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The Dead Internet Theory posits online existence is fake. Articles we read, accounts we follow, content we consume—designed by AI to keep us clicking, scrolling, and buying. And... It might be right?In this episode you will:- Understand what the dead internet theory is.- Have the dead internet theory explained.- Finally understand the dead internet theory memes.
In a brand new episode of the Inside Track, we have major transfer news from across the Premier League - join host Will Balsam, Football Insider's senior correspondent Pete O'Rourke and former England international Paul Robinson to catch up with the very latest! The essential podcast for football fans. Get the latest exclusives directly on your phone thanks to our Whatsapp channel ➡️ https://whatsapp.com/channel/0 Subscribe to https://www.youtube.com/@footballinsiderchannel Follow us: Website: https://www.footballinsider247.com/ Facebook: / insiderfootball Twitter: / footyinsider247 Instagram: @football_insider247 YouTube Football Insider Football Insider is the official home of Football Insider's videos on YouTube, featuring our exclusive and breaking news, and all the best insight and analysis on the club you love. Make sure you subscribe and turn on notifications so you don't miss a single upload! Football Insider Football Insider - The inside track on the football stories that matter
In Episode 125, Corey your Shedadamus discusses: —Magic Round Puts the the Magic Back in Magical —Dogs vs. Raiders Could be a Perfect Fight —Mass Exodus at Bondi? —Round 10 Predictions —Gun of The Round You can reach Corey on Instagram (@outsidethesheds) or at outsidethesheds@gmail.com
America's Top Psychic Medium, James Van Praagh is interviewed about the deeper journey of the soul to the other side, opening up to the spirit world, 2025 predictions, U.S elections, E.T contact, and more. In this podcast, James Van Praagh & Emilio Ortiz explore the intricate relationship between grief, spirit communication, and the evolution of human consciousness.James Van Praagh is hailed throughout the world as a pioneer of the mediumship movement and considered one of the most widely recognized and accurate spiritual mediums working today.A “survival evidence medium,” he provides evidential proof of life after death through highly detailed messages from the spiritual realm. He is recognized annually on Watkins List of the 100 Most Spiritually Influential Living People – a prestigious list of spiritual teachers, activists, authors, and thinkers. He has worked with international heads of state, religious world leaders, and celebrities including Cher, Goldie Hawn, Shirley Maclaine, Ellen DeGeneres, Joan Rivers, Katie Couric, Loretta Lynn, Chelsea Handler, Jennifer Love Hewitt, Wesley Snipes, and so many more. The #1 New York Times best-selling author of over a dozen international best-sellers, including his debut, Talking to Heaven, Van Praagh's book titles include: Talking To Heaven, Reaching to Heaven, Healing Grief, Heaven and Earth, Looking Beyond, Meditations, Ghosts Among Us, Unfinished Business, Growing Up In Heaven, Adventures of the Soul, How to Heal a Grieving Heart, and The Power of Love.Several years back, he launched The James Van Praagh School of Mystical Arts which offers a variety of multimedia online learning experiences. He was the host of his own internationally syndicated television show, Beyond, and was a successful producer for CBS, creating a mini-series based on his life, Living with the Dead starring Ted Danson, and the very successful movie of the week, The Dead Will Tell starring Eva Longoria. He was also the executive producer of CBS's long-running series The Ghost Whisperer starring Jennifer Love Hewitt.___________________PODCAST CHAPTERS00:00 - James Van Praagh Intro02:01 - Discussing Human Rights and Voting in the U.S.03:46 - Soul Rights vs. Human Rights07:37 - Incarnating as Advanced Souls09:54 - Life Review and Consequences of Actions11:02 - Exploring Spiritual Realms and Spheres16:29 - Materializing Memories in the Afterlife18:39 - Soul's Journey After Death27:59 - Healing Grief and Spirit Communication33:18 - Mass Exodus of Souls and Purpose Behind World Events36:15 - Higher Purpose of Potential World Conflicts39:40 - Divine Will vs. Human Free Will44:38 - Aligning with Destiny Points48:29 - Power Without Ignorance53:23 - The Significance of Upcoming U.S. Elections57:30 - Preparing Humanity for Open Contact with Extraterrestrial Beings01:02:19 - Voice Frequency and Spirit Connection01:10:47 - The Joy of Teaching and the “Light Bulb” Moments01:17:20 - Advanced Lessons Humanity is Meant to Learn___________________Guest: James Van Praagh | World Renowned Psychic Medium✦ Website | https://vanpraagh.com/✦ JVP School of Mystical Arts | https://jvpschoolofmysticalarts.com/✦ Books & Cards | https://vanpraagh.com/books/✦ Live Events | https://vanpraagh.com/events/✦ Instagram | / jamesvanpraagh YouTube | @vanpraaghdotcom Host: Emilio Ortiz✦ Instagram | / iamemilioortiz ✦ Subscribe to YouTube Channel | @EmilioOrtiz ✦ Watch Emilio's latest series on 4biddenknowledge TV l https://bit.ly/AwakenThe6thSense© 2024 Emilio Ortiz. All rights reserved. Content from Just Tap In Podcast is protected under copyright law.Legal Disclaimer: The views, thoughts, and opinions expressed by guests on Just Tap In are solely those of the guest and do not necessarily reflect the views or opinions of Emilio Ortiz or the Just Tap In Podcast. All content is for informational purposes only and should not be considered professional advice.
In this episode, we delve into the top seven American cities experiencing significant population declines in 2025 and analyze the surprising trends in their real estate markets. Despite the exodus, cities like Baltimore, Detroit, Washington DC, San Francisco, Chicago, Los Angeles, and New York are seeing increases in home prices and rental incomes. We explore why this is happening, the opportunities it presents for savvy investors, and which specific neighborhoods are thriving amidst the broader urban challenges. Key insights include the importance of neighborhood-specific trends and the growing rental market, even as overall populations decline. The episode concludes with practical advice for investors and a free training offer for those looking to capitalize on these market dynamics. https://lunchbreakdeals.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
(05:25) GOING FOR IT: Vikings adding defensive players to take the burden off Brian Flores. Could Aaron Rodgers be the missing piece?(15:00) Commanders give Jayden Daniels some veteran help with trades for Deebo Samuel & Laremy Tunsil(20:25) Texans get better, and always have an eye on the future(27:20) QB CEILINGS: Was Sam Darnold really an upgrade over Geno Smith in Seattle?(32:15) Geno Smith makes the Raiders instantly better, until Brady finds his guy(36:50) Justin Fields signing still gives the Jets some flexibility(40:45) Why Daniel Jones is in a sticky situation with the Colts(47:45) FROM BAD TO ... LESS BAD? MEDIOCRE? GOOD?(48:00) Caleb Williams should benefit from the Bears beefing up the interior OL(51:15) Patriots splurge on D(54:40) Nowhere to go but up for the Giants secondary(58:30) The Panthers spent, but at what cost?(1:02:30) The Jaguars spent, but at what cost?(1:06:00) MASS EXODUS: 49ers have lost talent in droves. So how come the sports books don't reflect that?(1:14:35) Maybe now everyone will realize how great of a roster the Eagles have built(1:18:50) RETOOLING: Broncos, Bills, and Bucs have been sneaky good
49ers Reaction + Therapy: Kyle Juszczyk gone in mass exodus
Mass Exodus? When will the media learn? Twenty-one people quitting a government agency that was connected to DOGE is a lot different that a “Mass Exodus from DOGE.” When will government employees realize that adding more regulation does not actually make the world better? www.RealPowerFamily.com Info@ClearSkyTrainer.com 833-Be-Do-Have (833-233-6428)
There’s an opportunity on the table to leave with a group of colleagues to join another company. What are some risks to this mass exodus that you should be aware of? Have a work-related question to ask a career counsellor? Email us at cnapodcasts [at] mediacorp.com.sg See omnystudio.com/listener for privacy information.
Help support Blendr News and independent media by picking up a "Death by Taxes" hoodie:blendrnews.com-Get original articles, extended podcasts, and direct access to Blendr News on our Substack Channel: blendrnews.substack.com-In this episode of "The Blendr Report," Jonathan and Liam discuss:0:00 Intro0:40 RCMP and CSIS Fail to Justify Trudeau's Emergencies Act6:28 Canadians Deserve Accountability for EA10:18 Why Did Trudeau Invoke the EA?14:20 Did the Liberals Want Canadians to Fear Them?16:18 Trump Tariffs: On Again, Off Again22:14 Liberal Leadership Debate Centering Around Trump24:51 Mark Carney Moving Brookfield to America28:34 “Phase 1” of Epstein Files Was a Letdown 34:22 Has Epstein Evidence Been Destroyed?39:29 Mass Exodus of Liberal MPs43:00 Canada is Being Kamala Harris'd46:26 Ontario Election and Misleading Polls49:42 Mark Carney's Ties to WEF and China52:39 Trump vs China in Geopolitics1:00:31 Chinese Communist Party Infiltration of Canada1:03:03 Leaders Ruling Through Fear-Follow BLENDR News:Twitter - @BlendrNewsInstagram - @blendr.report TikTok - @blendrnews-Follow Jonathan:Instagram - @itsjonathanharveyTikTok - @itsjonathanharvey-Follow Liam:Instagram - @liam.out.loudTwitter - @liam_out_loudYouTube - @liam-out-loud
The walls are closing in—on the right people. Today on Badlands Daily, CannCon and Patrick Gunnels break down Trump's total war on the deep state, starting with the USAID takedown that has the regime in a full-blown panic. Turns out, 6,200 journalists and 707 media outlets worldwide were directly funded by the U.S. government—and now they're mysteriously unable to make payroll. Meanwhile, the CIA buyouts are stacking up, with over 40,000 bureaucrats already taking the deal, and Chuck Schumer just accidentally warned us that the IRS is next on the chopping block (yes, please). Plus, Mitch McConnell is literally falling apart, Marco Rubio snubs the G20's climate cult gathering, and Argentina just officially dumped the WHO, following Trump's lead. And in today's most misunderstood headline, Trump's Gaza Gambit has world leaders scrambling—what does it really mean when he talks about U.S. “ownership” of the Strip? Spoiler: It's not what the media is telling you. The deep state is on life support, and we're here for every second of the meltdown. Buckle up!
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On this full episode of LARRY with Larry O'Connor, we discuss CNN Anchor Jim Acosta's HUMILIATING exit from CNN, Scott Jennings going SCORCHED EARTH on an unsuspecting CNN panel, SANITY being carried out through Donald Trump's immigration policy, Selena Gomez's teary-eyed rant about Donald Trump, and MUCH, much more! SHOP OUR MERCH: https://store.townhallmedia.com/ Watch LARRY with Larry O'Connor LIVE — Monday-Thursday at 12PM Eastern on YouTube, Facebook, & Rumble! Find LARRY with Larry O'Connor wherever you get your podcasts! SPOTIFY: https://open.spotify.com/show/7i8F7K4fqIDmqZSIHJNhMh?si=814ce2f8478944c0&nd=1&dlsi=e799ca22e81b456f APPLE: https://podcasts.apple.com/us/podcast/larry/id1730596733 Become a Townhall VIP Member today and use promo code LARRY for 50% off: https://townhall.com/subscribe?tpcc=poddescription https://townhall.com/ https://rumble.com/c/c-5769468 https://www.facebook.com/townhallcom/ https://www.instagram.com/townhallmedia/ https://twitter.com/townhallcomBecome a Townhall VIP member with promo code "LARRY": https://townhall.com/subscribeSee omnystudio.com/listener for privacy information.
(AURN News) — At least 14 United Nations peacekeepers were killed and many others wounded when M23 rebels, backed by Rwanda, attacked U.N. positions in eastern Congo, the latest casualties in an escalating conflict that has forced hundreds of thousands to flee their homes. The attacks took place between January 23 and 24, when M23 rebels fired on positions held by the U.N. stabilization mission known as MONUSCO. U.N. Secretary-General António Guterres warned that attacks against U.N. personnel may constitute a war crime and called for an immediate investigation. He also demanded M23 cease hostilities and withdraw from occupied areas, while also calling on Rwandan defense forces to end their support of M23 and pull out of Congolese territory. The violence has triggered a humanitarian emergency in the region, with civilians facing dire conditions. "A major surge in violence in the eastern region of DRC has led to hundreds of thousands of people fleeing multiple active conflict zones," said Shelley Thakral, head of communications for the World Food Program in Congo. Thakral shared the updates during a special U.N. briefing on Tuesday. "WFP's priority is keeping staff and their dependents safe," Thakral said. "Only critical WFP staff remain in the area, and once the security situation improves, we can resume our emergency assistance and operations." The situation continues to deteriorate, according to Thakral. "There are growing protection concerns as hundreds of thousands of people have been displaced in and around Goma," she said. "Many are exposed to gender-based violence and with limited access to food, safe clean water and income, the risks facing the populations hour by hour, day by day will only increase in these volatile conditions." Learn more about your ad choices. Visit megaphone.fm/adchoices
This week, Jay and Ryan discuss if real estate agents will be leaving the industry in mass this year and why, the possibility of medical debt being barred from affecting credit scores, and the TikTok ban.
Jeremy Schnell, Jesse Morrison and Damon Allred discuss which players are returning for Arizona State football, if ASU men’s basketball can upset Kansas again and if ASU women’s basketball can take down Audi Crooks and Iowa State.has context menu
Seven of San Jose State's women's volleyball players have entered the transfer portal. Does this have anything to do with the teams transgender drama this year? Please Like, Comment and Follow 'Broeske & Musson' on all platforms: --- The ‘Broeske & Musson Podcast’ is available on the KMJNOW app, Apple Podcasts, Spotify or wherever else you listen to podcasts. --- ‘Broeske & Musson' Weekdays 9-11 AM Pacific on News/Talk 580 AM & 105.9 FM KMJ | Facebook | Podcast| X | - Everything KMJ KMJNOW App | Podcasts | Facebook | X | Instagram See omnystudio.com/listener for privacy information.
In this episode, I explore the evolution of marriage over the past century, discussing historical, cultural, and technological changes that have shaped modern relationships. Topics include the impact of the Industrial Revolution, agriculture changes, the sexual revolution, no-fault divorce, and technology. I also address the economic independence of women and the influence of technology on dating and relationships. While marriage has changed, it is not dead! I offer insights into how to navigate modern relationships successfully. Chapters 00:00 Intro 01:55 Industrial Revolution 03:01 Early 1900s: Cultural Shifts 04:20 WWII and the Baby Boom 05:25 Hormonal Birth Control 06:45 1970s: No-Fault Divorce 07:45 Women in the Workforce 08:30 Gen X and Latchkey Kids 11:25 Mass Exodus of Rural Areas 13:10 Tech Boom and Its Effects 15:27 2000s and Social Media 16:58 2007: Smartphones 18:40 Dating Apps 20:08 Summary and Consequences 24:00 Marriage isn't Dead! It Just Changed _____________________________ What Is Marriage Isn't Dead? Marriage Isn't Dead is an organization focusing on practical self-improvement advice for marriage, dating, career, work/life balance, entrepreneurship, parenting, and a healthy lifestyle. For more info visit: https://www.marriageisntdead.com “Marriage Isn't Dead” on all podcast platforms! Instagram: https://www.instagram.com/marriageisntdead/ Facebook: https://www.facebook.com/profile.php?id=61555370507017 Join the Private Facebook group: “Marriage Isn't Dead Private Group” TikTok: https://www.tiktok.com/@marriageisntdead YouTube: https://www.youtube.com/@MarriageIsntDead?sub_confirmation=1 Email: scott@marriageisntdead.com
Episode 4100: Biden Bleeds America DRY; Mass Exodus at DOJ!?
A leader for conducting rigorous randomized trials of humans along with animal models for understanding nutrition and metabolism, Dr. Kevin Hall is a Senior Investigator at the National Institutes of Health, and Section Chief of the Integrative Physiology Section, NIDDK. In this podcast, we reviewed his prolific body of research a recent publications. The timing of optimizing our diet and nutrition seems apropos, now that we're in in the midst of the holiday season!Below is a video snippet of our conversation on his ultra-processed food randomized trial.Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Note: I'll be doing a Ground Truths Live Chat on December 11th at 12 N EST, 9 AM PST, so please mark your calendar and join!Transcript with links to publications and audioEric Topol (00:05):Well, hello. This is Eric Topol with Ground Truths, and I'm really delighted to have with me today, Dr. Kevin Hall from the NIH. I think everybody knows that nutrition is so important and Kevin is a leader in doing rigorous randomized trials, which is not like what we usually see with large epidemiologic studies of nutrition that rely on food diaries and the memory of participants. So Kevin, it's really terrific to have you here.Kevin Hall (00:34):Thanks so much for the invitation.Ultra-Processed FoodsEric Topol (00:36):Yeah. Well, you've been prolific and certainly one of the leaders in nutrition science who I look to. And what I thought we could do is go through some of your seminal papers. There are many, but I picked a few and I thought we'd first go back to the one that you published in Cell Metabolism. This is ultra-processed diets cause excessive caloric intake and weight gain. (Main results in graph below.) So maybe you can take us through the principle findings from that trial.Kevin Hall (01:10):Yeah, sure. So that was a really interesting study because it's the first randomized control trial that's investigated the role of ultra-processed foods in potentially causing obesity. So we've got, as you mentioned, lots and lots of epidemiological data that have made these associations between people who consume diets that are very high in ultra-processed foods as having greater risk for obesity. But those trials are not demonstrating causation. I mean, they suggest a strong link. And in fact, the idea of ultra-processed foods is kind of a new idea. It's really sort of appeared on the nutrition science stage probably most prominently in the past 10 years or so. And I first learned about this idea of ultra-processed foods, which is really kind of antithetical to the way most nutrition scientists think about foods. We often think about foods as nutrient delivery vehicles, and we kind of view foods as being the fraction of carbohydrates versus fats in them or how much sodium or fiber is in the foods.Kevin Hall (02:17):And along came this group in Brazil who introduced this new way of classifying foods that completely ignores the nutrient composition and says what we should be doing is classifying foods based on the extent and purpose of processing of foods. And so, they categorize these four different categories. And in the fourth category of this so-called NOVA classification scheme (see graphic below) , they identified something called ultra-processed foods. There's a long formal definition and it's evolved a little bit over the years and continues to evolve. But the basic ideas that these are foods that are manufactured by industries that contain a lot of purified ingredients made from relatively cheap agricultural commodity products that basically undergo a variety of processes and include additives and ingredients that are not typically found in home kitchens, but are typically exclusively in manufactured products to create the wide variety of mostly packaged goods that we see in our supermarkets.Kevin Hall (03:22):And so, I was really skeptical that there was much more about the effects of these foods. Other than that they typically have high amounts of sugar and saturated fat and salt, and they're pretty low in fiber. And so, the purpose of this study was to say, okay, well if there's something more about the foods themselves that is causing people to overconsume calories and gain weight and eventually get obesity, then we should do a study that's trying to test for two diets that are matched for these various nutrients of concern. So they should be matched for the macronutrients, they should be matched for the sugar content, the fat, the sodium, the fiber, and people should just be allowed to eat whatever they want and they shouldn't be trying to change their weight in any way. And so, the way that we did this was, as you mentioned, we can't just ask people to report what they're eating.Kevin Hall (04:19):So what we did was we admitted these folks to the NIH Clinical Center and to our metabolic ward, and it's a very artificial environment, but it's an environment that we can control very carefully. And so, what we basically did is take control over their food environment and we gave them three meals a day and snacks, and basically for a two-week period, they had access to meals that were more than 80% of calories coming from ultra-processed foods. And then in random order, they either received that diet first and give them simple instructions, eat as much as little as you want. We're going to measure lots of stuff. You shouldn't be trying to change your weight or weight that gave them a diet that had no calories from ultra-processed foods. In fact, 80% from minimally processed foods. But again, both of these two sort of food environments were matched for these nutrients that we typically think of as playing a major role in how many calories people choose to eat.Kevin Hall (05:13):And so, the basic idea was, okay, well let's measure what these folks eat. We gave them more than double the calories that they would require to maintain their weight, and what they didn't know was that in the basement of the clinical center where the metabolic kitchen is, we had all of our really talented nutrition staff measuring the leftovers to see what it was that they didn't eat. So we knew exactly what we provided to them and all the foods had to be in our nutrition database and when we compute what they actually ate by difference, so we have a very precise estimate about not only what foods they chose to ate, but also how many calories they chose to eat, as well as the nutrient composition.And the main upshot of all that was that when these folks were exposed to this highly ultra-processed food environment, they spontaneously chose to eat about 500 calories per day more over the two-week period they were in that environment then when the same folks were in the environment that had no ultra-processed foods, but just minimally processed foods. They not surprisingly gained weight during the ultra-processed food environment and lost weight and lost body fat during the minimally processed food environment. And because those diets were overall matched for these different nutrients, it didn't seem to be that those were the things that were driving this big effect. So I think there's a couple of big take homes here. One is that the food environment really does have a profound effect on just the biology of how our food intake is controlled at least over relatively short periods of time, like the two-week periods that we were looking at. And secondly, that there's something about ultra-processed foods that seem to be driving this excess calorie intake that we now know has been linked with increased risk of obesity, and now we're starting to put some of the causal pieces together that really there might be something in this ultra-processed food environment that's driving the increased rates of obesity that we've seen over the past many decades.Eric Topol (07:18):Yeah, I mean I think the epidemiologic studies that make the link between ultra-processed foods and higher risk of cancer, cardiovascular disease, type 2 diabetes, neurodegenerative disease. They're pretty darn strong and they're backed up by this very rigorous study. Now you mentioned it short term, do you have any reason to think that adding 500 calories a day by eating these bad foods, which by the way in the American diet is about 60% or more of the average American diet, do you have any inkling that it would change after a few weeks?Kevin Hall (07:54):Well, I don't know about after a few weeks, but I think that one of the things that we do know about body weight regulation and how it changes in body weight impact both metabolism, how many calories were burning as well as our appetite. We would expect some degree of moderation of that effect eventually settling in at a new steady state, that's probably going to take months and years to achieve. And so the question is, I certainly don't believe that it would be a 500 calorie a day difference indefinitely. The question is when would that difference converge and how much weight would've been gained or lost when people eventually reached that new plateau? And so, that's I think a really interesting question. Some folks have suggested that maybe if you extrapolated the lines a little bit, you could predict when those two curves might eventually converge. That's an interesting thought experiment, but I think we do need some longer studies to investigate how persistent are these effects. Can that fully explain the rise in average body weight and obesity rates that have occurred over the past several decades? Those are open questions.Eric Topol (09:03):Yeah. Well, I mean, I had the chance to interview Chris van Tulleken who wrote the book, Ultra-Processed People and I think you might remember in the book he talked about how he went on an ultra-processed diet and gained some 20, 30 pounds in a short time in a month. And his brother, his identical twin brother gained 50, 60 pounds, and so it doesn't look good. Do you look at all the labels and avoid all this junk and ultra-processed food now or are you still thinking that maybe it's not as bad as it looks?Kevin Hall (09:38):Well, I mean I think that I certainly learned a lot from our studies, and we are continuing to follow this up to try to figure out what are the mechanisms by which this happen. But at the same time, I don't think we can throw out everything else we know about nutrition science. So just because we match these various nutrients in this particular study, I think one of the dangers here is that as you mentioned, there's 60% of the food environment in the US and Great Britain and other places consist of these foods, and so they're unavoidable to some extent, right? Unless you're one of these privileged folks who have your backyard garden and your personal chef who can make all of your foods, I'm certainly not one of those people, but for the vast majority of us, we're going to have to incorporate some degree of ultra-processed foods in our day-to-day diet.Kevin Hall (10:24):The way I sort of view it is, we really need to understand the mechanisms and before we understand the mechanisms, we have to make good choices based on what we already know about nutrition science, that we should avoid the foods that have a lot of sugar in them. We should avoid foods that have a lot of saturated fat and sodium. We should try to choose products that contain lots of whole grains and legumes and fruits and vegetables and things like that. And there's some of those, even in the ultra-processed food category. I pretty regularly consume a microwavable ready meal for lunch. It tends to be pretty high in whole grains and legumes and low in saturated fat and sugar and things like that. But to engineer a food that can heat up properly in a microwave in four minutes has some ultra-processing technology involved there. I would be pretty skeptical that that's going to cause me to have really poor health consequences as compared to if I had the means to eat homemade French fries every day in tallow. But that's the kind of comparison that we have to think about.Eric Topol (11:36):But I think what you're touching on and maybe inadvertently is in that NOVA class four, the bad ultra-processed foods, there's a long, long list of course, and some of those may be worse than others, and we haven't seen an individual ranking of these constituents. So as you're alluding to what's in that microwave lunch probably could be much less concerning than what's in these packaged snacks that are eaten widely. But I would certainly agree that we don't know everything about this, but your study is one of the most quoted studies ever in the ultra-processed food world. Now, let me move on to another trial that was really important. This was published in Nature Medicine and it's about a plant-based diet, which is of course a very interesting diet, low-fat versus an animal-based ketogenic diet. Also looking at energy intake. Can you take us through that trial?Plant-Based, Low Fat Diet vs Animal-Based, Low Carbohydrate Ketogenic DietKevin Hall (12:33):Sure. So it's actually interesting to consider that trial in the context of the trial we just talked about because both of these diets that we tested in this trial were relatively low in ultra-processed foods, and so both of them contained more than a kilogram of non-starchy vegetables as a base for designing these, again, two different food environments. Very similar overall study design where people again were exposed to either diets that were vegan plant-based diet that was really high in starches and was designed to kind of cause big insulin increases in the blood after eating the meals. And the other diet had very, very few carbohydrates of less than 10% in total, and we built on that kind of non-starchy vegetable base, a lot of animal-based products to kind of get a pretty high amount of fat and having very low carbohydrates. Both diets in this case, like I mentioned, were pretty low in ultra-processed foods, but what we were really interested in here was testing this idea that has come to prominence recently, that high carbohydrate diets that lead to really large glucose excursions after meals that cause very high insulin levels after meals are particularly obesogenic and should cause you to be hungrier than compared to a diet that doesn't lead to those large swings in glucose and insulin and the prototypical case being one that's very low in carbohydrate and might increase the level of ketones that are floating around in your blood, which are hypothesized to be an appetite suppressant. Same sort of design, these minimally processed diets that one was very high in carbs and causes large swings in insulin and the other that's very low in carbs and causes increases in ketones.Kevin Hall (14:22):We ask people, again, while you're in one food environment or the other, don't be trying to gain weight or lose weight, eat as much or as little as you'd like, and we're going to basically measure a lot of things. They again, don't know what the primary outcome of the study is. We're measuring their leftovers afterwards. And so, the surprise in this particular case was that the diet that caused the big swings in glucose and insulin did not lead to more calorie consumption. In fact, it led to about 700 calories per day less than when the same people were exposed to the ketogenic diet. Interestingly, both food environments caused people to lose weight, so it wasn't that we didn't see the effect of people over consuming calories on either diet, so they were reading fewer calories in general than they were when they came in, right. They're probably eating a pretty ultra-processed food diet when they came in. We put them on these two diets that varied very much in terms of the macronutrients that they were eating, but both were pretty minimally processed. They lost weight. They ended up losing more body fat on the very low-fat high carb diet than the ketogenic diet, but actually more weight on the ketogenic diet than the low-fat diet. So there's a little bit of a dissociation between body fat loss and weight loss in this study, which was kind of interesting.Eric Topol (15:49):Interesting. Yeah, I thought that was a fascinating trial because plant-based diet, they both have their kind of camps, you know.Kevin Hall (15:57):Right. No, exactly.Immune System Signatures for Vegan vs Ketogenic DietsEric Topol (15:58):There are people who aren't giving up on ketogenic diet. Of course, there's some risks and some benefits and there's a lot of interest of course with the plant-based diet. So it was really interesting and potentially the additive effects of plant-based with avoidance or lowering of ultra-processed food. Now, the more recent trial that you did also was very interesting, and of course I'm only selecting ones that I think are particularly, there are a lot of trials you've done, but this one is more recent in this year where you looked at vegan versus ketogenic diets for the immune signature, immune response, which is really important. It's underplayed as its effect, and so maybe you can take us through that one.[Link to a recent Nature feature on this topic, citing Dr. Hall's work]Kevin Hall (16:43):Yeah, so just to be clear, it's actually the same study, the one that we just talked about. This is a secondary sort of analysis from a collaboration we had with some folks at NIAID here at the NIH to try to evaluate immune systems signatures in these same folks who wonder what these two changes in their food environment. One is vegan, high carbohydrate low-fat diet and the other, the animal-based ketogenic diet. And again, it was pretty interesting to me that we were able to see really substantial changes in how the immune system was responding. First of all, both diets again seem to have improved immune function, both adaptive and innate immune function as compared to their baseline measurements when they came into the study. So when they're reading their habitual diet, whatever that is typically high in ultra-processed foods, they switched to both of these diets.Kevin Hall (17:39):We saw market changes in their immune system even compared to baseline. But when we then went and compared the two diets, they were actually divergent also, in other words, the vegan diet seemed to stimulate the innate immune system and the ketogenic diet seemed to stimulate the adaptive immune system. So these are the innate immune system can be thought of. Again, I'm not an immunologist. My understanding is that this is the first line defense against pathogens. It happens very quickly and then obviously the adaptive immune system then adapts to a specific pathogen over time. And so, this ability of our diet to change the immune system is intriguing and how much of that has to do with influencing the gut microbiota, which obviously the gut plays a huge role in steering our immune system in one direction versus another. I think those are some really intriguing mechanistic questions that are really good fodder for future research.Eric Topol (18:42):Yeah, I think it may have implications for treatment of autoimmune diseases. You may want to comment about that.Kevin Hall (18:51):Yeah, it's fascinating to think about that the idea that you could change your diet and manipulate your microbiota and manipulate your gut function in a way to influence your immune system to steer you away from a response that may actually be causing your body damage in your typical diet. It's a fascinating area of science and we're really interested to follow that up. I mean, it kind of supports these more anecdotal reports of people with lupus, for example, who've reported that when they try to clean up their diet for a period of time and eliminate certain foods and eliminate perhaps even ultra-processed food products, that they feel so much better that their symptoms alleviate at least for some period of time. Obviously, it doesn't take the place of the therapeutics that they need to take, but yeah, we're really interested in following this up to see what this interaction might be.Eric Topol (19:46):Yeah, it's fascinating. It also gets to the fact that certain people have interesting responses. For example, those with epilepsy can respond very well to a ketogenic diet. There's also been diet proposed for cancer. In fact, I think there's some even ongoing trials for cancer of specific diets. Any comments about that?Kevin Hall (20:10):Yeah, again, it's a really fascinating area. I mean, I think we kind of underappreciate and view diet in this lens of weight loss, which is not surprising because that's kind of where it's been popularized. But I think the role of nutrition and how you can manipulate your diet and still you can have a very healthy version of a ketogenic diet. You can have a very healthy version of a low-fat, high carb diet and how they can be used in individual cases to kind of manipulate factors that might be of concern. So for example, if you're concerned about blood glucose levels, clearly a ketogenic diet is moderating those glucose levels over time, reducing insulin levels, and that might have some positive downstream consequences and there's some potential downsides. Your apoB levels might go up. So, you have to kind of tune these things to the problems and the situations that individuals may face. And similarly, if you have issues with blood glucose control, maybe a high carbohydrate diet might not be for you, but if that's not an issue and you want to reduce apoB levels, it seems like that is a relatively effective way to do that, although it does tend to increase fasting triglyceride levels.Kevin Hall (21:27):So again, there's all of these things to consider, and then when you open the door beyond traditional metabolic health markers to things like inflammation and autoimmune disease as well as some of these other things like moderating how cancer therapeutics might work inside the body. I think it's a really fascinating and interesting area to pursue.Eric Topol (21:55):No question about it. And that also brings in the dimension of the gut microbiome, which obviously your diet has a big influence, and it has an influence on your brain, brain-gut axis, and the immune system. It's all very intricate, a lot of feedback loops and interactions that are not so easy to dissect, right?Kevin Hall (22:16):Absolutely. Yeah, especially in humans. That's why we rely on our basic science colleagues to kind of figure out these individual steps in these chains. And of course, we do need human experiments and carefully controlled experiments to see how much of that really translates to humans, so we need this close sort of translational partnership.On the Pathogenesis of Obesity, Calories In and Calories OutEric Topol (22:35):Yeah. Now, you've also written with colleagues, other experts in the field about understanding the mechanisms of pathogenesis of obesity and papers that we'll link to. We're going to link to everything for what we've been discussing about calories in, calories out, and that's been the longstanding adage about this. Can you enlighten us, what is really driving obesity and calories story?Kevin Hall (23:05):Well, I co-organized a meeting for the Royal Society, I guess about a year and a half ago, and we got together all these experts from around the world, and the basic message is that we have lots of competing theories about what is driving obesity. There's a few things that we all agree on. One is that there is a genetic component. That adiposity in a given environment is somewhere between 40% to 70% heritable, so our genes play a huge role. It seems like there's certain genes that can play a major role. Like if you have a mutation in leptin, for example, or the leptin receptor, then this can have a monogenic cause of obesity, but that's very, very rare. What seems to be the case is that it's a highly polygenic disease with individual gene variants contributing a very, very small amount to increased adiposity. But our genes have not changed that much as obesity prevalence has increased over the past 50 years. And so, something in the environment has been driving that, and that's where the real debates sort of starts, right?Kevin Hall (24:14):I happen to be in the camp that thinks that the food environment is probably one of the major drivers and our food have changed substantially, and we're trying to better understand, for example, how ultra-processed foods which have risen kind of in parallel with the increased prevalence of obesity. What is it about ultra-processed foods that tend to drive us to overconsume calories? Other folks focus maybe more on what signals from the body have been altered by the foods that we're eating. They might say that the adipose tissue because of excess insulin secretion for example, is basically driven into a storage mode and that sends downstream signals that are eventually sensed by the brain to change our appetite and things like that. There's a lot of debate about that, but again, I think that these are complementary hypotheses that are important to sort out for sure and important to design experiments to try to figure out what is more likely. But there is a lot of agreement on the idea that there's something in our environment has changed.Kevin Hall (25:17):I think there's even maybe a little bit less agreement of exactly what that is. I think that there's probably a little bit more emphasis on the food environment as opposed to there are other folks who think increased pollution might be driving some of this, especially endocrine disrupting chemicals that have increased in prevalence. I think that's a viable hypothesis. I think we have to try to rank order what we think are the most likely and largest contributors. They could all be contributing to some extent and maybe more so in some people rather than others, but our goal is to try to, maybe that's a little simple minded, but let's take the what I think is the most important thing and let's figure out the mechanisms of that most important thing and we'll, number one, determine if it is the most important thing. In my case, I think something about ultra-processed foods that are driving much of what we're seeing. If we could better understand that, then we could both advise consumers to avoid certain kinds of foods because of certain mechanisms and still be able to consume some degree of ultra-processed foods. They are convenient and tasty and relatively inexpensive and don't require a lot of skill and equipment to prepare. But then if we focus on the true bad guys in that category because we really understand the mechanisms, then I think that would be a major step forward. But that's just my hypothesis.Eric Topol (26:43):Well, I'm with you actually. Everything I've read, everything I've reviewed on ultra-processed food is highly incriminating, and I also get frustrated that nothing is getting done about it, at least in this country. But on the other hand, it doesn't have to be either or, right? It could be both these, the glycemic index story also playing a role. Now, when you think about this and you're trying to sort out calories in and calories out, and let's say it's one of your classic experiments where you have isocaloric proteins and fat and carbohydrate exactly nailed in the different diets you're examining. Is it really about calories or is it really about what is comprising the calorie?Kevin Hall (27:29):Yeah, so I think this is the amazing thing, even in our ultra-processed food study, if we asked the question across those people, did the people who ate more calories even in the ultra-processed diet, did they gain more weight? The answer is yes.Kevin Hall (27:44):There's a very strong linear correlation between calorie intake and weight change. I tend to think that I started my career in this space focusing more on the metabolism side of the equation, how the body's using the calories and how much does energy expenditure change when you vary the proportion of carbs versus fat, for example. The effect size is there, they might be there, but they're really tiny of the order of a hundred calories per day. What really struck me is that when we just kind of changed people's food environments, the magnitude of the effects are like we mentioned, 500 to 700 calories per day differences. So I think that the real trick is to figure out how is it that the brain is regulating our body weight in some way that we are beginning to understand from a molecular perspective? What I think is less well understood is, how is that food intake control system altered by the food environment that we find ourselves in?The Brain and GLP-1 DrugsKevin Hall (28:42):There are a few studies now in mice that are beginning to look at how pathways in the brain that have been believed to be related to reward and not necessarily homeostatic control of food intake. They talk to the regions of the brain that are related to homeostatic control of food intake, and it's a reciprocal sort of feedback loop there, and we're beginning to understand that. And I think if we get more details about what it is in our foods that are modulating that system, then we'll have a better understanding of what's really driving obesity and is it different in different people? Are there subcategories of obesity where certain aspects of the food environment are more important than others, and that might be completely flipped in another person. I don't know the answer to that question yet, but it seems like there are certain common factors that might be driving overall changes in obesity prevalence and how they impact this reward versus homeostatic control systems in the brain, I think are really fascinating questions.Eric Topol (29:43):And I think we're getting much more insight about this circuit of the reward in the brain with the food intake, things like optogenetics, many ways that we're getting at this. And so, it's fascinating. Now, that gets me to the miracle drug class GLP-1, which obviously has a big interaction with obesity, but of course much more than that. And you've written about this as well regarding this topic of sarcopenic obesity whereby you lose a lot of weight, but do you lose muscle mass or as you referred to earlier, you lose body fat and maybe not so much muscle mass. Can you comment about your views about the GLP-1 family of drugs and also about this concern of muscle mass loss?Kevin Hall (30:34):Yeah, so I think it's a really fascinating question, and we've been trying to develop mathematical models about how our body composition changes with weight gain and weight loss for decades now. And this has been a long topic, one of the things that many people may not realize is that people with obesity don't just have elevated adiposity, they also have elevated muscle mass and lean tissue mass overall. So when folks with obesity lose weight, and this was initially a pretty big concern with bariatric surgery, which has been the grandfather of ways that people have lost a lot of weight. The question has been is there a real concern about people losing too much weight and thereby becoming what you call sarcopenic? They have too little muscle mass and then they have difficulties moving around. And of course, there are probably some people like that, but I think what people need to realize is that folks with obesity tend to start with much higher amounts of lean tissue mass as well as adiposity, and they start off with about 50% of your fat-free mass, and the non-fat component of your body is skeletal muscle.Kevin Hall (31:45):So you're already starting off with quite a lot. And so, the question then is when you lose a lot of weight with the GLP-1 receptor agonist or with bariatric surgery, how much of that weight loss is coming from fat-free mass and skeletal muscle versus fat mass? And so, we've been trying to simulate that using what we've known about bariatric surgery and what we've known about just intentional weight loss or weight gain over the years. And one of the things that we found was that our sort of expectations for what's expected for the loss of fat-free mass with these different drugs as well as bariatric surgery, for the most part, they match our expectations. In other words, the expected amount of fat loss and fat free mass loss. The one outlier interestingly, was the semaglutide study, and in that case, they lost more fat-free mass than would be expected.Kevin Hall (32:44):Now, again, that's just raising a little bit of a flag that for whatever reason, from a body composition perspective, it's about a hundred people underwent these repeated DEXA scans in that study sponsored by Novo Nordisk. So it's not a huge number of people, but it's enough to really get a good estimate about the proportion of weight loss. Whether or not that has functional consequences, I think is the open question. There's not a lot of reports of people losing weight with semaglutide saying, you know what? I'm really having trouble actually physically moving around. I feel like I've lost a lot of strength. In fact, it seems to be the opposite, right, that the quality of the muscle there seems to be improved. They seem to have more physical mobility because they've lost so much more weight, that weight had been inhibiting their physical movement in the past.Kevin Hall (33:38):So it's something to keep an eye on. It's an open question whether or not we need additional therapies in certain categories of patients, whether that be pharmacological, there are drugs that are interesting that tend to increase muscle mass. There's also other things that we know increase muscle mass, right? Resistance exercise training, increase this muscle mass. And so, if you're really concerned about this, I certainly, I'm not a physician, but I think it's something to consider that if you go on one of these drugs, you might want to think about increasing your resistance exercise training, maybe increasing the protein content of your diet, which then can support that muscle building. But I think it's a really interesting open question about what the consequences of this might be in certain patient populations, especially over longer periods of time.Dietary Protein, Resistance Exercise, DEXA ScansEric Topol (34:30):Yeah, you've just emphasized some really key points here. Firstly, that resistance exercise is good for you anyway. And get on one of these drugs, why don't you amp it up or get it going? The second is about the protein diet, which it'd be interesting to get your thoughts on that, but we generally have too low of a protein diet, but then there are some who are advocating very high protein diets like one gram per pound, not just one gram per kilogram. And there have been studies to suggest that that very high protein diet could be harmful, but amping up the protein diet, that would be a countering thing. But the other thing you mentioned is a DEXA scan, which can be obtained very inexpensively, and because there's a variability in this muscle mass loss if it's occurring, I wonder if that's a prudent thing or if you just empirically would just do the things that you mentioned. Do you have any thoughts about that?Kevin Hall (35:32):Yeah, that's really a clinical question that I don't deal with on a day-to-day basis. And yeah, I think there's probably better people suited to that. DEXA scans, they're relatively inexpensive, but they're not readily accessible to everyone. I certainly wouldn't want to scare people away from using drugs that are now known to be very effective for weight loss and pretty darn safe as far as we can tell, just because they don't have access to a DEXA scanner or something like that.Eric Topol (36:00):Sure. No, that makes a lot of sense. I mean, the only reason I thought it might be useful is if you're concerned about this and you want to track, for example, how much is that resistant training doing?Kevin Hall (36:13):But I think for people who have the means to do that, sure. I can't see any harm in it for sure.Continuous Glucose Sensors?Eric Topol (36:19):Yeah. That gets me to another metric that you've written about, which is continuous glucose tracking. As you know, this is getting used, I think much more routinely in type one insulin diabetics and people with type 2 that are taking insulin or difficult to manage. And now in recent months there have been consumer approved that is no prescription needed, just go to the drugstore and pick up your continuous glucose sensor. And you've written about that as well. Can you summarize your thoughts on it?Kevin Hall (36:57):Yeah, sure. I mean, yeah, first of all, these tools have been amazing for people with diabetes and who obviously are diagnosed as having a relative inability to regulate their glucose levels. And so, these are critical tools for people in that population. I think the question is are they useful for people who don't have diabetes and is having this one metric and where you target all this energy into this one thing that you can now measure, is that really a viable way to kind of modulate your lifestyle and your diet? And how reliable are these CGM measurements anyway? In other words, do they give the same response to the same meal on repeated occasions? Does one monitor give the same response as another monitor? And those are the kinds of experiments that we've done. Again, secondary analysis, these trials that we talked about before, we have people wearing continuous glucose monitors all the time and we know exactly what they ate.Kevin Hall (37:59):And so, in a previous publication several years ago, we basically had two different monitors. One basically is on the arm, which is the manufacturer's recommendation, the other is on the abdomen, which is the manufacturer's recommendation. They're wearing them simultaneously. And we decided just to compare what were the responses to the same meals in simultaneous measurements. And they were correlated with each other thankfully, but they weren't as well predictive as you might expect. In other words, one device might give a very high glucose reading to consuming one meal and the other might barely budge, whereas the reverse might happen for a different meal. And so, we asked the question, if we were to rank the glucose spikes by one meal, so we have all these meals, let's rank them according to the glucose spikes of one device. Let's do the simultaneous measurements with the other device.Kevin Hall (38:53):Do we get a different set of rankings? And again, they're related to each other, but they're not overlapping. They're somewhat discordant. And so, then the question becomes, okay, well if I was basically using this one metric to kind of make my food decisions by one device, I actually start making different decisions compared to if I happen to have been wearing a different device. So what does this really mean? And I think this sort of foundational research on how much of a difference you would need to make a meaningful assessment about, yeah, this is actionable from a lifestyle perspective, even if that is the one metric that you're interested in. That sort of foundational research I don't think has really been done yet. More recently, we asked the question, okay, let's ignore the two different devices. Let's stick to the one where we put it on our arm, and let's ask the question.Kevin Hall (39:43):We've got repeated meals and we've got them in this very highly regimented and controlled environment, so we know exactly what people ate previously. We know the timing of the meals, we know when they did their exercise, we know how much they were moving around, how well they slept the night before. All of these factors we could kind of control. And the question that we asked in that study was, do people respond similarly to the same meal on repeated occasions? Is that better than when you actually give them very different meals? But they match overall for macronutrient content, for example. And the answer to that was surprisingly no. We had as much variability in the glucose response to the same person consuming the same meal on two occasions as a whole bunch of different meals. Which suggests again, that there's enough variability that it makes it difficult to then recommend on for just two repeats of a meal that this is going to be a meal that's going to cause your blood glucose to be moderate or blood glucose to be very high. You're going to have to potentially do this on many, many different occasions to kind of figure out what's the reliable response of these measurements. And again, that foundational research is typically not done. And I think if we're really going to use this metric as something that is going to change our lifestyles and make us choose some meals other than others, then I think we need that foundational research. And all we know now is that two repeats of the same meal is not going to do it.Eric Topol (41:21):Well, were you using the current biosensors of 2024 or were you using ones from years ago on that?Kevin Hall (41:27):No, we were using ones from several years ago when these studies were completed. But interestingly, the variability in the venous measurements to meal tests is also very, very different. So it's probably not the devices per se that are highly variable. It's that we don't really know on average how to predict these glucose responses unless there's huge differences in the glycemic load. So glycemic load is a very old concept that when you have very big differences in glycemic load, yeah, you can on average predict that one kind of meal is going to give rise to a much larger glucose excursion than another. But typically these kind of comparisons are now being made within a particular person. And we're comparing meals that might have quite similar glycemic loads with the claim that there's something specific about that person that causes them to have a much bigger glucose spike than another person. And that we can assess that with a couple different meals.Eric Topol (42:31):But also, we know that the spikes or the glucose regulation, it's very much affected by so many things like stress, like sleep, like exercise. And so, it wouldn't be at all surprising that if you had the exact same food, but all these other factors were modulated that it might not have the same response. But the other thing, just to get your comment on. Multiple groups, particularly starting in Israel, the Weizmann Institute, Eran Segal and his colleagues, and many subsequent have shown that if you give the exact same amount of that food, the exact same time to a person, they eat the exact same amount. Their glucose response is highly heterogeneous and variable between people. Do you think that that's true? That in fact that our metabolism varies considerably and that the glucose in some will spike with certain food and some won't.Kevin Hall (43:29):Well, of course that's been known for a long time that there's varying degrees of glucose tolerance. Just oral glucose tolerance tests that we've been doing for decades and decades we know is actually diagnostic, that we use variability in that response as diagnostic of type 2 diabetes.Eric Topol (43:49):I'm talking about within healthy people.Kevin Hall (43:53):But again, it's not too surprising that varying people. I mean, first of all, we have a huge increase in pre-diabetes, right? So there's various degrees of glucose tolerance that are being observed. But yeah, that is important physiology. I think the question then is within a given person, what kind of advice do we give to somebody about their lifestyle that is going to modulate those glucose responses? And if that's the only thing that you look at, then it seems like what ends up happening, even in the trials that use continuous glucose monitors, well big surprise, they end up recommending low carbohydrate diets, right? So that's the precision sort of nutrition advice because if that's the main metric that's being used, then of course we've all known for a very long time that lower carbohydrate diets lead to a moderated glucose response compared to higher carbohydrate diets. I think the real question is when you kind of ask the issue of if you normalize for glycemic load of these different diets, and there are some people that respond very differently to the same glycemic load meal compared to another person, is that consistent number one within that person?Kevin Hall (45:05):And our data suggests that you're going to have to repeat that same test multiple times to kind of get a consistent response and be able to make a sensible recommendation about that person should eat that meal in the future or not eat that meal in the future. And then second, what are you missing when that becomes your only metric, right? If you're very narrowly focused on that, then you're going to drive everybody to consume a very low carbohydrate diet. And as we know, that might be great for a huge number of people, but there are those that actually have some deleterious effects of that kind of diet. And if you're not measuring those other things or not considering those other things and put so much emphasis on the glucose side of the equation, I worry that there could be people that are being negatively impacted. Not to mention what if that one occasion, they ate their favorite food and they happen to get this huge glucose spike and they never eat it again, their life is worse. It might've been a complete aberration.Eric Topol (46:05):I think your practical impact point, it's excellent. And I think one of the, I don't know if you agree, Kevin, but one of the missing links here is we see these glucose spikes in healthy people, not just pre-diabetic, but people with no evidence of glucose dysregulation. And we don't know, they could be up to 180, 200, they could be prolonged. We don't know if the health significance of that, and I guess someday we'll learn about it. Right?Kevin Hall (46:36):Well, I mean that's the one nice thing is that now that we have these devices to measure these things, we can start to make these correlations. We can start to do real science to say, what a lot of people now presume is the case that these spikes can't be good for you. They must lead to increased risk of diabetes. It's certainly a plausible hypothesis, but that's what it is. We actually need good data to actually analyze that. And at least that's now on the table.Eric Topol (47:04):I think you're absolutely right on that. Well, Kevin, this has been a fun discussion. You've been just a great leader in nutrition science. I hope you'll keep up your momentum because it's pretty profound and I think we touched on a lot of the uncertainties. Is there anything that I didn't ask you that you wish I did?Kevin Hall (47:23):I mean, we could go on for hours, I'm sure, Eric, but this has been a fascinating conversation. I really appreciate your interest. Thank you.Eric Topol (47:30):Alright, well keep up the great stuff. We'll be following all your work in the years ahead, and thanks for joining us on Ground Truths today.**************************************Footnote, Stay Tuned: Julia Belluz and Kevin Hall have a book coming out next September titled “WHY WE EAT? Thank you for reading, listening and subscribing to Ground Truths.If you found this fun and informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.Note on Mass Exodus from X/twitter:Many of you have abandoned the X platform for reasons that I fully understand. While I intend to continue to post there because of its reach to the biomedical community, I will post anything material here in the Notes section of Ground Truths on a daily basis and cover important topics in the newsletter/analyses. You can also find my posts at Bluesky: @erictopol.bsky.social, which is emerging as an outstanding platform for sharing life science. Get full access to Ground Truths at erictopol.substack.com/subscribe
In this episode we discuss all the news that has popped off in the F1 world since the Brazilian GP. Multiple high ranking officials have been fired, quit, or have announced their departure. We've got another rookie confirmed to be coming to the grid for 2025 and George Russel has weilded his quill against the FiA!
President-elect Donald Trump's defense secretary nominee Pete Hegseth could provoke a purge of career military experts from the Pentagon—which appears to be exactly what he wants, explained The New Abnormal co-hosts Andy Levy and Danielle Moodie. Plus! Stephanie Mencimer, senior reporter at Mother Jones, delves deeper into the controversies and allegations surrounding Trump's attorney general nominee, former congressman Matt Gaetz. Hosted on Acast. See acast.com/privacy for more information.
How CONCERNED should Husker fans be about a lot of people leaving at the end of the season?
Is the world's trust in the dollar fading as gold becomes the new safe haven? Get the most affordable gold—own spendable 24K GoldNotes today and secure your wealth! http://buygoldnotes.com Gold has surged to new records, signaling a major shift as central banks globally diversify away from the US dollar. From geopolitical tensions to shifts in international trade dynamics, gold's rising prominence reflects a significant trend. The two key drivers: the need for a more stable reserve currency and a departure from the dollar-centric payment system. But why are global institutions betting on gold? And what does this mean for the dollar's future? In this video, we explore the forces fueling gold's ascent and what it might mean for global markets and personal investments. Discover rare, limited-supply silver coins in our Silver Team store's Ancient/Historic Coins section—claim your piece of history before they're gone! https://bit.ly/HistoricCoins Start investing in silver with automatic monthly shipments starting at 1 oz, and earn cash by helping others. Visit http://mysilverteam.com for more details. Get your 2024 Trump Silver Presidential Medal here: https://bit.ly/TrumpSilver Secure & Preserve your future against market & government unpredictability. Visit https://colonialmetalsgroup.com/rtd or call 888-521-2448 to speak with the professionals today. DISCLAIMER: The financial and political opinions expressed in this video are those of the guest and not necessarily of "Rethinking the Dollar." Views expressed in this video should not be relied on for making investment decisions or tax advice and do not constitute personalized investment advice. The information shared is for the sole purpose of education and entertainment only.
A Pima County Supervisor has called for the censure of that county's sheriff less than two weeks before Election Day. We'll hear how the race for Pima County Sheriff turned so contentious. Plus, an exhibit at a Valley museum tries to help us understand how — and why — we respond to art.
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The situation in Bangladesh has worsened, forcing the Prime Minister to flee the country. Let's recap what led us to this point and look at what the future might hold for Bangladesh and India. Full Newsletter: https://mailchi.mp/zeihan/protests-cause-a-mass-exodus-of-bangladesh
https://slasrpodcast.com/ SLASRPodcast@gmail.com This week we are joined by Jason Quinn. Jason is a former US Coast Guard Rescue Swimmer, Officially Rescue Swimmer #500 and currently works in civilian search and rescue and is the host of The Real ResQ Podcast - a podcast that is a compilation of personal stories from people who have put their lives on the line and made some incredible rescues. The stories told on The Real ReqQ Podcast remind us that “those in distress are praying for a miracle. They are going to get the people who join Jason on his podcast. Plus black bears are getting comfortable in the Pemi, A Mass Exodus, New Technology for search and rescue, nature is being very aggressive this week, a history segment on Jigger Johnson, the iconic and often drunk woodsman legend of the Northeast, a fatality on Half dome, recent hikes, blueberry picking advice, Notable hikes, and dad jokes, This weeks Higher Summit Forecast About Wild and Outdoors Wild and Outdoors Northeast Hiking List Tracker Instagram Northeast Hiking List Tracker Hiking/Backpacking Gear Winter Hiking Gear Topics Aurora the Hiking Chatbot Bushwhacking and off trail hiking Seek the Peak Fundraiser update Whale sinks a boat Snake Bite Venom shot Three Dog Rescues on the Presidentials - Proceed with caution if taking dogs to the Presidentials Recent Hikes - Warren Hart and Rayner Edmands, early trail building history Adams Slide Stomp and Knobbie hike the Great Gulf to complete the Terrifying 25 Dave Sh*ts in the Woods joins us for Notable Hike segment Guest of the week, Brad and CeLynn from Wild and Outdoor Recent Search and Rescue Show Notes Apple Podcast link for 5 star reviews SLASR Merchandise SLASR LinkTree LELT Race Series Bald Pate 10k Pleasant Mountain Race Another weird whale attack Snake Bite Antivenom advancement NH Paws Rescue hikers assisted off Mt. Jefferson Hiker suffering unknown illness, Tuckerman Ravine Injured Hiker, Albany Injured hiker Greeley Ponds Sabbaday Falls rescue Garfield Ridge Rescue Rescue on Dickey Mtn. Sponsors, Friends and Partners 24th Annual Seek the Peak Fieldstone Kombucha CS Instant Coffee 2024 Longest Day - 48 Peaks Mount Washington Higher Summits Forecast Hiking Buddies Vaucluse - Sweat less. Explore more. – Vaucluse Gear White Mountains Endurance Coaching
The Quicky news update for Tuesday, August 6th 2024 The Quicky is the easiest and most enjoyable way to get across the news every day. And it's delivered straight to your ears in a daily podcast so you can listen whenever you want, wherever you want...at the gym, on the train, in the playground or at night while you're making dinner. Click here to take the latest Mamamia survey and you'll go in the running to win one of five $100 gift vouchers Want to try our new exercise app? Click here to start a seven day free trial of MOVE by Mamamia. CREDITS Host/Producer: Audio Producer: Thom LionBecome a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.
https://slasrpodcast.com/ SLASRPodcast@gmail.com This week we are joined by Jason Quinn. Jason is a former US Coast Guard Rescue Swimmer, Officially Rescue Swimmer #500 and currently works in civilian search and rescue and is the host of The Real ResQ Podcast - a podcast that is a compilation of personal stories from people who have put their lives on the line and made some incredible rescues. The stories told on The Real ReqQ Podcast remind us that “those in distress are praying for a miracle. They are going to get the people who join Jason on his podcast. Plus black bears are getting comfortable in the Pemi, A Mass Exodus, New Technology for search and rescue, nature is being very aggressive this week, a history segment on Jigger Johnson, the iconic and often drunk woodsman legend of the Northeast, a fatality on Half dome, recent hikes, blueberry picking advice, Notable hikes, and dad jokes, This weeks Higher Summit Forecast Order Form for SLASR Podcast Patches About Jason The Real ResQ Podcast HeliCast Podcasts Alaska: Dangerous Territory (see 1:12:35 for Jason's Segment) Distinguished Flying Cross Topics Loon Echo Land Trust Race Series Black Bear at Lincoln Woods Massachusetts people love NH Geolocator for Helicopter SAR Nature Gone Wild Jigger Johnson Grizzly attack Pemi Float Uncontacted Tribes Half Dome Search for Massachusetts cold case victim in Barrington, NH Stomp picks up a hitchhiker Recent hikes on Pleasant Mountain Welcome Jason Quinn! Show Notes Apple Podcast link for 5 star reviews SLASR Merchandise SLASR LinkTree LELT Race Series Bald Pate 10k Pleasant Mountain Race Overly Friendly Black Bears in the Pemi A quarter of Mass residents plan to move New Device allows mobile geolocation of cell phones via Helicopter Major eruption at Yellowstone Hydrothermal, not volcanic, but can get much worse Whale capsizes boat off Portsmouth Bear waves to driver who let him pass One injured runner made the F&G reports Videos from Aravaipa Some History on Jigger Johnson More History on Johnson 72 year old fights off grizzly Uncontacted tribes still exist… A death on Half Dome cables Search in Barrington, NH related to an old case in Massachusetts Sponsors, Friends and Partners 24th Annual Seek the Peak Fieldstone Kombucha CS Instant Coffee 2024 Longest Day - 48 Peaks Mount Washington Higher Summits Forecast Hiking Buddies Vaucluse - Sweat less. Explore more. – Vaucluse Gear White Mountains Endurance Coaching
Stu Burguiere catches up on all the friends, family members, colleagues, and allies who have abandoned President Joe Biden's 2024 re-election campaign in earnest. Then, Stu reacts to North Carolina Lt. Gov. Mark Robinson's "controversial" comments from the weekend that the mainstream media has taken wildly out of context. And an update on Stu's efforts to free beleaguered actor/January 6 protestor Jay Johnston. TODAY'S SPONSORS: JASE EMERGENCY PREPAREDNESS ANTIBIOTICS Go to http://www.Jase.com today and enter code “STU” at checkout for a discount on your order MY PATRIOT SUPPLY Order as many kits as you need and SAVE $50 on each one. Free shipping included! Visit http://www.PrepareWithStu.com HILLSDALE COLLEGE Check out these self-paced courses today by visiting http://www.Hillsdale.edu/STU to enroll - it's free and easy to get started BALANCE OF NATURE Go to http://www.BalanceOfNature.com and use promo code ‘STU' to get 35% off your first order, plus a free Fiber and Spice supplement Learn more about your ad choices. Visit megaphone.fm/adchoices
Democrats must give Black Americans what we're asking for or lose election after election. It's just that simple. --- Send in a voice message: https://podcasters.spotify.com/pod/show/phillipscottpodcast/message Support this podcast: https://podcasters.spotify.com/pod/show/phillipscottpodcast/support
The Thought Leader Revolution Podcast | 10X Your Impact, Your Income & Your Influence
“I wanted to give people an idea of what the experience was actually like to someone who did it”Have you ever considered moving from a blue state to a red state? What it's like to leave a liberal stronghold and move to a more conservative region? Many of us have felt the pressure of political and cultural shifts in our hometowns and have considered relocating for a better lifestyle.Roger Simon is a highly acclaimed prize-winning author, Oscar-nominated screenwriter, and founder of a leading alternative conservative media conglomerate, who left Los Angeles and now writes for the Epoch Times, a publication known for its conservative viewpoints. He is also the author of the brand new book, American Refugees: The Untold Story of the Mass Exodus from Blue States to Red States. Roger shares his firsthand experience of moving from Los Angeles to Nashville, that are both personal and widely relevant.In Roger's new book, "American Refugees: The Untold Story of the Mass Exodus from Blue States to Red States", he shares the ups and downs of his family's relocation experience. From the political and ideological shifts to the personal and emotional challenges, Roger provides a candid look at what it's really like to make such a major life change.If you're intrigued by the political landscape in America and the significant movement of people from blue states to red states, be sure to check out Roger's book:American Refugees: The Untold Story Of The Mass Exodus From Blue States To red StatesRoger L. Simon on Epoch Timeshttps://www.theepochtimes.com/author/roger-l-simonVisit eCircleAcademy.com and book a success call with Nicky to take your practice to the next level.
Starting another explosive Hour— of The Steve Gruber Show— coming to you Live from Studio G in the heart of AMERICA— Fighting for you from the Foxhole of Freedom—willing to tell you the truth when nobody else will, I'm Steve Gruber, HERE ARE YOUR THREE BIG STORIES FOR THIS HOUR AMERICA! Number One— Multi-millionaire and Senator Elizabeth Warren is more than happy to jack up taxes on ordinary Americas—I mean what does she care? She has so much money it will never affect her— Number Two— Israel could be on the brink of all-out war with an enemy far more dangerous than Hamas—as Hezbollah continues to fire missiles into the Jewish state—provoking a wider war— Number Three— Ok time to dial in and dig deeper on the erosion of a key voting block from where they've been for decades—the mass exodus of black voters away from Joe Biden and the Democrats is becoming more evident all the time—BUT those on the left refuse to believe it—
The Dean's List with Host Dean Bowen – Parents in California are quietly withdrawing their children from public schools, reacting to radical legislation and controversial curricula. Enrollment has dropped 25% in a year. True education should focus on virtues like wisdom and honesty, but current trends in some schools promote divisive ideologies, prompting a mass exodus and a battle for the minds of America's youth.
On today's episode the gang discusses: 1) Kim Kardashian SLAMMED For Choosing Friends Over Therapy 2) 'The Acolyte' BOMBS, Shills Cry About Review Bombing 3) Sydney Sweeney, Glen Powell & More DITCH HOLLYWOOD 4) Trump Accused of Creeping on Taylor Swift For Over a Decade Learn more about your ad choices. Visit megaphone.fm/adchoices
Look. I love New Orleans as much or more than some. She has her beauties and she has her nightmares. I don't really know how to address this except to address it head on. My husband is a specialist psychiatrist and we cannot keep up with inflation of everything. I'm coming to you very vulnerable right now. I have built a brand around the city that I love so much. Property taxes. Homeowners insurance, (that is really hard to attain.) Car insurance that is laughable to most of the country. A private school system that is lovely but suffocating. How is New Orleans going to handle this? Luckily, we have our friends over at Berkshire and Hathaway And real estate with Steph. Luckily we have professionals that can help us steer and the direction we need to go. Whether it's on the South Shore or in the parish like Chalmette or on the North Shore. Stephanie knows everything and I'm excited to invite you to this conversation, because it is deep..Find everything about our amazing sponsor and representative Stephanie at www.realestatewithsteph.comThen later, we welcome our amazing partners over at Ochsner children's to bring our second segment of EMERGENCY!! With Dr. Mutter. I'm so excited about this because we have submissions from our amazing audience. The listeners submit their questions and if chosen by Dr. Mutter, they receive a gift card from Rouses markets!We are asking about summer holiday vacation! And the winner goes to Victoria Zemke! There are so many things that parents should be aware of during summer holiday and this segment will show you that. Congratulations to Victoria and we cannot wait to introduce the next segment of. EMERGENCY!! with Dr Mutter. Thank you to our family of amazing sponsors! Ochsner Hospital for ChildrenWww.ochsner.orgRouses MarkersWww.rousesmarkets.comSandpiper VacationsWww..sandpipervacations.comZak George's Dog Revolution! The Law Firm of Forrest Cressy & James Www.forrestcressyjames.comComfort Cases Www.comfortcases.orgNew Orleans Ice Cream CompanyWww.neworleansicecream.comReal Estate with Steph & Berkshire Hathaway www.realestatewithsteph.comAudubon Institute www.auduboninstitute.orgThe Gift of Adoption FundGiftofAdoption.org
BUY CAST BREW COFFEE TO FIGHT BACK - https://castbrew.com/ Become a Member For Uncensored Videos - https://timcast.com/join-us/ Hang Out With Tim Pool & Crew LIVE At - http://Youtube.com/TimcastIRL TRUMP WON Libertarian Convention, LEFTIST Wins Nomination Sparking MASS EXODUS To TRUMP & GOP 2024 Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome to the Shawn Bolz Show where we look at current events, the entertainment world, and what is happening around the globe from a Christian discerning perspective that hopefully inspires you to keep looking for what God is doing in the midst of what is going wrong. We have a big show for you today! People are fleeing blue states in mass, and it's official. How will this mass migration impact the upcoming elections? Are you financially prepared for any election outcome? Our financial expert shares crucial steps you can take to secure your finances. Plus, with a mental health crisis affecting over 50 million Americans, as reported by USA Today, and 1 in 4 suffering from diagnosable mental disorders according to Hopkins Medicine, does Christianity offer hope and healing for our soul, mind, spirit, and body? We'll explore this pressing issue and highlight the silver linings. Stay tuned for all this and more, exclusively on the Shawn Bolz Show! Restore the Foundations: https://restoringthefoundations.org Come join me on my Social Media: Facebook: Shawnbolz Twitter: ShawnBolz Instagram: ShawnBolz TikTok: ShawnBolz YouTube: ShawnBolzofficial Find me on TV: TBN: https://www.tbn.org/people/shawn-bolz Watch my series on the names of God: Discovering God series: https://bit.ly/3erdrJ9 Watch my series on hearing God's voice: Translating God series: https://bit.ly/3xbcSd5 Watch my weekly series/Vodcast on CBN News Network: Exploring the Marketplace https://bit.ly/3B81e41 Join me for my podcasts on Charisma Podcast Network: News Commentary: Prophetic Perspectives: https://bit.ly/3L9b5ej Exploring the Marketplace: https://bit.ly/3QyHoo5 Exploring the Prophetic: https://bit.ly/3QyHoo5 Take a class or attend an event at our Spiritual Growth Academy: Our 4 week classes and monthly events are designed to do the heavy lifting in your spiritual growth journey. Learn how to hear from God, stay spiritually healthy, and impact the world around you: https://bit.ly/3B2luDR Take a read: Translating God - Hearing God's voice for yourself and the world around you https://bit.ly/3RU2X3F Encounter - A spiritual encounter that will shape your faith https://bit.ly/3tNAW4Y Through the Eyes of Love - http://bit.ly/2pitHTb Wired to Hear - Hearing God's voice for your place of career and influence https://bit.ly/3kLsMn9 Growing Up With God - Chapter book and kids curriculum https://bit.ly/3eDRF5a Keys to Heaven's Economy - Understanding the resources for your destiny: https://bit.ly/3TZAc7u Read my articles: At CBN News : https://bit.ly/3BtwSdp At Charisma News : https://bit.ly/3RxPJtz Email My Assistant: assistant@bolzministries.com Our resources: resources@bolzministries.com Our office: info@bolzministries.com
- Kevin Sweeney's Covid Year-tweet - Illinois' mass exodus - UConn turned down Koby Brea PRESENTED BY MyBookie! Get a 50% bonus up to $1,000 on your first deposit with promo code SLEEPERS here: https://bit.ly/SLEEPERS
A recent survey commissioned by the Greater Boston Chamber of Commerce finds that, while almost 90% of surveyed residents between the ages of 20 and 30 in Greater Boston say they're satisfied with their daily lives, one in four plan to leave the region in the next five years. Those surveyed cited the high cost of housing, concerns with public transportation and the availability of quality jobs among the reasons contributing to their possible exodus. In today's episode, CEO and President of the Greater Boston Chamber of Commerce Jim Rooney joins The Common to discuss these survey findings and what they can tell us about our region. Greater Boston's daily podcast where news and culture meet.
In this episode, Dr. Wali Khan, DNAP, CRNA, gets real about the so-called nursing shortage and leads an insightful conversation about the systemic reasons behind the mass exodus of nurses from bedside roles, where they're headed next, and how to reignite your passion for nursing while maximizing your happiness as a nurse. It's a powerful, controversial, empowering and raw discussion that will hit home for all nurses.>>Read more about mass exodus of bedside nursingJump Ahead to Listen:[02:30] Mass exodus of nursing.[04:38] America's Caregivers on the Brink of Extinction?[08:05] Work-life balance and options.[12:11] Nursing shortages in healthcare.[16:00] Unsafe staffing and patient safety.[20:48] Nurses as social media influencers.[24:06] Healthcare system and shortages.[29:37] Access to healthcare treatment.[31:37] Nursing shortage and exodus.[35:08] Complacency and apathy.Connect with Wali on social media:Instagram: @wali_khannFor more information, full transcript and videos visit Nurse.org/podcastJoin our newsletter at nurse.org/joinInstagram: @nurse_orgTikTok: @nurse.orgFacebook: @nurse.orgYouTube: Nurse.org
The Dallas Cowboys lost three starters on Friday with Tyron Smith signing with the New York Jets. How do the Cowboys replace Smith moving forward and why didn't they try to re-sign him? Plus, Michael Gallup is released and Leighton Vander Esch retires. All that and so much more in this episode of the show!Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelNew customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)
The Dean's List with Host Dean Bowen – Policymakers do not stop to consider the mass exodus from public schools because of the educational product the public schools are delivering. Instead, they blame the exodus on the other educational options with which parents are presented, and policymakers attempt to bring those options into their orbital jurisdiction...
Brandon Marcello of "247 Sports" joins the show to talk his latest piece on roster turnover hitting Alabama, reaction from college coaches on the turmoil the Crimson Tide face, who's best equipped to take advantage of Nick Saban's retirement and more. SECU has new video content every day so make sure you're subscribed: https://www.youtube.com/channel/UCsQmBNkPOToCPXQOxQmS9eg Subscribe to SEC Unfiltered, the best SEC podcast on the internet: https://podcasts.apple.com/us/podcast/sec-unfiltered/id1441899352 Website: https://www.secunfiltered.com/ Discord: https://discord.gg/secunfiltered X: https://twitter.com/SECUnfiltered Instagram: https://www.instagram.com/secunfiitered/ Facebook: https://www.facebook.com/SECUnfiItered Podcast: https://podcasts.apple.com/pl/podcast/sec-unfiltered/id1441899352 Let's get it! Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode, Roger L. Simon joins Mark Bauerlein to discuss his new book “American Refugees: The Untold Story of the Mass Exodus from Blue States to Red States.” Music by Jack Bauerlein.
In this episode, Roger L. Simon joins Mark Bauerlein to discuss his new book “American Refugees: The Untold Story of the Mass Exodus from Blue States to Red States.” Music by Jack Bauerlein.
The state of Massachusetts earned the number-two spot in terms of most moved-out-of states in 2023. Callers flood the lines to tell the tales of their own exodus from the Draconian Commonwealth.
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