Branch of medicine studying the immune system
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3 episodes with immunobiology
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2 episodes with immunobiology
What is long COVID? What are the signs of long COVID? Does getting COVID multiple times increase long COVID risk? What long COVID treatments are available? Akiko Iwasaki, PhD, Sterling Professor of Immunobiology at Yale University, discusses new long COVID research, emerging treatments for long haul COVID, and the latest from the Yale Long COVID clinic. American Medical Association CXO Todd Unger hosts.
Dr. Wilfried Ellmeier is a Co-Chair of the Scientific Planning Committee at the International Union of Immunological Societies (IUIS) and Professor of Immunobiology and Head of the Institute of Immunology at the Medical University of Vienna. Dr. Laurence Zitvogel is a Keynote Speaker at IUIS 2025 and a Professor and Group Leader at Gustave Roussy. Dr. Dan Littman is also a Keynote Speaker at IUIS 2025 and Professor of Cell Biology and Helen L. and Martin S. Kimmel Professor of Molecular Immunology at NYU Langone. This episode features a discussion on the upcoming IUIS 2025 Congress taking place August 17-22 in Vienna, Austria. They talk about what to expect at the meeting, highlights from this year's program, and where to explore in Vienna.
This week, Jonathan is joined by Dr Shahram Kordasti, Associate Professor in Applied Cancer Immunopathology at King's College London, UK. In this episode, Dr Kordasti discusses the immunobiology of Myelodysplastic syndrome and Aplastic anaemia, the role of CD4+ T cells in myeloid malignancies, and how cutting-edge computational tools are enhancing treatment strategies. Timestamps: (00:00)-Introduction (01:23)-Hodgkin's lymphoma origin (04:21)- Immunobiology of diseases (08:55)-Plasticity of T cells (13:42)-Computational biology and multiomics for patient stratification (21:00)-Standardising immune monitoring (25:41)- Pretreatment with systemic agents (27:55)- Myeloproliferative neoplasms (31:48)-Synthetic data generation (36:22)-Exciting developments on the horizon (39:16)-Three wishes for healthcare
In this mini-series, we explore different health professions to better understand the variety of team members involved in patient care. For this episode, we spoke with Anh Phu about his journey to becoming a physician-scientist. Anh Phu is an MD-PhD student at the Yale School of Medicine. He was born in Vietnam and moved to San Francisco, CA at 11. He attended City College of San Francisco and transferred to the University of California, Berkeley, where he received his Bachelor of Arts with/ Honors in Molecular & Cell Biology in 2019. Anh then worked as a research assistant at UCSF and the San Francisco VA Center studying the roles of macrophages in cardiometabolic diseases. He has published three first-author articles in prestigious scientific journals that further contribute to understanding the metabolic reprogramming of macrophages to regulate chronic inflammation and atherosclerosis. Anh also co-authored numerous publications that investigated the functional properties of extracellular vesicles in atherosclerosis, obesity, diabetes, sepsis, and cancer. He is now a 3rd year student and just recently joined the Department of Immunobiology at Yale to begin his PhD work. His scientific interest focuses on understanding the effect of aging on the immune system and cardiovascular diseases. This also translates to his clinical interest, which he aspires to pursue a career in cardiovascular medicine. As an immigrant himself, Anh is also passionate about immigrant health. He volunteers at the HAVEN Free Clinic, where he helps provide primary care services to immigrant patients in New Haven. Episode produced by: Deborah Chen Episode recording date: 10/13/2024 www.medicuspodcast.com | medicuspodcast@gmail.com | Donate: http://bit.ly/MedicusDonate
In this episode, I interviewed Dr. Michael Johnson, an Associate Professor of Immunobiology and Associate Dean for Basic Science Research and Graduate Studies in the College of Medicine at the University of Arizona. He is also the Director of the National Summer Undergraduate Research Project (NSURP), the program that helped me recruit the first two guests I've ever had on this podcast! Check out NSURP here.
Dr. Jeffrey Rathmell is the Cornelius Vanderbilt Professor of Immunobiology at the Vanderbilt Center for Immunobiology. His research focuses on T cell metabolism in cancer. He talks about what T cells use for fuel and his work on fatty acid synthesis. He also discusses the 'obesity paradox' in cancer immunotherapy and his favorite parts of being a scientist and professor.
Dr. Susan Kaech is a Professor and Director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute. Her lab aims to understand how memory T cells are produced during infection and vaccination, how they function, and why they can fail to induce long-term immunity, particularly during chronic disease or cancer. In this episode, she talks about her research on T cell exhaustion and neuroimmunology, as well as her path from genetics to immunology.
Hello there!In this episode of The Dairy Podcast Show, Dr. Corwin Nelson, an associate professor at the University of Florida, shares his expertise on the crucial role of vitamin D in dairy cattle health. Dr. Nelson discusses the impact of vitamin D on calcium regulation, immune function, and overall animal health, providing insights into the prevention of milk fever and subclinical hypocalcemia. Tune in to explore the latest research and practical applications in the dairy cattle industry."We've realized that Vitamin D does much more than regulate calcium and phosphorus. It's crucial for tissue development, immune function, gut physiology, and reproductive health."What you'll learn:(00:00) Highlight(01:46) Introduction(06:04) Research focus on vitamin D(10:14) Importance of vitamin D in dairy cattle(13:17) Understanding subclinical hypocalcemia(20:19) Feeding strategies with vitamin D(30:49) Long-term outcomes of vitamin D supplementation(42:26) Final three questionsMeet the guest: Dr. Corwin Nelson is an associate professor of physiology at the University of Florida, focusing on enhancing cattle health and productivity. He earned his Ph.D. in Biochemistry and Immunobiology from Iowa State University and completed a postdoctoral fellowship at the University of Wisconsin-Madison. His research primarily investigates the role of vitamin D in the immune response of dairy cattle, emphasizing mastitis. With extensive experience in both teaching and research, Dr. Nelson contributes significantly to sustainable cattle farming practices.The Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo- Acepsis- SmaXtec- Protekta- Trouw Nutrition- dsm-firmenich- Volac- Diamond V- Berg + Schmidt- Natural Biologics- ICCAre you ready to unleash the podcasting potential of your company? wisenetix.co/custom-podcast
Today, we're excited to bring you the first episode in a special Raise the Line series that Osmosis from Elsevier has created in partnership with the Cohen Center for Recovery from Complex Chronic Illnesses (CoRE) at the Icahn School of Medicine at Mount Sinai Hospital. PAIS: Root Causes, Drivers, and Actionable Solutions is a ten-part examination of a range of post-acute infection syndromes such as long COVID, tick-borne illness, chronic fatigue syndrome, and connective tissue disorders. Your host, Dr. Raven Baxter, a molecular biologist and Director of Science Communication at CoRE, will be joined by an impressive array of specialists in the field to explore causes, symptoms, diagnoses and treatments, as well as the devastating impact on patients who often struggle for many months or even years with a troubling span of symptoms affecting everything from muscle movement to mental health. As you'll learn in the series, diagnostic protocols are lacking for many of these conditions, leading to delayed treatment and prolonged suffering for patients. In this inaugural episode, Dr. Baxter is joined by microbiologist Dr. Amy Proal, CEO of the PolyBio Research Foundation; Yale University Professor of Immunobiology, Dr. Akiko Iwasaki; and Dr. Edward Breitschwerdt, Professor of Medicine and Infectious Diseases at North Carolina State University College of Veterinary Medicine who will discuss the Building Blocks of PAIS.Mentioned in this episode: Mount Sinai Health System Steven & Alexandra Cohen Foundation
Akiko Iwasaki, Ph.D., is a Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University, and an Investigator of the Howard Hughes Medical Institute. She received her Ph.D. from the University of Toronto in Canada and her postdoctoral training from the National Institutes of Health. Her research focuses on the mechanisms of immune defense against viruses at the mucosal surfaces, and the development of mucosal vaccine strategies. She is the co-Lead Investigator of the Yale COVID-19 Recovery Study, which aims to determine the changes in the immune response of people with long COVID after vaccination. Dr. Iwasaki also leads multiple other studies to interrogate the pathobiology of long COVID, both in patients, and through developing animal models of long COVID. Dr. Iwasaki was elected to the National Academy of Sciences in 2018, to the National Academy of Medicine in 2019, to the European Molecular Biology Organization in 2021, and to the American Academy of Arts and Sciences in 2021.
What causes long COVID? Is long COVID dangerous? Who is most likely to get long COVID? Any pediatric long COVID news? What can be done for long term COVID? Our guest is Akiko Iwasaki, PhD, Sterling Professor of Immunobiology at Yale University. American Medical Association CXO Todd Unger hosts.
Nearly one in four adults who contracted COVID-19 have developed long COVID symptoms, according to the latest Census report. This hour, Dr. Akiko Iwasaki, an immunobiology expert at Yale who is focused on researching long COVID, joins us to share what we know and don't know about the illness, and the many ways it can manifest. The Patient-Led Research Collaborative has authored several seminal surveys and studies. We also hear from co-founder Lisa McCorkell about this bank of patient-led research. She says, "We need a moonshot for long COVID: at least a billion dollars a year in research funding to adequately address this crisis." Plus, Yale American Studies professor Dr. Daniel HoSang has written about the “twin pandemics” of COVID-19 and racism. He joins us to reflect on the four-year mark of the virus, and the links he sees to the long COVID response. GUESTS: Dr. Daniel HoSang: Professor of American Studies, Yale University; Co-Author, Under the Blacklight: The Intersectional Vulnerabilities that the Twin Pandemics Lay Bare Dr. Akiko Iwasaki: Co-Lead Investigator, Yale COVID-19 Recovery Study; Sterling Professor of Immunobiology, Yale University School of Medicine; Investigator, Howard Hughes Medical Institute Lisa McCorkell: Co-Founder, Patient-Led Research Collaborative Support the show: http://wnpr.org/donateSee omnystudio.com/listener for privacy information.
Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists. Francisco Gomez-Rivera is an Immunology Program Graduate Student Candidate at the University of Michigan, and Dr. Jason (Swinburne) Augustine is a retired Research Microbiologist/Immunologist at the US Environmental Protection Agency. They talk about the upcoming IMMUNOLOGY2024™ meeting in Chicago, Illinois from May 3-7, 2024. They discuss key sessions to attend, what they're looking forward to at the meeting, and advice for attendees.
Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists (AAI), and Dr. Aimee Bernard is an Assistant Professor of Immunology and Microbiology at the University of Colorado. Dr. Iwasaki has a very active presence on X, where she shares about COVID-19 research. Dr. Bernard is also active on social media through her TikTok account, and co-hosts a podcast, Help! Make It Make Sense. In this episode, they discuss the importance of communicating science to the public and strategies for social media. They also talk about how the AAI is working to share immunology knowledge with non-scientists through Immunology Explained.
In September 2012 Arctic sea ice melted to its minimum ever recorded and the German research ice breaker, Polarstern, ventured deep into the region North of Russia to record findings. It's now retracing its steps, over a decade later, to observe how things have progressed. Autun Purser and Antje Boethius describe the journey and the importance of documenting developments in the face of climate change. Some 75 million individuals are believed to live with Long Covid and, in order to treat the plethora of symptoms presented by patients, researchers continue to search for the root source of the condition in the hope of better prescribing broad therapeutics. Akiko Iwasaki, Professor of Immunobiology at Yale University, updates Roland on the working hypotheses. And one year on from the Hunga Tonga eruption, where a shockwave circled the globe four times, researchers have been able to calculate the speed of the currents in the southern Pacific Ocean. BBC correspondent Jon Amos caught up with Michael Clare to hear how other South Pacific Islands can learn from the most explosive volcanic eruption in 100 years. Presenter: Roland Pease Producer: Harrison Lewis
Dr. Felicia Goodrum, Ph.D. ( https://profiles.arizona.edu/person/fgoodrum ) is Interim Associate Department Head and Professor of Immunobiology, as well as Professor, BIO5 Institute, Cellular and Molecular Medicine, Molecular and Cellular Biology, Cancer Biology And Genetics Graduate Interdisciplinary Programs, at the University of Arizona. Dr. Goodrum earned her Ph.D. from Wake Forest University School of Medicine studying cell cycle restrictions to adenovirus replication and then trained as a postdoctoral fellow at Princeton University in the laboratory of Dr. Thomas Shenk studying human cytomegalovirus latency. Dr. Goodrum joined the faculty at the University of Arizona in 2006, and her long-standing research focus is to understand the molecular virus-host interactions important to human cytomegalovirus (CMV) latency and persistence in the host. She has focused on identifying viral and host determinants mediating the switch between latent and replicative states. The goal of her research program is to define the mechanistic underpinnings of HCMV latency and reactivation to lay the foundation for clinical interventions to control CMV disease in all settings. Dr. Goodrum is the recipient of the Howard Temin Award from the National Cancer Institute, the Pew Scholar in Biomedical Sciences Award, and the Presidential Award for Early Career Scientists and Engineers. Support the show
Akiko Iwasaki, a Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University, with a particular interest in mucosal infection, is making gains in Long Covid research. Her work with Dr David Putrino (interviewed in Episode 47) revealed several findings that move us closer to identifying a bio-marker; her work with Michele Monje of Stanford University looked at the chief mechanisms that may be driving the neurological features of Long Covid; now, in collaboration with Harlan Krumholz, they are leading a study into the efficacy and safety of Paxlovid in Long Covid.And her Yale LISTEN study to understand Long Covid, post-vaccine adverse events and the corresponding immune responses is recruiting now.Distilling some of her remarkable knowledge into a very digestible form, you do not want to miss this episode.Living with Long Covid? How was your week?Website - https://www.tlcsessions.net/Twitter - @SessionsTlc https://twitter.com/sessionstlcInsta - @tlcsessions https://www.instagram.com/tlcsessions
Dr. Kate Rhodes and Dr. Melissa Herbst-Kralovetz are researchers at the University of Arizona Health Sciences, looking at how the vaginal microbiome relates to gonorrhea and bacterial vaginosis. In this episode, Dr. Kate and Dr. Melissa talk to Brittany all about STI rates in the US, the impacts for women, the link between the vaginal microbiome and cancer, plus what it's like to be a researcher of women's health. Enjoy the episode!Guest biosDr. Kate Rhodes is a Research Scientist at the Tucson Arizona Campus in the Department of Immunobiology., where her work is focussed on the complex interactions between infection-causing pathogens and the bacteria that live in the body. Dr. Kate is working to understand bacterial adaptation in the female reproductive tract. Dr. Melissa Herbst-Kralovetz is an Associate Professor at College of Medicine Phoenix at the University of Arizona, in both the Department of Basic Medical Sciences and Obstetrics & Gynecology. Dr. Melissa has her own laboratory, currently studying the relationship between vaginal dysbiosis and HPV persistence, progression and carcinogenesis, endometrial cancer and other gynecologic sequelae.Company bioThe University of Arizona Health Sciences is one of the top-ranked academic medical centers in the southwestern United States. The University of Arizona Health Sciences includes the College of Medicine (Phoenix), College of Medicine (Tucson), College of Nursing, Mel and Enid Zuckerman College of Public Health, and the R. Ken Coit College of Pharmacy.The Herbst-Kralovetz research lab is broadly interested in understanding innate mucosal immune responses to resident bacteria, STI pathogens (e.g HPV, HSV), and microbial products at mucosal sites, including the female reproductive tract.FemTech Focus Podcast bioThe FemTech Focus Podcast with Dr. Brittany Barreto is a meaningfully provocative conversational series that brings FemTech experts - including doctors, scientists, inventors, and founders - on air to talk about the innovative technology, services, and products (collectively known as FemTech) that are improving women's health and wellness. Though many leaders in FemTech are women, this podcast is not specifically about female founders, nor is it geared toward a specifically female audience. The podcast gives our host, Dr. Brittany Barreto, and guests an engaging, friendly environment to learn about the past, present, and future of women's health and wellness.Time Stamps[03:00] Dr. Melissa Herbst-Kralovetz's background[05:18] Dr. Kate Rhodes' background[07:42] What is it like being a researcher of Women's Health?[11:33] An institute for Women's Health?[15:18] STI Statistics - globally and in women[17:22] Consequences of STI infection in women[23:33] Understanding the link between gonorrhea and the vaginal microbiome[28:54] Lubricant and the vaginal microbiome[32:38] The link between the vaginal microbiome and cancer[38:21] The gut microbiome and the vaginal microbiome[42:25] Is there “leaky vagina” like there is “_leaky gut_”?[44.27] Dr. Melissa's work with Native American communitiesResearch PapersPersonal and clinical vaginal lubricants: Impact on local vaginal microenvironment and implications for epithelial cell host response and barrier function.Clinical and personal lubricants impact growth of vaginal Lactobacillus species and colonization of vaginal epithelial cells: an in vitro study.ResourcesNative American Initiatives for training the next generation of students at University of ArizonaThe Summer Internship for Indigenous Peoples in GenomicsAmerican Indian Youth Wellness CampCall to Action!Make sure you subscribe to the podcast, and if you like the show please leave us a review!Episode ContributorsDr. Kate RhodesDr. Melissa Herbst-KralovetzHerbst-Kralovetz LabTwitter: @HerbstKralovetzLinkedIn: Melissa Herbst-KralovetzUniversity of Arizona Health SciencesLinkedIn: University of Arizona Health SciencesFacebook: @UAZHealthSciencesTwitter: @UAZHealthInstagram: @uazhealthsciencesYoutube: @UAHSCWebsite: https://healthsciences.arizona.edu/Dr Brittany BarretoLinkedIn: https://www.linkedin.com/in/brittanybarreto/Twitter: @DrBrittBInstagram: @drbrittanybarretoFemTech FocusLinkedIn: https://www.linkedin.com/company/femtechfocusTwitter: @FemTech_FocusInstagram: @femtechfocus
Videos: BOMBSHELL docs reveal Covid-19 COVER-UP goes straight to the top | Redacted with Clayton Morris – Whiselblower Sasha Latypova My Apology Letter Regarding My Friendship with Jordan Peterson (THE SAAD TRUTH_1365) Harari: “With this kind of surveillance [under the skin], (you can detect dissent). I mean, you watch the big President, the big leader, give a speech on television — the television could be monitoring you and knowing whether you're angry or not just by analyzing the cues.” MacDonald Brainwashed (Tom words of wisdom) – The Rap Eating almonds daily boosts exercise recovery molecule by 69% among ‘weekend warriors' Appalachian State University, January 6, 2023 For those who exercise regularly, eating almonds each day might be the ideal new year's resolution. A randomized controlled trial in Frontiers in Nutrition showed that female and male participants who ate 57g almonds daily for one month had more of the beneficial fat 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) in their blood immediately after a session of intense exercise than control participants. This molecule, a so-called oxylipin (oxidized fat) is synthetized from linoleic acid by brown fat tissue, and has a beneficial effect on metabolic health and energy regulation. Corresponding author Dr. David C Nieman, a professor and director of the Appalachian State University Human Performance Laboratory at the North Carolina Research Campus, said, “Here we show that volunteers who consumed 57g of almonds daily for one month before a single ‘weekend warrior' exercise bout had more beneficial 12,13-DiHOME in their blood immediately after exercising than control volunteers. They also reported feeling less fatigue and tension, better leg-back strength, and decreased muscle damage after exercise than control volunteers.” The clinical trial involved 38 men and 26 women between the ages of 30 and 65, who didn't engage in regular weight training. Approximately half were randomized to the almond diet group, and the other half to the control group, who daily ate a calorie-matched cereal bar. The researchers took blood and urine samples before and after the four-week period of dietary supplementation. Performance measures included a 30 second Wingate anaerobic test, a 50 meter shuttle run test, and vertical jump, bench press, and leg-back strength exercises. Additional blood and urine samples were taken immediately after this 90 minute session of ‘eccentric exercise' and daily for four days afterwards. As expected, the 90 minute exercise led to an increase in the volunteers' self-reported feeling of muscle damage and muscle soreness, as well as an increased POMS score, indicating self-reported decreased vigor and increased fatigue, anxiety, and depression. The exercise also resulted in transient elevated levels of pro-inflammatory cytokines such as IL-6, IL-8, IL-10, and MCP-1 in the blood, consistent with minor muscle damage. However, these changes in cytokines were equal in the almond and cereal bar groups. Importantly, immediately after exercise, the concentration of the beneficial 12,13-DiHOME was 69% higher in blood plasma of participants in the almond group than in participants in the control group. 12,13-DiHOME is known to increase the transport of fatty acid and its uptake by skeletal muscle, with the overall effect of stimulating metabolic recovery after exercise. The reverse pattern was found for another oxylipin, the mildly toxic 9,10-Dihydroxy-12-octadecenoic acid (9,10-diHOME), which was 40% higher immediately after exercise in the blood of the control group than in the almond group. Unlike 12,13-DiHOME, 9,10-diHOME has been shown have negative effects on overall health and the body's recovery to exercise. Nieman and colleagues concluded that daily consumption of almonds leads to a change in metabolism, downregulating inflammation and oxidative stress from exercise and enabling the body to recover faster. “We conclude that almonds provide a unique and complex nutrient and polyphenol mixture that may support metabolic recovery from stressful levels of exercise. Almonds have high amounts of protein, healthy types of fats, vitamin E, minerals, and fiber. And the brown skin of almonds contains polyphenols that end up in the large intestine and help control inflammation and oxidative stress,” said Nieman. Omega-3 supplements can prevent childhood asthma Copenhagen University Hospital, December 29, 2022 Taking certain omega-3 fatty acid supplements during pregnancy can reduce the risk of childhood asthma by almost one third, according to a new study from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and the University of Waterloo. The study, published in the New England Journal of Medicine, found that women who were prescribed 2.4 grams of long-chain omega-3 supplements during the third trimester of pregnancy reduced their children's risk of asthma by 31 per cent. Long-chain omega-3 fatty acids, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in cold water fish, and key to regulating human immune response. “We've long suspected there was a link between the anti-inflammatory properties of long-chain omega-3 fats, the low intakes of omega-3 in Western diets and the rising rates of childhood asthma,” said Professor Hans Bisgaard of COPSAC at the Copenhagen University Hospital. “This study proves that they are definitively and significantly related.” The testing also revealed that women with low blood levels of EPA and DHA at the beginning of the study benefitted the most from the supplements. For these women, it reduced their children's relative risk of developing asthma by 54 per cent. “The proportion of women with low EPA and DHA in their blood is even higher in Canada and the United States as compared with Denmark. So we would expect an even greater reduction in risk among North American populations,” said Professor Stark. “Identifying these women and providing them with supplements should be considered a front-line defense to reduce and prevent childhood asthma.” “Asthma and wheezing disorders have more than doubled in Western countries in recent decades,” said Professor Bisgaard. “We now have a preventative measure to help bring those numbers down.” Currently, one out of five young children suffer from asthma or a related disorder before school age. Study shows gardening may help reduce cancer risk, boost mental health University of Colorado at Boulder, January 6, 2023 The first-ever, randomized, controlled trial of community gardening found that those who started gardening ate more fiber and got more physical activity—two known ways to reduce risk of cancer and chronic diseases. They also saw their levels of stress and anxiety significantly decrease. The findings were published in The Lancet Planetary Health. “These findings provide concrete evidence that community gardening could play an important role in preventing cancer, chronic diseases and mental health disorders,” said senior author Jill Litt, a professor in the Department of Environmental Studies at CU Boulder. “No matter where you go, people say there's just something about gardening that makes them feel better,” said Litt, who is also a researcher with the Barcelona Institute for Global Health. Some small observational studies have found that people who garden tend to eat more fruits and vegetables and have a healthier weight. But it has been unclear whether healthier people just tend to garden, or gardening influences health. Only three studies have applied the gold standard of scientific research, the randomized controlled trial, to the pastime. None have looked specifically at community gardening. To fill the gap, Litt recruited 291 non-gardening adults, average age of 41, from the Denver area. More than a third were Hispanic and more than half came from low-income households. The gardening group received a free community garden plot, some seeds and seedlings, and an introductory gardening course through the nonprofit Denver Urban Gardens program and a study partner. By fall, those in the gardening group were eating, on average, 1.4 grams more fiber per day than the control group—an increase of about 7%. The authors note that fiber exerts a profound effect on inflammatory and immune responses, influencing everything from how we metabolize food to how healthy our gut microbiome is to how susceptible we are to diabetes and certain cancers. While doctors recommend about 25 to 38 grams of fiber per day, the average adult consumes less than 16 grams. “An increase of one gram of fiber can have large, positive effects on health,” said co-author James Hebert, director of University of South Carolina's cancer prevention and control program. The gardening group also increased their physical activity levels by about 42 minutes per week. Public health agencies recommend at least 150 minutes of physical activity per week, a recommendation only a quarter of the U.S. population meets. With just two to three visits to the community garden weekly, participants met 28% of that requirement. Study participants also saw their stress and anxiety levels decrease, with those who came into the study most stressed and anxious seeing the greatest reduction in mental health issues. The study also confirmed that even novice gardeners can reap measurable health benefits of the pastime in their first season. As they have more experience and enjoy greater yields, Litt suspects such benefits will increase. Researchers shed light on how exercise preserves physical fitness during aging Joslin Diabetes Center, December 6, 2023 Proven to protect against a wide array of diseases, exercise may be the most powerful anti-aging intervention known to science. However, while physical activity can improve health during aging, its beneficial effects inevitably decline. The cellular mechanisms underlying the relationship among exercise, fitness and aging remain poorly understood. In a paper published in the Proceedings of the National Academy of Sciences, researchers at Joslin Diabetes Center investigated the role of one cellular mechanism in improving physical fitness by exercise training and identified one anti-aging intervention that delayed the declines that occur with aging in the model organism. Together, the scientists' findings open the door to new strategies for promoting muscle function during aging. “Our data identify an essential mediator of exercise responsiveness and an entry point for interventions to maintain muscle function during aging.” That essential mediator is the cycle of fragmentation and repair of the mitochondria, the specialized structures, or organelles, inside every cell responsible for producing energy. Mitochondrial function is critical to health, and disruption of mitochondrial dynamics the cycle of repairing dysfunctional mitochondria and restoring the connectivity among the energy-producing organelles — has been linked to the development and progression of chronic, age-related diseases, such as heart disease and type 2 diabetes. “As we perceive that our muscles undergo a pattern of fatigue and restoration after an exercise session, they are undergoing this mitochondrial dynamic cycle,” said Blackwell, who is also acting section head of Immunobiology at Joslin. “In this process, muscles manage the aftermath of the metabolic demand of exercise and restore their functional capability.” “We determined that a single exercise session induces a cycle of fatigue and physical fitness recovery that is paralleled by a cycle of the mitochondrial network rebuilding,” said first author Juliane Cruz Campos, a postdoctoral fellow at Joslin Diabetes Center. “Aging dampened the extent to which this occurred and induced a parallel decline in physical fitness. That suggested that mitochondrial dynamics might be important for maintaining physical fitness and possibly for physical fitness to be enhanced by a bout of exercise.” Finally, the researchers tested known, lifespan-extending interventions for their ability to improve exercise capacity during aging. Worms with increased AMPK — a molecule that is a key regulator of energy during exercise which also promotes remodeling of mitochondrial morphology and metabolism — exhibited improved physical fitness. They also demonstrated maintenance of, but not enhancement of, exercise performance during aging. Worms engineered to lack AMPK exhibited reduced physical fitness during aging as well as impairment of the recovery cycle. They also did not receive the age-delaying benefits of exercise over the course of the lifespan. Nighttime electronic device use lowers melatonin levels Brigham and Women's Hospital, December 24 2022. The Proceedings of the National Academy of Science published the findings researchers at Boston's Brigham and Women's Hospital of a suppressive effect for evening use of light-emitting electronic devices on sleep and melatonin secretion. “Electronic devices emit light that is short-wavelength-enriched light, which has a higher concentration of blue light — with a peak around 450 nm — than natural light,” explained lead author Anne-Marie Chang. “This is different from natural light in composition, having a greater impact on sleep and circadian rhythms.” Twelve healthy adults were randomized to read a light-emitting eBook or a printed book in dim room light approximately four hours before bedtime for five evenings. At the end of the five day period, participants switched their assignments. Blood samples collected during portions of the study were analyzed for melatonin levels. Sleep latency, time and efficiency were assessed via polysomnography. eBook reading was associated with more time needed to fall asleep and less rapid eye movement sleep in comparison with reading a printed book. Evening melatonin levels were suppressed by an average of 55.12% in eBook readers, while those who read printed books had no suppression. Compared to printed book reading, the onset of melatonin release in response to dim light occurred 1 ½ hours later the day following reading of an eBook. “Our most surprising finding was that individuals using the e-reader would be more tired and take longer to become alert the next morning,” Dr Chang reported. “This has real consequences for daytime functioning, and these effects might be worse in the real world as opposed to the controlled environment we used.” “We live in a sleep-restricted society, in general,” she added. “It is important to further study the effects of using light-emitting devices, especially before bed, as they may have longer term health consequences than we previously considered.” Iron deficiency anemia associated with hearing loss Penn State University, December 29, 2022 In a study published online by JAMA Otolaryngology-Head & Neck Surgery, Kathleen M. Schieffer, B.S., of the Pennsylvania State University College of Medicine, Hershey, Pa., and colleagues examined the association between sensorineural hearing loss and conductive hearing loss and iron deficiency anemia in adults ages 21 to 90 years in the United States. Approximately 15 percent of adults report difficulty with hearing. Because iron deficiency anemia (IDA) is a common and easily correctable condition, further understanding of the association between IDA and all types of hearing loss may help to open new possibilities for early identification and appropriate treatment. For this study, using data obtained from deidentified electronic medical records from the Penn State Milton S. Hershey Medical Center in Hershey, Pa., iron deficiency anemia was determined by low hemoglobin and ferritin levels for age and sex in 305,339 adults ages 21 to 90 years; associations between hearing loss and IDA were evaluated. Of the patients in the study population, 43 percent were men; average age was 50 years. There was a 1.6 percent prevalence of combined hearing loss (defined as any combination of conductive hearing loss [hearing loss due to problems with the bones of the middle ear], sensorineural hearing loss, deafness, and unspecified hearing loss) and 0.7 percent prevalence of IDA. Both sensorineural hearing loss (SNHL; when there is damage to the cochlea or to the nerve pathways from the inner ear to the brain) (present in 1.1 percent of individuals with IDA) and combined hearing loss (present in 3.4 percent) were significantly associated with IDA. Analysis confirmed increased odds of SNHL and combined hearing loss among adults with IDA. “An association exists between IDA in adults and hearing loss. The next steps are to better understand this correlation and whether promptly diagnosing and treating IDA may positively affect the overall health status of adults with hearing loss,” the authors write.
Welcome back to A Season of Reflections - Part 6. This week we unpack the theme of self-care across fascinating conversations from our previous guests, including Professor of Biochemistry and Immunobiology at Trinity College Dublin Luke O'Neill, author and Mental Health Activist Daragh Fleming, High Performance Leadership Expert James Laughlin, Human Performance Consultant & Lecturer at Auburn University Dr Ford Dyke, Yoga Teacher in German Premier League (Bundesliga) Brad Franco, and finally Comic Relief Programme Director and former CEO of Special Olympics Michelle Carney. Timestamps for this monster episode are: (2:00) Prof Luke O Neill - Professor of Biochemistry and Immunobiology at Trinity College Dublin Self care by taking mini-breaks,and doing nothing...with purpose (03:34) Daragh Fleming - Author and Mental Health Activist Using journaling as a method of self care Making sense and organising unhelpful thoughts Addressing emotion through action Be sound and drink water (12:00) James Laughlin - High Performance Leadership Expert Creating an awareness around the decisions we make D.A.P.P.E.R. as a technique to overcome adversity (21:50) Dr Ford Dyke - Human Performance Consultant & Lecturer at Auburn University Only needing 60 seconds of time Creating a quiet space in a busy mind Creating a practice that sticks A winning morning routine for high performers (30:59) Brad Franco - Yoga Teacher in German Premier League (Bundesliga) Self care through digital detoxing Creating a flow state in others around you Meditate in solitude, but work together to achieve Taking a slow growth path to success and being present along the way (39:05) Michelle Carney - Comic Relief Programme Director and former CEO of Special Olympics Being resilient through peaks and troughs of life Creating equal opportunities for us all Showing positivity and kindness to help others Giving back or supporting others for our own benefit Our Three Takeaways: Consider starting to journal Find a process that works for you You don't need much time Thanks for tuning in! For information on previous guests and shows please visit www.SleepEatPerformRepeat.com. Previous guests include Cal Newport, Dr Michael Gervais, Joy Neville, Rich Froning, BJ Fogg, Sonia O'Sullivan, Rich Diviney, Keith Earls, Caelan Doris, Chanelle McCoy, PJ Nestler, Jack Butcher, Shane O'Sullivan, Louise Galvin, Chris Burkard, Brian Keane, Steve Magness, Lindsay Peat, Owen Eastwood, Steven Kotler, Daniel Davey, Ray Goggins, Shane O'Donnell, Jonny Cooper, Capt. Emily Bassett, George Kruis, Brett Bartholomew, Aoife McDermott, Lisa Jacob and many more.
Career Development Panel Series 3 Drawing on faculty interest, the Center for Faculty Development has organized a series of four webinars on specific aspects of academic career development, whether to build toward promotion consideration or to enrich professional knowledge and experience. Learn more about where to find and how to join initiatives or committees of interest, the dimensions of major administrative roles, how and when to get involved on an editorial board, and, ultimately, when it makes sense to say yes to a new responsibility—or decline the opportunity. Learning Objectives: Upon completion of this activity, participants will be able to: Discuss ways to be involved in NIH study sections/reviewing grant applications Illustrate best approaches to conveying an interest in getting involved as an editorial board member or in an NIH study section Assess best approach to publish an impactful editorial/perspectives/opinion articles Panelists: Stephen B. Calderwood, MD, Chief Emeritus of Infectious Diseases at Massachusetts General Hospital and Morton N. Swartz MD Academy Professor of Medicine (Microbiology and Immunobiology) at HMS Darshan Mehta, MD, MPH, Education Director, Osher Center for Integrative Medicine and Director, CFD's Office for Well-Being Click for webinar
Joining us for Episode 148 is the fascinating George Peppou, Founder and CEO of Vow Food, a cultivated meat company, founded and operated in Sydney. Vow is made up of a multidisciplinary team of scientists, technologists and designers, working together in the relentless pursuit of better food.By making meat with animal cells, and not the animals themselves, Vow is creating the world's most tantalising and unique culinary experiences without compromising on ethics or our planet along the way. Ian and George dive into George's career path so far, from studying Biochemistry and Immunobiology at Sydney University to Founder and CEO of Vow Food. Tune in to hear more on: The effects of the meat industry and food production on the Global greenhouse gas emissions How Vow as a product is produced and when it will first go to market The investment and growth stages of Vow Georges business and personal challenges Quick fire round: Book: Trillion Dollar Coach: The Leadership Handbook of Silicon Valley's Bill Campbell, By: Eric Schmidt, Jonathan Rosenberg, Alan Eagle Podcast: Lex Fridman and The Constant News Source: ABC/AFR for local news and The Atlantic App: Vimcal - Lightning-fast calendar for remote work Tech CEO: Elon Musk TV Show: Jerrfey Dahmer on Netflix Ted Talk: Woodwork and a mindfulness practice. George is a member of Summit Community at Innovation Bay. You can find more at VowFood.com, Twitter or Linkedin. Vow Food is hiring so be sure to keep an eye out on their careers page. See omnystudio.com/listener for privacy information.
Videos : ELDERLY SUICIDE – This is Agenda 21 – MUST SEE! 2022 Fauci, meet 2004 Fauci. FACT CHECK: it did not go well for 2022 Fauci. (1:23) Sam Bailey & Jessic Rose Part 1 (22:33) Gary Null Speaking Out at the NYS Assembly Hearing (25:00) Higher omega-3 levels linked to better sleep University of British Columbia, September 14 2022. Having higher blood concentrations of the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) was found to be associated with a reduction in excessive sleep in an analysis reported in 2022 in the American Journal of Clinical Nutrition. Sleep duration of over 9 hours per night has been correlated with an increased risk of cardiovascular disease and premature mortality from all causes. The analysis included 21,653 participants in 12 studies for whom information was available concerning sleep duration and/or difficulty falling asleep and blood levels of the omega-3 fatty acids EPA, DHA, ALA and, when available, DPA, and the omega-6 fatty acids AA and LA. When men and women whose fatty acid levels were among the lowest 20% of participants were compared to those whose levels were among the top 20%, individuals whose DHA intake was highest had a 22% lower risk of excessive sleep. Being among those who had the highest intake of EPA plus DHA and DPA was associated with a 24% lower risk. The authors noted that DHA's role in regulating melatonin production helps regulate sleep. Twice-daily nasal irrigation reduces COVID-related illness, death Medical College of Georgia at Augusta University, September 13, 2022 Starting twice daily flushing of the mucus-lined nasal cavity with a mild saline solution soon after testing positive for COVID-19 can significantly reduce hospitalization and death, investigators report. They say the technique that can be used at home by mixing a half teaspoon each of salt and baking soda in a cup of boiled or distilled water then putting it into a sinus rinse bottle is a safe, effective and inexpensive way to reduce the risk of severe illness and death from coronavirus infection that could have a vital public health impact. “By giving extra hydration to your sinuses, it makes them function better. “We found an 8.5-fold reduction in hospitalizations and no fatalities compared to our controls,” says senior author Dr. Richard Schwartz, chair of the MCG Department of Emergency Medicine. “Both of those are pretty significant endpoints.” The study appears to be the largest, prospective clinical trial of its kind and the older, high-risk population they studied—many of whom had preexisting conditions like obesity and hypertension—may benefit most from the easy, inexpensive practice, the investigators say. They found that less than 1.3% of the 79 study subjects age 55 and older who enrolled within 24-hours of testing positive for COVID-19 between Sept. 24 and Dec. 21, 2020, experienced hospitalization. No one died. Researchers know that the more virus that was present in your body, the worse the impact. “One of our thoughts was: If we can rinse out some of the virus within 24 hours of them testing positive, then maybe we can lower the severity of that whole trajectory,” she says, including reducing the likelihood the virus could get into the lungs, where it was doing permanent, often lethal damage to many. Baxter says the nasal irrigation with saline helps decrease the usual robust attachment. Saline appears to inhibit the virus' ability to essentially make two cuts in itself, called furin cleavage, so it can better fit into an ACE2 receptor once it spots one. Participants self-administered nasal irrigation using either povidone-iodine, that brown antiseptic that gets painted on your body before surgery, or sodium bicarbonate, or baking soda, which is often used as a cleanser, mixed with water that had the same salt concentration normally found in the body. Those who completed nasal irrigation twice daily reported quicker resolution of symptoms regardless of which of two common antiseptics they were adding to the saline water. Eating more spicy foods decreases your risk of early death by 14% Chinese Academy of Medical Sciences, September 7, 2022 According to an international team of researchers led by the Chinese Academy of Medical Sciences, eating spicy foods may be the key to longevity. They found that eating such foods on a regular basis can help prevent people from dying prematurely by 14 percent. While a variety of spicy foods are excellent, one in particular caught their attention. It was noted that consumption of fresh chili pepper, compared to other spicy foods, was most effective in providing people with a lower risk of dying from cancer, ischemic heart disease and diabetes. It's explained that fresh chili pepper's combination of powerful ingredients are responsible for such health-boosting benefits.(1) “Compared with non-fresh spicy foods such as dried chilli pepper, chilli sauce or chilli oil,” says Lu Qi, associate professor at Harvard School of Public Health, “fresh chilli pepper is richer in bioactive ingredients, including capsaicin, vitamin C, and other nutrients such as vitamin A, K, and B6 and potassium.”(1) To conduct the study, the experts from the Chinese Academy of Medical Sciences assessed nearly 490,000 participants. After a follow-up that averaged approximately seven years, 20,224 deaths were noted. Analysis of these people led to the finding that compared to those who ingested spicy foods less than once weekly, people who ate such foods one or two days per week had a 10 percent reduced risk of death. More impressive however, was the discovery that those who enjoyed spicy foods nearly every other day were at a 14 percent lowered risk of death compared to those who ate them less than once a week. In this large prospective study, we observed an inverse association between consumption of spicy foods and total mortality, after adjusting for potential confounders. Compared with those who ate spicy foods less than once a week, those who consumed spicy foods almost every day had a 14% lower risk of death. Inverse associations were also observed for deaths due to cancer, ischemic heart diseases, and respiratory diseases. The associations were consistent in men and women. Meditation holds the potential to help treat children suffering from traumas, difficult diagnoses or other stressors Wayne State University, September 13, 2022 Children actively meditating experience lower activity in parts of the brain involved in rumination, mind-wandering and depression, our team found in the first brain-imaging study of young people under 18 years old. Over-activity in this collection of brain regions, known as the default mode network, is thought to be involved in the generation of negative self-directed thoughts – such as “I am such a failure” – that are prominent in mental disorders like depression. In our study, we compared a simple form of distraction – counting backward from 10 – with two relatively simple forms of meditation: focused attention to the breath and mindful acceptance. Children in an MRI scanner had to use these techniques while watching distress-inducing video clips, such as a child receiving an injection. We found that meditation techniques were more effective than distraction at quelling activity in that brain network. This reinforces research from our lab and others showing that meditation techniques and martial arts-based meditation programs are effective for reducing pain and stress in children with cancer or other chronic illnesses – and in their siblings – as well as in schoolchildren during the COVID-19 pandemic. Researchers know a lot about what is happening in the brain and body in adults while they meditate, but comparable data for children has been lacking. Understanding what is happening in children's brains when they meditate is important because the developing brain is wired differently from the adult brain. Pace as important as 10,000 steps for health, finds new research University of Sydney and University of South Denmark, September 13, 2022 Two studies, published in JAMA Internal Medicine and JAMA Neurology, monitored 78,500 adults with wearable trackers—making these the largest studies to objectively track step count in relation to health outcomes. The researchers from the University of Sydney, Australia and University of Southern Denmark found lowered risk of dementia, heart disease, cancer and death are associated with achieving 10,000 steps a day. However, a faster stepping pace like a power walk showed benefits above and beyond the number of steps achieved. “The take-home message here is that for protective health benefits people could not only ideally aim for 10,000 steps a day but also aim to walk faster,” said co-lead author Dr. Matthew Ahmadi, Research Fellow at the University of Sydney's Charles Perkins Centre and Faculty of Medicine and Health. Key points: Every 2,000 steps lowered risk of premature death incrementally by 8 to 11 percent, up to approximately 10,000 steps a day. Similar associations were seen for cardiovascular disease and cancer incidence. A higher number of steps per day was associated with a lower risk of all-cause dementia 9,800 steps was the optimal dose linked to lower risk of dementia by 50 percent, however risk was reduced by 25 percent at as low as 3,800 steps a day Feed a virus, starve a bacterial infection? Yale University, September 8, 2022 A new study puts some old folk wisdom to “feed a cold and starve a fever” to the test. In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral. Mice with bacterial infections that were fed died, while those with viral infections who were fed lived. “We were surprised at how profound the effects of feeding were, both positive and negative,” says senior author Ruslan Medzhitov, David W. Wallace Professor of Immunobiology and a Howard Hughes Medical Institute investigator at Yale School of Medicine. In the first series of experiments, the investigators infected mice with the bacterium Listeria monocytogenes, which commonly causes food poisoning. The mice stopped eating, and they eventually recovered. But when the mice were force fed, they died. The researchers then broke the food down by component and found fatal reactions when the mice were given glucose, but not when they were fed proteins or fats. When the researchers did similar studies in mice with viral infections, they found the opposite effect. Mice infected with the flu virus A/WSN/33 survived when they were force fed glucose, but died when they were denied food or given 2-DG.
Antiviral drugs and other therapeutics New drugs and vaccines in the pipeline Are universal vaccines a pipe dream? Why vaccines are only part of the answer and will never control the pandemic? Lesson learned on how to stop the next pandemic Host: Dr David Lim | Total time: 33 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Every second Tuesday | 7:00pm-9:00pm AEST Click here to register now!See omnystudio.com/listener for privacy information.
That's Cool News | A weekly breakdown of positive Science & Tech news.
NEWS: Sugar-studded protein is key to an Alzheimer's cure | The Brighter Side (01:38) In a bit of “reverse engineering” research using brain tissues from five people who died with Alzheimer's disease, Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer's disease. This could indicate the molecule, known as a glycan, to be used as an early diagnostic test. And opens a way to perhaps prevention of the disease Cleaning up the disease-causing forms of amyloid and tau is the job of the brain's immune cells, called microglia. Earlier studies found that when cleanup is impaired, Alzheimer's disease is more likely to occur. Thought to be caused by an overabundance of a receptor on the microglia cells, called CD33. Past studies by the researchers showed that for CD33, these “connector” molecules are special sugars.These molecules are ferried around the cell by specialized proteins that help them find their appropriate receptors. The protein-glycan combination is called a glycoprotein. The researchers, to find out more about the glycoproteins, obtained brain tissue from five people who died of Alzheimer's disease and from five people.Among the many thousands of glycoproteins they gathered from the brain tissues, only one connected to CD33. What was this mysterious glycoprotein?The researchers determined the protein component's identity by taking its “fingerprint” using mass spectroscopy, which identifies protein building blocks. Then they compared the molecular makeup of the protein with a database of known protein structures. The research team was able to conclude the protein portion of the glycoprotein was receptor tyrosine phosphatase (RPTP) zeta. Further experiments showed that the brain tissue of the five people who died with Alzheimer's disease had more than twice as much RPTP zeta S3L as the donors who did not have the disease. Implying that this glycoprotein may be connecting with more CD33 receptors than a healthy brain, limiting the brain's ability to clean up harmful proteins. Gonzalez-Gil Alvarenga, Ph.D., first author on the study stated:“Identifying this unique glycoprotein provides a step toward finding new drug targets and potentially early diagnostics for Alzheimer's disease.” A Surprising Link Between Immune System and Hair Growth | Neuroscience News (07:36) Salk scientists have uncovered an unexpected molecular target of a common treatment for alopecia, a condition in which a person's immune system attacks their own hair follicles, causing hair loss. Corresponding author of the study, Ye Zheng, associate professor in Salk's NOMIS Center for Immunobiology and Microbial Pathogenesis, stated:“For the longest time, regulatory T cells have been studied for how they decrease excessive immune reactions in autoimmune diseases … Now we've identified the upstream hormonal signal and downstream growth factor that actually promote hair growth and regeneration completely separate from suppressing immune response.” Initially the researchers were interested in researching the roles of regulatory T cells and glucocorticoid hormones in autoimmune diseases.They did not function together to play a significant role in any of these conditions. Thought they'd have more luck looking at environments where regulatory T cells expressed particularly high levels of glucocorticoid receptors The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The scientists induced hair loss in normal mice and mice lacking glucocorticoid receptors in their regulatory T cells.After two weeks, the researchers saw the normal mice grew their hair back, while the ones lacking the receptors struggled to grow it back The findings suggested that some sort of communication must be occurring between regulatory T cells and hair follicle stem cells to allow for hair regeneration.They continued to investigate how the regulatory T cells and glucocorticoid receptors behaved in skin tissue samples. They found that glucocorticoids instruct the regulatory T cells to activate hair follicle stem cells, which leads to hair growth. Depends on a mechanism whereby glucocorticoid receptors induce production of the protein TGF-beta3, all within the regulatory T cells. TGF-beta3 then activates the hair follicle stem cells to differentiate into new hair follicles, promoting hair growth. This study revealed that regulatory T cells and glucocorticoid hormones are not just immunosuppressants but also have a regenerative function. Next, the scientists will look at other injury models and isolate regulatory T cells from injured tissues to monitor increased levels of TGF-beta3 and other growth factors. Engineers devise clever system for EVs to share charge—while driving | Anthropocene (13:34) The charging station expansion isn't keeping up with the growing number of EVs on the road.The number of EVs on the road per public charging point globally rose to 9.2 at the end of last year, from 7.4 at the end of 2020, according to a study by BloombergNEF analyst Ryan Fisher on the state of public charging infrastructure. In a new study, engineers propose a way around this conundrum: EVs that share charge with each other while driving. In their vision, cars with low batteries could buy some charge from others with extra to spare, all without stopping. Could be orchestrated via a cloud-based control system Electrical and computer engineer Prabuddha Chakraborty the University of Florida and his colleagues propose a two-battery system for EVs.A large, slow-charging lithium-ion battery would drive the car, A smaller, fast-charging battery would be used for on-the-go charging. Once powered up, the small battery would transfer its charge to the car's main battery. “Just like in your computer you have fast cache memory—but it's expensive—so you have other type of high-capacity memories that are slower,” said Tamzidul Hoque, a professor of electrical engineering and computer science at the University of Kansas The cloud-based system idea:Monitor charge levels of electric cars. If a car's power is starting to run low, the network would alert it to other cars nearby with enough charge to sell. Once two cars are matched with owner consent, cables would connect them for charging and they would be locked at the same speed until the power transfer is complete. Yet even in a well-planned, dynamic peer charging network, the researchers found in simulations that the total charge of the network will slowly deplete.To try to get around this idea, they propose the concept of mobile charging stations: large battery-loaded trucks that would recharge multiple vehicles at once. Like military jets being refueled in-flight by tanker aircraft. Using popular traffic modeling software they were able to simulate their idea somewhat.They found that it would eliminate range anxiety and re-charging wait time, and reduce EV cost by eliminating the need to have big batteries. Scientists Use Vegetable Oil Byproduct to Remove Heavy Metals From Contaminated Water | EcoWatch (20:27) Scientists from Nanyang Technological University, Singapore, collaborating with ETH Zurich, Switzerland (ETHZ), have discovered a way to turn byproduct from vegetable oil production into a membrane that filters out heavy metals from water. Ali Miserez, study author and professor at Nanyang Technological University, stated:“Water pollution remains a major global issue in many parts of the world…Heavy metals represent a large group of water pollutants that can accumulate in the human body, causing cancer and mutagenic diseases. Current technologies to remove them are energy-intensive, requiring power to operate, or are highly selective in what they filter.” The researchers noticed that proteins in peanut and sunflower oil waste byproducts, called oilseed meals, were useful in attracting heavy metal ions.Turned the oilseed meals' proteins into nano-sized protein amyloid fibrils, which strongly attract heavy metal ions. Combined these amyloid fibrils with activated carbon and tested the filters on three types of metal: platinum, chromium and lead. The membranes were 99.89% effective at filtering out all of the heavy metals from water, with the best results for platinum and lead. The membrane made from waste byproduct proteins is a low-cost option that requires little energy for decontamination, and the researchers say this innovation could work all over the world for water purification. “Recovering precious platinum, which costs US$33,000/kg, only requires 32 kg of protein, while recovering gold, which is worth almost US$60,000/kg, only requires 16 kg of protein. Considering that these proteins are obtained from industrial waste that is worth less than US$1/kg, there are large cost benefits,” Miserez explained. Because of the simple technology, this filtration membrane is readily scalable, according to the researchers. Tesla launches new virtual power plant that pays Powerwall owners to help end brownouts | Electrek (25:30) Tesla has launched a new virtual power plant in partnership with PG&E in California that will pay Powerwalls owners to help stabilize the electric grid and end brownouts in California. What is a virtual power plant?Consists of distributed energy storage systems, like Tesla Powerwalls, used in concert to provide grid services and avoid the use of polluting and expensive peaker power plants. Tesla has partnered with PG&E to launch a new version of its virtual power plant that will actually compensate people participating:The company's statement: “Become a part of the largest distributed battery in the world and help keep California's energy clean and reliable. Opt-in to the Tesla Virtual Power Plant (VPP) with PG&E and your Powerwall will be dispatched when the grid needs emergency support. Through the Emergency Load Reduction Program (ELRP) pilot, you will receive $2 for every additional kWh your Powerwall delivers during an event. Adjust your Backup Reserve to set your contribution, while maintaining backup energy for outages.” Depending on the events and the number of Powerwalls homeowners have, they could earn anywhere from $10 to $60 per event or even more for bigger systems. The extra capacity your Powerwall provides could help avoid or reduce blackouts in a severe emergency. This way, Powerwall can keep the lights on for both you and your community. Tesla said that it has about 50,000 Powerwalls that could be eligible for this VPP, which add up to a significant 500 MWh of energy capacity than can be distributed in any event.
We should begin transitioning our patients to Novavax and protein-based vaccines and away from mRNA Monkeypox should be taken seriously… especially for high-risk patients New viruses are emerging so we need to reinforce the importance of ongoing personal hygiene The previous government has significantly undermined our capacity to deal with serious public health issues Host: Dr David Lim | Total time: 38 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our fortnightly FREE WEBCASTS Every second Tuesday | 7:00pm-9:00pm AEST Click here to register for the next one See omnystudio.com/listener for privacy information.
GUEST OVERVIEW: Rhys Collyer is the youngest United Australia party candidate for Bennelong at just 24 years old. Rhys graduated from high school with academic honours, then studied at University of Sydney where he obtained a Bachelor of Medical Science, where he completed majors in Pharmacology, Immunobiology, Microbiology, Virology and Physiology.
AMA CXO Todd Unger discusses the latest research on long COVID with Akiko Iwasaki, PhD, the Sterling Professor of Immunobiology at Yale University and a principal investigator at the Howard Hughes Medical Institute.
This hour, an assortment of topics. First up: why future COVID-19 boosters may be administered through the nose. Next, we learn all about masks. Finally: we get up to speed on the Winter Olympics. GUESTS: Dr. Akiko Iwasaki - The Waldemar Von Zedtwitz Professor of Immunobiology at Yale University, and an Investigator of the Howard Hughes Medical Institute. Dr. Iwasaki is on a team studying nasal COVID-19 boosters. Aaron Collins - A mechanical engineer with a background in aerosol science, who tests and evaluates masks on his YouTube channel, and publishes all the data in a Google doc. Ben Waterworth - An Australian journalist, radio host, and host of many podcasts, including “Off The Podium,” a podcast about the Olympics. Support the show: http://www.wnpr.org/donateSee omnystudio.com/listener for privacy information.
COVID vaccine boosters & Novavax Rapid antigen testing Debunking recent COVID myths Why we should be optimistic Host: Dr David Lim | Total time: 37 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming free webcast Tuesday 1 February 2022 | 7:00pm-9:00pm AEDT Click here to register now See omnystudio.com/listener for privacy information.
Dr. Sucharit Bhakdi is an American born physician trained in Germany and has been in the medical field now for five decades. He received his medical degree from the University of Bonn and did his post-doctoral work at the prestigious Max Planck Institute of Immunobiology and Epigenetics before becoming an associate professor at the Institute of Medical Microbiology at Gressen University. Later he was appointed as the chair of Medical Microbiology at the University of Mainz. Dr. Bhakdi has published over 300 articles in the fields of immunology, bacteriology and virology and has received numerous awards including the Order of Merit of Rhineland. His book, co-written with his biologist wife Dr. Karina Reiss -- "Corona False Alarm?: Facts and Figures," --- which has been written for the layperson to understand the pandemic clearly -- became a national best seller in Germany and later rapidly receiving international attention.
Latest data on immune escape, infectivity and pathogenicity Implications for the Australian and world public health effort Is Omicron a sign that the pandemic is burning out? Host: Dr David Lim | Total time: X mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming free webcast Tuesday 1 February 2022 | 7:00pm-9:00pm AEDT Click here to register now See omnystudio.com/listener for privacy information.
At this stage, Omicron does not appear to be causing severe disease so right now there is little cause for alarm But we need more time to understand it, especially its impact on the most vulnerable groups The key information will become available within 2-3 weeks This development highlights vaccine equity as a very important issue Per capita, Australia has donated more covid vaccines than any other country except the USA Host: Dr David Lim | Total time: 33 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Tuesday 27 April 2021 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
This is the Novavax update we've been waiting for All of the frequently asked questions Novavax promises to be a very positive addition to our national COVID strategy Host: Dr David Lim | Total time: 39 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our fortnightly FREE WEBCASTS Every second Tuesday | 7:00pm-9:00pm AEST Click here to register for the next one See omnystudio.com/listener for privacy information.
Dr. Sucharit Bhakdi is an American born physician trained in Germany and has been in the medical field now for five decades. He received his medical degree from the University of Bonn and did his post-doctoral work at the prestigious Max Planck Institute of Immunobiology and Epigenetics before becoming an associate professor at the Institute of Medical Microbiology at Gressen University. Later he was appointed as the chair of Medical Microbiology at the University of Mainz. Dr. Bhakdi has published over 300 articles in the fields of immunology, bacteriology and virology and has received numerous awards including the Order of Merit of Rhineland. His book, co-written with his biologist wife Dr. Karina Reiss -- "Corona False Alarm?: Facts and Figures," --- which has been written for the layperson to understand the pandemic clearly -- became a national best seller in Germany and later rapidly receiving international attention.
Dr Gary Grohmann raises important issues and questions surrounding the imminent release of home rapid antigen test kits in Australia. It is not as clear and simple as it may sound. Host: Dr David Lim | Total time: 41 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our fortnightly FREE WEBCASTS Every second Tuesday | 7:00pm-9:00pm AEDT Click here to register for the next one See omnystudio.com/listener for privacy information.
In this special extended interview, Dr. Bhakdi and the Voices for Freedom team discuss the current issues surrounding the CV vax rollout here in NZ. We dive into some entertaining detail (dinosaurs make an appearance!) regarding the recent important study showing the presence of the spike protein and S1 subunit in the plasma of the recently jabbed, including how and why it is an issue & why NZ's experts SHOULD be paying attention. Enjoy the show! Dr. Bhakdi was born in Washington, DC, and educated at schools in Switzerland, Egypt, and Thailand. He studied medicine at the University of Bonn in Germany, where he received his MD in 1970. He was a post-doctoral researcher at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and at The Protein Laboratory in Copenhagen.
The divide between the Covid vaccine haves and have-nots has been described as “criminal”, with only 20% of people in low and middle income countries having had one dose, compared with 80% in higher income countries. Countries with high vaccination rates have been called on to give up their place in the vaccine queue. The dual-track global vaccination programme has led to real anger, made worse by announcements of booster programmes in richer countries (despite the World Health Organisation calling for such plans to be put on hold). Claudia Hammond and her panel of global experts discuss the scale of vaccine inequity and consider whether evidence of waning vaccine immunity justifies the rollout of booster jabs, or if the soundest scientific case dictates everybody in the world should be vaccinated first. Claudia's guests include Dr Yodi Alakija, co-chair of the African Union's Delivery Alliance for Covid-19 in Abuja, Nigeria, Dr Maria Van Kerkhove, the World Health Organisation's Technical Lead for Covid in Geneva, Switzerland and two world leading immunologists, Dr Peter Openshaw, Professor of Experimental Medicine at Imperial College, London, UK and Dr Akiko Iwasaki, Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University in the US. Produced by: Fiona Hill, Paula McGrath and Maria Simons Studio Engineers: Jackie Marjoram
In this week's SportSquire Wellness Corner, Brad speaks to the large body of research that has been done in the exercise immunology field and the great promise the field has to uncover with future research focal points. He highlights Dr. Richard Simpson PHD's article Titled: Exercise, Immunity, and the COVID-19 Pandemic. Dr. Simpson's research interests are concerned with the effects of aging, stress and exercise on the immune system. He is an associate professor in the Departments of Nutritional Sciences, Pediatrics and Immunobiology at the University of Arizona. You can read it in it's entirety here. https://www.acsm.org/blog-detail/acsm-blog/2020/03/30/exercise-immunity-covid-19-pandemic. It is a good read that lays out in layman's terms the impact that exercise has on our immune function. Simpson writes in his blog, "Having higher age and sex-adjusted scores for cardiorespiratory fitness and performing regular exercise of moderate- to vigorous-intensity exercise that fall within ACSM (American College of Sports Medicine) guidelines has been shown to improve immune responses to vaccination, lower chronic low-grade inflammation, and improve various immune markers in several disease states including cancer, HIV, cardiovascular disease, diabetes, cognitive impairment and obesity. The ongoing COVID-19 pandemic has raised a lot of questions regarding how exercise can protect us from infection by boosting immunity.”
One dose of COVID vaccine can reduce secondary outcomes of severe disease and hospitalisations by about 60% Vaccinated individuals can still become infected and transmit the virus and may cause severe disease in those whom they have spread it to Novavax may become the preferred vaccine for boosters, which may be required in 12 months Even after full vaccination, personal safety with masks, hand washing, social distancing and avoiding mass gatherings remain the cornerstone of prevention of COVID Host: Dr David Lim | Total time: 44 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our fortnightly FREE WEBCASTS Every second Tuesday | 7:00pm-9:00pm AEDT Click here to register for the next one See omnystudio.com/listener for privacy information.
On this episode of Fault Lines, hosts Jamarl Thomas and Shane Stranahan are joined by producer Austin Pelli to talk about the environment in Geneva around the meeting between Putin and Biden, the PBS documentary painting a terrorist as ‘misunderstood', the true science behind coronaviruses and Covid-19, and the foreign policy of President Biden regarding China and Russia.Guests:Maram Susli - Syrian patriot and Sunni Muslim from Damascus | PBS Whitewashing Al Qaeda Militant, Future of US Involvement in SyriaDr Craig Wilen - Assistant Professor of Laboratory Medicine and of Immunobiology at Yale University | The Science Behind COVID-19Mark Sleboda - International Relations and Security Analyst | The Biden Administration on Russia and ChinaIn the first Fault Lines was joined by Jamarl Thomas for his on-the-ground reporting in Europe, as he heads towards Geneva for the summit meeting between Putin and BidenIn the second hour Fault Lines was joined by Maram Susli to discuss PBS's documentary series giving a facelift to a terrorist, what the United States withdrawal from Afghanistan signals for its involvement in Syria, and where this week's meetings will leave the ongoing conflict.In the third hour we were joined by Dr. Craig Wilen for a discussion on Covid19 and many of the misconceptions around this and like viruses. Mark Sleboda also joined to highlight some of the major similarities and differences in Biden's foreign policies, especially regarding China and Russia.
Dr. Loving's degrees: B.S. Iowa State University, Zoology (2001), Ph.D. Iowa State University, Immunobiology (2006), Postdoc - Food and Drug Administration, Bethesda, MD (2006-2008). Research interests: My research objectives include identifying critical interactions between commensal intestinal microbiota and the developing immune system that contribute to a balanced and healthy pig. This understanding will lead to the development of intervention strategies to limit in-feed antibiotic use and colonization with foodborne pathogens. My laboratory is interested in better understanding the immune cells and molecules that interact with the microbiota throughout the intestinal tract, with a particular focus on the ileum and cecum. These locations harbor very distinct immune cell populations and organisms, and are unique niches for identifying mechanisms in which these two co-evolved systems interact to maintain a balanced and healthy intestinal ecosystem. We are also interested in immunometabolism as a biomarker of animal health and have been exploring change in lymphocyte metabolism under different feed and health conditions. We use various immunological assays and tools to assess the phenotype of immune cell populations and function (cytokine expression, proliferation, metabolism), as well as different husbandry conditions (dietary components, immunomodulators, lactogenic immunity) to monitor intestinal physiological and immunological responses. My research has also focused on evaluating the immune response associated with protective immunity against influenza virus in pigs, with an emphasis on identifying correlates of protection associated with live-attenuated influenza virus vaccination. In addition, I've worked on evaluating immune responses following administration of various alternatives to antibiotics to limit disease in swine, including different vaccine platforms and various immunomodulators. *This podcast is operated by Swine Impact, a Swine it Company.
In this episode, I converse with Zuri Sullivan, an HHMI Hanna H. Gray Postdoctoral Fellow in Prof. Catherine Dulac's lab at Harvard University. Zuri earned an AB in Molecular and Cellular Biology from Harvard and then pursued her interests in global health and host-microbe interactions as a Fulbright Scholar at the KwaZulu-Natal Research Institute for Tuberculosis and HIV in Durban, South Africa. Wanting to delve deeper into the biology of host defense, Zuri earned a PhD in Immunobiology as an NSF Graduate Research Fellow at Yale University under the auspice of Prof. Ruslan Medzhitov. Zuri is fascinated by interactions between the immune and nervous systems, passionate about sharing science with the public, and dedicated to increasing the representation of women and people of color in STEM. We indulge in a fantastic conversation on her stellar journey in science; brilliant research at the intersection of immunology and neuroscience; battling the ubiquitous imposter syndrome; wonderful mentors who've guided and inspired her; rooting out inequities in science and society; her passionate outreach and communication to inspire future generations to pursue science; her eclectic reading list; and many more things!!
In this episode: Instead of efficacy, look at the secondary endpoints as vaccine data is being released Whilst the evidence for giving the AstraZeneca Oxford vaccine in patients over 65 yrs is small it is still a reasonable option TGA is maintaining a very watchful eye on all new vaccines It is possible Australia will have 5 different vaccines available by the end of 2021 Host: Dr David Lim | Total time: 27 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST Tuesday 2 February 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
In this episode: Expect Mutations, current vaccines will give immunity to these new strains Even if it significantly alters the spike proteins, vaccines can be reformulated quickly Education is absolutely vital Who should and should not receive these vaccines What to be careful about - we must not mix vaccines as there are no studies to inform us We need a steady hand Host: Dr David Lim | Total time: 36 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST Tuesday 2 February 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
So far, tens of thousands of Connecticut residents have already received the COVID-19 vaccine. Yet nationally, vaccine rollout has been going slower than experts had hoped. This hour, we hear from reporters about how policies have shaped vaccine availability. And we get answers from a doctor about the science behind the shot. What questions do you have about the rollout of the COVID-19 vaccine? First, a group of frontline workers have written a book about their experiences during the COVID-19 pandemic. We hear from one of them. GUESTS: Claire Martin - Personal Care Attendant (PCA) from Middletown Nicole Leonard - Health care reporter for Connecticut Public Radio Lauren Weber - Midwest correspondent for Kaiser Health News Dr. Ellen Foxman - Assistant Professor of Laboratory Medicine and Immunobiology at Yale School of Medicine Support the show: http://wnpr.org/donate See omnystudio.com/listener for privacy information.
So far, tens of thousands of Connecticut residents have already received the COVID-19 vaccine. Yet nationally, vaccine rollout has been going slower than experts had hoped. This hour, we hear from reporters about how policies have shaped vaccine availability. And we get answers from a doctor about the science behind the shot. What questions do you have about the rollout of the COVID-19 vaccine? First, a group of frontline workers have written a book about their experiences during the COVID-19 pandemic. We hear from one of them. GUESTS: Claire Martin - Personal Care Attendant (PCA) from Middletown Nicole Leonard - Health care reporter for Connecticut Public Radio Lauren Weber - Midwest correspondent for Kaiser Health News Dr. Ellen Foxman - Assistant Professor of Laboratory Medicine and Immunobiology at Yale School of Medicine Support the show: http://wnpr.org/donate See omnystudio.com/listener for privacy information.
The Scott Thompson Show Podcast The federal government reached an agreement with Moderna that will see doses of its Covid-19 vaccine shipped to Canada within 48 hours of Health Canada approval. Meanwhile, Prime Minister Justin Trudeau says that 200,000 more doses of Pfizer-BioNtech vaccine will arrive in Canada next week. Guests: Dr. Eleanor Fish, Canada Research Chair in Women’s Health and Immunobiology and a Professor of Immunology with University of Toronto ThomasTenkate, Professor and Director, School of Occupational & Public Health, Ryerson University - The federal government says upgrades are necessary to Canada’s vaccine-tracking technology because of the “complex and fragile nature” of the COVID-19 vaccine, but it can’t explain why it started looking for a solution just weeks ago. Guest: David Hyde. Security Consultant, David Hyde & Associates - Outgoing U.S. President Donald Trump announced that one of his staunchest allies, Attorney General William Barr, is stepping down before Christmas. Guest: Reggie Cecchini, Washington Bureau Chief for Global News See omnystudio.com/listener for privacy information.
In this episode: Adverse reactions to the Pfizer BionTech vaccine have been reported and are expected, those with severe allergies advised not to receive this vaccine In Australia we will have the benefit of closely monitoring the experience of other countries; and a range of vaccines Even with vaccines, social distancing; hand washing and use of masks in at-risk venues will remain important Host: Dr David Lim | Total time: 27 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Tuesday 15 December 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
Dr. Sucharit Bhakdi is an American born physician trained in Germany and has been in the medical field now for five decades. He received his medical degree from the University of Bonn and did his post-doctoral work at the prestigious Max Planck Institute of Immunobiology and Epigenetics before becoming an associate professor at the Institute of Medical Microbiology at Gressen University. Later he was appointed as the chair of Medical Microbiology at the University of Mainz. Dr. Bhakdi has published over 300 articles in the fields of immunology, bacteriology and virology and has received numerous awards including the Order of Merit of Rhineland. His recent book, co-written with his biologist wife Dr. Karina Reiss -- "Corona False Alarm?: Facts and Figures," --- which has been written for the layperson to understand the pandemic clearly -- has already become a national best seller in Germany and is rapidly receiving international attention.
In this episode: There is no data on whether these vaccines will reduce transmission Cold chain logistics will restrict distribution of the mRNA (Pfizer, Moderna) vaccines to specialised centres rather than GP clinics Questions remain regarding young, elderly, immunocompromised, chronic disease Host: Dr David Lim | Total time: 28 mins Guests: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Tuesday 1 December 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
Sucharit Bhakdi is a Thai-German specialist in microbiology. He studied at the Universities of Bonn, Gießen, Mainz, and Copenhagen, and at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg. He is Professor Emeritus of Johannes Gutenberg University Mainz, and from 1991 to 2012 was head of the Institute of Medical Microbiology and Hygiene. His book, 'False Alarm', at Amazon: https://www.amazon.com/Corona-False-Alarm-International-Bestseller-ebook/dp/B08JCDV25M/ref=sr_1_1?dchild=1&keywords=bhakdi&qid=1606295985&sr=8-1
In this podcast episode, Dr. Akiko Iwasaki discusses the type of immune response developed in a person with COVID-19 as well as the role of the antibodies in the course of the pandemic and how the antibody tests can contribute to its management. About our Speaker: Dr. Akiko Iwasaki received her Ph.D. from the University of Toronto (Canada) in 1998, and her postdoctoral training from the National Institutes of Health (USA) (1998-2000). She joined Yale University (USA) as a faculty in 2000, and currently is the Waldemar Von Zedtwitz Professor in the Department of Immunobiology and a Professor in the Department of Molecular, Cellular, and Developmental Biology at Yale University. She is also a principal investigator at the Howard Hughes Medical Institute. Her research interests among others include innate immunity, T cell immunity and her research focuses on the mechanisms of immune defense against viruses at the mucosal surfaces. Her laboratory is interested in how innate recognition of viral infections lead to the generation of adaptive immunity, and how adaptive immunity mediates protection against subsequent viral challenge. Most recently, Dr. Iwasaki has delved into research looking at the immune response of COVID-19 patients and sex differences in SARS-CoV-2 infection. READING MATERIALS:• The New York Times. Your Coronavirus Antibodies Are Disappearing. Should You Care? July 27th/2020 https://nyti.ms/30U14v0 • The New York Times. Scared that COVID-19 Immunity won’t last? Don’t be. July 31st/2020 https://nyti.ms/2Pb6Dj1
In this episode: The mink mutation is a potentially serious issue, but for now seems to be contained Pfizer vaccine 90% effective? Probably not Host: Dr David Lim, GP | Total time: 30 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Tuesday 17 November October 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
In this week's episode, Brad speaks to the large body of research that has been done in the exercise immunology field and the great promise the field has to uncover with future research focal points. He highlights Dr. Richard Simpson PHD's article Titled: Exercise, Immunity, and the COVID-19 Pandemic. Dr. Simpson's research interests are concerned with the effects of aging, stress and exercise on the immune system. He is an associate professor in the Departments of Nutritional Sciences, Pediatrics and Immunobiology at the University of Arizona. You can read it in it's entirety here. https://www.acsm.org/blog-detail/acsm-blog/2020/03/30/exercise-immunity-covid-19-pandemic. It is a good read that lays out in layman's terms the impact that exercise has on our immune function. Simpson writes in his blog, "Having higher age and sex-adjusted scores for cardiorespiratory fitness and performing regular exercise of moderate- to vigorous-intensity exercise that fall within ACSM (American College of Sports Medicine) guidelines has been shown to improve immune responses to vaccination, lower chronic low-grade inflammation, and improve various immune markers in several disease states including cancer, HIV, cardiovascular disease, diabetes, cognitive impairment and obesity. The ongoing COVID-19 pandemic has raised a lot of questions regarding how exercise can protect us from infection by boosting immunity.” The blog also goes on to highlight: “Compounding this problem are the known negative effects of social isolation and confinement on immunity. Glucocorticoids such as cortisol are elevated during periods of isolation and confinement and can inhibit many critical functions of our immune system. When we are stressed, the ability of our T-cells to multiply in response to infectious agents is markedly reduced, as is the ability of certain effector lymphocytes (e.g., NK-cells and CD8+ T-cells) to recognize and kill cells in our body that have become cancerous or have been infected with viruses. It is also vitally important that our immune cells maintain their ability to redeploy so that they may ‘patrol' vulnerable areas in or body (e.g., the upper respiratory tract and the lungs) to prevent viruses and other pathogens from gaining a foothold. This process is also important to minimize the impact of the virus and to expedite viral resolution should we become infected. Brad gives tips to improving your cardiorespiratory fitness by getting your heart rate within 50-65% of your target heart rate max for 30-45 minutes for 3-5x/wk if not all days. If you are not sure how to calculate this, see the SportSquire Episode, The Benefits of Training Within Your Different Target Heart Rates. Brad continues to encourage the SportSquire Community to explore, engage, and learn as this is foundational to empowering real behavioral change on your wellness journey. He encourages those who are interested to look into some of the scholarly articles to read about the progressive research findings specifically related to Exercise Immunology. I hope you find this as a PROACTIVE tool during this time and meet your knowledge with your action! Be well!
In this episode: Practical implications- “keep washing your hands frequently” Why has fomite transmission not featured more prominently in recent outbreaks? Host: Dr David Lim, GP | Total time: 27 mins Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Register for our upcoming FREE WEBCAST! Tuesday 20 October 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.
In this Episode: Currently 11 in large phase 3 studies Will a moderately effective vaccine make any practical difference in Australia? What about the USA Efficacy vs immunogenicity Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services Total time: 28 mins FREE Webcast! Tuesday 6 October 7:00pm - 9:00pm AEDT Register Now! See omnystudio.com/listener for privacy information.
In this Episode: The AZ trial was suspended due to a single case of transverse myelitis… how many adverse events are tolerable before the trial will be cancelled? Some trial sites have NOT resumed, including the USA More transparency is needed for public confidence There are 14 vaccines currently in phase 3 clinical trials, approx 15 in phase 2, 27 in phase 1 and 92 candidates in animal (i.e. pre-phase 1) trials Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services Total time: 27 mins Free Webcast TONIGHT! Tuesday, 22 September 2020 7:00pm-9:15pm AEST Register Now! See omnystudio.com/listener for privacy information.
In this Episode: A vaccine by January is impossible Is fast tracking the vaccine evaluation going to create safety issues? Politicians are mistaking immunogenicity for efficacy Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services Total time: 20 mins FREE Webcast Tonight! Tuesday, 8 September 2020 7:00pm-9:15pm AEST Register Now! See omnystudio.com/listener for privacy information.
Henry Hakamaki joins Breht to discuss the latest science regarding SARS-Cov-2, how it impacts our immune system, how virus' work generally, the politics of it all, and much more. Support Henry's work HERE Follow Henry on Twitter HERE Please Support Rev Left Radio HERE Outro Music: 'The Devil Wears a Suit and Tie' by Colter Wall LEARN MORE ABOUT REV LEFT RADIO: www.revolutionaryleftradio.com
In this Episode: Which vaccines are likely to yield useful results soon? What is a molecular clamp? A viral vector? the nucleic acid (the RNA and DNA) vaccines? DNA vaccines - integration into host DNA is “the elephant in the room” Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services Total time: 34 mins FREE Webcast! Tuesday, 8 September 2020 7:00pm-9:15pm AEST Register Now! See omnystudio.com/listener for privacy information.
In this Episode: Phase 3 trials will be done by end of 2020. If it works it is likely to become available from mid 2021 Should it really be mandatory? The technology for this vaccine is very new so risk of adverse effects must be carefully assessed What if it is only partially effective or ineffective? What if it mutates? Which strains will it work for? Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing Expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Total time: 39 mins FREE Webcast! Tuesday, 25 August 2020 7:00pm-9:00pm AEST Register Now! See omnystudio.com/listener for privacy information.
In this Episode: The community doesn't understand asymptomatic spread Should Sydneysiders be using masks more widely? The VIC situation is very worrying, a stage 4 lockdown seems like the only option Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services. Total time: 36 mins FREE Webcast Today! Tuesday, 28 July 2020 7:00pm-9:00pm AEST Register Now! See omnystudio.com/listener for privacy information.
In this bonus episode of Where Cures Begin, we hear about the parallels between polio and COVID-19, and how Salk is responding to the pandemic, from faculty in Salk's NOMIS Center for Immunobiology and Microbial Pathogenesis. Professor Susan Kaech aims to understand how memory T cells are produced during infection and vaccination, how they function and why they can fail to induce long-term immunity, particularly during chronic disease or cancer. Professor Greg Lemke discovered a family of proteins called TAM receptors, which play a crucial role in regulating the response of the immune system to infection from bacteria, viruses and other pathogens. Professor Martin Hetzer is Salk's VP/CSO, responsible for providing leadership in developing and implementing Salk’s overall scientific strategy, as well as overseeing research operations in support of that strategy. Additionally, his lab uses a variety of techniques to pose questions about how the human genome is organized inside a cell’s nucleus.
In this Episode: Is the situation under control in the USA? What about South America? Implications for the rest of the world Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific Services Total time: 18 mins See omnystudio.com/listener for privacy information.
In this Episode: Studies on how long the virus survives on surfaces are often very misleading More advice on masks, gloves and hygiene Dental procedures Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services. Total time: 23 mins See omnystudio.com/listener for privacy information.
A look at the most promising vaccines about to enter human trials Human trials are just the beginning of an extremely complicated process Even if the human trials are successful, it doesn't mean it works Host: Dr David Lim, GP Guest: Dr Gary Grohmann, Virologist; Vaccine Manufacturing expert; Former Director of Immunobiology and WHO ERL at the TGA, Office of Laboratories and Scientific services. Total time: 30 mins See omnystudio.com/listener for privacy information.
Professor John Hogenesch studies circadian rhythms and the genome. He talks about The influence of cues on our circadian rhythm and how lighting and even medication timing can affect us, Studies on hospital-specific lighting and how two new hospital wings in Cincinnati are designed accordingly, and Some unusual sleep patterns, such as Delayed Sleep Phase Syndrome, and how it can affect people. Dr. John Hogenesch is Professor of Pediatrics at Cincinnati Children's Hospital Medical Center in Human Genetics and Immunobiology at the University of Cincinnati Department of Pediatrics. He specializes in genome biology with a focus on the molecular mechanisms of circadian rhythms in mammals. He explains to listeners the basics of circadian rhythm as a daily rhythm of behavior and physiology that persists in the absence of external cues. He discusses how healthcare and specifically hospital design and schedules are often at odds with most patients' rhythms. In fact, he mentions one study in which NICU patients under a cycled light schedule went home two weeks earlier than babies under constant dimmed light conditions. He discusses his hospital's design of two new areas for NICU and PICU patients under the advisement of his lab that will integrate beds with circadian natural-light systems. He adds ways in which medication delivery and procedure timing could also be better paired with circadian rhythms and efforts to do so. Dr. Hogenesch also talks about Delayed Sleep Phase Syndrome (DSPS). Richard has such a sleep pattern and the two discuss how it manifests itself, as well as other sleep patterns, and how they affect those who experience them. He also addresses how cortisol's peak has an effect as well as how external cues interfere or work with our sleep patterns. For example, he mentions our eating timing, light exposure, and light temperature and type. He discusses how the pandemic is pushing many of us to later sleep schedules and possible hypothesizes for why. Along the way he offers some suggestions for eliminating excessive blue and green light and other similar measures. For more, see his lab page at cincinnatichildrens.org/research/divisions/h/genetics/labs/hogenesch and the Society for Research in Biological Rhythms, which publishes helpful blog posts and articles. Available on Apple Podcasts: apple.co/2Os0myK
University of Arizona's Head of Immunobiology, Dr. Janko Nikolich-Zugich discusses the importance of slowing down the spread of COVID-19 and more importantly immunity to the virus. Dr. Janko reiterates, following social distancing and personal protection guidelines extends time for experts to find and begin early treatments.
Sonja Schrepfer Bio: Sonja Schrepfer, M.D., Ph.D., Professor of Surgery, founded the Transplant and Stem Cell Immunobiology (TSI) Lab in 2009 in Germany. In 2015, she joined the faculty of the Department of Surgery at the University of California San Francisco and was Director of the TSI Lab at UCSF. Sonja is scientific co-founder of Sana Biotechnology Inc. which she joined as SVP in 2019. Dr. Schrepfer's research career has been dedicated to making fundamental discovers in transplant and stem cell immunobiology. Pluripotent stem cell (PSC)-based approaches are effective in immunosuppressed/deficient animal models; but in humans, systemic immunosuppression cannot be justified, due to severe side effects and significant risk of infections and malignancies. So far, only a few immunological strategies have been proposed to overcome these hurdles. Work by Dr. Schrepfer is at the forefront of PSC immunobiology and paves the way for treatment of a wide range of diseases – from supporting functional recovery of failing myocardium to the derivation of other cell types to treat diabetes, blindness, cancer, lung, neurodegenerative, and related diseases. She spent many years examining in detail the fetomaternal interface for application to the envisioned cell therapy. Her work with one of the most antigenic phenotypes, antigen-presenting endothelial cells, demonstrates that hypo-immunogenic cells reliably evade immune rejection in allogeneic recipients that are entirely mismatched in their major histocompatibility complex profile, and further, these cells show long-term survival without immunosuppression in mice and humanized mice (published in Nature Biotechnology in 2019). Sonja is currently Adjunct Professor at UCSF investigating the immunobiology in “tissue chips in space”; that is sending tissue chips to the international space station (ISS). She participated in three flight missions as collaborator and was the PI on the SpaceX16 mission (December 2019). This research will provide insight into what physiological effects time in outer space might have on astronauts, with potentially important implications for future longer-term missions, and has the possibility to open the door to fascinating new discoveries that could be used in earth-bound immunology research. Tobias Deuse Bio: Tobias Deuse, M.D. is a cardiac and heart and lung transplant surgeon internationally renowned for his pioneering work in the development of minimally-invasive techniques for mitral valve repair. Dr. Deuse graduated the University of Stuttgart (Germany) in 1994 with a BS in Physics, and in 2000 earned an M.D. from University of Wuerzburg. Dr. Deuse thereafter received advanced training in cardiothoracic surgery at the University Hospital Munich-Grosshadern and University Heart Center Hamburg-Eppendorf. After obtaining his board certification in Germany in 2007 as a heart surgeon, Dr. Deuse completed a surgical fellowship in Lung and Heart-Lung Transplantation at Stanford and joined the UCSF faculty in 2015. Dr. Deuse's laboratory at UCSF is working on the immunobiology of pluripotent stem cells. To circumvent rejection, techniques such as somatic cell nucleus transfer (SCNT) into an enucleated oocyte (formation of a SCNT stem cell), fusion of a somatic cell with an embryonic stem cell (ESC; formation of a hybrid cell), and reprograming of somatic cells using certain transcription factors (induced PSCs, iPSCs) have been used. However, his work has shown that SCNT stem cells and iPSCs may have immune incompatibilities with the nucleus or cell donor, respectively, despite having identical nuclear DNA (published in Cell Stem Cell 2014). Further, he has demonstrated that mitochondrial (mt) DNA-encoded proteins as well as mtDNA mutations and genetic instability associated with reprograming and iPSC expansion can create minor antigens, producing rejection. His work also demonstrated that even autologous iPSC derivatives are not inherently immunologically inert for autologous transplantation (published in Nature Biotechnology in 2019). This has provided an important, promising avenue for selection of optimal stem cell therapeutics for future clinical applications ¾ via identifying the most compatible starter cell line and monitoring “near match” autologous iPSC products for mtDNA mutations and single nucleotide polymorphism (SNP) enrichments during the manufacturing process. Director Sonja Schrepfer, M.D., Ph.D., and co-director Tobias Deuse, M.D., explain the lab's research towards understanding and overcoming transplant rejection. They touch on Why finding ways to reduce rejection and successfully find transplantation avenues that don't require immunosuppression drugs is so important, How their research starts with pluripotent stems cells that must be differentiated and then transplanted, Why using a patients' specific stem cells still face rejection due to mitochondrial proteins that eventually form despite gene editing, and How the lab is working toward an "off the shelf" solution by altering proteins that trigger rejection and other means. Drs. Schrepfer and Deuse run the Transplant and Stem Cell Immunobiology Lab (TSI) at the University of California in San Francisco and specialize in heart and lung transplant issues through CRISPR, gene editing,and stem cell therapy. They begin by explaining the many complications a person taking immunosuppressant drugs faces and why their research seeks to address these issues and make for a safer system for patients. Further, they explain that patient-tailored stem cell therapy approaches are not suitable for large populations for several reasons, including the frequent need to treat a patient almost immediately for heart damage or other similar issues. They explain that while they can generate cardiac cells that don't get rejected at first, these cells can develop mutant proteins that causes rejection later. They are following a couple of approaches to address the rejections including learning how fetuses survive the mother's immune system. A big leap forward for the lab was learning how to knock out the molecule that signaled to the immune system its foreignness through CRISPR: in other words, they are learning how to make these introduced cells silent to the immune system. Finally, they describe their "off the shelf" goal of producing non-immunogenic cells ready for injection for a majority of patients and alternatively generating a hypo-immunogenic environment in the patient to prevent long-term rejection. For more, see the lab's web page at https://tsilab.ucsf.edu/
COVID-19 has dominated our lives, but how much do you actually know about the virus that causes this disease? This hour, we talk with NY Times columnist and writer, Carl Zimmer about the science behind the coronavirus. We learn about how viruses work and how they’re different from other disease-causing germs like bacteria. A Yale immunobiologist also joins us as we learn about the strategies researchers are taking to find and develop treatments and vaccinations. What questions do you have about how the medical and scientific community is confronting the COVID-19 pandemic? We want to hear from you. GUESTS: Carl Zimmer - New York Times columnist and the author of 13 books about science, including A Planet of Viruses (@carlzimmer) Dr. Ellen Foxman - Assistant Professor of Laboratory Medicine and Immunobiology at Yale School of Medicine and Assistant Director of the Yale New-Haven Hospital Clinical Virology and Clinical Immunology Laboratories (@EllenFoxman) Support the show.
In this episode of the Epigenetics Podcast, we caught up with Dr. Andrew Pospisilik from the Van Andel Institute in Grand Rapids, Michigan to talk about his work on the epigenetic origins of heterogeneity and disease. Dr. Andrew Pospisilik worked at the Max-Planck Institute of Immunobiology and Epigenetics in Freiburg for 8 years and in 2018 he joined the Van Andel Institute as the director of its Center for Epigenetics. At the Van Andel Institute his research focuses on diabetes, neurodegenerative diseases, cancer, and obesity. The goal of the Pospisilik laboratory is to better understand epigenetic mechanisms of these diseases and the roles of epigenetics in disease susceptibility and heterogeneity. These areas of medicine are among the most important public health challenges, with the latest estimates suggesting that they impact more than 1 billion people worldwide. Although these diverse conditions are all very different, they are now thought to be caused, at least partially, from alterations in the epigenetic mechanisms that regulate gene expression and metabolism. This interview covers recent work from the Pospisilik lab on the epigenetics of these complex diseases. References https://pospisiliklab.vai.org/ J. Andrew Pospisilik, Daniel Schramek, … Josef M. Penninger (2010) Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate (Cell) DOI: 10.1016/j.cell.2009.12.027 Anita Öst, Adelheid Lempradl, … J. Andrew Pospisilik (2014) Paternal diet defines offspring chromatin state and intergenerational obesity (Cell) DOI: 10.1016/j.cell.2014.11.005 Kevin Dalgaard, Kathrin Landgraf, … J. Andrew Pospisilik (2016) Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity (Cell) DOI: 10.1016/j.cell.2015.12.025 Tess Tsai-Hsiu Lu, Steffen Heyne, … J. Andrew Pospisilik (2018) The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes (Cell Metabolism) DOI: 10.1016/j.cmet.2018.04.013 Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on Linked-In Active Motif on Facebook eMail: podcast@activemotif.com
In episode 259 of The Real Food Reel we are joined by Bill Giles, imunobiologist, yoga instructor, martial arts enthusiast, and advocate for people being responsible for their health through diet, exercise and mental wellbeing. Bill and I explore the potential triggering of chronic illnesses as people age, the impact of plant-derived foods and drinks from a biological perspective, all about grains including the long-term advantages of grain-free living, what inspired Deeks and so much more. Deeks Health Foods: https://deeks.com.au Click below to download transcript: The post RFR 259: Immunobiology, Lectins & the Carnivore Diet with Bill Giles appeared first on The Wellness Couch.
"Bob Walker & Cathy Almquist with Trident Technical College: Powering Workforce Development” Supply Chain Now Radio, Episode 180 Live from the 2019 SCAC AIAG Supply Chain & Quality Conference In Charleston, South Carolina This episode features Bob Walker and Cathy Almquist. Bob Walker is the Vice President for Continuing Education & Workforce Development. He earned his Bachelor of Science in Electrical Engineering from The Citadel and his Master of Engineering from the University of South Carolina. Bob also earned his A.I.T. in Aircraft Maintenance Technology from Trident Technical College. Learn more about Trident Tech here: https://www.tridenttech.edu/ Cathy Almquist is the Vice President for Academic Affairs at Trident Technical College. She has been with the college since 1990 when she joined the faculty as a chemistry instructor. She holds an Associate in Arts from Iowa Western Community College, a Bachelor of Science in Chemistry from the College of Charleston, a Master of Science in Immunobiology from Iowa State University, and a Doctor of Management in Community College Policy and Administration. Learn more about Trident Tech here: https://www.tridenttech.edu/ Upcoming Events & Resources Mentioned in this Episode: Help with Hurricane Dorian Relief: https://www.alanaid.org/ Connect with Bob on LinkedIn: https://www.linkedin.com/in/walker-bob-95802414/ Connect with Cathy on LinkedIn: https://www.linkedin.com/in/catharine-almquist-d-m-70574357/ Connect with Beau on LinkedIn: https://www.linkedin.com/in/beaugroover/ Connect with Greg on LinkedIn: https://www.linkedin.com/in/gswhite/ Connect with Scott on LinkedIn: https://www.linkedin.com/in/scottwindonluton/ SCNR to Broadcast Live at SC Logistics 2019 Fall Tech Talk: https://tinyurl.com/y2mttrg8 eft Logistics CIO Forum in Austin, TX: https://tinyurl.com/y5po7tvw Reverse Logistics Association Conference & Expo: https://rla.org/calendar/1 SCNR to Broadcast Live at MODEX 2020: https://www.modexshow.com/ SCNR on YouTube: https://tinyurl.com/scnr-youtube Check Out News From Our Sponsors: The Effective Syndicate: https://www.theeffectivesyndicate.com/blog Spend Management Experts: https://spendmanagementexperts.com/ APICS Atlanta: https://apicsatlanta.org TalentStream: https://talentstreamstaffing.com/ Verusen: https://www.verusen.com/ Georgia Manufacturing Alliance: https://www.georgiamanufacturingalliance.com/ ProPurchaser.com: https://tinyurl.com/y6l2kh7g Supply Chain Real Estate: https://supplychainrealestate.com/ Vector Global Logistics: http://vectorgl.com/ This episode was hosted by Scott Luton, Greg White, and Beau Groover of the Effective Syndicate. For more information on this episode, please visit our dedicated show page at: www.supplychainnowradio.com/episode-180
Kylie is a senior at the University of Arizona studying Neuroscience and Molecular & Cellular Biology with a minor in…
Can Genistein Help Heal Hashimoto’s Disease and Hypothyroidism? In the fall of 2016, a study was conducted in China and published in the medical journal Immunobiology. The researchers looked at the compound genistein and Hashimoto's disease to see if it affected thyroid function in patients with Hashimoto’s thyroiditis. The research paper was entitled, “Genistein improves thyroid function in Hashimoto’s thyroiditis patients through regulating Th1 cytokines.” To clarify, “Th1 cytokines” refer to a type of thyroid-helper cells that indicate how much inflammation there might be in the thyroid gland. In other words, they are markers of inflammation. The results of this study were very exciting so you might want to pay close attention. What is genistein? Genistein is an isoflavone which is a plant-derived compound with estrogenic activity. It falls in the class of phytoestrogens and is found in soybeans. Clinical studies in the past have demonstrated that this compound has immune-regulating properties by exerting anti-inflammatory effects in certain health conditions including encephalomyelitis (inflammation of the brain and spinal cord), cardiac inflammation resulting from diabetes, coronary obstructive pulmonary disease (COPD) and other serious diseases. In this study, Zhang and four of his colleagues began by pointing out that Hashimoto’s thyroiditis is now considered the most common autoimmune disease in the world. It is believed that excessively stimulated thyroid-helper cells play the main role in giving rise to the autoimmune condition in Hashimoto’s thyroiditis patients. While conventional treatment has typically addressed only the symptoms of the illness via oral administration of a thyroid hormone replacement, the fact remains that there is still an autoimmune condition in Hashimoto’s thyroiditis which can be a concern. Why is it problematic for an autoimmune condition to persist in an individual with Hashimoto’s disease? Previous studies have demonstrated that in those with fully or partially functional thyroid glands but not “fully hypothyroid Hashimoto’s patients”, long-term Hashimoto’s thyroiditis closely correlated with the prevalence of thyroid cancer. Chronic inflammation is never beneficial for the body so if someone is invested in his or her health, mitigating any autoimmune condition would be prudent. In this investigation, the researchers wanted to evaluate any beneficial anti-inflammatory properties of genistein for those with Hashimoto’s thyroiditis and examine what impact it might have on the chronic inflammatory condition associated with Hashimoto’s disease. How was the study done? Two-hundred eighteen female subjects between the ages of 20 and 80 were recruited, all with Hashimoto’s thyroiditis. These requirements had to be met in the subjects: 1. Normal levels of free T3 and free T4 with or without thyroid replacement therapy 2. Normal TSH levels or slightly elevated TSH levels below 20 mU/L 3. Increased blood levels of thyroid antibody (thyroid peroxidase) greater than 100 U/mL Subjects with any of the following conditions were excluded: 1. Prior use of immunoregulators 2. Presence of infection 3. Presence of thyroid nodules 4. Thyroid hypoplasia 5. Prior treatment with radioiodine 6. Pregnancy 7. Presence of serious illnesses such as cancer, kidney or liver failure. The 278 females with Hashimoto’s were split into two groups with 143 in the placebo group and 135 in the genistein group. Patients in the genistein group were given 600 mg per day of genistein as a purified soy extract taken orally for thirty days. What lab work was required? To measure thyroid function: 1. TSH 2. T3 3. T4 (total T4) 4. fT4 (free T4) To measure thyroid antibody levels: 1. Thyroid peroxidase - TPOAb 2. Thyroglobulin – TgAb To measure inflammation: Thyroid-helper cell bodies (Th1 and Th2) which we will refer to henceforth as inflammatory markers.
YJBM editors and podcast hosts chat with David Hafler, the Chair of the Department of Neurology and Professor of Neurology and Immunobiology at Yale, about the connection between food and metabolism, the nervous system, and the immune system for our second episode about food and nutritional science.
Dr. Adrienne Randolph, Senior Associate in Critical Care Medicine, and Director of the Immunobiology of Critical Illness Laboratory at Boston Children’s Hospital, and Professor of Anesthesia and Pediatrics at Harvard Medical School, discusses recent developments and progress in the diagnosis and classification of pediatric sepsis. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
In this edition of NCTalks, we speak to Robyn Klein, a Professor of Medicine, Immunobiology and Neuroscience at Washington University School of Medicine in St Louis, Missouri in the USA. Robyn’s research focuses on the pathogenesis of neuroinflammatory diseases in the CNS, specifically the mechanism of leukocyte recruitment into the CNS, and the direct effects of inflammatory mediators on resident neural cells. In this interview, we ask Robyn about her work in this area as part of our Spotlight on neuroimmunology – we’ll discuss Robyn’s research, how inflammatory processes contribute to neurologic disease, and whether immunology and inflammation could be the basis of an eventual preventative treatment for neurodegenerative diseases such as Alzheimer’s. You can find more podcasts, articles and news at www.neurology-central.com
Ante un golpe o inflamación, pensamos que un medicamento es la mejor forma para reducir la inflamación y curar más rápido el golpe pero lo que no sabemos es que hay remedios naturales que nos pueden ayudar mucho a reducir la inflamación de una determinada zona y además nos evitaran problema secundarios en el estómago, sistema digestivo, etc. Desde un dolor de cabeza pasando por dolor de espalda, esguinces, migrañas, osteoartritis, etc. podemos reducir el dolor y la inflamación de forma natural con plantas medicinales. En función del tipo de elemento del que se componga, podemos encontrar inflamatorios naturales como alimentos para comer, cremas para ponernos en la zona afectada o incluso en forma de té para tomar calentito cuando deseemos. Para hablaros de todos ellos nosotros hemos clasificado los antiinflamatorios en los siguientes tipos: El primero de los que vamos a hablar son las plantas, que sirven de base para hacer cremas antiinflamatorias naturales como la crema de árnica Galius o sirven para hacerse tés caseros. Y alimentos con propiedades antiinflamatorias para que los podáis añadir a vuestra dieta. Comencemos: Cúrcuma Esta especia está formada principalmente por un componente activo llamado curcumina. La curcumina es un colorante natural procedente de la cúrcuma. Algunos de los productos en los que la podemos encontrar como colorante son: mantequillas, quesos, productos de pastelería y licores. El colorante de la cúrcuma se absorbe relativamente poco en el intestino, y lo que es absorbido se elimina rápidamente por vía biliar, por ello se combina (casi en cantidades iguales) con pimienta negra que aumenta 2000 veces su absorción. Alta acción antiinflamatoria y analgésica que puede ayudar a aliviar diferentes patologías. Las propiedades antiinflamatorias de la cúrcuma hacen de esta planta un remedio efectivo para aliviar los síntomas y el dolor de afecciones como: 1. La artritis reumatoide. 2. Osteoartritis. 3. Colitis ulcerosa. 4. Uveitis anterior crónica. 5. Dolor en las articulaciones. 6. Dolores de espalda. Mejora la digestión Cuenta con propiedades carminativas gracias a agentes activos como el eugenol y el zinzibereno, los cuales ayudan a aliviar cólicos flatulentos al estimular la eliminación de gases del intestino. En particular, la cúrcuma está considerada como una especia digestiva, ya que estimula la secreción de moco gástrico y mejora la digestión de los alimentos. Protege de enfermedades cardiovasculares Tiene propiedades cardioprotectoras al disminuir los efectos del estrés oxidativo causado por los radicales libres. Su capacidad para incrementar las enzimas antioxidantes podría ser beneficiosa para reducir el riesgo de desarrollar enfermedades del corazón. También ha demostrado evitar la coagulación de la sangre, lo que ayuda en la prevención de enfermedades como la aterosclerótica vascular o la aterosclerosis. Apoyado con una buena alimentación, su consumo podría resultar bueno para controlar los niveles de colesterol y triglicéridos. Protege el hígado Antidepresivo Fortalece las defensas del cuerpo Es una fuente de vitaminas y minerales que fortalecen el sistema inmunológico para aumentar las defensas contra los virus y bacterias que causan infecciones. Harpagofito El Harpagofito, también conocido popularmente como garra del diablo o uña del diablo, es una planta originaria de África, que contiene varios principios activos que son los que le confieren sus propiedades medicinales. Algunos de estos componentes son los iridoides, triterpénicos, flavonoides o fenilpropanos. Esta planta medicinal tiene acción digestiva, antiinflamatoria, analgésica, colérica, depurativa, antimiálgica, antifebril, antidiabética, estimulante del apetito, hipoglucemiante, antioxidante. Usos y beneficios del Harpagofito • Mejora las digestiones • Alivia los dolores • Es efectiva para el dolor de cabeza • Es beneficioso para la vejiga • Reduce el colesterol en sangre • Mejora el movimiento articular • Ayuda a evitar la arterioesclerosis • Está indicada para problemas gastrointestinales • Depura el organismo • Reduce los niveles de azúcar en sangre • Reduce la inflamación y la hinchazón • También combate la arteriosclerosis, la artralgia y el reúma. En casos de osteoartritis se combina con el ácido hialurónico, un polisacárido de poder regenerador. Arnica El árnica normalmente se puede encontrar en forma de pomada, crema, gel o aceite, y se utiliza para la curación de moretones, esguinces, dolor de músculos, hinchazones y en general, cualquier problema que esté relacionado con los huesos, los tendones o los músculos. Composición: • Aceites esenciales constituidos por esteres dimetílicos. Colina, mucílago, betaína y arnicina. • Laurato y palmitato de metilo. • Helenalina y terpeno tinol que son lo mayores responsables de sus propiedades antiinflamatorias y antisépticas. • Flavonoides - Los flavonoides son pigmentos naturales presentes en los vegetales y que protegen al organismo del daño producido por agentes oxidantes, como los rayos ul- travioletas, la polución ambiental, sustancias quími- cas presentes en los alimentos, etc • Y es rica en carotenos. El árnica cuenta con las siguientes propiedades: Propiedades analgésicas del árnica. Nos ayudan a aliviar el dolor de esguinces, contusiones y otras lesiones. Propiedades antiinflamatorias del árnica. Explican por qué esta planta medicinal ayuda a desinflamar y reducir la hinchazón temporal de las lesiones, así como los moretones. Esto se debe a que contiene un compuesto llamado helenalina. Propiedades antimicrobianas del árnica. La hacen muy útil para combatir irritaciones menores de la piel. Beneficios del Árnica Algunos estudios sugieren que además de las utilidades más conocidas como las de aliviar el dolor, la hinchazón y los moretones, el árnica puede ser útil también para tratar el dolor y la hinchazón propios de la post-cirugía, aliviándolos de manera leve pero significativa. Se pueden aprovechar las propiedades antibióticas de esta esta planta medicinal para tratar problemas de boca mediante enjuagues y gárgaras, teniendo la precaución de no tragar ni ingerir el producto. Para qué Sirve el Árnica Aplicado externamente en forma de crema, pomada, gel o aceite (no por vía oral), el árnica se utiliza para: Golpes o contusiones: Su uso previene la aparición de hematomas, chichones y disminuye el dolor Congelaciones: Si se han producido ampollas no abiertas, la crema de árnica tiene propiedades antiinflamatorias y antibacterianas que ayudarán a reducir la sensación de dolor • Desgarros o distensiones y dolores musculares • Moretones en los ojos • Esguinces y luxaciones • Artritis reumatoide • Estrías del embarazo • Úlceras no abiertas, eccemas de le piel y acné • Cuidado del cabello mediante la elaboración de champús naturales • Enjuagues bucales con el objetivo de curar las aftas en la boca, los problemas de las encías o la piorrea de los dientes • Realizando gárgaras podemos eliminar las bacterias que afectan a la garganta y que producen afecciones como la faringitis o las anginas • Lavados de la zona genital en caso de picor vaginal Otras plantas: Verbena , Laurel y Corteza de sauce blanco ALIMENTOS QUE FUNCIONAN COMO ANTIINFLAMATORIOS NATURALES La clara de huevo tiene una acción antiinflamatoria por su contenido y proporción de aminoácidos. El huevo entero ecológico es también muy saludable por su contenido en grasas, proteínas, vitaminas y minerales. contiene cantidades considerables de nutrientes básicos como: proteínas de alto valor biológico, vitaminas A, D, E y grupo B, zinc y selenio. Tiene especial interés el contenido en vitamina D por el reducido número de alimentos que la contienen. La grasa de los huevos es en primer lugar omega 9 (oleico), a continuación, saturada y en menor cantidad omega 6 y omega 3. Además, contiene hierro. Las yemas de huevo están repletas de los poderosos antioxidante colina. En la investigación realizada por el Instituto de Genómica y Biología Integrativa de la India y publicado en julio de 2010 en "Immunobiology", los investigadores encontraron que la colina reduce la inflamación en todo el cuerpo. Aceite de pescado Los ácidos grasos Omega 3 bloquean la producción de sustancias químicas inflamatorias, tales como las citoquinas, prostaglandinas, leucotrienos o eicosanoides. Cereales integrales Una de las grandes diferencias entre los productos integrales y los refinados son su contenido en fibra. Así mismo, una dieta rica en fibra ha demostrado que reduce los niveles de la proteína C reactiva producida por el hígado. Proteína indicadora de la inflamación en sangre. Jengibre Reduce la inflamación intestinal ya que sus propiedades suprimen la síntesis de prostaglandina (que produce vasodilatación y dolor) de una forma muy similar a los fármacos antiinflamatorios no esteroideos. Vegetales verdes Nos referimos principalmente a aquellos vegetales ricos en vitamina E dado que una de las principales funciones de esta vitamina es la de proteger al organismo contra moléculas antiinflamatorias llamadas citosinas. Ajo y cebolla Estas hortalizas actúan de forma parecida a los medicamentos para el dolor como el ibuprofeno desactivando las vías que dan lugar a la inflamación. La cebolla contiene agentes químicos anti-inflamatorios como el flavonoide denominado quercetina y el ajo un compuesto llamado alicina. Piña Es un pontente antioxidante, rica en fibre. Además contiene bromelina, una enzima que tiene una acción antiinflamatoria, antitumoral, antiedematosa, además de ayudar a la digestión y mejorar el sistema circulatorio y bascular. Otros alimentos: almendras, soja, frambuesas, arándanos, cerezas, fresas, pimientos, pescado azul, remolacha o tomates.
What has the microbiome taught us? In the second episode on the microbiome, we are joined by Yale rheumatologist and assistant professor of Immunobiology and Medicine, Dr. Martin Kriegel to discuss articles published in our issue, current research on the microbiome, how the microbiome is being applied in the clinic, and where the future of … Continue reading Microbiome: Episode II →
Dr. Mike Gilmore is the Sir William Osler Professor of Ophthalmology, and Microbiology and Immunobiology at Harvard Medical School. Dr. Gilmore is the director of the Harvard-wide Program on Antibiotic Resistance, and his research focuses on the evolution and development of multidrug resistant strains of enterococci, staphylococci, and streptococci. The world is facing a serious health crisis with the increasing prevalence of multidrug resistant superbugs; the CDC estimates that there are 2 million infections and 23,000 deaths each year in the U.S. due to antibiotic resistant bacteria. Dr. Gilmore discusses how bacteria become resistant to antibiotics, what scientists are doing to address this problem, and what everyone can do to help alleviate this impending global health crisis. Discussants (in alphabetical order): Dr. Karl Klose (Professor and director of STCEID, UTSA) Dr. Janakiram Seshu (Associate professor, STCEID, UTSA) Dr. Floyd Wormley (Professor, STCEID, UTSA)
Regenerative Medicine Today welcomes Dr. Tarek Fahmy. Dr. Fahmy is an Associate Professor of Biomedical Engineering and Immunobiology at Yale University. Dr. Fahmy discusses his research in biomaterials for drug and antigen delivery to the immune system. For more information about Dr. Fahmy, click here. Host John Murphy. For more information about the [...]
I got interested in this topic last year when the Yale Medical School got a $10 million Blavatnik grant for more work in the specific area of Immunobiology.Support the show: http://www.wnpr.org/donateSee omnystudio.com/listener for privacy information.
Symposia on Cancer Research 2012: Immunology and Inflammation in Cancer
Lieping Chen, M.D., Ph.D., Yale University School of Medicine, New Haven, Connecticut
Symposia on Cancer Research 2012: Immunology and Inflammation in Cancer
Lieping Chen, M.D., Ph.D., Yale University School of Medicine, New Haven, Connecticut
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 12/19
Thu, 7 Oct 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/12673/ https://edoc.ub.uni-muenchen.de/12673/1/Grinninger_Carola.pdf Grinninger, Carola ddc:610, ddc:600, Medizinische Fakultät
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06
This study investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease course of secondary progressive MS, albeit in a strongly abbreviated time course (Figure 3.1.1). This study demonstrates that MOG-specific autoantibodies are responsible for initiating clinical relapse and driving disease progression. On the background of mild, sub-clinical inflammatory activity in the CNS, pathogenic antibodies enter the CNS and mediate demyelination, a process that in turn amplifies the local inflammatory response (Figure 3.1.14 A). It should however be noted that lethal clinical relapses may also occur in the absence of a pathogenic antibody response if an inflammatory lesion develops in a region of the CNS that is particularly sensitive to damage, or where it may perturb vital functions, such as the brain stem. Although antibodies have been shown to amplify the severity of ongoing clinical EAE (Schluesener et al., 1987; Linington et al., 1988; Lassmann et al., 1988), firm evidence for a role in driving relapse and disease progression was missing. This study has now established this principal, which in all probability is relevant to our understanding of the pathogenesis of severe, steroid non-responsive relapses in MS patients. However, this model of EAE is an artificial system, in which the role of antibody is only apparent because of the different kinetics of MOG-specific T and B cell responses. In MS we still have to answer two crucial questions, namely the identity of the autoantigens targeted by the demyelinating antibody response, and the factors that may trigger this response. MOG is the only myelin protein known to initiate a demyelinating antibody response in EAE, and MOG-induced EAE has provided a valuable tool to identify the role of pathogenic autoantibodies in immune mediated demyelination. However, there is a major discrepancy between the proportion of MS patients with pathogenic MOG-specific antibodies in their circulation (5%; Haase et al., 2000) and the frequency of patients with pathological changes suggestive of antibody-mediated pathomechanisms (>50%; Lucchinetti et al., 2000). This discrepancy may in part be accounted for by the absorption of the pathogenic antibodies into the CNS, which will lead to a dramatic reduction of the antibody titre in the periphery, as demonstrated in section 3.1.3.4 of this study. On the other hand, it is unlikely that MOG is the only target autoantigen, which is exposed on the myelin surface and can therefore initiate a demyelinating autoantibody response. The identification of potential targets is a prerequisite to develop diagnostic kits to identify those patients with pathogenic autoantibody responses and then provide an appropriate therapy such as plasma exchange, or immuno-absorption. As demonstrated in this study, DNA vaccination using a plasmid encoding a myelin antigen is one approach to generate high titre autoantibody responses directed against the native protein. The pathogenicity of this antibody response can then be assayed in the same animal by inducing EAE. This method circumvents problems such as purity, yield and denaturation, all of which complicate any study using antigens isolated from the CNS or generated using recombinant technologies. Coupling this approach to a proteomics based analysis of the myelin membrane and reverse genomics to identify candidate gene products provides the means to map out those protein antigens that can be targeted by a demyelinating autoantibody response. The feasibility of this concept is currently being tested in the rat using PLP and MAG as myelin components that may in certain circumstances provoke a pathogenic autoantibody response. Such an analysis will, however, not detect pathogenic antibody responses to glycolipid antigens, which are major target autoantigens in a number of diseases affecting the peripheral nervous system such as Guillain Barré syndrome (GBS). In GBS a pathogenic antibody response to gangliosides appears to be triggered by infections with particular serotypes of Campylobacter jejuni (Fredman, 1998; Willison and O´Hanlon, 1999). In the majority of patients these antibody responses are an acute phenomenon and disappear as the patients recover (Hahn, 1998). It is conceivable that a similar mechanism is responsible for the initiation of severe relapses in some MS patients, if an infection triggers a cross-reactive antibody response to a surface glycolipid epitope. This would induce an episode of acute CNS demyelination that would not be immediately responsive to immunosuppressive therapy, as tissue damage and amplification of the local inflammatory response would be driven by the pre- existing antibody response. Analysis of the autoantibody responses in MS should therefore be extended to examine lipid as well as protein autoantigens. Such studies should also not be restricted to myelin, but also address the question of responses to other structures such as the axon and oligodendrocyte progenitor cells. Such autoantibody responses are however only conditionally pathogenic, in other words their pathogenic potential is only expressed if they can enter the CNS across the blood brain barrier (BBB)(Litzenburger et al., 1998; Bourquin et al., 2000). In EAE the inflammatory insult to the CNS is responsible for the disruption of BBB function and the entry of antibody into the nervous system. MS is characterised by repeated episodes of CNS inflammation but what initiates and maintains this response is unclear. The observation, that DA rats develop a similar, although eventually self-limiting response in the CNS after immunisation with MOG-peptide in CFA provides a model to investigate the immuno-regulatory deficit(s) responsible for chronic CNS inflammation. The disease model is very reproducible with >90% of animals relapsing after peptide immunisation as opposed to
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