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Walk-Män-Podcast Episode 227: Ironman trotz MS – mit DanielGenau genommen feiert er in Kürze ein besonderes Jubiläum: Daniel (kompletter Name der Redaktion bekannt) erhielt 2006 nach seinem wahrscheinlich zweiten "Schub" die Diagnose "MS", sprich Multiple Sklerose. Die Multiple Sklerose (MS) oder Encephalomyelitis disseminata (ED) ist eine chronisch-entzündliche neurologische Autoimmunerkrankung mit sehr unterschiedlichen Verlaufsformen, weshalb sie auch als die „Krankheit mit tausend Gesichtern“ bezeichnet wird (Quelle: Wikipedia). Den jungen und engagierten Ehemann und Vater traf dieses Schicksal unvorbereitet und mit voller Wucht, Lebenspläne gerieten ins Wanken. Ein Arbeitskollege nahm ihn schließlich mit ins Fitnessstudio und Daniel merkte sofort, "wie gut mir das tut". Aus konsequentem Training und einer Ernährungsumstellung kam Daniel über Umwege zum Triathlon (2013). Nach diversen Kurzstrecken und Olympischen Distanzen wagte er sich 2017 erstmals an einen (kompletten) Ironman, dem viele weitere folgten. Reichlich Bewegung und bewusste Ernährung haben sein Leben zwischenzeitlich deutlich zum Besseren gewandelt und Daniel hat die Krankheit im Griff. Im Podcast-Gespräch nimmt er Zuhörer und Zuschauer mit auf die spannende Reise vom Couch-Potatoe mit heftiger Diagnose zum Langstreckensportler. Kontakt DanielWeb: linktr.ee/IronmantrotzmsWeb: https://www.leben-mit-ms.de/artikel/2023-01-11/daniel-44-vereint-sport-und-msInstagram: ironman_trotz_msWalk-Män – Der Mutmach- und Motivier-Podcast. Runter kommen von der Couch, Hindernisse überwinden und Ziele erreichen - unabhängig von Alter, Umfeld, oder Barrieren im Kopf. Wieder Lust bekommen auf‘s Leben. Podcaster und Journalist Ralf Baumgarten stellt inspirierende Persönlichkeiten und ihre Geschichten bzw. Projekte vor. Er selbst stellt sich immer wieder und regelmäßig eigenen Challenges sportlicher Art oder einfach nur, um den eigenen Horizont zu erweitern, neue Erfahrungen zu sammeln und die wenige Zeit auf Erden nicht zu verschenken. Der Walk-Män-Podcast: Lust auf‘s Leben, runter von der Couch kommen und gesund leben in Bewegung. Zu Podcaster Ralf Baumgarten: Redakteur, Mediengestalter, Herausgeber und Podcaster. Zusätzliche Ausbildungen (u.a.): Triathlon- und Lauf-Trainer, Yoga-Lehrer (200), Waldbademeister, Kommunaler Gesundheitsmoderator u.v.m. Kontakt Ralf Baumgarten:EMail: info@printhouse24.de / walkmaenpodcast@gmail.comWeb: https://mein-blaettche.deWeb: https://walkmaen.de/LinkedIn: https://www.linkedin.com/in/ralf-baumgarten-796287a1/Instagram: https://www.instagram.com/ralf_baumgarten/Sprecherin Einleitung: Christina Schmitt / TRIGA - der VerlagCover (Grundentwurf): Marek Bereta Lizenz Hintergrundmusik: PremiumBeat_license_2912638_3467091_those-mornings(1)Wichtig: Wenn Dir gefällt, was Du hörst, dann teile den Podcast und abonniere ihn beim Audio- oder Video-Streaming-Dienst Deiner Wahl. Toll wäre ein Feedback direkt an mich und (und) eine Bewertung auf dem jeweiligen Streaming-Dienst. Und last not least: Rückwärtshören oder -ansehen auf dem Walk-Män-Kanal macht Sinn - hier gibt es noch sehr viele spannende, unterhaltsame und informative Aufnahmen zu entdecken. Bleib wach, gesund und aufmerksam, Dein Ralf Baumgarten
In this episode, Dr. Chris Mortensen discusses the spread of fly-borne diseases in horses, including the examples of West Nile virus and African horse sickness. Dr. Mortensen reflects on his personal experiences during the COVID-19 pandemic and draws parallels with the rapid spread of diseases among horses. The podcast covers the transmission methods, signs, symptoms, and preventative measures for various diseases. Additionally, he emphasizes the importance of good barn management, vaccination, and consulting with veterinarians to protect horses from these potentially deadly illnesses. Key diseases highlighted include Equine Infectious Anemia, Vesicular Stomatitis, and different types of Encephalomyelitis. Podcast Timeline 00:00 Introduction to Fly-Borne Diseases 00:31 Personal Experiences and COVID-19 02:07 African Horse Sickness and Modern Transport 04:37 Historical Pandemics and Modern Implications 05:23 Global Movement of Horses and Disease Prevention 06:51 Understanding Fly-Borne Diseases 07:34 Transmission and Symptoms of Fly-Borne Diseases 10:12 West Nile Virus: A Case Study 13:04 Equine Infectious Anemia (EIA) 25:29 Preventing EIA and Other Fly-Borne Diseases 26:42 African Horse Sickness: A Global Threat 28:29 Global Spread of African Horse Sickness 29:27 Transmission and Impact of Midges 31:17 Forms and Symptoms of African Horse Sickness 33:05 Treatment and Prevention Strategies 35:15 Vesicular Stomatitis: A Regional Concern 38:19 Encephalomyelitis and West Nile Virus 41:41 Effective Barn Management Practices 48:06 Conclusion and Further Resources Visit https://madbarn.com/mad-about-horses/ to learn more about the Mad About Horses podcast. --------------------------------- Mad Barn Academy is dedicated to supporting horse owners, handlers and practitioners through research, training and education. Visit us to learn more at https://madbarn.com You can also find Mad Barn at: Instagram @madbarnequine Facebook @madbarnequine TikTok @madbarnequine YouTube @madbarn We would love to hear from you! Please send any questions or comments to podcast@madbarn.com
In this episode, we review the high-yield topic of Acute Disseminated Encephalomyelitis (ADEM) from the Neurology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.31.505712v1?rss=1 Authors: Godfrey, W. H., Hwang, S., Gharibani, P., Abramson, E., Kornberg, M. D. Abstract: Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS). Although classically considered a demyelinating disease, neuroaxonal injury occurs in both the acute and chronic phases and represents a pathologic substrate of disability not targeted by current therapies. Nitric oxide (NO) generated by CNS macrophages and microglia contributes to neuroaxonal injury in all phases of MS, but candidate therapies that prevent NO-mediated injury have not been identified. Here, we demonstrate that the multifunctional protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is robustly nitrosylated in the CNS in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. GAPDH nitrosylation is blocked in vivo with daily administration of CGP3466b, a CNS-penetrant compound with an established safety profile in humans. Consistent with the known role of nitrosylated GAPDH (SNO-GAPDH) in neuronal cell death, blockade of SNO-GAPDH with CGP3466b attenuates neurologic disability and reduces axonal injury in EAE independent of effects on the immune system. Our findings suggest that SNO-GAPDH contributes to neuroaxonal injury during neuroinflammation and identify CGP3466b as a candidate neuroprotective therapy in MS. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Dr. Magnus Boesen discusses his abstract, "Magnetic Resonance Imaging Criteria at Onset to Differentiate Pediatric MS from Acute Disseminated Encephalomyelitis". Show references: https://index.mirasmart.com/aan2022/
Krissy Dilger of SRNA was joined by Dr. Farrah Mateen and Dr. Cindy Wang for an Ask the Expert Podcast on "Acute Disseminated Encephalomyelitis (ADEM): Diagnosis and Treatment Guidelines." The experts begin by providing an overview of ADEM, including a brief definition, signs and symptoms in the acute phase, and potential causes. The physicians then discuss diagnostic tests and how other disorders are ruled out. They talk about acute treatments and long-term care for people with ADEM. Finally, the experts provide information on research being conducted on ADEM.
Victoria Arlen is a television personality for ESPN, as well as an actress, speaker, model, and former American paralympian swimmer. Victoria's life drastically changed in 2006 at the age of eleven when she developed two rare conditions known as Transverse Myelitis and Acute Disseminated Encephalomyelitis. This was an incredibly rare scenario and Victoria quickly lost the ability to speak, eat, walk and move. She slipped into a vegetative state in which doctors had written her off as a lost cause. Victoria spent nearly four years “locked” inside her own body completely aware of what was going on just unable to move or communicate. Doctors believed there was little hope of survival and recovery was unlikely. Victoria, however, was not ready to give up. In 2010 after almost four years, she began the nearly impossible fight back to life. Learning how to speak, eat and move all over again.
Acute disseminated encephalomyelitis (ADEM) is a rare, monophasic autoimmune condition affecting the brain and spinal cord. The symptoms of ADEM can be variable, given that lesions can present in multiple areas of the central nervous system. ADEM shares certain clinical characteristics with other demyelinating conditions such as pediatric multiple sclerosis and transverse myelitis, but it also has important defining characteristics. To learn more about this condition, John and Ryan speak with Lana Harder, Ph.D., ABPP-CN, who is a founding member and current Co-Director of the Children's Medical Center Pediatric Demyelinating Disease Clinic. Show notes are available at www.NavNeuro.com/73 _________________ If you'd like to support the show, here are a few easy ways: 1) Get APA-approved CE credit for listening to select episodes: www.NavNeuro.com/INS 2) Tell your friends and colleagues about it 3) Subscribe (free) and leave an Apple Podcasts rating/review: www.NavNeuro.com/itunes 4) Contribute to the discussion in the comments section of the website (click the episode link listed above) or on Twitter (@NavNeuro) Thanks for listening, and join us next time as we continue to navigate the brain and behavior! [Note: This podcast and all linked content is intended for general educational purposes only and does not constitute the practice of psychology or any other professional healthcare advice and services. No professional relationship is formed between hosts and listeners. All content is to be used at listeners' own risk. Users should always seek appropriate medical and psychological care from their licensed healthcare provider.]
Corina Duyn joins us all the way from Ireland! She is a writer, artist and puppet designer whose work is reflected by nature and her life with a chronic illness, myalgic encephalomyelitis. Corina shares the deeply personal journey of how she has transformed her pain through puppetry into poetry. Follow her on Instagram @corinaduyn www.corinaduyn.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.28.224709v1?rss=1 Authors: Wang, Z., Wang, L., Zhong, F., Wu, C., Hou, S.-T. Abstract: Although substantial evidence supports smoking as a risk factor for the development of multiple sclerosis (MS) in adulthood, it remains controversial as to whether early-life exposure to environmental tobacco smoke (ETS) increases the risk of MS later in life. Here, using experimental autoimmune encephalomyelitis (EAE) as an animal model for MS, we show that exposing neonatal rats during the 1st week (ETS1-EAE), but not the 2nd week (ETS2-EAE) and the 3rd week (ETS3-EAE) after birth, increased the severity of EAE in adulthood in comparison to pups exposed to filtered compressed air (AIR-EAE). The EST1-EAE rats showed a worse neurological deficit score and a significant increase in CD4+ cell infiltration, demyelination, and axonal injury in the spinal cord compared to AIR-EAE, ETS2-EAE, and ETS3-EAE groups. Flow cytometry analysis showed that the ETS1 group had decreased numbers of regulatory T (Treg) cells and increased effector T (Teff) cells in the brain and spinal cord. The expressions of Treg upstream regulator Foxp3 and downstream cytokines such as IL-10 were also altered accordingly. Together, these findings demonstrate that neonatal ETS exposure suppresses Treg functions and aggravates the severity of EAE, confirming early-life exposure to EST as a potential risk factor for multiple sclerosis in adulthood. Copy rights belong to original authors. Visit the link for more info
Alex Howard shares a mini-documentary with Simon Limpus, the first employee of the Optimum Health Clinic. The story includes how Simon went from living with ME/CFS alone in a caravan at the end of his parent's garden, to doing a 2500km motorbike challenge across Siberia after making a full recovery.
Alex Howard talks to Liarne 10 weeks on from their first session and she talks about the progress she has made, and they discuss how much activity she should now be doing. Watch Liarne's first session, Understanding why the body shuts down, at https://youtu.be/cLg9ATrMvww
Alex Howard works with Luci for a second session. With Luci having made significant progress with her ME/CFS since the previous session 6 months ago, they talk about how to protect that progress, and then how to help accelerate it. Watch Luci's first mini-session at https://youtu.be/thONLD7Ygxs
Alex Howard talks to The Optimum Health Clinic Chairman David Butcher about his journey of recovery from ME/CFS and the role that being diligent and consistent played in it. Watch the Secrets to Recovery Movie with the Free Information Pack - just go to www.theoptimumhealthclinic.com and submit your request.
Alex Howard talks to Kirsty Cullen (Director of Nutrition at the Optimum Health Clinic) about core principles of the OHC approach to nutrition.
Returning to the body | Everyday Alex 059 | Feel Good Friday Alex Howard talks to Carol about her current experience on the RESET Program and the power of learning to reconnect to her body.
Mindful Monday | Everyday Alex 055 | Alex Howard offers a simple guided meditation to help relaxing more deeply into the body.
Soul-food Sunday - Everyday Alex 049 - Alex Howard talks to George about the critical role that yoga played in helping process trauma and PTSD in his recovery from ME/CFS.
When our primary symptom is fatigue, it's clear that getting deep, effective rest is a crucial part of the recovery process. When the maladaptive stress response adds too much stress to be able to relax deeply, we can intend to rest without actually achieving deep rest. The OHC approach works to calm the nervous system enough that the tired/wired process surrenders to legitimate relaxed restful states. At stage 1 we need to prioritise deep rest, in stage 2 we need more activity to calm and ground the new energy anxiety, and at stage 3 people find it easier to get deep rest when they're able to do more physical activity.
Alex talks about people pleasing as a habit of the helper type that puts other peoples' needs before our own. Becoming aware of the pattern and its impact is the beginning of changing the behavior. If you go to great lengths to avoid conflict or get your self-worth from doing things for other people, you might find it worthwhile to explore this pattern in yourself. Understanding this pattern as a helper type with ME/CFS can help us avoid over-extending our energy in unhelpful ways. Use the sensitivity you have to sense what other people need and turn that around now on to yourself to sense what you need.
In this Facebook Live recording CEO Alex Howard discusses getting moving without pushing in ME, CFS and Fibromyalgia recovery. The Achiever subtypes particularly can get caught up in over-doing patterns, so we need a new way to approach to break old habits and cultivate new helpful habits. Setting new goals versus recognising the achiever pattern is that a healthy mindset will make our new goal feel good, the achiever pattern mindset will feel like pressure. Recognising the healthy approach to a new goal is important so that we don't end up doing something out of force or pushing through when we don't have the wellness to accomplish something.
David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Psychology Practitioner Marie Fleming talks about how to bring in a sense of enjoyment to your day during the recovery process, even though illness can be so challenging and uncomfortable. Being able to create a moment of enjoyment can relieve a little bit of suffering, without just trying to pretend to be happier.
OHC practitioner Marie discusses creating healthy boundaries, especially in relation to helper subtypes. Being able to say no to people or to tasks when we need to prioritise our own healing process is an important lesson in creating healthier relationships and making sure we're setting ourselves up for recovery.
What allows us to feel calm, confident, and embodied is making peace with the sense of uncertainty, making peace with not knowing what's going to happen. Alex talks about developing confidence and a sense of safety in the body versus trying to intellectualise solutions for potential challenges. Stress and worry use up energy that we need to heal - and in ME CFS and Fibromyalgia we need to remove any unnecessary energy drains in order to build up our systems.
Ignoring our wants and needs can lead our minds and bodies to continually get louder until we finally listen and pay attention to what is currently happening. Making space for and being mindful of our thoughts, feelings, emotions, and symptoms can actually calm the system down because it doesn't need to trigger the maladaptive stress response to get our attention. Becoming aware of our thoughts and symptoms is the first practice in learning how to understand our bodies and learn how to best respond next.
In this Facebook Live recording CEO Alex Howard discusses the 4 fundamentals of recovery from ME, CFS and Fibromyalgia from which to keep track of the recovery journey and build tools to move forward. 1. Do we have a baseline? (activity levels, pacing, a place from which to build) 2. Are we making progress over time? (Less crashes, more ups, quicker recoveries) 3. Protect the progress! 4. Accelerate the progress by tackling various symptoms or co-morbidities
After discussing what is possible from recovery, and exploring things that may help someone recover from ME CFS, some people have a rejection or resistance to the idea that recovery is possible. It can be devastating to get your hopes up, which is why some people choose instead not to believe in recovery from ME CFS and Fibromyalgia. Contributing to this is the stigma and misinformation about the illness to begin with, and therefor an inability to begin to understand how to solve the problem. Alex discusses the importance of realising that recovery can include everything from improving quality of life to a full remission of symptoms, and that there is still too much unknown to state that every single person can recover. The Optimum Health Clinic seeks to solve as many pieces of the ME CFS puzzle under control to ease symptoms, take the load off the body, and support the body's natural healing abilities to improve quality of life.
It can be a real challenge to commit to future plans when we're still working on our recovery from ME CFS or Fibromyalgia. Alex offers some tips about how to handle social commitments when you really don't know if you'll be well enough to attend.
In this short Facebook Live session, Alex explains the importance of making recovery the most important goal in your day to day life, especially in the early stages. If we have multiple goals or priorities it can put our health in a back seat when we should be making choices that are best for our body and recovery. Are you giving your recovery the priority it needs for it to be the thing that progresses and moves in your life?
The advice, "listen to your body" sounds like it should be easy, but it isn't quite as simple as it seems. We often get conflicting messages from our body and it can be tricky to decide which message to listen to. Alex offers advice on how to make the next best informed decision based on all the information available.
Becoming familiar with and identifying thoughts of our energy-depleting "inner critic" can be huge in helping us identify unhelpful thought patterns or beliefs that we can stop and change. Changing the tone of our inner mental chatter to one that is positive and caring can free up emotional energy and help us make better choices. Alex also offers some tips on how to handle the inner critic once you recognise it.
The mental pattern of Windows ME means we run every thought and activity through the filter of having ME. This means every situation can cause stress if we continually question what the future holds for us which can increase the constant maladaptive stress response. At stage 1 Windows ME can help us find our boundaries, but beyond that it can start to cause problems.
Mental tennis is a mental pattern that can make decision making feel impossible. In ME/CFS our nervous systems are already over-stimulated, and when it comes to deciding how to spend our energy, patients can feel stuck in a tug-of-war over how to move forward and make the "right" choice. Alex offers some tips on how to recognise and address mental tennis to get clarity on making a choice in the moment with mindfulness and checking-in in a new or different way.
Alex discusses why patients in the nutrition program can benefit from also doing the psychology work with The Optimum Health Clinic. We do not in any way promote the idea that ME/CFS or Fibromyalgia are psychological illnesses, but that chronic illness is both difficult, stressful, and at times traumatising, and that ME/CFS in particular causes over-arousal, over stimulation, and the maladaptive stress response. Our psychology work can help reduce the stress load and calm the nervous system and help take the load off of the immune system.
The recovery path can take so much discipline and organisation that we can sometimes forget that a balanced life includes play, fun, and joy. Alex talks about finding a balance between our Helper/Acheiver/Perfection types and our childlike inclinations for enjoyment. Recovering from ME/CFS and Fibromyalgia can feel like serious business, and remembering to introduce playful activities can really help on the journey to wellness.
We now know that approaching healing from ME CFS from a "pushing" motivation can make everything worse, so willpower for recovery in ME CFS and Fibromyalgia needs a new meaning. Pushing to work harder and do more will not work for recovering from these illnesses, but we may need determination in other ways to find acceptance and allow ourselves to rest and take steps to get into a healing state. Willpower on the recovery path is doing LESS, to stop doing something you want to do when what you need to do is stop and rest.
Alex explores the psychological subtypes (Anxiety, Achiever, Helper) that can play a part in remaining ill with ME CFS, and how noticing these patterns can help us put ourselves first and notice the thought behaviours that are unhelpful in our recovery. Beyond recovery from ME CFS, understanding psychological subtypes will help us to grow and evolve throughout our lives in various challenging circumstances. Psychological subtypes aren't unique to chronic illness, and the work we put into understanding our own inner critic and neurosis will help us well into healthy life.
When we start making some progress on our journey, the recovery process can feel incredibly slow and we start to wonder what exactly is possible from recovery from ME, CFS or Fibromyalgia. Alex explains that you do not need to be perfect biologically or psychologically in order to recover - and you can easily underestimate what is possible in the long term.
Alex Howard discusses deep rest in ME, CFS and Fibromyalgia recovery. The maladaptive stress response in MECFS keeps the nervous system wired, and mindful rest can help us recover the parasympathetic nervous system. Noticing our personality patterns can help us recognise when we aren't allowing for deep rest when our mind wants us to push through and overexert.
In this Facebook Live recording CEO Alex Howard discusses being methodical: taking time when starting new supplements, treatments, or movements in order to see what is helping on the road to recovery from ME, CFS and Fibromyalgia.
In this Facebook Live recording CEO Alex Howard discusses how the maladaptive stress response can keep us in a state where we are unaware of what our body really needs. Being able to relax into your exhaustion can take practice, but being able to deeply rest is necessary for healing to take place.
The Helper subtytpe in the Optimum Health Clinic model is one type of characteristic that can be looked at in terms of habits and beliefs that may contribute to becoming or staying ill with ME, CFS or Fibromyalgia. Exploring self-worth and supporting the self can be helpful tools to practice to overcome unhealthy helper patterns.
In this Facebook Live recording CEO Alex Howard discusses gratitude and comparing ourselves to others. While being able to acknowledge our loss and difficulty is an important part of being in our body, it is also an extremely useful practice to be grateful for what we do have and the things that are working here and now.
Alex Howard discusses SOFA HEROES: Because you have to be a superhero to live with ME, CFS or Fibromyalgia. The Sofa Heroes fundraising campaign will raise money for our double-blind study with the University of Surrey on the effectiveness of The Optimum Health Clinic Method for ME/CFS and Fibromyalgia in order to make the treatment available through the NHS or covered by insurance. See how you can start a Sofa Heroes campaign at https://www.theoptimumhealthclinic.com/fundraising/ Read about the proposed study at https://www.theoptimumhealthclinic.com/case-for-support/
Alex discusses the limitations of psychological approaches and miracle recovery stories from psychological therapies for ME, CFS and Fibromyalgia. Through the Optimum Health Clinic, the patient gets both psychological support to encourage healing, and also functional medicine to look at various biological systems that may be out of balance. Exploring the Lightning Process and Mickel Therapy and Reverse Therapy, EFT and more, and their places in some parts of recovery, Alex explains how they can help with parts of the puzzle, but is not the full picture for the broadest patients with ME CFS.
Alex describes the slippery slope of self-medicating or taking supplement advice from non-professionals. With personalised care from The Optimum Health Clinic, a nutritionist can help you discover exactly which supplements will be most helpful for your specific needs.
What we need when the going is challenging and difficult, is support, inspiration, and motivation - and there are few situations as challenging as living with ME/CFS and Fibromyalgia. Alex discusses various ways of cultivating inspiration with the help of practitioners or self-inspired resources. Watch The Secrets to Recovery Movie at http://www.secretstorecovery.com/movie/
On the verge of the release of the Secrets to Recovery film, Alex reflects on the process of recovery from the patients that have been interviewed, and also the process of making a film - in that these projects take teamwork and collaboration. ME/CFS can feel like a very lonely journey, but Alex encourages being aware of all the members of your team helping you on your path to recovery.
When we've invested so much hope and energy into various methods in an effort to recovered, it can be challenging to try new approaches. The Optimum Health Clinic takes a look at all various stages of recovery and can help you develop a personalised plan for sustainable health.
While filming patients for the latest Secrets to Recovery documentary, Alex is reminded of the perserverance and hope that patients and family members have on the journey to recovery. Watch the film at http://www.secretstorecovery.com/movie/
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode Articleby Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal (virology blog) Lightning process (virology blog) Letter to Parliament (virology blog) Crowdfunding is not conflict of interest (virology blog) Open letter to Lancet 3.0 (virology blog) Mayo still champions GET (virology blog) Image Credit Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS. Hosts: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode All of David's ME/CFS articles at virology blog David Tuller on Twitter Through the Shadowlands by Julie Rehmeyer Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Open Forum on Acute Disseminated Encephalomyelitis
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Learning About Acute Disseminated Encephalomyelitis
Rare Genomics / RareShare Podcast Series: Ask the Expert & Patient Navigation
Rare Genomics Institute RareShare Ask the Expert:Podcast Series, Disease Specific Q&A Sessions, For feedbacks contact, Scientific Director, Rare Genomics Institute: Deepa Kushwaha, deepa.kushwaha@raregenomics.org (Music credit: www.bensound.com)
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06
Tue, 15 Oct 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/16189/ https://edoc.ub.uni-muenchen.de/16189/1/Koutrolos_Michail.pdf Koutrolos, Michail ddc:570, ddc:500, Fakultät für Biologie
Francisco Javier Carod-Artal discusses a Review concerning the neurological complications of dengue virus infection.
Hosts: Vincent Racaniello and W. Ian Lipkin Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus. Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Multicenter blinded analysis of CFS and XMRV/pMLV (mBio) Press release on multicenter study (pdf) Press conference webcast TWiV on Facebook Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06
This study investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease course of secondary progressive MS, albeit in a strongly abbreviated time course (Figure 3.1.1). This study demonstrates that MOG-specific autoantibodies are responsible for initiating clinical relapse and driving disease progression. On the background of mild, sub-clinical inflammatory activity in the CNS, pathogenic antibodies enter the CNS and mediate demyelination, a process that in turn amplifies the local inflammatory response (Figure 3.1.14 A). It should however be noted that lethal clinical relapses may also occur in the absence of a pathogenic antibody response if an inflammatory lesion develops in a region of the CNS that is particularly sensitive to damage, or where it may perturb vital functions, such as the brain stem. Although antibodies have been shown to amplify the severity of ongoing clinical EAE (Schluesener et al., 1987; Linington et al., 1988; Lassmann et al., 1988), firm evidence for a role in driving relapse and disease progression was missing. This study has now established this principal, which in all probability is relevant to our understanding of the pathogenesis of severe, steroid non-responsive relapses in MS patients. However, this model of EAE is an artificial system, in which the role of antibody is only apparent because of the different kinetics of MOG-specific T and B cell responses. In MS we still have to answer two crucial questions, namely the identity of the autoantigens targeted by the demyelinating antibody response, and the factors that may trigger this response. MOG is the only myelin protein known to initiate a demyelinating antibody response in EAE, and MOG-induced EAE has provided a valuable tool to identify the role of pathogenic autoantibodies in immune mediated demyelination. However, there is a major discrepancy between the proportion of MS patients with pathogenic MOG-specific antibodies in their circulation (5%; Haase et al., 2000) and the frequency of patients with pathological changes suggestive of antibody-mediated pathomechanisms (>50%; Lucchinetti et al., 2000). This discrepancy may in part be accounted for by the absorption of the pathogenic antibodies into the CNS, which will lead to a dramatic reduction of the antibody titre in the periphery, as demonstrated in section 3.1.3.4 of this study. On the other hand, it is unlikely that MOG is the only target autoantigen, which is exposed on the myelin surface and can therefore initiate a demyelinating autoantibody response. The identification of potential targets is a prerequisite to develop diagnostic kits to identify those patients with pathogenic autoantibody responses and then provide an appropriate therapy such as plasma exchange, or immuno-absorption. As demonstrated in this study, DNA vaccination using a plasmid encoding a myelin antigen is one approach to generate high titre autoantibody responses directed against the native protein. The pathogenicity of this antibody response can then be assayed in the same animal by inducing EAE. This method circumvents problems such as purity, yield and denaturation, all of which complicate any study using antigens isolated from the CNS or generated using recombinant technologies. Coupling this approach to a proteomics based analysis of the myelin membrane and reverse genomics to identify candidate gene products provides the means to map out those protein antigens that can be targeted by a demyelinating autoantibody response. The feasibility of this concept is currently being tested in the rat using PLP and MAG as myelin components that may in certain circumstances provoke a pathogenic autoantibody response. Such an analysis will, however, not detect pathogenic antibody responses to glycolipid antigens, which are major target autoantigens in a number of diseases affecting the peripheral nervous system such as Guillain Barré syndrome (GBS). In GBS a pathogenic antibody response to gangliosides appears to be triggered by infections with particular serotypes of Campylobacter jejuni (Fredman, 1998; Willison and O´Hanlon, 1999). In the majority of patients these antibody responses are an acute phenomenon and disappear as the patients recover (Hahn, 1998). It is conceivable that a similar mechanism is responsible for the initiation of severe relapses in some MS patients, if an infection triggers a cross-reactive antibody response to a surface glycolipid epitope. This would induce an episode of acute CNS demyelination that would not be immediately responsive to immunosuppressive therapy, as tissue damage and amplification of the local inflammatory response would be driven by the pre- existing antibody response. Analysis of the autoantibody responses in MS should therefore be extended to examine lipid as well as protein autoantigens. Such studies should also not be restricted to myelin, but also address the question of responses to other structures such as the axon and oligodendrocyte progenitor cells. Such autoantibody responses are however only conditionally pathogenic, in other words their pathogenic potential is only expressed if they can enter the CNS across the blood brain barrier (BBB)(Litzenburger et al., 1998; Bourquin et al., 2000). In EAE the inflammatory insult to the CNS is responsible for the disruption of BBB function and the entry of antibody into the nervous system. MS is characterised by repeated episodes of CNS inflammation but what initiates and maintains this response is unclear. The observation, that DA rats develop a similar, although eventually self-limiting response in the CNS after immunisation with MOG-peptide in CFA provides a model to investigate the immuno-regulatory deficit(s) responsible for chronic CNS inflammation. The disease model is very reproducible with >90% of animals relapsing after peptide immunisation as opposed to
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.10.033662v1?rss=1 Authors: Fournier, A. P., Baudron, E., Wagnon, I., Aubert, P., Vivien, D., Neunlist, M., Bardou, I., Docagne, F. Abstract: Clinical observations support the hypothesis that stressful events increase relapse occurrence in multiple sclerosis patients, while stress-reduction strategies can modulate this effect. However, a direct cause-effect relationship between stress level and relapse cannot be firmly established from these data. The purpose of this work was to address whether modulation of stress could interfere with symptom relapse in an animal model of multiple sclerosis with relapsing-remitting course. We report that repeated acute stress induced a twofold increase in relapse incidence in experimental autoimmune encephalomyelitis. On the other hand, environmental enrichment reduced relapse incidence and severity, and reversed the effects of repeated acute stress. These data provide the platform for further studies on the biological processes that link stress and multiple sclerosis relapses in a suitable animal model. Copy rights belong to original authors. Visit the link for more info
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