Podcasts about vasculature

In this week's episode, we'll hear about how researchers look toward the lung, and find uniquely programmed blood stem cells. This study is the first to fully characterize hematopoietic stem and progenitor cells in the adult human lung. After that: researchers develop a neural network-based probabilistic classifier, DLBclass, that assigns all diffuse large B-cell lymphomas into one of five genetic subtypes. It's an inclusive taxonomy that they say provides actionable genetic information in almost all patients with DLBCL. Finally, new insights on NETS, or neutrophil extracellular traps. In the liver vasculature, NET removal leads to secondary inflammation, resulting in new waves of NETS that may impact future infection. We'll review these and other findings from this recent mouse model study.Featured Articles:Decoding functional hematopoietic progenitor cells in the adult human lungDLBclass: a probabilistic molecular classifier to guide clinical investigation and practice in diffuse large B-cell lymphomaDonor regulatory T-cell therapy to prevent graft-versus-host disease

Download for FREE today -  special Mnemonics Cheatsheet - so you can be SURE that you have that Must Know information down:  bit.ly/nursing-memory   Outline 2A 1V 2A-Two Areolas, Two Arteries 1V-One Vagina, One Vein Description To remember the vasculature in the umbilical cord, remember that the mom has: Two areolas; One Vagina. So, there are Two umbilical arteries, one umbilical vein.

One of the more common questions I get asked, as it relates to red light therapy, is how is it different than infrared saunas? Do they elicit the same health benefits? Which one is "better"? If I had to choose one, which modality should I use? Understandably, the major hangup and confusion comes from both technologies integrating infrared light... granted of different flavors of infrared and, thus, different physiological responses.We cover the basics of what infrared saunas are, the difference between traditional vs. infrared saunas, discuss the ​top 10 benefits derived from consistent hyperthermia treatment and more. Possibly, most importantly, I delineate the differences between infrared saunas and red light therapy and emphasize the importance of not doing red light therapy and sauna simultaneously! This is especially important to understand and appreciate, as I have seen more and more often that infrared sauna companies are incorporating red light therapy (either for ambience lighting and/or actual red light therapy panels and other devices inside of the sauna). Long story short: the heat from the sauna inhibits the benefits you would otherwise obtain from red light therapy. ​​ Lastly, we will cover a very, very hot-off-the-press photobiomodulation research article that looks at red light therapy for treating children with premyopia. In a world with exponentially increased screen time, particularly in youths, any type of alternative modality to help prevent, stave off and reverse eye and vision issues ​is a massive deal. If you have eyes, this study has some groundbreaking results that you will want to learn about. I hope you enjoy the information in today's solosode. Please share this episode with family, friends and colleagues if you find the content especially interesting and/or impactful.​​ As always, light up (and sweat out) your health! - Introduction and Weather Update (00:00:00): Dr. Mike Belkowski welcomes listeners to another episode of the Red Light Report. Mentions cold weather in Montana, ranging from -20 to -30 degrees. Talks about the coziness of his surroundings during the recording. Sauna and Red Light Therapy Discussion (00:00:26) - 00:02:35): Dr. Mike discusses his recent activities, including sauna and red light therapy. Announces a focus on the differences between infrared saunas and red light therapy in this episode. Expresses the need to clarify the topic for new followers. Infrared Sauna Overview (00:03:00) - 00:08:42): Dr. Mike delves into infrared saunas, emphasizing the use of far infrared light. Advises seeking third-party testing for companies claiming full spectrum infrared light. Highlights the importance of understanding the intensity of near-infrared light. Benefits of Infrared Saunas (00:08:42:25 - 00:17:48:13): Explains the benefits of infrared saunas, including heart health, detoxification, and athletic recovery. Discusses the role of far infrared rays in penetration and detoxification. Explores the impact on growth hormone levels, arthritic and muscular pain relief, and muscle gain/fat loss. Mentions the potential increase in muscle regrowth through intermittent hyperthermia. Far Infrared Saunas Overview (00:08:42:25 - 00:09:11:15): Dr. Mike emphasizes that infrared saunas predominantly use far infrared light, operating at lower temperatures compared to traditional saunas. Far infrared rays penetrate the skin deeply, leading to improved circulation, relaxation, and potential detoxification through sweat Benefits of Far Infrared Saunas (00:09:11:17 - 00:10:51:29): Dr. Mike elaborates on the top reasons and benefits of using infrared saunas. Heart Health and Longevity Detoxification Athletic Recovery Arthritic and Muscular Pain Relief (00:12:36:14 - 00:17:24:02): Dr. Mike discusses the positive impact of infrared sauna on pain relief and increased mobility Sauna-induced pain relief Increased flexibility of collagen-based tissues (tendons, fascia, joint capsules) at higher temperatures Muscle Gain and Fat Loss (00:18:24:45 - 00:19:34:58): Dr. Mike explores how saunas can promote muscle growth and fat loss. Improved insulin sensitivity and reduced muscle protein breakdown are linked to sauna sessions. Reduced insulin resistance and increased muscle growth and weight control Human Growth Hormone (HGH) and Heat Shock Protein Synthesis (00:19:35:01 - 00:27:43:58): Dr. Mike emphasizes the benefits for athletes and exercise enthusiasts, citing the release of Human Growth Hormone (HGH) during sauna sessions. Increased expression of heat shock protein synthesis is discussed as a secondary benefit. These proteins help spare muscles during periods of reduced exercise or stress Immune System Boost (00:19:59:11 - 00:21:04:33): Dr. Mike refers to a study in the Journal of Human Kinetics, which investigated the effects of saunas on the immune system. Sauna sessions were found to increase the number of white blood cells, lymphocytes, and basal cell counts, stimulating the immune system German medical research suggests that saunas can significantly reduce the incidence of colds and influenza. Regular sauna use and sunbathing are associated with a 30% lower chance of getting a cold or influenza Skin Rejuvenation (00:21:05:15 - 00:21:34:20): Replacing dead skin cells and removing bacteria from the skin and sweat ducts Increased capillary circulation, giving the skin a softer, younger appearance and reducing wrinkles Relaxation and Better Sleep (00:21:34:23 - 00:22:43:39): Sauna use is linked to deeper, more relaxed sleep and relief from chronic tension and fatigue Increased Cardiovascular Performance (00:22:43:41 - 00:23:47:43): Post-exercise sauna treatment for 31 minutes is shown to increase oxygen consumption and red blood cell production. Sauna-induced heat leads to increased cardiac output, contributing to improved cardiovascular performance. Increased Stress Resilience (00:23:48:16 - 00:24:21:19): Sauna-induced hypothermia triggers the production of heat shock proteins, preventing protein degradation and muscle loss. Heat shock proteins play a crucial role in cellular stress response, promoting stress resistance, preventing free radical damage, and supporting cellular antioxidant capacity. Heat Shock Proteins and Cellular Benefits (00:24:21:21 - 00:27:09:34): Dr. Mike delves into the specific benefits of heat shock proteins, including cellular repair and protection, anti-inflammatory effects, stress adaptation, improved cellular function, cardiovascular health, and detoxification. Sauna Usage Frequency and Red Light Therapy (00:27:09:36 - 00:30:59:36): Dr. Mike shares his sauna usage frequency, emphasizing the motivation for exercise enthusiasts and the benefits discussed earlier. He highlights the importance of not combining infrared sauna sessions with red light therapy, as the heat from the sauna may inhibit the benefits of red light therapy. Dr. Praveen Irani's insights on this topic are referenced, suggesting that separating these treatments is crucial for maximizing their benefits. Red Light Therapy and Saunas (00:30:59:39 - 00:31:28:04): Emphasizes not combining red light therapy and saunas, citing potential issues. Difference Between Infrared Saunas and Red Light Therapy (00:31:28:06 - 00:31:58:28): Discusses the physiological impact on mitochondria. Benefits of Red Light Therapy on Mitochondrial Function (00:31:59:04 - 00:32:28:27) Red light therapy improves mitochondrial function. Impact of Modern Lifestyles on Mitochondria (00:32:28:30 - 00:32:55:40) Lack of consistent exposure to sunlight affects cytochrome C oxidase. Nitric Oxide and Oxygen Dynamics in Mitochondria (00:32:55:42 - 00:33:22:41) Explains how nitric oxide affects oxygen entry. Link Between Mitochondrial Function and Overall Health (00:33:22:47 - 00:33:49:52) Comparison of Infrared Saunas and Red Light Therapy (00:33:49:52 - 00:34:19:30) Choosing Between Sauna and Red Light Therapy (00:35:26:26 - 00:35:57:00) Frequency of Use (00:35:57:03 - 00:36:28:18) Preference for Red Light Therapy (00:37:14:04 - 00:37:48:14) Recent Study on Red Light Therapy for Myopia Control (00:37:48:16 - 00:38:18:13) Study Methodology (00:38:18:15 - 00:38:37:02) Findings (00:39:59:20 - 00:40:48:29) Highlights the study's findings of increased choroid thickness and flow. Conclusion (00:41:27:04 - 00:42:03:53) Emphasizes the significance of the study's results but calls for further research. Advocacy for Low-Level Red Light Therapy Devices (00:42:37:14 - 00:43:05:36) Recommends considering devices like the BioLight Glow for low-dose red light therapy benefits. Closing Thoughts (00:53:51:01 - 00:54:41:09): Dr. Mike expresses excitement about ongoing research and encourages the proactive use of red light therapy. - Article Referenced in Episode: The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia - Methylene blue is considered to be one of the —  if not THE  —  best antiviral around. Especially during the winter season, proactively using methylene blue could be one of the best options to ward of viruses and illness. It should be in everyone's toolkit!BioBlue not only utilizes the purest-sourced pharmaceutical grade methylene blue available, but it is also includes NMN to boost mitochondrial support and silver and gold colloidal for photodynamic properties with red light therapy, amongst other benefits. Save 15% on your BioBlue order! Use coupon code "BioBlue15" - Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Instagram YouTube Facebook

Join me, your host Dr. Mike T Nelson, and my special guest Dr. David Church on the Flex Diet Podcast as we embark on an enlightening exploration of muscle protein, testosterone, and exercise. We share our personal experiences and discuss the role of vasculature in muscle growth, the impact of exercise on protein metabolism, and the potential downsides of perfect nutrition. Our conversation even ventures into the realm of testosterone's role in muscle growth and its potential anti-catabolic effects. Hear first-hand insights from Dr. Church's research on the use of essential amino acids and the impact of testosterone on highly catabolic burn patients. If you enjoyed this podcast, you can get more from me at MikeTNelson.com/podcast. You can see all the other podcasts and guest episodes I've done. Then if you scroll down, you can subscribe to my Fitness Insider Newsletter.Episode Chapters:(0:00:01) - Protein Training, Testosterone, and Muscle Growth(0:06:55) - Muscle Contraction and Oxygen Consumption(0:19:20) - Importance of Aerobic Conditioning and Warm-Up(0:26:07) - Balancing Warm-Ups, Safety, and Fitness(0:30:46) - Military Injuries and Training(0:41:31) - Testosterone and Muscle Protein Synthesis(0:52:18) - Testosterone and Muscle Protein Turnover Effects(1:06:13) - Supplement Hierarchy and ConsiderationsConnect with Dr. Church:X (formerly Twitter)InstagramAbout Dr. Church" Dr. David Church is a physiologist and muscle biologist with over 50 peer-reviewed publications and multiple invited talks at regional, national, and international conferences. He obtained his bachelor's degree in exercise science and biochemistry from DePauw University where he also played varsity football and baseball. Following this, he was an athletic performance intern at Baylor University where he also studied exercise and nutritional biochemistry. He obtained his PhD from the University of Central Florida with a focus on how to enhance human performance through exercise and nutrition." 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.11.548482v1?rss=1 Authors: Jukkola, J., Kaakinen, M., Singh, A., Moradi, S., Ferdinando, H., Myllyla, T., Kiviniemi, V., Eklund, L. Abstract: Abstract Background Inside the incompressible cranium, the volume of cerebrospinal fluid (CSF) is directly linked to blood volume: a change in either will induce a compensatory change in the other. Vasodilatory lowering of blood pressure has been shown to result in an increase of intracranial pressure, which, in normal circumstances should return to equilibrium by increased fluid efflux. In this study, we investigated the effect of blood pressure lowering (BPL) on fluorescent CSF tracer absorption into the systemic blood circulation. Methods BPL was performed by an i.v. administration of nitric oxide donor sodium nitroprusside (5 g kg-1 min-1) or the Ca2+-channel blocker nicardipine hydrochloride (0.5 g kg-1 min-1) for 10 and 15 to 40 mins, respectively. The effect of BPL on CSF clearance was investigated by measuring the efflux of fluorescent tracers (40 kDa FITC-dextran, 45 kDa Texas Red-conjugated ovalbumin) into blood and deep cervical lymph nodes. Results Nicardipine and sodium nitroprusside reduced blood pressure by 32.0 {+/-} 19.6% and 22.0 {+/-} 2.5%, while temporarily elevating in intracranial pressure by 14.0 {+/-} 6.0% and 11.6 {+/-} 2.0%, respectively. BPL significantly increased tracer accumulation into deep cervical lymph nodes and systemic circulation, but reduced perivascular inflow along penetrating arteries in the brain. The enhanced tracer efflux by BPL into the systemic circulation was markedly reduced (-66.7%) by ligation of lymphatic vessels draining into deep cervical lymph nodes. Conclusions This is the first study showing that CSF clearance can be improved with acute hypotensive treatment and that the effect of the treatment is reduced by ligation of a lymphatic drainage pathway. Enhanced CSF clearance by BPL may have therapeutic potential in diseases with dysregulated CSF flow. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

References Inn Med (Heidelb). 2023 Apr;64(4):313-322 JBC 2001.Volume 276, Issue 31, Pages 28799-28805 Frein, Daniel. 2006. “Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide.” Hypertension. 2002;39:1088–1094 Nat Metab. 2022 Sep;4(9):1202-1213 JCI Insight. 2016 Nov 17; 1(19): e87748 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

In this episode, we chat with Dr. Guillermo Oliver.  Guillermo Oliver is a Uruguayan-American research scientist. He is currently the Thomas D. Spies Professor of Lymphatic Metabolism at Northwestern University, and director of the Center for Vascular and Developmental Biology at the

In this episode, we chat with Dr. Guillermo Oliver.  Guillermo Oliver is a Uruguayan-American research scientist. He is currently the Thomas D. Spies Professor of Lymphatic Metabolism at Northwestern University, and director of the Center for Vascular and Developmental Biology at the Feinberg Cardiovascular Research Institute. Oliver is an elected member of both the American Association for the Advancement of Science and the Academia de Ciencias de América Latina. One of Oliver's research focuses has been the lymphatic vasculature, and his laboratory demonstrated that Prox1 activity was required for the differentiation of lymphatic endothelial cells and the formation of the entire lymphatic vasculature.[9][10] They later showed the role of lymphatic vasculature on obesity.[11][12] His laboratory also identified Six2 as a critical gene in the process of generation of nephron progenitors[13] and demonstrated that Six3 activity was required for the formation of the mammalian forebrain and neuroretina in mice.[14][15] He expanded those results using embryonic stem cells and induced pluripotent stem cells to generate eye organoids that mimic early eye development.[8] In 2020, he published his research on the role of the Reelin protein promotes cardiac regeneration and repair by reducing cell death after heart injury in the journal Nature.[16][1 (Bio reference: Wikipedia) Highlights of this podcast include: What is Lymphatics Removal of toxins Immune response Lymphedema Weight gain and lymphatics Obesity and lymphatics Meningeal lymphatics Cardiac repair Lymphatics and organ growth Comorbidity Diet and lymphatics Crohns, IBS and lymphatics Lipedema And so much more... To learn more about Guillermo Oliver, visit @NU_Lymphatics on Twitter or on the Northwestern Medicine website and bio.  Reference: The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease. 

Dr Glenn McConell chats with Professor Katrien de Bock from ETH Zürich - Swiss Federal Institute of Technology. We discussed how exercise training increases blood vessels in skeletal muscle. Also muscle cells and blood vessels in regards to injury/repair and cancer. We also discussed exercise and leucine sensitivity. 0:00. Introduction 2:00. What is the vasculature. Blood vessels Endothelial cells etc 5:46. Redirecting blood to the muscle during exercise 7:16. Exercise training increases blood vessels in muscle 8:50. Exercise also improves blood vessel function 10:13. How does exercise increase muscle blood vessels? Called angiogenesis. It appears there is either sprouting or splitting into two. Not clear still. 14:32. Does every study you do work? Need resilience. “Negative data”. 19:06. Types of cells in blood vessels/ cell cross talk Satellite cells, white blood cells etc. 21:05. Muscle repair and blood vessel cells Timing important. Anti inflammatories 24:20. Too many anti inflammatories not ideal For adaptations to exercise and muscle repair. 24:44. Exercise blood flow stimulates blood vessel growth/angiogenesis Also vascular endothelial growth factor. 27:07. Hypoxia inducible factor 1 alpha (HIF1a) Exercise is an adaptive response to stress 29:28. Endothelial cells differ between organs The experimental models that she uses. Metabolically active endothelial cells. 33.17. Different types of exercise and blood vessel growth 35:35. Blood vessels and satellite cells 37:30. The importance of cell, animal and human studies 38:35. Keep eyes open to collaborations from left field Serendipity and persistence. Apold1. 43:07. Blood flow restriction/iliac artery endofibrosis 46:27. Exercise and leucine sensitivity Timing of protein intake after exercise not important. Anabolic resistance. 50:45. Takeaway messages 52:40. Exercise, cancer and blood vessels etc 54:34. Outro (9 seconds) Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: glenn.mcconell@gmail.com Subscribe to Inside exercise: Spotify: https://open.spotify.com/show/3pSYnNSXDkNLH8rImzotgP?si=Whw_ThaERF6iIKwxutDoNA Apple Podcasts: https://podcastsconnect.apple.com/my-podcasts/show/inside-exercise/03a07373-888a-472b-bf7e-a0ff155209b2 Google Podcasts: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy84ZTdiY2ZkMC9wb2RjYXN0L3Jzcw Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/4025218

Do you also want to pull out your hair when you learn about the pelvic vasculature? For this after Thanksgiving episode, we try to calm those feelings with a brief meditation while learning the pelvic blood vessels.  Twitter: @creogsovercoff1 Instagram: @creogsovercoffee Facebook: www.facebook.com/creogsovercoffee Website: www.creogsovercoffee.com Patreon: www.patreon.com/creogsovercoffee You can find the OBG Project at: www.obgproject.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.28.513298v1?rss=1 Authors: Nguyen Ngoc, K. V., Sai, S., Jun, Y., Bender, R. H. F., Kravets, V., Zhu, H., Hatch, C. J., Schlichting, M., Gaetani, R., Mallick, M., Hachey, S. J., Christman, K., George, S. C., Hughes, C. C., Sander, M. Abstract: Blood vessels play a critical role in pancreatic islet health and function, yet current culture methods to generate islet organoids from human pluripotent stem cells (SC-islets) lack a vascular component. Here, we engineered 3D vascularized SC-islet organoids by assembling SC-islet cells, human primary endothelial cells (ECs) and fibroblasts both in a non-perfused model and a microfluidic device with perfused vessels. Vasculature improved stimulus-dependent Ca2+ influx into SC-{beta}-cells, a hallmark of {beta}-cell function that is blunted in non-vascularized SC-islets. We show that an islet-like basement membrane is formed by vasculature and contributes to the functional improvement of SC-{beta}-cells. Furthermore, cell-cell communication networks based on scRNA-seq data predicted BMP2/4-BMPR2 signaling from ECs to SC-{beta}-cells. Correspondingly, BMP4 augmented the SC-{beta}-cell Ca2+ response and insulin secretion. These vascularized SC-islet models will enable further studies of crosstalk between {beta}-cells and ECs and can serve as in vivo-mimicking platforms for disease modeling and therapeutic testing. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Judy talks to Dr. Mike Serle about the recent AVA Scientific meeting and discusses the CKD population.The Association for Vascular Access would like to thank Medtronic for sponsoring this episode.Support the show

Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on vascular pathology in familial Alzheimer disease, and so much more. Tune in for a riveting episode!  Sections in this episode:  Cardiovascular Risk Factors (4:06)  Interactions of Vascular Pathology with AD Hallmarks (6:58)  Vascular Abnormalities in Familial AD (12:28)  APOE, Retinal Imaging, and Proteomics (18:12)  Treatments Targeting the Vasculature (23:22) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1S5T16qg9x-ERr9_UlcOq0BZCsTYmG6Vr/view?usp=sharingTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: www.amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook:  AMiNDR  Youtube: AMiNDR PodcastLinkedIn: AMiNDR PodcastEmail: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Elyn Rowe, edited by Chihiro Abe, and reviewed by Cassi Friday and Judy Cheng. The bibliography and wordcloud were both created by Sarah Louadi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For June 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Naila Kuhlmann, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Lara Onbasi for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode covering papers published on PubMed in February 2022.  Sections in this episode:  Clinical Insights: Neuroimaging and Vascular Risk Factors (3:51)  Preclinical Insights: Methodology and BBB Regulation (25:47)  Treatment Avenues (32:19) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1aIJ8ozysRXQpKlsoAueUnVlr4gtSjUtZ/view?usp=sharingTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: www.amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook:  AMiNDR  Youtube: AMiNDR PodcastLinkedIn: AMiNDR PodcastEmail: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Elyn Rowe, edited by Chihiro Abe, and reviewed by Cassi Friday and Ellen Koch. The bibliography was made by Anjana Rajendran and the wordcloud was created by Lara Onbasi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For February 2022, the sorters were Sarah Louadi, Christy Yu, Ben Cornish, Eden Dubchak, Vrishali Salian, Kira Tosefsky, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Lara Onbasi for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

Lifespan with Dr. David Sinclair ✓ Claim Podcast Notes Key Takeaways The paradox of living longer: our brain ages slower than the rest of our body but because modern medicine has helped us live longer, more people are living with cognitive decline, Alzheimer's and dementiaRead the full notes @ podcastnotes.orgIn this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: (00:00:00) Introducing Episode Seven: Aging of the Brain (00:04:39) Thanking the Sponsors (00:07:38) Ex-differentiation as a Driver of Aging (00:09:22) The Brain Ages Slowly (00:14:17) Cognitive Function and Plasticity (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins (00:23:26) Plant-based Diets and B-vitamins (00:28:32) Homocysteine, Plaque, and Vasculature (00:32:35) Fatty Acids (00:35:48) Physical Activity (00:39:14) Metformin (00:46:02) NAD Boosters (00:50:33) Increasing Blood Flor (00:53:20) Sleep (00:58:02) Overall Message: Keep your Brain Healthy (00:58:50) Next Week's Episode and the Future of Medicine (01:01:21) Options for Subscription for Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Dr. Mingxia Gu is an Assistant Professor of Pediatrics at Cincinnati Children's Hospital. Her lab's goal is to develop novel therapies for the regeneration of the heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. She talks about developing lung organoids to study COVID-19, how multi-lineage organoids can mimic human tissues, and her lab's motto to "move fast and break things."

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: (00:00:00) Introducing Episode Seven: Aging of the Brain (00:04:39) Thanking the Sponsors (00:07:38) Ex-differentiation as a Driver of Aging (00:09:22) The Brain Ages Slowly (00:14:17) Cognitive Function and Plasticity (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins (00:23:26) Plant-based Diets and B-vitamins (00:28:32) Homocysteine, Plaque, and Vasculature (00:32:35) Fatty Acids (00:35:48) Physical Activity (00:39:14) Metformin (00:46:02) NAD Boosters (00:50:33) Increasing Blood Flor (00:53:20) Sleep (00:58:02) Overall Message: Keep your Brain Healthy (00:58:50) Next Week's Episode and the Future of Medicine (01:01:21) Options for Subscription for Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Please fill out the survey! https://forms.gle/xRWFksZkgodAa3hE8 Ally and Ned talk about hysterectomies, a common gynecological procedure on OBGYN rotations. Intro (0:15), Vasculature (2:40), Ligaments (9:03), Ureters (13:38), Surgical Snippets (16:08)

Arthur de Lima Silva and colleagues present a hypothesis of floral evolution for the family, illustrating a shift from bisexuality to unisexuality and the evolution of nectaries in a complex monocot family, which can contribute to future studies on reproductive biology and floral evolution in other groups. You can read the post at https://www.botany.one/2021/11/floral-development-and-vasculature-of-eriocaulon-eriocaulaceae/ You can read the original article at https://doi.org/10.1093/aob/mcab100

Interested in how the 700km of blood vessels in the brain are linked to Alzheimer disease? Turns out there are a lot of common threads! In this episode, Elyn covers a series of clinical and preclinical papers exploring vascular risk factors, genetic risk factors like APOE, and signs of vascular damage that are linked to Alzheimer disease. Tune in for an exciting perspective on Alzheimer disease, outside of the classic amyloid cascade hypothesis!   Sections in this episode:  Clinical Studies: Cardiovascular Risk Factors and Cerebrovascular Pathology  (4:22)  Lymphatic/Glymphatic Drainage (13:48)  Preclinical Modelling (17:13)  -------------------------------------------------------------- You can find the numbered bibliography for this episode by clicking here, or the link below:https://drive.google.com/file/d/1D5gk0AJn1USNw2hBXXL4MIxX_D4tF4NB/view?usp=sharingTo access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can also join our mailing list to receive a newsletter by filling this form. Or tweet at us: @AMiNDR_podcast  --------------------------------------------------------------Follow-up on social media for more updates!Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastYoutube: AMiNDR PodcastLinkedIn: AMiNDR PodcastIf you have any questions or concerns, do not hesitate to contact us at: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more researchers is by leaving us a review on Apple Podcasts or wherever you listen to podcasts. It helps us a lot and we thank you in advance for leaving a review! Every episode of AMiNDR is the result of a huge team effort. Today's episode was scripted and hosted by Elyn Rowe, edited by Chihiro Abe, and reviewed by Jacques Ferreira and Ellen Koch. The wordcloud (wordart.com) was generated by Sarah Louadi and the bibliography was created by Jacques Ferreira. Big thanks to the sorting team for sorting all the papers published in July into themes for our episodes: Jacques Ferreira, Elyn Rowe, Ellen Koch, Christy Yu, Nicole Corso, Sarah Louadi, and Naila Kuhlmann. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alzheimer disease, and a bonus inclusion of a fluid biomarkers paper on the plasma lipidome!  Sections in this episode:  Clinical Studies – Neuroimaging and Cardiovascular Risk (4:20)  Mechanistic Studies – BBB dysfunction and rescue (13:20)  Bonus paper on Plasma lipidome (17:38) -------------------------------------------------------------- To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can also join our mailing list to receive a newsletter by filling this form. Or tweet at us: @AMiNDR_podcast  --------------------------------------------------------------Follow-up on social media for more updates!Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastYoutube: AMiNDR PodcastLinkedIn: AMiNDR PodcastIf you have any questions or concerns, do not hesitate to contact us at: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more researchers is by leaving us a review on Apple Podcasts or wherever you listen to podcasts. We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Elyn Rowe, edited by Michelle Grover, and reviewed by Jacques Ferreira and Anusha Kamesh. The bibliography was created by Tarini Boparai and the wordcloud (wordart.com) was generated by Sarah Louadi. Big thanks to the sorting team for sorting all the papers published in June into themes for our episodes: Jacques Ferreira, Elyn Rowe, Ellen Koch, Christy Yu, Nicole Corso, Sarah Louadi, and Naila Kuhlmann. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD that's outside of the amyloid cascade hypothesis! Sections in this episode:Overlap Between Cardiovascular Disease and AD (3:56)Clinical Studies on Cerebrovascular Pathology (12:20)Microvascular and Blood-Brain Barrier Changes in AD (16:03) ------------------------------------------------------------- PLEASE  FILL OUR SURVEY  TO HELP US IMPROVE OUR PODCAST, AND ENTER A DRAW FOR A $30 GIFT CARD.  Link if you prefer to copy/paste: https://amindr.hostedincanadasurveys.ca/417377?lang=enREGARDLESS OF THE DRAW, YOU WILL ALSO HAVE OUR ENDLESS GRATITUDE & THE SATISFACTION OF KNOWING YOU CONTRIBUTED TO THE BETTERMENT OF THE WORLD.-------------------------------------------------------------- Find the bibliography for this episode here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can also join our mailing list to receive a newsletter by filling this form. Or tweet at us: @AMiNDR_podcast  --------------------------------------------------------------Follow-up on social media for more updates!Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastYoutube: AMiNDR PodcastLinkedIn: AMiNDR PodcastIf you have any questions or concerns, do not hesitate to contact us at: amindrpodcast@gmail.com  -------------------------------------------------------------- Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more researchers is by leaving us a review on Apple Podcasts or wherever you listen to podcasts. We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Elyn Rowe, reviewed by Courtney Kloske and edited by Michelle Grover and Ellen Koch. The bibliography was created by Sarah Louadi who also generated the wordcloud on www.wordart.com. Big thanks to the sorting team for sorting all the papers published in May into themes for our episodes: Jacques Ferreira, Elyn Rowe, Ellen Koch, Christy Yu, Nicole Corso, and Naila Kuhlmann. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

Tired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping out cerebrovascular damage across the AD continuum. This is a shorter episode, with only 13 papers covered - perfect for a commute to work or a leisurely bike ride!   Sections in this episode:  Overlap Between Cardiovascular Disease and AD (3:48)  Clinical Studies on Cerebrovascular Pathology (12:03)  Mechanisms of Blood-Brain Barrier Disruption (18:00)  AD Treatments Targeting the Vasculature (21:14)   -------------------------------------------------------------- You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can also join our mailing list to receive a newsletter once per month by filling this form. Or tweet at us: @AMiNDR_podcast  --------------------------------------------------------------We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback form here:    https://forms.gle/5aq2JyrT6g4P1m8v6 You can also share your thoughts and suggestions by contacting us:  Email: amindrpodcast@gmail.com  Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastYoutube: AMiNDR Podcast-------------------------------------------------------------- Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more researchers is by leaving us a review on Apple Podcasts. We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Elyn Rowe, reviewed by Courtney Kloske and edited by Michelle Grover. The bibliography was created by Jacques Ferreira and the wordcloud was generated by Sarah Louadi (www.wordart.com). Big thanks to the sorting team for sorting all the papers published in March into themes for our episodes, and to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"  

Welcome to EyePod Bayer!   In this episode we talk about Sars-Cov-2 effects on the vessels.   Enjoy! eyepod@bayer.com MA-M_AFL-DK-0067-1      

Elyn is back to guide your through all of the connections between blood vessels and Alzheimer disease, from papers published in February 2021. Starting the episode off with how midlife vascular risk factors can influence AD risk, and finishing with treatments for AD that target the vasculature, you're sure to leave this episode appreciating how intertwined heart health and brain health are. Well worth the longer listen for all of the new insight!   Sections in this episode:  Midlife Vascular Risk Factors for AD (3.16)  Associations of Cerebrovascular Pathology with AD Pathology and Clinical Progression (11.09)  Streamlining Quantification of Vascular Pathology (21.16)                                            Mechanisms of AD in the Vasculature (25.54)    AD Treatments Targeting the Vasculature (30.14) --------------------------------------------------------------You can find the bibliography for this episode by clicking here. To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharingYou can also join our mailing list to receive a newsletter once per month by filling this form. Or tweet at us: @AMiNDR_podcast  --------------------------------------------------------------We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback form here:    https://forms.gle/5aq2JyrT6g4P1m8v6 You can also share your thoughts and suggestions by contacting us:  Email: amindrpodcast@gmail.com  Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastYoutube: AMiNDR Podcast--------------------------------------------------------------We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Elyn Rowe, reviewed by Courtney Kloske, and edited by Anusha Kamesh. The bibliography was created by Satish Kumar and the wordcloud was generated by Sarah Louadi (www.wordart.com). Big thanks to sorting manager Elyn Rowe and the rest of the sorting team for sorting all the papers published in January into themes for our episodes, and to our managers Sarah Louadi, Ellen Koch and Anusha Kamesh, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, creating bibliographies, and promotions. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  --------------------------------------------------------------*About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"  

Annual Review of Cell and Developmental Biology Vol. 34:111-136 Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583 Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Dr. Mark Allen, Co-Founder and CEO, Elevian is looking to disrupt the longevity business by developing a recombinant GDF11 to treat and prevent multiple age-related diseases. The first application being investigated is for stroke recovery drawing on the discovery that GDF11 decreases with age and when replenished, returns the brain to a healthier pattern of vascularization. Not looking to extend just the life span, the goal is to target the aging process and extend the healthy lifespan. @ElevianInc #aging #StrokeRecovery #AgeRelatedDisease #GDF11 Elevian.com Download the transcript here.

Dr. Mark Allen, Co-Founder and CEO, Elevian is looking to disrupt the longevity business by developing a recombinant GDF11 to treat and prevent multiple age-related diseases. The first application being investigated is for stroke recovery drawing on the discovery that GDF11 decreases with age and when replenished, returns the brain to a healthier pattern of vascularization. Not looking to extend just the life span, the goal is to target the aging process and extend the healthy lifespan. @ElevianInc #aging #StrokeRecovery #AgeRelatedDisease #GDF11 Elevian.com Listen to the podcast here.

Elyn is back with more on vascular contributions to Alzheimer disease. Tune in to hear about clinical studies connecting the vasculature to the AD pathology, mechanistic studies about amyloid clearance and deposition into cerebral vessels, and much more - all from papers published in January 2021! Sections in this episode: Clinical Studies - Connecting the Vasculature to the AD Pathology (3.20) Cerebral Amyloid Angopathy (14.36) Cerebral Blood Flow (27.23) Endothelial/Blood-Brain Barrier Damage (30.37)  ------------------------------------------------------------------  Click here to see the list of papers covered in this episode.To access the folder with the bibliographies for the month of January, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:https://drive.google.com/drive/folders/1tKnPbfs5Uedi86weYxorCNpQqC7BfD7P?usp=sharingYou can also join our mailing list to receive a newsletter once per month by filling this form. Or tweet at us: @AMiNDR_podcast  ------------------------------------------------------------------ We would appreciate your feedback so we can better cater to your needs.  You can fill our feedback form here:    ---------->  https://forms.gle/5aq2JyrT6g4P1m8v6  You can also share your thoughts and suggestions by contacting us:  Email: amindrpodcast@gmail.com  Facebook:  AMiNDR  Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcast------------------------------------------------------------------ Every episode of AMiNDR is the result of a huge team effort. Today's episode was scripted and hosted by Elyn Rowe, and edited by Anusha Kamesh. Big thanks to Elyn Rowe, Jacques Ferreira and the rest of the sorting team for sorting all the papers published in January into themes for our episodes, to our managers Sarah Louadi and Ellen Koch for keeping everything running smoothly, and props to the whole team that works very hard behind the scenes to make all this possible. Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   ------------------------------------------------------------------ If you are interested in joining the team, send us your CV by email. We are specifically looking for help with abstract summary and podcast editing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  ------------------------------------------------------------------ *About AMiNDR: *  Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"   

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.10.334664v1?rss=1 Authors: Ghobrial, M., Charish, J., Takada, S., Valiante, T., Monnier, P., Radovanovic, I., Bader, G., Waelchli, T. Abstract: A large number of hospitalized COVID-19 patients show neurological symptoms such as ischemic- and hemorrhagic stroke as well as encephalitis, and SARS-CoV-2 can directly infect endothelial cells leading to endotheliitis across multiple vascular beds. These findings suggest an involvement of the brain- and peripheral vasculature in COVID-19, but the underlying molecular mechanisms remain obscure. To understand the potential mechanisms underlying SARS-CoV-2 tropism for brain vasculature, we constructed a molecular atlas of the expression patterns of SARS-CoV-2 viral entry-associated genes (receptors and proteases) and SARS-CoV-2 interaction partners in human (and mouse) adult and fetal brain as well as in multiple non-CNS tissues in single-cell RNA-sequencing data across various datasets. We observed a distinct expression pattern of the cathepsins B (CTSB) and -L (CTSL) - which are able to substitute for the ACE2 co-receptor TMPRSS2 - in the human vasculature with CTSB being mainly expressed in the brain vasculature and CTSL predominantly in the peripheral vasculature, and these observations were confirmed at the protein level in the Human Protein Atlas and using immunofluorescence stainings. This expression pattern of SARS-CoV-2 viralentry associated proteases and SARS-CoV-2 interaction partners was also present in endothelial cells and microglia in the fetal brain, suggesting a developmentally establishedSARS-CoV-2 entry machinery in the human vasculature. At both the adult and fetal stages, we detected a distinct pattern of SARS-CoV-2 entry associated genes' transcripts in brain vascular endothelial cells and microglia, providing a potential explanation for an inflammatory response in the brain endothelium upon SARS-CoV-2 infection. Moreover, CTSB was co-expressed in adult and fetal brain endothelial cells with genes and pathways involved in innate immunity and inflammation, angiogenesis, blood-brain-barrier permeability, vascular metabolism, and coagulation, providing a potential explanation for the role of brain endothelial cells in clinically observed (neuro)vascular symptoms in COVID-19 patients. Our study serves as a publicly available single-cell atlas of SARS-CoV-2 related entry factors and interaction partners in human and mouse brain endothelial- and perivascular cells, which can be employed for future studies in clinical samples of COVID-19 patients. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.05.326512v1?rss=1 Authors: Baez-Yanez, M. G., Siero, J. C. W., Petridou, N. Abstract: BOLD fMRI is a commonly used technique to map brain activity; nevertheless, BOLD fMRI is an indirect measurement of brain function triggered by neurometabolic and neurovascular coupling. Hence, the origin of the BOLD fMRI signal is quite complex, and the signal formation depends, among others, on the geometry of the cortical vasculature and the associated hemodynamic behavior. To characterize and quantify the hemodynamic contributions to the BOLD signal response in humans, it is necessary to adopt a computational model that resembles the human cortical vascular architecture and mimics realistic hemodynamic changes. To this end, we have developed a statistically defined 3D vascular model that resembles the human cortical vasculature. Using this model, we simulated hemodynamic changes triggered by a neuronal activation and local magnetic field disturbances created by the vascular topology and the blood oxygenation changes. The proposed model considers also the biophysical interactions and the intrinsic magnetic properties of the nearby tissue in order to compute a dynamic BOLD fMRI signal response. This computational pipeline results in an integrated biophysical model that can provide a better insight on the understanding and quantification of the hemodynamic fingerprint of the BOLD fMRI signal evolution. Copy rights belong to original authors. Visit the link for more info

Cholesterol Therapy-Mervyn Singer Troponin in Critical Care Patients and Outcomes-Anne marie Docherty Targeting the Vasculature in Sepsis: A Means or an End?-Simon Lambden The Right Heart in Critical Illness-Susanna Price Panel Conversation and Questions-Mervyn Singer, Annemarie Docherty, Simon Lambden & Susanna Price

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.09.243394v1?rss=1 Authors: Tahir, W., Kura, S., Zhu, J., Cheng, X., Damseh, R., Tadesse, F., Seibel, A., Lee, B. S., Lesage, F., Sakadzic, S., Boas, D. A., Tian, L. Abstract: Segmentation of blood vessels from two-photon microscopy (2PM) angiograms of brains has important applications in hemodynamic analysis and disease diagnosis. Here we develop a generalizable deep-learning technique for accurate 2PM vascular segmentation of sizable regions in mouse brains acquired from multiple 2PM setups. In addition, the technique is computationally efficient, making it ideal for large-scale neurovascular analysis. Introduction: Vascular segmentation from 2PM angiograms is usually an important first step in hemodynamic modeling of brain vasculature. Existing state-of-the-art segmentation methods based on deep learning either lack the ability to generalize to data from various imaging systems, or are computationally infeasible for large-scale angiograms. In this work, we present a method which improves upon both these limitations by being generalizable to various imaging systems, and also being able to segment very large-scale angiograms. Methods: We employ a computationally efficient deep learning framework based on a semi-supervised learning strategy, whose effectiveness we demonstrate on experimentally acquired in-vivo angiograms from mouse brains of dimensions up to 808x808x702 micrometers. Results: After training on data from only one 2PM microscope, we perform vascular segmentation on data from another microscope without any network tuning. Our method demonstrates 10x faster computation in terms of voxels-segmented-persecond and 3x larger depth compared to the state-of-the-art. Conclusion: Our work provides a generalizable and computationally efficient anatomical modeling framework for the brain vasculature, which consists of deeplearning based vascular segmentation followed by graphing. It paves the way for future modeling and analysis of hemodynamic response at much greater scales that were inaccessible before. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.26.174227v1?rss=1 Authors: Sullender, C. T., Richards, L. M., He, F., Luan, L., Dunn, A. K. Abstract: Anesthetized animal models are used extensively during neurophysiological and behavioral studies despite systemic effects from anesthesia that undermine both accurate interpretation and translation to awake human physiology. In this paper, we characterize the impact of isoflurane on cerebral blood flow (CBF) during the induction of general anesthesia in awake mice using multi-exposure speckle imaging (MESI). We highlight the large anatomical changes caused by the vasodilatory inhalant with wide-field imagery and quantify the cortical hemodynamics with MESI across multiple subjects and imaging sessions. Compared to the awake state, we measured, on average, an 18% increase in surface vessel diameter accompanied by a 135% increase in vascular flux and 92% increase in parenchyma perfusion. These large alterations to the cortical vasculature and CBF are unrepresentative of normal physiology and provide further evidence that neuroscience experiments would benefit from transitioning to un-anesthetized awake animal models. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.25.110908v1?rss=1 Authors: Mondo, E., Becker, S. C., Kautzman, A. G., Schifferer, M., Baer, C. E., Chen, J., Huang, E. J., Simons, M., Schafer, D. P. Abstract: Microglia, the resident macrophages of the central nervous system (CNS), are dynamic cells, constantly extending and retracting their processes as they contact and functionally regulate neurons and other glial cells. There is far less known about microglia-vascular interactions, particularly under healthy steady-state conditions. Here, we use the male and female mouse cerebral cortex to show that a higher percentage of microglia associate with the vasculature during the first week of postnatal development compared to older ages and the timing of these associations are dependent on the fractalkine receptor (CX3CR1). Similar developmental microglia-vascular associations were detected in the prenatal human brain. Using live imaging in mice, we found that juxtavascular microglia migrated when microglia are actively colonizing the cortex and became stationary by adulthood to occupy the same vascular space for nearly 2 months. Further, juxtavascular microglia at all ages contact vascular areas void of astrocyte endfeet and the developmental shift in microglial migratory behavior along vessels corresponded to when astrocyte endfeet more fully ensheath vessels. Together, our data provide a comprehensive assessment of microglia-vascular interactions. They support a mechanism by which microglia use the vasculature to migrate within the developing brain parenchyma. This migration becomes restricted upon the arrival of astrocyte endfeet when juxtavascular microglia then establish a long-term, stable contact with the vasculature. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.16.099705v1?rss=1 Authors: Henriksen, B. L. E., Jensen, K. H. R., Berg, R. W. Abstract: Visualization of the vasculature in three dimensions (3D) has become attractive, particularly in stroke models. 3D-reconstruction is aided by tissue-clearing, where the transparency allows imaging of fluorescent probes in deeper structures. The vasculature is commonly stained by fluorescent lipophilic dyes that are incorporated into the wall during transcardial perfusion. Nevertheless, tissue clearing involves extracting the light-scattering lipids, and hence also the lipid-appended dyes. The wash-out likely depends on dye and its aldehyde-fixability. Fixation secures cross-linking to proteins and hence retainment in the tissue. However, the compatibility of various types of dyes is largely unknown. We tested and compared 9 different dyes for vasculature staining and tolerance to lipid clearing, which was quantified using deep learning image segmentation. Among the dyes, we found a subset that is both cost-effective and compatible with tissue lipid clearing. We suggest these dyes will provide a valuable tool for future investigations. Copy rights belong to original authors. Visit the link for more info

Years ago, my own gut problems motivated me to seek answers outside the existing medical establishment, and with the help of my wife Julie I was able to get my diet and health back on track. Having now worked with thousands of athletes on their own health challenges and performance goals, it’s clear there are specific pitfalls that can accompany a high-level training regimen. On this podcast, NBT Scientific Director and coach Megan Hall is with me to discuss the latest science and clinical practice on the athlete’s gut. She talks about the importance of having a healthy GI system, why athletes struggle in this area, and specifically what to do when problems arise. We also discuss what I did to regain my own gut health. Be sure to see the end of the show notes for the outline Megan wrote to prepare for this podcast. It’s an excellent resource for anyone seeking solutions for their own gut problems. Here’s the outline of this interview with Megan Hall: [00:00:54] Podcast: Microbiome Myths and Misconceptions, with Lucy Mailing. [00:01:40] The importance of gut health. [00:03:13] Podcasts focusing on gut health, with Michael Ruscio, Jason Hawrelak, and Lauren Petersen. [00:03:51] Study: Lupien-Meilleur, Joseph, et al. "The interplay between the gut microbiota and gastrointestinal peptides: potential outcomes on the regulation of glucose control." Canadian Journal of Diabetes (2019). [00:04:12] Gut-muscle axis; Studies: Ticinesi, Andrea, et al. "Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: is there a gut–muscle axis?." Nutrients 9.12 (2017): 1303; and Lustgarten, Michael Sandy. "The role of the gut microbiome on skeletal muscle mass and physical function: 2019 update." Frontiers in Physiology 10 (2019): 1435.  [00:05:43] Why athletes struggle with gut health; Studies: Costa, R. J. S., et al. "Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease." Alimentary pharmacology & therapeutics 46.3 (2017): 246-265; and Clark, Allison, and Núria Mach. "Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes." Journal of the International Society of Sports Nutrition 13.1 (2016): 43. [00:06:59] Article: de Oliveira, Erick P. "Runner's diarrhea: what is it, what causes it, and how can it be prevented?." Current opinion in gastroenterology 33.1 (2017): 41-46. [00:07:27] The 3 main causes of exercise-induced diarrhea: GI ischemia and reperfusion, mechanical and nutritional. [00:13:25] UCAN SuperStarch. [00:15:03] FODMAP fibers can increase gut symptoms; Study: Lis, Dana M., et al. "Low FODMAP: a preliminary strategy to reduce gastrointestinal distress in athletes." Medicine & Science in Sports & Exercise 50.1 (2018): 116-123. [00:17:30] Exercise-induced endotoxemia and ischemic injuries; Lipopolysaccharide (LPS) [00:18:08] Podcast: A Statin Nation: Damaging Millions in a Brave New Post-health World, with Malcolm Kendrick. [00:19:05] Nutrition and immune system in athletes; Studies: 1, 2, 3, 4. [00:20:03] Common gut symptoms we see. [00:21:37] Nutrient deficiencies and overloads: zinc, magnesium, iron. [00:22:27] Iron overload impedes cardiovascular benefits of exercise; Study: Rossi, Emilly Martinelli, et al. "Chronic Iron Overload Restrains the Benefits of Aerobic Exercise to the Vasculature." Biological Trace Element Research (2020): 1-14. [00:25:08] Hepcidin; exercise increases hepcidin, which can lead to iron deficiency; Study: Goto, Kazushige, et al. "Resistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise." Plos one 15.2 (2020): e0228766. [00:27:55] What to do about GI symptoms. [00:28:07] Dr. Josh Turknett’s 4-Quadrant Model, described in this podcast: How to Win at Angry Birds: The Ancestral Paradigm for a Therapeutic Revolution. [00:28:19] Dietary manipulations; Autoimmune Protocol (AIP). [00:29:30] How Chris fixed his gut. [00:30:07] Book: The Paleo Diet for Athletes by Loren Cordain, PhD. [00:32:41] Lundburg rice tests for arsenic. [00:32:59] Training fuel: Carb + protein + fat vs. simple carbs alone. [00:37:18] Ultramarathon runners still in ketosis with up to 600g carbohydrate per day; Study: Edwards, Kate H., Bradley T. Elliott, and Cecilia M. Kitic. "Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners." Journal of Sports Sciences 38.4 (2020): 366-374. [00:38:00] Team Sky’s James P Morton on promoting endurance training adaptation in skeletal muscle by nutritional manipulation; Study: Hawley, John A., and James P. Morton. "Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation." Clinical and Experimental Pharmacology and Physiology 41.8 (2014): 608-613. Also see article: The IRONMAN Guide to Ketosis, by Megan Hall and Tommy Wood. [00:38:24] “Sleep-low” strategy; Study: Marquet, Laurie-Anne, et al. "Enhanced endurance performance by periodization of carbohydrate intake:“sleep low” strategy." Medicine & Science in Sports & Exercise 48.4 (2016): 663-672. [00:40:23] Probiotics; Study: Wosinska, Laura, et al. "The Potential Impact of Probiotics on the Gut Microbiome of Athletes." Nutrients 11.10 (2019): 2270; Serum-derived Bovine Immunoglobulin in SBI Protect. [00:40:57] Testing if all else fails: blood, stool, Organic Acids Test (OAT). [00:43:05] Basic blood chemistry tests for gut health. [00:47:32] Gut microbiome testing; Onegevity Gutbio test. [00:48:44] Treatment for gut pathology. [00:49:08] Jason Hawrelak’s Probiotic Advisor. [00:49:48] Podcast: How to Manage Stress, with Simon Marshall, PhD. [00:50:52] Dietary fat causing intestinal permeability. [00:52:04] Blog post: Is a high-fat or ketogenic diet bad for your gut? by Lucy Mailing. [00:54:44] Getting enough calories. [00:55:00] Relative Energy Deficiency in Sport (RED-S); Podcast: How to Identify and Treat Relative Energy Deficiency in Sport (RED-S), with Nicky Keay. [00:55:10] Studies on the detrimental effects of energy deficiency in athletes: 1. Torstveit, Monica Klungland, et al. "Within-day energy deficiency and metabolic perturbation in male endurance athletes." International journal of sport nutrition and exercise metabolism 28.4 (2018): 419-427 and 2. Fahrenholtz, Ida Lysdahl, et al. "Within‐day energy deficiency and reproductive function in female endurance athletes." Scandinavian journal of medicine & science in sports 28.3 (2018): 1139-1146. [00:56:35] Study: Hough, John, et al. "Daily running exercise may induce incomplete energy intake compensation: a 7-day crossover trial." Applied Physiology, Nutrition, and Metabolism 45.4 (2020): 446-449. [01:00:18] Fiber - timing and type. [01:02:27] Orthorexia. [01:05:02] Only 12% of Americans are metabolically healthy; Study: Araújo, Joana, Jianwen Cai, and June Stevens. "Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016." Metabolic syndrome and related disorders 17.1 (2019): 46-52. [01:06:40]  Become an NBT Patron and gain access to the Elite Performance Members Club Forum. [01:07:05] Megan's outline for this podcast.

Tim Padera, PhD, and research fellow, Ethel Pereira, PhD, provide insight into their study of transit tumor cells.

In this episode, Ethel Pereira and Tim Padera share why the protocol in this study isn’t safe to use for humans yet, and what the next steps will advance the research to improve patient care.

Dr Facciabene (University of Pennsylvania, Philadelphia, USA) talks to ecancertv at ITOC3 about novel TEM-1 vaccines. The vaccine targets Tumour Endothelial Marker 1, eliminating tumour vasculature and inducing a secondary immune response. The trials have proven effective in models of breast cancer, Lewis lung carcinoma, cervical cancer and colorectal cancer. Host angiogenesis in wound healing and pregnancy is unaffected by the vaccine.

Johannes Hell and Manuel Navedo explain that modification of a particular serine residue affects the activity of the L-type calcium channel Cav1.2 in the brain and vasculature, but not in the heart.

In the emerging field of 3D bioprinting, there are those who work with synthetic materials, and others who use materials that come from nature. Bioengineer Monica Moya of the Lawrence Livermore National Laboratory has used a 3D printer and a ‘bio-ink’ made of materials compatible with the human body to create living blood vessels. "So one of our inks is made out of the same stuff that you find in a blood clot. And we intentionally do this because we are in a sense, are co-engineering with the cells. So, we’re using materials that the cells recognize and understand what they’re supposed to do. So that kind of takes the pressure off of us because then the cells are going to do the things that they already know how to do without us having to tell them, because you know, they are the original engineers of life. They already know how to build blood vessels – and so what we do is we kind of orchestrate that whole process." Their bioprinted vasculature system could be used for toxicology studies, medical treatment testing and provide a test bed for the ultimate goal in the field - printing implantable organs.

Five articles from the October 2015 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles for this month are  “Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans,” “Why Do Osteochondral Allografts Survive?: Comparative Analysis of Cartilage Biochemical Properties Unveils a Molecular Basis for Durability,” “Autograft Versus Allograft Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized Clinical Study With a Minimum 10-Year Follow-up,” “Deficits in Glenohumeral Passive Range of Motion Increase Risk of Shoulder Injury in Professional Baseball Pitchers: A Prospective Study,” and “Knee Kinematics During Noncontact Anterior Cruciate Ligament Injury as Determined From Bone Bruise Location.”     Click here to read the articles. 

Enrico Giraudo Laboratory of Transgenic Mouse Models, Institute for Cancer Research (IRCC), and Department of Science and Drug Technology, University of Torino, Candiolo, ITALY speaks on "Semaphorin 3A: a new tool to normalize the tumor vasculature and to block metastasis dissemination". This seminar has been recorded by ICGEB Trieste

A transcription factor protects the heart from radiation-induced damage.

The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived embryoid bodies (EBs). We found that incubation with retinoic acid (RA) and, more potently, with RA in combination with cAMP, induced the expression of the lymphatic competence marker LYVE-1 in the vascular structures of the EBs. This effect was dependent on RA receptor (RAR)-alpha and protein kinase A signaling. RA-cAMP incubation also promoted the development of CD31+/LYVE-1+/Prox1+ cell clusters. In situ studies revealed that RAR-alpha is expressed by endothelial cells of the cardinal vein in ED 9.5-11.5 mouse embryos. Timed exposure of mouse and Xenopus embryos to excess of RA upregulated LYVE-1 and VEGFR-3 on embryonic veins and increased formation of Prox1-positive lymphatic progenitors. These findings indicate that RA signaling mediates the earliest steps of lymphatic vasculature development. Copyright (C) 2010 S. Karger AG, Basel

Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy.

09/29/2008 | CTA of Mesenteric Vasculature: A Guide to Abdominal Pathology: Part 2

09/22/2008 | CTA of Mesenteric Vasculature: A Guide to Abdominal Pathology: Part 1

02/12/2007 | CTA of the Mesenteric Vasculature: A Guide to Abdominal Pathology

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.15.043588v1?rss=1 Authors: Jansson, D., Dieriks, V., Rustenhoven, J., Smyth, L., Scotter, E., Aalderink, M., Feng, S., Johnson, R., Schweder, P., Mee, E., Heppner, P., Turner, C., Curtis, M., Faull, R., Dragunow, M. Abstract: Neuroinflammation is a key component of virtually all neurodegenerative diseases; preceding neuronal loss and associating directly with cognitive impairment. Neuroinflammatory signals can originate and be amplified at barrier tissues such as brain vasculature, surrounding meninges and the choroid plexus. We designed a high-throughput screening system to target inflammation in cells of the blood-brain barrier (primary human pericytes and endothelia) and microglia enabling us to target human disease-specific inflammatory modifiers. Screening an FDA-approved drug library we identified digoxin and lanatoside C, members of the cardiac glycoside family as inflammatory modulating drugs that work in blood-brain barrier cells. A novel ex vivo assay of leptomeningeal and choroid plexus explants further confirmed that these drugs maintain their function in 3D cultures of brain border tissues. While current therapeutic strategies for the treatment of neurodegenerative diseases are missing the mark in terms of targets, efficacy and translatability, our innovative approach using in vitro and ex vivo human barrier cells and tissues to target neuroinflammatory pathways is a step forward in drug development and testing, and brings us closer to translatable treatments for human neurodegenerative disease. Copy rights belong to original authors. Visit the link for more info