-2-2-8-1-4-8, use code DAVE20 to get 20% offMattress Temperature Tech: https://www.eightsleep.com/dave, use code DAVE to save $250 on the Pod ProIN THIS EPISODE OF THE HUMAN UPGRADE™...… guest Dr. David Perlmutter explains how he's an expert in dropping acid, but not in the way you might think. He regular contributor to groundbreaking science, he's back on the show to talk about why you should be paying attention to your uric acid levels. Dr. Perlmutter is a neurologist and five-time New York Times bestselling author. His books include “Brain Wash,” “Grain Brain” and “Brain Maker.” He's recognized internationally as a leader in the field of nutritional influences in neurological disorders. Now, he's turning his attention to how uric acid threatens your metabolic health.Uric acid is a waste product of metabolism, and its levels are a key health marker and indicator of chronic degenerative diseases. When uric acid levels rise, they tell your body to store fat, which messes with your metabolism and poses a danger to your health.Alcohol, purines (breakdown product of DNA and RNA in foods) and fructose (the kind of sugar found in processed foods) are the three main sources of uric acid. Since the days of our primate ancestors, we've lost the ability to break down uricase, so what we choose to consume makes a big difference.“If we can emulate those signals to our DNA and our physiology that have evolved to keep us healthy,” Dr. Perlmutter says, “we're going a long way to offsetting these incredibly powerful metabolic disruptions that are paving the way for the biggest cause of disease on our planet.”His newest book, “Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health,” includes ways to measure, control and track your uric acid levels and key strategies to manage them. You'll find out the top five foods that raise uric acid (hint: fructose earns the No. 1 spot). You'll also find out the five important supplements to take to lower your uric acid levels back into a healthy range.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Check out our sponsors: ButcherBox: Sign up at ButcherBox.com/impact Athletic Greens: Go to athleticgreens.com/impact and receive a FREE 1 year supply of Vitamin D AND 5 free travel packs with your first purchase! InsideTracker: Get 25% off their entire store at insidetracker.com/impacttheoryWhen people hear about uric acid, it's almost always in the context of it being a causal factor for gout.But if more people knew the full extent of how it affects our metabolism, cardiovascular health, and risk for Alzheimer's and dementia, we might pay more attention to it.In this episode of Health Theory, Dr. David Perlmutter returns with the latest research on how uric acid is about much more than just gout.He explains the relationship between uric acid, insulin, and fructose, why it doesn't mean that all fruits are bad for you, and how our modern problem with uric acid is actually the result of a disconnect between evolution and environment.If you want to dive deeper into the latest knowledge bomb from Dr. Perlmutter, you'll definitely want to check out his new book, Drop Acid: The Surprising New Science of Uric Acid - The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary HealthClick here to pre-order: https://amzn.to/3HQykY5 SHOW NOTES:00:00 | Introduction00:43 | Uric Acid and Metabolism06:42 | The Problem With Fructose12:22 | What Does Uric Acid Do?23:58 | Eat to Lower Uric Acid33:43 | The Cause of Type 2 Diabetes41:48 | The Ideal Diet & Lifestyle QUOTES:“A lot of roads lead to the Rome of inflammation, and set the stage for things like Alzheimer's and coronary artery disease. And because of that, it's the reason that a monotherapy or a one drug approach to Alzheimer's, for example, is beyond myopic. It's never going to work.” [03:02]“Our metabolic health globally is in a terrible place. I mean, a third of American adults have hypertension, and 10% of kids aged 12 to 18 have hypertension. That's crazy. 50% of adult Americans will be obese by the year 2030. Not just overweight, but obese.” [04:16]“Elevation of uric acid is associated with an 80% increased risk of dementia, a 55% increase risk of Alzheimer's specifically, and a 165% increased risk of vascular dementia.” [13:53]“What would be the upside of having uric acid create insulin resistance, and therefore cause blood sugar to go up? Why? Because when you're starving, it'll help power your brain.” [16:50]“What we're seeing now are these metabolic derangements that underlie these diseases that represent a disconnect between evolution and environment.” [22:06]“If it has a barcode, and it's in the grocery store, it has added sweetener - 70% do. And by and large that comes from high fructose, there's the villain corn syrup that we subsidize to the tune of $500 billion a year.” [25:01]“Uric acid levels are climbing in lockstep with fructose consumption. In the 1920s, average uric acid level in Americans was about 3.5 - it's now six.” [46:50]Follow Dr. David Perlmutter:Website: https://www.drperlmutter.com Twitter: https://bit.ly/3GRK37j Facebook: https://bit.ly/3Bkb8yZ Instagram: https://bit.ly/3swlmYY Order Dr. Perlmutter's new book, Drop Acid: https://amzn.to/3HQykY5

Check out our sponsors: ButcherBox: Sign up at ButcherBox.com/impact Athletic Greens: Go to athleticgreens.com/impact and receive a FREE 1 year supply of Vitamin D AND 5 free travel packs with your first purchase! InsideTracker: Get 25% off their entire store at insidetracker.com/impacttheoryWhen people hear about uric acid, it's almost always in the context of it being a causal factor for gout.But if more people knew the full extent of how it affects our metabolism, cardiovascular health, and risk for Alzheimer's and dementia, we might pay more attention to it.In this episode of Health Theory, Dr. David Perlmutter returns with the latest research on how uric acid is about much more than just gout.He explains the relationship between uric acid, insulin, and fructose, why it doesn't mean that all fruits are bad for you, and how our modern problem with uric acid is actually the result of a disconnect between evolution and environment.If you want to dive deeper into the latest knowledge bomb from Dr. Perlmutter, you'll definitely want to check out his new book, Drop Acid: The Surprising New Science of Uric Acid - The Key to Losing Weight, Controlling Blood Sugar and Achieving Extraordinary HealthClick here to pre-order: https://amzn.to/3HQykY5 SHOW NOTES:00:00 | Introduction00:43 | Uric Acid and Metabolism06:42 | The Problem With Fructose12:22 | What Does Uric Acid Do?23:58 | Eat to Lower Uric Acid33:43 | The Cause of Type 2 Diabetes41:48 | The Ideal Diet & Lifestyle QUOTES:“A lot of roads lead to the Rome of inflammation, and set the stage for things like Alzheimer's and coronary artery disease. And because of that, it's the reason that a monotherapy or a one drug approach to Alzheimer's, for example, is beyond myopic. It's never going to work.” [03:02]“Our metabolic health globally is in a terrible place. I mean, a third of American adults have hypertension, and 10% of kids aged 12 to 18 have hypertension. That's crazy. 50% of adult Americans will be obese by the year 2030. Not just overweight, but obese.” [04:16]“Elevation of uric acid is associated with an 80% increased risk of dementia, a 55% increase risk of Alzheimer's specifically, and a 165% increased risk of vascular dementia.” [13:53]“What would be the upside of having uric acid create insulin resistance, and therefore cause blood sugar to go up? Why? Because when you're starving, it'll help power your brain.” [16:50]“What we're seeing now are these metabolic derangements that underlie these diseases that represent a disconnect between evolution and environment.” [22:06]“If it has a barcode, and it's in the grocery store, it has added sweetener - 70% do. And by and large that comes from high fructose, there's the villain corn syrup that we subsidize to the tune of $500 billion a year.” [25:01]“Uric acid levels are climbing in lockstep with fructose consumption. In the 1920s, average uric acid level in Americans was about 3.5 - it's now six.” [46:50]Follow Dr. David Perlmutter:Website: https://www.drperlmutter.com Twitter: https://bit.ly/3GRK37j Facebook: https://bit.ly/3Bkb8yZ Instagram: https://bit.ly/3swlmYY Order Dr. Perlmutter's new book, Drop Acid: https://amzn.to/3HQykY5

Why should you drop acid? This may seem like a very provocative question, but it refers to a particular type of acid in your body that you should be aware of. When levels of this acid build-up, it can cause a lot of damage to your metabolic health. We have Dr. David Perlmutter on our show today to discuss the topic in more depth. Dr. Perlmutter is an MD board-certified neurologist and five-times New York Times best-selling author. He's here today to talk about the central idea behind his new book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health. Maintaining excellent brain and body health is essential so that you can leverage all the tools we teach you to unlock your limitless life. Listen in as Dr. Perlmutter gives you actionable steps you can take right now to manage your uric acid and regain control over your metabolism, lower inflammation, and increase your overall well-being. *** Do you want to stay up to date with every new episode and get my brand new Kwik Brain Accelerator Program? Go to www.KwikBrain.com/podcast to get instant access. *** Or text me 310-299-9362 to get your burning questions answered and an insider sneak peek of exciting updates. I do my best to answer as many as I can each day, so shoot me a message today.

This episode is brought to you by ButcherBox and InsideTracker.Researchers around the globe over the past decade have revealed that uric acid, previously thought of only in terms of gout, actually plays a central role in metabolic disorders. So, how is uric acid orchestrating this metabolic mayhem?This week on The Dhru Purohit Podcast, Dhru sat down with Dr. David Perlmutter to talk about how uric acid plays a major role in fat storage, insulin resistance, and other metabolic and chronic degenerative diseases that are driving illness and death in our country. Dr. David Perlmutter is a board-certified neurologist and five-time New York Times bestselling author. He serves on the board of directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain, among other works, and his upcoming book, Drop Acid, comes out February 15, 2022. In this episode, we dive into: -Surprising foods that drive uric acid levels (7:23)-How elevated uric acid levels directly lead to increased fat storage (9:16)-The consequences of elevated uric acid (15:38)-The main culprits that lead to elevated uric acid levels (17:42)-How to test uric acid levels and what the optimal range is (29:49)-The relationship between elevated uric acid and the risk of heart disease and Alzheimer's (35:38)-The biggest drivers of fructose in our diet (46:43) -The connection between foods rich in purines and uric acid (1:09:15) -Why you should avoid agave at all costs (1:25:34)-Quercetin and how it helps lower uric acid levels (1:31:11) Also mentioned in this episode-UASure Uric Acid Meter - https://www.uasure.com/For more on Dr. David Perlmutter, follow him on Instagram @davidperlmutter, Facebook @davidperlmuttermd, Twitter @davidperlmutter, YouTube @davidperlmuttermd, and through his website https://www.drperlmutter.com/. Get his book Drop Acid at https://www.drperlmutter.com/books/drop-acid/.This episode is brought to you by ButcherBox and InsideTracker.For a limited time, new subscribers to ButcherBox will receive ground beef FOR LIFE. When you sign up today, ButcherBox will send you 2 lbs of 100% grass-fed, grass-finished beef free in every box for the life of your subscription. To receive this offer, go to ButcherBox.com/dhru.InsideTracker provides detailed nutrition and lifestyle guidance based on your individual needs. Right now, they're offering our podcast community 25% off. Just go to insidetracker.com/DHRU to get your discount and try it out for yourself. See acast.com/privacy for privacy and opt-out information.

Today's guest is Dr. David Perlmutter, who is a Board-Certified Neurologist and five-time New York Times bestselling author. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award and he currently serves on the Board of Directors and is a Fellow of the American College of Nutrition. He's written a new book Drop Acid: The Surprising New Science of Uric Acid―The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health.In this episode we discuss how your diet can contribute to your behavior, the real reason most people are addicted to sugar, how to reduce the risk of Alzheimers and other diseases, the emerging science behind uric acid and everything you need to know about its effects on the body, and so much more!For more go to: www.lewishowes.com/1211Check out Perlmutter's website - www.drperlmutter.comRead his new book - www.dropacidbook.comThe Wim Hof Experience: Mindset Training, Power Breathing, and Brotherhood: https://link.chtbl.com/910-podA Scientific Guide to Living Longer, Feeling Happier & Eating Healthier with Dr. Rhonda Patrick: https://link.chtbl.com/967-podThe Science of Sleep for Ultimate Success with Shawn Stevenson: https://link.chtbl.com/896-podSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

David Perlmutter MD reveals the exciting and challenging science behind a major health risk that almost no one is talking about. Find out how uric acid is contributing to some of the biggest health risks in modern life, how the standard American diet is the perfect formula for creating dangerous levels of uric acid in your body, and how you can make changes to your diet that will help you lose weight, control your blood sugar, and live a healthier life.  [1:40] As of 2022, David will be 67 years young and he's planning on traveling from Vancouver to Alaska with his wife. The world has a lot of variability and uncertainty right now so it's hard to make detailed plans for the following year, but in some ways, that's good because it forces you to focus on the present. [5:00] David's new book is called Drop Acid. It specifically deals with uric acid and how we discovered it to be a central player in regulating metabolic health. It's not only that uric acid just becomes elevated, it actually plays a causal role in conditions like diabetes, hypertension, and obesity. [7:45] Metabolic issues are the number one cause of mortality on the planet. Countries like Japan have been aggressive in intervening with people with high levels of uric acid because of its dramatic associations with death from all causes. [8:25] Risk of death due to cardiovascular disease rises by 38%, stroke by 35%, and for every point of elevation in uric acid above 7 all cause mortality increases by 8%-13%. Having a high uric acid level is associated with a 80% risk of dementia, and a 55% risk of Alzheimer's. [10:00] Testing uric acid levels is fairly routine, but what it indicated wasn't meaningfully understood until recently. David began looking at uric acid because of his interest in metabolic health and its association to Alzheimer's. The original paper linking uric acid to metabolic issues was published in 1894, and was buried until a researcher named Dr. Richard Johnson started doing studies on it. [12:15] David was listening to a podcast episode with Dr. Peter Attia doing an interview with Dr. Johnson and he was overwhelmed by the information. Every minute was a new pearl of information. David started communicating with Dr. Johnson, which became the basis of a new friendship. [14:30] The genetic mutations that cause humans to have higher uric acid than other mammals happened around 14 to 17 million years ago as an evolutionary survival mechanism. In times of food and water scarcity, uric acid allowed us to increase our blood sugar and retain water which were powerful advantages. [15:45] To this day, we have a component of our genes that want to be thrifty and pack away fat for the next period of food scarcity. Historically, the biggest threats to our survival was in finding food sources and being eaten by predators, and uric acid helped with both of those. [16:55] Certain cultures have evolved this gene and are more at risk of negative effects from it in our modern world. Fructose is the key ingredient to uric acid production in the body and the world is awash with it. The highest rates of obesity are in those genetic populations. [18:50] 50% of American adults will be obese by 2030, including children. 10% of kids between 12 and 18 are hypertensive. This is a direct manifestation of the foods we are eating, primarily fructose. Fructose is metabolized into uric acid and uric acid is doing the dirty work. [20:10] In the context of 99.9% of human habitation on this planet, this adaptation was very advantageous. It wasn't until recently, when our diets have changed so significantly, that it has become a liability. [21:15] Clearing uric acid is where the challenge is. We have lost the function to clear uric acid and with most foods we eat increasing uric acid levels, it can be difficult to keep levels low on the standard American diet. Fructose is the main culprit and average daily consumption increased by 1000% between 1970 and 1990. {24:30] Not all alcohol is associated with high levels of uric acid, but beer is one of the worst contributors. Targeting a specific enzyme called xanthine oxidase can help the body excrete uric acid. [27:20] In menopause, uric acid increases because estrogen plays a major role in the kidney's ability to excrete uric acid. Women who are on estrogen replacement therapy seem to have some protection from their uric acid rising. [28:30] One of the most important discoveries has to do with a master pathway known as AMPK. This pathway is turned on by things like exercise, berberine, and metformin, and when activated, it prevents the body's production of extra glucose and sugar. [31:45] The opposite of AMPK is triggered by two ways: fructose entering the body and uric acid in general. Uric acid is the key to the ability to hibernate, but if you don't plan on spending the four to six months sleeping, you should try to keep uric acid low to maintain your metabolic health. [33:55] For people who are working hard to lose weight and get healthy, reducing uric acid may be the vital tool they need. Picking up a uric acid monitor will give you a good idea where you are right now. We want to have a uric acid level below 5.5 mg/deciliter, with the average level in America being around 6.0. [37:40] The average individual in America, aged 60 or older, has full blown metabolic syndrome. 88% of adults in America have at least one component of metabolic syndrome. [38:30] The LUV diet can be incorporated into your keto, paleo, or vegan plan. The main focus is in getting the fructose out of your life. [39:15] Fruit has fructose but when you eat fruit you're getting that fructose in the context of fiber, bioflavonoids and Vitamin C. Fruit juice consumption is associated with an overall smaller brain and weaker memory. [41:00] Tart cherries were used in the past with women to help them control their gout, and now through the lens of modern research we know why. [41:30] We've known since 1970 that fructose is a threat to metabolic health, despite the $10 billion that was spent to keep us from that information. $500 million was spent to convince the public that corn related sugar was the “safer” sugar. Fortunately the truth is now coming out and we are waking up to the risks of uric acid. [42:40] David published an op-ed challenging the Biden administration on the USDA recommendation that 10% of our daily calorie consumption should come from sugar. This is a perfect example of science coming up against politics. [44:10] The nutritional requirement of sugar is zero. High fructose corn syrup is a toxin to fetal health. When it comes to certain organizations, it's like steering an aircraft carrier, especially when you look at which groups may be funding those organizations. [46:20] The only time we would need fructose in our bodies is when facing starvation, and even then our bodies can create fructose from glucose. [48:25] The quick fix is to eat less salt and your body will be less aggressive in triggering the pathway that leads to high uric acid levels. [49:00] One study looked at two groups of school-aged children, and in one group they placed a water fountain outside their classroom and encouraged them to drink. That group had a 30% reduction in the development of obesity. Fat is a powerful resource for making fresh water in your body, and when we're dehydrated (or our body thinks we're dehydrated) it wants to store fat to survive.     Mentioned in this Episode: Drop Acid by David Perlmutter drperlmutter.com youtube.com/thegirlfrienddoctor dranna.com/show     Always seek the advice of your own physician or qualified health professional before starting any treatment or plans. Information found here and results are provided for informational purposes only and are not intended to replace a one-on-one relationship with a qualified healthcare professional and are not intended as medical advice.

David Perlmutter reveals the exciting and challenging science behind a major health risk that almost no one is talking about. Find out how uric acid is contributing to some of the biggest health risks in modern life, how the standard American diet is the perfect formula for creating dangerous levels of uric acid in your body, and how you can make changes to your diet that will help you lose weight, control your blood sugar, and live a healthier life.  [1:40] As of 2022, David will be 67 years young and he's planning on traveling from Vancouverto Alaska with his wife. The world has a lot of variability and uncertainty right now so it's hard to make detailed plans for the following year, but in some ways, that's good because it forces you to focus on the present. [5:00] David's new book is called Drop Acid. It specifically deals with uric acid and how we discovered it to be a central player in regulating metabolic health. It's not only that uric acid just becomes elevated, it actually plays a causal role in conditions like diabetes, hypertension, and obesity. [7:45] Metabolic issues are the number one cause of mortality on the planet. Countries like Japan have been aggressive in intervening with people with high levels of uric acid because of its dramatic associations with death from all causes. [8:25] Risk of death due to cardiovascular disease rises by 38%, stroke by 35%, and for every point of elevation in uric acid above 7 all cause mortality increases by 8%-13%. Having a high uric acid level is associated with a 80% risk of dementia, and a 55% risk of Alzheimer's. [10:00] Testing uric acid levels is fairly routine, but what it indicated wasn't meaningfully understood until recently. David began  looking at uric acid because of his interest in metabolic health and its association to Alzheimer's. The original paper linking uric acid to metabolic issues was published in 1894, and was buried until a researcher named Dr. Richard Johnson started doing studies on it. [12:15] David was listening to a podcast episode with Dr. Peter Attia doing an interview with Dr. Johnson and he was overwhelmed by the information. Every minute was a new pearl of information. David started communicating with Dr. Johnson, which became the basis of a new friendship. [14:30] The genetic mutations that cause humans to have higher uric acid than other mammals happened around 14 to 17 million years ago as an evolutionary survival mechanism. In times of food and water scarcity, uric acid allowed us to increase our blood sugar and retain water which were powerful advantages. [15:45] To this day, we have a component of our genes that want to be thrifty and pack away fat for the next period of food scarcity. Historically, the biggest threats to our survival was in finding food sources and being eaten by predators, and uric acid helped with both of those. [16:55] Certain cultures have evolved this gene and are more at risk of negative effects from it in our modern world. Fructose is the key ingredient to uric acid production in the body and the world is awash with it. The highest rates of obesity are in those genetic populations. [18:50] 50% of American adults will be obese by 2030, including children. 10% of kids between 12 and 18 are hypertensive. This is a direct manifestation of the foods we are eating, primarily fructose. Fructose is metabolized into uric acid and uric acid is doing the dirty work. [20:10] In the context of 99.9% of human habitation on this planet, this adaptation was very advantageous. It wasn't until recently, when our diets have changed so significantly, that it has become a liability. [21:15] Clearing uric acid is where the challenge is. We have lost the function to clear uric acid and with most foods we eat increasing uric acid levels, it can be difficult to keep levels low on the standard American diet. Fructose is the main culprit and average daily consumption increased by 1000% between 1970 and 1990. {24:30] Not all alcohol is associated with high levels of uric acid, but beer is one of the worst contributors. Targeting a specific enzyme called xanthine oxidase can help the body excrete uric acid. [27:20] In menopause, uric acid increases because estrogen plays a major role in the kidney's ability to excrete uric acid. Women who are on estrogen replacement therapy seem to have some protection from their uric acid rising. [28:30] One of the most important discoveries has to do with a master pathway known as AMPK. This pathway is turned on by things like exercise, berberine, and metformin, and when activated, it prevents the body's production of extra glucose and sugar. [31:45] The opposite of AMPK is triggered by two ways: fructose entering the body and uric acid in general. Uric acid is the key to the ability to hibernate, but if you don't plan on spending the four to six months sleeping, you should try to keep uric acid low to maintain your metabolic health. [33:55] For people who are working hard to lose weight and get healthy, reducing uric acid may be the vital tool they need. Picking up a uric acid monitor will give you a good idea where you are right now. We want to have a uric acid level below 5.5 mg/deciliter, with the average level in America being around 6.0. [37:40] The average individual in America, aged 60 or older, has full blown metabolic syndrome. 88% of adults in America have at least one component of metabolic syndrome. [38:30] The LUV diet can be incorporated into your keto, paleo, or vegan plan. The main focus is in getting the fructose out of your life. [39:15] Fruit has fructose but when you eat fruit you're getting that fructose in the context of fiber, bioflavonoids and Vitamin C. Fruit juice consumption is associated with an overall smaller brain and weaker memory. [41:00] Tart cherries were used in the past with women to help them control their gout, and now through the lens of modern research we know why. [41:30] We've known since 1970 that fructose is a threat to metabolic health, despite the $10 billion that was spent to keep us from that information. $500 million was spent to convince the public that corn related sugar was the “safer” sugar. Fortunately the truth is now coming out and we are waking up to the risks of uric acid. [42:40] David published an op-ed challenging the Biden administration on the USDA recommendation that 10% of our daily calorie consumption should come from sugar. This is a perfect example of science coming up against politics. [44:10] The nutritional requirement of sugar is zero. High fructose corn syrup is a toxin to fetal health. When it comes to certain organizations, it's like steering an aircraft carrier, especially when you look at which groups may be funding those organizations. [46:20] The only time we would need fructose in our bodies is when facing starvation, and even then our bodies can create fructose from glucose. [48:25] The quick fix is to eat less salt and your body will be less aggressive in triggering the pathway that leads to high uric acid levels. [49:00] One study looked at two groups of school-aged children, and in one group they placed a water fountain outside their classroom and encouraged them to drink. That group had a 30% reduction in the development of obesity. Fat is a powerful resource for making fresh water in your body, and when we're dehydrated (or our body thinks we're dehydrated) it wants to store fat to survive.     Mentioned in this Episode: Drop Acid by David Perlmutter drperlmutter.com youtube.com/thegirlfrienddoctor dranna.com/show     Always seek the advice of your own physician or qualified health professional before starting any treatment or plans. Information found here and results are provided for informational purposes only and are not intended to replace a one-on-one relationship with a qualified healthcare professional and are not intended as medical advice.

Neurologist Dr. David Perlmutter, known to most Defiant Health listeners as The NY Times bestseller author of Grain Brain, as well as Brain Maker and Brain Wash, makes some surprising and enlightening observations about a blood marker called uric acid. Up until recently, uric acid was thought to be the factor that caused gout and kidney stones. But Dr. Perlmutter reports on emerging science that shows that tracking uric acid is almost as crucial to health as tracking blood sugar and that uric acid underlies many common chronic diseases. Understand what your uric acid level means, then take natural action to bring it under control to gain advantages in health and risk for many health conditions. Dr. Perlmutter's newest book is Drop Acid: The Surprising New Science of Uric Acid--The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health to be released Feb 15, 2022 and available through all major bookstores including Amazon, Barnes & Noble, and Indie Books. More of Dr. Perlmutter on Facebook: www.facebook.com/DavidPerlmutterMdGet your Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, and low-carb snack bars:Use the coupon code "Defiant" for an additional 15% discount. Go to this page on the Paleovalley website, enter the code and the discount will be automatically applied to your order:https://paleovalley.com/offers/grass-fed-beef-sticks-bk-lt-promo/defiant?uid=123&oid=2&affid=733For more information on Dr. Davis' programs:Books:Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded editionWheat Belly 10-Day Grain DetoxWheat Belly 30-Minute (Or Less!) CookbookUndoctored: Why Health Care Has Failed You and How You Can Become Smarter Than Your DoctorOnline media:Wheat Belly Blog: www.wheatbellyblog.comWheat Belly Facebook page: https://www.facebook.com/OfficialWheatBelly/Wheat Belly 10-Day Grain Detox private Facebook page: https://www.facebook.com/groups/527516110738721/Undoctored Inner Circle (membership website with direct interaction with Dr. Davis):InnerCircle.Undoctored.comYouTube Channel:https://www.youtube.com/channel/UCZp4ONYOXZkf92UxxNnAiKQAnd, of course, subscribe to the Defiant Health podcast through your favorite podcast directory!

In this episode the Crew dials the voicemail to answer a question from a loyal Power Athlete Radio listener: Morning guys, this is Mike from North Carolina. I got a question for the Crew. Oftentimes John breezed over how he was in Flint and sedatives at one time during his career and that he fixed… The post Ep 552 – Controlling Blood Sugar and Living Your Life first appeared on Power Athlete.

In a companion interview to his June 7 talk with Stanford's Michael Snyder, Harry speaks this week with Noosheen Hashemi, who—with Snyder—co-founded the personalized health startup January.ai in 2017. The company focuses on helping users understand how their bodies respond to different foods and activities, so they can make diet and exercise choices that help them avoid unhealthy spikes in blood glucose levels.January's smartphone app collects blood glucose levels from disposable devices called continuous glucose monitors (CGMs), as well as heart rate data from patients' Fitbits or Apple Watches. The app also makes it easier for users to log the food they eat, and see what impact each food has on their glucose levels. Once the app has enough data, January's machine learning algorithms can start predicting the effects of different foods and activities on blood glucose. It can then recommend meals and exercise that'll help users keep their blood glucose in a healthy target range. The goal isn't to prevent glucose spikes completely, but rather to prevent diabetes from emerging over the long term in people at risk for a cluster of serious conditions known metabolic syndrome. That could help individuals live longer, healthier lives. And at a population level it could save billions in healthcare costs.Please rate and review MoneyBall Medicine on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:• Launch the “Podcasts” app on your device. If you can't find this app, swipe all the way to the left on your home screen until you're on the Search page. Tap the search field at the top and type in “Podcasts.” Apple's Podcasts app should show up in the search results.• Tap the Podcasts app icon, and after it opens, tap the Search field at the top, or the little magnifying glass icon in the lower right corner.• Type MoneyBall Medicine into the search field and press the Search button.• In the search results, click on the MoneyBall Medicine logo.• On the next page, scroll down until you see the Ratings & Reviews section. Below that, you'll see five purple stars.• Tap the stars to rate the show.• Scroll down a little farther. You'll see a purple link saying “Write a Review.”• On the next screen, you'll see the stars again. You can tap them to leave a rating if you haven't already.• In the Title field, type a summary for your review.• In the Review field, type your review.• When you're finished, click Send.• That's it, you're done. Thanks!Full TranscriptHarry Glorikian: I'm Harry Glorikian, and this is MoneyBall Medicine, the interview podcast where we meet researchers, entrepreneurs, and physicians who are using the power of data to improve patient health and make healthcare delivery more efficient. You can think of each episode as a new chapter in the never-ending audio version of my 2017 book, “MoneyBall Medicine: Thriving in the New Data-Driven Healthcare Market.” If you like the show, please do us a favor and leave a rating and review at Apple Podcasts.Harry Glorikian: I've been making the show long enough that you can see a kind of family tree emerging, with branches that connect many of our episodes.That's definitely the case with today's interview with Noosheen Hashemi, the co-founder and CEO of the precision health company January AI.The branch leading to Hashemi started back in June of 2021 when I interviewed Professor Michael Snyder, the chair of Stanford's Department of Genetics.Snyder is a huge proponent of using wearable devices to help people make better decisions about their own health. In fact, the day we spoke he was wearing seven separate devices, including one called a continuous glucose monitor or CGM.A CGM is standard equipment these days for about 3.5 million diabetics in the U.S. who need to know when their blood sugar is too high and when it's time to take more insulin. But Snyder believes that blood glucose data could also help tens of millions of other people who don't yet take insulin but may be on their way to developing full-blown diabetes.Back in 2016 Snyder got a visit from Hashemi. She's a longtime Silicon Valley tech executive and philanthropist who'd been searching for a way to use AI, wearable devices, and big data to get more people involved in medical research. Hashemi told me it took just two meetings for her and Snyder to decide to join forces to co-found January. The company makes a smartphone app that collects blood glucose data from disposable CGMs, as well as heart rate data from patients' existing wearable devices such as their Fitbit or Apple Watch. The app also makes it easier for users to log the food they eat, and see what impact each food has on their glucose levels. Once the app has enough data, January's machine learning algorithms can start predicting the effects of different foods and activities on blood glucose. It can then recommend meals and exercise that'll help users keep their blood glucose in a healthy target range. The goal isn't to prevent glucose spikes completely, but rather to prevent diabetes from emerging over the long term in people at risk for a cluster of serious conditions known metabolic syndrome. That could help individuals live longer, healthier lives. And at a population level it could save billions in healthcare costs.As you're about to hear, Hashemi and I talked about why glucose monitoring is so important and what companies like January can do in the future to make the predictive power of AI available to more people.Harry Glorikian: Noosheen, welcome to the show. Noosheen Hashemi: Thank you, Harry. Harry Glorikian: So, it's great to have you on the show. It was interesting that, you know, the minute Dr. Snyder mentioned the company, I was immediately Googling it. And I was like, oh, I have to talk to this company. I have to understand what they're doing and, and what's going on.And to be quite honest, I've been doing my homework for the past couple of weeks. And I'm like: I think I have to call my doctor and get a ‘script to actually use the product. Just to help everybody get up to speed on this, can you bring people up to speed on where we are with glucose monitoring and health in general? Whether they have diabetes or whether they're just, you know, what, I, maybe someone like me who I hope is a generally a healthy person.Noosheen Hashemi: Sure, absolutely.  Yeah. So from Mike Snyder's four-year multi-omic IPOP research,  we learned that people who are so-called healthy and have healthy A1C levels could actually have huge glycemic variability. He sometimes calls these people with pre pre-diabetes.  I think eight people developed diabetes during his four-year study.There haven't been enough longitudinal studies in healthy people with glycemic variability to suggest that they will necessarily develop diabetes. So to date, there's really no conclusive evidence that healthy people can benefit from balancing their blood sugar. Also, not all sugar spikes are bad and a two-hour bike ride might produce a big spike, but that's fine. It's not the spike by itself that we worry about. It's really  how high the spike is against our baseline, against the population, whether the spike comes down quickly, the shape of the curve, the area under the curve. These are the things that are illuminating in terms of our state of metabolic health.So  at January we really view metabolic health as a spectrum. So we want to support people to figure out kind of where they are on that spectrum. And to try to really help them move up to healthier points on that spectrum. So we don't see it as a moment in time where you are something or you are not something. You are kind of on a spectrum of metabolic health, and we continuously want you to be self-aware and, and really improve your location on that spectrum. Now, something to keep in mind,  and why I think it's important for people to take action on this, is that 84% of the 88 million people believed to have pre-diabetes today, and 22% of the 34 million people that are believed to have diabetes today, are not diagnosed. They are undiagnosed. That's 75 million people walking around with pre-diabetes and don't even know. So, if we don't measure people's health, that doesn't mean they're healthy.  So we really encourage people to be  you know, vigilant with their health learn so that they can, they can act, you know, self-advocate. Be able to self-manage.So we do think that wearables are an easy, useful way to kind of see where things are, but then you need companies like January to make sense of it all. Harry Glorikian: Yeah. I mean  you know, it's interesting because you know, I'll go to my doctor and they'll do that one time measurement. It's like taking your car in and you're like, it was making a noise. It's not making the noise right now, but, you know, try and diagnose when that event is not happening. Whereas with the wearables, I can, I can actually see, you know, my, my heart rate variability change depending on my exercise process. I can see my sleep change if I had one too many glasses of wine. I have to tell you, I hate it because I would like to have more wine than my monitor allows me to have, but you know, you see the immediate feedback, which would let you sort of course-adjust accordingly. And you know, when I, there was a paper, I believe that was published in Israel where there, I think it was 500 people that they looked at and where you could see that every person, they could eat the same foods, but their spikes would be different or how long that spike would be based on genetics, based on their microbiome. And so if you're not monitoring, how will you know that your quote, healthy diet is actually healthy for you? Noosheen Hashemi: You don't.  You definitely don't. And yes, that's study shows variability between people, but also we've shown glycemic variability for the same person. So we had somebody at the office have the same good sleep nine days in a row, and they had a different glycemic response to that. Mostly every single day, nine days in a row, depending on how much they had slept, how stressed they were, how much workout they had done. And most importantly, how much fiber was in there.  So we are radically different person to person, and this is why we encourage people.  No one is going to know you as well as you do. And no one's going to be as interested in your health as you are  as you should be, as you might be. So we really encourage people to learn, learn, be self-aware self-advocate, self-educate. Harry Glorikian: So, help people understand this term metabolic syndrome, you know, and, and talk about how many people, maybe who are pre-diabetic go to full-blown diabetes, you know? Noosheen Hashemi: Okay. Yeah. So  I mentioned that 122 million people have either diabetes or pre-diabetes in America.  88 million plus 34 [million]. And then a larger number of people, if you believe Mike Snyder's pre-diabetes number, that's even a larger number. But metabolic syndrome is a cluster of conditions that leads to type 2 diabetes, heart disease, and stroke. These conditions are basically high blood sugar—which has been historically measured by A1C  blood tests called hemoglobin A1C, but increasingly it's measured by time and range using a CGM—high cholesterol and triglyceride levels, high blood pressure, high BMI, and high waist to hip ratio. So this kind of fat right in the middle.So the 2002 diabetes prevention study showed that unless there's an intervention, 58% of the people that have pre-diabetes could end up with diabetes. And usually they think of this prevention as weight loss.That's what the DPP programs, diabetes prevention programs, are about.So if you have pre-diabetes the cells in your body don't respond normally to insulin. And insulin is a hormone that facilitates your cells taking up glucose, which is a source of energy for your body. Your pancreas basically makes more insulin to try to get the cells to take up glucose. You sort of get into this terrible vicious circle. So eventually your pancreas can't keep up and then you have this sort of excess sugar sitting in your bloodstream, which is really a problem. And it can really lead to microvascular complications like retinopathy or neuropathy or diabetic nephropathy.So as you know, diabetic retinopathy is the most common cause of blindness in working adults in the developed world. And in diabetic neuropathy, essentially high blood sugar can injure nerves throughout the body. And usually damages nerves in the feet, in the legs and feet, which hear about foot ulcers and amputations coming from this.And of course  diabetic kidney disease. Nephropathy is something that  is the number one cause of kidney failure, actually. Almost a third of people with diabetes develop kidney disease. So you add this with the high blood pressure we can increase the force of blood through your arteries and damage arteries. And then you have excess blood pressure, you knowblood pressure and diabetes together, basically increase your risk for heart disease. So it's really a terrible cluster of conditions to have. And so if you have three of these conditions, three of these five, you essentially have metabolic syndrome. And if you have metabolic syndrome, you're at a higher risk of developing these different diseases. You really don't want to go down this path. The path itself is not great. And then the comorbidities from this path are just worse and complications of course are very painful, costly, and potentially, deadly.Harry Glorikian: And so that's one end of the spectrum, but in reality, even someone like me who tries to watch he eats, who goes running regularly, or tries to go running regularly. I mean, you know, I have sleep apnea because they tell me my BMI is too high. Right. So  but this sort of technology, you know, I could be spiking and keeping a high glucose level, which would inhibit my ability to lose weight, et cetera. So how can more data about blood glucose, and its relationship to diet, help people avoid diabetes?Noosheen Hashemi: Yeah. So for so long, we've been able, we've been told just to avoid refined sugar, refined flour, eat a lot of vegetables, walk 10,000 steps. You'll be fine. Or, you know, weight loss is given as the end goal to cure all diseases. You know, why don't you, Harry, drop 25 pounds? Or how about drop 5 to 10% of your weight? Harry Glorikian: Just like that!Noosheen Hashemi: It's true, weight loss really improves biomarkers. But how many people who get this advice can actually do that? And at the timeframe that they need to. So we feel like that's just not a practical approach to solving a problem.A more practical approach is to really figure out what works for each individual. You know, you mentioned you've dialed your own wine drinking based on its impact. I've done the same. I was, you know, enjoying two, three sips of wine. And then I learned that it would wake me up in the middle of the night. So I stopped having even the two, three sips of wine. So don't feel bad that you can't have your second and third and fourth glass. But basically we offer a multitude of levers that you can dial for your lifestyle. For example, intermittent fasting and calorie restriction together have shown benefits in clinical studies for improving insulin sensitivity, if you do them together. So you can't just fast and then gorge yourself. But if you fast and you restrict your calories together, you can really improve insulin sensitivity. So we let you, we help you using the January program to learn to experiment with fasting and calorie restriction and figure out what works for you. How much of it you can make. You know, slowly  help you essentially build it into your habits and your daily routines to fast. You know, we increase your fasting period 15 minutes at a time. So you may start with January you're eating 16 hours a day and you're fasting eight hours. You may end the program having reversed that.And other thing is we, we really pro promote fiber consumption. So increased fiber intake has been associated with higher levels of bacteria-derived short chain fatty acids, which is a regulator of GLP-1 production. As you know, GLP-1 is an incretin and a recognized regulator of glycemic homeostasis and satiety. So we help you track how much fiber you're eating. We encourage you to eat more, knowing what foods spike you, spike your blood sugar, helps you basically eliminate or reduce consumption of those foods. It tells you how much, how much of those things to eat  or alternatives that kind of honor your food preferences  and food tastes, but have lower glycemic index. If you can't walk 10,000 steps a day, okay. January tells you how much you need to walk, when you need to walk to keep your blood sugar in a healthy range. So you really need data  to, to dial your lifestyle. There are many levers and there are no silver bullets and there's too much to keep in your head. Which is why it's nice to have AI sort of help you kind of make, you know, take it all in to a platform and then synthesize it and give you insights.Harry Glorikian: Yeah. I mean, like,  I've got my, my Apple Watch. I've got my, you know, Whoop band. Right.I don't have as many as he [Mike Snyder] does, but  I know, I think my wife would kill me if I, if I was wearing eight things, but, but it's, you know, it's true. Like it's, you know, each one of these, because they're not holistically designed, give me a different piece of data that then I can then react to. You know, one is probably more of a coach that causes me to push a little bit farther, you know, et cetera. So  I mean, I hope one day we evolve to something that's a little bit more holistic so that the average person can sort of, it becomes more digestible and more actionable. But you know, I do believe, based on my conversation with him and even all the work that I do multi-factorial biomarkers or multi biomarkers are going to be how you manage, you know, yourself much better.But you know, tell me how January started. What is the thing that excited you about what you saw and what attracted you to this role? Noosheen Hashemi: Yes, absolutely. So January's origin story started with me deciding in 2016 to start my own company, essentially, after many years of running a family office, investing in, serving on boards of companies and nonprofits.  I had early success at Oracle  where I rose basically from the bottom of the organization in 1985 to vice-president by age 27. Along [with] Mark Benioff, who at the time was 26. It was quite the time, taking the company from $25 million to $3 billion in revenue. So  you know  a really, really amazing tenure there. In 2016, I started this massive research in, into theses that were getting a lot of attention, you know, big trends over the next decade. And most importantly, what I really knew. You know, the classic kind of [inaudible].  I happened to attend a conference, a White House Stanford University conference on societal benefits of AI and how to integrate sort of ever-changing AI into everyday life and into the real world. It was a healthcare panel that took my breath away. So Faith A. Lee who had organized the conference with Russ Goldman. They suggested that interested parties run off to this machine learning and healthcare conference in LA two weeks. I immediately booked my ticket. And there I met Larry Smarr. I don't know if you've come across him or not, but he was the first quantified self, maniacal quantified self person I had come across. And he had diagnosed his own Crohn's disease way before symptoms had manifested. And so, and then the common theme of this conference, between all of these presentations was that machine learning could essentially fill in for missing variables in research, not just going forward, but going backwards. So I was just hooked and I never looked back.But it was a hard problem. My own husband had been investing in healthcare and warned of like an opaque sector. He was like, “Honey, this is heavily regulated incentives are aligned with acute disease, not with chronic disease, not to mention even anything or prevention. It's just not a market economy.” And he knew how interested I am in market economies. My first love before medicine was economics. So that's a whole different podcast. So he warned that I'd be sort of fighting this uphill battle, but I was not discouraged. I basically kept on researching.I came across the MIT economist Andrew Lo. I don't know if you've come across him, but you should definitely talk to him. He's brilliant. His work showed that so little research had been done compared to what we really need to do in terms of medical research. And he comes up with ways of funding, medical research, he has a lot of innovative ways that we could really change  the whole model of medical and scientific research, but it kind of became obvious to me that the answer was that we needed to get everyone involved in research.So just, just putting things in perspective. After Nixon declared a war on cancer 50 years ago, we now have some therapeutics and some solutions to cancer. We have really nothing for neurological diseases. We're spending over $300 billion just on symptoms of Alzheimer's— don't talk about even the cure or anything like that. We have nothing for aging, which is the ultimate killer. So it was, to me, the answer was obvious, which was, we have to get everyone contributing to research. Everyone should be looking at themselves. And then with the data, we can also learn across populations. And so deep phenotyping of the population sort of in a multi-omic way was the answer.And that's what led me to Mike Snyder. I actually looked for multi-omics. I went to Stanford medical school and I met with the CEO. He said, what are you interested in? I said I'm interested in multi-omics. He said, you have to talk to Mike Snyder. And so  basically what Larry Smarr had done at the [San Diego Supercomputer Center] was to measure everything by himself. But Mike had essentially extended this kind of research to others, not just to himself. So not only sort of diagnosed himself with diabetes before the doctors, but he'd also run the Human Microbiome Project, the IPOP study, innumerable other research using metabolomics, proteomics, transcriptomics, wearables, and so on.So he had spent a lifetime studying how people went from healthy to disease essentially. And he had taken a whole person approach, which is what I was interested in.  And so in his role as chairman of genetics at Stanford and head of precision medicine at Stanford, he was kind of already living in the future. And that's kind of where I thought, you know, all of us needed to go. So our first meeting was supposed to take 45 minutes. It took 90 minutes. And in our second meeting, we agreed to join forces. It was like, it was instant.  It was just instant chemistry. Like the universe just brought us together.And then all of a sudden sort of everything fell into place for me. Looking back at my life, I been getting ready for this actually all along. Caring for my dad who had been diagnosed with cancer too late to actually give him  a surviving chance. My mom  had been misdiagnosed with asthma when she had heart failure. So I had to leave my family, you know, everyone get together and really intervene. Really changed her, her lifestyle in order to save her life. She is thankfully now 91 years old and living fine, but it has absolutely no salt in her life and a completely different, different life. My own health, my own health journey sitting in front of a computer for three decades, more than three decades, as we know that now they call it called sitting, you know, Harry Glorikian: Right, the new smoking. Noosheen Hashemi: The new smoking. My experience running a couple of hardware companies, my love of food, and my skills of kind of scaling companies. You know, all of this came together. I just basically became obsessed with prevention and I felt that, you know, food could play an outsized role.So wearables, you know, give you signals from the body continuously, which is incredible.  But you also need to understand what people are eating and, you know, we can talk about that a little bit later, but we can basically now imagine predicting chronic conditions, much like Larry and Mike had. And then, you know, postponing and potentially preventing them. And if they've already started, prevent them. Harry Glorikian: Yeah, I was lucky enough to be there and help when Evidation Health was getting off the ground and, you know, once we started to see the data coming in, I remember looking at the data. Is that real, like, is that actually happening? And I was like, the first thing I was thinking of was like, how do we design a clinical trial? Like if you're going to actually say that's happening, that trial is not going to be trivial to set up, to make that claim, but you could see it in the data.And, you know  I actually think some of the shifts that you're talking about, if it wasn't for things like the Affordable Care Act, if it wasn't for putting EMRs in place, if it wasn't for some of these shifts that have happened, you and I would still be, you know, battling this system that pays you no matter what. Right? And I think now is technology is a way that that can empower the average person to manage their own health. I'm not going to say optimally, but boy, a hell of a lot better than no information. I mean, at least some information can maybe give you an early warning light of something that you might be able to intervene in.And I don't know anybody that likes being sick. I mean, I don't do well when this thing starts to age a little bit and not function the way that I want it to. So I've tried to try and keep it in as good of a running condition as I can. So it lasts as long as possible. I mean, I'm one of those people that would listen if I just drop dead at 95, like just boom gone. I would be so happy. Right. As opposed to this sort of chronic  dynamic. [musical transition]Harry Glorikian: I want to pause the conversation for a minute to make a quick request. If you're a fan of MoneyBall Medicine, you know that we've published dozens of interviews with leading scientists and entrepreneurs exploring the boundaries of data-driven healthcare and research. And you can listen to all of those episodes for free at Apple Podcasts, or at my website glorikian.com, or wherever you get your podcasts.There's one small thing you can do in return, and that's to leave a rating and a review of the show on Apple Podcasts. It's one of the best ways to help other listeners find and follow the show.If you've never posted a review or a rating, it's easy. All you have to do is open the Apple Podcasts app on your smartphone, search for MoneyBall Medicine, and scroll down to the Ratings & Reviews section. Tap the stars to rate the show, and then tap the link that says Write a Review to leave your comments. It'll only take a minute, but it'll help us out immensely. Thank you! And now back to the show.[musical transition]So you mentioned AI, you mentioned machine learning. Where do machine learning and other forms of AI fit into January's service and you know, what do you do on consumer data? What kind of predictions can you make that wouldn't otherwise be possible?Noosheen Hashemi: Okay. I can first talk about exactly that. What did we do that hadn't been done before. What is really unique? What are we filling? So essentially in one word, it is prediction. You said it. So  as you know, there've been, there have been glycemic prediction models for type 1 diabetes, but type 1, as, you know, is a serious condition, which, you know, precision really matters for type one. It's life and death.But there hasn't been much done with type 2 diabetes. And so we set out to do predictions, for type 2 diabetes. And  the type 1 diabetes models are pretty simple. They basically are an insulin-carb calculus, essentially. But as we dug in, we realized that  you know, carbs are not all the same and that there are so many other factors besides carbs that affect glycemic response, including things like fiber fat and protein, water, and foods. We wanted to understand glycemic index and glycemic load of foods. So our major  machine learning  research projects, we basically did research for two and a half years before we sold anything.  One of the first things that we did was to try to understand the foods themselves. So we essentially built the largest database. Essentially we licensed all the, these curated food databases, and then we labeled the foods that didn't have food labels, because right now the only food labeling you really have is like grocery foods and chain restaurants.So we labeled foods and then, recognizing that glycemic response was better associated with glycemic index than carbs alone, we set out to create glycemic index and glycemic load for all these foods. Then we ran a clinical trial and associated people's glycemic response to the glycemic load of foods they were eating. And then we turned that into a prediction. So, the prediction model.  Why is it so cool? Well, why should you use your body to figure out how many glasses of wine is going to spike you? Why not have the AI tell you that? Why not do that in silico?  It's this weekend, you want to cook for your wife. You want to get her the right fried chicken recipe. Well, check those out in January, check out those recipes in January. If you know what the glycemic response of, of each one of those recipes could be, it really helps you compare foods. For kind of recipes you can comparefood items in your local cafe. You want to figure out what to eat. You don't have to put them through your body to figure out how you're going to respond, put them through the AI to figure out how you're going to respond.And then in terms of, you know, how we're different. I mean, we essentially live in the future. We, we don't  we don't live in blood pricks and strips and blood glucose meters. We kind of live in the CGM, HRM (heart rate monitor) precision foodworld. We've turned food into actionable health data, which is a necessary ingredient you need if you want to understand people's glycemic response. And if you want to be able to predict it, and that is our huge innovation that nobody has. And we have quite a bit of IP around it. There are a number of things that we're using. We're using meta-learning.  We're using  neural networks. I don't know how much I should say about what we're using. Yeah. We have one paper that we've put out, which is really, really, really simple.  But we, we always talk about, what kind of papers we want to put out and how much we should put out and how much should we not put out, but essentially you can look at the people that advise the company and you can see that, you know, we have a lot of expertise around  essentially… Harry Glorikian: But Noosheen, when you're doing this right, you need to, at some point, I think you need a baseline on say me for a certain period of time before the algorithm can then respond appropriately to that. And then doesn't that potentially change over time, time you mentioned the yogurt, the meusli, right.  And how that affects. So it's constantly gotta be in a feedback learning loop.Noosheen Hashemi: Yes. Yes. And the beauty of January is that essentially you don't have to wear a CGM 365 days out of the year. We think that with AI, we allow you to wear a CGM intermittently. So maybe you want to wear it every quarter  to update our models  just to see how things are going, but you don't need to wear it all the time. You can wear it for a period of training and then basically run your simulations in silico rather than through your body. Let the AI do the work. So you definitely should wear it intermittently so we can update our, our models because people do age. People do have inflection points in their health. They get pregnant, they travel, a lot of things change, but we don't think it's necessary for healthy people to wear CGMs all year long necessarily. Harry Glorikian: So now we're talking about consumer behavior, right, for a, for a tech product like this. And if, you know, if you look at some of the data that I've read in some of these papers, you know, the potential market is significant. It's, you know, it's quite large. I mean, if I just said, you know, 15% of the people have pre-diabetic levels of glucose after eating, that would translate to like 50 million people in the United States alone. But the service depends on the CGM, the app, the external heart monitor. It's, you know, users have to be diligent about monitoring and logging food intake and activities during the introductory month. So for a quantified self junkie, I get it. They're all over this.  What's the plan for getting everybody else on to this? Noosheen Hashemi: Well, I think it's all about the user experience. And I think we have a, we have a long way to go as an industry and for us as well.As a company we have, what we imagine to be the user experience is nowhere near where we are today.I'm old enough to remember world before Starbucks. So you would see ads on TV for MJB coffee, which is something you made at home. You know, I don't know if you remember that but Starbucks created a new experience, really a place between home and work where you would stop by for coffee.And so the outrage around the, you know, $3, $4 latteat the time, do you remember that?Well, Starbucks continue to improve the experience. They added wi-fi, they had ethical coffee, they had kind of a diverse employee population. People's initial wonder and worry gave way to this, you know, gigantic global brand. And I think all of that is because of the experience that people had. I think we need to make health a positive experience. We need to—we, including January—need to make health something that people….it's going to be a little clunky in the beginning, just like the old, you know, cell phones used to be. But while we're going through this process, the companies need to work on to improve the experience and people need to be patient with the clunkiness of everything  to get us to a place where these things become much, much more pleasant to use and easier to use, and essentially AI starts reading your mind about what you were eating and what you were doing. That is going to happen. You know, I've gotten so used to my Apple Watch now that I actually love it. It actually is doing a very good job training me. Just at the right time, you know, “Come on, you still have a chance. Let's go.” You know, all the things that it's doing  I'm actually liking it. It's it's enjoyable. Because it Is coaching. And I feel like the answer for mass adoption lives in experience. We need to improve the experience dramatically. Harry Glorikian: It's interesting though, because I I'm play with a lot of these different things and I noticed that depending on how they're designed, how they're put together, it nudges me to do that much more or et cetera. I don't always listen. Human beings don't always do what they're supposed to do for their better good. But  you can see how, when the app is designed in a way to nudge someone the right in through the right mechanisms. And that's the problem, right, is trying to—not the same mechanism works on everybody. So you may have to have multiple approaches that the system tries like AB testing for a website to, to get them to do that.But so, if the average person like me wants to do something like this, obviously I have to get a ‘script from my doctor, which just drives me crazy that I can't just—because I can buy a finger-prick, right, over the counter and poke myself a thousand times and then write down these numbers to see what happens. Which seems a little clunky in my opinion. But I can't buy the CGM that does it automatically. There's gotta be some medical person saying like, we're gonna make more money off this if we do this or do that, or, or it just doesn't make any sense to me.  How do you, how does January come at the expense reimbursement or the insured part of it, or is this just out of pocket for everybody? Noosheen Hashemi: Sure. So right now  government insurance, companies, and private insurance companies cover CGMs for people that are intense insulin users. So people that prick themselves four times a day. And so that's three and a half million out of 122 million people that have pre-diabetes or diabetes. So it's a very small population. And the rest is all cash paid. And it it's really out of pocket. So we have an early access price of $288. And we, you know, we include the CGM, but you can also buy CGMs only from January. You can just, if you just want a CGM, you don't want to do anything else. You're just curious. You want an introduction to this world? You can order a CGM from January for $80 if you want to do that. So if you're one of the 12 million people that are insured by Kaiser—and Kaiser doctors will not write you a prescription, you can go to your doctor and ask them, they won't write you a prescription—come to January. We will give you a CGM. You can be introduced to the program and then, you know, take, take up January from there and experience the magic of CGMs alone. I really do think they are a magical product because they they're showing you for the first time you kind of can see inside your body, which is really phenomenal. Unfortunately by themselves, they're not that effective and they're not that effective by themselves longitudinally. So if you really want to keep track of how you've been doing, what food spiked you, how you can, you know, what kind of exercise, things like that. They don't really have that additional intelligence, but they are magical, they are really magical tools. But, you know, you want an insightful experience on top of that. With the AI that can essentially synthesize this kind of data from your heart rate, monitor from your food, from your glucose monitor and sort of let you know how much to eat, what to eat, how to hack your food, how much to walk, how much, how much to fast, when to fast, how much fiber you're having, not having. That's where we come in. Harry Glorikian: I feel like at some point I'm going to need a big monitor in my house that just tells me these things as I'm walking by. But you know, it, it's interesting. I mean, we are entering the era of real wearables and apps and big data and, and, you know, but here's the question though. Soyou know, Apple just announced what's going to be the update to their iOS and, you know, pretty soon I'm going to be able to push a button and share data with my physician.  Which is funny because I go in his office and I pull up my phone and I'm like, here's my longitudinal. And here's my longitudinal. And I'm like, look, you can take the measurement because you're supposed to, but here's how it looks over the last three months as opposed to the one time when I'm here. Can January's customers export and share the data with their doctor? Noosheen Hashemi: We have a report  midstream at 14 days that you can share  with, with your doctor. But of course we intend to, you know, we have features planned that are going to make things way more easily done, much more easily in the future. We really strongly believe that people should own their own health data. We are huge advocates for people owning their own health data, because there are a lot of people hanging onto your health data and they don't want to give it to you. I'm talking about device makers and others. You're paying for the device, which comes with the data, but they don't want you to have the data. So they're like, “You can have the data and study it yourself, but you can't give that data to other people.” But that doesn't work.We are living in a multi-omics world. Single 'omics by themselves, the single side node biomarkers, you know, “Harry, you just manage your cholesterol. Noosheen, you can't keep two things in your head. Why don't you just manage your A1C? And Mike, you should watch your blood pressure.” That just doesn't work. There are many, many markers that you've just, as you just said, that we need to keep in our heads. We can't keep them in our heads, but that's where AI comes in. We need to feed them into something and people must have the right to own their data and share their data with whoever they want. If it's their coach, it's their doctor, it's their wife or spouse or significant other, their dog. They should be able to share the data that they own.As long as they provision it properly to whoever they want to give it to because you know, someone doesn't want their employer to know X, Y, and Z. Somebody else wants their coach to know that is people's rights. And coming from kind of a libertarian point of view, I really think people, you know, people should own their own data and they should be able to mix it with other data  for synthesis, if they want to. Harry Glorikian: Yeah, it's interesting. I mean, I totally believe in that. I always, I also understand that people may not understand the implications of sharing sometimes.  And that's not clear, but I do believe that the next iteration of where we're going to see this technology go is multifactorial software programs that can take a number of different inputs to give a much more holistic view of what's going on with me, so I can manage myself better share that information. My biggest worry is most physicians I know are—it's not totally like, it's not their fault, right….Noosheen Hashemi: They're so busy, so they're spending 15 minutes a year with you. And during that 15 minutes, you know, they're taking a point in time, you know, to see a snapshot of your health. And your health is way more complicated than that. We're talking about reverse engineering, 5 billion, years of evolution. And you know, they're going to get, see if such an infinite small part of that. We need to be way more self-aware.Harry Glorikian: Well, it's funny because I do have, some of my physician friends will be like, you want me to understand that genomic marker that whatever, like, I can't, I can't get my patient to manage their insulin level!Noosheen Hashemi: I have a lot of empathy for that. They just don't have the time.  I completely fully understand. Which is why I think we should carry more of the, we should have more agency over our health and we should carry the burden a little bit more.Harry Glorikian: So what is wild success for January? Noosheen Hashemi: Well, we want to keep on this path of developing our multi-omic platform. We want to essentially  help people understand themselves deeply and figure out how to dial their lifestyles and sort of tweak and tune their health. This is non-trivial obviously because there's not enough research in food science or enough research on prevention. You know, out of the $3.8 trillion that we spend on healthcare, 2.9% goes to prevention and 10% goes to acute care end of life care. Just think about that. More than three times as much goes to end of life acute care than goes to prevention. And I'm talking about healthcare costs, I'm not talking about research costs in terms of what NIH and USAID and all of those people spend. So there's not enough research that's happening. You know, people's health data is not organized today. I'm sure there are companies who are trying to organize the world's data. You know, the company that tries to organize the world's data is trying to organize your health data. So I think that's pretty smart.  I think today it's still very opaque and it lives in silos, but I think in the future is going to be mixed.  I think today people just aren't fully empowered yet, you know, with the knowledge and with the agency and with the tools they need to really manage their health.Wild success for us means that people, that we're part of this revolution of consumerized healthcare. We're part of the food-as-medicine revolution, the precision nutrition revolution. So we see ourselves coming up with tools that can essentially get amazing experiences in the hands of millions of people.If you can think about a company like Livongo going public with 192,000 patients. Or if you think about everyone that's playing in the metabolic health today, if you put 12 or 13 companies together, maybe they have a million users, or maybe a million and a half users. Where is that compared to 122 million people that have pre-diabetes diabetes and another a hundred million people that are optimizers? They're either wearing a wearable, they belong to a gym, they're on a diet. You have the entire population as your market. And we have very little that has really made a major foray into health. So wild success means having a product that becomes mainstream. Harry Glorikian: So I think what you're saying is January is moving beyond just CGMs and metabolic syndrome, right?Noosheen Hashemi: Absolutely. Yeah, we, we imagine ourselves, we have built an expandable platform. Our goal is to keep doing deep phenotyping. So we will add 'omics  you will see us adding 'omics beyond what we have today. You will see us  get to other cardio-metabolic disease, you know, cardiometabolic disease, essentially going beyond metabolic disease to the rest ofmetabolic syndrome. You'll see us be ahardware-agnostic company. We want to essentially let people wear whatever they want.  Whatever works for them and, and still try to bring that data, synthesize it and make sense of it and feed it back to them so they can take action. Harry Glorikian: Excellent. Well, that's, that's a great way to end the program with. We have so much more to see from the company and what it's going to be able to do with the data and, and, and help  you know, people live a healthier life. Or like I said, with me I'm constantly trying to measure what's going on. It's just distilling it to make it easily consumable to do what I need to do rather than have me learn statistics so that I can figure it out. Noosheen Hashemi: We have to get, all of us need to get better than that. I remember when I first put on my Oura ring, you know, there's, you know, most people  first when they wear their Fitbits, you know, first it was like, how much did I sleep? And then they kind of learned about REM and sort of deep sleep and then slowly. And then Oura came and then it was like, oh, and Whoop had already had heart rate variability, but then, you know, Oura came in with their other markers, you know, restfulness. And efficiency, sleep efficiency and timing, et cetera. And so people are slowly wrapping their heads around this. It takes a little whil. And yes, January gives you a lot of levers. You know, there's fasting, there's fiber, there's calorie management. There's you know, the spikers. There is the activity counterfactuals—I ate this, but had I eaten this other thing, this would have been my glycemic response. Or had I walked X number of minutes after that, this would have been my glycemic response. At the beginning it's a lot, but that's where it goes back to the experience. We must make the experience enjoyable and better, and we must, companies like us should strive to make the experience enjoyable, make them fantastic consumer experiences like Apple products. But remember Apple's 45 years old and we're just getting going with this, But [Apple is] a great role model. Harry Glorikian: Wellyou know, my doctor may not like it, but I may have to get one of these. He's listening to this podcast. I know that he will, because he always comments on them. Noosheen Hashemi: We're definitely doing that. And you know what? You can have Mike Snyder, you can chat with Mike  about your numbers after. That would be a lot of fun.Harry Glorikian: Excellent. Oh, I look forward to it. So thank you so much for participating. Noosheen Hashemi: Thank you, Harry. It was pleasure.Harry Glorikian: That's it for this week's show. You can find past episodes of MoneyBall Medicine at my website, glorikian.com, under the tab “Podcast.” And you can follow me on Twitter at hglorikian.  Thanks for listening, and we'll be back soon with our next interview.

The Real Cause of Alzheimer's and Dementia and How to Prevent Them | This episode is brought to you by BLUblox.A declining mind is one of the scariest things I can imagine. Left unchecked, I've seen the devastating effects this process can have on individuals and their families. But we now know there is so much that can be done to prevent and even reverse Alzheimer's and dementia and save people from a foggy future. I know some of you may have had to reread that—yes, Alzheimer's reversal is real. The latest research is showing some amazing results that give us a new perspective of hope, even (or especially) if you're genetically predisposed. Today on The Dhru Purohit Podcast, Dhru talks to Dr. David Perlmutter about the latest findings in the field of Alzheimer's and dementia. Dr. Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. Dr. Perlmutter received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer's Disease and has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition. Dr. Perlmutter's books have been published in 32 languages and include the #1 New York Times bestseller Grain Brain, The Surprising Truth About Wheat, Carbs and Sugar, with over 1 million copies in print. Other New York Times bestsellers include Brain Maker, The Grain Brain Cookbook, The Grain Brain Whole Life Plan, and Brain Wash, co-written with Dr. Austin Perlmutter. His latest book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases, and will be published in February, 2022.In this episode, we dive into:-Dr. Dale Bredesen's study showing that Alzheimer's disease is reversible (9:13) -What contributes to Alzheimer's disease (11:31) -Blood sugar dysregulation and fructose (18:43) -How our gut bacteria is responsible for regulating our metabolism (22:04) -What threatens our gut bacteria (41:17) -The importance of diversity in our gut (46:30) -Dr. Perlmutter's diet (51:38) -How elevated uric acid levels lie at the root of many pervasive health conditions (56:45) -How to test for uric acid levels (1:08:59) -Foods that are high in uric acid (1:11:38) For more on Dr. David Perlmutter, you can follow him on Instagram @DrDavidPerlmutter, on Facebook @DavidPerlmutterMD, on Twitter @DavidPerlmutter, on Youtube @DavidPerlmutterMD, and through his website https://www.drperlmutter.com/. Check out his podcast The Empowering Neurologist at https://www.drperlmutter.com/learn/empowering-neurologist/. Preorder his book, Drop Acid: The Surprising New Science of Uric Acid—The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health at https://www.amazon.com/Drop-Acid-Surprising-Controlling-Extraordinary/dp/0316315397Also mentioned in this episode:-Precision Medicine Approach to Alzheimer's Disease: Successful Proof-of-Concept Trial - https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v1-The Science of Prevention Docuseries - https://scienceofprevention.com/-The End of Alzheimer's Program by Dr. Dale Bredesen - https://www.apollohealthco.com/book/the-end-of-alzheimers-program/For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 200-5643 or click here https://my.community.com/dhrupurohit.Sign up for Dhru's Try This Newsletter - https://dhrupurohit.com/newsletter.Interested in joining The Dhru Purohit Podcast Facebook Community? Submit your request to join here: https://www.facebook.com/groups/2819627591487473/.This episode is brought to you by BLUblox.As someone who is on the computer a lot, I realized all that screen time was negatively affecting how well I slept. I started learning about blue light and how it disrupts the body's natural melatonin production, so I decided to try blue-light blocking glasses throughout the day to see if they helped—and they totally did. I love the blue-light blocking glasses made by BLUblox. BLUblox glasses reduced my digital eye strain and dramatically improved my sleep, and I have more energy throughout the day. Right now BLUblox is offering my listeners 20% off, just go to blublox.com/dhru and use code DHRU at checkout. See acast.com/privacy for privacy and opt-out information.

Did you know 1 in 10 Americans have diabetes and 1 in 3 are pre-diabetic? In this episode, we discussing simple ways of controlling blood sugar.