Podcasts about therapeutic strategies

IntroductionImagine trying to swim while holding a beach ball underwater – you might pull it off for a bit, but sooner or later that ball is bobbing to the surface. Masking ADHD can feel just like that. Many of us with ADHD learn early that our brains and behaviors can stand out, so we develop a “socially acceptable” persona to blend in. We smile, sit still, and force focus – all to hide our natural restlessness or distraction. This isn't about being fake; it's a survival strategy learned over years. But as the ADDA (Adult ADHD Organization) puts it, keeping that mask on “will take a lot of energy – and the same goes for hiding your ADHD symptoms” In this episode, we'll explore what masking looks like, why we do it, how it varies across individuals, and most importantly, how to gradually unmask without burning out.What Is Masking and Why We Do It“Masking” (also called camouflaging or impression management) means hiding ADHD-related behaviors to appear neurotypical, usually to avoid stigma or negative judgments. Psychologists trace the idea back to Russell Barkley, who noted roughly one-third of people with ADHD develop masking habit. In practice, this can mean sitting unnaturally still to hide hyperactivity, speaking slowly to avoid interrupting, or painstakingly rehearsing what to say in social situations. We do it for safety. Maybe a teacher, boss, or parent once told us our energy was “too much,” or we saw peers get punished for fidgeting. Over time, we absorb: if we let our ADHD out, we risk judgment, rejection, or even losing out on opportunities. In fact, research shows it's not paranoia: about 78% of adults with ADHD admit to concealing their symptoms at work for fear of discrimination In school, the disparity can be shocking – one study found students with overt ADHD behaviors are disciplined 3.5 times more often than their peers for the same actions. Add gender and cultural pressures, and masking can feel like the only path: for example, women with ADHD often face “double discrimination” (for having ADHD and for not fitting feminine organizational norms) and are 40% more likely than men to hide their diagnosis entirely. In short, from childhood on, many of us learn that showing our “whole” ADHD selves is risky or unwelcome. So we adapt. We smile when our mind is racing, offer practical reasons for missed details (“Sorry I'm late, traffic was a nightmare!”), and push down our impulsivity. This constant self-monitoring – judging every word, movement, or post you make – drains your brain like a marathon trainer. It literally spikes stress: one study found that simply drafting and editing an email to seem “normal” boosts cortisol by 45% – your body treats each message like a big performance reviewe. Over time, the nervous system can't tell the difference between a social slip-up and physical dange, so we end up trapped in a cycle of hyper-alertness, exhaustion, and anxiety.What Masking Looks LikeBecause masking is so ingrained, it can look subtle – almost invisible – to others. Here are some common signs:Forcing calmness: You feel restless or impulsive inside, but you keep your voice and movements unusually slow. Your leg might be itching to bounce, but you tuck it under the chair. (Essentially, you're acting tranquil on the outside to hide your inside.).Over-checking & perfectionism: You triple-check your work or double-back on a short text. It's not just organization; it's anxiety about making even a tiny mistake. You polish emails or assignments obsessively so no one will doubt you. This can buy you time socially, but it bleeds your time and energy.Mimicking behavior: You silently copy others. If classmates fidget with a pencil or crack jokes, you nod and do something similar, even if it feels unnatural. You rehearse social scripts or small talk lines so you don't stand out.Hyper-focusing to overcompensate: You push intense focus on tasks that are being observed. In a meeting, you might go above and beyond on one project to cover for the times your attention drifts away.Suppressing stims: You swallow small yelps when you're excited, hold in hand-flapping urges, or quietly tap your foot under the table so nobody notices your need to move.Masking emotions: Instead of expressing frustration or excitement, you “perform” a neutral or cheerfully appropriate response. You might bottle up anxiety during social events and then have a breakdown in private.Over time, these “adaptations” literally become a second job. You're constantly monitoring yourself: “Am I moving too much? Did I blurt out something weird? Should I rephrase that?” It can feel like juggling while walking a tightrope. Nothing about the self feels authentic anymore – you're playing roles, not being you. But it's understandable: many ADHDers grew up being rewarded for “good behavior” and punished for impulsivity. The very need to mask is born out of those early lessons.The Spectrum of Masking ExperiencesMasking isn't one-size-fits-all; it varies depending on who you are, your ADHD type, and even where you live. For example, many women with ADHD describe “quiet masking”: an exhausting act of looking calm and organized while feeling chaos inside. Research suggests women often mask more intensely – making extra lists, rehearsing conversations, or overstating competence – which partly explains why ADHD in girls is underdiagnosed. One online clinician notes that 82% of women with ADHD report taking excessive notes or lists as a main coping strategy, whereas men more often throw themselves into high-powered work or sports to cover their restlessness. Men, on the other hand, often face a different mask: society may expect them to “just power through” or hide vulnerability. They might channel their energy into accomplishments or humor while resisting showing any confusion or need for help. Non-binary folks often juggle multiple sets of expectations, effectively running two exhausting personas simultaneouslyHormones also play a role: many women report that masking feels easier at certain times of the month and nearly impossible at others. Studies find that in the week before a period (when estrogen drops), it may take two to three times the energy to hold the mask than usual. In real numbers, one analysis suggests neurodivergent women spend about 4.2 hours each day on masking behaviors (mental checklists, micro-adjustments, etc.) compared to 2.7 hours for men – almost two extra hours of invisible labor.Cultural and social context also shifts masking. If you live in a community that stigmatizes any difference, you may have learned to mask more completely. Queer or BIPOC individuals, for instance, often mask not just ADHD but intersectional identities – layering on extra caution. As a parent, you may have taught your child that only quiet, compliant behavior is “good,” so they never learned a louder style of coping. As an educator, you might see a child who seems well-behaved and think “no ADHD here,” while inside that child is using up all their energy to meet those external expectations. The takeaway: everybody's mask looks a bit different. What matters is the cost: all masking demands surplus energy, and when you're always paying that cost, the debt comes due.The Exhaustion CostSpeaking of cost – exhaustion is the hallmark of masking. It's not ordinary tiredness; it's an all-the-way-to-your-toes, bone-deep fatigue. Over time, masking takes an enormous toll on mental and physical health. Psychologists warn that chronic masking leads to “chronic stress, emotional exhaustion, and mental health struggles” like anxiety or depression. You might find yourself mentally blanking after social events, or breaking down over small setbacks. Rejection Sensitive Dysphoria (RSD) can worsen this: even a tiny hint of criticism triggers a panic that sends you scrambling to mask harder, which drains more energy.Imagine the analogy of a running car engine: for you, masking means the engine is revving constantly, even when parked. That steady drain pushes cortisol and adrenaline through your system day after day. In fact, one study found cortisol (the stress hormone) climbs nearly 50% higher when an ADHD brain is in “masking mode,” treating every text or conversation like a high-stakes. No wonder so many ADHDers talk about being “tapped out” by nightfall.The breakdown can look like burnout or even depression. Burnout may start targeted (you feel okay at home but depleted at work), whereas depression spreads gloom into all areas. The difference can blur when masking for years: you might not even recognize yourself under the layers of effort. Some call it an identity crisis – when the role you've played for so long crowds out who you actually are. Teachers and therapists note that people rapidly “unmasking” often feel lost at first, confused about what they truly feel versus what they've performed for so long.Chronic masking even shows up in our bodies. It turns out that intense mental effort – like keeping a fake version of you running all day – activates the same inflammation pathways as physical traum. In other words, the stress of constant performance can undermine your immune system and heart health just like chronic physical stress. People who have masked intensely for years sometimes develop exhaustion-related illnesses in mid-life (autoimmunity, chronic pain, etc.) at higher rates. The data is sobering: extreme mental strain is linked with roughly a 23% higher risk of heart disease and 50% higher risk of Type 2 diabetes.None of this means your experience is exaggerated or “all in your head” – it's very real. Masking might start as a child's coping trick, but it can become a hidden crisis of burnout and self-alienation. When we say “exhaustion in between,” we mean the haze between two states: who you pretend to be (masked) and who you hope to be (unmasked). That haze is filled with stress, self-doubt, and second-guessing everything you say and do.The Path to UnmaskingSo how do you step out of that haze? Psychologists and coaches emphasize that unmasking is a gradual process. It's not an all-or-nothing revelation; it's more like slowly lowering the mask corner by corner. First, you need safe spaces – people or places where you feel accepted even if you slip up. That might be a close friend who knows you have ADHD, a sympathetic coworker, or an ADHD support group. In these environments you can practice just being a little more you.Awareness is the first step. Start by recognizing the ways you've been masking. Make a list (mental or written) of behaviors you do to hide your symptoms. Maybe note times you felt especially drained. As one psychologist suggests, once you see your own patterns, “you can begin making small changes to live more authentically – without the exhaustion.”. Small changes might be as simple as choosing one meeting to not take perfect notes, or allowing yourself one moment of stimming where it feels safe. Each little crack in the facade eases the pressure.You do not have to do it alone. Working with an ADHD coach or therapist can provide support for this journey. They can help you build confidence in your unmasked self and develop coping techniques for tough moments. Support groups (online or in-person) are also powerful – hearing others' stories of unmasking can make you feel understood, and you'll pick up practical tips. Remember: there's no shame in needing a plan or support to shed layers you've held onto for years.Importantly, you have a right to yourself. Unmasking may feel scary at first – you might worry about disappointing people or losing opportunities. Indeed, relationships built on the masked you may strain when the real you emerges. But authenticity also invites real connections. Let people see why you needed that mask, and give them a chance to adjust. Most find that gradual honesty (e.g., letting someone know “I'm actually not great at meetings” or “I need a second to think, I have ADHD”) can lead to more empathy and support in the long run.Tips & StrategiesPractical Daily ToolsUse timers and structure: Make time visible. Set a Pomodoro timer (25 minutes focus, 5 minutes break) for tasks. Many ADHDers swear by visual timers or apps that count down work segments. This keeps your brain anchored and reminds it that it's okay to pause. Timers can also break hyperfocus and prompt you to check in with yourself.Practice mindfulness (even briefly): Mindfulness isn't about chanting om; it's simply noticing what's happening now. Try a two-minute breathing exercise or a grounding check (e.g. count five things you see) when you feel off-balance. Training attention like a muscle can gradually make it easier to stay present, instead of slipping into panicked self-monitoring.Body doubling: Work or study next to someone else, even if they're doing their own thing. This can be a friend, coworker, or a virtual co-working session. The presence of another person gives your brain a subtle social cue to stay on task. It sounds funny, but many ADHDers find it helps them focus and not procrastinate as much.Externalize information: Use sticky notes, apps, whiteboards – anything that gets things out of your head and into the world. Write to-do lists, set multiple alarms, and put reminders in plain sight. Our brains with ADHD often work better with external structures. For example, if you always misplace your keys, have a dedicated hook or dish for them; if you forget errands, put notes on your phone's home screen. This isn't laziness – it's smart strategy.Transition rituals: Create small routines to “switch gears” at key times. For instance, light a candle or play a specific song when you start work, and then another cue (closing a planner, stretching) when you end. These rituals tell your brain “work is starting (or ending)” and can reduce the jarring overwhelm of sudden task changes.Therapeutic Strategies and SupportTalk to an ADHD-aware therapist or coach: A professional who gets ADHD can help you unpack why you feel the need to mask, and teach coping tools that don't involve hiding. For example, they may work on managing emotional overload (RSD), building self-esteem, or creating realistic plans for ADHD challenges. As one source notes, “seek out a therapist or coach who understands what you are going through”. They can guide you through practices like cognitive reframing or co-regulation exercises.Join support groups or communities: You aren't alone in this. Connecting with others who share ADHD (in support groups, forums, or social media) can be a game-change. Sharing stories helps you feel validated and less isolated. You'll learn “if they do it too, it's not just me,” which is huge for reducing shame. Some groups even offer body doubling sessions or accountability partners, blending practical help with empathy.Consider medication or coaching: If you haven't already, speak to a medical professional about ADHD medication or executive function coaching. While not for everyone, proper medication can reduce the intensity of symptoms, which in turn can lighten the masking load (for instance, less need to hyper-focus or suppress stims). An ADHD coach or organizer can help set up routines and accountability that make daily life smoother. Even simple tips like using noise-cancelling headphones in an overstimulating class or workspace can cut sensory overload and ease the urge to mask your discomfort.Practice self-regulation techniques: Techniques like co-regulation (doing relaxation exercises with a trusted person) can help you manage anxiety during unmasking. Breathing exercises, grounding, or gentle movement breaks (take a short walk, stretch) can also break cycles of panic when you feel exposed. The key is to have these strategies ready before you need them, so you don't default to the old mask under stress.Mindset Shifts and Self-CompassionReframe your self-talk: Change the narrative from “I'm being fake” to something kind like “I'm doing what I need to feel safe right now. This simple mental shift reduces self-blame. Remember: masking began for a reason. It was a way to protect yourself in situations that felt unsafe or unaccommodating. Treat masking as what it is – a survival strategy – not a character flaw.Set realistic expectations (“Good enough is enough”): One therapist advises: you don't have to be perfect. If you mentally prepare for an outing by saying “I will do okay, but I might feel tired and that's fine,” you're giving yourself permission to be human. Lower the stakes. If a conversation goes a bit off script, remind yourself it's not the end of the world. You're learning new habits, so expect some wobble at first.Take structured breaks: Masking is tiring; build in after-care. Plan downtime after social or high-mask situations. For instance, if you have a big meeting, schedule a 15-minute quiet break afterward to decompress (read, meditate, or just stare at the ceiling). These “mask rest” breaks are not indulgence but necessary refueling. Even during an event, sneak micro-breaks: a few deep breaths in the restroom or a moment outside can reset your system.Engage in self-care rituals: After masking sessions, do something comforting: perhaps rock on a chair, hug a pillow, doodle, or listen to your favorite music. Physical movement can help shake off tension. Journaling can also help: write down what parts of the interaction felt draining, what felt okay, and what small things helped you cope. Each insight is gold for next time.Offer yourself compassion: Recognize the courage it takes to gradually be yourself. Each time you unmask a little, you're practicing bravery. When you catch yourself slipping into shame or “shoulding” on yourself, gently pause and remind: You deserve care and acceptance, even while you're figuring this out. Affirmations like “I am learning to be me” or celebrating small wins (e.g. “I spoke up for my needs today”) reinforce a kinder inner voice.ConclusionMasking may have been part of our childhood toolkit for surviving a world that didn't seem built for us, but carrying that weight forever is optional. As research shows, chronic masking comes with costs – physical, emotional, relational – that we are not obligated to pay indefinitely. By understanding why we masked and how it wears us down, we gain the power to change course. Unmasking is a journey of self-discovery and patience. It means gradually replacing exhaustion with authenticity. It means finding and creating spaces where our real selves can breathe.Finally, remember: there is no single “right way” to do this. Some days you'll need the mask a little longer; other days you'll fling it off completely. Each step toward honesty is progress. Embrace the support around you, use the tools that work, and give yourself credit. Over time, you'll find that as the masks slowly lift, life feels lighter – and so do you.This Substack is reader-supported. To receive new posts and support my work, consider becoming a free or paid subscriber. Get full access to carmen_authenticallyadhd at carmenauthenticallyadhd.substack.com/subscribe

Cancer now affects 30% to 50% of Americans, a massive increase from just 5% in 1900, reflecting how modern diets and lifestyles have reshaped your body's internal terrain Excess linoleic acid (LA) from seed oils triggers toxic byproducts, chronic inflammation, and mitochondrial breakdown, all of which weaken your body's defenses and fuel tumor growth Lowering LA intake from 7% to around 2% to 3% of daily calories has been shown to cut oxidative stress markers by 20% in as little as 12 weeks, giving your body a chance to recover A four-phase terrain restoration strategy uses seed oil elimination, staged carbohydrate reintroduction, gradual fiber restoration, and metabolic supports like intermittent fasting and exercise to rebuild resilience Simple daily steps — avoiding seed oils, rebuilding gut health, supporting mitochondria through movement and sleep, and tracking progress — give you control over your risk and long-term health

Naveen Pemmaraju, MD - How I Treat BPDCN: A Case-Based Exploration of Best Practices in Selecting and Providing Therapeutic Strategies

Naveen Pemmaraju, MD - How I Treat BPDCN: A Case-Based Exploration of Best Practices in Selecting and Providing Therapeutic Strategies

CME credits: 0.25 Valid until: 14-12-2025 Claim your CME credit at https://reachmd.com/programs/cme/advanced-therapeutic-strategies-and-resistance-mechanisms-in-cll/36332/ Listen to Dr. Shankara Paneesha and discover the evolving treatment landscape for relapsed CLL. Get insights on BTK resistance, new treatment options including cellular therapy, and the importance of patient-specific factors in treatment decisions.=

Clinical Pearls from Dr. Dominic D'Agostino: Therapeutic Strategies and Clinical Success with the Ketogenic Diet  For this week's episode of the Clinician's Corner, we're doing something differently. We have gone into the archives and pulled out clinical pearls from some of our favorite episodes, and we're starting today with one of our most popular interviews with Dr. Dominic D'Agostino - where we unpack the ketogenic diet in all its nuances.   This interview first aired back in 2023, and the full interview can be viewed here.    Clinical pearls we extracted from the original interview: When the ketogenic diet is best used clinically; when it's contraindicated; and how to structure it for best results What the latest research is telling us about therapeutic application of this protocol - from metabolic health to neurological considerations and cancer  Exogenous ketones: when and how to use them  The intricacies of macronutrient ratios and when/how to cycle in and out of ketosis Measurement: the best forms for tracking ketosis and other key biomarkers to monitor   The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/    Connect with Dr. D'Agostino: Website: https://drdominicdagostino.com/ Instagram:  https://www.instagram.com/dominic.dagostino.kt/    LinkedIn:  https://www.linkedin.com/in/dominic-d-agostino-156014b/ Twitter:  https://twitter.com/DominicDAgosti2      Learn more about the ketogenic diet here: https://ketonutrition.org/    Timestamps:  00:00 History and Uses of Ketogenic Diet 06:25 Liver's Role in Ketone Production 07:22 Preventing Kidney Stones on Keto 13:15 Ketogenic Diet Supplement Tips 14:58 Minimal Supplements for Ketogenic Diet 18:07 Misleading Marketing of 1,3-Butanediol 24:08 Advanced Hormone and Metabolomics Testing 27:20 Monitor Meds During Diet Changes Speaker bio:   Dr. D'Agostino is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.   Keywords:  ketogenic diet, therapeutic ketosis, blood ketone levels, exogenous ketones, metabolic therapies, epilepsy, neuroprotection, anti-seizure strategy, type 2 diabetes, weight loss, cancer, muscle wasting, Parkinson's disease, Alzheimer's disease, migraines, polycystic ovary syndrome, psychiatric disorders, bipolar disorder, anxiety, autism, traumatic brain injury, non-alcoholic fatty liver disease, stroke, GLUT1 deficiency, carnitine supplementation, kidney stones, electrolyte balance, MCT oil, creatine monohydrate, caffeine and ketone production, comprehensive blood work Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

On this episode, we discuss multiple sclerosis and describe its clinical presentations, types, and pathophysiology. We compare and contrast the efficacy, safety profiles, and clinical use of disease-modifying agents, supportive therapies, and monitoring strategies in the treatment of multiple sclerosis.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. If you purchase an annual membership, you'll also get a free digital copy of High-Powered Medicine 3rd edition by Dr. Alex Poppen, PharmD. HPM is a book/website database of summaries for over 150 landmark clinical trials.You can visit our Patreon page at the website below:  www.patreon.com/corconsultrx We want to give a big thanks to Dr. Alex Poppen, PharmD and High-Powered Medicine for sponsoring the podcast..  You can get a copy of HPM at the links below:  Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to say thank you to our sponsor, Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx We also want to thank our sponsor Freed AI. Freed is an AI scribe that listens, prepares your SOAP notes, and writes patient instructions. Charting is done before your patient walks out of the room. You can try 10 notes for free and after that it only costs $99/month. Visit the website below for more information: https://www.getfreed.ai/  If you have any questions for Cole or me, reach out to us via e-mail: Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com

Send us a textIn this mailbox episode, we dive into a listener question from Amy (name changed for privacy), who is struggling with the trauma bond with her narcissistic and emotionally neglectful mother. Amy shares her experience of emotional neglect, manipulation, gaslighting, and rejection—all while navigating the complicated reality of trying to maintain boundaries.Drs. Gemma and Justine discuss: ✔ What a trauma bond with a parent looks like – Why it's so difficult to break free ✔ The cycle of hope & rejection – Why emotionally neglectful parents keep you in a state of longing ✔ How narcissistic parents offload their shame onto their children – Understanding the “shame exchange” ✔ Why boundaries feel impossible with a narcissistic mother – The emotional toll of walking on eggshells ✔ Grief and healing – The painful but necessary process of accepting that your mother will never be the mother you needed ✔ Moving forward – Why reparenting yourself is key, and how to start choosing healthier relationshipsThis is a deeply validating episode for anyone struggling with a difficult or narcissistic parent. If you've ever felt stuck in an unhealthy dynamic, confused by your mother's inconsistent behavior, or burdened with guilt for setting boundaries, this discussion is for you.

Send us a textIn this episode, Dr Gemma takes a deep dive into one of the most common and persistent life patterns—people-pleasing. If you've ever found yourself constantly prioritizing others' needs over your own, struggling to say no, or feeling exhausted from always trying to keep the peace, this episode is for you.She explores:✅ What people-pleasing really is and why it's not just one behavior but a collection of patterns ✅ The three main schemas that drive people-pleasing ✅ How early experiences and conditioning shape this pattern and why it can be hard to break ✅ Six powerful self-reflection questions to help you tune into yourself, your needs and your emotionsThese six foundational questions are designed to help you:

Podcast Episode Summary: The Truth About Jodi Hildebrandt's Addiction Treatment Methods In this episode, we're diving deep into the controversial practices of Jodi Hildebrandt, whose addiction treatment strategies have come under scrutiny following a lawsuit and allegations of abuse. As an addiction counselor, I'll break down her methods, compare them to science-backed recovery approaches, and explore what truly works in addiction treatment.

Send us a textEpisode Description:Are you dating someone new and wondering if they're truly a good match? Or do you have a pattern of attracting emotionally unavailable or narcissistic partners? In this episode, Gemma breaks down The 7 Deadly Sins of the Narcissistic Dater—key warning signs that indicate deeper personality issues and potential toxic relationship dynamics.These signs often reveal themselves early—sometimes even on the first date. Recognizing them before you get emotionally invested can save you from heartbreak and manipulation.These behaviors aren't just annoying quirks—they're significant predictors of toxic relationship patterns. I also share 2 real success stories from women who've identified these red flags early, broken their old patterns, and found secure, emotionally available partners.Resources Mentioned in This Episode:

Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]

Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]

Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]

Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]

Get your 2025 decluttering inspiration calendar: http://www.overcomecompulsivehoarding.co.uk/2025  Come to a Dehoarding Accountability Zoom Session: http://www.overcomecompulsivehoarding.co.uk/ticket Subscribe to the podcast: https://www.overcomecompulsivehoarding.co.uk/subscribe Podcast show notes, links and transcript: http://www.overcomecompulsivehoarding.co.uk/  In today's episode, I ask Dr Chia-Ying Chou about the complex interplay between grief and hoarding. We'll explore how emotions like grief can trigger hoarding behaviour, the role an inner critic plays, and learn all about compassion-focused therapy – including why it's so much easier to offer compassion than to receive it. The timing is perfect, coinciding with National Grief Awareness Week in the UK. Grief and Hoarding Discussion Chia-Ying Chou discusses the non-direct link between grief and hoarding based on clinical experience. Factors such as resistance to grieving and avoiding vulnerability exacerbate hoarding. Grief can trigger hoarding behaviour to maintain a sense of control and avoid confronting loss. Host shares personal experiences of how grief intensified their hoarding behaviour. Grief and Possessions People keep deceased loved ones' belongings as a way to preserve their existence. Chou mentions the ambiguous preservation of loved ones through items. Anxiety and resistance to facing grief make organising or discarding possessions difficult. Complex Emotions in Grief Host reflects on the unexpected emotions in grief, like anger or impatience. Therapeutic Strategies for Grief and Hoarding Chou compares addressing resistance to grief to preparing for a challenging hike. Emphasis on resourcing, preparing mentally, and gathering support. Suggestions for a "baby-step" approach to facing fears and emotions. Inner Critic and Grief Host discusses journey with their inner critic and finding new approaches to handle it. Chou highlights how internal criticism is often related to grief and missed opportunities. Compassion-Focused Therapy (CFT) Integration of Western psychotherapy and Buddhist philosophy for addressing psychological challenges. Difficulty in receiving or directing compassion towards oneself. Connections Between Hoarding, Trauma, and Grief Patterns of loss, either tangible or intangible, among those who hoard. Episode ties with National Grief Awareness Week in the UK. Cultivating Compassionate Companions Idea of cultivating an imaginary compassionate companion for emotional support. Emphasis on emotions being a part of persona, not the true self. Emotions and Grief Management Pacing yourself. Chou recommends creating space for emotions to surface naturally. Encouragement to welcome emotions as a creative process in internal space. Examine fears and take small steps to engage with feelings.

In this insightful episode, we explore the transformative role of play and playfulness in paediatric occupational therapy from multiple perspectives. From real-life case studies to theoretical discussions on the STEPPSI model and polyvagal theory, we uncover how play enhances child development and therapy. Learn about the challenges and triumphs therapists face in incorporating fun into clinical practice, and discover strategies for balancing playful engagement with therapeutic goals. Through stories, research, and practical tips, we highlight the profound impact of playful interactions and social dynamics in fostering growth and emotional regulation in children.00:00 Exploring Play in Child Development01:16 The Origins and Evolution of STEP SI05:24 Personal Journeys into Pediatric Occupational Therapy08:05 The Vulnerability and Joy of Play10:03 Balancing Playfulness and Professionalism20:55 Clinical Reasoning in Play-Based Therapy25:18 Playfulness vs. Play: Definitions and Applications28:45 Case Study: Attuned Play in Therapy33:19 Struggles with Play and Skill Development34:28 Letting Go of the Agenda35:30 A Breakthrough in Play38:22 The Importance of Play in Therapy39:28 Navigating Play and Regulation41:31 Personal Reflections on Play45:20 Autonomic Nervous System in Play47:15 Grandchildren and Play Dynamics53:06 Therapeutic Strategies in Play59:14 Concluding Thoughts on PlayConnect with us: Instagram: https://www.instagram.com/spiritedconversations_ot/Facebook: https://www.facebook.com/spiritedconversationsOTYouTube: https://www.youtube.com/@spiritedconversations_OTWebsite: https://www.spiritedconversationspodcast.com/ Loved this episode and want an easy cost-free way to support us? Subscribe to our youtube channel! Hosted on Acast. See acast.com/privacy for more information.

In this informative episode, Nurse Doza explores the complexities of Hashimoto's thyroiditis, an autoimmune disorder affecting the thyroid. He delves into the root causes beyond just thyroid dysfunction, discusses manageable lifestyle changes, highlights the liver's crucial role, and emphasizes the importance of targeted supplementation. This comprehensive overview provides practical insights for those living with Hashimoto's, offering hope and actionable steps towards better health. 5 KEY TAKEAWAYS Hashimoto's often stems from previous infections, traumatic events, or lifestyle factors, not just thyroid issues. A gluten-free diet can significantly reduce thyroid antibodies associated with Hashimoto's. Managing stress is crucial, as it can trigger Hashimoto's flare-ups. The liver plays a vital role in thyroid hormone conversion and function. Targeted supplementation, especially zinc, selenium, and liver support, can improve Hashimoto's management. FEATURED PRODUCT Double the power with our Liver Boost and Berberine plus combo. This powerful duo is designed to support optimal liver function and metabolic health—key factors in managing Hashimoto's thyroiditis as discussed in this episode. By enhancing liver health, you can potentially improve thyroid hormone conversion and reduce inflammation, addressing the root causes of Hashimoto's beyond just thyroid function. SHOP HERE   TIMESTAMPS 00:00 START 01:00 Introduction to Hashimoto's thyroiditis 02:00 Previous infections and their role in Hashimoto's 05:00 Traumatic events and thyroid health 08:00 Importance of proper thyroid testing 11:00 Gluten's impact on thyroid health 14:00 Managing Hashimoto's through lifestyle changes 17:00 The liver's role in thyroid function 20:00 Nutrient deficiencies affecting thyroid health 22:00 Benefits of dry sauna for Hashimoto's 24:00 Importance of supplements in managing Hashimoto's   RESOURCES "Viruses and thyroiditis: an update" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654877/ "Posttraumatic stress disorder and risk of selected autoimmune diseases among US military personnel" https://pubmed.ncbi.nlm.nih.gov/30488818/ "Nutritional Approach to Thyroid Health: An Overview of the Current Evidence" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101513/ "Hashimoto Thyroiditis: An Update on Pathogenic Mechanisms, Diagnostic Protocols, Therapeutic Strategies, and Potential Malignant Transformation" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478900/ "Thyroid Hormones and the Liver: A Regulatory Network" https://link.springer.com/article/10.1007/s40618-020-01208-6 "The interrelationship between thyroid gland and liver: a review" https://www.sciencedirect.com/science/article/abs/pii/S0300508921006064 "Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review" https://onlinelibrary.wiley.com/doi/10.1155/2018/1857413  

Webinar Highlights Podcast: Join Professor Christopher Ritchlin, and Professor Philip Mease as they discuss the recent webinar hosted on the IMID Forum ‘Evolving Therapeutic Strategies for Psoriatic Diseases: Not all IL-23s are Created Similar - Part 2'. Watch them discuss key highlights from the webinar including the burden of PsA and PsO, the similarities and differences in pathology in skin and joints across psoriatic arthritis, and a special focus on IL-23, and its clinical data and impact across different tissue domains.

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GJT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Candid Conversations on Modern Urothelial Cancer Management: Personalizing Patient Care Using the Latest Evidence and Innovative Therapeutic Strategies In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Bladder Cancer Advocacy Network. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through educational grants from Astellas and Pfizer, Inc., Bristol Myers Squibb, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC (which are both Johnson & Johnson companies), and Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GJT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Candid Conversations on Modern Urothelial Cancer Management: Personalizing Patient Care Using the Latest Evidence and Innovative Therapeutic Strategies In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Bladder Cancer Advocacy Network. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through educational grants from Astellas and Pfizer, Inc., Bristol Myers Squibb, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC (which are both Johnson & Johnson companies), and Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GJT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Candid Conversations on Modern Urothelial Cancer Management: Personalizing Patient Care Using the Latest Evidence and Innovative Therapeutic Strategies In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Bladder Cancer Advocacy Network. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through educational grants from Astellas and Pfizer, Inc., Bristol Myers Squibb, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC (which are both Johnson & Johnson companies), and Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GJT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Candid Conversations on Modern Urothelial Cancer Management: Personalizing Patient Care Using the Latest Evidence and Innovative Therapeutic Strategies In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Bladder Cancer Advocacy Network. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through educational grants from Astellas and Pfizer, Inc., Bristol Myers Squibb, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC (which are both Johnson & Johnson companies), and Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GJT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Candid Conversations on Modern Urothelial Cancer Management: Personalizing Patient Care Using the Latest Evidence and Innovative Therapeutic Strategies In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and Bladder Cancer Advocacy Network. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported through educational grants from Astellas and Pfizer, Inc., Bristol Myers Squibb, Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC (which are both Johnson & Johnson companies), and Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

Parkinson's disease is a neurodegenerative disorder characterized by uncontrollable movements, stiffness, and cognitive decline. Curious? Come learn more! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below. National Institute on Aging. Parkinson's Disease: Causes, Symptoms, and Treatments. National Institute on Aging. Hogg E, Frank S, Oft J, Benway B, Rashid MH, Lahiri S. Urinary Tract Infection in Parkinson's Disease. Journal of Parkinson's Disease. 2022;12(3):743-757. ‌Yu J. Stages of Parkinson's | Parkinson's Foundation. www.parkinson.org. Published 2022. ‌Zhang ZX, Dong ZH, Román GC. Early Descriptions of Parkinson Disease in Ancient China. Archives of Neurology. 2006;63(5):782. ‌2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. www.youtube.com. 2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia. www.youtube.com. ‌Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment. Postgraduate Medical Journal. 2007;83(980):384-388. Zhang JF, Wang XX, Feng Y, Fekete R, Jankovic J, Wu YC. Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Frontiers in Psychiatry. 2021;12. Hisahara S, Shimohama S. Dopamine Receptors and Parkinson's Disease. International Journal of Medicinal Chemistry. 2011;2011:1-16. Houston. Tmc.edu. Published October 20, 2020. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter04.html‌Ovallath S, Sulthana B. Levodopa: History and Therapeutic Applications. Annals of Indian Academy of Neurology. 2017;20(3):185-189. ‌Levodopa | Parkinson's Foundation. www.parkinson.org. https://www.parkinson.org/living-with-parkinsons/treatment/prescription-medications/levodopa‌Kelly MJ, Baig F, Hu MTM, Okai D. Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(7):703-711. ‌Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011;34(1):441-466. ‌Sayare S. The Woman Who Could Smell Parkinson's. The New York Times. https://www.nytimes.com/2024/06/14/magazine/parkinsons-smell-disease-detection.html. Published June 14, 2024. ‌Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in Neurobiology. 2000;62(1):63-88. ‌Lanciego JL, Luquin N, Obeso JA. Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine. 2012;2(12):a009621-a009621. Climate ConfidentWith a new episode every Wed morning, the Climate Confident podcast is weekly podcast...Listen on: Apple Podcasts SpotifySupport the Show.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/QSV865. CME credit will be available until May 23, 2025.On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Blue Earth Diagnostics, Lantheus Medical Imaging, and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/QSV865. CME credit will be available until May 23, 2025.On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Blue Earth Diagnostics, Lantheus Medical Imaging, and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/QSV865. CME credit will be available until May 23, 2025.On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Blue Earth Diagnostics, Lantheus Medical Imaging, and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/QSV865. CME credit will be available until May 23, 2025.On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Blue Earth Diagnostics, Lantheus Medical Imaging, and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/QSV865. CME credit will be available until May 23, 2025.On Target: Understanding the Impact of PSMA for Diagnostic and Therapeutic Strategies in Prostate Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by educational grants from Blue Earth Diagnostics, Lantheus Medical Imaging, and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

Please visit answersincme.com/CGH860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in pulmonology discusses evidence and guidance on using multimodal approaches for managing patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Upon completion of this activity, participants should be better able to: Identify the continued needs with the currently available therapies for inoperable CTEPH; Review the clinical evidence for multimodal approaches in inoperable CTEPH in the context of currently available therapies; and Outline clinical factors that may facilitate optimal therapeutic selection for patients with inoperable CTEPH.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/CJD865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until April 24, 2025.Treatment Advances and Individualized Therapeutic Strategies in Prostate Cancer: Expert Insights on Key Evidence, Practical Tips for Personalized Therapy, and Clinical Integration Approaches In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and ZERO Prostate Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Astellas and Pfizer, Inc., Exelixis, Inc., Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/CJD865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until April 24, 2025.Treatment Advances and Individualized Therapeutic Strategies in Prostate Cancer: Expert Insights on Key Evidence, Practical Tips for Personalized Therapy, and Clinical Integration Approaches In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and ZERO Prostate Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Astellas and Pfizer, Inc., Exelixis, Inc., Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/CJD865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until April 24, 2025.Treatment Advances and Individualized Therapeutic Strategies in Prostate Cancer: Expert Insights on Key Evidence, Practical Tips for Personalized Therapy, and Clinical Integration Approaches In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and ZERO Prostate Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Astellas and Pfizer, Inc., Exelixis, Inc., Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/CJD865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until April 24, 2025.Treatment Advances and Individualized Therapeutic Strategies in Prostate Cancer: Expert Insights on Key Evidence, Practical Tips for Personalized Therapy, and Clinical Integration Approaches In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and ZERO Prostate Cancer. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis educational activity is supported by medical education grants from Astellas and Pfizer, Inc., Exelixis, Inc., Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and Novartis Pharmaceuticals Corporation.Disclosure information is available at the beginning of the video presentation.

Webinar Highlights Podcast: Join Professor Iain McInnes and Associate Professor Laura Coates on the Immune-Mediated Inflammatory Disease Forum in their discussion on the recent webinar “Evolving Therapeutic Strategies for Psoriatic Diseases: Not all IL-23s are Created Similar”. Watch them discuss key highlights from the webinar including the burden of PsA and PsO, the pathophysiology of IL-23 inhibitors compared with TNF and IL-17 inhibitor therapies, and the relationship between IL-23 inhibitor MOA variation and real-world patient data.

Join us on a transformative journey in this episode of "Mr. and Mrs. Therapy," where we have the privilege of hosting Erica Holmes, a distinguished Licensed Marriage and Family Therapist (LMFT) with a passion for supporting working mothers. Erica brings her expertise to the forefront, addressing the dual challenges of managing high-stress careers while embracing the pivotal role of motherhood. In today's fast-paced world, mothers are often caught in the whirlwind of professional ambition and familial responsibilities. Erica, through her therapeutic lens, offers unique insights into creating a harmonious balance that nurtures both career aspirations and the well-being of the family. What You'll Discover in This Episode: The Psychological Impact of Career Stress on Mothers: Erica elucidates the complex emotions and stressors faced by mothers in demanding careers, exploring the psychological implications and offering coping mechanisms. Therapeutic Strategies for Balance: Learn about tailored therapeutic approaches that assist mothers in navigating the challenges of work-life balance, drawing from Erica's rich experience as an LMFT. Creating a Supportive Environment at Home and Work: Discussion on how to cultivate understanding and support within professional environments and at home to foster a balanced life. Real-life Success Stories: Be inspired by stories from mothers who have successfully navigated the path to balance, highlighting practical examples and actionable advice. Self-Care and Mental Wellness: A deep dive into the importance of self-care for mental health, with Erica providing guidance on how mothers can prioritize their well-being amidst the chaos. Empowerment for Working Mothers: Erica shares empowering messages and affirmations to uplift mothers feeling the weight of their dual roles, reinforcing the idea that they are capable of achieving both personal and professional fulfillment. Connect with Tim & Ruth:  15 Minute Free Consultation Start healing now! Set up a Coaching Session [Remember, our podcast is here to spark conversations and offer insights. Join our community on our Mr. and Mrs. Therapy Podcast Group, share your experiences at podcast@mrandmrstherapy.com, and if you're seeking more personalized advice, consider booking your free coaching consultation. Please note, this podcast is for informational purposes only and is not intended to provide diagnosis or treatment.]

Featuring perspectives from Dr Melissa Johnson, including the following topics: Role of biomarker testing in optimal selection of first-line therapy for patients with non-small cell lung cancer (NSCLC) (0:00) Efficacy and safety with datopotamab deruxtecan for previously treated NSCLC (15:45) Antitumor activity with and current status of CEACAM5-targeted therapy for relapsed NSCLC (30:24) Evolution of drug development and clinical research (37:56) Key findings with sacituzumab govitecan for NSCLC (41:59) Telisotuzumab vedotin for patients with NSCLC and MET expression (48:44) Recent findings with tumor treating fields for metastatic NSCLC after disease progression on platinum-based therapy (50:49) Other novel antibody-drug conjugates under investigation for NSCLC (55:26) Case: A woman in her mid 50s with recurrent extensive-stage small cell lung cancer who developed pneumonitis on ifinatamab deruxtecan (59:05) Case: A woman in her early 60s with complete response to dose-reduced patritumab deruxtecan (1:00:15) CME information and select publications  

Dr Melissa Johnson from Sarah Cannon Research Institute in Nashville, Tennessee, discusses available data with antibody-drug conjugates with established and investigational targets in patients with non-small cell lung cancer.

Dr Melissa Johnson from Sarah Cannon Research Institute in Nashville, Tennessee, discusses available data with antibody-drug conjugates with established and investigational targets in patients with non-small cell lung cancer, moderated by Dr Neil Love. Produced by Research To Practice. CME information and select publications here (https://www.researchtopractice.com/OncologyTodayCEACAM5NSCLC23).

We're re-running an important episode on Alzheimer's disease — a topic that touches many people. We still don't have a complete understanding of the disease and that makes it hard to design effective therapies. In 2022, Russ Altman sat down with mechanical engineer Ellen Kuhl who offered a glimpse into the way she's using computational modeling to help improve our understanding of Alzheimer's disease.Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/XChapters:(00:00:00) Introduction Russ introduces the episode on Alzheimer's disease, highlighting its global impact, challenges treating it, and Dr. Ellen Kuhl's research on it.(00:02:08) The Approach and Research MethodsEllen Kuhl discusses her lab's interdisciplinary approach, and method of using existing data to create dynamic models to study the brain's lifecycle and degeneration in Alzheimer's disease.(00:03:46) Key Features of Alzheimer's Disease and DetectionBiomarkers of Alzheimer's, their role in brain cell death and cognitive decline, and the possibilities for early detection methods of these protein issues.(00:07:20) How Computational Models FunctionHow the models integrate various data points and physics principles to comprehensively understand Alzheimer's progression.(00:08:43) Spread of the DiseaseExploring the mechanisms of how Alzheimer's spreads from cell to cell in the brain, and the progression through the lobes of the brain, regardless of the cause genetic or trauma induced.(00:12:33) Interdisciplinary Collaboration The challenges and benefits of working as a mechanical engineer in Alzheimer's research and the opportunities of a multidisciplinary approach.(00:14:33) Alzheimer's Drug Development Modeling a controversial Alzheimer's drug, its potential impact, and the importance of early diagnosis for effective treatment.(00:16:04) Transition to COVID Research and ModelingHow the Alzheimer's model was rapidly adapated to study the spread of COVID-19, drawing parallels between brain regions and city networks.(00:18:38) Covid Modeling Learnings and ApplicationsHow their COVID models highlighted the importance of asymptomatic transmission and helped governments with reopening strategies.(00:20:24) Responsible Model Application The rampant and at times irresponsible use of  models during the pandemic, and metrics for measuring credibility of models(00:23:59) COVID Data SharingThe positive legacy of COVID-19, focusing on the accelerated progress facilitated by open and transparent data sharing.(00:24:53) Model Interpretability and ClosingInsights into the importance of model interpretability and the value of reducing complexity to enhance understanding. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/X

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: November 23, 2017 This week on BrainWaves, we build on concepts introduced in episode 65 regarding the non-pharmacologic management of drug-resistant epilepsy. In the next two episodes, you'll hear from Dr. Danielle Becker (Penn) and Dr. Myriam Abdennadher (NIH) on the minimally invasive procedures that can drastically impact the lives of patients with refractory seizures. Produced by James E Siegler. Music by Steve Combs, Jason Shaw, and Josh Woodward. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCES Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51(6):1069-77. Erratum in: Epilepsia 2010;51(9):1922. PMID 19889013Nilsson L, Farahmand BY, Persson PG, Thiblin I, Tomson T. Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet 1999;353(9156):888-93. PMID 10093982Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol 2008;7(11):1021-31. PMID 18805738Willie JT, Laxpati NG, Drane DL, et al. Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy. Neurosurgery 2014;74(6):569-84; discussion 584-5. PMID 24618797  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

In this episode, we are again joined by Thomas Seyfried, a Professor in Boston College's Biology Department. Not only does Thomas have immense responsibilities educating students, but he also runs a research program that develops new drug therapies for managing cancer.  Thomas is focused on understanding how metabolic therapy impacts chronic diseases like epilepsy, neurodegenerative lipid storage diseases, and cancer. By looking into alternative cancer treatments, scientists like Thomas are revolutionizing the future of healthcare – using natural metabolic therapies such as caloric restriction, fasting, and ketogenic diets in place of toxic alternatives… Jump in now to uncover: The types of cancer that Thomas is trying to understand and target.  Strategies for cancer management without toxicity.  What fermentation pathways are, and how they can generate energy without oxygen.  The #1 problem that all cancer cells share.  What the origin of cancer is. To learn more about Professor Thomas Seyfried and his work, click here now! Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: http://apple.co/30PvU9C