Podcasts about ny october

BUFFALO, NY- October 31, 2024 – A new #research paper was #published as the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 20, entitled, “Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.” This paper summarizes recent advances in healthspan biotechnology discussed at the 2023 Aging Research and Drug Discovery Meeting (ARDD), where leading experts reviewed breakthroughs in artificial intelligence (AI), biomarkers, aging clocks, geroscience, and clinical trials that support healthier, longer lives. The authors present a comprehensive view of how these technologies are shaping research and industry approaches to aging, focusing on targeting aging itself to reduce multiple age-related diseases and extend the healthy years of life. With people living longer, addressing age-related health issues is more critical than ever. Traditional healthcare often treats age-related diseases individually, overlooking aging as a core issue. Longevity biotechnology seeks to change this by combining AI with biomarker analysis to detect early signs of aging, enabling targeted interventions that not only delay disease but also promote longer, healthier lives. Led by corresponding authors Yu-Xuan Lyu from Southern University of Science and Technology Shenzhen; Alex Zhavoronkov from Insilico Medicine AI Limited, Masdar City, Abu Dhabi; Morten Scheibye-Knudsen and Daniela Bakula from the Center for Healthy Aging, University of Copenhagen, this research synthesizes the potential of AI to identify precise biomarkers of aging, supporting the development of "aging clocks"—tools that use biological data to estimate a person's biological age and health risks. These tools help clinicians tailor prevention and treatment to individual needs. Additionally, AI speeds up the discovery of drugs that target primary aging drivers, such as cellular damage and decreased cellular energy, offering the potential to slow, prevent, or even reverse certain effects of aging and enhance quality of life. “The fusion of AI with biomarker research has markedly revolutionized the way biomarkers are identified and validated in the field of ageing.” This approach not only promises to slow, prevent, or even reverse certain effects of aging but also emphasizes the potential for AI-driven methods to extend healthspans. In conclusion, the authors emphasize the need for continued investment in AI-driven therapies and biomarker research, which hold the potential to redefine aging care and improve health outcomes as people grow older. DOI - https://doi.org/10.18632/aging.206135 Corresponding Authors - Yu-Xuan Lyu - lvyx@sustech.edu.cn, Alex Zhavoronkov - alex@insilico.com, Morten Scheibye-Knudsen - mscheibye@sund.ku.dk, and Daniela Bakula - bakula@sund.ku.dk Video short - https://www.youtube.com/watch?v=Hpfe5WJ5g7I Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206135 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, biotechnology, artificial intelligence, healthy longevity About Aging-US The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 30, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on October 11, 2024, entitled “Initiation of tumor dormancy by the lymphovascular embolus.” Researchers Yin Ye, Justin Wang, Michael G. Izban, Billy R. Ballard, and Sanford H. Barsky from Meharry Medical College in Nashville, TN, and Scripps Mercy Hospital in San Diego, CA, uncovered critical mechanisms that lead to tumor dormancy in breast cancer. This study sheds light on how certain cancer cells can remain dormant for years before potentially reawakening as metastatic tumors. Using breast cancer patient-derived organoids and tumor samples, the research team discovered that tumor dormancy in breast cancer can be triggered by specific signaling changes within small cell clusters, called tumor emboli, which detach from the primary tumor and travel through the bloodstream. These emboli can remain inactive, sometimes for years, before reawakening in other parts of the body. Key changes include reduced activity of mTOR, a metabolic regulator, and structural shifts in E-cadherin, a molecule involved in cell adhesion. This study also suggests these changes are regulated by the PI3K pathway and occur within the unique three-dimensional structure of tumor spheroids, shedding light on the interactions within dormant cell clusters. As a conclusion, this work not only identifies mTOR and E-cadherin as key components in maintaining dormancy but also offers a promising roadmap for future therapies. By targeting these pathways, there may be potential to keep cancer cells in a dormant state, reducing the risk of late-stage recurrence and improving patient outcomes. DOI - https://doi.org/10.18632/oncotarget.28658 Correspondence to - Sanford H. Barsky - sbarsky@mmc.edu Video short - https://www.youtube.com/watch?v=z6ex7Yl8r5Q Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28658 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, dormancy, lymphovascular embolus, mTOR, E-cadherin proteolysis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 29, 2024 – A new #casereport was #published in Oncotarget's Volume 15 on October 11, 2024, entitled “Complete response to encorafenib plus binimetinib in a BRAF V600E-mutant metastasic malignant glomus tumor.” As highlighted in the abstract, glomus tumors (GT) are rare mesenchymal neoplasms originating in dermal arteriovenous structures involved in thermoregulation. While generally benign, some can exhibit malignant features, leading to aggressive behavior, metastasis, and limited response to standard chemotherapy. The identification of the BRAF V600E mutation in certain malignant GT cases offers a promising therapeutic target. In their paper, researchers Marta Arregui, Antonio Calles, María del Mar Galera, Ana Gutiérrez, Carlos López-Jiménez, Carolina Agra, Adriana Fernández, Natalia Gutiérrez, María de Toro and Rosa Álvarez from Gregorio Marañón University Hospital and Fundación Jiménez Díaz University Hospital in Madrid, Spain, document a remarkable clinical and metabolic response in a case of metastatic BRAF V600E-mutated glomangiosarcoma treated with the combination of encorafenib and binimetinib. They report on a 45-year-old male patient with stage IV malignant GT carrying a BRAF V600E mutation, who was treated systemically with encorafenib and binimetinib. This approach led to a swift clinical and radiological improvement. “To our knowledge, our patient represents the first reported case of a metastatic malignant GT successfully treated with BRAF and MEK inhibitors, achieving a long-lasting complete morpho-metabolic response.” DOI - https://doi.org/10.18632/oncotarget.28654 Correspondence to - Carlos López-Jiménez - clopezjimenez@atbsarc.org Video short - https://www.youtube.com/watch?v=xjbj3Iu16P4 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28654 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, malignant glomus tumor, glomangiosarcoma, BRAF V600E, agnostic treatment, targeted therapy About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 29, 2024 – A new #editorial was #published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 19 on October 14, 2024, entitled “Integrating cardiovascular risk biomarkers in the context of inflammaging.” Cardiovascular diseases (CVD) remain the leading cause of death worldwide, accounting for nearly one-third of all global mortalities. Risk assessment for CVD has traditionally focused on well-known factors linked to atherosclerosis, including demographics, lifestyle choices like smoking and physical activity, and conditions such as diabetes, hypertension, and obesity. Biomarkers, such as non-HDL cholesterol, have also played a key role in identifying those at risk. However, significant residual cardiovascular risk persists despite managing these established risk factors, suggesting additional, unaddressed contributors to cardiovascular health. In their paper, researchers Jacopo Sabbatinelli, Matilde Sbriscia, Fabiola Olivieri, and Angelica Giuliani from Università Politecnica delle Marche and IRCCS INRCA in Ancona, Italy, explore how integrating specific cardiovascular biomarkers could help assess this residual inflammatory risk, particularly in the context of aging-related inflammation, or “inflammaging.” The biomarkers investigated—high-sensitivity C-reactive protein (hs-CRP), high-sensitivity cardiac troponin (hs-cTn), and natriuretic peptides—serve as valuable indicators of both inflammatory burden and early cardiovascular risk. In conclusion, the authors demonstrate that combining markers of chronic inflammation with cardiac health indicators offers a more complete understanding of cardiovascular risk and reveals the impact of aging-related inflammation, or “inflammaging,” on heart health. Researchers suggest that this approach opens new avenues for targeted interventions in aging populations. DOI - https://doi.org/10.18632/aging.206136 Corresponding author - Jacopo Sabbatinelli - j.sabbatinelli@staff.univpm.it Video short - https://www.youtube.com/watch?v=yJJXbwHj6hs Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206136 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cardiovascular disease, inflammaging, cardiac biomarkers, residual inflammatory risk About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Qool DJ Marv Live at Dumbo House Brooklyn NY - October 27 2024 - Mauve ---     https://www.sohohouse.com/en-us/houses/dumbo-house     +    Artwork: https://www.artbyycolemanburney.com/      ---    https://www.youtube.com/channel/UC5gQLsodBsCys1_3Zbm83vg        https://podcasts.apple.com/gb/podcast/qool-dj-marv-aural-memoirs-and-buttamilk-archives/id269880758        https://music.apple.com/us/artist/qool-dj-marv/1558418894        https://www.instagram.com/qooldjmarv/        https://qooldjmarv.bandcamp.com/album/sound-paths-v-1        https://tidal.com/browse/artist/23883666        https://www.mixcloud.com/qooldjmarv/        https://open.spotify.com/artist/48vhJ2d1hVaFHf6gqXeTm0?si=fWO0N456QeWRMWLUtqe4Yg        https://twitter.com/qooldjmarv        https://www.threads.net/@qooldjmarv        https://www.facebook.com/MarvJColeman/        https://soundcloud.com/qooldjmarv    

BUFFALO, NY- October 24, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 3, 2024, entitled “A new model and precious tool to study molecular mechanisms of macrophage aging.” As highlighted in the abstract, the accumulation of senescent cells, marked by a senescence-associated secretory phenotype (SASP), plays a role in chronic inflammation and age-related diseases (ARD). During aging, macrophages can develop a senescent-like phenotype with altered functions, promoting the buildup of senescent cells. In the context of aging and ARD, controlling the resolution of inflammation and preventing chronic inflammation—particularly by targeting macrophages—should be a priority. In their paper, researchers Rémy Smith, Kévin Bassand, Ashok Dussol, Christophe Piesse, Eric Duplus, and Khadija El Hadri from Sorbonne Université in Paris and Université Sorbonne Paris Nord in Bobigny, France, developed an in vitro model of murine peritoneal macrophage aging. Using this model, they demonstrated that chronic treatment with CB3, a thioredoxin-1 mimetic anti-inflammatory peptide, completely prevents the increase of p21CIP1 and allows day 14 macrophages to maintain their proliferative activity. "We describe a new model of macrophage aging with a senescence-like phenotype associated with inflammatory, metabolic and functional perturbations.” DOI - https://doi.org/10.18632/aging.206124 Corresponding authors - Eric Duplus - eric.duplus@sorbonne-universite.fr, and Khadija El Hadri - khadija.zegouagh@sorbonne-universite.fr Video short - https://www.youtube.com/watch?v=LfN78LR-CYU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206124 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, macrophage, inflammation, senescence, thioredoxin-1 mimetic peptide About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 23, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on October 11, 2024, entitled, “Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment.” As highlighted in the paper, Acute Myeloid Leukemia (AML) is a complex and diverse disease caused by multiple mutations in genes that regulate transcription and growth. These mutations lead to extensive rewiring of the gene regulatory network (GRN), which alters the identity of hematopoietic stem and progenitor cells, ultimately blocking normal myeloid differentiation. A key feature of AML is the presence of mutations in growth factor receptor and signaling genes, such as FLT3, KIT, and RAS. Notably, FLT3 is one of the most commonly mutated genes in AML, with around 25% of cases showing an internal tandem duplication (ITD) that causes the receptor to remain constantly active. In their paper, researchers Constanze Bonifer and Peter N. Cockerill from the Institute of Cancer and Genomic Sciences at the University of Birmingham, UK, and the Murdoch Children's Research Institute, Royal Children's Hospital in Melbourne, Australia, discuss recent publications from their group addressing this issue through a multi-omics study. The authors investigated how gene regulatory networks (GRNs) in FLT3-ITD patients were rewired compared to normal cells and in response to FLT3 inhibitor treatment. Several key findings stood out, including: 1) Mapping of open chromatin regions revealed that patients initially responsive to FLT3 inhibition showed significant rewiring of their GRNs, forming new connections between transcription factors (TFs) and target genes, while non-responsive patients did not; 2) Chromatin immunoprecipitation (ChIP) experiments showed that drug treatment led to the loss of binding of RUNX1, the master regulator of hematopoiesis, and the MAP-Kinase (MAPK)-inducible TF AP-1; 3) Disruption of AP-1 binding via a dominant-negative version of the TF (dnFOS) also abolished RUNX1 binding at hundreds of sites, indicating that RUNX1 binding is AP-1 dependent; and 4) Inhibition of both AP-1 and RUNX1 led to a pronounced cell cycle block. “In summary, drugs that target individual signalling pathways in AML often fail to stop proliferation malignant growth, due to the wide variety, redundancy and cross talk between multiple pathways regulating and differentiation.” DOI - https://doi.org/10.18632/oncotarget.28662 Correspondence to - Constanze Bonifer - constanze.bonifer@mcri.edu.au Video short - https://www.youtube.com/watch?v=5c_uT6aE36A Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28662 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, acute myeloid leukemia, gene regulatory networks, aberrant growth factor signaling, transcription, RUNX1/AP-1 axis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

BUFFALO, NY- October 22, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on September 26, 2024, entitled, “Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model.” Pelvic organ prolapse is a common condition among women in the U.S., with a 13% estimated risk of requiring surgery by age 80. Senolytic agents like dasatinib and quercetin (D+Q) target age-related cellular senescence and reduce senescent cell activity in various disease processes. In their paper, researchers Erryn Tappy, Haolin Shi, Jessica Pruszynski, and Maria Florian-Rodriguez from the University of Texas Southwestern Medical Center, Department of Obstetrics and Gynecology in Dallas, utilized a mouse model of pelvic organ prolapse, Fibulin-5 knockout (Fbln-5-/-) mice, to assess the ability of D+Q to prevent development of prolapse. The D+Q injections administered did not result in significant differences in prolapse development but did reduce cellular senescence markers in Fbln-5-/- mice. This suggests senolytic agents may help mitigate the role of cellular senescence in tissue dysfunction associated with prolapse. The researchers suggest that further studies are needed to determine optimal timing, dosage, and delivery of senolytics for prolapse prevention. "This study represents one of the first to evaluate the impact of senolytic agents D+Q on the clinical development of pelvic organ prolapse and expression of proteins associated with cellular senescence in a mouse model.” DOI - https://doi.org/10.18632/aging.206120 Corresponding author - Maria Florian-Rodriguez - Maria.Florian-Rodriguez@UTSouthwestern.edu Video short - https://www.youtube.com/watch?v=kTQfjhubx_4 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206120 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, pelvic organ prolapse, cellular senescence, senolytic agents, animal model About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Qool DJ Marv Live on the deck at Dumbo House Brooklyn NY - October 20 2024 - ...Before it Gets Cold --- https://www.sohohouse.com/en-us/houses/dumbo-house + Image: https://www.coreybarksdale.com/index.html ---     https://www.youtube.com/channel/UC5gQLsodBsCys1_3Zbm83vg        https://podcasts.apple.com/gb/podcast/qool-dj-marv-aural-memoirs-and-buttamilk-archives/id269880758        https://music.apple.com/us/artist/qool-dj-marv/1558418894        https://www.instagram.com/qooldjmarv/        https://qooldjmarv.bandcamp.com/album/sound-paths-v-1        https://tidal.com/browse/artist/23883666        https://www.mixcloud.com/qooldjmarv/        https://open.spotify.com/artist/48vhJ2d1hVaFHf6gqXeTm0?si=fWO0N456QeWRMWLUtqe4Yg        https://twitter.com/qooldjmarv        https://www.threads.net/@qooldjmarv        https://www.facebook.com/MarvJColeman/        https://soundcloud.com/qooldjmarv    

BUFFALO, NY- October 21, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.” As highlighted in the abstract, monoclonal antibody therapies for cancer have shown extraordinary clinical success in recent years. However, these strategies are primarily limited to targeting specific cell surface antigens, despite many disease targets being located intracellularly. In their paper, researchers Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, and Peter M. Glazer from the Departments of Therapeutic Radiology and Genetics at Yale University School of Medicine, Gennao Bio, and the Department of Molecular Biophysics and Biochemistry at Yale University report on the humanization of the full-length, nucleic acid-binding monoclonal lupus-derived autoantibody 3E10, which exhibits a novel mechanism for cell penetration and tumor-specific targeting. The authors compare humanized variants of 3E10 and demonstrate that cell uptake relies on the nucleoside transporter ENT2. They also find that faster cell uptake and superior in vivo tumor targeting are associated with higher affinity nucleic acid binding. “We show that one human variant retains the ability of the parental 3E10 to bind RAD51, serving as a synthetically lethal inhibitor of homology-directed repair in vitro.” DOI - https://doi.org/10.18632/oncotarget.28651 Correspondence to - Peter M. Glazer - peter.glazer@yale.edu Video short - https://www.youtube.com/watch?v=sTHjJ0Qq0YQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28651 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 17, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on September 18, 2024, entitled, “Fibroblast growth factor 21 inversely correlates with survival in elderly population – the results of the Polsenior2 study.” As noted in the abstract, fibroblast growth factor 21 (FGF21) is a liver-secreted hormone involved in regulating lipid, glucose, and energy metabolism. Its serum concentration increases with age and is elevated in various diseases. FGF21 is currently being investigated for its potential as a biomarker and therapeutic target. In their paper, Polish researchers Gabriela Handzlik, Aleksander J. Owczarek, Andrzej Więcek, Małgorzata Mossakowska, Tomasz Zdrojewski, Anna Chudek, Magdalena Olszanecka-Glinianowicz, and Jerzy Chudek from the Medical University of Silesia in Katowice, the International Institute of Molecular and Cell Biology in Warsaw, and the Medical University of Gdansk aimed to assess the prognostic value of FGF21 in an older, population-based cohort from the PolSenior2 study. The researchers report that in a sub-analysis of 3,512 individuals aged 60 and older, stratified into tertiles based on FGF21 levels, the survival estimate was worse in participants with middle and high FGF21 levels compared to those in the lowest tertile. These findings were supported by univariable Cox regression analysis, where participants in the middle and high FGF21 tertiles, after adjusting for age, had a 1.43-fold (HR 1.31; 95% CI, 1.05–1.62) and 2.56-fold (HR 1.94; 95% CI, 1.59–2.37) increased risk of mortality, respectively, compared to the lowest tertile. In multivariable Cox regression analysis, the highest FGF21 levels were independently associated with increased mortality (HR 1.53; 95% CI, 1.22–1.92), regardless of co-morbidities and blood parameters. "These results indicate that higher serum FGF21 concentration is an independent predictor of all-cause mortality in the general population of older adults.” DOI - https://doi.org/10.18632/aging.206114 Corresponding author - Gabriela Handzlik - ghandzlik@sum.edu.pl Video short - https://www.youtube.com/watch?v=QkPrI68nbLE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206114 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, fibroblast growth factor 21, survival, population-based study, longevity About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 16, 2024 – A new #review was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.” As highlighted in the abstract of this paper, "tumor suppressor" describes a diverse set of genes typically involved in suppressing metastasis, but which can lead to tumorigenesis when loss-of-function mutations occur. Despite the varied structures and functions of tumor suppressor proteins, many share a common regulatory mechanism—they are "clients" of molecular chaperones, and they rely on an intracellular network of chaperones and co-chaperones to maintain their stability. Mutations in tumor suppressors that disrupt proper chaperoning prevent cells from maintaining sufficient protein levels for normal physiological function. In their review, researchers Jennifer A. Heritz, Sarah J. Backe, and Mehdi Mollapour from SUNY Upstate Medical University and New York VA Health Care in Syracuse, New York, discuss the role of molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. They also detail the contributions of co-chaperones prefoldin, HOP, Aha1, p23, FNIP1/2, and Tsc1, as well as the chaperonin TRiC, to tumor suppressor stability. “Overall, it is clear that oncogenesis can result from the dysregulation of tumor suppressor stabilization by chaperones.” DOI - https://doi.org/10.18632/oncotarget.28653 Correspondence to - Mehdi Mollapour - mollapom@upstate.edu Video short - https://www.youtube.com/watch?v=V5OFjeqaH3A Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28653 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, “A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice.” As noted in the abstract, bone mass declines with age, and the anabolic effects of skeletal loading decrease. While much research has focused on gene transcription, how bone ages and loses its mechanoresponsiveness at the protein level remains unclear. In their paper, researchers Christopher J. Chermside-Scabbo, John T. Shuster, Petra Erdmann-Gilmore, Eric Tycksen, Qiang Zhang, R. Reid Townsend, and Matthew J. Silva from Washington University School of Medicine and Washington University in St. Louis, Missouri, describe how they developed a novel proteomics approach and conducted paired mass spectrometry and RNA-seq analyses on tibias from young-adult (5-month) and old (22-month) mice. The researchers report the first correlation estimate between the bone proteome and transcriptome (Spearman ρ = 0.40). While this is consistent with findings from other tissues, it suggests that only a relatively low amount of variation in protein levels is explained by variation in transcript levels. Of the 71 shared targets that differed with age, eight were associated with bone mineral density in previous GWAS, including the understudied targets Asrgl1 and Timp2. Using complementary RNA in situ hybridization, the researchers confirmed that Asrgl1 and Timp2 showed reduced expression in osteoblasts/osteocytes in aged bones. Additionally, they found evidence of reduced TGF-beta signaling with aging, particularly Tgfb2. The researchers also identified proteomic changes following mechanical loading, noting that at the protein level, bone differed more with age than with loading, and aged bone exhibited fewer loading-induced changes. "Overall, our findings underscore the need for complementary protein-level assays in skeletal biology research.” DOI - https://doi.org/10.18632/aging.206131 Corresponding author - Christopher J. Chermside-Scabbo - ccherms@wustl.edu Video short - https://www.youtube.com/watch?v=xm6o7gWH8p4 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206131 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, bone, mechanical loading, proteomics, RNA-seq/transcriptomics About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 11, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Transplant or no transplant for TP53 mutated AML.” As highlighted in this editorial, TP53 mutations (mut) occur in 10–15% of acute myeloid leukemia (AML) cases, commonly associated with therapy-related AML (t-AML) and complex cytogenetics (CG). TP53-mut AML is inherently resistant to conventional chemotherapies and continues to show a poor prognosis, even with venetoclax-based therapies. Allogeneic hematopoietic stem cell transplant (allo-HCT) remains a potential curative option, though only 10–15% of patients receive it. In a recent study, allo-HCT was the only variable significantly improving survival, despite only 16% of patients successfully bridging to it. In their editorial, researchers Talha Badar, Moazzam Shahzad, Ehab Atallah, Mark R. Litzow, and Mohamed A. Kharfan-Dabaja from the Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapy Program at Mayo Clinic (Jacksonville, Florida) evaluated the outcomes of TP53-mutated AML patients based on data from the Consortium of Myeloid Malignancies and Neoplastic Diseases (COMMAND). The study found a “dismal” survival rate of 8.5 months, with no significant difference among treatment types, and allo-HCT was the only variable associated with improved survival. The authors also report on the “better long-term outcomes” when allo-HCT was performed during Complete Remission 1 (CR1) in previous observations. They acknowledge the limitations of their retrospective analysis, including selection bias, data heterogeneity from participating institutions, and the lack of complete molecular data prior to allo-HCT that might have influenced the results. Nevertheless, the findings are encouraging and suggest that allo-HCT improves long-term outcomes in this poor prognostic disease, where effective therapies remain limited. “In summary, this study reported improved survival when allo-HTC was performed in CR1 versus after later lines of therapy.” DOI - https://doi.org/10.18632/oncotarget.28652 Correspondence to - Talha Badar - badar.talha@mayo.edu Video short - https://www.youtube.com/watch?v=OQue9gbqsxE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28652 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, AML, TP53 mutation, allogeneic stem cell transplant About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 9, 2024 – A new #review was #published in Oncotarget's Volume 15 on September 30, 2024, entitled, “Zika virus and brain cancer: Can Zika be an effective treatment for brain cancer? A systematic review.” As highlighted in the introduction of this review, many studies have identified oncolytic viruses as a promising new class of therapeutic agents for central nervous system (CNS) tumors, particularly glioblastomas (GBM). Zika virus (ZIKV) proteins, specifically targeting certain stem cells, have shown promising results in both in vitro and animal model studies. In their review, researchers Mateus Gonçalves de Sena Barbosa, Beatriz Rodrigues Messias, Rafael Trindade Tatit, Maycon Cristian Gomes de Paula, Valdecir Boeno Spenazato Júnior, Maria Gabriella Borges Braga, Caio Vinícius Marcolino Santos, Luiza D'Ottaviano Cobos, Vinícius Otávio da Silva, Eberval Gadelha Figueiredo, Nicollas Nunes Rabelo, and Bipin Chaurasia from Atenas University Center, Passos; University of Israelita de Ciências da Saúde Albert Einstein; University of Sapucaí Valley; Atenas University Center, Sete Lagoas; Nove de Julho University, Campus Vergueiro; José do Rosário Vellano University, Alfenas; School of Medicine-University of São Paulo (FMUSP), Hospital das Clínicas/FMUSP; and Neurosurgery Clinic in Birgunj, evaluated the efficacy and safety of using ZIKV for treating CNS tumors. Data from in vivo studies were extracted and assessed for bias using the Robins-I tool, evaluating factors such as selection, performance, detection, attrition, and reporting bias. The 14 studies demonstrated that ZIKV reduced cell viability, inhibited the growth and proliferation of glioma stem cells (GSCs), and decreased Bcl2 expression, potentially enhancing chemotherapy and radiotherapy effects. ZIKV caused cytopathic effects, induced tumor cell damage, showed oncolytic properties, and selectively killed GSCs safely. This ultimately led to significant tumor remission and improved long-term survival through an enhanced T-cell response. “Although current evidence suggests ZIKV as a promising treatment for CNS tumors and may improve survival when combined with surgery and radiotherapy.” DOI - https://doi.org/10.18632/oncotarget.28647 Correspondence to - Bipin Chaurasia - trozexa@gmail.com Video short - https://www.youtube.com/watch?v=JINORGdqAO4 Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28647 Subscribe for free publication alerts from Oncotarget: https://www.oncotarget.com/subscribe/ Keywords - cancer, Zika, neurotropism, glioblastoma, glioma, brain tumor About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 8, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 18 on September 18, 2024, entitled, “Determinants of cerebral blood flow and arterial transit time in healthy older adults.” This research paper highlights that brain health deteriorates with age, particularly in terms of cerebral blood flow (CBF) and arterial transit time (ATT), key markers of brain vascular health. This decline can impair cognitive function and limit independence in later life—an issue that will affect many as the global population continues to age rapidly. In their paper, researchers Jack Feron, Katrien Segaert, Foyzul Rahman, Sindre H. Fosstveit, Kelsey E. Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, and Samuel J. E. Lucas from the University of Birmingham, University of Agder, and University of Nottingham aimed to identify modifiable determinants of CBF and ATT in healthy older adults (n = 78, aged 60–81 years). They also investigated the relationship between CBF, ATT, and cognitive function in older adults. The researchers hypothesized that markers of superior general health—such as higher cardiorespiratory fitness, handgrip strength, and grey matter volume, or lower age, BMI, and blood pressure—would be associated with greater CBF and shorter ATT. Results from multiple linear regressions revealed that a higher BMI was associated with lower global cerebral blood flow (CBF) (β = −0.35, P = 0.008) and longer global arterial transit time (ATT) (β = 0.30, P = 0.017). Additionally, global ATT increased with age (β = 0.43, P = 0.004), while higher cardiorespiratory fitness was linked to longer ATT in the parietal (β = 0.44, P = 0.004) and occipital (β = 0.45, P = 0.003) regions. However, neither global nor regional CBF or ATT were associated with processing speed, working memory, or attention. “In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health.” DOI - https://doi.org/10.18632/aging.206112 Corresponding author - Jack Feron - j.feron@bham.ac.uk Video short - https://www.youtube.com/watch?v=QpS4kK273os Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206112 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Your favorite podcast is back after a summer hiatus! Small business coach & retreat leader, Desha Peacock, and holistic interior designer, Christine Martin kick start season 2 with reflections, intentions, and a very special invitation for you.  Be part of the magic unfolding! Shownotes 0:00   Intro 0:42  The Good Abode 1:48 Kicking off Season 2: we're back! 2:32 Desha's summer reflection; taking a marketing break & the hospitality dream 5:08 More than manifestation 5:48 The expansion of She DESIGNS 8:13 The thread of resilience  10:23 Our first LIVE event: She DESIGNS Mini Retreat Oct. 18-20 12:28 The magic of Long Story Short space  13:56 Panelists: highlighting 3 women small business owners : -Jilan Glorfield, hospitality entrepreneur & owner of Long Story Short -Estefany, Perez, co founder of Flowers Atelier -Bibbe Hansen, creator, actress, artist 14:37 The retreat activities: intentional candle making, oil painting sequencing, meal sharing 15:14 Where to sign up 16:28 Outro   Check out our first LIVE event! Join our She DESIGNS Mini Retreat at Long Story Short in Hudson, NY -October 18-20, 2024  -3 posts left for the retreat; claim your spot now! Or, join us for the LIVE Podcast Panel 4-7pm October 19  Tickets available!   Theme song for season 2: Resilient   Join our community! Follow this podcast and share with a friend! In the world of podcasts, reviews are everything! Please rate and review this episode on your favorite platform. Follow us on Instagram and let us know what you'd like for us to cover and any nominations for guests   Live your life by design. 

Learn how to connect to higher realms and your own spiritual gifts. In this special episode of Dropping In we join four world renowned spiritual teachers. Psychic medium John Holland, author and angel communicator Radleigh Valentine, psychic and cosmic coach Dougall Fraser and spirit medium, teacher and holistic healer Maureen Hancock talk about working in the spiritual realms and share tips on how you can enhance your own gifts. Recorded during a recent Facebook live, these four gifted practitioners give you a taste of what you will experience at the upcoming Answers from the Light workshop at the Omega Institute in Rhinebeck, NY October 25 to the 27th. Learn how to connect to angels, guides, and loved ones from spiritual realms during this 3-day event. Reserve your space today at eomega.org/light. Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY- October 31, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, “Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature.” The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins, and glycans which are highly tissue specific and undergo pronounced changes with age. In this new study, researchers Shweta S. Dipali, Christina D. King, Jacob P. Rose, Joanna E. Burdette, Judith Campisi, Birgit Schilling, and Francesca E. Duncan from Northwestern University's Feinberg School of Medicine, the Buck Institute for Research on Aging and the University of Illinois at Chicago used label-free quantitative proteomic methods to define comprehensive, age-dependent changes in the murine ovarian proteome and ECM in an unbiased manner. “To obtain an unbiased and comprehensive profile of age-associated alterations to the murine ovarian proteome and ECM, we used a label-free quantitative proteomic methodology.” The researchers validated conditions to enrich for the ECM prior to proteomic analysis. Following analysis by data-independent acquisition (DIA) and quantitative data processing, they observed that both native and ECM-enriched ovaries clustered separately based on age, indicating distinct age-dependent proteomic signatures. The team identified a total of 4,721 proteins from both native and ECM-enriched ovaries, of which 383 proteins were significantly altered with advanced age, including 58 ECM proteins. Several ECM proteins upregulated with age have been associated with fibrosis in other organs, but to date their roles in ovarian fibrosis are unknown. Pathways regulating DNA metabolism and translation were downregulated with age, whereas pathways involved in ECM remodeling and immune response were upregulated. Interestingly, immune-related pathways were upregulated with age even in ECM-enriched ovaries, suggesting a novel interplay between the ECM and the immune system. Moreover, the researchers identified putative markers of unique immune cell populations present in the ovary with age. These findings provide evidence from a proteomic perspective that the aging ovary provides a fibroinflammatory milieu, and their study suggests target proteins which may drive these age-associated phenotypes for future investigation.” “To our knowledge, this is the first study to utilize unbiased proteomic approaches to investigate the effect of reproductive aging on the murine ovarian proteome and matrisome. DOI - https://doi.org/10.18632/aging.205190 Corresponding authors - Francesca E. Duncan - f-duncan@northwestern.edu, and Birgit Schilling - bschilling@buckinstitute.org About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 30, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on March 24, 2023, entitled, “Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?” Expansion of pathologically activated immune suppressive myeloid cells called myeloid-derived suppressor cells (MDSC) is one of the hallmarks of cancer. In most tumor types, MDSC are represented primarily by pathologically activated neutrophils (PMN-MDSC). In this new editorial, researchers Laura Garcia-Gerique and Yulia Nefedova from the Wistar Institute discussed their team's recent study identifying a novel mechanism by which neutrophil PAD4 promotes cancer progression. “Using several transplantable and genetically engineered mouse models, we demonstrated that tumor growth was accompanied by significantly elevated enzymatic activity of neutrophil PAD4 [10]. To further clarify the role of PAD4 in tumor progression, we utilized PAD4fl/fl MRP8Cre mice with targeted deletion of PAD4 in myeloid cells, primarily neutrophils.” PMN-MDSC originate in the bone marrow and migrate to various sites including tumor tissues and premetastatic niches. These cells have a relatively short lifespan (less than 48 hours) and, therefore, are continually replaced from the bone marrow. Tumor-infiltrating PMN-MDSC possess a potent suppressive activity as they are able to inhibit both antigen-specific immune responses of T cells and non-specific anti-CD3/CD28-stimulated responses. As a result, a highly immunosuppressive environment is created in tumors, which prevents their rejection via immunological mechanisms. In addition, PMN-MDSC employ non-immunological mechanisms to facilitate tumor progression, including angiogenesis, remodeling of extracellular matrix, and production of cytokines. In patients with solid tumors, levels of MDSC in circulation and tumor tissues have been positively associated with a poor response to the therapy in many types of cancer and represent an independent indicator of poor outcomes. However, many of the details about how PMN-MDSC support cancer progression, and thus approaches for therapeutically targeting these cells, remain enigmatic. “Taken together, our study identified a new mechanism responsible for transcriptional regulation of neutrophil migration and a new mechanism by which neutrophil PAD4 is contributing to tumor progression. PAD4 inhibitors are in development and may enter early phase clinical trials in the future.” DOI - https://doi.org/10.18632/oncotarget.28369 Correspondence to - Yulia Nefedova - ynefedova@wistar.org Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28369 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PAD4, PMN-MDSC, neutrophils, neutrophil migration About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 25, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on March 24, 2023, entitled, “Genetic modifiers of p53: opportunities for breast cancer therapies.” Each day our cells encounter a wide range of genomic damage and the p53 protein arbitrates decisions of cell cycle arrest to allow repair of DNA or promote elimination of cells with malignant potential through apoptosis. In this new editorial perspective, researchers Prabin Dhangada Majhi, Aman Sharma and D. Joseph Jerry from the University of Massachusetts, Pioneer Valley Life Sciences Institute and Rays of Hope Center for Breast Cancer Research discuss TP53 mutations. The prevalence of TP53 mutations in nearly all tumors emphasizes its role as a formidable barrier that must be breached to allow oncogenic transformation. Inherited mutations in TP53 are also the primary genetic lesions found in Li-Fraumeni Syndrome (LFS), a familial cancer predisposition characterized by tumors in many tissues. However, tissues are not all equally vulnerable to disruptions in p53 function. Among women with inherited mutations in TP53, breast cancer is by far the most common tumor (Figure 1). Somatic mutations in TP53 are also prevalent in sporadic breast cancers, especially in the triple-negative subtype. The proportion rises to nearly 50% of breast cancers that exhibit impaired function of the p53 pathway based on gene expression signatures as a surrogate biomarker of p53 activity. Therefore, the breast epithelium appears to be uniquely sensitive to alterations in p53 function. “Genomewide association studies (GWAS) have identified over 300 polymorphisms that contribute to breast cancer risk [38–41]. These provide a rich resource of candidate polymorphisms that may modify the consequences of mutations in TP53.” DOI - https://doi.org/10.18632/oncotarget.28387 Correspondence to - D. Joseph Jerry - jjerry@vasci.umass.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28387 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, p53, Li-Fraumeni syndrome, genetic modifiers, breast cancer, DNA repair About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 25, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, “Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging.” Aging is inevitable and affects all cell types. Thus, yeast cells are often used as a model in aging studies. There are two approaches to studying aging in yeast: replicative aging, which describes the proliferative potential of cells, and chronological aging, which is used for studying post-mitotic cells. In this new study, while analyzing the chronological lifespan (CLS) of diploid Saccharomyces cerevisiae cells, researchers Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, and Adrianna Skoneczna from the Polish Academy of Sciences and Rzeszów University discovered a remarkable phenomenon: ploidy reduction during aging progression. “To uncover the mechanism behind this unusual process we used yeast strains undergoing a CLS assay, looking for various aging parameters.” Cell mortality, regrowth ability, autophagy induction and cellular DNA content measurements indicated that during the CLS assay, dying cells lost their DNA, and only diploids survived. The researchers demonstrated that autophagy was responsible for the gradual loss of DNA. The nucleophagy marker activation at the start of the CLS experiment correlated with the significant drop in cell viability. The activation of piecemeal microautophagy of nucleus (PMN) markers appeared to accompany the chronological aging process until the end. “Our findings emphasize the significance of maintaining at least one intact copy of the genome for the survival of post-mitotic diploid cells.” During chronological aging, cellular components, including DNA, are exposed to increasing stress, leading to DNA damage and fragmentation in aging cells. The researchers propose that PMN-dependent clearance of damaged DNA from the nucleus helps prevent genome rearrangements. However, as long as one copy of the genome can be rebuilt, cells can still survive. “The observations we made in aging research using yeast as the eukaryotic cell model may help to understand the mechanisms that prevent aneuploidy during aging or cancerogenesis in cells where chromothripsis has occurred.” DOI - https://doi.org/10.18632/aging.205102 Corresponding author - Adrianna Skoneczna - ada@ibb.waw.pl Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205102 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, genome instability, lifespan, autophagy, double-strand breaks About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, “Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses.” Dysregulated central-energy metabolism is a hallmark of brain aging. Supplying enough energy for neurotransmission relies on the neuron-astrocyte metabolic network. In their new study, researchers Alejandro Acevedo, Felipe Torres, Miguel Kiwi, Felipe Baeza-Lehnert, L. Felipe Barros, Dasfne Lee-Liu, and Christian González-Billault from Universidad de Chile, Cedenna, University of California, San Diego, Centro de Estudios Científicos (CECs), Geroscience Center for Brain Health and Metabolism (GERO), Universidad San Sebastián, and the Buck Institute for Research on Aging aimed to identify genes contributing to age-associated brain functional decline. “[...] we formulated an approach to analyze the metabolic network by integrating flux, network structure and transcriptomic databases of neurotransmission and aging.” Their findings support that during brain aging: (1) The astrocyte undergoes a metabolic switch from aerobic glycolysis to oxidative phosphorylation, decreasing lactate supply to the neuron, while the neuron suffers intrinsic energetic deficit by downregulation of Krebs cycle genes, including mdh1 and mdh2 (Malate-Aspartate Shuttle); (2) Branched-chain amino acid degradation genes were downregulated, identifying dld as a central regulator; (3) Ketone body synthesis increases in the neuron, while the astrocyte increases their utilization, in line with neuronal energy deficit in favor of astrocytes. “The genes identified here are valuable candidates for future studies to understand the molecular mechanisms of healthy brain aging and prevent brain age-associated failure using energy metabolism as a target.” DOI - https://doi.org/10.18632/aging.204663 Corresponding authors - Christian González-Billault - chrgonza@uchile.cl, and Dasfne Lee-Liu - dasfne.lee@uss.cl Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204663 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, astrocyte, neuron, brain aging, flux balance analysis, network centrality About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 23, 2023 – A new research paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, “Apoptotic cells may drive cell death in hair follicles during their regression cycle.” Intravital microscopy in live mice has shown that the elimination of epithelial cells during hair follicle regression involves supra-basal cell differentiation and basal cell apoptosis through synergistic action of TGF-β (transforming growth factor) and mesenchymal-epithelial interactions. In this process the basal epithelial cells are not internally committed to death and the mesenchymal dermal papilla (DP) plays an essential role in death induction. Given that DP cells are not necessary for completion of the cycle, only for its initiation, it is still an open question as to the mechanism that leads to the propagation of apoptosis towards the regenerative stem cell population. In their new study, researchers Bradley D. Keister, Kailin R. Mesa and Krastan B. Blagoev from the National Science Foundation, The Jane Coffin Childs Memorial Fund for Medical Research, Yale School of Medicine, Johns Hopkins University, Bulgarian Academy of Sciences, and Sorbonne Université performed a quantitative analysis of the length of hair follicles to investigate their regression cycle. “In this paper we introduced a mathematical model of the hair follicle regression cycle that postulates that the regression is initiated by the dermal papilla, but that this signal affects only the cells adjacent to it.” The data are consistent with a propagation mechanism driven by apoptotic cells inducing apoptosis in their neighboring cells. The observation that the apoptosis slows down as the apoptotic front approaches the stem cells at the end of the follicle is consistent with a gradient of a pro-survival signal sent by these stem cells. An experiment that can falsify this mechanism is proposed. “In conclusion, hair follicle regression may be governed by cell-cell induced programmed cell death, which slows down as the stem cell compartment is approached and does not affect the stem cell compartment from which the growth phase is initiated. The class of models introduced here can be used to describe the renewal kinetics of other stem cell niches like the intestinal stem cell niche [18].” DOI - https://doi.org/10.18632/oncotarget.28529 Correspondence to - Krastan B. Blagoev - kblagoev@nsf.gov Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28529 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, hair follicle, stem cells, regression cycle, mathematical model, analysis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 19, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, “GLS2 shapes ferroptosis in hepatocellular carcinoma.” In their new editorial, researchers Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, and Carol Prives from Columbia University discuss ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases. “More than a decade has passed since our group (1) as well as Hu et al., (2) identified glutaminase (GLS2) as a p53 target gene that promotes the tricarboxylic acid cycle (TCA) via α-ketoglutarate (αKG) and lowers oxidative stress via increasing glutathione (GSH) [1, 2].” Two years after this Dixon et al., [3] described a form of cell death they named ferroptosis which is caused by iron-mediated lipid peroxidation. Then, three years later, Gao et al., reported that GLS2 but not GLS1 is an inducer of ferroptosis in human cancer cells [4]. Ferroptosis had first been shown to be regulated by p53 via repression of SLC7A11 [5]. The circle was closed by a study from the Murphy group who reported that a cancer-related nonsynonymous mutation in p53 (P47S) is correlated with failure to either activate GLS2 expression or produce ferroptosis [6]. “Our recent study (Suzuki et al.) [7] has validated the ability of GLS2 to promote ferroptosis in murine models.” DOI - https://doi.org/10.18632/oncotarget.28526 Correspondence to - Carol Prives - clp3@columbia.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28526 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, ferroptosis, hepatocellular carcinoma, GLS2, p53, tumor suppression About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 18, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on April 14, 2023, entitled, “The nuclear envelope and metastasis.” In their new editorial, researchers Emily Hansen and James M. Holaska from Rowan University discuss nuclear morphology — one of the basic visual criteria used by pathologists to diagnose breast cancer. Immunofluorescence staining of the nuclear structural proteins lamin B and emerin was recommended as an effective diagnostic tool for both thyroid and breast cancer, suggesting nuclear structure is intimately tied to malignant transformation. But what role nuclear morphology plays in cancer transformation and progression remains unclear. “The most likely explanation for why cancer cells present with distinct nuclear morphology is thought to be related to the most likely route of cancer spread: the vasculature.” For a tumor to metastasize, cancer cells need to enter and exit the blood and lymphatic vessels by squeezing through extremely small gaps in the endothelium, most of which are 1.2–2 µm in diameter. While the cytoplasm is very flexible and the cytoskeleton can rearrange to fit through openings as narrow as 1 µm, the nuclear diameter (10–20 µm) and its considerable stiffness (2–10x stiffer than the cytoplasm) represent physical barriers to this process. “Thus, to enable metastasis, cancer cells must also increase their nuclear malleability.” Studies have shown that nuclear softening is associated with tumor aggressiveness and metastasis. Although nuclear softening is one of the ‘hallmarks of cancer' it remains poorly understood. Nuclear shape and stiffness are governed by a complex set of structural proteins that serve as both scaffolds and signaling proteins to influence almost all aspects of nuclear function. The best studied nucleostructural proteins are lamins, which are frequently downregulated in cancer. However, it is difficult to ascertain whether specific functional consequences are due to lamins or due to displacement of lamin-interacting proteins upon lamin loss. For example, nuclear size and shape is also governed by emerin, which binds to lamins at the nuclear envelope (NE) and upon lamin loss is retained in the endoplasmic reticulum. Like lamins, emerin is frequently mutated in cancer, with mutations in its transmembrane and actin-binding domains. “We found that in breast cancer, emerin expression in tumor tissue is significantly correlated to survival time [16]. These data suggest emerin plays a central role in pathogenic transformation and progression of malignant breast tissue.” DOI - https://doi.org/10.18632/oncotarget.28375 Correspondence to - James M. Holaska - holaska@rowan.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28375 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, emerin, metastasis, mechanotransduction, breast cancer, nucleoskeleton About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 18, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging.” Advanced age is the greatest risk factor for cardiovascular disease (CVD), the leading cause of death. Arterial function is impaired in advanced age which contributes to the development of CVD. One underexplored hypothesis is that DNA damage within arteries leads to this dysfunction, yet evidence demonstrating the incidence and physiological consequences of DNA damage in arteries, and in particular, in the microvasculature, in advanced age is limited. In their new study, researchers Samuel I. Bloom, Jordan R. Tucker, Daniel R. Machin, Hossein Abdeahad, AdeLola O. Adeyemo, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, and Anthony J. Donato from The University of Utah, Florida State University and the Veterans Affairs Medical Center-Salt Lake City began by assessing the abundance of DNA damage in human and mouse lung microvascular endothelial cells and found that aging increases the percentage of cells with DNA damage. “To explore the physiological consequences of increases in arterial DNA damage, we evaluated measures of endothelial function, microvascular and glycocalyx properties, and arterial stiffness in mice that were lacking or heterozygous for the double-strand DNA break repair protein ATM kinase.” Surprisingly, in young mice, vascular function remained unchanged which led the researchers to rationalize that perhaps aging is required to accumulate DNA damage. Indeed, in comparison to wild type littermate controls, mice heterozygous for ATM that were aged to ~18 mo (Old ATM +/−) displayed an accelerated vascular aging phenotype characterized by increases in arterial DNA damage, senescence signaling, and impairments in endothelium-dependent dilation due to elevated oxidative stress. Furthermore, old ATM +/− mice had reduced microvascular density and glycocalyx thickness as well as increased arterial stiffness. “Collectively, these data demonstrate that DNA damage that accumulates in arteries in advanced age contributes to arterial dysfunction that is known to drive CVD.” DOI - https://doi.org/10.18632/aging.205066 Corresponding author - Anthony J. Donato - tony.donato@utah.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.20506 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, DNA damage, vascular function, endothelial cell, senescence, oxidative stress, arterial stiffness About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 17, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, “GBP3-STING interaction in glioblastoma coordinates autophagy, anti-oxidative, and DNA repair programs in response to temozolomide.” In their recent editorial, researchers Jun Ma, Ziyu Wang, Clark C. Chen, and Ming Li from the University of Minnesota discussed the methylating agent, Temozolomide (TMZ). TMZ is the standard adjuvant chemotherapeutic drug for glioblastoma, which constitutes 17.7% of overall primary central nervous system tumors. The survival rate of this WHO Grade IV tumor has achieved a clinically significant prolongation of 2.5 months overall and an increase of 16.3% 2-year survival rate. However, one intractable challenge is the diverse reactions to temozolomide treatment. “The acquired resistance to the standard adjutant radiochemotherapy including temozolomide has favored the recurrence of some glioblastoma cases and has kept the milestone from moving forward for more than 15 years.” Guanylate-binding proteins (GBPs) are a group of dynamin-related large (~65 kDa) GTPases expressed in response to interferon and mediate intracellular immunity. Consisting of 7 members in humans, little is known about the function of GBPs beyond their role in innate cellular immunity. After recent years of dedication to the GBP family, its role in glioblastoma's development and recurrence has drawn great attention. “More recently, Li's lab did informatic analysis of clinically annotated glioblastoma datasets, laboratory studies of protein-protein interaction, and functional characterization after depletion or exogenous expression.” GBP family members such as GBP1, GBP2, GBP3, and GBP5 are highly elevated and play pro-tumor roles through multiple mechanisms in glioblastoma. Although other GBP family members did not show a prominent relationship with treatment resistance at the present stage, GBP3 showed significant up-regulation in response to temozolomide. Furthermore, it's revealed that high levels of GBP3 expression in glioblastoma was associated with a worsened survival after temozolomide treatment. Consistent with this observation, exogenous expression of GBP3 induced temozolomide resistance in independent patient-derived glioblastoma neurosphere lines, while GBP3 silencing conferred temozolomide sensitivity, both in vitro and in vivo. “This sensitivity was associated with the accumulation of cytoplasmic DNA fragments, suggesting the involvement of Stimulator of interferon genes (STING).” DOI - https://doi.org/10.18632/oncotarget.28370 Correspondence to - Ming Li - m2li@umn.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28370 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GBP3, MGMT, glioblastoma, temozolomide resistance, STING About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 16, 2023 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, “BMAL1 modulates senescence programming via AP-1.” Cellular senescence and circadian dysregulation are biological hallmarks of aging. Whether they are coordinately regulated has not been thoroughly studied. In this new study, researchers Sarah K. Jachim, Jian Zhong, Tamas Ordog, Jeong-Heon Lee, Aditya V. Bhagwate, Nagaswaroop Kengunte Nagaraj, Jennifer J. Westendorf, João F. Passos, Aleksey V. Matveyenko, and Nathan K. LeBrasseur from the Mayo Clinic in Rochester, Minnesota, hypothesized that BMAL1, a pioneer transcription factor and master regulator of the molecular circadian clock, plays a role in the senescence program. “Here, we demonstrate BMAL1 is significantly upregulated in senescent cells and has altered rhythmicity compared to non-senescent cells.” Through BMAL1-ChIP-seq, they showed that BMAL1 is uniquely localized to genomic motifs associated with AP-1 in senescent cells. Integration of BMAL1-ChIP-seq data with RNA-seq data revealed that BMAL1 presence at AP-1 motifs is associated with active transcription. Finally, the researchers showed that BMAL1 contributes to AP-1 transcriptional control of key features of the senescence program, including altered regulation of cell survival pathways, and confers resistance to drug-induced apoptosis. “Overall, these results highlight a previously unappreciated role of the core circadian clock component BMAL1 on the molecular phenotype of senescent cells.” DOI - https://doi.org/10.18632/aging.205112 Corresponding authors - Nathan K. LeBrasseur - lebrasseur.nathan@mayo.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205112 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, AP-1, circadian clock, cellular senescence, senolytic, transcription regulation About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 11, 2023 – A new research paper was published in Oncotarget's Volume 14 on October 4, 2023, entitled, “Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells.” Drug resistance is a major barrier against successful treatments of cancer patients. Gain of stemness under drug pressure is a major mechanism that renders treatments ineffective. Identifying approaches to target cancer stem cells (CSCs) is expected to improve treatment outcomes for patients. In their new study, researchers Astha Lamichhane, Gary D. Luker, Seema Agarwal, and Hossein Tavana from The University of Akron, University of Michigan and Georgetown University aimed to elucidate the role of cancer stemness in resistance of colorectal cancer cells to targeted therapies. “[...] we developed spheroid cultures of patient-derived BRAFmut and KRASmut tumor cells and studied resistance mechanisms to inhibition of MAPK pathway through phenotypic and gene and protein expression analysis.” They found that treatments enriched the expression of CSC markers CD166, ALDH1A3, CD133, and LGR5 and activated PI3K/Akt pathway in cancer cells. The team examined various combination treatments to block these activities and found that a triple combination against BRAF, EGFR, and MEK significantly reduced stemness and activities of oncogenic signaling pathways. This study demonstrates the feasibility of blocking stemness-mediated drug resistance and tumorigenic activities in colorectal cancer. “Our approach to identify mechanisms of drug resistance of patient-derived cancer cells to targeted therapies and develop effective treatments is promising toward cancer precision medicine.” DOI - https://doi.org/10.18632/oncotarget.28517 Correspondence to - Hossein Tavana - tavana@uakron.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28517 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, drug resistance, cancer stem cells, patient-derived tumor model, colorectal cancer, combination treatment About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study.” Pathways explaining racial/ethnic disparities in dementia risk are under-evaluated. In their new study, researchers May A. Beydoun, Hind A. Beydoun, Marie T. Fanelli-Kuczmarski, Jordan Weiss, Michael F. Georgescu, Osorio Meirelles, Donald M. Lyall, Michele K. Evans, and Alan B. Zonderman from the National Institute on Aging, Fort Belvoir Community Hospital, Stanford University, and the University of Glasgow examined those disparities and their related pathways among UK Biobank study respondents (50–74 y, N = 323,483; 3.6% non-White minorities) using a series of Cox proportional hazards and generalized structural equations models (GSEM). “The present study examines pathways that might explain racial, ethnic, and socio-economic disparities in AD or all-cause dementia in a large cohort study, the UK Biobank. Our study used several methodologies, including structural equation modeling coupled with survival analysis techniques to examine complex mediating effects between race, ethnicity, socioeconomic status, and dementia or AD [Alzheimer's disease] risk in a sex-specific manner focusing on lifestyle, biological and cognitive pathways. It is also an attempt at replicating a previous study conducted among US older adults [24].” Results: After ≤15 years, 5,491 all-cause dementia cases were diagnosed. Racial minority status (RACE_ETHN, Non-White vs. White) increased dementia risk by 24% (HR = 1.24, 95% CI: 1.07–1.45, P = 0.005), an association attenuated by socio-economic status (SES), (HR = 1.12, 95% CI: 0.96–1.31). Total race-dementia effect was mediated through both SES and Life's Essential 8 lifestyle sub-score (LE8LIFESTYLE), combining diet, smoking, physical activity, and sleep factors. SES was inversely related to dementia risk (HR = 0.69, 95% CI: 0.67, 0.72, P < 0.001). Pathways explaining excess dementia risk among racial minorities included ‘RACE_ETHN(−) → SES(−) → DEMENTIA', ‘RACE_ETHN(−) → SES(−) → Poor cognitive performance, COGN(+) → DEMENTIA' and ‘RACE_ETHN(−) → SES(+) → LE8LIFESTYLE(−) → DEMENTIA'. “Pending future interventions, lifestyle factors including diet, smoking, physical activity, and sleep are crucial for reducing racial and socio-economic disparities in dementia.” DOI - https://doi.org/10.18632/aging.205058 Corresponding author - May A. Beydoun - baydounm@mail.nih.gov Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, dementia, Alzheimer's disease, health disparities, socio-economic status, structural equations modeling About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 10, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “High-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults.” Seasonal influenza contributes to a substantial disease burden, resulting in approximately 10 million hospital visits and 50 thousand deaths in a typical year in the United States. 70 - 85% of the mortality occurs in people over the age of 65. Influenza vaccination is the best protection against the virus, but it is less effective for the elderly, which may be in part due to differences in the quantity or type of B cells induced by vaccination. In their new study, researchers Meng Wang, Ruoyi Jiang, Subhasis Mohanty, Hailong Meng, Albert C. Shaw, and Steven H. Kleinstein from Yale University / Yale School of Medicine investigated this possibility. “[...] we sorted pre- and post-vaccination peripheral blood B cells from three young and three older adults with strong antibody responses to the inactivated influenza vaccine and employed single-cell technology to simultaneously profile the gene expression and the B cell receptor (BCR) of the B cells.” Prior to vaccination, the researchers observed a higher somatic hypermutation frequency and a higher abundance of activated B cells in older adults than in young adults. Following vaccination, young adults mounted a more clonal response than older adults. The expanded clones included a mix of plasmablasts, activated B cells, and resting memory B cells in both age groups, with a decreased proportion of plasmablasts in older adults. Differential abundance analysis identified additional vaccine-responsive cells that were not part of expanded clones, especially in older adults. “To summarize, we showed a quantitative difference in B cell response following vaccination between age groups, with expansion dominated by plasmablasts in the young, and activated B cells in older adults. [...] Overall, this study provides insights into the B cell vaccine response differences between young and older adults and may be beneficial to design more effective vaccines in the older age groups.” DOI - https://doi.org/10.18632/aging.204778 Corresponding authors - Albert C. Shaw - albert.shaw@yale.edu, and Steven H. Kleinstein - steven.kleinstein@yale.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204778 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, B cell receptor, repertoire, clonal expansion, single-cell RNA-seq About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 9, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on October 4, 2023, entitled, “STAT3 as a biologically relevant target in H3K27M-mutant diffuse midline glioma.” Pediatric H3K27M-mutant diffuse midline gliomas (DMGs), including those formerly classified as diffuse intrinsic pontine gliomas (DIPG), are uniformly lethal central nervous system malignancies. Children diagnosed with these tumors have an extremely poor prognosis, with a median survival of approximately 12 months. The current standard of care for DMG includes possible biopsy for diagnostic confirmation and a 6-week course of palliative radiation. Despite enormous effort toward the development of novel therapeutics in DMG, chemotherapy remains ineffective in this disease. “Indeed, over 100 clinical trials for chemotherapeutics in DMG have failed to show therapeutic benefit [5].” In their new editorial perspective, researchers Jacob B. Anderson, Samantha M. Bouchal, Liang Zhang, and David J. Daniels from the Mayo Clinic discussed the currently available literature and their recent study on the Signal Transducer and Activator of Transcription (STAT) as a biologically relevant therapeutic target in H3K27M-mutant DMGs. In their recently published manuscript, the lab performed a screen of drugs currently in clinical use or clinical trials for efficacy against a library of H3K27Mmutant and H3-wildtype patient-derived cell lines. The results of this drug screen identified the STAT3 signaling pathway as a novel target in DMG. “Until recently, however, STAT3 was not a druggable target.” DOI - https://doi.org/10.18632/oncotarget.28516 Correspondence to - David J. Daniels - daniels.david@mayo.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28516 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, H3K27M, DMG, DIPG, midline glioma, STAT3 About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 4, 2023 – A new review paper was published in Oncotarget's Volume 14 on September 28, 2023, entitled, “UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.” UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, researchers Meghan J. Price, Annee D. Nguyen, Jovita K. Byemerwa, Jasmine Flowers, César D. Baëta, and C. Rory Goodwin from Johns Hopkins Hospital, Duke University, Stanford University, Duke Center for Brain and Spine Metastasis, and Duke Cancer Institute classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. “As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.” DOI - https://doi.org/10.18632/oncotarget.28514 Correspondence to - C. Rory Goodwin - rory.goodwin@duke.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28514 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, UDP-6 glucose dehydrogenase, UGDH, oncology, cancer biology About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 4, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” Target discovery is crucial for the development of innovative therapeutics and diagnostics. However, current approaches often face limitations in efficiency, specificity, and scalability, necessitating the exploration of novel strategies for identifying and validating disease-relevant targets. Advances in natural language processing have provided new avenues for predicting potential therapeutic targets for various diseases. In their new study, researchers Diana Zagirova, Stefan Pushkov, Geoffrey Ho Duen Leung, Bonnie Hei Man Liu, Anatoly Urban, Denis Sidorenko, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W. Pun, Ivan V. Ozerov, Alex Aliper, and Alex Zhavoronkov from Insilico Medicine present a novel approach for predicting therapeutic targets using a large language model (LLM). “We trained a domain-specific BioGPT model on a large corpus of biomedical literature consisting of grant text and developed a pipeline for generating target prediction.” This study demonstrates that pre-training of the LLM model with task-specific texts improves its performance. Applying the developed pipeline, the researchers retrieved prospective aging and age-related disease targets and showed that these proteins are in correspondence with the database data. Moreover, they propose CCR5 and PTH as potential novel dual-purpose anti-aging and disease targets which were not previously identified as age-related but were highly ranked in their approach. “Overall, our work highlights the high potential of transformer models in novel target prediction and provides a roadmap for future integration of AI approaches for addressing the intricate challenges presented in the biomedical field.” DOI - https://doi.org/10.18632/aging.205055 Corresponding author - Alex Zhavoronkov - alex@insilico.com Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205055 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, transformers, deep learning, therapeutic target discovery, aging biomarkers, human aging About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- October 3, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on September 25, 2023, entitled, “DISE, an ancient anti-cancer mechanism that senses mutational load in cancerous cells?” In their new editorial, researchers Monal Patel and Marcus E. Peter from Northwestern University discuss a recent breakthrough in cancer therapy. Despite the multiple advances in therapy, cancer remains one of the most common causes of death globally. It is a systemic disease affecting people of all ages and originates at the level of single cells which, upon acquisition of mutations, become neo-plastically transformed. Cell division is the biggest risk factor for the accumulation of mutations, explaining why all multicellular organisms which evolved about 2 billion years ago, are prone to cancer. Given the recent achievements in cancer treatment with immune checkpoint blockade therapies, multicellular organisms may have developed the immune system as a mechanism to eradicate cancerous cells. “However, the immune system arose relatively recent, ~500 million years ago [3].” Moreover, studies have shown that cancer cells can become resistant to the anticancer activity of both the innate and the adaptive immune system. Therefore, while the immune system is important, it is likely not the most vital machinery that emerged in multicellular organisms to prevent cancer formation. The researchers believe that there are other more effective and archaic anti-cancer mechanisms that are conserved during evolution. Of note, RNA interference (RNAi) is a highly conserved biological mechanism for silencing gene expression. While RNAi likely emerged as a defense tool against viruses and other foreign nucleic acids, it has also evolved to have other activities in the cells. The team's research has identified a new evolutionarily conserved RNAi-based form of cell death that targets essential survival genes: Death Induced by Survival gene Elimination (DISE). “DISE was discovered through our work on CD95 and its ligand, CD95L, where we found that more than 80% of 26 different short interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) derived from the two genes, killed multiple cancer cell lines via simultaneous activation of multiple cell death pathways; and we were unable to find a way to inhibit this form of cell death [9].” DOI - https://doi.org/10.18632/oncotarget.28466 Correspondence to - Marcus E. Peter - m-peter@northwestern.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28466 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, cell death, evolution, RNAi, short RNAs About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

BUFFALO, NY- October 2, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Gene expression signatures of human senescent corneal and conjunctival epithelial cells.” In this new study, researchers Koji Kitazawa, Akifumi Matsumoto, Kohsaku Numa, Yasufumi Tomioka, Zhixin A. Zhang, Yohei Yamashita, Chie Sotozono, Pierre-Yves Desprez, and Judith Campisi from the Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine and Lawrence Berkeley National Laboratory aimed to investigate the senescent phenotypes of human corneal and conjunctival epithelial cells. “Here, we induced cellular senescence in human corneal and conjunctival epithelium using X-irradiation, and analyzed gene expression profiles of each cell type to determine the characteristics of senescent ocular surface cells.” The team examined cell morphology, senescence-associated β-galactosidase (SA-β-gal) activity, cell proliferation, and expression of senescence markers (p16 and p21). RNA sequencing analysis was conducted to compare gene expression profiles between senescent and non-senescent cells. Finally, the potential involvement of senescent cells in the pathogenesis of ocular surface diseases was investigated. X-irradiated corneal and conjunctival epithelial cells exhibited typical senescence phenotypes, i.e., flattened morphologies, increased SA-β-gal activity, decreased cell proliferation, and increased expression of senescence markers, p16 and p21. RNA-seq analysis revealed substantial differences in gene expression profiles between senescent corneal (SCo) and conjunctival epithelial cells (SCj). Moreover, SCj were detected in pathological conjunctival tissues associated with limbal stem cell deficiency (LSCD) due to Stevens-Johnson syndrome or chemical burns, potentially being involved in abnormal differentiation. “This study highlights the cellular and molecular characteristics of senescent ocular surface cells, particularly in SCj that show abnormal keratin expression, and their potential roles in severe ocular surface diseases and pathology.” DOI - https://doi.org/10.18632/aging.205113 Corresponding authors - Koji Kitazawa - kkitazaw@koto.kpu-m.ac.jp, and Judith Campisi - jcampisi@buckinstitute.org Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205113 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, cornea, conjunctiva, Stevens-Johnson syndrome, limbal stem cell deficiency About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Steve Scott spoke via Zoom with TABLZ CEO Frazer Nagy.PHOTO: NEW YORK, NY - OCTOBER 1: Atmosphere at Operation Warrior Shield Luncheon Benefiting Operation Canine Companion at Patsy's Italian Restaurant of New York on October 1, 2022 in New York City. (Photo by Michael Ostuni/Patrick McMullan via Getty Images)

New York City has a problem with repeat offenders. We heard from NYPD Chief of Department Kenneth Corey about one specific case.  Juliet Papa has more.NEW YORK, NY - OCTOBER 24: The New York Police Department increased officer presence by approximately 1,200 additional overtime officer shifts each day on the subway to keep people safe after New York Governor Kathy Hochul and New York City Mayor Eric Adams on Saturday, Oct. 19, announced a plan to increase the presence of police officers in the transit system in New York City, New York on October 24, 2022. (Photo by Lokman Vural Elibol/Anadolu Agency via Getty Images)

BUFFALO, NY- October 27, 2022 – On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by MEDLINE/PubMed and PubMed Central/PubMed. *** The United States government is firmly committed to making credible biomedical research available to the public. In operation since 1996, PubMed is an online biomedical literature database operated by the U.S. National Institutes of Health (NIH). PubMed provides free access to over 34 million citations from MEDLINE, PubMed Central (PMC) and the National Center for Biotechnology Information databases. Started back in the 1960s, MEDLINE is a large bibliographic citation and abstract database for life science articles in journals and other scientific publications. MEDLINE now contains more than 29 million references to articles in over 5,200 journals. In 2000, PMC was launched as a free, full-text archive of biomedical and life sciences journal literature. Both MEDLINE and PMC are operated by the NIH's National Library of Medicine. Importantly, PubMed and MEDLINE use the same controlled vocabulary thesaurus, called Medical Subject Headings, or MeSH, to ensure that content is easily searchable and properly indexed. The vast scope of scholarly publications in MEDLINE is why Oncotarget is proud to have its papers indexed by this database. Oncotarget, launched in 2010, is a peer-reviewed, open-access and primarily oncology-focused biomedical journal. This journal has international reach—publishing research from world-renowned institutions. The cornerstones of Oncotarget's publishing practices are insightful peer review, scientific integrity, rigorous ethical standards, up-to-date tools and resources, and a commitment to local and scientific communities. Oncotarget aims to maximize research impact, eliminate borders between specialties and foster the application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact media@impactjournals.com

Gubernatorial Candidate, Rep. Lee Zeldin of NY, talks about the shooting that happened outside of his home last night related to gang violence; a bullet fell 30 ft. from his 16 year old daughters who were sitting at the table doing homework. See omnystudio.com/listener for privacy information.

Get tickets for Andrea von Kampen's upcoming tour dates HERE. October 7 - New York, NY*October 9 - Philadelphia, PA*October 12 - Washington, DC*October 13 - Carrboro, NC*October 14 - Charlotte, NC*October 16 - Nashville, TN*October 17 - Decatur, GA*October 26 - Mill Valley, CA^October 27 - Ashland, OR^October 28 - Bend, OR^October 29 - Portland, OR^*with Dead Horses & ^ with DarlingsideYou can find Andrea's music on Spotify, Apple, Amazon, YouTube, and anywhere else that music can be streamed or downloaded!Follow Andrea on Instagram, Facebook, Twitter, and TikTok. Andrea's official website can be found at AndreavonKampen.com. Finally, if you would like to receive updates about new music, tour dates, podcast episodes, and more you can sign up for Andrea's mailing list HERE.  

Episode 268: This week Will Hutnick joins the podcast to discuss his large mixed media abstractions created with a range of materials.   Will currently has a work in Artists Draw Their Studios (curated by Michelle Weinberg) at the Kleinert/James Center for the Arts at Byrdcliffe (Woodstock, NY) October 9 – November 21 and Mediated Landscapes (curated The post Will Hutnick appeared first on Studio Break.

Today's blockchain and cryptocurrency news Brought to you by ungrocery.com Nexo Not Guilty in NY France Piloting CBDC Russia Replacing Dollar with Digital and Other Assets

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Tim Olson   Tim Olson is an author, teacher, Principal. Pastor, and life coach with forays into audio publishing, radio hosting, and home remodeling. His understanding of father-child relationships was fostered through years of observation and application in education, coaching clients around the world, and working with the National Fathering Ministry in Minnesota and Ukraine. As a business life coach, it was through coaching family business owners that the significant connections between a father and his children (or with his own father) finally gelled into observable patterns that helped form the basis for his coaching and for his book, The Legacy of Absence. Through it all, he's found his way to helping others to discover who they are meant to be and to become that person. He and his wife, Kay, have been married for 54 years and are blessed with three children, six grandchildren, four bonus grandchildren, and four great-grandchildren. They make their home in New Hope, MN.   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to become an intentional dad LINK TO PART 1 of the conversation with Tim Olson  timolsonauthor.com 2:18 - Images from the book: present father, the involved father, the passive father and the absent father   LINKS to the images: https://dadawesome.org/195/  2:49 - "You can be present physically and not present emotionally, spiritually and intellectually. And you know, that's actually even worse." Sharing statistics on risk of pathological behavior in children. 6:05 - Story from Ukraine of two fathers that work out of the home - one is absent, and one is still intentional even though not physically close - and the stark difference in the success of the kids 9:06 - Working with inmates, what do they wish they had from their dads? 10:48 - "We've realized that death is not as bad for kids as being abandoned and just just a dad who's overworking is abandonment. We all abandoned our kids. And every kid, every person has been abandoned to some extent, some so little you don't even recognize it. And we don't realize that that's what it is. We just remember the not being chosen part." 11:34 - Describing the reconciliation process 14:21 - "[Dad's role is] to prepare us to face the world on our own. And so he does that primarily by teaching us four things and developing them in us. And those four things are: self-esteem, confidence, maturity and identity. And identity is perhaps the most important because that describes who we are and whose we are.... These are perhaps the most important words that a father can say, I believe: 'You are mine. You belong to me. I love you.' That's identity." 17:17 -  "How we deal with the hurt and wounds of our own father's failures, determines our ability to be good fathers and mothers, you know, to our own children. 17:38 - Quoting Richard Rohr - "If we do not transform our pain, we will most assuredly transmit it." 17:56 -  In Louis Meade's book, he says to forgive is to set the prisoner free and then discover that the prisoner was me." 26:27 - 4 Things he shared with his kids: 26:32 - "I know that things happened in our relationship that hurt you. I said things and did things that hurt you. Even now, I didn't even know it. And I want you to know that I would never do anything like that on purpose intentionally, but I know it happened. And so I want to ask you to please forgive me for those things." 27:35 - "I am no longer your parent and you are no longer my child. Well, that sounds pretty offensive at first. I said instead, from now on, I am just your father and you are just my son." 29:27 - "It would please me more than anything to continue to be able to speak into your life." 30:15 - "No matter what you do, with your decisions and with your life, good or bad, it will never change how much I love you. That will never change." 33:01 - Quote from Dr. Martin Luther King, Jr. "Our lives begin to end the day we become silent about the things that matter."    Episode Links:   https://timolsonauthor.com/ https://www.dadsfirst.org/ Tim's book - The Legacy Of Absence FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team  

In our second installment of Pizza & Fairytales, we discuss how Yoko draws Paul into her mind games with John. Highlights of Paul's ensuing visit to John in LA include the Toot ‘n' Snore jam session and a peculiar Polaroid message sent to Jann Wenner.   Back in New York, John gives his last ever concert performance and the Beatles are finally, legally dissolved. Afterwards, Paul invites John to a rendezvous in New Orleans, setting the stage for a possible Lennon-McCartney reunion. __   SOURCES Loving John, MAY PANG (1983) Many Years From Now, BARRY MILES (1997) Chris Salewicz interview w/ Paul McCartney (Sept 1986) “Ballad of Yoko” BBC programme (1998) “Can't buy me love: Yoko tells how Paul saved her marriage to John” The Times UK (Oct 9, 2010) Man on the Run, TOM DOYLE (2013) Sticky Fingers, JOE HAGAN (2017) John & Yoko Interview w/ David Wigg St. Regis Hotel, NY (October, 1971) Sandra Shevey Interview w/ John & Yoko (1972) John Lennon and Yoko Ono, interview w/ Jonathan Cott for Rolling Stone: Yoko Ono and her sixteen-track voice. (March 18th, 1971) Tony King Interview w/ BBC In My Life: John Lennon Remembered (1990) John Lennon interview w/ Alan Freeman (January, 1975) Harry Nilsson Interview w/ Geoffrey Guiliano (Feb 17, 1984) Life: “Paul McCartney talks about the Beatle breakup and his new life” (April 16th, 1971) Audio letter to John Lennon from Mimi Smith as excerpted on Lost Lennon Tapes (early 1970s)   PLAYLIST Move on Fast YOKO ONO Let Me Roll it PAUL MCCARTNEY & WINGS Meat City JOHN LENNON Stand By Me, LENNON/McCARTNEY and PALS Bluebird (One Hand Clapping) PAUL McCARTNEY & WINGS I'll Never Leave You HARRY NILSSON Whatever Gets You Thru the Night (live) ELTON JOHN & JOHN LENNON I Saw Her Standing There (live) ELTON JOHN & JOHN LENNON Bless You JOHN LENNON Beef Jerky JOHN LENNON You Gave Me the Answer PAUL McCARTNEY & WINGS    

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Tim Olson   Tim Olson is an author, teacher, Principal. Pastor, and life coach with forays into audio publishing, radio hosting, and home remodeling. His understanding of father-child relationships was fostered through years of observation and application in education, coaching clients around the world, and working with the National Fathering Ministry in Minnesota and Ukraine. As a business life coach, it was through coaching family business owners that the significant connections between a father and his children (or with his own father) finally gelled into observable patterns that helped form the basis for his coaching and for his book, The Legacy of Absence. Through it all, he's found his way to helping others to discover who they are meant to be and to become that person. He and his wife, Kay, have been married for 54 years and are blessed with three children, six grandchildren, four bonus grandchildren, and four great-grandchildren. They make their home in New Hope, MN.   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to become an intentional dad 2:55 - Praying for his grandsons-in-law 4:55 - National Fathering Ministry - https://www.dadsfirst.org/ 6:03 - "Dr. Richard Green, a former superintendent of Minneapolis schools. And he said to us, if the kids come to us for kindergarten and do not have an involved father or an involved grandfather, they are already lost to us"  - This conversation was the purpose for working with black urban fathers of preschool children. 6:46 - Working with fathers in Ukraine - starting a fatherhood ministry that has impacted the nation 8:06 - Ukrainian college women drawing where dad sits in the family circle 9:22 - "The father for a time was even taken out of the Russian dictionary.  And and if you go back in history and I covered some of this in my book about how that worked with communism and and Marxism, ...  they did their best to eliminate the father from the family and the the government was supposed to be the ones who essentially raised the children by way of the mothers...the government was in charge." 12:26 - Malachi 4:5-6 12:46 - Gordon Dalby is a great spokesperson about fathering, and he [share that].... the brokenness in this world between children and fathers reflects the brokenness between humanity and God." 14:16 - "We have to try to find the right path or we become complicit in crimes against it." 19:28 - "One of the things that I heard them say often was, 'you know, my grandfather was like this, my dad was like this, I'm like this, and my kids will be like this, and there's nothing I can do about it. It's just the cards we were dealt.' And I would say to him, You know what? That is a lie right out of the pit of hell, yes, you can change. You may not be able to change how tall you are and the color of your skin or anything like that, but you can change your personality, you can change your character quality, you can change the things you want and don't want to pass on to your kids. You can do that." 20:56 - Story of reconciliation with his own son and not wanting to pass on generational sins 31:30 - "Christ's example shows us as leaders in our areas of strength as dads to come underneath our children and our wives to lift and encourage and to praise and to pray for and to make them who God intended them to be. But you know, the moms, their wives have their areas of strength just as strong and in their job then is in their areas of strength is to come under us as fathers and to pray for us and lift us and encourage us and support us to be the best dads we can be. And so there's this mutual coming under, this mutual submissiveness, and it's the strongest, not the weakest, that submits."    Episode Links:   https://www.dadsfirst.org/ Tim's book - The Legacy Of Absence FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript Coming Soon!

Our first episode follows John and Paul's reconciliation in 1972-1973, John & Yoko's decision to separate, John's move to Los Angeles with May Pang and John's steps toward self-acceptance. --- TW: violence SOURCES Interview w/ Barbara Graustark for Newsweek (1980) This Is Not Here Press Conference, Everson Museum in Syracuse, NY (October 8, 1971) Gary Von Syock, LiveforLiveMusic.com  (2015) Lennon: the Man, the Myth, the Music TIM RILEY (2011) You Never Give Me Your Money, PETER DOGGETT (2009) Elliot Mintz Interview w/ John and Yoko (1973) John Lennon on Weekend World  (April 8, 1973) Paul McCartney to Nicky Horne (1973) JOHN LENNON THE LIFE, Philip Norman (2008) Daily Beast, YOKO ONO (Oct 13, 2015) John Lennon, interview w/ Lisa Robinson for Hit Parader (December, 1975)  The Gay Liberation Book (1972) Loving John, MAY PANG (1983) John Lennon on Women's Hour (May 28, 1971) John Lennon Interview w/ Sandra Shevey (1972) John Lennon Interview for PLAYBOY (1980) Paul McCartney Interview, Telegraph UK (Aug 25, 2009) PLAYLIST I Know, I Know JOHN LENNON Silly Love Songs WINGS New York City JOHN & YOKO Get On the Right Thing PAUL McCARTNEY & WINGS Mamunia Paul McCartney & WINGS I Know I Know (demo) JOHN LENNON No Words PAUL McCARTNEY & WINGS Mind Games JOHN LENNON I Can't Stand the Rain ANN PEEBLES When the Night (Newcastle 73) WINGS Move on Fast YOKO ONO

dadAWESOME We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Trent Walker   Trent and Siobhán are a husband and wife singer-songwriter duo raising their 5 sons on the road full time in a nearly vintage Foretravel motorhome. Their original songs speak of adventure, bravery, reaching out to others and trusting in a God who never fails. Their family motto has become to "live simply, so that others may simply live." Come watch as they cross the nation in search of the joys of life and sharing them with others. If you are interested in having us come and share our song and journey with your church or even a group of friends at your home, please give us a shout. We would love to come and be a blessing wherever we can.   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad Donate to F4F 5:39 - Dallas Willard - A Life Without Lack 6:18 - Why call the channel EVERYDAY Family Adventures? 7:02 - "Life is pretty awesome. So let's start with that basis and know that I don't want my life to be boring. And that's a choice. And so that's an everyday choice. And so we're going to choose quite effectively to make every day an adventure in some way." 7:47 - "I'm going to choose to have hope and look at tomorrow with opportunity. And I think that we as dads have to go before our kids in that in that optimism, especially today when the world is in a hopeless place." 9:03 - Song: Speak: https://youtu.be/PeT8LQOffDs 14:18 - "I mean, that was kind of the faith and the words that needed to come out of our mouth and begin coming out of our mouth during that time when we were really struggling and we were praying every morning, getting on our knees was just this like, I am not going to leave this place until I get the favor of the Lord because I am done with being passive. I'm done with being like, woe is me. I'm going to I'm going to choose to believe in in this God that I've spoken about all my life, but really never took action steps in it." 14:42 - Missions as a family: "Live simply so that others may simply live." AND "To inspire people to find their own adventure in life, something that will bring them joy while bringing others joy as well." 23:34 - "I believe, the more you worship God, the more you get the heart of Christ and the heart of Christ to be around people and love people. And so I believe the more you look at Jesus, the more you fix your eyes on Jesus and the more you're singing about him and glorifying him and maybe getting your eyes off of yourself. Jesus keeps doing this wild thing. You look at him more and he keeps showing you where his heart is and his heart is the love the world." 27:14 - Wanting the heart to grow bigger.   Episode Links:   www.trentandsiobhan.com YouTube Channel:  FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team Conversation Transcript coming soon :)

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Jackie Bledsoe   Jackie Bledsoe is a professional blogger, author, and speaker, but first and foremost a husband and father, who encourages men to better lead and love their families through his blog, JackieBledsoe.com. He's a contributor to All Pro Dad, Babble.com, Good Men Project, and Huffington Post. His work has been featured on Yahoo!, USA Football, MichaelHyatt.com, and more. Jackie, who has been happily married to his wife, Stephana, since June of 2001, lives in Indianapolis, Indiana, with their daughter and two sons.   Wild at Heart BASIC in Northern Wisconsin When? October 28th through the 31st, 2021 (event ends at 10am Sunday) Where? HoneyRock Camp 8660 Honey Rock Rd, Three Lakes, WI 54562 What is BASIC? Wild at Heart BASIC is Wild at Heart Boot Camp led by John Eldredge and his team through video sessions in your local area. RSVP by signing up here: https://sites.google.com/view/wild-at-heart-basic/home   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Donate to F4F Happily Married Couples How I Built This and Stayed happily married podcast BOOK: The Seven Rings of Marriage dadAWESOME Nudge - Text 651-370-8618 Wild at Heart Basic Event - Check out link to Register The Seven Habits of Highly Effective People by Steven Covey 4:33 - The biggest rocks related to parenting and marriage 8:02 - heart attack on Thanksgiving 2018 10:35 - Blog post - “what you must teach your daughter before she turns 16” 10:56 - “Preparing your daughter for marriage” blog post 11:32 - Advice: Model what you want to see in your daughter's future husband - model that in how you treat your wife 14:58 - teaching his daughter to manage finances 19:56 - Marriage advice 21:59 - So know that if you're in a hard season right now, just keep the course, stay the course, stay. ...do not grow weary in well doing. But at the proper time You receive a harvest if you do not give up. So that's the word that I give to you dads as well. It can be tough right now, but keep doing things that you know are going to lead to the end that you want in your marriage and your fatherhood and your business, whatever it is, and trust that that harvest will come at some point. Wild at Heart Basic Event - 4 days, 3 nights. Honey Rock camp in WI    Episode Links:   https://jackiebledsoe.com/ https://happilymarriedcouples.com/ FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team        

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Ken Castor    After thirty years of next-generation ministry, Dr. Ken is balding in his hairline but still bold in his faith. He is the Family and NextGen Pastor at Wooddale Church. He served as the Professor of Youth Ministry at Crown College for over a decade and in nextgen ministry for two decades before that. Ken is the “Blue Letters Editor” of the Award-winning Jesus-Centered Bible, and has authored numerous discipleship resources like Grow Down and Make a Difference. He's also a nerdy Cubs fan, the founder of NEXT Ministry Conferences, has several Chuck-Taylors, and enjoys living in Minnesota with his brilliantly witty and slightly freezing family.   Wild at Heart BASIC in Northern Wisconsin   When? October 28th through the 31st, 2021 (event ends at 10am Sunday) Where? HoneyRock Camp 8660 Honey Rock Rd, Three Lakes, WI 54562 What is BASIC? Wild at Heart BASIC is Wild at Heart Boot Camp led by John Eldredge and his team through video sessions in your local area. RSVP by signing up here: https://sites.google.com/view/wild-at-heart-basic/home   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes: Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad Donate to F4F Local gold SPONSOR: Accelerate Business Solutions - https://www.xceleratenow.com/ Ken Castor - Family pastor at Wooddale Church - https://wooddale.org/ 3:47 - Unpacking the meaning of resilience in the family. Developing spiritual grit. 8:52 - Wishing he had spent more time preparing the meals together as a family instead of just one parent preparing the meal and rushing to the table. 12:39 - “Every facet of life as a dad, it's hard to give up what I'm good at and let my kid do it not as good.” 19:35 - “There are some intentional rhythms I've built into my life so that my kids would know that, hey, my dad's all about Jesus. Like that's been my goal. But I can be as intentional as I want but if in the unintentional moments my kids see a jerk or they see somebody who's living a different lifestyle or who's talking bad about their wife or whatever, it those moments are the ones that actually matter.” 22:27 - Discussing the story of the prodigal son with an emphasis on the father. 28:02 - “The measurement of a good father is not based upon the behavior and outcome of the children. The measurement of the good father is, does he reflect God, the father, and the character and the heart that all of his children would be in relationship with him at home." 32:13 - The story of adoption 34:47 - On the season of waiting for fatherhood (waiting for pregnancy, adoption, etc) “That season of preparation is... The principles that you're working on in your heart and your soul and faith in that season of preparation are the same resources that you will turn to as a dad so that that season of waiting. You can't be impatient and do fatherhood well.” Wild at Heart Basic Event - 4 days, 3 nights. Honey Rock camp in WI    Episode Links:   https://kencastor.com/ Books & Resources from Ken Castor FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript https://dadawesome.org/191notes  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Dr. Greg Bourgond   As President and Founder of Heart of a Warrior Ministries, Dr. Greg Bourgond, has taught in graduate / post-graduate schools and ministry organizations, and has spoken and preached in many churches and ministry contexts around the world. He is also the author of many award winning books. He has been happily married for 48 years and enjoys time with his grandchildren every chance he gets. His previous experience includes ten years in the defense industry and commercial business, and over twenty years in various ministry positions. He also completed twenty-nine years of active and reserve duty in enlisted and officer ranks in the U.S. Navy. He has received degrees from Chapman University, Bethel Seminary and Nova Southeastern University. He has also completed post graduate work at Harvard University. He has also twice been C.S. Lewis Visiting Scholar-in-Residence at the Kilns in Headington England.   Wild at Heart BASIC in Northern Wisconsin   When? October 28th through the 31st, 2021 (event ends at 10am Sunday) Where? HoneyRock Camp 8660 Honey Rock Rd, Three Lakes, WI 54562 What is BASIC? Wild at Heart BASIC is Wild at Heart Boot Camp led by John Eldredge and his team through video sessions in your local area. RSVP by signing up here: https://sites.google.com/view/wild-at-heart-basic/home   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad Donate to F4F 3:13 - Heart of a Warrior Ministries Dr. Bourgond's Books 8:05 -  "God wires men cause to die for, a challenge to embrace, and loved ones to protect." 10:32 - "Robert Lewis, who coined the definition of authentic manhood, is to reject passivity, accept responsibility, lead courageously and wait on God's reward." 10:55 -  David Morrow published the book Why Men Hate to Go to Church. 14:11 - Above all else, guard your heart for from it becomes the wellspring of your life. - Proverbs 4:23 14:55 - "Whatever is stored in your heart will manifest itself in overt behavior that either bring glory and honor to God or dishonor and shame." 16:10 - "What I found out that men have an ability, especially in Western culture, to proclaim a belief system that bears little correlation with how they behave. There's an inconsistency and incongruity and incoherence, but how they behave over time will give you an insight into what they truly believe at the core of their being." 16:42 - "The decisions that we make are always processed through the values we hold, even if we can't articulate them." 22:44 -  "It will always be the case in Western culture, nobody really cares what you had to say, until they observe how you live. And if you try to live a life of integrity and honor under God's authority, people ultimately want to hear what you have to say, even if they disagree with you. Why? Because they can't get past a life well lived." 23:01 - "Living intentionally in the same direction over an extended period of time will have a greater impact on your children than anything you could possibly say." 24:21 - "And what I learned over the course of time is that sometimes God called you to be a sage on the stage. In other times, he wants you to be a guide by the side. And I understood that parenting needed to be situational. That you needed to change your leadership style with the confidence and the competence being demonstrated by that child in whatever task you give them." 26:46 - "If your child is a skeptic, simply answer the questions they're asking. If they're cynics, simply question the answers they're giving me." 35:01 - "S = R / E. S stands for either satisfaction or success or significance. R stands for reality and E stands for expectations." 38:04 - "Neil T Anderson who said it's not what you do that determines who you are. It's who you are and Jesus Christ that should determine what you do." 39:15 - "How to determine the purpose God has for your life." 39:01 - "Infinite God has chosen you as his finite creature to implement his redemptive plans for the world." 40:22 - "Every man is given a unique purpose for their life. So it's finding out what that is by tuning your heart to the heart of God. Listening to the still small voice of God in your life, leaning forward to hear it and allowing God's word to transform you and to wash off the world." 41:18 -  "The point is, guys, give your life to something that matters. Make a difference. Too many guys are like ships tied to a pier, spend all of their life polishing the brass, making sure the steering mechanism works, taking the oil off the engine, swabbing the deck, but never getting the ship away from the pier. Ships are not made to be tied to the pier. God doesn't care if your engine is oily. He doesn't care if you are a sloppy steering system. He doesn't even care if the decks are dirty. Get the ship underway and God will take you to destinations you've never been. He'll take you to horizons you've never seen. He'll have you traverse valleys you've never imagined. And God will give you a completely different view of his world. Wild at Heart Basic Event - 4 days, 3 nights. Honey Rock camp in WI    Episode Links:   https://www.heartofawarrior.org/ Dr. Bourgond's Books FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript   https://dadawesome.org/190notes

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Pablo Ceron   Pablo has been a speaker, teacher and leader of men's ministry initiatives for over 10 years. He's also the Founder and President of WILDSONS, a non-profit organization dedicated to the restoration of the hearts of God's people. Pablo was born and raised in Colombia and moved to the U.S. in 2,000, where he married his loving wife Juanita. After a long journey through the desert, and into their "promised land", they now live in Colorado with their two wild sons, Mateo (10) and Lucas (4). Pablo has also worked as a Product and Technology leader for over 20 years.   UPCOMING FATHERS FOR THE FATHERLESS 100 Mile Bike Rides   — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Link to PART 1 of this interview with Pablo Ceron: https://dadawesome.org/188/ Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad FATHERS FOR THE FATHERLESS Sponsors: Aleph Holdings, Alpha & Omega Wealth Strategies, Substance Church, River Valley Church, Chick-Fil-A Blaine 2:34 - Pablo talks through steps to healing and restoration: (1) Invite Jesus into the place in our hearts where we feel wronged, where life is unfair.... (2) Renounce the lie that life is up to me, that I will need to fight every battle because no one else will do it for me (3) Ask What is the truth? 5:09 -  "We have come to believe certain things about God and ourselves and life and then to then to bring those before God himself and to have an encounter with him where the truth is revealed to us and we get to be initiated into living life in the way that results out of that being truth." 17:41 George MacDonald says that the hardest and the gladdest thing is to cry Abba, Daddy to God from a full heart.  15:01 - Describing the meaning of "Sons" in the ministry Wild Sons.  21:50 - "When the student is ready, the teacher appears, when the Son is ready, the Father appears."  24:31 - "Father, I receive you fresh as a father, and I choose to become your son, would you father me?" 24:53 -  "And if I can go on this journey and become my father's son again. Then it must be true that my two boys are his his sons, too, and he is more interested in fathering my two boys than I am, and he knows them and has known them before the foundation of the world. So he knows their hearts. He knows what they need. He's orchestrating a journey of initiation so that they can become the men he created them to be. I play a crucial role, and my role is to ask my dad, father, father, 'would you allow me to see my son in the way that you see him? Would you allow me to see what is it at this age in this season that you're doing in his heart, in his life? And what is my role in partnering with you for that?'"  26:45 - Pablo's story of how he begins a journey of initiation from age 10-21 and God told him, "Delight in what he delights in." 28:55 -  The raising of my boys is not up to me because life is not up to me.  29:43 - "The invitation is to ask God for a revelation of what he's doing in our children's life. And for us to participate in it, knowing that the outcome is up to it's up to God, we have no control over it."   Episode Links:   Wild Sons FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team      

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Pablo Ceron   Pablo has been a speaker, teacher and leader of men's ministry initiatives for over 10 years. He's also the Founder and President of WILDSONS, a non-profit organization dedicated to the restoration of the hearts of God's people. Pablo was born and raised in Colombia and moved to the U.S. in 2,000, where he married his loving wife Juanita. After a long journey through the desert, and into their "promised land", they now live in Colorado with their two wild sons, Mateo (10) and Lucas (4). Pablo has also worked as a Product and Technology leader for over 20 years.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad FATHERS FOR THE FATHERLESS Sponsors: Aleph Holdings, Alpha & Omega Wealth Strategies, Substance Church, River Valley Church, Chick-Fil-A Blaine Prayer Team Sign Up for Aug 28th Ride  Volunteer Sign Up  Previous episode with Pablo - Episode 98 5:02 - Wild Sons  5:51 -  "That has now been almost two decades of this journey with God. And the fruit of that is that we want more people to experience what we have come to experience the goodness of God, the treasures of the kingdom, the blessing of living a life of peace and a life of adventure and freedom and joy. " 9:15 - "There is an expression of Christianity or at least the message that as men we receive is that we need to set aside all our desires and our passions and become a nice guy. Yeah, and that's not at all what I read in scripture. What I read scripture is quite the opposite. Is God inviting men into a wild adventure. " 10:21 -  "Adventure by definition implies we we are risking, we're going into into the unknown, into the frontier, into an area where we don't have the answers, where success is not guaranteed, where things could go wrong. And if God doesn't show up, we're doomed. And that's how we come alive, let's do it." 10:49 - (Talking about Wild Sons) "And part of the recovery of their heart is to recognize their need for adventure and and and and how adventure makes a man come come alive. We believe that men shouldn't be tamed, but should be given permission to be themselves and live with passion and live with freedom ." 12:16 - Wild Sons Muster  16:50 - "So for those who are willing to let it all go and go after Jesus, all in. Yeah, they're going to experience life to the fullest. Jesus promises." 27:09 - "Everything that we do is an expression of what we have come to believe at the level of the heart about God, about who we are, about who my wife is, about who my boys are, my children, about the nature of the world." 29:52 - "Ask Jesus, who have you created my child to be? Look for the true identity of the child and speak to their identity, and they will come alive." 31:42 - "When I am in my good days, when I am connected to the Father, the way that I'm learning to parent my sons is by understanding who they truly are and to speak to that." 32:31 - "Even when we are in the darkest places and in the worst of our sin, he's not coming with accusations of shame and guilt. He's coming with love to say, I know you're better than this. You may have chosen wrong, but this is not who you are. Come and act according to who I made you to be."   Episode Links:   Wild Sons FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript    

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Jon Tyson   Jon Tyson is a New York City based Pastor and Author. Originally from Adelaide Australia, Jon moved to the United States over two decades ago with a passion to seek and cultivate renewal in the Western Church. He is the author of multiple books including his latest book, The Intentional Father.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/ Make a DONATION to FATHERS FOR THE FATHERLESS   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad FATHERS FOR THE FATHERLESS Sponsors: Aleph Holdings, Alpha & Omega Wealth Strategies, Substance Church, River Valley Church  The Intentional Father book 4:29 - How the relationship with his kids has changed to building adult friendships with his kids. 5:21 - Weekly family meetings 7:33 - "Raising a son is real work, but we have to get this right, because if we don't teach our sons, the world will. If we don't teach our sons about women pornography will if we don't teach our sons about friendship, they'll live a life of loneliness. If we don't teach our sons about leadership, they'll be followers all their lives. Being a father is not about efficiency. It's about discipleship. Father is not about time management. It's about heart development." 9:37 - "A lot of good involved dads, but an intentional dad that goes that step further to consciously ask who is my kid? What at what time of history did they live in? What am I responsible to sort of give them that's going to tee them up for their future." 10:58 - Minimal manhood and skillful manhood 17:00 - Leaning into the "firsts" and making them intentional moments 17:22 - Quote from Jim Rowan - "Life is not measured by the length of our days, but by the intensity and frequency of beautiful moments ." 17:54 - The Power of Moments book  19:35 - Books/articles he had his son read when he got his first job: Your Money Counts; Total Money Makeover. ESSAY: Why Work by Dorothy Sayers 23:41- Ken Blanchard's One Minute Manager 24:05 - Exponential by Dave Ferguson 24:07 - “It's just the process of how to give away what you have and make sure it shows up in somebody else's life. It takes more time to do that. It takes a lot of time, but when you see the joy of somebody who owns something that's literally gone from your life into their life, they now have a deposit and this deposit can be given to somebody else's life. That, to me, is one of the greatest things you can experience as a dad.” 25:16 - “I think this is the key here, because so often our culture is built on charisma and charisma is like that person possesses the magical gifts that none of us have. And therefore, it produces celebrity culture and consumerism. But when you codify the gift and you can show somebody, here's what I'm doing that is working, you then impart it to them and it creates contributors in confidence rather than consumption.” 25:59 - Shop Class as Soul-craft 28:15 - "Men need a cause. A cause is bigger than a vision, more expansive than a strategy, and more long lasting than a season. It's larger than a fight." - From The Intentional Father 30:09 - On the power of a cause in men: “I basically want to infuse that a man has strength and that he should utilize it in a great fight. But the difference is it needs to be in the real world as opposed to just accomplishment. And it needs to be for the sake of others. It's never your strength. It's never to oppress others for self gratification. It is always to lift the oppressed for the sake of the other.” 30:52 - “And a part of it is to try and help young men realize, don't give you a vigor and your strength to wasted things because you have no idea how you could participate in God's great cause if you channel them for the sake of others.” 32:14 - Wisdom on relationships: “The circle of intimacy, the circle of impact in the circle of influence” 33:13 - Most important priorities in 2nd through 5th grade: (1)”maintaining the emotional bond and setting the family culture” (2) “understand the psychological development of what's happening in that age” 40:50 - “I just have a path of intentionality that sets up the odds in your favor. And again, you can't control your son's heart, but you can fight for it. And this is a plan to fight for your son's future. And I believe that when we do that, we activate the heart of God's divine favor comes through our way, the Holy Spirit, gets involved and we're not on our own. And without it, I think you're left to chance and you're left to the world.”   Episode Links:   The Intentional Father book The Primal Path Course FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Jon Tyson Instagram Twitter The Intentional Father book The Burden is Light book Beautiful Resistance book Church of the City New York

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Bob Merritt   Bob Merritt led Eagle Brook Church for 28 years. He retired in March of 2020 and lives in White Bear, MN with his wife Laurie. He joins us for this 2-Part podcast conversation on fatherhood themes ranging from leadership blindspots to fatherhood insights learned from his dog Blue.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad PART 1 of this conversation with Bob Merritt - Linked Here 2:33 - Dave Merritt speaking about his dad 5:58 - Asking his son, "Where do I screw up?" 7:24 - Jeff asks, "What have you learned about your Heavenly Father from your dog?" 9:37 - Parenting wisdom he sees in his kids 11:38 - Jesus in my weakness. Show yourself strong. It's not about me. I need you. It's a posture of kneeling, actually, as a physical posture of saying this is not about me delivering awesome. This is about me being average in desperate need.  13:03 - I was just driven by this this absolute fear and sense of responsibility that I had to say things to a congregation that were true and helpful and relevant to their lives. And if I failed at that man, what a what a failure. And I just I couldn't allow myself to do that.  16:07 - Sharing a significant parenting moment with his son. 22:01 - Quote from John Maxwell, "There's enormous magic in a tiny word, do. When we tell ourselves I'll do it, we unleash tremendous power. What is the number one catalyst for change? It's action. And if you take action, it will change your life."   23:13 - "I'll tell parents, you might not know what to do. You might say some things wrong, but do not bail. Don't walk away, don't.... ignore the issue. Pay attention to the right time and the right away, but stay in the battle. Don't just pretend there's not an issue. Don't pretend that it's going to fix itself . You might have to give it time to simmer down or whatever, but don't abdicate the responsibility of being a parent to the culture. You're the parent. God put you in that role for a reason and you might not know the exact thing to say or do.... but got to be there. You got to be present."    Episode Links:   Bob's book "Done With That"  Bob on Facebook Eagle Brook Church Final Message from Bob (March 2020) FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Bob Merritt   Bob Merritt led Eagle Brook Church for 28 years. He retired in March of 2020 and lives in White Bear, MN with his wife Laurie. He joins us for this 2-Part podcast conversation on fatherhood themes ranging from leadership blindspots to fatherhood insights learned from his dog Blue.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the dadAWESOME Nudge to becoming an intentional dad 3:44 - Bob's daughter, Meg, shares reflections on her dad. 7:54 - The impact of dads bringing their families to church 11:35 - Deuteronomy 6 - "Love the Lord your God with all your heart and with all your soul and all your strength. These commandments that I give you today are to be on your hearts [parents]. Impress these things on your kids. Talk about them when you sit at home, when you walk along the road, when you lie down, when you get up ..." 12:37 - "So the question I would have for dads: Do you know God's word well enough? Are God's commands on your heart? Because you can't teach your kids what you don't have." 14:28 - "Pain, I think can lead to passion or pain can lead to passivity." - Jeff Zaugg 16:01 - "You know, life is full of pain. We all have it. But what I would say is that God doesn't cause that pain. Right. But God can help you heal from that pain and put you on a better path if you'll be willing to allow him to do that." 17:23 -  "Pain is a signal that something's wrong when it comes to life." 21:12 - "So if I've got an anger issue, but I'm not seeing it. Will I have enough humility so. Will I have enough strength, Jeff, to ask somebody, 'Hey, will you help me see some things in my life?' See it's a person of strength who's willing to admit I've got an anger problem or I've got a spending problem. People of weakness, will never admit they have an issue." 25:19 -  "You got to be humble enough and self-aware enough to know that we all have flaws and weaknesses, that if we could just get somebody to help us look at that, you know, it could just open the world to us." 28:02 - Deuteronomy 30 - "I've set before you life and death, blessings and curses now choose life so that you and your children may live."   Episode Links:   Bob's book "Done With That"  Bob on Facebook Eagle Brook Church Final Message from Bob (March 2020) FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team Conversation Transcript        

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Troy Mangum   Troy Mangum is an author, speaker, podcaster (The Kindling Fire), and men's advocate. He is a Lumbee Indian tribal member. Troy lives in Raleigh, North Carolina with his wife Kathy. He has two sons, two daughters, and one son-in-law. A former YWAM missionary, hardcore punk singer, substance abuse counselor, busker, longboarder, exotic fruit farmer, vert skater, singer-songwriter, software engineering manager, traveling hitchhiker, and seminary dropout.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! 2:14 - Troy Magnum is author of Fatherhood Face Plants  3:50 - How to be a difference maker/fire starter. 4:29 - "There are so many men that are dads that are fatherless and and they need to know that they can become amazing, incredibly amazing fathers with God training them as father." 8:25 -  "So we all have a back story that God, if we're willing to let God take us there, he'll take your treasures out of you. That will be so deep and rich because it's a generations before you. It's not about you. It's about you inheriting something God put back way back in generations before you." 11:35 - "A lot of what the book is about is about, you know, that whole idea of getting back up and becoming the dad your kids need so much of the storyline with God is to get back up, to receive forgiveness, to seek reconciliation, to receive wholeness, to do whatever it takes to become a man that God wants you to be for your children and for your own self and marriage and et cetera. And so that is such a crucial crossing point because men so many times out of guilt and shame, they retreat and and the kids are just like, OK, I guess I guess this whole dad thing's over for you now, huh?" 13:04 - 1 Corinthians 1:27 - "But God chose the foolish things of the world to shame the wise; God chose the weak things of the world to shame the strong." - But God.... 13:29 - Telling the story of a two year separation and then reconciliation with his wife. 15:04 - "You pass on as a dad, you pass on who you are more than what you know. You can know the right things to do. You can know the scriptures that say you should do this, you can know a lot of things, but you will pass on who you are..." 19:03 - A wall or wind - Are you going to be a wall your kids need to scale to get to what God has called them to be, or are you going to be wind in their sails? 21:50 - "You pass on who you are more than what you know you want to be the whole, the most whole, healed, healthy in every sense of the word, man that you can pass on." 22:29 - Stepping into the frontier and letting God teach the skills you need. ..."are you willing and aware that this is offered to you, this training module? You look in any scripture, any man in the Bible, you can say they went to training... And a lot of that training has to do with difficulty sometimes and challenges and putting yourself in the frontiers of 'I've never been here. I've never done this. I don't have the skill.' None of that intimidates God. And if you yield yourself to God, he will put you in situations that are above your head, above your pay grade, above your talent, above your skill intentionally to help you learn skills, talents, abilities, confidence, [so he can expand your influence.]"   Episode Links:   https://thekindlingfire.com/ Troy on Instagram Troy's Podcast: Apple Pod Troy's Book - Fatherhood Faceplants  FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team Conversation Transcript    

dadAWESOME We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Jeff Zaugg   Jeff and Michelle Zaugg recently celebrated 15 years of marriage. They live in New Brighton, MN with their 4 young daughters and their Goldendoodle Boomer. After 10-years of entrepreneurial non-profit ministry leadership, Jeff served as a pastor at Substance Church in the Twin Cities for the past 7 years. In Fall 2020 Jeff took the leap and went full-time fatherhood ministry. He is the founder and lead cheerleader at dadAWESOME & FATHERS FOR THE FATHERLESS. When he's not wrestling or playing hide and seek with his daughters, you might find Jeff out for a bike ride, making a pour over coffee, sitting by a fire with his wife or challenging some friends to a game of Spikeball.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! Story of boat drifting Dark Alone Drifting Sinking Embarrassed Terrified Taking on water DRIFTING to DREAMING Definition of DRIFTING: to be carried along by currents of water or air, or by the force of circumstances... To wander aimlessly Drifting Lack of vision Lack of purpose Just trying to get through the day Numbing Stalled out Controlled by fear John 10:10 shows us the two options - DRIFTING vs. DREAMING The Thief comes to KILL, STEAL & DESTROY (Drifting) But I have come to bring ABUNDANCE… LIFE to the FULL” (Dreaming) Satan wants to kill, steal and destroy the work of God in your family, your work, your ministry, your friendships,your finances, your marriage, your parenting, and your health… The Thief (satan) wants you to be a DRIFTER. DRIFTING is a WIN for satan Remember our Bible Story? Saul was DRIFTING – he was the king and he was sitting under the pomegranate tree… (Meanwhile, Saul was taking it easy under the pomegranate tree) >> There were about six hundred men with him Jonathan was DREAMING – he was a CHANGE MAKER… As the son of the king, he had the option of relaxing like his dad. He could have played it safe… There is a Gravitational Pull towards Drifting. Our brains are wired to Avoid Pain... Limbic Cortex = Lizard Brain - ​​It's in charge of fight, flight, feeding, fear, freezing up... The lizard brain is the source of the resistance Pain is One of the Primary reasons we DRIFT. Hurts, pains and past struggles lead us to avoid risk... PAIN >> Passivity… Pain can lead to PAUSE or a Plateau in our journey of trusting God. PAIN >> Passion & Purpose DREAMER - Kids don't worry about constraints or limitations... They think with a filter of abundance and possibility Acts 2:17 “…God says, I will pour out my Spirit on all people; your sons and daughters will prophesy, your young men will see visions, your old men will dream dreams.” (Joel 2:28) Two Steps for each of us: We are going to Remember & Run Remember You Are a Child of God - it starts with your identity… You are a LOVED child of God. To live as a DREAMER, you must receive this gift and step into your identity as a Son of God… A Daughter of God Run! Throw off the Weight and Run! Hebrews 12:1 “Therefore, since we are surrounded by such a great cloud of witnesses, let us throw off everything that hinders and the sin that so easily entangles. And let us run with perseverance the race marked out for us” Pain leads to Passivity. Pain leads us to hit PAUSE on our DREAMS. The pain of our past has stolen our FREEDOM and we are looking through the little rearview mirror and over our shoulder at what should be behind us. The windshield of your life needs to be so much BIGGER than the rearview mirror Experience the healing that your Heavenly Father wants for you.   Episode Links:   YouTube Video of the entire Message - Drifting to Dreaming FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Marcus Montana   Marcus Montana, known as TRU-SERVA to his music audience, is a passionate man whose mission is to help others find true life. Growing up in a single parent home in Lacombe, LA outside of New Orleans, he was forced to raise himself while his Mom worked two jobs to provide for the family. Trapped in a materialistic society he chased after self-satisfaction, experiencing a void of true love. He was left broken after a long pursuit to fill that void, until one day.... At age 16, while TRU was at the end of his rope, drained from the emptiness of unfulfilling pleasure, he came face to face with Christ. He chose to take a spiritual step and committed to a personal relationship with Jesus. TRU felt a calling to use his talent of hip-hop to help change lives. From a young age, hip-hop influenced his style, language and attitude and it felt natural to use this genre of music and way of life to help reach people. Through his rap lyrics, he portrays a powerful message of the cross and of a positive change. He sees himself as an over comer and example of hope to many, where he stepped above the trap of being an African American male dead or in jail by age 25. A strong vision for connection is what this musician strives to accomplish each and everyday. TRU aims to make a connection between the streets and the church, saying "The walls of the church need to fall down and people need to get out of their seats and go out." He also wants to see the connection between generations, where he can speak to both kids and adults.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! 4:03 - Marcus talks about growing up without a present dad. Learning how to be a dad from his mom. 10:27 - The difficulty of seeing God as a Father without having a father. 11:00 - “When we had Malakai, that changed my whole perspective because when Malakai was born, he just laid there, didn't do nothing, and I loved him. You know, he wasn't trying to get my attention saying, hey, look at me, he just laid there. And it gave me a perspective that I don't have to do anything for the Lord to love me, you know? And so that changed my whole life…” 13:17 - “The goal isn't perfection, it's his presence.” 14:00 - “It's a thin line between using wisdom and stepping out on faith. You know, when you got other people who are responsible for you. But I've also learned that when I follow the leading of the Lord, he takes care of it.” 23:30 - “You know, Martin Luther King said rioting, rioting comes as the voice of the unheard. And, you know, if your kids are trying to share with you and you're not listening, you're too busy. They're rioting.”   Episode Links:   Spotify - Tru Serva Reverb Nation - Tru Serva Website - Transformation Records FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript   https://dadawesome.org/182notes/  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Matthew Hooper   Matthew's personal and professional pursuit of holistic growth are at the center of his life and work with others. He holds degrees in Communication from Biola University (1994) and Christian Ministry and Leadership from Talbot School of Theology (2001). Spiritual Development and Pastoral Counseling were the specialized emphases of his graduate work. Matthew also received a certificate in spiritual direction from the Archdiocesan Spirituality Center in Los Angeles. Currently, he is studying to complete a doctoral program in Higher Education Leadership at Azusa Pacific University. Over the past 17 years, Matthew has cultivated his vocation toward influencing the holistic development of emerging adults, leaders and professionals. In 2016, Matthew launched a professional consulting business (TRACK 3 Leadership Development) integrating insight from leadership, psychological, and theological perspectives for the purpose of holistic growth in individuals and groups. Recently, Matthew has excelled as a primary group facilitator for Growth Skills Foundation. He finds unique inspiration for his work in creation, music, spiritual friendship and the daily pursuit of humility as the highest virtue for human growth and spiritual flourishing. Matthew, his wife, Sheela, and their three children, Annie, Breeana and Jarren, live, work and play in Sutter Creek, CA.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! Sign up for the F4F 100 mile Ride by 1:07 - Check out episode 180 for the first half of the conversation with Matthew Hooper 2:26 - Travel tips for living in a trailer 4:12 - Everything is better as a team. Be a team in the routines of setting up and taking down. 5:00 - Recommendation: Stay at least two nights at each site. 5:28 - Expect that things will break down. 7:35 - "I would say having very consistent patterns with safety in mind, with consistency and structure in mind for your family, because there's going to be plenty of unstructured reality." 8:56 - Dad Wisdom #1: Own your role as dad. "No one can be a dad like you. No one. You're the dad in your family. So own it." 9:17 - Dad Wisdom #2 - Decide what you want to do as a dad. How do you want things to be?  10:34 - Dad Wisdom #3 - Listen to your kids 12:35 -  A Grace Disguised by Sittser 13:36 - Listening to clues in the physical body to recognize grief 14:31 - How he handled tragic loss 17:18 - You need to pace your work with sadness, you need to move towards it with intentionality. Invite other people into that and then give yourself permission to take a break.  17:56 -  Article: Navigating sadness on the journey of life    "Facing the sadness, embracing the sadness, pacing sadness." 18:35 -  "Please turn toward your heart, please. The more you're able to do that with you, the more you can do that with your wife and especially your kids. Your heart is the most important part of who you are, and that includes your deep feelings of thought willing and emotion coalescing in the heart. And so to be to be a man of heart, I think, is what I would what I would call dads to above all else."   Episode Links:   TRACK 3 Leadership Development FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Matthew Hooper   Matthew's personal and professional pursuit of holistic growth are at the center of his life and work with others. He holds degrees in Communication from Biola University (1994) and Christian Ministry and Leadership from Talbot School of Theology (2001). Spiritual Development and Pastoral Counseling were the specialized emphases of his graduate work. Matthew also received a certificate in spiritual direction from the Archdiocesan Spirituality Center in Los Angeles. Currently, he is studying to complete a doctoral program in Higher Education Leadership at Azusa Pacific University. Over the past 17 years, Matthew has cultivated his vocation toward influencing the holistic development of emerging adults, leaders and professionals. In 2016, Matthew launched a professional consulting business (TRACK 3 Leadership Development) integrating insight from leadership, psychological, and theological perspectives for the purpose of holistic growth in individuals and groups. Recently, Matthew has excelled as a primary group facilitator for Growth Skills Foundation. He finds unique inspiration for his work in creation, music, spiritual friendship and the daily pursuit of humility as the highest virtue for human growth and spiritual flourishing. Matthew, his wife, Sheela, and their three children, Annie, Breeana and Jarren, live, work and play in Sutter Creek, CA.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! Sign up for the F4F 100 mile Ride by 5:51 - Traveling with 6 people to 48 states in 4 months 7:54 - Four principles to order our thoughts and decisions 8:58 - Principle #1: Missional - Bringing Christ's kind of love and and the peace and joy and life of the kingdom, wherever we went 11:07 - Principle #2 - Being Adventurous - meaning to kind of push ourselves to do things we weren't normally doing  11:31 - Principle #3 - Positivity - "if we're going to be missional and adventurous, we need to stay positive because we know that at some point this experience is going to be stretching."  12:11 -  Principle #4 - Stretching - "Life is stretching and what we need to do is own that that is true and not live in an illusion that life is not that. So life is stretching. If we stayed here, there would be elements that would be stretching about that. If we go, that's going to be stretching and maybe even be more stretching. But the reality is life is stretching." 13:17 - "the daily pursuit of humility as the highest virtue for human growth and spiritual flourishing." 13:52 - Flourishing as a dad 13:58 - "When you tilt your mind and heart toward flourishing with your intense thinking and your intentions, you are aligning with the power of God's image in us and for Christ followers and the power of the Spirit in us and between us in terms of his his community as people." 16:41 - What is stopping dads from flourishing? Pride (lack of humility) and lack of vulnerability 17:08 - [Humility is] Seeing ourselves accurately in relation to ourselves, God and others."  20:46 - Book recommendations for flourishing, humility, ownership:  John Townsend - Hiding from Love  & Henry Cloud - Changes that Heal 22:17 - Tips and tricks to traveling as a family in a trailer   Episode Links:   TRACK 3 Leadership Development FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript    

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Mark Batterson   Mark Batterson is the lead pastor of National Community Church (NCC) in Washington, DC. One church in seven locations, NCC owns and operates Ebenezers Coffeehouse, the Miracle Theatre, and the DC Dream Center. NCC is currently developing a city block into the Capital Turnaround. This 100,000-square-foot space will include an event venue, child development center, mixed-use marketplace, and coworking space. Mark holds a doctor of ministry degree from Regent University and is the New York Times bestselling author of twenty books, including The Circle Maker, Chase the Lion, In a Pit with a Lion on a Snowy Day, and Whisper. He and his wife, Lora, have three children and live on Capitol Hill.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! Sign up for the F4F 100 mile Ride by June 27th. 3:35 -  The Circle Maker book by Mark Batterson - inspired by his father in law Bob Schmidgall 4:02 - Things Mark learned from his father-in-law - Fun surprise ideas for the family and setting boundaries with ministry. 8:21 - How Parkinson's law influences fatherhood 9:00 - So I am really challenging dads to establish boundaries. But I do want to recognize that life doesn't come in nice, neat boxes where every day or every week looks like every other day or every other week. I don't. It's really hard to challenge work and home or vocation and family. I would argue that you're never 100 percent balanced. You're always counterbalancing. 10:13 - Establishing boundaries in dad life 10:34 - Why set life goals? 10:40 -  you won't accomplish one hundred percent of the goals that you don't set. And so faith is being sure of what we hope for, Hebrews 11. And I just think that goal setting can be an expression of faith.  11:54 - One thing I learned is you can't just set the goal, like you got to reverse engineer it and figure out what are the daily habits that are going to get you to those goals. And that's where the magic happens. That's where the hard work habits. And that really is the key to going after those goals.  15:42 - Seven kind of character traits of being the man, playing the man (Episode 146) Virtue #1 Tough Love Virtue #2 Childlike Wonder Virtue #3 Will Power Virtue #4 Raw Passion Virtue #5 True Grit Virtue #6 Clear Vision Virtue #7 Moral Courage 17:04 - prayer does turn parents into prophets and you can shape the destiny of your kids with your prayer life. And they're going to be moments in your life where that's all you've got.  16:22 - "The deepest desire of my heart to be famous in my own home and it's hard to be famous in your own home and you're never home." 18:13 - Draw the circle book - 40 days of prayer 19:21 - Prayer for healing for our friend, Brian.   Episode Links:   Mark Batterson Win The Day dadAWESOME Day FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript   https://dadawesome.org/179notes/    

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Mark Batterson   Mark Batterson is the lead pastor of National Community Church (NCC) in Washington, DC. One church in seven locations, NCC owns and operates Ebenezers Coffeehouse, the Miracle Theatre, and the DC Dream Center. NCC is currently developing a city block into the Capital Turnaround. This 100,000-square-foot space will include an event venue, child development center, mixed-use marketplace, and coworking space. Mark holds a doctor of ministry degree from Regent University and is the New York Times bestselling author of twenty books, including The Circle Maker, Chase the Lion, In a Pit with a Lion on a Snowy Day, and Whisper. He and his wife, Lora, have three children and live on Capitol Hill.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list and for all dadAWESOME day updates! 1:52 - Monday, June 21st. Just write down DadAWESOME day - our launch pad to a year of becoming dadAWESOME. 2:42 - Minneapolis Fathers for the Fatherless - signup deadline is June 27th. Sign up at F4F.bike 3:49 - Mark Batterson's new book: Win the Day 5:15 - Going from "This is crazy!" to "This is awesome!" 7:10 - "Your actions are perfectly designed to achieve the results that you're getting." 7:38 - Discussing the idea of the grand gesture:  choosing to change upstream, because we know we want to see a desired change downstream  9:51 - "A grand gesture...It's just doing something that signifies, I'm making a move towards solving this problem or accomplishing this goal." 13:03 - JMD, Just manageable difficulty - if something's too easy you actually lose interest. 16:06 - Every move we make, every risk we take sets the stage for someone else. Your brave is someone else's breakthrough. 20:14 - Habit number 2, Kiss the Wave -  the obstacle is not the enemy. The obstacle is the wave. 21:18 - "I do think that it is some of the suffering that makes us appreciate the gift that life is and helps us identify with a God who suffered, who went to a cross, a God who loves us enough to go through Gethsemane. And so sometimes I need to be willing to walk through some of that suffering." 22:49 - DadAWESOME day is a declaration day. It's a decision day to make the next three hundred and sixty five days a decision towards becoming dadAWESOME.  23:47 - "If you do little things like they're big things got as a way of doing big things, like they're little things" 24:29 - "time is measured in minutes. Life is measured in moments. It's Wind the Clock habit number 6. 25:34 - "God wants to turn the hearts of the fathers towards their children. And I think when that happens, then revival happens."   Episode Links:   Mark Batterson Win The Day FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team    

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Becky Thompson   Becky Thompson is a bestselling author and the creator of the Midnight Mom Devotional community, gathering over one million moms in nightly prayer. Speaking hope into the struggle of balancing life as a wife mother, and daughter of God, Becky has become the voice of modern Christian motherhood. You can learn more about Becky's top Christian podcast, Revived Motherhood, or find more of her work by visiting BeckyThompson.com. Becky lives near Nashville with her husband, Jared, and their three children.   Dr. Mark R. Pitts   Dr. Mark R. Pitts is a graduate of the University of Tulsa Law School. He is an ordained pastor and a well-known Bible teacher in the Oklahoma City, Oklahoma, area where he lives with his wife, Susan. They have been married for 41 years and have two adult daughters and three grandchildren. In 2019, Mark created the Midnight Dad Devotional online community with his daughter, Becky Thompson, the creator of the Midnight Mom Devotional. Mark enjoys teaching Scripture and praying for dads.     FATHERS FOR THE FATHERLESS —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   Text “DAD” to 651-370-8618 to join the text list.  Monday, June 21st. Just write down DadAWESOME day 02:25 - Midnight Dad Devotional One Hundred Devotions and Prayers to Connect Dads Just Like You to the Father. 3:47 -  What if our kids inspire us to be dream chasers? 3:55 - "I love that because to me, being a dream chaser is being a God chaser. You know, I don't think that we can ever separate the two." 5:30 - Learning the Father's love from her dad. 7:14 -  We don't just have a heavenly father that parents us. We have a heavenly father who fathers us. 9:21 - "That's and that's also whole all scriptural that we are supposed to improve, if you will, improve our children, if they are supposed to be, we want them to be better than us. We don't just want them to have a better life, be more fortunate, be more prosperous. We want them to be better than us. We want them to take what we have to give them what God has breathed into them, into into us, and therefore we breathe into them and that they are going to take that and go much farther than we could have ever gone." 10:42 - "Our prayer is that men will see themselves as God sees them. We've already talked about that as they are as the warriors they are, fighting in the trenches for their families against all odds, overcoming every trial that comes their way." Quote from Midnight Dad's devotional 13:03 - "You, father, dad, are going where you're going. This is supposed to help you know, that you have a heavenly father who's going to get you there, who's going to help you accomplish that, where no other human can help you as well as your heavenly father can help you." 15:16 - "So here's the thing about Noah is that he invited his sons to build with him, that it was a family build, that Noah got the download and it required the help of his whole family to create what would be for the whole family. And so I think as dads are listening and they're like, well, this is what God has called me to. It's not just for them. It's with them that there isn't anything that God calls a parent to, that he doesn't also call the children to participate in." 16:45 - "It's the difference between that and fathering, which says I'm going to intentionally stay relational with you. I'm going to care not about what you did today, but how it made you feel. And then I'm going to invite you into my story of what God is doing in me. And the only way for a child to see the impact of what God is doing in the father is if he intentionally makes the decision to include his children in what he's going through and how he feels about it. And and I think that's what it means to build with it." 22:14 -  "it was the promise of presence, which is I am certain that I will see and experience this goodness of the Lord in the land of the living, not just know about it, not just here about it, not someday." 22:52 - You can never have more. It's the one thing you could never fully possess because there's always more to gain that the act of having more means that you have to always be reaching and going and trying. - Quoting her dad You can never achieve more, you can never actually hold more. I want to tell him that this is going to be a lifetime journey.  26:57 - "I have made spectacular failures as a as a parent. I have never made a failure as a father because my heart is pure, my heart is true. And what I want for my children is what my heavenly father wants for me."   Episode Links:   Midnight Dads Book - on Amazon Midnight Dads Webpage: https://beckythompson.com/midnight-dad-devotional/ Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript:  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Terry Esau   Terry has over 10 years in the non-profit sector, having exercised his leadership as the founder of FB4K in 2010. In addition, Terry has been instrumental in catalyzing the move from a Minnesota-only platform to the 12 US cities that FB4K currently calls home. Terry has been recognized for his societal contributions both nationally (USA Today Make A Difference award) and internationally (Guinness World Records). In his spare time, Terry is a published author and speaker on various topics, including the ‘Wellbeing of under-resourced kids in America.' In addition to his bicycle advocacy, Terry is an avid cyclist, musician and artist.   FATHERS FOR THE FATHERLESS   —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   1:50 - Text “DAD” to 651-370-8618 to join the text list.  2:16 -  Monday, June 21st. Just write down DadAWESOME day 2:53 - Free Bikes for Kids 4:44 - How to teach kids to ride a bike with a balance bike 5:58 - I kind of feel like we should live our lives with this adventure and hope and excitement. You know, it's like instead of instead of living cautiously, it's just it's just not a great way to live.  '7:18 - Sharing his dad's story of being on his own at age 16 and then serving on MN Legislature for 16 years. “He didn't let the problem of not having that education hold him back. You know, he kind of took things into his own hand and he said, I can educate myself by reading books, you know, so. So he did that. And he was you know, he was a flawed man, and a flawed father, just like I am. But you know what he he modeled? He modeled boldness and courage, and I think that's what has helped me." 12:20 -  “I look at the Holy Spirit not as a dove, but as a sharp elbow. And, you know, and our job is to keep tender ribs so that we feel the nudge of that sharp elbow.” 19:35 -  Terry's book: Surprise Me: A 30-Day Faith Experiment & Be the Surprise: Experiments in Spontaneous 25:11 - Free Bikes for Kids website - (picture of the smiling girl) 26:17 - Setting the Guinness World Record for most bikes collected in a day (5,512 bikes on year, then 10,000 the next year)   Episode Links:   Free Bikes For Kids Terry's book: Surprise Me: A 30-Day Faith Experiment & Be the Surprise: Experiments in Spontaneous Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript:  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Matt Norman   Matt Norman is President & CEO of Norman & Associates. Through Norman & Associates, he helps people think and work together more effectively. Matt's mentorship has helped Fortune 100 corporations, non-profits, and entrepreneurs change the way they engage with their employees and clients.   FATHERS FOR THE FATHERLESS —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   2:23 - New Text Message platform! Text the word "DAD" to 651-370-8618 3:09 - Save the date for June 21, 2021 - dadAWESOME day 5:48 - Creating a pathway for unlimited screen time and how that has contributed to more productive activities for the 13 yr old sons 8:42 - How marriage counseling and being a part of a mens group helped pull out of the darkness of the season of infertility. "I'm part of a men's group that, you know, has been a very important part of my life. And it's been sitting around with those men in a non fixing, non rescuing, non minimizing environment." 11:18 - Book: The Four Patterns of Healthy People  13:08 -  "I just I can't emphasize enough for myself and other people that I've journeyed with the value of finding authentic people that are willing to tell the truth and have grace and love in that." 13:50 - Three questions: (1) Where are we often stuck? Where do I shrink back? (2) What's not working for me in some of my relationships? (3) Where am I getting triggered? Where are my hot buttons? 17:41 - Pete Scazzero - The Emotionally Healthy Leader podcast  18:20 - "And even in our families where we hurt each other....Sometimes we slight each other or wound each other in in intentional ways because we're hurting ourselves and we want to, you know, make ourselves feel better by hurting someone else. But sometimes ...we're wounded. And so we're going to put on this armor and I think that armor... blocks us off from having...more intimacy with the Holy Spirit, more intimacy with our other important relationships, more effectiveness in whatever work may be, because as we work with others, we need to let others in and allow ourselves to be seen if we're going to have 'vulnerability-based trust' in the workplace."  (from Patrick Lencioni's Five Dysfunctions of a Team) 20:22 - Favorite leadership book, A Failure of Nerve by Edwin Friedman  - "The most important characteristic of leadership is to be a non anxious presence." 23:36 - Noticing that positivity can be tied to defensiveness 25:17 - What he hopes his kids say at the end of his life? 28:15 - How do we measure our day? Scoreboard and checklist or relationships and community? 31:35 - "We do all these things to rationalize, justify and excuse ourselves. And yet freedom and joy and connection lies on the other side of growth."   Episode Links:   http://MattNorman.com Four Patterns of Healthy People: How to Grow Past Your Rooted Behaviors, Discover a Deeper Connection with Others, and Reach Your Full Potential in Life and Business Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript: https://dadawesome.org/175notes/

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Tim Burt & Danny Gutierrez   Thankful for this father-in-law / son-in-law conversation about intentional fatherhood. More about Danny. More about Tim.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 16th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   1:24 - Episode 16 - Danny Gutierrez. Episode 23 - Tim Burt. Episode 69 - Renee Burt & Stephanie Gutierrez.  2:25 - "Affirmation is a powerful biblical encouragement for us to participate and to encourage one another and to lift up one another." 3:53 - Tim - "I just always exhorted her, always encouraged her. I always encouraged that she could do those things that were on her heart. And and I think Stephanie would probably say that the affirmation she's received over the years is it's been a real strength in her development." 5:24 - Tim's daughter Stephanie, "My dad not only loved me, but he liked me." 8:02 - "We get to step into being what maybe we didn't receive and that we didn't have modeled for us." 12:28 - Tim talks about the benefit of listening and drawing out connection from his kids and how he wishes he would have done that more. 15:45 - Advocating for a special needs child 19:24 - The multiplication effect when you're learning for others. 20:22 - Tim - "Pay attention to how God uses you and just go with that." 21:19 - Tim - "People are all good at different things, and it's just not something you're good at. It's something that God can take to another level." 24:51 - Tim - "If you will just make a commitment to do something, you're going to find out what you shouldn't be doing and what you're absolutely not good or gifted at. And you're going to discover the things that you are gifted and you're good at. And the discovery is part of the whole thing. But it doesn't happen without taking some kind of a commitment, and as a pastor, I'm going to say God wants you to commit to serve in the local church because it's not for the church, it's for you. It's all about him developing you." 26:50 - Danny - "Be intentional with your interest, because I think right now we live in a world where everything's asking for it and we give it away so easily... And I think if when we put interest in our kids and what they're interested in and what their hopes and dreams are and what some of their, what they like to do and what's going through their little minds or what season of life they're in, when we give intentional interest to that, I think it becomes molding us into the kind of dads they need us to be in those particular seasons. 28:17 - Tim - "And if you will just be very conscientious about asking God for help all day long, every day, you'll constantly be taking off some of the burdens of fear or inadequacy or anything else that you're facing in your life. And all I would say is just try to remember some of the things you asked because he answers a whole lot more things than you're paying attention to. And if you'd pay attention to him, you'd know how much he works in your life, which is the proof of how much he loves you. And he would be so much more real to you." Episode Links:   Danny Tim Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript:  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Pete Stanley   Pete & his wife Kaycee are the founders of The Reel Hope Project. He believes family is one of the most powerful forces on the planet. Kids need family, and Pete considers it an honor to play even a small role in helping to make that happen. Plus, he's married to Kaycee (Reel Hope's executive director), so ignoring The Reel Hope Project would be like trying to avoid candy if you lived with Willy Wonka. Pete speaks on behalf of The Reel Hope Project each week at events and faith communities, sharing about Minnesota's waiting kids CREATING VIDEOS OF MINNESOTA KIDS WHO ARE WAITING TO BE ADOPTED... In Minnesota, there are 1,000 kids awaiting adoption into a forever family. They work with counties and adoption agencies to mobilize the faith community to bring foster kids into forever families.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   1:02 - May 14th - Early Registration deadline for F4F Minneapolis ($25 discount). Sign up at F4F.bike 1:33 -  Reel Hope Project  4:24 -  "It seems like the moments that I really get excited about in terms of being a dad come after I've had to give a hard word to my son." 6:00 - "Family is one of the most powerful forces on the planet." 06:15 -  "And so I would I would distill that further and say that you learned it around the dinner table and you can't have a dinner table without family, without community. And I think that's how you learn how to have disagreements, how you learn how to have arguments, how to learn how to take turns, to talk about your day and interact with other people. And and so I think that that is like that is sort of the the the the foundation for for all of these things that we're trying to build, like all these beautiful things that we're trying to build in the world, take root in healthy whole families.  7:29 - The importance of having a team of people around you when entering the adoptive world. 9:18 - How to handle the friction that comes into marriage when adding kids, or adoptive kids to the family. 11:23 - Speaking highly of his wife 13:17 - Why men/dads still need to grow up 13:57 -  "The father wounds that you're going to inflict on your children are already healed. Like God is, God has worked that out. And so that sort of gives me, that gave me, that gives us permission to dive in, head first to the relationship that we have with our kids." 19:13 - Recommendation: setting up therapy for your kids, benefits of therapy as a dad. 22:54 - What is the Real Hope Project? Making super high quality videos of kids in MN who are waiting to be adopted. A thousand kids have no family and need to be adopted. 25:29 - Praying about adoption while starting an adoption ministry. 28:00 - Misconceptions about adoption. (1) It can be expensive. (it actually can be virtually free.) 28:33 - "The kids don't get put into foster care because they're bad. They're in foster care because someone important in their life didn't do something that they needed to do for them." 31:00 - thereelhopeproject.org  31:52 - Finally Home - Fort Collins, Colorado 33:30 - Book recommendation: The Connected Child by Karen Pervis    Episode Links:   thereelhopeproject.org Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript:   https://dadawesome.org/173notes/ ‎

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Adam Griffin   Adam Griffin is the Lead Pastor of Eastside Community Church in Dallas, Texas. Adam is the cohost of the Culture Matters Podcast and the coauthor of the book Family Discipleship. In 2018, Adam completed his Doctor of Educational Ministry Degree at The Southern Baptist Theological Seminary where he designed a strategy for churches to address racial reconciliation in Dallas. Adam lives in Lake Highlands with his wife Chelsea and their three sons Oscar, Gus, and Theodore.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:    2:21 - Join the momAWESOME Challenge - Send a text with the word "MOM" to 651-370-8618 3:03 - May 14th - Early Registration deadline for F4F Minneapolis. Sign up at F4F.bike  Article: "Raising Kids the World Will Hate."  Adam Griffin:  "I'm seeing some of the fruit of the labor we've put into our kids to the point now where for us family discipleship, which is really what we're talking about, has become so normal that if I remove myself from a situation, my kids can lead themselves through it." 6:58 - Family discipleship at bedtime 7:29 - "I feel especially passionate and saying I don't want my oldest son to be the only one who's got leadership experience in this family." 7:53 -I'm trying to, like you said, build in not only them to be receivers, but then to be leaders and already I'm thinking about them as fathers. I'm thinking about them as husbands. I'm not just thinking about them as my kids with some obligation I have to mention Jesus as we put them to bed. But I'm trying to grow men." 9:22 - Choosing scriptures for his kids. "Be on the alert, stand firm in the faith, act like a man and be strong and let everything you do be done in love.".... "Be strong, show yourself a man, keep the charge of the Lord, your God, walk in his ways and statutes." ...."He's told you, O man, what's good and what does the Lord require of you but to do justice, love, kindness and walk humbly with your God." 11:50 -  "I believe is that there's a countercultural nature to the way Christians are called to parent, to lead, to live, and that's that we are not of the world, even though we're in the world, it's that we will be hated because Jesus is hated." 12:20 - I want them to stand by what they believe, regardless of what the world would say about it or how small the minority of people is who believe that." 13:05 - "Do Griffins follow the crowd? And my sons will say that to me only if the crowd is following Jesus." 14:12 - Book: Family Discipleship and the idea of being "dads who take the lead."  16:22 - "If when you think about leading your wife or you think about leading your kids, you're thinking about how can I lay down the gifts God has given me of strength or wisdom or insight or of time in order to meet the needs of those people that the Lord has me living with right now? And so leadership, to me, it has to be servant-hearted and it has to be service-oriented because that's the way we see Jesus lead and that's what he's called us to do." 17:22 - Family discipleship - Critically important, but mostly ordinary. 18:38 -  "So what they need from you, dads, is a demonstration of what it looks like to be an imperfect person who follows a perfect God. They don't need you to be their savior. They have that in Jesus Christ. But what they what you can serve is an example of like, well, here's how dad makes mistakes and repents. Here's how dad tries and fails. Here's how dad tries and succeeds." 20:45 - Modeling, Time, Moments, Milestones - the framework for discipleship 22:32 - "And it's in those significant times where it's going to be memorable that we have the opportunity to point to God's faithfulness, no matter what the circumstances, and to create something bigger." 23:55 - I really believe in the concept of family discipleship that we help you walk through. What is modeling look like in your house? When are you going to do family discipleship time? What language can you use in your household around moments? And then what's your plan for milestones? What do you want to build towards or when you want to be doing? 27:51 - Quote from Charles Spurgeon, "we sow, we reap... Let us expect our children to know the Lord. Let us from the beginning, mingle the name of Jesus with their ABCs."  - making family discipleship as important as education. 30:43 - Quote from Charles Spurgeon - "Aspire, dear brethren, to shine widely as a candle set upon a candle stick gives light to all that are in the house. First see to it that you are truly saved yourselves. Then cry out, cry to the Lord for your own kith and kin and labor for them until they are brought to the redeemers feet and then let your light shine throughout the neighborhoods where you dwell. It is. It is a poor lamp which cannot be seen outside its own glass." 34:59 - Deut 6 - Be diligent in impressing these things to our children. Deut 4 - Be diligent in the care of our souls.   Episode Links:   Adam Griffin - https://www.eastsidedallas.org/adam Book - Family Discipleship: Leading Your Home through Time, Moments, and Milestones Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript: 

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Nick Hall   Nick Hall is the visionary of Together, author of the book Reset, and the Founder and Chief Communicator for Pulse. As an evangelistic voice to this generation, Nick Hall has shared the Gospel at hundreds of events to more than five million people and is regularly featured as a speaker for pastors gatherings, student conferences, training events, and festivals around the world. Nick is also the President and CEO of The Table Coalition and sits on the board of the National Association of Evangelicals. He has been featured on major media outlets including the Huffington Post, USA Today, Fox News, US News & World Report, Washington Post, Christianity Today, Moody Radio, Christian Broadcasting Network, Trinity Broadcast Network, and The Christian Post. Nick is married to his best friend, Tiffany, and they are proud parents of Truett, Ruby, and Jude. They live in Minneapolis, MN. Nick has a Bachelor's Degree in Business Administration from NDSU and a Master's in Leadership and Christian Thought from Bethel Seminary in St. Paul, MN.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   2:21 - Join the momAWESOME Challenge - Daily texts for 9 days leading up to Mother's day - Text "mom" to 651-370-8618. 3:13 - Pulse https://pulse.org/ - Exists to make Jesus known 6:47 -  On looking for young evangelists to mentor. "I've lost a lot of mentors and heroes. And then in that, at some point you kind of open your eyes. You're like, wait, I'm not just the one that's supposed to receive anymore. Like, man who who is coming after me." 10:25 -  "You know, like I have told people all around the world about how God loves you and that it's this free gift. But I have consistently tried to earn it" 10:39 - "I think it's true for a lot of us as dads, or just people trying to make it, is like...the starting blocks in track. And I think a lot of people's starting blocks are guilt and shame. And you're pushing off to prove others wrong or you're pushing off to show people that you are enough. But I think it's like learning to rest in the fact that I'm enough, because my Father says I am. I'm enough because of what Jesus did for me, I am the beloved son of God." 12:39 - Description of prayer from the book The Life of the Beloved - "Prayer is being quiet enough to hear the good things that God says about you." 16:55 - What does it look like to live on mission? Why is it important for dads to live with deep conviction? 18:23 - "The mission that I'm on is are we living our life to point people to Jesus or does our life look like everybody else's?" 19:55 -  "But I do just think that there's this exciting opportunity that we have to change our neighborhoods to change the sports teams our kids are on, you know, to claim the ground beneath our feet and to welcome our family into that mission as well."  20:22 - Pulse Resources https://pulse.org/ 22:48 - Learning from his dad 27:25 - "And I just think, like, there's always somebody who's doing what you want to be doing or somebody who you would like to look more like. Right? And so for me, I just think, one of the secrets of life is... getting around people who are a step ahead... Who are further down the road... who can help you see your blind spots." 32:00 - "I think the biggest thing that we all need individually is just like am I personally being connected to the word of God, the spirit of God, the people of God. Because if I don't have an inflow, if I don't have an inflow from truth from God, if I don't have an inflow of truth from my community, and if I don't have an inflow of somebody kind of helping me see through this, personally, I feel really lost. Right? And so those are just be three things that that I think are super crucial lifelines." 32:36 - "I think the the greatest challenge of being a parent is realizing and letting God parent you. And, you know, the best way to love your kids is to realize that you're the beloved son of God."   Episode Links:   https://pulse.org/ Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript: https://dadawesome.org/171notes/ ‎

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Dr. Joe Sevlie   Dr. Joseph H. Sevlie, D.C., FASA, is a 1983 graduate of Northwestern College of Chiropractic and founder and director of the Center for Natural HealthCare, PLLC, in Red Wing, MN. He is a full-time practicing licensed chiropractic physician, a certified acupuncturist, and functional medicine practitioner and nutritionist. His primary goal is to see his patients dramatically improve their health, energy, vitality, and joy for living, using chiropractic services paired with functional, revitalizing natural medicine. Dr. Sevlie is married to his wife, Tami, and has seven children and fifteen grandchildren.   Tyler Sevlie   Tyler and his wife Vanessa live in Minneapolis with their 5 (soon to be 6) kids. Tyler works on a Financial Planning team by day and is a superhero dad by night. He's also famous in the coffee review, craftsmanship and tips field.  Tyler was instrumental in the launch and growth of the FATHERS FOR THE FATHERLESS 100-mile bike ride and he joined dadAWESOME back in November of 2018 on Episode 44 (Spiritual Slavery to Sonship).   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   5:41 - Facilitating a heart connect with our kids 8:18 - Sharing Biblical values in the context of making up a story 16:50 -  "Don't live in your own understanding it, if you live in your own understanding, you're going to miss it. If you live it in God's understanding, through the power of the Holy Spirit, in his presence, he will make everything clear and he'll provide and he'll do his gig" 17:50 -  Spiritual Slavery to Spiritual Sonship by Jack Frost   18:40 - "It was we tell the people about Jesus because that doing that so telling others about Jesus is statistically one of the greatest predictors of your own kids loving Jesus."  27:13 - Primal Path curriculum.  30:00 - Letters from Dad ministry  33:20 - John Eldridge Wild at Heart 33:20 - John Eldridge Fathered By God 33:20 -  Stasi Eldridge - Captivating 33:39 - "what's so crucial for a daughter is his dad needs to tell them how beautiful they are. If they understand they're beautiful in dad's eyes, they have their self-image and who they are. They can then received love from their heavenly father. They can really receive love from their dad. They need to hear that from dad daily." 35:56 - "staying connected heart wise and and making sure they know when you screw up, you know that and and you make it right between you and them, I don't think he can ever go wrong. So cheering him on, letting your daughter know she's beautiful. If you screw up saying, look, I'm really sorry, it's good, I'm going to do better, I want to do better, and with Jesus help, I'll do better. And and always bringing Jesus back into the equation with your kids because they know that he is the source from whom dad gets everything from." 36:53 - "Jesus Christ is the kindest person I've ever met. Yeah. That's so true. I've seen that in your life. just like you enjoy how kind he is. And you regularly like a reconnect, like you go back to him and spend time with him and you get refreshed with that kindness."   Episode Links:   Dr Joe Sevlie's Website Tyler's Coffee Instagram Account Spiritual Slavery to Spiritual Sonship by Jack Frost     Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team Conversation Transcript: https://dadawesome.org/170notes/

Il fut un temps, très bref, ou les musiciens qui avaient participé à l'enregistrement d'un album étaient crédités quelque part sur la jaquette. Signe des temps, plus de disques, plus de pochettes : les musiciens sont retournés à l'anonymat. Johan s'est voué à réparer cette injustice. Vous avez eu droit à Steve Jordan, Calep Hamphrey, Hal Blaine, Bernard Purdie ... Dans la famille batterie, voici James Gadson dont la carrière a commencé en 1968. Depuis vous l'avez entendu aux côtés de Marvin Gaye, Barbra Streisand, Herbie Hancock, Lalo Schifrin, Norah Jones ou Albert King pour ne citer qu'eux. James Gadson, Express Yourself, cette semaine dans Bon Temps Rouler…      Playlist :   Nobody Wants A Loser - Albert King - Truckload Of Lovin' Who Is He (And What Is He to You?) - Bill Withers - Lean on Me: The Best of Bill Withers   Express Yourself - Charles Wright, The Watts 103rd. Street Rhythm Band - Express Yourself: The Best Of Charles Wright And The Watts 103rd Street Rhythm Band C'mon in My Kitchen - Kara Grainger - Shiver & Sigh   I've Always Been Lonely - B.B. King - Take It Home In My Girlish Days (Album Version) - Phoebe Snow - It Looks Like Snow   Give It Up - Amos Lee - Amos Lee Cheatin' On Me - BJ Sharp - Never Felt No Blues   I'll Get Along - Michael Kiwanuka - Home Again (Deluxe Version) I Think About You - Patti LaBelle - Love Songs   Cruisin' - Smokey Robinson - Where There's Smoke... It's All Right - Aaron Neville - Bring It On Home...The Soul Classics   Lean on Me (Live at Carnegie Hall, New York, NY - October 1972) - Bill Withers - Bill Withers Live At Carnegie HallHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Michael Jr.   Known as a comedic thought leader, Michael Jr. brings laughter and encouragement to audiences all over the world. Using comedy and dynamic storytelling, he inspires audiences to discover and activate their purpose. This unique skill set has landed him on stages like The Tonight Show on NBC, Tedx Talks, and Jimmy Kimmel Live. His mission to make laughter commonplace in uncommon places means that he also seeks opportunities to share his gifts with those in homeless shelters and prisons. You can find him in Sony Pictures' feature film War Room, as well as starring roles in Selfie Dad, Laughing On Purpose and More Than Funny.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   4:45 -  "I have five kids and I have...five extra kids. And what I mean by that is there's a there's being a dad and there's also being a dad like one, because around us there's always some kids who don't have a father figure in their life at all." 5:55 - "The greatest name I've ever been called is DAD...I just I think there's a lot of guys who are missing out on some great opportunities in life... the cool part is, is even where our dads lack, God completely picks up plus some..." 7:39 - Funny How Life Works book 9:36 - "There's going to be times where things seem rough. You don't know what to do as a dad. You're struggling. But just the fact that you're there, just the fact that you're present is awesome. But in those times when things are getting hard, the key thing to do is to be still and listen to the Father's voice because he is talking to you. And what he wants you to know is that he's right here. He loves you. All you have to do is open your eyes." 11:17 - "Correct but don't reject." 12:43 - "Telling his kids after discipline:  "I just do not like disciplining you. But it is a requirement. It's what I'm called to do. Otherwise you won't be prepared for when life tries to discipline you." 16:14- Addressing the "hecklers" in our lives - often our own negative self-talk.  "You have to address the heckler and use scripture to chase the heckler away." 17:05 - On stepping out of being amatuer as a dad. The oldest dad in the world gave you this assignment, which means you must be ready for it....He is the greatest dad ever. And he looked at you and said, you know what? You're ready. 17:43 - The impact of his dad apologizing to him. "I remember him apologizing to me and I and I don't know if he was human before that. Like that's when he was most human when he apologized... " 18:11 - Tips for having important, hard conversations with your kids. 20:12 - Quote from Funny How Life Works: "Looking back, I now realize that many of the things I resented or found annoying about my earthly father are the very things that allowed me to open the gifts my Heavenly Father had deposited in me.  23:46 - "So you're going to make some sort of mistakes. But fellas, I want you to know for sure you are absolutely dadAWESOME, because I got an awesome dad and I know I'm going to be an awesome dad because I'm a give it my all. Even if we're going the wrong way, I'm going the wrong way all the way, because I'm doing it because I love my kids and they're going to know that." 24:55 - The way comedy works is there's a set up and there's a punchline. Right? The setup is when a comedian makes you think in one direction. What a punch line is when you change that direction in a way you're not expecting. The results are revelation, fulfillment and joy expressed through laughter. In life, it's the same way. 33:49 - So by all means, look for those opportunities to speak into somebody's life. That base that you got. You got that base for a reason. Some kids need to hear that coming from five feet above them, or a foot above them. Or eye to eye contact or maybe even looking up to them. Just speak into their life.   Episode Links:   https://michaeljr.com/michaeljr Funny How Life Works Book Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Conversation Transcript https://dadawesome.org/169notes/

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Dr. Peter Larson   Peter J. Larson, Ph.D. is a licensed clinical psychologist, published author, and leader in assessment development. He is the former President of Life Innovations and the co-developer of several internationally used assessment tools, including PREPARE/ENRICH, MCODE, and TruMotivate. He is also an experienced couples therapist and the former Director of Research and Clinical Services for the Smalley Relationship Center. Peter has been married to Heather Larson for 25 years and has three children ages 17, 18 and 20. Peter and Heather regularly teach, write, and coach premarital couples together.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   4:42 - Tips for dads taking their 11 to 13 yr old son or daughter on an intentional trip: 5:57 - "A big topic of the conversation is how do you show up, and not be conformed to just what everyone else is thinking and doing?" 6:11 - How do you prepare your younger child to WANT to go on a trip when they are 13? 10:48 - "You can't just start strong or launch them. Well, you gotta finish strong too. And because that does impact you. And that's like probably one of the few pain points, when I think about my dad - like, man, he was such a rockstar. I wish he would have finished a little stronger in terms of his, just his modeling of lifestyle." 14:33 - Peter's take on cheering on his athletic son - "There's being proud of your kid, and then there's being like letting your own identity creep into it.....So, you know, keeping your priorities in check, and making sure that's not the only focus of life.  You know, life's a whole lot more, especially than something like that." 16:12 - Prepare Enrich [https://www.prepare-enrich.com/] - marriage and premarital assessments for couples. 17:00 - Gloo [https://www.gloo.us/] - assessments and developing tools to serve churches 19:34 - On encouraging strengths in our kids: "...Starting to pay attention to what is it that they naturally do and that they love, and realizing there's some motivation there that is going to serve them throughout their life. And how do we unleash that - fan those flames. And what's fun is it's going to be different than you, you know, they're their own unique person." 19:52 - True Motivate tool [https://trumotivate.com/] 23:02 - "You can't make them do anything they don't want to do. And now on the flip side.... actually you do have influence though. And influence is wonderful because it's like a continuum. And so your question, your challenge as a dad, as a parent, is to think about how can I maximize my influence while knowing I don't have control." 24:22 - How do you influence your kids? 5 ways... 25:21 - (1) Light up when your kid walks in the room. 27:30 - "[My kids are] copying the things I do, even when they don't make sense, you know, when they're irrational." 29:57 - Why to make date nights a priority and what that models for our kids. 31:21 - (2) Setting up routines as a family 32:18 - (3) Making church a priority 33:55 - (4) The importance of outsourcing influence to other positive influences and letting go of control. 36:47 - (5) Don't get on the roller coaster of emotion with our kids 39:54 - "Great parents are often very willing to share a little bit of gold. And so don't hesitate to look for those moments where you can glean a little of that and mine some gold, because those things have informed our last 20 years of parenting and has been awesome."   Episode Links:   www.gloo.us www.prepare-enrich.com Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team Full Transcript: https://dadawesome.org/168notes/ ‎

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   David Horsager   David Horsager is the CEO of Trust Edge Leadership Institute, national bestselling author of The Trust Edge and The Daily Edge, inventor of the Enterprise Trust Index™, and director of one of the nation's foremost trust studies: The Trust Outlook™. His work has been featured in prominent publications such as Fast Company, Forbes, The Huffington Post and The Wall Street Journal. David has delivered life-changing presentations on six continents, with audiences ranging everywhere from FedEx, Toyota and global governments to the New York Yankees and the Department of Homeland Security. Get free resources and more at www.DavidHorsager.com, www.TrustEdge.com, and www.TrustEdgeCoaching.com   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes: 1:53 - LINK TO DAVID's 1st time on dadAWESOME - https://dadawesome.org/138/  3:55 - Praxis Labs Resources https://www.praxislabs.org/ 4:45 - New insights as a dad 5:17 - "See the good, say the good, share the good." 9:24 - David's 2020 reflection video - "15 Things I Learned In 2020 That I Can Use Forever" - 10:01 - "Reflection allows space for God to speak to us." 12:01 - Rhythms of rest and pause 13:41 - Pacem in Terris - Hermitage retreat center 17:33 - SEEDS - Sleep, Exercise, Eat right, Drink water, Source of strength 20:24 - "People that are leading well, actually have a source of strength beyond themselves. And they're better at work. If people are getting all their life from work, they're worse at work." 21:16 - "Inputs, always lead to outputs" 22:13 - Phil 4:8 - Whatever is true, whatever is noble, whatever is right, whatever is pure, whatever is lovely, whatever is admirable, whatever is excellent or praiseworthy, think about such things.' 24:28 - The Circle Maker by Mark Batterson  26:06 - Discussing inputs as a dad that lead to great outputs 26:07 - "Quantity time builds quality time." 28:08 - Pathway to Purity  31:04 - David's new book: The Trusted Leader 33:22 - Trust Edge - David's bestselling book. 34:32 - Faith-based module about what God's saying about trust. - Email the team for this resource. Anne (at) trustedge (dot) com 34:58 - Trustedleaderbook.com/dadAWESOME 35:41 - How dads can be difference makers. 36:09 - Making a list of 5 DMA's (difference-making actions) for each day. Ask: What are the difference-making actions today to drive our mission, to do what we're supposed to be called to do today? What are the most important things? 37:52 - One thing that consistently comes to mind is consistency, which is the final pillar of the Trust Edge Framework. And...as a dad or a leader, little things done consistently make the biggest difference, not the big things you thought... Little things done consistently make the biggest difference.   Episode Links:   David's new book: The Trusted Leader www.DavidHorsager.com Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Full Transcript:   https://dadawesome.org/167notes/

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Rob Champion   Rob Champion is the campus pastor at People's Church in Oklahoma City, OK. He's been married for 25 years to his wife Nickie and they have a 20-yr old daughter and 18 yr-old son.   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   3:20 - Describing the transition from younger years to high school "coaching mode" and friendship beyond. 5:32 - Coaching out of relationship 7:42 - What he saw from his dad - what areas he admired, and what he chose to do differently in his family. 12:42 - Thoughts on brotherhood - Quote from Ecclesiastes - "One can be defeated, but two can stand back to back and conquer, and the triple braided cord is not easily broken." 15:26 - Killing Kryptonite by John Bevere 18:22 - Weakness as a dad - struggling with anger. 20:53 - How he recognized the need for a change. Recommended book: Leadership Pain 22:48 - "I've learned that in our journey, don't be afraid of the pain, the pain that you experience is God's trying to show you and grow you through your pain. So embrace it and be willing to go on the journey. God will lead you." 23:49 - "Anything you're not liking in how you're behaving is tied to a root in your life that God is trying to uproot." 24:42 - "Guard your heart for out of it flows the wellspring of life, everything comes out of it." 27:28 - Rob's Brotherhood Groups https://www.facebook.com/groups/menszoomgroup/ 30:45 - Practical mentoring tips: "Seek first to understand your kid, seek first to understand your wife, seek first to understand anyone..." 34:01 - "And just because you may not have the skills that another brother may have or, the abilities that someone else may have, understand that you, your value is not based off of what you do. It's based off of whose you are, you belong to the Father and your value is rooted in that. Stand confident in that understand you have something to offer your kids. You have something to offer your spouse. You have something to offer your church. You have something to offer this world and walk in your gifts and let other people do the things that you're not so gifted in and celebrate them in it as well."   Episode Links:   Pastor Rob's Brotherhood Zoom Group https://www.facebook.com/groups/menszoomgroup/ People's Church https://peoples.church/ Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Full Transcript:   https://dadawesome.org/166notes/

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Dean Stinchfield   Dean and his wife Lisa have 2 daughters and a son-in-law and they live in the west metro of the Twin Cities. He leads the ministry Men of The Kingdom and his personal mission is to glorify God by participating in the advancement of his Kingdom by equipping and encouraging the next generation of moral leaders in the church. (Matthew 6:33, 1 Corinthians 10:31, 2 Timothy 2:2, 1 Peter 5:2-4, Matthew 28:19-20, Hebrews 10:24-25)   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes:   PART 1 of this Dean Stinchfield conversation: https://dadawesome.org/164/   1:42 - Men of the Kingdom https://www.menofthekingdom.com/ 2:08 - Chuck Colson Centurion program https://www.breakpoint.org/join-the-centurions/ 2:37 - Being told by Chuck Colson, "If you don't think you're doing something for the Lord right now, you're missing it. As a Christian there's no such thing as retirement. There's just repurposement." 3:54 - "The biblical model of the church is everybody has been given a gift by the Holy spirit and that gift isn't to edify them, it's to serve the church and equip and encourage other people." 4:33 - Describing Men of the Kingdom - how he determined "the great work" he is meant to do in life. 6:29 - GUIDE FOR HELPING DADS FIND PERSONAL MISSION STATEMENT https://www.menofthekingdom.com/resources-curriculum/ 7:03 - A personal mission statement answers the questions -  What are the unique gifts that you've been given? What are the burdens on your heart? Where do we feel completely alive? 7:28 - Three eternal questions: Who's your audience? What timeframe are you living your life? What treasures are you going after? 8:52 - Reading the Beatitudes with a Dad filter (Matt 5:3-12) 16:05 - Being asked to play a dad role for his friend who passed away tragically 18:46 - Living from the personal mission statement 21:28 - Final thoughts from Dean: Have courage. Pray dangerous prayers. What kind of mission do I have for my life? Take risks. Fail often and early. Don't be a critic. Be an encourager. 23:28 - Man in the Arena - "It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood; who strives valiantly; who errs, who comes short again and again, because there is no effort without error and shortcoming; but who does actually strive to do the deeds; who knows great enthusiasms, the great devotions; who spends himself in a worthy cause; who at the best knows in the end the triumph of high achievement, and who at the worst, if he fails, at least fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat." Theodore Roosevelt     Conversation Links:   https://www.menofthekingdom.com/ Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   Dean Stinchfield Dean and his wife Lisa have 2 daughters and a son-in-law and they live in the west metro of the Twin Cities. He leads the ministry Men of The Kingdom and his personal mission is to glorify God by participating in the advancement of his Kingdom by equipping and encouraging the next generation of moral leaders in the church. (Matthew 6:33, 1 Corinthians 10:31, 2 Timothy 2:2, 1 Peter 5:2-4, Matthew 28:19-20, Hebrews 10:24-25) "It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood; who strives valiantly; who errs, who comes short again and again, because there is no effort without error and shortcoming; but who does actually strive to do the deeds; who knows great enthusiasms, the great devotions; who spends himself in a worthy cause; who at the best knows in the end the triumph of high achievement, and who at the worst, if he fails, at least fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat." Theodore Roosevelt   FATHERS FOR THE FATHERLESS   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. —MINNEAPOLIS, MN — August 28th, 2021 — DENVER, CO — September 18th, 2021 — PHILADELPHIA, PA — October 2nd, 2021 — NEW YORK, NY — October 9th, 2021 — PHOENIX, AZ — November 20th, 2021 Register Here: https://f4f.bike/   Show Notes: 3:20 - Quote from Edmund Burke, "The only thing necessary for the triumph of evil is for good men to do nothing." 4:47 - In response to this quote from Edmund Burke - pressing into the ownership of the space God has put in front of us. "This is my space and God's given us a space to....we got to have ownership of that and step forward. And we have kingdom power, so we should be stepping forward and utilizing that kingdom power." 5:04 - "The man in the arena" -  speech by Teddy Roosevelt - every dad is a man in the arena. 5:42 - Beliefs passed down from his parents - that the future is good and we have a good Heavenly Father. Drawing out the best in him and projecting that into the future. 6:33 - "That which we focus on tends to multiply....find the best parts of your spouse or the best parts of your kid and focus on those because they'll tend to expand. Either in your vision but also in your life." 8:18 -  Sharing with his girls: "I will always love you. I will always be your dad. Jesus will always love you. We will always be friends." 10:08 - The emotional bank account - word bank account inside our kids. Affirmations are deposits and criticism is a withdrawal. 11:46 - Why repetition is important when it comes to speaking life. 12:26 - Setting up a foundation to be able to recognize when a relationship is right, this is what it feels like. 14:02 - Sharing a not-so-awesome dad moment. 15:12 - The best thing I can do for my girls is to love my wife and respect my wife and honor her, no matter what our relationship is doing, I'm called to sacrifice and love my wife, period. 15:08- Speck management vs Log work - focusing on the small flaws or failures of other people, focus on yourself. 22:10 - "CS Lewis talked about the God-like patchwork. He said, the revealed word is like, we're walking in this dense wooded forest. And every once in a while, the sunlight breaks through the canopy. And I think God's word is like that." 24:34 - On why the local church is so important. "AW Tozer talks about in The Pursuit of God , that we should have an authentic relationship based on an experience, not hearsay, with God the Father, God the son and God the Holy spirit. And the local church gives us a chance to do that." 25:33 - Why he volunteered in the kids ministry.   Conversation Links:   https://www.menofthekingdom.com/ Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team   Full Transcript:   https://dadawesome.org/164notes/  

dadAWESOME   We're on a mission to add LIFE to the dad life. We're passionate about helping dads live fully alive as they lead their kids to God's awesomeness.  | YouTube |  Instagram | Facebook | Twitter   FATHERS FOR THE FATHERLESS 2021 Announcement:   Registration is NOW OPEN for the FATHERS FOR THE FATHERLESS 100-mile bike rides. Click HERE TO SIGN UP for one of these cities: --MINNEAPOLIS, MN -- August 28th, 2021 -- DENVER, CO -- September 18th, 2021 -- PHILADELPHIA, PA -- October 2nd, 2021 -- NEW YORK, NY -- October 9th, 2021 -- PHOENIX, AZ -- November 20th, 2021 Goal - To raise $1,000,000 for the fatherless.   Four  dadNOTES from the first Two Months of 2021:   2:24 - Are we ready emotionally to handle the journey that our  kids are on? We need to bring our emotional strength to their situation. 2:32 - Episode 156 - Pastor Peter Haas (Part - 2 of 3)  “I've noticed that my kids don't need me to have all the answers, but they do need me to be emotionally capable of helping them find God in the midst of that. And, I've noticed that the greatest disciplers aren't the ones with all the Bible answers. They're the ones that are just willing to be present and go on a journey with you.” 3:26 - Are we opening doors, are we hosting an attach on the hearts of our kids? 3:33 - Episode 159 | Zach Neese - Story of Lot and Sodom and Gomorrah. "One of the ways that Lot, a righteous man, one of the ways he failed was in guarding the gateways of his kids' hearts from the culture that they had moved into. The culture influenced them, they didn't influence the culture....we have more access points in our lives today than at any other point in history and we have less training in how to guard those access points than in any other time in history." 5:33 - Episode 161 - Efrem Smith - “Now my dad and I talk and we can't have a phone conversation without my dad saying, ‘I love you. I'm proud of you. I love you'….and even at 52 years old, hearing my 77 year old dad say that to me even now is so empowering [and] so transformative. And so, I think for me, one thing I would say is dads need to not be afraid, not be hesitant in a healthy way of being vulnerable in front of your kids, because what that shows is that you're not stronger than the creator of the universe...we do a disservice to our kids if we lead them to believe that we can live well without God.” 7:21 - Episode 160 - Phil Comer  - The concept of "the box" from the book Raising Passionate Jesus Followers [NEED LINK] – Jesus is the foundation, then there is discipline, encouragement, the rod of correction, order. The top is affection, affirmation and fun.   Book Blitz: (9 books)   9:55 - Pursuit: 21-Day Prayer and Fasting Devotional - Practical takeaways for why fasting is a game-changer. 10:22 - Bible Recap by Tara-Leigh Cobble. - Daily Bible reading plan  - an app and a book. 11:08 - Man Maker Project: Boys are Born. Men are Made. (Chris Bruno)  - Unpacking the fatherlessness epidemic - Malachi verse - hearts of kids returning to fathers. "God's final warning is serious and dire. In essence the welfare of society rests on intentional fathers. Father well, God says, and the world will be blessed. Father poorly, and the world crumbles. It's really that big." 12:03 - Win the Day by Mark Batterson - daily rhythms for winning the day. Sponsored book for the F4F tour - free for every person who registers for the ride.  12:40 - Essentialism by Greg McKeown - What is the priority and how do we narrow our focus? 13:20 - Play the Man: Becoming the Man God Created You to Be by Mark Batterson - A template for dads and sons for how to "play the man" and "be the man." Quote from the book, "My father had, to a marvelous degree, the gift of opening doors for his children, of leading them into areas of splendid newness. This surely is the most valuable legacy we can pass on to the next generation. Not money, not houses, or heirlooms, but a capacity for wonder and gratitude, a sense of aliveness and joy." - Quoting Arthur Gordan 14:39 - Business Made Simple by Donald Miller - includes 60 free videos with his book. 14:52 - Autobiography of George Mueller - A man of faith who built orphanages in the UK filled with stories of miracle provision. 15:25 - Walking with God  by John Eldredge   Conversation Links:   Register for FATHERS FOR THE FATHERLESS Make a Donation to dadAWESOME Join the dadAWESOME Prayer Team

Shadowy figures lurking down an ally way, uncomfortable encounters with a random stranger but possibly the most terrifying is the inconspicuous neighbor who would do anything to help a friend. The darkness in humanity knows no boundaries. Welcome fellow travelers to the Gayest Sanctorum this is the Order of the Midnight Roller Podcast. We are your guides, Jamison, and Scully. And join us as we tiptoe through the thought twisting tunnels of the minds of Sadistic Serial Killers Kendall Francois (Poughkeepsie, NY) October 1996-August 1998 8 confirmed murders. An ex-Army vet and school Aid, janitor, and hall monitor for Arlington Middle school in Poughkeepsie, NY. He abducted 8 women and brought them back to where they had intercourse and then he would kill them, bathe them, and put his victims in garbage bags in his attic. After some time and many abductions, the smell came from the shabby home only a mile from the affluent Vassar College area. He was only caught when a victim escaped and ran into the investigating detectives as Kendall drove up. They questioned the girl about what had happened who stated it was Francois who assaulted her. The two detectives then went to the house where he Francois lived and asked him if he would come to headquarters and after several hours Francois confessed to many years of abductions and murder. After being convicted and sentenced he died of complications from HIV. H.H. Holmes/ Herman Webster Mudgett/Dr. Henry Howard Holmes (Chicago, Ill) 27 confirmed murders upwards of 200 assumed murder He killed his victims in a self-proclaimed “murder castle”. He began building the hotel in 1887. The building was supposed to be a hotel during the “World's Columbian Exposition”. There were soundproof rooms, hallways that lead nowhere, Chutes and ladders that lead to basements where he had acid baths and quick lime and crematorium to dispose of the bodies. Police only found this after having to go inspect the building when it was found the hotel was not in code. They found a surgical table and tools used to dissect bodies to sell organs on the black market. Holmes had supposedly murdered almost 300 people but was only convicted of killing his business partner after a botched insurance con. At the end of his life and after being convicted and sentenced to death he claimed that he was possessed by the devil. On the day of his hanging the “Murder Castle” was mysteriously burnt down. Later it was renovated into a Post Office until 1938. La Bestia: Luis Alfredo Garavito Cubillos was born on Jan 25, 1957, in Columbia. Has admitted to rape, torture, and murder of 138 teenagers and boys between ‘92 and ‘99. In his younger years, it is reported that his mother was a prostitute and his father was an alcoholic and was abusive. It is rumored that Garavito was subjected to abuse and molested by his mother's clients. He ran away at the age of 8 and unfortunately was picked up by a pedophile who raped and abused him. After this, he joined a gang for protection and began to steal. In 1992, an investigation began due to a large number of boys between 6 and 16 who had gone missing. In 1997 a mass grave with a pair of special glasses next to it. In ‘98 3 bodies were found with a note next to them with an address on it. The address was that of Garavito's girlfriend. When the police questioned her she had not seen him in months, however, she gave the police a bag Garavito left in her position. The bag contained photos and a journal containing how he killed his victims. This led the police to where he was staying. Though they believe he was looking for his next victim. He was convicted on 138 of 172 accounts of murder and was sentenced to 1,853 years and 9 days in prison, though there may have possibly been 300 or more victims due to the Columbian civil war.

In this episode John, Jay and Scott interview Norman Brosterman at Blockspot Learning in Southampton, NY (October 2015). We discussed the history of the Froebel Kindergarten and its impact on modern art, design and architecture. We've re-recorded the original questions as only Norman was mic'd at the time. For more information about Norman visit his website at www.brosterman.com and click here to purchase Norman's book Inventing Kindergarten. If you like this podcast, consider supporting us at: www.patreon.com/PathToLearning/ Visit us on the web at www.pathtolearning.us for more information on each of our podcasts.

Hello friends! October is going to be super crazy for us here at The V Spot, so Katt just wanted to drop in and give you an update and keep you informed on what's up! Don't forget if you're around Syracuse, NY October 19th we'll be at the CNY Veg Fest. Come say hi! But we'll see you all again real soon, with a refreshed, new, and better (if at all possible) V Spot. Dani and Katt are vegans. They take a not-too-serious look at being a vegan in the real world, making jokes, puns, segues, cat sounds, and the occasional good point along the way. If you're a vegan or veg-interested, they're here to help and entertain. Updating every Friday.