Podcasts about urolithin a

Why Wearing Sunscreen All Day May Be Doing More Harm Than Good for Women Over 40 In this thought-provoking episode, Angela Foster sits down with renowned beauty expert and author Liz Earle MBE to challenge conventional wisdom about sunscreen and sun exposure. Liz discusses why current public health messaging around universal, all-day SPF use might be too extreme, potentially robbing us of vital Vitamin D and other essential benefits of natural daylight. KEY TAKEAWAYS Many people assume they still get Vitamin D while wearing sunscreen. However, Liz points out that this only happens because most people apply it too thinly or miss spots.  Applying high SPF when it is completely unnecessary, like on a dark winter morning during an underground commute, is a sign that public health messaging has become too broad.  Our skin isn't just a physical barrier; it actively receives light and communicates with the body's immune system.  Exposing your skin to gentle, early-morning sunlight (when the UV index is low) acclimatizes it.  Medical professionals and researchers are beginning to speak out against extreme sun avoidance.  BEST MOMENTS "When people say, 'Yes, you get Vitamin D from the sun when you're using sunscreen,' yeah, because you're not using your sunscreen properly. You're actually allowing some of that UVB to come through the skin." "The worst thing that we can do is stay indoors all year and then rush out for our two-week summer beach holiday and fry ourselves on the beach... That's because our skin has not got used to the sunlight." "The skin is actually an organ of light reception. This is what we're just beginning to understand, that the skin has light receptors on it for reasons—they're signaling, it's not just blocking and keeping our insides intact." "I don't know if you take collagen supplements, I do, but actually by going out in early morning light, I'm telling my body to make more collagen. So it's preparing the skin." "He says that he thinks that we will look back at this time and our lack of sun exposure as being as damaging to our health as smoking." VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Ben Hartman is back for his third visit to the PricePlow Podcast in Episode #221, and Morphogen Nutrition has never been in a stronger position. Ben walks through everything: the second rebrand’s full backstory, a never-before-told story about a failed acquisition that nearly sold the company, the financial reckoning that followed, and how selling the building and moving to a 3PL model finally cleared the slate. He calls this the best formula work Morphogen has ever done, at the healthiest margins in company history. The conversation covers AlphaGEN’s return to 10g L-Tyrosine, why PRIME is the anchor of the entire health line, details like how he navigates AstraGin® and BioPerine® across a multi-product stack, and the surprising origin of CALM. Then comes the main event: the Nick Walker equity partnership, explained in full, including some of the financial structure the internet has been speculating about. The episode closes with a frank look at the longevity wave ahead, the natural-vs.-enhanced debate, and a nostalgic look back at the golden age of stimulants. Subscribe to the PricePlow Podcast on your favorite platform and sign up for Morphogen Nutrition news alerts before diving in. https://blog.priceplow.com/podcast/ben-hartman-morphogen-nutrition-221 Video: Morphogen’s Second Rebrand, Nick Walker Equity, and the 10g Tyrosine Return https://www.youtube.com/watch?v=1avyjD3spOk Detailed Show Notes: Ben Hartman on Morphogen’s Rebrand, the Nick Walker Deal, and Where Supplements Are Heading (0:00) – Introductions (0:45) – The Second Rebrand: What Triggered It (3:00) – The Failed Acquisition: First Public Account (5:00) – David DeMesquita: The Missing Third Partner (8:45) – Business Lessons: Termites at the Foundation (12:30) – Best Formulas Ever, Healthiest Margins Ever (13:15) – Hero vs. Backup Ingredients: Supply Chain and Formula Thinking (18:30) – Diminishing Returns: “Racing to the Bottom” (20:30) – Breaking the Debt Cycle: PO Discipline and the Move to 3PL (27:45) – ALPHAGEN Reborn: The 10g L-Tyrosine Decision (30:15) – Eria Jarensis, Manufacturing Partners, and Label Honesty (35:15) – PRIME: Origin Story and the Anchor Health Product (40:30) – AstraGin® and BioPerine®: Choosing Absorption Enhancers Wisely (46:30) – CALM: From Bodybuilding Contest Prep to Gen Pop (51:15) – “I Don’t Listen to My Customers” (54:45) – Blood Work, Hormones, and Realistic Self-Assessment (1:01:30) – The Nick Walker Partnership: How It Actually Happened (1:04:30) – Equity, Not a Paycheck: “We Gave It to Him” (1:11:30) – Nick’s Feedback, Carb Fuel, and PROTEGEN on the Way (1:16:45) – From Bodybuilding Brand to Health and Wellness (1:21:30) – The Longevity Wave: NMN, Urolithin A, and Mitochondrial Health (1:27:00) – Natural vs. Enhanced: An Honest Reassessment (1:35:00) – The Supplements That Actually Moved the Needle (1:38:00) – Stimulant Nostalgia: DMAA, Ephedrine, and What’s Still Available (1:40:45) – Dedra Hartman (CFO) and Closing Thoughts Where to Follow and Learn … Read more on the PricePlow Blog

Most women in perimenopause are training hard, eating well, and still dealing with joint pain, stiffness, and injuries that never fully heal. Juliet Starrett, New York Times bestselling author and co-founder of The Ready State, joins me to reveal why the joint pain and stiffness so many women write off as ageing is actually a specific syndrome nobody warned you about. We get into what 30 minutes of floor sitting a day can do for your hips and low back, why most exercise routines are silently narrowing your range of motion, and the five weekly movement non-negotiables Juliet recommends for every woman over 40. WHAT YOU'LL LEARN • Why perimenopause triggers joint pain, frozen shoulder, and mobility loss • How 30 minutes of floor sitting a day rewires your hips and reduces pain• Best movement habits for women over 40 • How strength training may be stealing your flexibility over time • How to train through injury without making it worse • The HRV myth debunked and what to track instead VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body and how to fix it.

Whittling your diet down to five "safe" foods isn't healing your gut — it's masking a deeper imbalance that declining estrogen may be driving. Nutrition expert Cynthia Thurlow joins Angela Foster to unpack why so many women suddenly can't tolerate foods they once ate freely, and what's really happening behind the bloating, palpitations and brain fog. The conversation explores the link between estrogen loss and a leaky small intestine, the histamine-hormone "perfect storm" that can trigger hives and cramping, and why bloating during perimenopause is so often multifactorial. Cynthia also explains when bloating becomes a red flag worth investigating. You'll learn how to identify your personal food triggers without cutting entire food groups, why eating in a parasympathetic state matters, and which gut supports — from fibre and hydration to TUDCA — can help as progesterone and estrogen decline. If you've ever felt like your body suddenly turned against your favourite foods, this episode will help you understand why. KEY TAKEAWAYS Stop eliminating food groups as your default fix. Whittling your diet down to a handful of "safe" foods signals an underlying gut imbalance that needs support — not an ever-expanding exclusion list. Recognise food sensitivities as a likely leaky gut symptom. As estrogen declines it acts like failing "mortar" in the small intestinal lining, letting food particles leak into the bloodstream and provoke an immune response. Watch the histamine-estrogen "perfect storm." During high-estrogen days, loading up on high-histamine foods (leftovers, kombucha, fermented items) can trigger hives, congestion, cramping and diarrhoea — so keep histamine foods low or infrequent during those windows. Eat in a parasympathetic state. Sit at a table, remove distractions, and take four to five deep breaths before meals rather than eating standing, in the car, or on the move. Always get persistent bloating evaluated. Bloating from morning to night is different from bloating that appears after meals, and persistent symptoms should be checked because, in rare cases, they can signal something serious like ovarian cancer. QUOTES "The goal is to never get to a point where you're excluding entire classes of foods." "If we look at the small intestinal lining as like a brick and mortar system, the mortar is the estrogen." "I literally was talking to a podcast host and I broke out in hives head to toe because I was high estrogen, high histamine stress. And it was like the perfect storm." "It's not really that you need to cut out all these food groups. We just have a nuanced conversation. Don't go overboard with any one food." "I've just seen too many people blow off symptoms for a year or two that end up being bigger issues than they would have been had they been addressed up front." VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

In dieser Folge spreche ich mit Dr. Stephan Barth, promoviertem Mediziner und interdisziplinärem Lebenswissenschaftler, über die heimlichen Heldinnen unseres Stoffwechsels: die Mitochondrien. Diese winzigen Zellkraftwerke, nur 1,5 Mikrometer groß und milliardenfach in unserem Körper vorhanden, entscheiden darüber, wie viel Energie wir haben, wie wir altern und wie gesund wir bleiben. Stephan Barth hat fast zwei Jahrzehnte in der Karlsruher Ernährungs- und Präventionsforschung gearbeitet und nimmt mich mit auf eine Reise durch zwei Milliarden Jahre Evolution, hinein in die Welt der Energieproduktion unserer Zellen. Wir sprechen darüber, warum unsere Mitochondrien ausschließlich von der Mutter kommen, wieso sie als Dirigentin im Orchester des Alterns gelten und welche Energievampire sie tagtäglich schwächen. Außerdem geht es um die Rolle von Bewegung, Ernährung, Stress und Schlaf, um die Bedeutung von Coenzym Q10, NAD+, Urolithin A und anderen Nahrungsergänzungsmitteln und darum, wie wir unsere Mitochondrien-Fitness messen und gezielt stärken können. In dieser Folge sprechen wir u.a. über folgende Themen: • Warum nennt Stephan Barth die Mitochondrien die heimlichen Heldinnen unseres Stoffwechsels? • Wie entstand die zwei Milliarden Jahre alte Symbiose zwischen Bakterien und unseren Zellen? • Warum erbst du deine Mitochondrien ausschließlich von deiner Mutter? • Wie viel ATP produziert dein Körper tatsächlich an einem einzigen Tag? • Was sind freie Radikale, und wieso sind sie nicht nur schlecht? • Wie funktioniert die Mitophagie, also die Selbstreinigung deiner Zellkraftwerke? • Was bewirken Bewegung, Fasten, Kälte und sekundäre Pflanzenstoffe als positive Stressoren? • Was sind die größten Energievampire für unsere Mitochondrien im Alltag? • Warum gelten Mitochondrien als Dirigentin im Orchester des Alterns? • Wie können wir unsere Mitochondrien-Fitness überhaupt messen? • Was brauchen Mitochondrien an Mikronährstoffen und welche Ernährung tut ihnen gut? • Was hält Stephan Barth von Nahrungsergänzungsmitteln wie NAD+, NMN, Urolithin A oder Spermidin? Weitere Informationen zu Dr. Stephan Barth findest du hier:Website: www.drstephanbarth.com LinkedIn: linkedin.com/in/dr-stephan-barthBuch: Die heimlichen Heldinnen des Stoffwechsels von Lea Hümbs, Stephan Barth - styriabooks.at Du interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder YouTube. https://www.instagram.com/nina.ruge.official https://www.tiktok.com/@nina.ruge.official https://www.facebook.com/NinaRugeOffiziell https://www.youtube.com/channel/UCOe2d1hLARB60z2hg039l9g Disclaimer: Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin. STY-284

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comThis week on the podcast, Mikki speaks to Brad Currier, Science Lead at Timeline Nutrition and lead author of the recent American College of Sports Medicine position stand on resistance training.In this episode, the conversation begins with Urolithin A and Mitopure, exploring what it is, what it does in the body, and why it has become an area of interest for mitochondrial health and muscle function. Brad explains the proposed mechanisms, the current human evidence, and what outcomes have actually been shown to improve, from cellular-level changes through to potential real-world benefits.Mikki and Brad also discuss who may be the best fit for a supplement like this, including older adults, athletes, and those already doing the fundamentals well, while also addressing the limitations of the current research and how to think about bias when science and industry intersect.The conversation then shifts to resistance training, where Brad shares key takeaways from the ACSM position stand he led, including what matters most for strength, hypertrophy, and health, and what people can probably stop overthinking.It's a balanced, evidence-informed conversation about mitochondrial health, supplementation, strength training, and the practical foundations that still matter most.Brad Currier is the Science Lead at Timeline Nutrition, where his work focuses on translating emerging research on mitochondrial health into practical, evidence-based applications. In particular, he has been closely involved in the science and communication around Urolithin A, the active ingredient in Mitopure, and its potential role in supporting muscle function, cellular energy, and healthy ageing.With a background in exercise science and resistance training research, Brad brings a dual lens to his work—combining performance-focused insights with a broader interest in longevity and metabolic health. He has contributed to large-scale evidence syntheses in resistance training, helping clarify what actually matters for strength, hypertrophy, and overall health, and where the field may have overcomplicated things.At Timeline, his role sits at the intersection of research, education, and application, helping bridge the gap between mechanistic science, clinical relevance, and real-world use—particularly as interest grows in interventions that support muscle and mitochondrial function across the lifespan.Brad Currier https://www.instagram.com/bradcurrier.phd/• ACSM Position Stand on Resistance Training (2026) - https://journals.lww.com/acsm-msse/fulltext/2026/04000/american_college_of_sports_medicine_position.21.aspx• Timeline Nutrition - https://www.timeline.com• Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nzContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

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Navigating midlife body changes can feel like waking up in a completely different body, even when your routine hasn't changed. Around 15% of active women transition through menopause without experiencing significant weight gain, finding that standard calorie deficits and exercise still work. However, the vast majority notice that previously effective fitness and nutrition habits suddenly stop yielding results. This shift is highly associated with a changing hormonal environment—specifically decreasing estradiol and declining progesterone levels—rather than just the natural ageing process. While it seems logical that hormone replacement therapy (HRT) would be the perfect fix, the reality is much more complex. HRT yields highly variable results for body composition; it helps some lose fat, has no impact on others, and can even cause weight gain. WHAT YOU'LL LEARN Approximately 15% of active women navigate menopause without significant weight gain and can still successfully lose weight using standard calorie deficits. For many women, the fitness and nutrition strategies that worked five or ten years ago become noticeably less effective during midlife. Accelerated fat gain during menopause is heavily associated with decreasing estradiol and progesterone levels, alongside rising follicle-stimulating hormone (FSH). Distinguishing between weight gain caused by natural ageing and weight gain caused specifically by menopause remains a complex challenge for researchers. Hormone therapy does not offer a universal solution for weight management, with individual results varying wildly from fat loss to unexpected fat gain. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus weekly MMA, he shifted to one zone 2 session, one Norwegian 4x4 VO2 max workout, and one MMA session weekly. He defines VO2 max and details the 4x4 protocol (4 minutes hard/3 minutes easy for 4 rounds plus brief warmup/cooldown), using a COROS heart rate monitor to track significant zone 5 time. Starting at 8.0 mph, he increased treadmill speed by 0.1 mph weekly to 9.3 mph, discussing deload weeks, fatigue limits, body weight changes, footwear, sauna frequency, and mixed views on supplements like beta-alanine, beetroot, and ketones.   Norwegian 4x4 Protocol https://www.myworkout.com/en/4x4-intervals VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio Stats Canada VO2 Max Percentile Table https://www150.statcan.gc.ca/n1/pub/82-003-x/2019010/article/00002/tbl/tbl02-eng.htm Oura Ring https://ouraring.com/ COROS Heart Rate Monitor https://coros.com/heart-rate-monitor Freak Athlete Nordic Hyper / Hyper Pro https://freakathlete.co/products/hyper-pro HOKA Clifton 10 https://www.hoka.com/en/ph/clifton-10-run-smooth/ Nike Zoom Fly https://www.nike.com/ph/w/nike-zoom-fly-running-shoes-37v7jz7oc5azy7ok Post-Exercise Sauna Bathing Study https://pubmed.ncbi.nlm.nih.gov/16877041/ Urolithin A https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 Beetroot / Dietary Nitrate https://www.ausport.gov.au/ais/nutrition/supplements/group_a/performance-supplements2/beetroot-juicenitrate Ketone-IQ https://ketone.com/ Beta-Hydroxybutyrate / BHB Ketones https://www.ncbi.nlm.nih.gov/books/NBK493179/ L-Citrulline https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Creatine https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Beta-Alanine https://examine.com/supplements/beta-alanine/ MOTS-c https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/ Cardarine / GW501516 https://www.wada-ama.org/en/news/wada-issues-alert-gw501516 Brady Holmer https://www.bradyholmer.com/ Hart2Heart Episode with Brady Holmer https://open.spotify.com/episode/0DxQVb0Mkah57ZgHbWmWUy   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 VO2 Max Story Setup 01:27 Baseline Training Split 02:58 What VO2 Max Means 05:10 Why Add Structure 06:01 Norwegian 4x4 Explained 06:49 Starting Speeds Recovery 08:07 Zone 5 Targets 10:55 Tracking Heart Rate 12:23 Estimating VO2 Max 14:37 Zone 2 And MMA Role 17:20 Bodyweight And Running 19:46 Shoes Sauna Supplements 24:44 Progressive Overload Plan 29:34 Deloads Plateaus Mindset 31:29 Final Takeaways Encouragement   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

00:00 Einführung: Sarcopenie als Problem 01:24 Der Müll wird nicht mehr abgeholt 04:08 Wenn der Muskel vernarbt 06:26 Stammzellen: Ursache oder Folge? 08:01 Das Nervensystem – der vergessene Faktor 09:13 Hormone – komplizierter als gedacht 10:41 Was das alles bedeutet 12:22 Outro ________ Patreon mit exklusive Folgen: https://www.patreon.com/thecoachcoachcorner Mein Instagram: https://instagram.com/hybridathlet Individuelle Coachings: http://www.become-fit.de Meine Bücher: https://www.amazon.de/kindle-dbs/entity/author/B01MG4H6WB Die Untersuchung: https://pubmed.ncbi.nlm.nih.gov/41837678/ In der Podcast-Folge von KWMIB geht es um Sarkopenie, also den altersbedingten Verlust von Muskelmasse und Kraft. Dabei wird deutlich gemacht, dass es sich nicht um ein Randproblem handelt, sondern um einen Prozess, der nahezu jeden Menschen im Alter betrifft, wenn nicht aktiv gegengesteuert wird. Da bislang kein zugelassenes Medikament existiert, richtet sich der Blick auf die biologischen Ursachen und auf praktikable Gegenmaßnahmen. Im Mittelpunkt steht zunächst der gestörte Muskelstoffwechsel im Alter. Ein zentrales Problem ist das dauerhaft überaktive Signalprotein mTORC1. Obwohl es grundsätzlich am Muskelaufbau beteiligt ist, verhindert seine chronische Aktivierung wichtige Selbstreinigungsprozesse der Zelle, insbesondere die Autophagie. Die Folge ist, dass sich beschädigte Proteine und Zellbestandteile ansammeln. Gleichzeitig verändert sich die extrazelluläre Matrix des Muskels: Das Gewebe wird steifer, lagert mehr Kollagen ein und vernarbt zunehmend. Diese Fibrose verschlechtert nicht nur die Muskelkontraktion, sondern beeinträchtigt auch die Funktion von Stammzellen, die für Reparatur und Regeneration wichtig wären. Hinzu kommt, dass mit zunehmendem Alter motorische Nervenzellen verloren gehen. Dadurch werden Muskelfasern schlechter angesteuert, was zu Atrophie führt. Auch die Muskelstammzellen selbst verlieren an Funktionsfähigkeit, weil sie im Alter oft zu früh aktiviert werden und bei echtem Reparaturbedarf bereits erschöpft sind. Zusätzlich spielt ein gestörter Aminosäurestoffwechsel eine Rolle: Aminosäuren werden nicht mehr effizient verarbeitet, was das ohnehin überaktive mTORC1-System weiter antreibt. Bei den Hormonen wird zwischen Männern und Frauen unterschieden. Testosteron spielt für Männer eine wichtige Rolle, bei Frauen ist eher Östrogen relevant. Allerdings zeigen Hormonersatztherapien nicht automatisch eine Verbesserung der alltagsrelevanten Muskelfunktion. Als wirksamste Strategie gegen Sarkopenie nennt der Podcast weiterhin klassisches Krafttraining kombiniert mit einer ausreichenden Proteinzufuhr von etwa 1,2 bis 1,6 Gramm pro Kilogramm Körpergewicht. Ergänzend werden Kreatin, Urolithin A und experimentell auch Rapamycin diskutiert. Das Fazit: Sarkopenie ist komplex, lässt sich aber durch Training und Ernährung deutlich bremsen.

Dr. Corey Schuler, PhD(c), FNP, DC, CNS, and director of medical affairs at Allergy Research Group, details his paper “Energy Allocation Resilience and Endocrine Integration” in the International Journal of Molecular Sciences. He introduces the Energy Allocation System (EAS), which emphasizes how the body allocates energy—not just produces it—and links many symptoms to impaired bioenergetics and resilience. They discuss mitochondria as energy generators and cellular signaling hubs, the integrated stress response and endocrine coordination (HPA axis, thyroid, gonads), and mitohormesis/eustress (exercise, fasting, heat/cold, circadian “zeitgebers”). Schuler explains nuanced testing for fatigue (diurnal cortisol, CGM patterns, thyroid markers including T3/reverse T3) and a case of a perimenopausal woman where oral contraceptives and cortisol dysregulation affected glucose patterns. They cover mitochondrial support (removing obstacles like pollutants/antibiotics, triglycerides, carnitine, dietary fats, micronutrients) and pacing/sequencing lifestyle interventions.

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Anurag Singh MD, PhD. is a physician, researcher, immunologist, and one of the leading voices behind the science of Urolithin A – a gut microbiome metabolite. Urolithin A is crucial for mitochondrial health by stimulating mitophagy. Dr. Singh breaks down the science and explains his extensive research into how this postbiotic compound could play a major role in cellular energy and longevity. Whether you’re an athlete, a health optimizer, or just curious about the future of longevity science, this conversation with Dr. Anurag Singh is packed with cutting-edge, evidence-based insights you won’t want to miss. Today on The Lab Report: 3:05 Meet Dr. Anurag Singh and learn about Urolithin A 6:45 Substrates, prevalence, and specific gut commensal bacteria 9:40 Mitophagy and mitochondrial health 12:55 Immunology and aging 15:35 Urolithin A and muscle mass 17:45 Academic research a-ha moments 20:15 Clinical benefits of Urolithin A 23:00 Food based approach vs. supplementation 25:25 Safety and contraindications 27:00 Ranking your supplement stack 29:10 The Fireball Additional Resources: Timeline Mitopure Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on X, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Health expert and Parsley Health founder Dr. Robin Berzin joins host Angela Foster to discuss a proactive approach to managing perimenopause and menopause. Dr. Berzin emphasises the importance of listening to our bodies, tracking whole-body symptoms over time using tools like the Parsley Symptom Index, and utilising continuous blood work to catch early hormonal shifts before standard symptoms like hot flashes begin. WHAT YOU'LL LEARN How to actively listen to your body and identify early, subtle signs of perimenopause before major symptoms like hot flashes even begin. How tracking whole-body symptoms and blood work over time reveals personalised hormonal trends that one-off lab tests completely miss. How optimising sleep consistency and monitoring heart rate variability (HRV) with wearables can lower your biological age and improve stress resilience. How a personalised combination of proactive lifestyle tracking, lab data, and tailored hormone therapies can naturally regulate your metabolism, mood, and energy levels. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

What if the reason you feel more tired, foggy, or just not like yourself anymore… isn't just hormones or “getting older” — but something happening deeper in your body? In this episode, I sit down with Jen Scheinman, a registered dietitian with over 25 years of experience in nutrition and healthy aging and Director of Science Communications at Timeline Nutrition. Jen is one of the leading educators on Urolithin A — a postbiotic compound found in Mitopure — and its role in mitochondrial health, cellular renewal, and longevity. Beyond Timeline, she also runs her own practice, Next Jen Health, where she helps women optimize vitality through the menopause transition and beyond. We explore a part of our health that most of us have never really been taught to think about—our mitochondria, the energy centers inside our cells — and why so many women start to feel a shift in their 30s and 40s, when the things that used to work suddenly don't. Jen breaks down the science in a way that actually makes sense, connecting fatigue, brain fog, and changes in your body to what's happening at the cellular level. We talk about why diet and exercise can stop working the way they used to, how your gut and environment impact your energy, and what's really going on beneath the surface as we age. We also explore the difference between living longer and actually feeling good while you do it — and what it looks like to support your body in a way that aligns with how it truly works. This conversation isn't about quick fixes. It's about understanding your body on a deeper level so you can start to feel like yourself again. Mitopure now starts at just $79. Go to ⁠timeline.com/healwithkelly to get 20% off Mitopure supplements and Skincare with code HEALwithKelly. Key Moments You'll Love ✨ :

Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) PT-141 / Bremelanotide [https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html) GHK-Cu copper peptide https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) Tretinoin / Retin-A https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html) NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/) Nicotinamide Riboside / NR https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/) Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/) GLP-1 drugs https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Tirzepatide https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html) BPC-157 https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/) TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/) Tesamorelin https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)   Thymosin Alpha-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/) SS-31 / Elamipretide https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/) Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html) Psyllium husk https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Why Isn't Everyone Talking About Mitochondria? with Jennifer Scheinman Most people learned the word in 10th-grade biology and never thought about it again. That, argues registered dietitian and longevity expert Jennifer Scheinman, is exactly the problem. In this episode of Why Isn't Everyone Doing This?, Emily Fletcher sits down with Jennifer, a nutritionist with over 25 years of experience and a longevity expert at Timeline, the company behind the clinically studied Urolithin A supplement MitoPure, for a conversation that reframes everything from fatigue to aging to consciousness through the lens of your cells. Jennifer explains how the mitochondria work, why their decline accelerates in your 40s and 60s, and what you can actually do to slow that process. They cover the 12 biological hallmarks of aging, the cellular recycling system (mitophagy) that breaks down over time, why so many people can't produce Urolithin A on their own, and how to evaluate supplements in an industry the FDA doesn't fully regulate. They also connect it all to meditation, to stress, to perimenopause, and to the Greek myth of Persephone and the pomegranate. And at the very end: a fact about mitochondrial DNA that changes the way you think about your mother, your grandmother, and the feminine line you carry. In this episode, they explore: – What mitochondria are, what they do, and why they're more like a CEO than a powerhouse – The cellular recycling process (mitophagy) and why it slows with age – Zombie cells, inflammaging, and the 12 hallmarks of biological aging – Why aging isn't linear — and what the research says about the 40s and 60s – How meditation reduces the inflammation driving cellular decline – Urolithin A: what it is, how your gut should be making it, and why most people's isn't – How to read supplement labels and avoid "fairy dusting" and borrowed science – Timeline's clinical research: what the trials showed and how long results take – The topical MitoPure skincare line and UV-related skin aging – Why mitochondrial DNA is inherited exclusively through the maternal line – Persephone, pomegranates, 108 seeds, and the convergence of myth and molecule Key Moments: 00:00 — The question that opens the episode 03:00 — Mitochondria 101: what they really are 08:15 — Every cell except red blood cells runs on mitochondrial energy 10:00 — Mitophagy: your body's cellular cleanup crew 13:00 — Why aging accelerates in the 40s and again in the 60s 16:00 — Zombie cells and the inflammaging hallmark 19:00 — Meditation's effect on cellular inflammation — the Ziva link 25:00 — Fasting and perimenopause: what the science says for women 29:00 — How to evaluate supplements when labels aren't regulated 35:00 — Urolithin A: gut-made, often missing, and why it matters 40:00 — Why food alone won't get you there (6 cups of pomegranate juice a day) 44:00 — The clinical trials: muscle endurance at 2 months, strength at 4 months 53:00 — Urolithin A + exercise: a likely additive effect 58:00 — How Dr. Gabrielle Lyon first put this on Emily's radar 01:01:00 — The skincare line: bringing MitoPure topically 01:03:00 — Mitochondrial DNA and the matrilineal inheritance 01:05:00 — Persephone, pomegranates, and the place where science meets spirit About Jennifer Scheinman Jennifer Scheinman is a registered dietitian and nutritionist with over 25 years of experience. She is a longevity and nutrition expert at Timeline, the company behind MitoPure — a clinically researched Urolithin A supplement backed by over $50 million in human studies. Her mission is making the science of longevity accessible, practical, and connected to how you actually feel. Follow Jennifer: @jenscheinmanrdLearn more: https://timelinenutrition.com This episode is sponsored by Timeline. Support your mitochondrial health and get 20% off Mitopure at http://timeline.com/ziva. ✨ The Portal is open. If this conversation stirred something in you — around energy, consciousness, and what becomes possible when your body is resourced — you may be ready for what's next. The Portal is Ziva's newest immersive experience, with a VIP weekend for those who want to go further. If you feel the pull, follow it.

Hydrogen water—breakthrough or scam? Osteoporosis fixes; Nattokinase for cardiovascular prevention; Why vitamin D helps a subset of diabetics; When oral vitamin D doesn't work, sublingual D may normalize blood levels; Vitamin D found beneficial for colitis; Why fructose stokes food cravings; Flawed fluoridation study claims no IQ harms to kids.

What if the key to looking and feeling 20 years younger wasn't another supplement stack, but something you could get for free, starting tomorrow morning? Liz Earle's biological age is over 20 years younger than her chronological age, and in this episode she breaks down exactly why. It comes down to three things most women in their 40s and 50s have never considered: circadian rhythm and the light you are exposed to, the water you are drinking, and the energy your cells are actually running on. If you are feeling tired, foggy, or like your body is aging faster than it should, this episode will change how you see your daily environment. WHAT YOU'LL LEARN • Why morning light fixes low energy, poor sleep, and hormone imbalance after 40 How indoor LED lighting damages your mitochondria and the simple swap that reverses it • Why sunscreen may be blocking the vitamin D and nitric oxide you need after menopause • How tap water disrupts hormones and energy and what to drink instead • What EZ water is and why it matters for mitochondrial energy and aging after 40 • Why mineral deficiency causes fatigue and brain fog in perimenopause • How grounding and circadian light slow visible aging from the inside out TIMESTAMPS: VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Angela presents a bitesize episode inn which she explores the physiological changes behind midlife weight gain, focusing on the role of cortisol and the hormonal shifts occurring during perimenopause.  They highlight how the decline and fluctuation of oestrogen and progesterone lead to a redistribution of body fat from the hips and thighs to the abdominal area, as the body transitions out of its fertile state WHAT YOU'LL LEARN Hormonal Fat Redistribution: During perimenopause, declining oestrogen levels signal the body to shift fat storage from fertile areas like the hips and thighs to the abdomen. Muscle Mass and Metabolism: Loss of lean muscle mass in midlife significantly slows metabolism, as muscle is a primary "metabolic organ" that consumes glucose and fat for energy. The Importance of Protein: Prioritising high protein intake and sufficient calories is essential for building and maintaining muscle, especially as it becomes harder to do so during perimenopause. GLP-1 Considerations: While GLP-1 medications can aid weight loss, they often suppress appetite so significantly that meeting necessary protein requirements for muscle preservation becomes a major challenge. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Full Show Notes: https://bengreenfieldlife.com/sisson2026 In this episode with Mark Sisson, you'll discover why VO2 Max may be overrated as the gold standard for longevity, and why chasing it cost Mark 32 pounds of muscle and the real-world function that actually matters. You'll explore his "Old Man Olympics" framework: a decathlete's approach to fitness at 72, spanning strength, speed, balance, and endurance. You'll also get his take on cold plunging, alcohol, biohacking, AI, and find out why foot health may be the single most overlooked lever in your longevity toolkit, from bunions to glute activation to big toe function. Mark Sisson ignited the ancestral health movement with Mark's Daily Apple and The Primal Blueprint, popularized keto and intermittent fasting with The Keto Reset Diet and Two Meals a Day, and sold Primal Kitchen to Kraft Heinz for $200M. He now runs Peluva, a toe-separated shoe company built around restoring foot strength and healthy gait, and is the author of Born to Walk.

More on “eat the rainbow” . . . or notMedical breakthroughs that we don't really needCan you discuss the order of eating macronutrients and its impact on blood glucose?What about the impact of apple cider vinegar on blood sugar?

Most women doing everything right in perimenopause still feel exhausted, foggy, and frustrated by belly fat that won't shift. This is not a willpower problem. It is an estrogen problem, and most women are being told to wait when they should be acting now. In this episode, I sit down with Dr. Robin Berzin, founder of Parsley Health, to explore why belly fat accumulates around the middle as estrogen shifts, why 43% of ADHD diagnoses in women hit between 41 and 50, and why estrogen loss drives brain fog and dopamine decline that most doctors are missing. Dr. Berzin also makes the case for starting hormone therapy early and shares what data from 120 million women tells us about HRT, dementia risk, and long-term protection for your brain, bones, and heart. WHAT YOU'LL LEARN • Why brain fog gets worse in perimenopause • The link between estrogen, dopamine, and focus after 40 • Why so many women are being diagnosed with ADHD in their 40s • The early signs of perimenopause  • How HRT reduce the risk of dementia and Alzheimer's in women • How low progesterone affects your sleep, skin, and mood • How to track perimenopause symptoms and labs over time • How magnesium helps with ADHD, anxiety, and sleep in perimenopause • How zone two cardio and yoga improve focus and brain function after 40 TIMESTAMPS: 00:00 What's Really Changing in Your Body After 40 06:33 Can You Skip HRT and Still Be Optimised After 40? 11:08 Does HRT Lower Your Dementia Risk? 14:00 Are You a Good HRT Candidate? How to Know and What to Track 23:19 What Your WHOOP Data Reveals About Perimenopause 28:16 Why ADHD Spikes in Your 40s: The Estrogen-Dopamine Link 33:46 Can't Focus After 40? The Exercise and Supplement Fix 40:17 How Weight Training Protects Your Brain After 40 45:02 Dr. Berzin's Daily Non-Negotiables for High Performance VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Belly fat in perimenopause isn't just about eating less and moving more — and if that's still the advice you're getting, this conversation is long overdue. Nurse practitioner and metabolic health expert Cynthia Thurlow breaks down the real drivers behind midlife body composition changes: muscle loss, declining insulin sensitivity, shifting hormones, a changing gut microbiome, and the one factor almost everyone overlooks — chronic stress and unresolved trauma. There's a fascinating deep dive into the estrobolome and how the gut processes and clears oestrogen, why fibre has become the most polarising word in nutrition, and what bitter greens have to do with your gallbladder. Practical, evidence-led and genuinely eye-opening. The good news? These changes are not permanent. There's a lot that can be done — and it starts with understanding what's actually going on. Informed, honest and packed with actionable insight for women navigating midlife health. 5 KEY TAKEAWAYS Belly fat in perimenopause has multiple root causes — muscle loss, declining oestrogen and testosterone, reduced insulin sensitivity, and a less diverse gut microbiome all play a role. Addressing just one without the others will only get you so far. The abdomen has 40 times more cortisol receptors than other areas of the body. Chronic stress — including unresolved childhood trauma — directly contributes to visceral fat accumulation and metabolic disease risk. The estrobolome — the part of the gut microbiome responsible for processing oestrogen — depends heavily on fibre intake. Without sufficient fibre, oestrogen gets recirculated rather than excreted, amplifying hormonal imbalance. Short-chain fatty acids, produced when gut bacteria ferment dietary fibre, are critical signalling molecules that reduce inflammation, protect the gut lining, and support the body's own natural GLP-1 production. Body composition changes in perimenopause are not inevitable or permanent. Practical steps — deep breathing before meals, nutrient-dense whole foods, adequate hydration, and addressing stress — can meaningfully shift outcomes. QUOTES "We have 40 times more cortisol receptors in our abdomen — so when someone says they went through a stressful period and noticed body composition changes, I understand physiologically exactly why that happens." "The gut is this main communicator with the rest of the body — when I think about how many things about body composition are impacted by gut health, it is literally everything." "If your body does not feel safe, that will absolutely contribute. Unresolved stress and trauma are not separate from metabolic health." "Fiber has become the new F word because it is very polarising — but if you look at the research, it is missing from most people's diets." "These do not have to be permanent issues. There are definitely things we can do to buffer up against the changes that are happening." VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

We tend to think of heart disease, cancer, and Alzheimer's as separate problems. But what if they all stem from the same underlying process? On this episode of The Dr. Hyman Show, I sit down with Dr. Eric Verdin, whose research, including work on compounds like urolithin A, is helping reshape how we think about aging and long-term health. We explore why aging may be the biggest driver of chronic disease and what that means for how you approach your health. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We unpack: • How your immune system becomes both overactive and less effective over time • What chronic inflammation is doing inside your body and how to start bringing it back into balance • Why cellular energy and mitochondrial health are key to repair and recovery • How your microbiome shapes inflammation, immunity, and long-term health • The daily habits that impact longevity most and where people get it wrong This conversation reflects a shift in how we think about health, moving beyond treating disease to understanding what's driving it in the first place. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, Seed, BIOptimizers, BON CHARGE, Paleovalley and Big Bold Health. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to paleovalley.com/hyman to save 15% off your first order today. Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order. (0:00) Biological age vs. cholesterol in heart disease and chronic disease risk (0:50) Introduction of Dr. Eric Verdin and his work (1:23) Sponsor: Brain Shaping Academy (1:51) Sponsor: Mitopure (2:54) Sponsor: Seed (3:48) Welcoming Dr. Eric Verdin and longevity framing (5:42) The geoscience hypothesis and modifying age as a risk factor (8:21) Early-stage interventions in aging and potential for life extension (9:56) Longevity skepticism and practical steps for today (11:20) Mitochondria, inflammation, and hallmarks of aging (17:20) Mitochondrial DNA, inflammation, and immune system aging (22:17) Innate vs. adaptive immunity and immune aging (28:47) Strategies to combat immune aging (33:07) Gut health, inflammation, and foundational elements of longevity medicine (38:20) Social connections, sociogenomics, and cellular energy in aging (46:29) Cellular repair systems and postbiotics (50:33) Sponsor: Paleo Valley (52:34) Sponsor: Big Bold Health (53:23) Urolithin A, immune rejuvenation, and longevity interventions (59:08) Longevity and functional medicine approaches (1:02:27) Big data, AI, and the evolution of medicine (1:04:26) Microbiome, diet, and gut health (1:06:14) Measuring biological age and biological clocks (1:09:37) Future of health monitoring and closing remarks

Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

Most women doing everything right in perimenopause still feel exhausted, foggy, and frustrated by belly fat that won't shift. This is not a willpower problem. It is an estrogen problem, and most women are being told to wait when they should be acting now. In this episode, I sit down with Dr. Robin Berzin, founder of Parsley Health, to explore why belly fat accumulates around the middle as estrogen shifts, why 43% of ADHD diagnoses in women hit between 41 and 50, and why estrogen loss drives brain fog and dopamine decline that most doctors are missing. Dr. Berzin also makes the case for starting hormone therapy early and shares what data from 120 million women tells us about HRT, dementia risk, and long-term protection for your brain, bones, and heart. WHAT YOU'LL LEARN • Why brain fog gets worse in perimenopause • The link between estrogen, dopamine, and focus after 40 • Why so many women are being diagnosed with ADHD in their 40s • The early signs of perimenopause  • How HRT reduce the risk of dementia and Alzheimer's in women • How low progesterone affects your sleep, skin, and mood • How to track perimenopause symptoms and labs over time • How magnesium helps with ADHD, anxiety, and sleep in perimenopause • How zone two cardio and yoga improve focus and brain function after 40 VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Dr. Mary Claire Haver, a board-certified obstetrician-gyneacologist, explores the physical and biological shifts women experience during perimenopause and menopause. She discusses the common issue of visceral belly fat and its health implications, emphasising the importance of an anti-inflammatory diet rich in fibre and whole foods over a weight-centric focus.  Dr. Haver also addresses digestive changes like bloating, linked to a shifting gut microbiome, and offers guidance on essential supplements such as Vitamin D, fibre, and creatine to support long-term health and muscle maintenance. WHAT YOU'LL LEARN The biological cause of belly fat: Understand how hormonal fluctuations during menopause lead to a natural shift in body composition and the accumulation of visceral fat. How the gut microbiome changes: Discover the relationship between menopause and digestive symptoms like bloating as the gut's bacterial profile begins to shift. Dietary strategies for hormonal health: Learn the benefits of an anti-inflammatory, plant-based diet and the specific role of fibre in managing menopausal symptoms. The role of key supplements: Identify which supplements, like Vitamin D, magnesium, and creatine, can effectively support health goals when paired with a balanced lifestyle. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Every question that came in over the last month. No filters, no shortcuts. This is the April 2026 edition of the solo Q&A and Hunter covers everything from women's hormone optimization and PCOS to vasectomy impacts on men's health, peptides for neurological conditions, bioregulator cycling protocols, and everything in between.For research and entertainment purposes only.0:00 — Intro & How Hunter Organizes Q&A Questions1:21 — Email List & Axion Collective2:17 — Category: Women's Health & Hormones2:21 — Kisspeptin Added to TRT — Does It Help Libido & Muscle for Women?3:43 — Free Testosterone Doubled on GHK-Cu But Feeling Nothing — Reduce HRT?4:39 — What Are Truly Optimal Estrogen & Testosterone Levels for Women?5:58 — Peptides for Women Focused on Health Optimization & Longevity6:41 — Deep Dive on PCOS for Women in Their Late Teens & Early Twenties7:44 — Can Peptides Help Bring Up a Low White Blood Cell Count?8:18 — No-Sting Reconstitution Water & GHK-Cu — Buccal Strips vs Injections11:03 — Category: Men's Health11:03 — Vasectomy Impact on Men's Health & Bioregulators Before & After12:05 — Hit a Plateau on Testosterone — What to Look at Next?12:28 — Best Peptides for Post Cycle Therapy13:33 — PEG-MGF for Real World Use as a Healing Peptide14:41 — Category: Specific Disease States14:50 — Peptide Protocol for Hepatitis C15:23 — Peptides That Help With High Blood Pressure16:28 — Myelin Regeneration & Protection for MS17:10 — FND Diagnosis After Ischemic Stroke — What Peptides Might Help?17:58 — Kidney Transplant & Anti-Rejection Meds — Peptides Worth Exploring?18:57 — Dihexa for Alzheimer's Protocols & Stacks19:35 — Urolithin A & P-21 for an 87-Year-Old With Neurodegenerative Issues20:25 — Amidated vs Non-Amidated P-21 — Does It Matter & How to Dose?21:27 — Does Retatrutide Count Toward the 15mg Weekly Tirzepatide Max?22:17 — Is Metformin Still the Best Longevity Compound?23:10 — Category: Performance & Mitochondrial Health23:15 — Are There People Who Don't Respond to MOTS-C?24:31 — L-Carnitine Timing Around Thyroid Meds & Does Glutathione Cause Gray Hair?25:53 — Had Great Results on 250mcg SLU — Go Higher or Diminishing Returns?26:51 — BAM-15 & SLU Dosing, Cycling & Peptide Refrigeration Shelf Life28:22 — Category: Growth Hormone Peptides28:30 — Optimal Tesamorelin Dose for Non-HIV Use, Stacking With Ipamorelin & Storage30:59 — MK-677 Deep Dive — Using It on Breaks From CJC & Ipamorelin32:05 — Anaphylactic Reactions to Sermorelin After a Year of Use — What Causes This?33:38 — GHK & AHK for Hair Loss, Gray Hair Reversal & Skincare34:32 — Category: Stacking Protocols34:38 — Guidelines for Introducing & Stacking Peptides — Protocol or Symptom Based?36:01 — SLU-PP-332 Pills vs Injection — Which Is Better?36:24 — Best Practice for Reconstituting Ara-290 for Chronic Neuropathy37:20 — Could Thymosin Alpha-1 Trigger a Negative Immune Response & Spike CRP?38:33 — Yearly Bioregulator Cycling Protocol Document40:51 — Closing Thoughts & Thank You

New-think on diet for ApoE4, a risk factor for Alzheimer's—eat meat! Is a non-invasive blood sugar monitor on the drawing board for the next Apple Watch? True or false—does drinking carbonated water help weight loss? Eating while distracted puts on the pounds; Treating duodenitis; How much whey protein should you consume? Why some people fail to lose weight on GLP-1 drugs.

When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong.It's actually your immune cells suffocating on toxic waste because their power plants—your mitochondria—are breaking down.In this video, I explain the exact biological mechanism behind "immune aging" and why your body's natural cleanup system (mitophagy) stalls out in your 40s and 50s. More importantly, I'm sharing the breakthrough compound scientists discovered that actually reverses this. It's a molecule called Urolithin A, originally found in pomegranates.I dive into the massive problem with trying to get this molecule from food (only 30% of people have the right gut bacteria to even make it), and the 15 years of human clinical trials behind Mitopure—the supplement that bypasses your gut completely. I even share why I spent $100,000 on an extreme T-cell procedure before I knew I could just take this to get a younger immune system in 28 days.00:00 – Immune Decline After 4000:39 – Why Immune Cells Weaken01:17 – The Role of Mitochondria02:25 – Mitophagy & Its Decline05:45 – The Ancient Fruit: Pomegranates06:39 – The Problem With Pomegranates07:19 – Urolithin A as a Supplement08:33 – Trial Results09:58 – About MitoPure10:46 – Call to ActionThank you to our sponsors!-GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what's in your air.-Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVEConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Full Show Notes: https://bengreenfieldlife.com/nadplus In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology. You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD. You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging. Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.

Dr. William Li explores the fascinating science of brown fat, a specialised type of fat that acts like a cellular furnace to burn off harmful visceral fat. He reveals how a simple daily habit, like eating a single ripe tomato an hour before lunch, can trigger this fat-burning mode, potentially shrinking waistlines and reducing inflammation.  From the historical discovery of brown fat in hibernating animals to modern breakthroughs in PET scan technology, Dr. Li explains how we can use elemental eating and cold exposure to optimise our metabolism and reclaim our health. WHAT YOU'LL LEARN Eating one ripe tomato a day, particularly an hour before lunch, has been shown to activate brown fat and can lead to a reduction in visceral fat and waist circumference. Brown fat is packed with mitochondria that burn fuel to generate heat, especially when activated by certain foods or cold temperatures. Tomatoes are rich in bioactives like lycopene and beta-cryptoxanthin, which are absorbed into the bloodstream and directly fire up brown fat cells. Returning to a diet of whole, unprocessed foods allows the body to take full advantage of its natural metabolic hardware. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

You used to digest everything. Now a salad wrecks you. If perimenopause changed your gut overnight, this one's for you.Andrea Donsky, nutritionist, published menopause researcher, menopause educator, author, and co-founder of wearemorphus.com sits down with nurse practitioner and bestselling author Cynthia Thurlow to unpack the gut-hormone connection nobody warned us about. Cynthia's brand new book, The Menopause Gut (out April 28), is the paradigm-shifting guide to why 94% of perimenopausal women suddenly have digestive issues, and what to actually do about it.What you'll learn:Why you can't digest food properly if you're stressed (and the 4-breath trick that changes it)What the estrobolome is and how it's recycling your estrogen in ways that make bloating worseThe fiber mistake that's making your gut feel worse, not betterWhy your gut suddenly looks more like a man's after menopauseHow PCOS and perimenopause collide (and why it's not "over" when your period stops)The difference between intermittent fasting and "digestive rest" and which one works better in midlifeChapters:0:00 Cynthia's Morocco Story: When Perimenopause Broke Her Gut 2:10 Why Gut Health Gets Worse in Perimenopause and Menopause 6:32 Digestion Starts in the Brain: The Parasympathetic Connection 11:10 Estrogen, Histamine, and Why You Suddenly React to Foods 15:58 Postbiotics 101: Butyrate, Urolithin A, and Short-Chain Fatty Acids 21:30 Fiber, Bloating, and Why You Can't Just Jump to 30 Grams a Day 26:15 The Gut-Bone Connection Nobody Talks About 29:58 Sleep, Stress, and the Cortisol-Constipation Loop 34:42 The Vagus Nerve: Your Gut-Brain Superhighway 39:00 Intermittent Fasting vs Digestive Rest: What Changed Her Mind 42:50 PCOS, Insulin Resistance, and Menopause: The Missing Conversation 46:40 Where to Find Cynthia and The Menopause Gut Book

Women's gut is not just a digestive organ. In perimenopause, it is the control centre for your hormones, your mood, your weight, and your brain. If you are bloated, exhausted, gaining weight around your middle, this episode explains what is actually happening in your gut during perimenopause and what you can do to fix it.  WHAT YOU'LL LEARN • Why is my gut health getting worse in perimenopause? • Why am I suddenly bloated all the time after 40? • What causes food sensitivities in perimenopause? • Does leaky gut cause weight gain in menopause? • How does cortisol cause belly fat in women over 40? • Does HRT improve gut health and the microbiome? • The link between anxiety, mood swings, and gut health in perimenopause • How fibre helps with oestrogen balance and bloating after 40 • What is TUDCA and should women in perimenopause take it? • What causes fatigue and low energy in perimenopause?   TIMESTAMPS 00:00 The Link Between Gut Health & Perimenopause 12:27 Why Anxiety Gets Worse in Perimenopause 19:04 Why Women Lose Energy After 40 and How to Get It Back 29:00 The Real Reason Belly Fat Increases in Perimenopause 36:04 Fiber and the Estrobolome: The Key to Balancing Estrogen After 40 41:46 Sudden Food Sensitivities After 40? This Is What's Happening in Your Gut 50:16 What Causes Bloating in Perimenopausal Women 55:16 Does HRT Help Your Gut Microbiome in Menopause? 01:04:39 The Health Habits That Keep High Achieving Women Thriving After 40 VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Angela is joined by Sarah Berry to talk about the complex relationship between visceral fat and insulin resistance, particularly during the menopause transition. They discuss how these two factors influence each other in a cyclical manner, making it challenging to pinpoint a clear starting point for weight gain and metabolic issues. They highlight the various symptoms women experience during menopause, such as anxiety, mood swings, and poor sleep, which can hinder motivation for healthy eating and physical activity WHAT YOU'LL LEARN There is a complex relationship between visceral fat and insulin resistance, where each can exacerbate the other, creating a circular process that complicates weight management during menopause. Common symptoms during the menopause transition include anxiety, mood swings, depression, brain fog, and poor sleep, which can negatively impact motivation for healthy eating and physical activity. The loss of oestrogen during menopause leads to changes in fat distribution, shifting fat storage from the hips to the abdomen, which is associated with increased visceral fat. Postmenopausal women experience poorer metabolic responses to carbohydrates, leading to higher blood sugar levels and increased hunger, which can result in consuming more calories throughout the day. It is important for women to show kindness to themselves and support each other through the menopause transition, as many experience similar challenges and changes in their bodies. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

CEO of large hospital system makes controversial call to replace radiologists with AI; Inclusion Body Myositis—is it curable? New worries over flame retardants in recycled black plastic utensils; Scientists discover link to toxic microbiome byproducts in causation of ALS, frontotemporal dementia; When depression-sufferers lose all interest in food; Eating plenty of fresh fruits and vegetables incurs risk of bio-accumulation of pesticide residues; Tattoos carry long-term health risks.

Expect a renewed push to take a statin at your next doctor's visit; PREVENT online calculator skews decisions to prescribe cholesterol reduction as early as 30; American Heart Association discourages at-risk patients from taking fish oil and garlic supplements—REALLY? Renewed interest in muscle as promoter of overall health and metabolism; The key role of urolithin A (Mitopure®️) for supporting muscle function. Is DHEA a reasonable supplement for post-menopausal women?

Most women in perimenopause assume their energy crash is a sleep or a stress problem. Jen Scheinman, Head of Nutrition Affairs at Timeline, explains what the real reason is, and why estrogen loss makes it dramatically worse for women than men. If you have been doing everything right and still feel like you are running on empty, this episode explains what is actually happening at the cellular level, and what women in midlife can do about it. WHAT YOU'LL LEARN • Why women's energy levels drop faster in perimenopause? • When does mitochondrial decline start and how fast does it progress? • What is Urolithin A and why can't you get enough from food? • What is mitophagy and why does it matter for energy after 40? • Does Urolithin A build new mitochondria or just clear out damaged ones? • What is the right dose of Urolithin A and does timing matter? • Can Urolithin A reduce fine lines and improve skin in perimenopause? • What does the research say about Urolithin A and immune aging? • Should you take Urolithin A as a supplement and use it topically? • Can Urolithin A help with brain fog after 40? VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

In Part 2 of this AMA, Vanessa answers your most asked questions on protein, fat loss, muscle, and metabolism — including digestion issues, emotional eating, protein myths, and how to optimize your intake for better body composition results.

Heart Association clashes with RFK, Jr., doubles down on recommendation for low-fat diets; Why the evidence for meat and full-fat dairy avoidance is weak; What are the health benefits of circumcision? The ultimate weight loss plan—the Boring Diet; Substituting famotidine for PPIs for reflux; Midlife vitamin D curbs Alzheimer's risk; Natural support for polymyalgia rheumatica; What teens eat could be affecting their mental health.

Perimenopause isn't the waiting room for menopause. It is its own biological storm. Here's what it does to your body, and exactly what to do about it. In this episode I'm joined by Dr. Mary Claire Haver, board-certified OB-GYN and Menopause Society certified practitioner, and we break down exactly why women in this transition feel like they've lost themselves and how to get back and live their best life. WHAT YOU WILL LEARN • Why do you feel fine one day and awful the next in perimenopause • What is the "zone of chaos" and why your brain feels it first • Why anxiety, brain fog and sleep disruption are the first signs of perimenopause • Does estrogen work better than antidepressants for mood • When to start hormone therapy and where to begin • How long can you stay on HRT • Why belly fat increases in perimenopause and how to address it • How the gut microbiome changes through the menopause transition • Which supplements actually help women over 40: creatine, vitamin D, fiber and more • What vaginal estrogen does and why most women need it VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

What if stress isn't something to eliminate—but something to optimize? In this episode of Marni On The Move, Marni is joined by Dr. Sharon Bergquist, MD—physician, scientist, Associate Professor, Emory University, and author of The Stress Paradox—to explore how stress impacts the body, mind, and long-term health. From the biology of stress and recovery to the role of hormetic stressors, mitochondrial health, and mental resilience, this conversation reframes stress as a powerful tool for building resilience, improving performance, and supporting longevity. We also chat about Urolithin A as it relates to Mitochondria health and longevity. Dr. Bergquist also shares the inspiration behind her book, her personal journey, and how aligning stress with purpose and meaning can fundamentally shift how we experience challenge and growth. Dr. Sharon Bergquist, MD, is a physician, researcher, and expert in lifestyle medicine. She is the author of The Stress Paradox, where she explores how stress—when properly understood and applied—can be a powerful tool for improving health, resilience, and longevity. Whether you're an endurance athlete, high performer, or simply looking to better understand your health, this episode offers a fresh perspective on how to work with stress—not against it. Topic Outline The inspiration behind The Stress Paradox Understanding the difference between “good stress” and chronic stress The biology of stress and recovery at a cellular level Hormetic stressors and how small, intentional challenges build resilience Mitochondrial health, mental health, and their connection to stress and longevity The importance of recovery, sleep, and adaptation How to listen to and better understand your body's response to stress Understanding stress and its long-term impact on health Reframing your mindset around stress The power of purpose and aligning challenges with meaning Finding meaning through challenge, personal growth, and resilience Pushing boundaries, stepping outside your comfort zone, and building mental resilience Practical, simple strategies to support resilience and longevity The journey of writing the book, including personal growth and key reflections CONNECT Dr. Sharon Horesh Bergquist aka The Good Stress Doctor on Instagram Marni On The Move Instagram, TikTok, LinkedIn, or YouTube` Marni Salup on Instagram and Playlist on Spotify SUBSCRIBE TO OUR NEWSLETTER Sign up for our monthly newsletter, Do What Moves You, for Marni on the Move updates, exclusive offers, invites to events, and exciting news! SUPPORT THE PODCAST Leave us a five stars and a review on Apple, it’s easy, scroll through the episode list on your podcast app, click on five stars, click on leave a review, and share what you love about the conversations you’re listening to. Tell your friends the episodes you are listening to on your social. Share a screen shot of the episode in your stories, tag us, we will tag you back!

Full Show Notes: bengreenfieldlife.com/lnannette/ In this "Best of LIFE Network" episode with Annette Verpillot, you'll explore a neuromechanical approach to improve communication between your brain and your body, targeting the compensatory movements and postural adaptations that hold you back from pain-free, efficient movement. Annette is the founder of Posturepro (use code BOUNDLESS to save 15% off), a health company specializing in restoring the brain-body connection through some of the world’s most advanced rehabilitation and injury prevention techniques. Additionally, she actively works with clients, professional athletes, trainers, practitioners, researchers, and law enforcement officers to develop solutions that promote a healthy, long, and pain-free life. Annette actively participates in research on posture, health, and performance, and her recent collaboration with McGill University was presented at Harvard Medical School and La Sorbonne University in Paris. Episode Sponsors: Organifi Shilajit Gummies: Harness the ancient power of pure Himalayan Shilajit anytime you want with these convenient and tasty gummies. Get them now for 20% off at organifi.com/Ben. BON CHARGE: BON CHARGE is a holistic wellness brand with a wide range of products that naturally address the issues of modern life. Their products can help you sleep better, perform better, recover faster, balance hormones, reduce inflammation, and so much more. Go to boncharge.com/GREENFIELD and use coupon code GREENFIELD to save 15%. Formula IQ: Recuperate IQ by Formula IQ is a comprehensive copper supplement designed to support mitochondrial energy, iron balance, and metabolic health by pairing bioavailable copper with essential cofactors your body needs for proper utilization, which is especially crucial if you've been under chronic stress or supplementing with high-dose zinc. Try it at formulaiq.com and use code BEN for 10% off. Timeline: Give your cells new life with high-performance products powered by Mitopure, Timeline's powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging. Mitopure now starts at $79, when you go to timeline.com/BEN. Just Thrive: Just Thrive Probiotic is the only probiotic clinically proven to arrive 100% alive in your gut, wrestling in less bloat, better energy, and even clear skin. Digestive Bitters packs 12 science-backed herbs in one tasteless capsule that jumpstarts your digestion and supports GLP-1 production so cravings don’t control you. Visit justthrivehealth.com/BEN and save 20% with promo code BEN. See the difference for yourself or get a full product refund, no questions asked.See omnystudio.com/listener for privacy information.

In this episode, Dr. Jockers dives into the incredible benefits of pomegranates, a biblical fruit that supports gut health, improves circulation, and boosts fat burning. Learn how the unique polyphenols in pomegranates help reduce inflammation and promote heart health. Discover the power of oleic acid found in pomegranates, which rejuvenates mitochondria, strengthens the gut lining, and enhances fat metabolism. Dr. Jockers explains how this compound can support a healthier, more resilient gut. The episode also covers the benefits of anthocyanins in pomegranates, which improve leptin signaling, reduce cravings, and assist in weight management. Tune in to learn how pomegranates can transform your health. In This Episode:  00:00 Leptin and Anthocyanins 00:27 Show Intro and Resources 03:09 Biblical Fruit Reveal 04:33 Heart Shape and Polyphenols 05:36 Ellagitannins and Urolithin A 07:47 Anthocyanins and Quercetin 09:23 Five Gut Layers Explained 16:05 Blood Pressure and Fat Burning 18:24 Cancer and Skin Benefits 19:43 How I Eat Pomegranate 21:27 Cutting and Eating Tips 22:52 Supplements Juice and Dosage 25:24 Wrap Up and Outro   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com -  https://renewyourhair.com/drjm/DRJ.   If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relight from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relight helps restore hydration, improve energy, and support mental clarity. Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today!     "Pomegranates are packed with unique polyphenols that heal the gut, improve circulation, and boost fat burning." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources:   Reignite hair growth with AnaGain Nu, risk-free with a 180-day guarantee and a buy-one-get-one-free deal!  RenewYourHair.com/drjm/DRJ Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Why protein + ketones reduce hunger, how fat-adapted athletes perform without carbs, and what this new study reveals. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode, Vanessa breaks down one of the most controversial and important new papers in metabolism and sports nutrition with Dr. Andrew Koutnik. From fat loss to performance, this conversation challenges long-held beliefs about protein, carbohydrates, ketosis, and metabolic flexibility—and what actually drives results. If you've ever struggled with hunger, fat loss plateaus, or confusion around carbs vs keto… this episode will change how you think about fueling your body. The In This Episode • Why higher protein intake may accelerate fat loss • The powerful protein + ketone combo for appetite control • Why fat loss can feel effortless on low-carb, high-protein approaches • What's really happening with insulin, glucagon, and hunger hormones • Why you don't need high ketones to get results • How PSMF (protein-sparing modified fasting) drives rapid fat loss • The key difference between dietary fat burning vs body fat burning • Why calorie deficits increase hunger—and how to work around it • The shocking finding: carbs may NOT be required for performance • What 100+ years of research actually shows about carb loading • Why fat-adapted athletes can perform just as well • The real performance driver: brain energy, not muscle glycogen • Why some high-carb athletes may show prediabetic glucose levels • How to find your optimal carb vs fat intake for fat loss and performance

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimCresset family office services for CEOs, founders, and entrepreneurs: CressetCapital.com/TimTimestamps:[00:00:00] A meditative start.[00:02:19] Reflecting on our second Zen retreat in Santa Fe with Henry Shukman.[00:04:08] Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge.[00:08:06] “Just be still” — three simple words that miraculously shut down my OCD.[00:13:54] Is meditation secretly vagus nerve stimulation?[00:20:17] DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip.[00:24:57] HeartMath and watching your HRV move in real time.[00:27:57] Marching toward 50: balance boards and the end of jiu-jitsu.[00:31:26] Tony Hawk snowboarding Hokkaido with screws in his hip.[00:33:01] Slacklining and why your nervous system needs sleep cycles.[00:35:19] Bertolotti's Syndrome: My six-year back pain gets a name.[00:37:09] The nerve block test: everything wrong, zero pain.[00:44:10] Abrahangs tendon protocol: 10 seconds on, 50 off.[00:46:24] The NUG: a pocket hangboard for travelers.[00:48:31] Craig Mod's Japanese toothbrush and Toaster's cameo.[00:50:45] Kevin's $92 vintage fire jacket: Blue Heritage Japan.[00:54:26] Podcast picks: The Power Broker and STEM Talk.[00:56:20] Alzheimer's: A plaque or mitochondrial problem?[00:57:30] 10 grams of ketones turns one-word answers into sentences.[00:58:40] Methylene blue on Amazon: 120 years of research, zero guardrails.[01:02:36] Bredesen Protocol, APOE genotyping, and a cognitive comeback.[01:05:32] Photobiomodulation: $30k laser to the forehead.[01:07:55] Urolithin A and the high price of mitochondrial upkeep.[01:14:56] Recipe for disaster pants: espresso + creatine + MCT oil.[01:17:39] Norwegian 4×4 training and lactate as a brain lever.[01:23:15] Blood flow restriction bands and schwantz ring koans.[01:29:08] Hummingbirds named Sunset and squirrel obstacle courses.[01:32:06] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Full Show Notes: bengreenfieldlife.com/younggoose2026 In this episode, I’m joined by Amitay Eshel—the “engineer of beauty”—as we unlock the science behind glowing, healthy skin. We cover breakthrough topics like how your skin produces real light, how mitochondrial health impacts skin radiance, and the secrets to reversing aging using topical methylene blue (without staining!), NAD boosters, and platelet-derived exosomes. Learn my three-step protocol to support skin vitality: boosting mitochondrial function, using powerful stimuli like red light therapy and enzymatic scrubs, and guiding repair with advanced biologics. Plus, discover real solutions for bags under the eyes, cellulite, wrinkles, and scars. If you’re ready to biohack your skincare routine and elevate your confidence, dive in! For show notes, product links, and more, visit BenGreenfieldLife.com. Subscribe for potent tips and insights to help you look and feel your best! Amitay Eshel is Co-Founder of Young Goose and host of the Biohacking Beauty podcast. He helped pioneer at-home red light therapy and brought topical NAD+ precursors, spermidine, methylene blue, quantified exosomes, and DNA repair enzymes into consumer skin science. Go to: Young Goose and use code BEN10 to save 10% Episode Sponsors: Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Timeline: Give your cells new life with high-performance products powered by Mitopure, Timeline's powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging. Go to timeline.com/BEN for up to 39% off your Mitopure Gummies. Our Place: Upgrade to Our Place today and say goodbye to forever chemicals in your kitchen. Go to fromourplace.com/ben and enter my code BEN at checkout to receive 10% off sitewide. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at get.sunlighten.com/ben with code BEN. See omnystudio.com/listener for privacy information.

Depression and anxiety is so often linked to your gut. In this episode of the Ancient Health Podcast, Dr. Motley gives us a primer on the connection between your mood and C.diff's effect on your neurotransmitters and, crucially, what you can do about it.  Dr. Motley's Recommendations OATS Test - Mosaic Labs https://mosaicdx.com/test/organic-acids-test/ Morinda Supreme (Noni) - https://tinyurl.com/4fv49sts Melia Supreme (Neem) - https://tinyurl.com/mr3bmkfj Golden Thread (Chinese Coptis) - https://tinyurl.com/52c6n7wr Artemisia - https://tinyurl.com/47ppr39b Cryptolepis - https://tinyurl.com/3bnedtkv BodyGuard Supreme (Chanca Piedra) - https://tinyurl.com/be27akw2 DesBio Homeopathics - https://tinyurl.com/bdsbpa9u ------  Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. Follow Dr. Motley! Instagram Facebook Tik-Tok Website ------  * Learn more about Urolithin A supplementation at Timeline.com/DRMOTLEY and use promo code DRMOTLEY for up to 39% off Mitopure gummies!  *Join Doctor Motley's newsletter for TCM insights and regular podcast updates: https://www.doctormotley.com/ *If you want to hear more on how Chinese Medicine connects the physical and emotional, check out Doctor Motley's membership, complete with courses, a whole library of video-based resources and the chance to pick his brain on weekly live Q+A's. You can try it free for 15 days here: https://www.doctormotley.com/15