Podcasts about toxoplasma gondii

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Best podcasts about toxoplasma gondii

Latest podcast episodes about toxoplasma gondii

Through Conversations
The Hidden Forces Shaping Your Relationships – Bill von Hippel

Through Conversations

Play Episode Listen Later Apr 28, 2025 66:09


Grab your copy of The Time is Now and start your journey toward living a more intentional and fulfilling life -⁠⁠ https://a.co/d/aDYCQ9oDownload the episode's full transcript for free - https://throughconversations.kit.com/8e95ce8c66In this conversation, Alex and Bill von Hippel explore the themes of evolutionary psychology, the tension between autonomy and cooperation, and the effects of modern society and technology on human connection and happiness. They discuss how social media and dating apps influence relationships and the paradox of wealth versus happiness in contemporary life.William von Hippel is a psychologist, professor, and author.The Social Paradox - https://a.co/d/3idGhNTChapters00:00 Introduction to The Social Paradox03:01 The Impact of Toxoplasma Gondii on Behavior05:59 Free Will and Evolutionary Psychology09:13 The Tension Between Autonomy and Cooperation12:01 The Modern Shift Towards Autonomy14:59 The Role of Social Media in Connection18:09 Happiness in Modern Society vs. Hunter-Gatherer Life21:04 The Paradox of Wealth and Happiness23:56 The Effects of Dating Apps on Relationships32:39 The Dynamics of Relationships in Urban vs Rural Settings33:35 Balancing Autonomy and Connection in Relationships35:14 Understanding Loyalty and Infidelity in Relationships38:22 The Mystery of Falling in Love41:22 Politics, Evolution, and Empathy44:40 The Role of Religion in Political Preferences48:13 The Decline of Religion and Its Impact on Connection50:34 The Connection Between Religion and Happiness52:23 The Importance of Loose Connections55:25 Rebalancing Autonomy and Connection in Modern LifeJoin this channel to get access to exclusive perks:https://www.youtube.com/channel/UCl67XqJVdVtBqiCWahS776g/join// Connect With Me //ORDER MY BOOK, THE TIME IS NOW: A GUIDE TO HONOR YOUR TIME ON EARTH: ⁠⁠⁠⁠https://www.timeisnowbook.comWebsite: ⁠⁠⁠https://throughconversations.com⁠⁠Substack - https://throughconversations.substack.comYouTube community -https://www.youtube.com/channel/UCl67XqJVdVtBqiCWahS776g/join// Social //X: ⁠⁠⁠https://x.com/ThruConvPodcast⁠⁠Instagram: ⁠⁠⁠https://www.instagram.com/thruconvpodcast/?hl=en⁠⁠⁠YouTube: ⁠⁠https:⁠//www.youtube.com/channel/UCl67XqJVdVtBqiCWahS776g

Head Shepherd
All you need to know about Toxoplasmosis with Connor Bury

Head Shepherd

Play Episode Listen Later Mar 16, 2025 34:41


This week on the Head Shepherd podcast, we're deep-diving into Toxoplasma Gondii with veterinary parasitologist Connor Bury. Connor walks us through the lifecycle of the parasite, how it's impacting sheep farmers across the world, and what we can do to reduce the impacts of it.Whilst many know cats are the main culprits in spreading Toxo, did you know the importance of water quality when it comes to reducing the spread of the parasite? Tune in today to learn more and equip yourself with the knowledge to lower your sheep's risk of toxoplasmosis.Head Shepherd is brought to you by neXtgen Agri International Limited. We help livestock farmers get the most out of the genetics they farm with. Get in touch with us if you would like to hear more about how we can help you do what you do best: info@nextgenagri.com.Thanks to our sponsors at MSD Animal Health and Allflex, and Heiniger Australia and New Zealand. Please consider them when making product choices, as they are instrumental in enabling us to bring you this podcast each week.Check out Heiniger's product range HERECheck out the MSD range HERECheck out Allflex products HERE

Ask Doctor Dawn
From H5N1 Updates to Zombie Parasites: Exploring Viral Mutations, Medical Challenges, and Nature's Mind Control

Ask Doctor Dawn

Play Episode Listen Later Jan 18, 2025 50:46


Broadcast from KSQD, Santa Cruz on 1-16-2025: Dr. Dawn provides a comprehensive analysis of the H5N1 bird flu situation, explaining viral mutations, transmission patterns, and potential risks in both agricultural and human populations. She examines the concerning implications of research showing rapid viral mutations after human transmission and discusses available antiviral treatments. The show addresses concerns about mirror cell research, warning about potential dangers of creating mirror-image microbes that could be unrecognizable to immune systems. She discusses the alarming rise in hypothermia deaths across America, noting how sudden temperature fluctuations and increasing homelessness contribute to doubled mortality rates since 1999. Dr. Dawn provides detailed analysis of an email from a person post-gastric bypass with dangerous blood sugar spikes, outlining potential causes and suggesting comprehensive testing approaches. A caller presents case of dual ureter injury during C-section surgery, Dr. Dawn explores treatment options and complications. She then responds to another caller with recurring toenail fungus, discussing various approaches from traditional medications to alternative remedies. She shares fascinating insights from the book "How to Win Friends and Influence Fungi," exploring parasites that control host behavior, from shrimp-manipulating worms to fungi that turn insects into spore-dispersing zombies.

Transformation Talk Radio
Addiction in the Family System

Transformation Talk Radio

Play Episode Listen Later Jan 13, 2025 57:41


In this episode Jacqueline and Chris discuss addiction and its impact on the family from an experiential perspective. Jacqueline from her clinical perspective, having worked at a treatment centre and in the field of addiction for many years. Chris from his perspective of being an adult child of an alcoholic, a recovered addict himself and now a sponsor and coach to people suffering from the disease. Their conversation helps demystify addiction and guides the listener on how to better handle addiction when it shows up in their own family system. 

Cause of Death -
S8 E4: Here Kitty Kitty: The Story of Toxoplasma gondii

Cause of Death -

Play Episode Listen Later Apr 21, 2024 29:57


You can reach me on the website at http://www.causeofdeath100secs.net or you can email me at mailto:Jackie@causeofdeath100secs.net. My Link Tree can be found at: https://linktr.ee/CauseofDeathpod When I was in college, I had a Microbiology professor who swore that cats were out to kill us all. She told everyone in any class that she taught that cats carried every disease known to man and they were going to pass them all to us. Cats were single-handedly going to end humankind. Now, she knew this wasn't true and if you've listened to any of my past episodes, you know it's not true, but today, I'm going to talk about a parasite that cats carry that could have a significant impact on cat owners. Toxoplasma gondii Show Notes: https://www.cdc.gov/dpdx/toxoplasmosis/index.html https://www.cdc.gov/parasites/toxoplasmosis/health_professionals/index.html#tx https://www.cdc.gov/parasites/toxoplasmosis/gen_info/faqs.html https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/toxoplasmosis-cats https://www.ncbi.nlm.nih.gov/books/NBK563286/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162817/ https://emedicine.medscape.com/article/1743814-overview?form=fpf https://journals.asm.org/doi/10.1128/cmr.00115-19 https://www.merckmanuals.com/professional/infectious-diseases/extraintestinal-protozoa/toxoplasmosis https://www.cell.com/trends/parasitology/abstract/0169-4758(88)90018-X https://www.ncbi.nlm.nih.gov/books/NBK7752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109627/ https://www.sciencedirect.com/topics/medicine-and-dentistry/toxoplasma-gondii https://emedicine.medscape.com/article/229969-overview?form=fpf https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-04528-x https://www.nature.com/articles/s41467-021-24092-x https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-04445-z https://www.childrenshospital.org/conditions/congenital-toxoplasmosis https://www.nature.com/articles/s41537-022-00292-2 https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1550-7408.2008.00345.x https://pubmed.ncbi.nlm.nih.gov/19744303/ https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1863-2378.2009.01276.x https://emedicine.medscape.com/article/229969-overview?scode=msp&st=fpf&anfErrHint=true&icd=login_error_gg_mismatch_fpf&client=205502&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI5OTY5LW92ZXJ2aWV3P2Zvcm09ZnBmJnNjb2RlPW1zcCZzdD1mcGYmc29jaWFsU2l0ZT1nb29nbGU&su=EXUHB2/fkQ9sBjQl7hkqDIHTs0Xd4JxI8gikIGYJMIgmCZ+wTe/gcdb9CztGtN/y&form=login https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1863-2378.2009.01276.x https://www.scielo.br/j/mioc/a/c3zTqcQyh8DMhN3NpCddHGs/ https://www.researchgate.net/publication/24416205_Toxoplasma_gondii_1908-2008_homage_to_Nicolle_Manceaux_and_Splendore https://www.semanticscholar.org/paper/Toxoplasma-gondii%3A-1908-2008%2C-homage-to-Nicolle%2C-Ferguson/fe26b8691f59bebf521dd5530b978b23240e68d5 https://www.sciencedirect.com/science/article/abs/pii/S0020751909001064 https://www.academia.edu/61852031/Toxoplasma_gondii_1908_2008_homage_to_Nicolle_Manceaux_and_Splendore https://emedicine.medscape.com/article/229969-overview?form=fpf https://link.springer.com/chapter/10.1007/978-1-4612-2476-1_27 https://pubmed.ncbi.nlm.nih.gov/19430635/ https://pubmed.ncbi.nlm.nih.gov/3535705/ https://link.springer.com/chapter/10.1007/978-1-4612-2476-1_27 https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-6-334 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000964 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000964#bib76 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000964#bib102 https://www.sciencedirect.com/science/article/abs/pii/S0020751909001064 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000940 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000605 https://www.sciencedirect.com/science/article/abs/pii/S0020751909000629 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1550-7408.2008.00345.x#:~:text=This%20protozoan%20parasite%20was%20first,storms%20in%20sheep%20in%201957. https://pubmed.ncbi.nlm.nih.gov/19120791/ https://pubmed.ncbi.nlm.nih.gov/19744303/ https://www.sciencedirect.com/science/article/abs/pii/B9780123964816000015 https://www.researchgate.net/publication/26802592_A_Brief_History_and_Overview_of_Toxoplasma_gondii https://primo.qatar-weill.cornell.edu/discovery/fulldisplay?docid=cdi_proquest_miscellaneous_733569200&context=PC&vid=974WCMCIQ_INST:VU1&lang=en&adaptor=Primo%20Central&tab=Everything&query=sub,exact,%20Oocysts%20-%20parasitology%20,AND&mode=advanced https://scholar.google.com/scholar?hl=en&inst=14319616763037279173&q=History+of+the+discovery+of+the+life+cycle+of+Toxoplasma+gondii. https://www.sciencedirect.com/science/article/abs/pii/S0020751909000605 https://link.springer.com/article/10.1186/s13071-021-04769-4

PVRoundup Podcast
Cat-borne parasite contributes to frailty in older adults

PVRoundup Podcast

Play Episode Listen Later Nov 21, 2023 3:27


Which common infection is associated with frailty in older adults? Find out about this and more in today's PV Roundup podcast.

Futureproof with Jonathan McCrea
Futureproof Extra: Toxoplasma Gondii

Futureproof with Jonathan McCrea

Play Episode Listen Later Sep 26, 2023 16:04


What if we told you that a tiny parasite might be influencing the very core of wolf behaviour, making these fierce predators act in ways contrary to their survival instincts? Enter Toxoplasma Gondii, the unseen puppeteer. Kira Cassidy, a leading research biologist from the Yellowstone Wolf Project - who has delved deep into the mysteries of this parasite and its staggering effects not just on wolves, but possibly on us humans as well - joins Jonathan to discuss.

Marine Mammal Science
Toxoplasma gondii

Marine Mammal Science

Play Episode Listen Later Sep 23, 2023 28:13


On this week's episode Dr Scarlett Smash chats with Dr Sophie Zhu about the detection and genetic characterization of Toxoplasma gondii in feces from feral cats in central coastal California, that can be harmful to marine species.

PaperPlayer biorxiv cell biology
F-actin and Myosin F control apicoplast elongation dynamics which drive apicoplast-centrosome association in Toxoplasma gondii

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jun 28, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.27.546809v1?rss=1 Authors: Devarakonda, P. M., Sarmiento, V., Heaslip, A. T. Abstract: Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death. The apicoplast is a single copy organelle and therefore must be divided so that each daughter parasite inherits an apicoplast during cell division. In this study we identify new roles for F-actin and an unconventional myosin motor, TgMyoF, in this process. First, loss of TgMyoF and actin lead to an accumulation of apicoplast vesicles in the cytosol indicating a role for this actomyosin system in apicoplast protein trafficking or morphological integrity of the organelle. Second, live cell imaging reveals that during division the apicoplast is highly dynamic, exhibiting branched, U-shaped and linear morphologies that are dependent on TgMyoF and actin. In parasites where movement was inhibited by the depletion of TgMyoF, the apicoplast fails to associate with the parasite centrosomes. Thus, this study provides crucial new insight into mechanisms controlling apicoplast-centrosome association, a vital step in the apicoplast division cycle, which ensures that each daughter inherits a single apicoplast. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Faszination Fatigue
Dr. Auf der Straße über ME CFS und Toxoplasmose: Symptome, Diagnose und Behandlung # 86

Faszination Fatigue

Play Episode Listen Later Jun 26, 2023 103:16


Internal Medicine For Vet Techs Podcast

Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, VTS SAIM as we talk about: Bacteria friends! This particular bacteria can infect pretty much any warm blooded animal and is found everywhere! Let's learn about it!     Resources We Mentioned in the Show  VIN: Toxoplasmosis in Dogs and Cats:  https://www.vin.com/apputil/content/defaultadv1.aspx?meta=&pId=11196&id=3854170 Merck Veterinary Manual: Toxoplasmosis in Dogs:  https://www.merckvetmanual.com/dog-owners/disorders-affecting-multiple-body-systems-of-dogs/toxoplasmosis-in-dogs VCA: Toxoplasmosis:  https://vcahospitals.com/know-your-pet/toxoplasmosis    Thanks so much for tuning in. Join us again next week for another episode!  Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0  hour of RACE approved CE credit for each podcast episode you listen to.    Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on!   Join now! http://internalmedicineforvettechsmembership.com/   Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com  Get Access to the Technician Treasure Trove  Sign up at https://imfpp.org/treasuretrove    Thanks for listening!  – Yvonne and Jordan   

PaperPlayer biorxiv cell biology
Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness

PaperPlayer biorxiv cell biology

Play Episode Listen Later Feb 14, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.14.528480v1?rss=1 Authors: Vanagas, L., Munoz, D., Cristaldi, C., Ganuza, A., Najera, R., Bonardi, M. C., Turowski, V. R., Guzman, F., Deng, B., Kim, K., Sullivan, W. J., Angel, S. O. Abstract: Through regulation of DNA packaging, histone proteins are fundamental to a wide array of biological processes. A variety of post-translational modifications (PTMs), including acetylation, constitute a proposed histone code that is interpreted by reader proteins to modulate chromatin structure. Canonical histones can be replaced with variant versions that add an additional layer of regulatory complexity. The protozoan parasite Toxoplasma gondii is unique among eukaryotes in possessing a novel variant of H2B designated H2B.Z. The combination of PTMs and the use of histone variants is important for gene regulation in T. gondii, offering new targets for drug development. In this work, T. gondii parasites were generated in which the 5 N-terminal acetylatable lysines in H2B.Z were mutated to either alanine (c-Myc-A) or arginine (c-Myc-R). c-Myc-A mutant only displayed a mild effect in its ability to kill mice. c-Myc-R mutant presented an impaired ability to grow and an increase in differentiation to latent bradyzoites. This mutant line was also more sensitive to DNA damage, displayed no virulence in mice, and provided protective immunity against future infection. While nucleosome composition was unaltered, key genes were abnormally expressed during in vitro bradyzoite differentiation. Our results show that the N-terminal positive charge patch of H2B.Z is important for these procceses. Pull down assays with acetylated N-terminal H2B.Z peptide and unacetylated one retrieved common and differential interactors. Acetylated peptide pulled down proteins associated with chromosome maintenance/segregation and cell cycle, opening the question of a possible link between H2B.Z acetylation status and mitosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv cell biology
ATP synthase-associated CHCH domain proteins are critical for mitochondrial function in Toxoplasma gondii

PaperPlayer biorxiv cell biology

Play Episode Listen Later Feb 3, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.02.526833v1?rss=1 Authors: Usey, M. M., Huet, D. Abstract: Coiled-coil-helix-coiled-coil-helix (CHCH) domains consist of two pairs of cysteine residues that are oxidized to form disulfide bonds upon mitochondrial import. Proteins containing these domains play important roles in mitochondrial ultrastructure and in the biogenesis, function, and stability of electron transport chain complexes. Interestingly, recent investigations of the Toxoplasma gondii ATP synthase identified subunits containing CHCH domains. As CHCH domain proteins have never been found in any other ATP synthase, their role in T. gondii was unclear. Using conditional gene knockdown systems, we show that two T. gondii ATP synthase subunits containing CHCH domains are essential for the lytic cycle as well as stability and function of the ATP synthase. Further, we illustrated that knockdown disrupts multiple aspects of mitochondrial morphology. Mutation of key residues in the CHCH domains also caused mislocalization of the proteins. This work provides insight into the divergent aspects of the apicomplexan ATP synthase, which could uncover future drug targets. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

What The If?
TOXOPLASMA Gondii!

What The If?

Play Episode Listen Later Jan 13, 2023 48:21


Check out our membership rewards! Visit us at Patreon.com/Whattheif Got an IF of your own? Want to have us consider your idea for a show topic? Send YOUR IF to us! Email us at feedback@whattheif.com and let us know what's in your imagination. No idea is too small, or too big! Don't miss an episode! Subscribe at WhatTheIF.com Keep On IFFin', Philip, Matt & Gaby

PaperPlayer biorxiv cell biology
Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and exocytosis in Toxoplasma gondii

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jan 9, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.09.523261v1?rss=1 Authors: Arabiatorre, A., Formanowicz, M., Bankaitis, V. A., Grabon, A. Abstract: Phosphoinositide metabolism defines the foundation of a major signaling pathway that is conserved throughout the eukaryotic kingdom. The 4-OH phosphorylated phosphoinositides such as phosphatidylinositol-4-phosphate (PtdIns4P) and phosphatidylinositol-4,5-bisphosphate are particularly important molecules as these execute intrinsically essential activities required for the viability of all eukaryotic cells studied thus far. Using intracellular tachyzoites of the apicomplexan parasite Toxoplasma gondii as model for assessing primordial roles for PtdIns4P signaling, we demonstrate the presence of PtdIns4P pools in Golgi/trans-Golgi (TGN) system and in post-TGN compartments of the parasite. Moreover, we show that deficits in PtdIns4P signaling result in structural perturbation of compartments that house dense granule cargo with accompanying deficits in dense granule exocytosis. Taken together, the data report a direct role for PtdIns4P in dense granule biogenesis and exocytosis. The data further indicate that the biogenic pathway for secretion-competent dense granule formation in T. gondii is more complex than simple budding of fully matured dense granules from the TGN. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv cell biology
Trafficking of nuclear-encoded apicoplast proteins depends on F-actin and Myosin F in Toxoplasma gondii

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jan 2, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.01.521342v1?rss=1 Authors: Devarakonda, P. M., Sarmiento, V., Heaslip, A. T. Abstract: Toxoplasma gondii contains an essential single plastid organelle known as the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function leads to parasite death. To maintain a functional apicoplast, the parasite must execute two important cellular processes: accurate division of this single copy organelle into daughter parasites during cell division and trafficking of nuclear encoded apicoplast proteins (NEAT). In this study we demonstrate that F-actin and an unconventional myosin motor, TgMyoF, are important for both processes. Live cell imaging demonstrates that during division the apicoplast is highly dynamic, exhibiting branched, U-shaped and linear morphologies that are dependent on TgMyoF and actin. These dynamics appear to control apicoplast association with the centrosome and positioning of the centrosome at the apicoplast tips. Loss of apicoplast dynamics correlated with reduced apicoplast-centrosome association and ultimately apicoplast inheritance defects. In addition, we uncovered the role of TgMyoF and actin in NEAT protein trafficking. Vesicles containing the apicoplast protein APT1 were only observed during apicoplast division in control parasites, however loss of TgMyoF and actin lead to accumulation of vesicles in the cytosol, with only a small impact on vesicle movement suggesting that this actomyosin system is important for vesicle fusion with the apicoplast. Consequently, loss of TgMyoF resulted in reduced apicoplast length. This study has provided crucial new insight into mechanisms and timing of protein trafficking to the apicoplast and demonstrated how apicoplast-centrosome association, a key step in the apicoplast division cycle, is control by the actomyosin cytoskeleton. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

C'est pas la grande forme!
Bottes d’hiver, Papa Noël et mitaines de four… [S03E16]

C'est pas la grande forme!

Play Episode Listen Later Dec 2, 2022 30:22


Cette semaine à l'émission: Le mot “agrémenté”, Opération Nez Rouge: stratagème, Les mitaines de four, Selena Gomez: ça va pas!, Toxoplasma Gondii, L'épuisement professionnel, Les … The post Bottes d'hiver, Papa Noël et mitaines de four… [S03E16] first appeared on C'est pas la grande forme!.

Hora 25
El parásito que puede cambiar el comportamiento de una comunidad de lobos: así es el 'toxoplasma gondii'

Hora 25

Play Episode Listen Later Nov 24, 2022 4:16


El toxoplasma gondii es un parásito que se reproduce en el tracto digestivo de los felinos y que, según un estudio publicado hoy en la revista 'Communications biology' es capaz de modificar el comportamiento de algunos animales y, por tanto, de sus sociedades

PaperPlayer biorxiv cell biology
Structural analysis of Toxoplasma gondii sortilin

PaperPlayer biorxiv cell biology

Play Episode Listen Later Nov 21, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.17.516902v1?rss=1 Authors: Honfozo, A., Ghouil, R., Alayi, T. D., Ouldali, M., Arteni, A.-A., Atindehou, C. M., Fanou, L. A., Hathout, Y., Zinn-Justin, S., Tomavo, S. Abstract: Rhoptries and micronemes are essential for host cell invasion and survival of all apicomplexan parasites, which are composed of numerous obligate intracellular protozoan pathogens including Plasmodium falciparum (malaria) and Toxoplasma gondii (toxoplasmosis) that infect humans and animals causing severe diseases. We identified Toxoplasma gondii TgSORT as an essential cargo receptor, which drives the transport of rhoptry (ROP) and microneme (MIC) proteins to ensure the biogenesis of these secretory organelles. The luminal ectodomain of 752 amino acid long situated at the N-terminus end of TgSORT has been described to bind to MIC and ROP proteins. Here, we present an optimized protocol for expression of the entire luminal ectodomain of TgSORT (Tg-NSORT) in the yeast Pichia pastoris. Optimization of its coding sequence, cloning and transformation of the yeast P. pastoris allowed the secretion of Tg-NSORT. The protein was purified and further analyzed by negative staining electron microscopy. In addition, molecular modeling using AlphaFold identified key differences between human and T gondii sortilin. The structural features that are only present in T. gondii and other apicomplexan parasites were highlighted. Elucidating the roles of these specific structural features may be useful for designing new therapeutic agents against apicomplexan parasites. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The Judgies
Ep 124: We're Sorry Larry

The Judgies

Play Episode Listen Later Oct 24, 2022 75:02


In This Episode: We discuss the BTS Army, Erika and her work/family updates, mail time, a  person wanting their gifts back after an unsuccessful childbirth, a girlfriend who only wants kids that are tall and white, a husband who keeps using his wife's blanket to catch his "stuff," and a GF getting pregnant against the rules of the threelationship. We also go over the parasite that sells motorcycles known as "Toxoplasma Gondii." Go to babbel.com/judgies for 55% off your subscription! Get Judgies Merch Here: https://store.streamelements.com/judgiespod Our Patreon is officially open, if you want to see extra content go check it out!  https://www.patreon.com/JudgiesPod  Send us mail! (Addressed However You'd Like)  P.O. Box 58 Ottawa, IL 61350  Leave a Review!  https://podcasts.apple.com/us/podcast/the-judgies/id1519741238  Follow us on Twitter: https://twitter.com/judgiespod Follow us on Instagram: https://instagram.com/judgiespod  Intro Music by: Iván  https://open.spotify.com/artist/5gB2VvyqfnOlNv37PHKRNJ?si=f6TIYrLITkG2NZXGLm_Y-Q&dl_branch=1  Time Stamps: 0:00 Intro 1:53 BTS Army 3:15 Erika Work and Family 7:14 Mail Time 13:37 Review Time 21:43 Veggie Tales 22:13 Donor  28:29 CJ: Toxo  42:42 LS: Mom's Fakebook 50:47 Husband Using Blanket 1:00:42 Pregnant GF 1:06:03 Outro Learn more about your ad choices. Visit megaphone.fm/adchoices

The Array Cast
Troels Henriksen and Futhark

The Array Cast

Play Episode Listen Later Oct 1, 2022 70:53


Array Cast - September 30, 2022 Show NotesMany thanks to Bob Therriault for gathering these links:[01] 00:03:08 ADSP podcast on K https://adspthepodcast.com/2022/09/23/Episode-96.html[02] 00:03:30 Paradigm Conference 2022 https://esolangconf.com/[03] 00:04:25 Troels Henriksen https://sigkill.dk/[04] 00:05:05 Futhark https://futhark-lang.org/[05] 00:06:12 Linux https://www.linux.org/[06] 00:08:00 Textualize https://www.textualize.io/[07] 00:08:27 Standard ML https://en.wikipedia.org/wiki/Standard_ML Common Lisp https://en.wikipedia.org/wiki/Common_Lisp Haskell https://www.haskell.org/[08] 00:09:50 Cosmin Oancea http://hjemmesider.diku.dk/~zgh600/[09] 00:10:53 Ocaml https://ocaml.org/[10] 00:12:20 Numpy https://numpy.org/ PyTorch https://github.com/pytorch/pytorch[11] 00:13:07 Single Assignment C https://www.sac-home.org/index[12] 00:13:20 Codfns https://github.com/Co-dfns/Co-dfns DEX https://github.com/google-research/dex-lang Accelerate for Haskell https://www.acceleratehs.org Copperhead https://github.com/bryancatanzaro/copperhead Tensorflow https://github.com/tensorflow/tensorflow JAX https://github.com/google/jax[13] 00:18:39 Phd Position https://employment.ku.dk/phd/?show=157471[14] 00:20:17 Experiential Learning https://en.wikipedia.org/wiki/Experiential_learning[15] 00:21:21 DIKU https://di.ku.dk/english/ Hiperfit http://hiperfit.dk/ Simcorp https://en.wikipedia.org/wiki/SimCorp Dyalog https://www.dyalog.com/[16] 00:23:00 TAIL http://hiperfit.dk/pdf/array14_final.pdf apltail https://github.com/melsman/apltail Martin Elsman https://elsman.com/[17] 00:29:17 Parametric Polymorphism https://en.wikipedia.org/wiki/Parametric_polymorphism[18] 00:32:06 Jay Foad https://aplwiki.com/wiki/Jay_Foadhttps://docs.dyalog.com/latest/Compiler%20User%20Guide.pdf[19] 00:33:00 Tacit Programming https://aplwiki.com/wiki/Tacit_programming[20] 00:36:30 Mandelbrot set https://en.wikipedia.org/wiki/Mandelbrot_set[21] 00:41:07 Typed Array Languages https://mlochbaum.github.io/BQN/implementation/compile/intro.html#typed-array-languages[22] 00:42:05 Leading Axis Array Theory https://aplwiki.com/wiki/Leading_axis_theory[23] 00:43:56 Ken Iverson https://en.wikipedia.org/wiki/Kenneth_E._Iverson[24] 00:49:25 Conor's Array Comparison https://github.com/codereport/array-language-comparisons[25] 00:49:50 APEX https://gitlab.com/bernecky/apex Bob Bernecky https://www.snakeisland.com/[26] 00:51:05 Second Order Array Combinators https://futhark-book.readthedocs.io/en/latest/language.html[27] 00:52:30 Associativity https://en.wikipedia.org/wiki/Associative_property Commutativity https://en.wikipedia.org/wiki/Commutativity[28] 00:56:12 Toxoplasma Gondii https://en.wikipedia.org/wiki/Toxoplasma_gondii[29] 00:59:20 Guy Blelloch https://en.wikipedia.org/wiki/Guy_Blelloch Nesl http://www.cs.cmu.edu/~scandal/nesl.html[30] 01:00:38 Remora https://www.ccs.neu.edu/home/jrslepak/typed-j.pdf Justin Slepak https://jrslepak.github.io/[31] 01:01:12 Conor's Venn diagram https://github.com/codereport/array-language-comparisons[32] 01:02:40 K https://aplwiki.com/wiki/K Kona https://aplwiki.com/wiki/Kona[33] 01:03:20 April https://aplwiki.com/wiki/April Andrew Sengul Episode on Array Cast https://www.arraycast.com/episodes/episode23-andrew-sengul[34] 01:04:40 Py'n'APL https://github.com/Dyalog/pynapl APL.jl https://aplwiki.com/wiki/APL.jl May https://github.com/justin2004/may Julia https://julialang.org/[35] 01:08:05 Bjarne Stroustrup C++ https://www.stroustrup.com/[36] 01:09:16 Artem Shinkarov https://ashinkarov.github.io/ Sven-Bodo Scholz https://www.macs.hw.ac.uk/~sbs/homepage/main/Welcome.html https://www.microsoft.com/en-us/research/video/sac-off-the-shelf-support-for-data-parallelism-on-multicores/[37] 01:10:19 Contact AT ArrayCast DOT com

L'innovation du jour - Anicet Mbida
Toxoplasma Gondii : un virus qui rend beau

L'innovation du jour - Anicet Mbida

Play Episode Listen Later Aug 29, 2022 1:47


Anicet Mbida nous livre chaque matin ce qui se fait de mieux en matière d'innovation. Ce lundi, il s'intéresse au virus Toxoplasma Gondii. Il s'agit d'un parasite étonnant puisqu'il agit positivement sur le physique des personnes l'ayant contracté.

Animal Radio®
1159. Sheena Easton Goes Crazy About Her Cats!

Animal Radio®

Play Episode Listen Later Feb 17, 2022 79:52


Accidentally Sickening Your Pet The Senior Veterinary Toxicologist at the Pet Poison Helpline wants you to know what household toxins can fatally sicken your pets. Dr. Ahna Brutlag warns that pesticides and bait traps can kill more than bugs and mice. She also says even pet safe anti-freeze can be harmful. Listen Now Psychologist Tells Us What Pets Want From Their Owners Ever wonder how your pet sees the world? There's an entire branch of science devoted to figuring that out. Psychologist Dr. Zazie Todd has been studying the techniques guardians use to better their relationship with their pets. Listen Now Toxoplasmosis Could Actually Improve Your Life According to a new study, a mind-controlling parasite found in cat feces increases a person's likelihood of studying business and going into entrepreneurial-related careers. The parasite Toxoplasma Gondii has long been associated with impulsive behaviors leading to an increased risk of car accidents, road rage, mental illness, neuroticism, drug abuse and even suicide. Researchers believe T. Gondii exposure might push people toward higher risks and higher reward activities. The experts found that people infected with the parasite were about 1.5 times more likely to major in business and 1.7 times more likely to pursue a management and entrepreneurship major. Listen Now Pop Diva Sheena Easton Flashback Singer, songwriter and actress Sheena Easton provides one of the most memorable celebrity interviews on Animal Radio. Sheena is cra-cra about her kitties, no holds barred when she divulges how she spoils her cats and dogs. Listen Now Read more about this week's show.

Science Night
The 2021 Science Night Halloween Spectacular!

Science Night

Play Episode Listen Later Oct 29, 2021 48:27


Beware dear listener, this episode of the Science Night podcast is much spookier than our typical offering. We begin our descent into the strange by talking about the scientific origins of the lore of our favorite monsters with special guest, Bill Sullivan (https://authorbillsullivan.com/). Later, the bravest among you can stay tuned for a dramatic reading of "Bit" from the twisted mind of Cody Sullivan (https://twitter.com/codyasullivan), host of fellow Riverpower Podcast Mill show, Pulp: From Beyond the Veil (https://www.pulpfrombeyond.com/). Special Guest: BILL SULLIVAN (https://authorbillsullivan.com/) is a professor of pharmacology and microbiology at the Indiana University School of Medicine in Indianapolis, where he studies infectious disease and genetics. An award-winning researcher, teacher, and science communicator, Sullivan has been featured in a wide variety of outlets, including CNN, Fox & Friends, National Geographic, Scientific American, COSMOS magazine, Science Fantastic with Dr. Michio Kaku, The Naked Scientists, and The Scientist. "Bit"- Written by C.A. Sullivan Voice Cast: Nick- Cody Sullivan, EBS Announcer- James Reed, Additional Voices- Cody Sullivan Music: Tormented Souls (Horror Soundscape) by Myuu | https://soundcloud.com/myuu Music promoted by https://www.free-stock-music.com | Creative Commons Attribution 3.0 Unported License https://creativecommons.org/licenses/by/3.0/deed.en_US Maleficus by Scott Buckley | https://soundcloud.com/scottbuckley | Music promoted by https://www.free-stock-music.com Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/ Your Hosts: Jason Organ (https://twitter.com/OrganJM) James Reed (https://twitter.com/James_Reed3) Credits Editing and Mastering-James Reed & Cody Sullivan Music: Intro - Lyra Mortis by Loopop | https://www.youtube.com/channel/UC-RA5BzE_BnZhf5iVdNF1hA | Standard YouTube License Wolf Moon by Unicorn Heads | https://unicornheads.com/ | Standard YouTube License Additional Sounds- Inside a Computer Chip by Doug Maxwell | https://www.mediarightproductions.com/ | Standard YouTube License Sound Effects | YouTube Audio Library | Standard YouTube License The Science Night Podcast is a member of the Riverpower Podcast Mill (https://riverpower.xyz/) family

Last Call with Chris Michaels
Follow me on this; Toxoplasma Gondii

Last Call with Chris Michaels

Play Episode Listen Later Sep 28, 2021 45:11


What are the physical symptoms of the parasite, Toxplasma Gondii? What are the neurological and mental symptoms of Toxoplasma Gondii? How do you test for it? How do you treat it…a parasite? Was C0vid really just Toxoplasma Gondii unleashed? Have they turned the whole population into masochists? Hold onto your nuts and labias! --- Support this podcast: https://anchor.fm/lastcallwithchrismichaels/support

Last Call with Chris Michaels
Follow me on this; Toxoplasma Gondii

Last Call with Chris Michaels

Play Episode Listen Later Sep 28, 2021 45:11


What are the physical symptoms of the parasite, Toxplasma Gondii? What are the neurological and mental symptoms of Toxoplasma Gondii? How do you test for it? How do you treat it…a parasite? Was C0vid really just Toxoplasma Gondii unleashed? Have they turned the whole population into masochists? Hold onto your nuts and labias! --- Support this podcast: https://anchor.fm/lastcallwithchrismichaels/support

Health Report - ABC RN
Can substituting salt save lives?; the science of the COVID modelling; and Toxoplasma Gondii and cognitive decline

Health Report - ABC RN

Play Episode Listen Later Aug 30, 2021 36:17


What new research shows about the effect of substituting salt and health - can it save lives?

Holobiont
#7 The Multiple Lives of Toxoplasma gondii (Pascale Guiton)

Holobiont

Play Episode Listen Later Jul 2, 2021 38:45


Dr Pascale Guiton, an Assistant Professor at California State University, tells us about the fascinating biology of Toxoplasma gondii, a widely spread protozoan parasite that infects most warm blooded mammals and can cause severe disease in foetuses and immunocompromised hosts. We discuss how Toxoplasma gondii can modulate the behaviour of its hosts, why its sexual reproduction cycle only occurs in felines, the inflammatory response it elicits and its complex mechanisms of genome regulation. A diagram of the complex life-cycle of the parasite will be helpful to follow this discussion (https://www.researchgate.net/figure/Life-cycle-of-T-gondii-Sexual-and-asexual-reproduction-of-Toxoplasma-take-place-in_fig1_337784380) Links to the articles discussed: Neuroinflammation- associated alteration of fear in mice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963786/ Enzymes determining host range for sexual reproduction: https://pubmed.ncbi.nlm.nih.gov/31430281/ The MORC protein in sexual commitment: https://www.nature.com/articles/s41564-020-0674-4 To follow up on Pascale Guiton's research: https://guitonlab.com

Shut Up! Keep Going
Poisoned Bootlegged Liquor + Toxoplasma Gondii: Lethal Alcohol Courtesy of the US Gov't and a Mind-Controlling Parasite

Shut Up! Keep Going

Play Episode Listen Later Jan 29, 2021 63:06


This week, the Kate and Syd delve into stories of lethal intoxication and parasitic mind-control. Kate transports us back to the prohibition era to share the little-known history of the U.S. Government's strategic liquor poisoning campaign. Then, Sydnee frightens us with Toxoplasma gondii, a parasite that controls minds. Yeah, now that's another thing to worry about. We now have an Instagram! Give us a follow: https://www.instagram.com/shutupkeepgoing/ (www.instagram.com/shutupkeepgoing)

Biologists Being Basic
Episode 10: Toxoplasma Gondii Part 2: Pascale Guiton, The Scientist Leading the Research

Biologists Being Basic

Play Episode Listen Later Dec 9, 2020 42:03


In this episode, Biologists Being Basic (B3) hosts Paige, Gina and Robyn continue their conversation with special guest, Professor Pascale Guiton. Join us for a candid discussion about her path to science, her career in academia, her advocacy of BIPOC voices in STEM, and the importance of diversity, representation, inclusion and equity in the sciences. Further Resources: We highly recommend visiting Professor Guiton’s website, where you can find her publications and keep up with her latest science and BIPOC advocacy highlights: https://guitonlab.com/ In addition, if you are interested in the teaching material that was discussed in the episode, you can find the resource here: https://edarxiv.org/s9wkv/

First Past the Post
Toxoplasma Gondii

First Past the Post

Play Episode Listen Later Dec 2, 2020 0:51


This episode covers toxoplasma gondii!

Biologists Being Basic
Toxoplasma Gondii Part 1: The Cat Parasite

Biologists Being Basic

Play Episode Listen Later Nov 11, 2020 53:23


In this episode, Biologists Being Basic (B3) hosts Paige, Gina and Robyn talk to special guest, Professor Pascale Guiton, about her research on the fascinating life cycle of Toxoplasma gondii. In part one, we take a deeper look into the science behind the king of parasites. Further Resources: For further information on topics we talked about in Episode 7: Part 1, we highly recommend visiting Professor Guiton’s website and looking into her publications: https://guitonlab.com/ In addition, you can watch Dr. Guiton talk about Toxoplasma gondii and her research on QBI TV: https://www.youtube.com/watch?v=ckixqEbxZfs For another look at Gina’s question (does this parasite make her love cats so much), check out this Ted-Ed video: https://www.youtube.com/watch?v=rqno7K2zXi4 Dr. Guiton references work by Dr. Laura Knoll’s team on the role of delta-6-desaturase in Toxoplasma sexual reproduction: https://pubmed.ncbi.nlm.nih.gov/31430281/ ...and also discusses this study by Vyas et al on the behavioral changes induced by Toxoplasma infection in mice: https://pubmed.ncbi.nlm.nih.gov/17404235/ Concerned about toxoplasmosis and pregnancy? No you don’t have to give up your cat, instead visit the CDC for more info: https://www.cdc.gov/parasites/toxoplasmosis/gen_info/pregnant.html Dr. Guiton mentioned the call for a One Health framework to study Toxoplasma gondii, described in this review: https://link.springer.com/article/10.1007/s10393-019-01405-7 ...and references fluorescent staining of Toxoplasma gondii done by Dr. Sebastian Lourido. For cool videos and images of brightly colored Toxo (and coverage of his most recent research), watch this feature: https://www.youtube.com/watch?v=HOnhthD3yz4 We talked about Antoni van Leeuwenhoek, who was the first to observe microscopic organisms (“animalcules”): https://www.nationalgeographic.com/news/2016/07/antoni-leeuwenhoek-microbe-microscope-discovery-contribution/ Still fascinated by parasites and want to learn more? Check out this “hilarious and ever-so-slightly creepy” Ted talk by Ed Yong, who describes the biology behind a handful of parasites (including Toxo): https://www.ted.com/talks/ed_yong_zombie_roaches_and_other_parasite_tales?utm_campaign=tedspread&utm_medium=referral&utm_source=tedcomshare If you have any questions or comments you can email us at biologistsbeingbasic@gmail.com or find us on twitter or instagram (@biosbeingbasic).

Curiosity Daily
Could Parasites Turn Us into Zombies?

Curiosity Daily

Play Episode Listen Later Oct 23, 2020 13:52


Learn about whether parasites can turn us into zombies, why awkward silences are so awkward, and why bubbles form in boiling water. Could parasites turn us into zombies? By Cameron Duke Ahmed, I. (2019, November). The science of zombies: Will the undead rise? Phys.Org; Phys.org. https://phys.org/news/2019-11-science-zombies-undead.html Blum, J., Schmid, C., & Burri, C. (2006). Clinical aspects of 2541 patients with second stage human African trypanosomiasis. Acta Tropica, 97(1), 55–64. https://doi.org/10.1016/j.actatropica.2005.08.001 Flegr, J. (2007). Effects of Toxoplasma on Human Behavior. Schizophrenia Bulletin, 33(3), 757–760. https://doi.org/10.1093/schbul/sbl074 McAuliffe, K. (2012, February 6). How Your Cat Is Making You Crazy. The Atlantic. https://www.theatlantic.com/magazine/archive/2012/03/how-your-cat-is-making-you-crazy/308873/ Pappas, S. (2011, October 20). Unrelenting Sex Drive May Signal Deadly Rabies. Livescience.Com; Live Science. https://www.livescience.com/16627-sex-drive-rabies-infection.html Thomas, B. (2015, October 29). Meet the Parasites That Control Human Brains. Discover Magazine. https://www.discovermagazine.com/planet-earth/meet-the-parasites-that-control-human-brains The Science of Awkward Silences by Anna Todd Koudenburg, N., Postmes, T., & Gordijn, E. H. (2011). Disrupting the flow: How brief silences in group conversations affect social needs. Journal of Experimental Social Psychology, 47(2), 512–515. https://doi.org/10.1016/j.jesp.2010.12.006  Koudenburg, N., Postmes, T., & Gordijn, E. H. (2013). Resounding Silences. Social Psychology Quarterly, 76(3), 224–241. https://doi.org/10.1177/0190272513496794  Why do bubbles form in boiling water? by Ashley Hamer (Listener question from Abu) UCSB Science Line. (2020). Ucsb.Edu. http://scienceline.ucsb.edu/getkey.php?key=3197  Why Does Water Bubble When It Boils? (2019, November 2). Wonderopolis.Org. https://wonderopolis.org/wonder/why-does-water-bubble-when-it-boils Helmenstine, A.M. (2019). Know the Chemical Composition of Bubbles in Boiling Water. ThoughtCo. https://www.thoughtco.com/what-are-the-bubbles-in-boiling-water-4109061 Breslyn, W. (2016). Boiling, Atmospheric Pressure, and Vapor Pressure [YouTube Video]. In YouTube. https://www.youtube.com/watch?v=Ag4lLUXKuSM  ‌FAQ: Boiling and altitude/pressure. (2020). IAPWS.org. http://www.iapws.org/faq1/boil.html  Subscribe to Curiosity Daily to learn something new every day with Ashley Hamer and Natalia Reagan (filling in for Cody Gough). You can also listen to our podcast as part of your Alexa Flash Briefing; Amazon smart speakers users, click/tap “enable” here: https://www.amazon.com/Curiosity-com-Curiosity-Daily-from/dp/B07CP17DJY  See omnystudio.com/listener for privacy information.

Hey, Lesson!
Do you have a brain parasite? (Baldur’s Gate 3)

Hey, Lesson!

Play Episode Listen Later Oct 21, 2020 41:39


Baldur's Gate 3 sees your hero coping with a horrible brain parasite. But you might already be infected in real life (don't worry, it's not that bad)

Zombified: A production of ASU and Zombie Apocalypse Medicine
The Toxopocalypse: Jessica Brinkworth

Zombified: A production of ASU and Zombie Apocalypse Medicine

Play Episode Listen Later Oct 3, 2020 80:43


We've all seen how disease changes our behavior, but did you know that there are diseases that actually hijack our brains? In this episode we talk with immunologist and evolutionary anthropologist Jessica Brinkworth about the parasite toxoplasma gondii, perhaps best known for it's presence in kitty litter. Jessica explains the many ways that toxo zombifies us and other mammals, hijacking even our own cells to make them little zombies bent on perpetuating toxo. Toxoplasma gondii also plays a role in human behavior, affecting risk taking behaviors and vulnerability to schizophrenia. The toxopocalypse expands even outwards to the ecosystems we are embedded within, threatening species in our oceans and beyond. If you've ever wondered what evil lurks in your cat box, you'll definitely want to listen to this episode.

iBiology Videos
Sebastian Lourido Part 2: Genetic Approaches to Study Toxoplasma gondii

iBiology Videos

Play Episode Listen Later Sep 26, 2020 28:57


Since little is known about the Toxoplasma gondii genome, in his second iBiology seminar, Lourido explains how his lab developed CRISPR tools to study apicomplexan biology. His lab designed a strain of T. gondii constitutively expressing Cas9 that can be used in conjunction with guide libraries to identify biologically significant genes. Lourido explains how his lab used this system to identify genes encoding proteins necessary for apicomplexan invasion. These include a claudin-like protein, that they are calling CLAMP, that is conserved across apicomplexa and is necessary for invasion by both toxoplasma and the parasites that cause malaria.  

PaperPlayer biorxiv neuroscience
Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Aug 31, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.31.274985v1?rss=1 Authors: Leite, P. E. C., Portes, J. d. A., Pereira, M. R., Russo, F. B., Martins-Duarte, E. S., dos Santos, N. A., Attias, M., Barrantes, F. J., Beltrao-Braga, P. C. B., de Souza, W. Abstract: Background: Toxoplasmosis is caused by the parasite Toxoplasma gondii that can infect the central nervous system (CNS), promoting neuroinflammation, neuronal loss, neurotransmitter imbalance and behavioral alterations. T. gondii infection is also related to neuropsychiatric disorders such as schizophrenia. The pathogenicity and inflammatory response in rodents are different to the case of humans, compromising the correlation between the behavioral alterations and physiological modifications observed in the disease. In the present work we used BrainSpheres, a 3D CNS model derived from human pluripotent stem cells (iPSC), to investigate the morphological and biochemical repercussions of T. gondii infection in human neural cells. Methods: We evaluated T. gondii ME49 strain proliferation and cyst formation in both 2D cultured human neural cells and BrainSpheres. Aspects of cell morphology, ultrastructure, viability, gene expression of neural phenotype markers, as well as secretion of inflammatory mediators were evaluated for 2 and 4 weeks post infection in BrainSpheres. Results: T. gondii can infect BrainSpheres, proliferating and inducing cysts formation, neural cell death, alteration in neural gene expression and triggering the release of several inflammatory mediator. Conclusions: BrainSpheres reproduce many aspects of T. gondii infection in human CNS, constituting a useful model to study the neurotoxicity and neuroinflammation mediated by the parasite. In addition, BrainSpheres can be an important tool for better understanding the possible correlation between psychiatric disorders and human CNS infection with T. gondii. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv animal behavior and cognition
Toxoplasma gondii infections are associated with boldness towards lions in wild hyena hosts

PaperPlayer biorxiv animal behavior and cognition

Play Episode Listen Later Aug 27, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.26.268805v1?rss=1 Authors: Gering, E., Laubach, Z. M., Weber, P., Hussey, G. S., Lehmann, K. D. S., Montgomery, T. M., Turner, J. W., Perng, W., Pioon, M. O., Holekamp, K. E., Getty, T. Abstract: Toxoplasma gondii is widely reported to manipulate the behavior of its non-definitive hosts in ways that promote lethal interactions with the parasite's definitive feline hosts. Nonetheless, there is a lack of data on the association between T. gondii infection and costly behavioral interactions with felids in nature. Here, we report that three decades of field observations reveal T. gondii infected hyena cubs approach lions more closely than uninfected peers and have higher rates of lion mortality. Our findings support the hypothesis that T. gondii's manipulation of host boldness is an extended phenotype that promotes parasite transmission from intermediate hosts to feline predators. While upregulating hyena boldness toward lions might achieve this, it may also reflect a collateral influence of manipulative traits that evolved in other hosts (e.g., rodents). In either case, our findings corroborate the potential impacts of a globally distributed and generalist parasite (T. gondii) on fitness-related interaction with felids in a wild host. Copy rights belong to original authors. Visit the link for more info

La Ciencia Pop
S01E17 | Una historia de miedo

La Ciencia Pop

Play Episode Listen Later Jun 26, 2020 24:37


El miedo es una emoción desagradable que es causada por una amenaza o peligro... real o imaginario. El miedo genera comportamientos defensivos y respuestas fisiológicas que tienden a maximizar la supervivencia de un organismo, nos ayuda a lucha o escapar y, en casos extremos, nos puede paralizar. El miedo nos ayuda a sobrevivir, pero también nos puede impedir aprender cosas nuevas. Hay personas que parecen manejar el miedo de manera diferente y hay otras en las que producto de lesiones cerebrales específicas, se ha alertado completamente la percepción del miedo. Un caso particularmente llamativo es el de ratones que parecen haberles perdido el miedo a los gatos y lo más curioso de esto es que ese cambio en el comportamiento se asocia con un parásito que forma quistes en el cerebro de los ratones. Del miedo y su ausencia es la historia de hoy en La ciencia pop *** La Ciencia Pop cuenta con el auspicio de CGESTA, gerenciamiento e inspección técnica de alta eficiencia para proyectos de construcción, con más de 2 millones de metros cuadrados de experiencia en los ámbitos de retail, industrial, oficinas, salud, educación e inmobiliario. Para más información, visite la página www.cgesta.cl ***Support the show (https://www.patreon.com/LaCienciaPop)

Wiki Review
87 – 2019–20 coronavirus pandemic

Wiki Review

Play Episode Listen Later Apr 19, 2020 92:36


Ben and Garth review the Wikipedia page for 2019–20 coronavirus pandemic. Oh, ah, ah, ah, ah, get up, come on get down with the sickness. Wow this is legit happening right now. Karama for the toilet paper hoarders and a clean-up for the business world. Prepping for the preppers. Taking the time to watch Tiger King and The Platform, the difference between polygamy and bigamy and the Tiger King might have Toxoplasma Gondii. Other countries can be racist too #chinesedontcometojapan. The sarcasm behind “quotes”. Email scams, cure scams, home test scams, prevention scams and 5G scams. Garth's Corona virus sketch - https://soundcloud.com/garth-remington/four-yorkshiremen-covid19-edition?fbclid=IwAR2lhv3wl3etAimhYezP3HktccvFM6A5xlOUYxqhVAZkeIridqp7abzFgNI Ben’s Auto Mario - HG5 JSF TYF https://en.wikipedia.org/wiki/Easter_egg_(media) Humour Door Facebook: https://www.facebook.com/HumourDoor Humour Door YouTube: https://www.youtube.com/channel/UCr5ucoBBUNfpjLfc0EWM0ww Humour Door Instagram: https://www.instagram.com/humourdoor/ Humour Door Twitter: @thehumourdoor humourdoor.com.au wikireviewpodcast@gmail.com Theme: I Live For The Bass Drum - DJ S3rl https://djs3rl.com Art Work: https://www.instagram.com/bjo0se/

Viral Load
Toxoplasma Gondii: the 'Mind-Control' Parasite

Viral Load

Play Episode Listen Later Apr 13, 2020 81:34


On this week's Viral Load, Brett and Andy are back in the world of parasites. Are you a cat lover? You're in luck, so does the "mind control" parasite Toxoplasma gondii. Tune in to find out why you really shouldn't f**ck with cats!...References: https://www.livescience.com/56529-strange-facts-about-toxoplasma-gondii-parasite.htmlhttps://www.livescience.com/toxoplasmosis.htmlhttps://theconversation.com/toxoplasma-cat-poo-parasite-infects-billions-so-why-is-it-so-hard-to-study-120688https://jeb.biologists.org/content/216/1/127.longhttps://www.livescience.com/65038-why-usda-conducted-experiments-cat-cannibalism.htmlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023277https://www.livescience.com/54141-toxoplasmosis-parasite-linked-with-rage-disorder.html

Finding Genius Podcast
Toxoplasma Gon ‘n Did It Again (A Microscopic Look at the Behavior of Toxoplasma Gondii)—William J. Sullivan, PhD—Showalter Professor of Pharmacology & Toxicology at Indiana University School of Medicine

Finding Genius Podcast

Play Episode Listen Later Mar 17, 2020 38:28


Professor and author of Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are, joins the show for a second time today to discuss parasites, focusing on one in particular that affects a significant number of people: Toxoplasma gondii. By tuning in, you'll discover the following: How Toxoplasma gondii enters a cell and then replicate exponentially Why brain tissue is a common place for Toxoplasma gondii to end up, how the parasite behaves once in neurons and nuclei, and how these locations protect it from the host's immune system and drug interventions How Toxoplasma gondii initiates a starvation response in a host cell in order to obtain even more food without further effort As a graduate student at University of Pennsylvania, Dr. Sullivan had already had a longstanding interest in microbiology when he began doing lab rotations that would ultimately help him develop his PhD thesis. It was during that time that he discovered toxoplasma gondii, microscopic banana-shaped organisms squirming their way through fibroblast cells and growing exponentially until blowing apart the host cell. At the time, Dr. Sullivan was absolutely fascinated by these organisms, and decided to pursue research on them from there on out.  He wanted to know the details of how Toxoplasma gondii functions and how it could be impacting human health, so he was particularly excited to learn that a professor in the lab was working on turning Toxoplasma gondii into one of the first model systems for all of parasitology. This would allow for modern-day cell and molecular genetic techniques to be employed—a feat impossible for most other parasites. This would pave the way for avenues of unprecedented research in parasitology. “Toxoplasma gondii is pretty remarkable…many people call it the most successful parasite on the planet because it can infect any nucleated cell in virtually any warm-blooded vertebrate…most parasites have a single host, maybe two hosts,” he explains. Among many topics, Dr. Sullivan explains what type of evidence suggests that Toxoplasma gondii is able to recognize what type of host cell it is in, how the active invasion process works, how long it takes before a host immune response is initiated by the presence of Toxoplasma gondii, how this parasite can affect host behavior and personality, how long the latent stages of the infection can last, and what's being done to address human health concerns posed by this parasite. Check out www.sullivanlab.com for more information.

Finding Genius Podcast
New Discoveries about the Life Cycle of Toxoplasma Gondii—Laura Knoll, PhD—Department of Medical Microbiology & Immunology at the University of Wisconsin-Madison

Finding Genius Podcast

Play Episode Listen Later Feb 21, 2020 40:51


Professor Laura Knoll is a parasitologist who joins the podcast today to discuss some of her research on a type of parasite called toxoplasma gondii. She explains the following: Where toxoplasma gondii is found and why the sexual stage of its life cycle is only found in cats How humans can become infected with toxoplasma gondii, and why most people will never know they are affected and may never need toxoplasma gondii treatment How toxoplasma gondii has evolved mechanisms to manipulate the host, such as a rodent that loses its fear of predator urine and actually becomes attracted to it Toxoplasma gondii is a parasite that can infect every warm-blooded animal on the planet, including humans. This parasite has the fascinating ability to enter muscle tissue and neurons in the brain to enact behavioral changes in the host. For example, a rodent infected with toxoplasma gondii will be attracted to the scent of predator urine rather than fearful of it, thereby exposing themselves to predation and allowing the parasite to continue thriving in other hosts—such as the cat. Interestingly, the cat intestine is the only place where the sexual life cycle stage of toxoplasma gondii is found, which means the cat can shed infectious oocysts which can potentially put humans at risk of contracting toxoplasma gondii. However, Dr. Knoll explains that the vast majority of people who are chronically infected with this parasite have no idea, and suffer no negative consequences. She explains how it can become a problem in people who have compromised immune systems, and the mechanism of host-parasite interaction that can occur in non-human animals and pregnant women who have never before been exposed to the parasite. Until this past year, there was no way to research the sexual life cycle of toxoplasma gondii without using cats as research subjects, but thanks to Dr. Knoll and her team, the specific reason that the sexual stage only occurs in cats has been identified, which has enabled them to induce the sexual stage in mice. With a mouse model, the opportunities for research have increased significantly and paved the way for the potential development of vaccines that could be administered to cats and livestock that carry and can pass on infectious oocytes. For more, visit https://mmi.wisc.edu/staff/knoll-laura/.

Animal Radio®
1045. View Co-host Joy Behar Says "Sleep With Your Dogs!"

Animal Radio®

Play Episode Listen Later Dec 12, 2019 77:56


Joy Behar Guests She has strong opinions, especially when it comes to letting her pets in bed with her. The View's Joy Behar is our special guest and she tells all about her furry family. She's a talented comedian and writer, and she couldn't care less what trainers say about sleeping with your dog. She loves it! Listen Now Recalled Food Contains Plastic Another recall of a canned dog food because of a potential choking risk. The recall affects only weight management varieties, was issued after the discovery of small pieces of blue plastic that entered the food during the production process. Listen Now Kitty Litter Suicides A parasite commonly found in kitty litter boxes could increase a person's risk for suicide. A new study shows the Toxoplasma Gondii parasite causes changes in the brain of an infected person that make them more likely to attempt or commit suicide. Listen Now Thieving Kitty Author Melinda Metz is back with more from the world of Mac, a klepto-kitty with a strong tendency towards stealing things from the neighbors. Listen Now Read more about this week's show.

Achilles' Heel with Alex Hooper
#42: Taking it Personally with Dave Rankin

Achilles' Heel with Alex Hooper

Play Episode Listen Later Nov 4, 2019 101:36


Growing up with three moms, Dave Rankin (new album, Toxoplasma Gondii out 11/7) knows how to be a sweet boy. In this extra silly episode, he breaks down why its difficult to take criticism, how to get through tough break-ups, and why creativity will always fill the void of emptiness. Follow Dave: @_daverankin_ Follow Alex: @hooperhairpuff www.hoopercomedy.com Recorded at the Unfunny Network in Los Angeles, CA 90069

iBiology Videos
Sebastian Lourido Part 1: Toxoplasma gondii: A Model Apicomplexan

iBiology Videos

Play Episode Listen Later Sep 27, 2019 29:52


Apicomplexa are evolutionarily distinct eukaryotes that play an important role in human diseases such as toxoplasmosis and malaria. So how do scientists study their unique biology? Dr. Sebastian Lourido explains that his lab uses Toxoplasma gondii as a model to study the phylum Apicomplexa. In part one of his talk, he explains the complex life cycle of T. gondii and he describes the unique organelles found in apicomplexa and used to facilitate invasion, survival and replication inside host cells. He highlights research from his lab demonstrating the importance of calcium signaling for T. gondii invasion.

Curiosity Daily
Control Your Spending Without a Budget, How Toxo Controls Mice, and Trial By Fire Brilliance

Curiosity Daily

Play Episode Listen Later Aug 29, 2019 10:06


Learn about how the Toxo parasite manipulates mice to get into cats; how the trial by fire was a surprisingly accurate test of guilt; and a trick for figuring out how to spend your money that’s easier than budgeting. In this podcast, Cody Gough and Ashley Hamer discuss the following stories from Curiosity.com to help you get smarter and learn something new in just a few minutes: This Parasite Manipulates Mice to Get Into Cats — And Now Scientists Know Why — https://curiosity.im/31XC3h1  How the Trial by Fire Was a Surprisingly Accurate Test of Guilt — https://curiosity.im/31GuZ8B  If Budgeting Your Money Is Too Hard, Try This Instead — https://curiosity.im/2KmI3di  Download the FREE 5-star Curiosity app for Android and iOS at https://curiosity.im/podcast-app. And Amazon smart speaker users: you can listen to our podcast as part of your Amazon Alexa Flash Briefing — just click “enable” here: https://curiosity.im/podcast-flash-briefing. 

STEM-Talk
Episode 93: Emma Wilson talks about Toxoplasma gondii infection and its consequences

STEM-Talk

Play Episode Listen Later Aug 6, 2019 71:08


Our guest today is Dr. Emma Wilson, a researcher who has spent the past 15 years studying Toxoplasma gondii, a protozoan parasite that infects about a third of the world’s population. She is a native of Scotland and a professor of biomedical science at the University of California, Riverside. Toxoplasma gondii is a single-celled organism found in all mammals. The primary focus of Emma’s research is the immune response in the brain following Toxoplasma gondii infection. Her 2016 research paper in the online journal PLOS Pathogens connected the Toxoplasma gondii to brain dysfunction. Show notes: [00:03:05] Emma begins the interview taking about growing up was born in Glasgow with parents who were in the acting business. [00:03:38] Emma shares how her father advised her to keep all of her doors open, which lead her as a youth to pursue everything she found interesting. [00:04:30] Dawn asks if Emma decided to major in ecology in an effort to help save the rainforests. [00:05:28] Ken asks about Emma’s experience with a “proverbial crazy professor” who showed her a room full of rattlesnakes and how that experience led to Emma’s curiosity in immunology. [00:06:54] Ken asks whether if it’s that she was paid to stand out in the bush so that mosquitos could feast upon her during a research trip to Tanzania. [00:08:16] Ken asks if Emma’s experience in Africa was limited to mosquitos or if she was able to see some of the impressive wildlife there. [00:09:26] Emma discusses her experiences after her research trip to Africa and her decision to pursue work in immunology at Dr. William Harnett’s lab at the University of Strathclyde. [00:10:32] Dawn asks about the research Emma did in Harnett’s lab. [00:11:46] Dawn mentions that Emma had the opportunity to attend a conference in Philadelphia where she met many interesting people. She goes on to ask about the conference and how she ended up spending the next five and a half years at the University of Pennsylvania. [00:13:52] Dawn mentions another conference Emma was able to attend, this one in California, where she stood out for asking so many questions. Dawn asks about how this led her to go to work at University of California, Riverside. [00:16:50] Ken mentions that the primary focus of Emma’s research at Riverside is the immune response in the brain following Toxoplasma gondii infection, further mentioning that in an episode of the podcast “This Week in Parasitism” Dr. Dickson Despommier referred to Toxoplasma gondii as the most successful parasite on Earth. Ken asks Emma to give an overview of what Toxoplasma gondii is and does. [00:18:58] Dawn asks why Toxoplasma gondii has such a high infection rate in countries such as France and Brazil, where close to 80 percent of people are infected. In the U.S., only 15 to 30 percent of people are infected. [00:20:49] Ken mentions that Eskimos, who’s traditional diet is rich in raw meat, have an almost 100 percent infection rate. [00:21:19] Ken asks how the Toxoplasma parasite prevents digestion in the stomach. [00:23:12] Emma discusses how most cases of Toxoplasma in healthy adults present little to no consequences of infection, but that congenitally infected children or people who are immunocompromised can have serious consequences. [00:25:33] Ken asks how an immunocompetent individual keeps the infection at bay and if there is any risk associated with that constantly active immune response in the brain to this infection. [00:27:32] Ken explains that cats are the only definitive host of the toxoplasmosis parasite because it can only complete its sexual reproduction cycle in the gut of a cat. He goes on to explain that cats eat rats, and sometimes rats eat cat feces, which infects the rats with Toxoplasma gondii, When the cats eat these rats the cats perpetuate the cycle. Ken asks Emma to explain how the infection changes the fundamental fear response in rodents that they naturally have ...

Fort Fritz:  Campfire Tales
The Parasite Toxoplasma gondii

Fort Fritz: Campfire Tales

Play Episode Listen Later Jul 14, 2019 9:04


The Parasite Toxoplasma gondii as presented by Fort Fritz: Campfire TalesNarrated by Kaz on Land of the Lost Cause

Too Many Jams
S2 Ep. 19 - 10,000 Club

Too Many Jams

Play Episode Listen Later May 7, 2019 43:59


Hypnosis, is it real? Responding to a strangers group text messages, what happens when it backfires? Ever hear of a Toxoplasma Gondii - a parasite from cat poop that controls your mind? Neither did Robbie. All stuff learned in this week's episode. See y'all next Tuesday. Promo Code: "JAMS15" for 15% off at www.wrist-rye.com For those who enjoyed listening, subscribe to our channel on iTunes or Google Play! Like us on Facebook and leave a review if you feel so inclined as well! All Links are listed below. Website ▶▶ www.toomanyjams.com/ Facebook ▶▶ www.facebook.com/TooManyJams/ Soundcloud ▶▶ @toomanyjams2 iTunes ▶▶ itunes.apple.com/us/podcast/i... GooglePlay ▶▶ goo.gl/kH5vZD

The Cabral Concept
960: Precursors to Parkinson's, Morning Movements, Fatty Liver Detox, Collagen Support, Alcohol Reaction, Consult on Labs, Parasites, Stomach Discomfort (HouseCall)

The Cabral Concept

Play Episode Listen Later Sep 22, 2018 24:44


Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:  Anonymous: Hi, Dr. Cabral, Thank you for your informative podcasts. What a true service to your listeners! I’m concerned about the effect of work stress on my husband’s health. He has a highly demanding job and travels a lot for work. Lately, I’ve noticed tremors/jerk-like movements while he’s asleep. He’s had some concerns about numbness to his feet, and he was told it’s likely peripheral neuropathy (his grandfather has it too). I’ve also noticed a mild but noticeable shaking in his hand, but he’s quick to dismiss it as nothing. Could these be signs of Parkinson’s disease or something else? Should he see a neurologist? And what lab tests might be good for him to get? Please advise... Thank you! Anonymous Kathryn: you speak of your morning movements a lot. Can you do a podcast on specifically what movements you do? I'm assuming they are some type of dynamic stretches and yoga poses but what are they specifically? I love your podcast. Lisa: Hi Dr. Cabral, I have fatty liver due to diabetes. I am wondering if it is safe to use your Detox protocol. I don't want to inadvertently cause more damage to my liver. Thanks so much, Lisa Tara: My mom (who is super into natural health) just referred me to your podcast. I listened to episode 858 and went to order the omega 3 and daily shakes for the daily health of me and my girls (2 and 5 years old). I am also an avid runner who has been battling plantar facitious since January. I added the Advanced Collegen Support into my basket, but thought I should ask if that’s the product you’d recommend? Per my doctor’s orders, I’ve been tapping, resting, icing, massaging, and wearing shoes with orthotics all the time (no bare feet) to help combat it, but it’s not going away (she also had me take 1 round of oral steroids, which was aweful). multiple bottles of each product, so I’d really like the discount if possible. Georgie: Hi Dr Cabral! I recently found your podcast and have been listening non-stop over the last couple of months. Thank you for sharing all your incredible knowledge - I have learned a TON. I'm hoping that you can shed some light on a random issue I've experienced... Over the last 6 months I've developed an ad-hoc reaction to alcohol. Occasionally, after 1-2 drinks, I develop a splotchy rash on my neck (and sometimes my chin/jaw) and I suddenly find it more difficult to breathe. The weird thing is that it doesn't occur every time I drink (maybe once every 5 times), and it's not tied to one type of alcohol. I've experienced this reaction after drinking red wine, vodka and tequila. Any idea what this could be? Ryan: I took a 24 hour urine organic acids test through Quest Diagnostics and was wondering if you could read the labs and give recommendations? I also had a handful of other tests done such as testosterone, DHEA, serotonin, vit d, thyroid, blood panel and a few others if those would help with the recommendations. If so, what would the cost be? Thanks for the help Ryan Chillia: Hi Dr. Cabral, Thanks so much for sharing your knowledge with us , and on many different levels. It is appreciated:) I did submit this to the Facebook support group and received an answer with really the best place to start, as far as getting certain labs done, and potentially becoming one of your private concierge clientst, but I am hoping you could take a bit of time to shed some light for the sake of my friend, who is in the thick of trying to heal herself, just to get a better understanding of what is happening with her body. Here is my best friend’s account: “In Oct 2017 I passed a fully intact round worm and was given Mebendazole by my local MD. Shortly after taking the first round of Mebandazole, I started become sick. Fatigue, heavy feeling blood, brain fog, nausea, restless feet, insomnia, dehydration ( drinking 1.5 gallons of water a day), dry cracking tongue, extreme fatigue with any cardio. With Mebendazole, you take the drug twice, but after the second round, I was still passing worms. I was confident that I still had a parasite infection, but stool tests only came back negative, so MD would not prescribe medication. I went to a private clinic out of town that specialized in parasites and was diagnosed with Round Worm and Gardia. For the next two months, I did a parasite treatment from the clinic and redoing tests showed that the parasites were gone. Unfortunately I continued to get sicker to the point I could no longer look after myself. From November to March, I was unable to walk more than a city block. I spent my time in bed and was unable to do simple things like make meals, or bring in firewood. I was aware that some foods were making me incredibly sick ( ending up in the emergency because I lost motor control after drinking a litre of kombucha ) March, I started seeing a naturopath that explained histamine intolerance as well as SIBO. With a serious change in diet, I saw instant results. I could walk a short distance and begin to look after myself. Stool test were sent to Doctor’s Data. My results came back with very low beneficial flora. I did not have any of the good flora Escherichia coli or Enteroccus spp, but I had a serious over growth of Alpha hemolytic strep, Beta Strep group B, Citronbacter freundi complex, Gamma hemolytic strep, Kluyvera ascorbate, Pseudomonas chloroaphis, Candida albicans and Candida lustitaniae With these results, I started treatment to replace my good flora and get rid of the bad flora. I have been taking once a day to kill off the bad stuff : 10 drops of grape fruit seed extract, 500mg of grape seed extract, 4 capsules of GI Microb- X (Tribulus 200mg, Magnesium caprylate 150mg, Sweet Wormwood 15mg, Bearberry 100mg, Blackwalnut 100mg, Common bearberry 50mg) Once a day for gut health : chlorophyll 5 drops, Vitamin B- Supreme ( Designs for Health Brand), GI- Revive anti inflamatory ( Designs for Health), 5000Iu Vitamin D3, 2 Tsp Omega 2 with EPA+DHA Twice a day: 25billion cfu Gut Pro Since March, my health has improved dramatically, but I feel that I am at 50 percent of my normal abilities. I cannot walk up a hill or anything cardio and I can not eat anything outside of my limited foods without a histamine flush that can slow me down or put me in bed for the afternoon. I do believe that I have always had a histamine problem. I was two months premature and then as a 11 month old, was hospitalized for Toxoplasma Gondii. I have always had food sensitivities, but boundless energy and good physical strength. I am confident that once I am better, my quality of life will probably be better than it has ever been, I am now looking for guidance on how to refine what I am doing to heal faster.” Lucy: Hi there. I am a 21 year old female and I am reaching out because I have dealt with gut & digestive issues for the last 5-10 years. 97% of things I eat immediately cause my stomach discomfort. If the food is unhealthy or full of sugar I usually feel stronger discomfort but I can even drink water too fast and feel discomfort from that as well. I did a food journal for a while and wasn't able to find any consistencies in what bothers my stomach and what doesn't. I have had allergy testing and it all came back negative. I just recently started seeing a gastroenterologist at banner hospital, she started by putting me on Pantaprazol thinking maybe the issue was inflammation in my stomach and that didn't help at all. I am scheduled to take a barium swallow test and see my gastroenterologist again next week for her to review my results. I think a naturopathic approach would be a lot more successful for me, as I would like to stay away from anti-biotics and surgeries if possible. I am looking forward to hearing back from you! Natalia: Hi. In one of the podcast it was mentioned about health/nutrition certifications that the Dr has recommended but can’t find them when i search. Could you guide me in the right direction? Also it was mentioned that he was coming up with his own certification i would like info on that please!!!! Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions! - - - Specific Show Notes & Resources: http://StephenCabral.com/960 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

Animal Radio®
Animal Radio Episode 981

Animal Radio®

Play Episode Listen Later Sep 21, 2018 87:00


Accidentally Sickening Your Pet The Senior Veterinary Toxicologist at the Pet Poison Helpline wants you to know what household toxins can fatally sicken your pets. Dr. Ahna Brutlag warns that pesticides and bait traps can kill more than bugs and mice. She also says even pet safe anti-freeze can be harmful. Listen Now Psychologist Tells Us What Pets Want From Their Owners Ever wonder how your pet sees the world? There's an entire branch of science devoted to figuring that out. Psychologist Dr. Zazie Todd has been studying the techniques guardians use to better their relationship with their pets. Listen Now Toxoplasmosis Could Actually Improve Your Life According to a new study, a mind-controlling parasite found in cat feces increases a person's likelihood of studying business and going into entrepreneurial-related careers. The parasite Toxoplasma Gondii has long been associated with impulsive behaviors leading to an increased risk of car accidents, road rage, mental illness, neuroticism, drug abuse and even suicide. Researchers believe T. Gondii exposure might push people toward higher risks and higher reward activities. The experts found that people infected with the parasite were about 1.5 times more likely to major in business and 1.7 times more likely to pursue a management and entrepreneurship major. Listen Now Animal Crackers Have Been Freed For over a century, the box of Barnum's Animals Crackers showed a caged circus boxcar with lions, elephants and other animals inside. The new box design has no cage and the animals on it are finally free, or at least not behind bars. All of the circus imagery is gone, in favor of a wildlife scene. The crackers themselves have not been changed. Hope you sleep better knowing this. Listen Now Pop Diva Sheena Easton Flashback Singer, songwriter and actress Sheena Easton provides one of the most memorable celebrity interviews on Animal Radio. Sheena is cra-cra about her kitties, no holds barred when she divulges how she spoils her cats and dogs. Listen Now

Meet the Microbiologist
086: Toxoplasma gondii and neuro-invasive disease with Anita Koshy

Meet the Microbiologist

Play Episode Listen Later Jul 12, 2018 35:38


How is Toxoplasma gondii, a protozoan that causes neuro-invasive disease, transmitted as a foodborne pathogen? Why are cats important in transmitting Toxoplasma infection? Anita Koshy answer these questions and talks about her research on the latest Meet the Microbiologist. Julie’s Biggest Takeaways: The primary host for T. gondii is cats, in which the protozoan can undergo sexual reproduction. Why cats? No one knows, in part because there isn’t a good in vitro system to study cat epithelial cell interactions with T. gondii. Most warm-blooded animals, including birds, can be infected with Toxoplasma. Intermediate hosts can pass Toxoplasma from one to another if one eat these tissue cysts, explaining why Toxoplasma can be a foodborne pathogen. In healthy individuals, the immune response clears most fast-growing cells (tachyzoites) but some protozoans convert to a slow-growing cell form (bradyzoites). In people, these bradyzoites form cysts predominantly in the brain, the heart and the skeletal muscle. Some serological studies suggest a tie between Toxoplasma infection and brain disorders, but these are less definitive than causative studies in mice. Populations with high Toxoplasma or low Toxoplasma prevalence don’t see a correlative incidence of disorders such as schizophrenia or Alzheimer’s disease. Featured Quotes: “When we talk about neuroinfectious diseases, we’re talking about the diseases that cause symptoms. Those that can get into the central nervous system and those that cause symptomatic disease are the same.” “A parasite is sitting there dormant or maybe reactivating every so often and the immune system comes in and deals with that reactivation. But when you lack an immune system, all of a sudden when that parasite reactivates, there is no longer this immune system that will come in and clear it out.” “What we don’t know is whether reactivation occurs preferentially in the brain. There is evidence from HIV patients of inflammation of the heart or inflammation of the skeletal tissue - but those weren’t the symptoms that presented, which were of the brain. Did reactivation happen in the brain, or did it occur elsewhere and the parasite was able to travel to the brain and there’s no longer an immune system to clear it out?” Links for this Episode: Koshy Lab Site Sea Otter Infection with Toxoplasma Rats Infected with T. gondii Lose Their Aversion to Cat Urine HOM Tidbit: The History of Toxoplasma gondii Bill Hutchinson obituary  

Microbe Magazine Podcast
MMP #16: Insights into Toxoplasma gondii parasites

Microbe Magazine Podcast

Play Episode Listen Later Sep 14, 2016 37:41


Host: Jeff Fox with special guest, Emma Wilson. Emma H. Wilson of the University of California, Riverside, talks with Jeff Fox about efforts, with her collaborators to determine more precisely how Toxoplasma gondii parasites disrupt the mammalian brain—in this case, the brains of mice. This same parasite infects about one-third of the human population, but is held in check by the immune system unless those host defense mechanisms become impaired. Wilson and her collaborators find that these parasites interfere with the cycling of the neurotransmitter glutamate within the central nervous system, blocking its uptake by astrocytes, widely distributed cells within brains that are intertwine with and thus work very closely with neurons, which are the main cells for transmitting nerve impulses throughout the central nervous system.  Some damaging effects of the parasites can be reversed by treating the mice with a drug—in this case, it happens to be an antibacterial drug but here acts by a separate mechanism-- that helps to restore the glutamate transport protein in astrocytes. In this way, it partly corrects that glutamate imbalance within the brain. This story was featured in the August 2016 issue of Microbe Magazine. Subscribe to MMP (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Send your microbiology questions and comments (email or audio file) to jfox@asmusa.org Tweet me your questions about this episode or just to say hi!

Mi Gato Dinamita
Mi Gato Dinamita #25

Mi Gato Dinamita

Play Episode Listen Later Sep 23, 2015 57:00


Bienvenidos al vigésimo quinto episodio de Mi Gato Dinamita, el podcast favorito de las luminarias musicales. Duración total: 57:00.00:01-01:39 - Música: “Free As A Cat”, version libérrima de “Free As A Bird” de Lennon/The Beatles por Guille & Susanette.01:40-09:53 - Susanette y Guille dan la bienvenida a nuestros oyentes, repasando unas estrofas más de la canción que dio inicio al Podcast. Susanette habla de su exilio voluntario en Tucumán en casa de @super_pancha, en donde se dedica a cocinar y dejar que sus gatos destrocen la morada de su anfitriona.09:54-23:27 - Nos visita en el estudio una verdadera leyenda de la música argentina: Charly García. Nuestro invitado de lujo nos honra con un popurrí de sus canciones (o de los pedacitos que recuerda), en ocasiones acompañado por la dulce voz de Susanette.23:28-28:47 - Entintado habla de parásitos, toxoplasmosis y zombies.28:48-31:45 - Música: "Insane In The Brain", por Cypress Hill.31:46-41:28 - Susanette, Guille y Charly repasan temas varios: gatos, música, Donald Trump, las visitas de Guille, su infancia, Elton John y la comida en lo de Palito Ortega.41:29-45:43 - Música: "Yendo De La Cama Al Living", por Charly García.45:44-52:08 - Saludamos a todos nuestros oyentes, planeando un festejo itinerante por todo el país para cuando lleguemos al millar de seguidores en nuestra cuenta de Twitter.52:09-57:00 - Música: "So Lonely", por The Police.Ilustramos este episodio, como corresponde, con algunas imágenes alusivas: Charly García; las perritas de @super_pancha; una tarta de salame; un café batido; un bar de barrio con wi-fi; y el Toxoplasma Gondii. Como siempre, podés disfrutar de este episodio online con el reproductor de acá arriba, bajártelo en formato .mp3 haciendo clic en donde dice "Download" o escucharlo en SoundCloud. Si querés suscribirte a este podcast con tu aplicación favorita, buscanos en iTunes o usá nuestro feed RSS.

Science On Top
SoT 163: The 2014 Ig Nobel Prizes

Science On Top

Play Episode Listen Later Oct 8, 2014 63:40


The Ig Nobel Prizes honour achievements that first make us laugh, then make us think. We take a look at this year's winners: from banana peels to people dressed as polar bears! PHYSICS PRIZEA team from Japan for measuring the amount of friction between a shoe and a banana skin, and between a banana skin and the floor, when a person steps on a banana skin that's on the floor.Banana peel slipperiness wins IgNobel prize in physics NEUROSCIENCE PRIZEScientists from China and Canada for trying to understand what happens in the brains of people who see the face of Jesus in a piece of toast.University Of Toronto Researchers Find ‘Seeing Jesus In Toast' Phenomenon Perfectly Normal PSYCHOLOGY PRIZEA team from Australia, the UK and the US for amassing evidence that people who habitually stay up late are, on average, more self-admiring, more manipulative, and more psychopathic than people who habitually arise early in the morning.THE DARK TRIAD: People Who Love The Night Have Psychopathic Traits PUBLIC HEALTH PRIZEA number of scientists from the Czech Republic, Japan, the USA and India for investigating whether it is mentally hazardous for a human being to own a cat. Turns out it can be, if you get infected with our old friend Toxoplasma Gondii.Parasite makes men dumb, women sexy BIOLOGY PRIZEA team from the Czech Republic, Germany and Zambia for carefully documenting that when dogs defecate and urinate, they prefer to align their body axis with Earth's north-south geomagnetic field lines.Dogs align their bodies along a North-South axis when they poopDo Dogs Line Themselves Up With the Earth's Magnetic Field to Poop? ART PRIZEThree scientists from Italy, for measuring the relative pain people suffer while looking at an ugly painting, rather than a pretty painting, while being shot [in the hand] by a powerful laser beam.ITALY: Beautiful art eases pain ECONOMICS PRIZEISTAT — the Italian government's National Institute of Statistics, for proudly taking the lead in fulfilling the European Union mandate for each country to increase the official size of its national economy by including revenues from prostitution, illegal drug sales, smuggling, and all other unlawful financial transactions between willing participants.In Italy, prostitutes and illegal drugs could shrink the deficit MEDICINE PRIZEA team from the USA and India for treating "uncontrollable" nosebleeds, using the method of nasal-packing-with-strips-of-cured-pork.The Bacon Tampon: Doctors Find Salt Pork Stops Nosebleeds ARCTIC SCIENCE PRIZEScientists from Norway, Germany, USA and Canada for testing how reindeer react to seeing humans who are disguised as polar bears.Svalbard Reindeer: Thriving Again on the Tundra NUTRITION PRIZEScientists in Spain for their study titled "Characterization of Lactic Acid Bacteria Isolated from Infant Faeces as Potential Probiotic Starter Cultures for Fermented Sausages."Pooperoni? Baby-Poop Bacteria Help Make Healthy Sausages

60-Second Health
Use Care with Cat Caca

60-Second Health

Play Episode Listen Later Jul 18, 2013 1:19


Our feline friends might be carrying hazardous organisms in their waste, so be careful when scooping that poop. Katherine Harmon reports

Animal Radio®
Animal Radio® Episode 659

Animal Radio®

Play Episode Listen Later Jul 20, 2012 110:50


Joy Behar Guests She has strong opinions, especially when it comes to letting her pets in bed with her. The View's Joy Behar is our special guest and she tells all about her furry family. She's a talented comedian and writer, and she couldn't care less what trainers say about sleeping with your dog. She loves it! Recalled Food Contains Plastic Mars Petcare has announced a recall of some varieties of Pedigree canned dog food because of a potential choking risk. The recall affects only weight management varieties, was issued after the discovery of small pieces of blue plastic that entered the food during the production process. Kitty Litter Suicides A parasite commonly found in kitty litter boxes could increase a person's risk for suicide. A new study shows the Toxoplasma Gondii parasite causes changes in the brain of an infected person that make them more likely to attempt or commit suicide. Blankets of Love Eileen Smulson is the Top Dog and "Blankets of Love," a non-profit that collects items needed to make homeless animals more comfortable and ultimately more adoptable. Losing Weight While Walking Your Dog Janine Lechuga was overweight until she invented a multi-tasking leash that counts your calories burned when you walk. She's lost 50 pounds and has created a great new pet product too. More this week

This Week in Parasitism
TWiP #12 - Toxoplasma gondii

This Week in Parasitism

Play Episode Listen Later Jun 17, 2010 97:39


Vincent and Dickson introduce the obligate intracellular protozoan Toxoplasma gondii, one of the most successful parasites on earth. Host links: Vincent Racaniello and Dickson Despommier Links for this episode: Global clinical burden of malaria (PLoS Medicine) T. gondii sporulated oocysts (jpg) T. gondii tachyzoites in parasitophorous vacuole (jpg) T. gondii life cycle (jpg) Insect bioterrorism conference (thanks, Don!) Parasite of the Day (thanks, Douglas!) World Science Festival Letters read on TWiP 12