POPULARITY
4 episodes with applied microbiology
4 episodes with applied microbiology
3 episodes with applied microbiology
2 episodes with applied microbiology
Alexandra C. Melo (PhD) is a Homeopath and Microbiologist (PhD) practicing in London and worldwide online. Following her PhD in King's College London in Applied Microbiology and subsequent Post Doctoral position at Glaxosmithkline she embarked on a quest of finding the optimal approach to health. She has found the Homeopathic approach to be most complete, bringing real and lasting health benefits as it focuses on the cause of disease, rather than just the superficial removal or suppression of symptoms. She loves homeopathy, because it focuses on the study of Nature! Given her academic background, she thoroughly enjoyed embarking on the most incredible learning journey; the healing secrets of the energetic contents of every substance on this planet, everything is a clue, every substance can be curative. There is the structure initiated by the mineral Kingdom, the sensitivity of plants in the Vegetal Kingdom, the competitiveness of the animal Kingdom and the liberation of stuck, deep miasmic states that the nosodes allow. Since she was a child, she always loved children and animals (particularly horses and dogs). Whilst living in Greece became involved with many rescue operations and as a horse lover and rider my interest fell particularly on horses, dogs, amongst other animals. Children's health is one of the most concerning aspects of parenthood. Although homeopathy works well in variety of diseases, it has special affinity for childhood problems. With over a decade of experience working with paediatricians and veterinarians she still finds remarkable to see how people and creatures respond to this wonderful system of medicine Website: https://alexcmelo.com/ Facebook group Farm Animals and Homeopathy: https://www.facebook.com/groups/farmanimalsandhomeopathy Ebook on Homeopathic Aid for Horse Owners and Riders: Homeopathic Aid for Horse Owners & Riders Profile on Homeopathy 24/7: Dr. Alexandra Melo | Practicing Classical Homeopath If you would like to support the Homeopathy Hangout Podcast, please consider making a donation by visiting www.EugenieKruger.com and click the DONATE button at the top of the site. Every donation about $10 will receive a shout-out on a future episode.
Melvyn Bragg and guests discuss the most abundant lifeform on Earth: the viruses that 'eat' bacteria. Early in the 20th century, scientists noticed that something in their Petri dishes was making bacteria disappear and they called these bacteriophages, things that eat bacteria. From studying these phages, it soon became clear that they offered countless real or potential benefits for understanding our world, from the tracking of diseases to helping unlock the secrets of DNA to treatments for long term bacterial infections. With further research, they could be an answer to the growing problem of antibiotic resistance.With Martha Clokie Director for the Centre for Phage Research and Professor of Microbiology at the University of LeicesterJames Ebdon Professor of Environmental Microbiology at the University of BrightonAnd Claas Kirchhelle Historian and Chargé de Recherche at the French National Institute of Health and Medical Research's CERMES3 Unit in Paris.Producer: Simon TillotsonIn Our Time is a BBC Studios Audio ProductionReading list: James Ebdon, ‘Tackling sources of contamination in water: The age of phage' (Microbiologist, Society for Applied Microbiology, Vol 20.1, 2022) Thomas Häusler, Viruses vs. Superbugs: A Solution to the Antibiotics Crisis? (Palgrave Macmillan, 2006)Tom Ireland, The Good Virus: The Untold Story of Phages: The Mysterious Microbes that Rule Our World, Shape Our Health and Can Save Our Future (Hodder Press, 2024)Claas Kirchhelle and Charlotte Kirchhelle, ‘Northern Normal–Laboratory Networks, Microbial Culture Collections, and Taxonomies of Power (1939-2000)' (SocArXiv Papers, 2024) Dmitriy Myelnikov, ‘An alternative cure: the adoption and survival of bacteriophage therapy in the USSR, 1922–1955' (Journal of the History of Medicine and Allied Sciences 73, no. 4, 2018)Forest Rohwer, Merry Youle, Heather Maughan and Nao Hisakawa, Life in our Phage World: A Centennial Field Guide to Earth's most Diverse Inhabitants (Wholon, 2014)Steffanie Strathdee and Thomas Patterson (2019) The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug: A Memoir (Hachette Books, 2020)William C. Summers, Félix d`Herelle and the Origins of Molecular Biology (Yale University Press, 1999)William C. Summers, The American Phage Group: Founders of Molecular Biology (University Press, 2023)
In this episode, Brewmaster Dan Carey invited retired brewing scientist and microbiologist Greg Casey on the podcast to discuss all things lager beer. Greg Casey has a PhD in Applied Microbiology & Food Science from the University of Saskatchewan and worked for Anheuser-Busch (1987-1991), Red Star Yeast and Products (1991-1992), The Stroh Brewery Company (1992-1999) and Coors/Molson Coors/MillerCoors (1999-2013). Greg has written a series of books titled The Inspiring History and Legacies of American Lager Beer covering the history of lager beer in America. The first of which will be published later this spring. Cheers!
A teoria dos germes coloca que certas doenças são causadas pela invasão do corpo por microorganismos (organismos muito pequenos para serem vistos, exceto através de um microscópio). Separe meia horinha do seu dia e descubra com a Dra. Mila Massuda (@milamassuda) do BlaBlaLogia (@blablalogia) como a pesquisa se desenvolveu para a descoberta dos microrganismos e a sua associação com algumas doenças. Apresentação: Mila Massuda (@milamassuda) Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia) Edição: @Matheus_Heredia (@mewmediaLAB) Produção Prof. Vítor Soares (@profvitorsoares) e BláBláLogia (@blablalogia) REFERÊNCIAS: CROFT, William J. Under the microscope: a brief history of microscopy. World Scientific, 2006. FARRELL, Elliston. SYMPOSIUM ON TROPICAL MEDICINE III. MALARIA. Bulletin of the Medical Library Association, v. 30, n. 4, p. 345, 1942. FERREIRA, Luiz Alberto Peregrino et al. Girolamo Fracastoro and the Origin of the Etymology of Syphilis. Advances in Historical Studies, v. 6, n. 03, p. 104, 2017. GRADLE, Henry. The Germ Theory of Disease." Popular Sci, 1883. MANCINI, Renata; NIGRO, Mario; IPPOLITO, Giuseppe. Lazzaro Spallanzani and his refutation of the theory of spontaneous generation. Le Infezioni in Medicina, v. 15, n. 3, p. 199-206, 2007. MÜNCH, Ragnhild. Robert Koch. Microbes and Infection, v. 5, n. 1, p. 69-74, 2003. PASTEUR, Louis; FAULKNER, Frank. Studies on fermentation: the diseases of beer, their causes, and the means of preventing them. Kraus Reprint, 1879. SCHWARTZ, Maxime. The life and works of Louis Pasteur. Journal of Applied Microbiology, v. 91, n. 4, p. 597-601, 2001. TULCHINSKY, Theodore H. John Snow, cholera, the broad street pump; waterborne diseases then and now. Case studies in public health, p. 77, 2018.
As a high school student growing up in Melfort, Sask.. Linda Chelico knew she wanted to work in health sciences. She enjoyed biology class, and took an interest in watching nature heal itself. She wanted to find environmentally friendly solutions to health problems. Then, she read a National Geographic magazine about landfills filling up. Chelico began thinking about the environmental footprint of garbage, and about the organisms that could help break down piles of refuse. The idea turned into her Grade 11 science project, where she showed ways micro-organisms could degrade some of the waste people produce. “That's when I decided I wanted to be a microbiologist,” said Chelico. Watching evolving life forms had her hooked. She moved a two-hour drive west to Saskatoon, and enrolled as a microbiology student at the University of Saskatchewan. Within a year, she switched to an honours degree through the College of Agriculture's Applied Microbiology program. She earned her PhD in Saskatoon studying insecticidal fungal strains, with varied results. “You could kill the insects without putting chemicals in the environment,” said Chelico. As she tested the fungus on arid prairie fields, the effects of its prolonged exposure to sunlight and irradiation intrigued her. “Some of these fungal spores would survive a lot of UV damage,” she said. “It would dry out, it would acquire mutations. And I was trying to formulate it with sunscreens and then in the lab irradiate it with UV radiation, like if you're going to a tanning bed.” Although mutations were generally seen as negative for cell health in her course work, Chelico realized they deserved a closer look. “There's extreme stress on the organisms. They've acquired a lot of DNA damage from this UV irradiation,” she said. “So how do they survive?” In this episode, we hear how Chelico's interest in damaged, mutant cells morphed into a scientific Hollywood story, after she met Myron F. Goodman, at the University of Southern California's Los Angeles laboratories. Chelico spent five years of post-doctoral work studying microcellular activity and biological responses to stress in Goodman's lab. “Everything was unified by the benefit of mutations,” she said. By 2009, Chelico put Hollywood Boulevard in the rear-view mirror, returning to Saskatoon to accept a faculty position at the University of Saskatchewan's College of Medicine. Working as a virologist, microbiologist and biochemist, Chelico and her teams have landed more than $1.6 million dollars in three years, with continuing grants from the Canadian Institutes of Health Information. Her laboratory is focused on what key enzyme mutations in viruses mean, particularly for patients with HIV-AIDS, other viruses, and cancer. “In humans, when these mutations happen, usually we see it come out as a cancer,” said Chelico. “It doesn't exist in all of our cells. It exists in the type of [immune] cells that react to environmental stress.”
It's great to find a helpful learning resource. Here, I chat to the author of the book "Bacterial Genetics and Genomics", Prof Lori Snyder about the book, who it will be useful for and why this resource is different from others. About our Guest: Prof. Lori A. S. Snyder is a Professor in the School of Life Sciences, Pharmacy, and Chemistry at Kingston University, where she is involved in educating undergraduate and graduate students, as well as leading an active and collaborative research group. Prof. Snyder is also active in science outreach activities, including traveling lab visits, offering work experience to teenagers, and participating in public engagement events. Her research focuses on two main areas: combating antibiotic resistant infections and bacterial genetics and genomics. Her novel antimicrobials to stop infant blindness from multi-drug resistant bacterial infections have been featured in Wired (www.wired.co.uk/article/fight-against-super-gonorrhoea) and on the Sparks children's charity YouTube channel (https://www.youtube.com/watch?v=rQUl5-kC1OQ). Her use of bacterial genome sequence data to uncover new information about pathogens was featured in an interview on the Thermo Fisher Scientific YouTube channel about use of their sequencing system (https://www.youtube.com/watch?v=Z_ttuJ6l1hI&t=95s) and in 2013 her contributions were recognized by the Society for Applied Microbiology with the W H Pierce Prize (https://sfam.org.uk/resource/wh-pierce-2013-lori-snyder.html). Prof. Snyder was twice elected to the Prokaryotic Division committee of the Microbiology Society and services on the Editorial Board of its journal Microbial Genomics, as well as contributing by reviewing many research publications and grant applications.Find Prof Lori Snyder at: Twitter: @DrLoriSnyderSenior Editor: @CrumlyChuckPublisher: @CRCPressBook: https://www.routledge.com/Bacterial-Genetics-and Genomics/Snyder/p/book/9780815345695Book – missing content https://s3-eu-west-1.amazonaws.com/s3-euw1-ap-pe-ws4-cws-documents.ri-prod/9780815345695/9780815345695_missing_content.pdfBook - support materials https://routledgetextbooks.com/textbooks/9780815345695/Find Microbe Mail at: Visit the Microbe Mail website to sign up for updates E-mail: mail.microbe@gmail.comTwitter: @microbemail Instagram: Microbe_Mail
Alexandra C. Melo (PhD) is a Homeopath and Microbiologist (PhD) practicing in London and worldwide online. Following her PhD in King's College London in Applied Microbiology and subsequent Post Doctoral position at Glaxosmithkline she embarked on a quest of finding the optimal approach to health. She has found the Homeopathic approach to be most complete, bringing real and lasting health benefits as it focuses on the cause of disease, rather than just the superficial removal or suppression of symptoms. She loves homeopathy, because it focuses on the study of Nature! Given her academic background, she thoroughly enjoyed embarking on the most incredible learning journey; the healing secrets of the energetic contents of every substance on this planet, everything is a clue, every substance can be curative. There is the structure initiated by the mineral Kingdom, the sensitivity of plants in the Vegetal Kingdom, the competitiveness of the animal Kingdom and the liberation of stuck, deep miasmic states that the nosodes allow. Since she was a child, she always loved children and animals (particularly horses and dogs). Whilst living in Greece became involved with many rescue operations and as a horse lover and rider my interest fell particularly on horses, dogs, amongst other animals. Children's health is one of the most concerning aspects of parenthood. Although homeopathy works well in variety of diseases, it has special affinity for childhood problems. With over a decade of experience working with paediatricians and veterinarians she still finds remarkable to see how people and creatures respond to this wonderful system of medicine Website: https://alexcmelo.com/ Facebook group Farm Animals and Homeopathy: Farm Animals and Homeopathy | Facebook Ebook on Homeopathic Aid for Horse Owners and Riders: Homeopathic Aid for Horse Owners & Riders Profile on Homeopathy 24/7: Dr. Alexandra Melo | Practicing Classical Homeopath Link to youtube: A Journey to Homeopathy: Dr. Alexandra Melo
Uma pesquisa publicada no Jornal de Microbiologia Aplicada (Journal of Applied Microbiology, nome da publicação científica em inglês) demonstrou que lavar louças com esponja pode ser um risco à saúde. Segundo os pesquisadores, as esponjas têm estruturas internas muito grandes às quais as bactérias podem se ligar, além de áreas abertas onde os fluidos com resíduos de alimentos podem se acumular, o que pode favorecer o crescimento dos microrganismos. Algumas dessas bactérias resistem ao enxágue normal em água corrente ou com sabão. Por isso, nesta edição do CBN na Sua Casa, Lucy Mizael dá dicas de como minimizar esse risco. Acompanhe!
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. Resources: Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice [16] Is Turmeric Good for Your Heart? Here's What the Science Shows [17] 10 Surprising Ways Turmeric Benefits a Woman's Health
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. Resources: Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice [16] Is Turmeric Good for Your Heart? Here's What the Science Shows [17] 10 Surprising Ways Turmeric Benefits a Woman's Health
When you're in a public restroom, do you go for the paper towels or the air dryer after you wash your hands? To get your hands cleanest, choose the towels. A study in the Journal of Applied Microbiology put each drying method to the test and revealed that rubbing hands thoroughly dry with paper towels may give people the best chance of walking out of the restroom with germ-free mitts. The researchers found that no matter which method you choose, you won't be rid of germs unless you dry your hands thoroughly. Germs love water. It's their ideal medium for multiplying and getting around. Putting in the time and effort to really dry hands completely will mean way fewer germs. And drying hands vigorously with a paper towel bested rubbing them dry under a blower when it came to germ levels. It seems the skin-on-skin friction created when we rub our hands under the blower somehow releases more germs that live deep in our pores. If you want to use the blower because it
Since the main part of this podcast is about a short five mile walk we thought this would be a shorter episode than normal. But how wrong we were. We still managed to blather on for what seemed like hours! We kick off with some concerning news about some unedifying scenes in the Facebook Group today with a discussion about Paul's bottom. This is a family show and we've no idea what prompted such a debate. Much!! Despite eye watering petrol and diesel prices we've managed to get out a little in the last two weeks. Glyn had a weekend in Wells but that's in Somerset so we're not interested! But he did see the sad spectacle of the broken spire of St Thomas' Church, blown down during Storm Eunice like a scene from Hot Fuzz, also filmed in Wells. Meanwhile Paul had a reminder of how grim London is, but since that's not in Wiltshire we're not interested in that either. But Paul did manage to do a day long walk based in the hills around Aldbourne, visiting the site of the abandoned village of Snap on the way. We're grateful to Andrew Rumsey, Bishop of Ramsbury, for helping us find it. There's a link to his fantastic book, English Grounds, below. Paul posted a blog with lots of photographs of the walk on 9 March. There's a link to it below. We'll do a podcast about it sometime. Another recent blog posted on the website was one about the Russian scientist Vladimir Artemovich Pasechnik who defected in the 1980s and moved to Shrewton. He worked at the UK Department of Health's Centre for Applied Microbiology & Research (CAMR) at Porton Down and went on to do some ground breaking research into tuberculosis and other drug resistant infections. He is buried in one of the churchyards in the village. You'll find a link to the blog below. Otherwise, Glyn has been playing with his new toy, a 360 degree camera which he's managed to hook up to our outside recording equipment. Watch out for content produced with this gear in the future. If it ever stops raining. Meanwhile Paul has walked a few of his regular routes onto Salisbury Plain. The current extensive Army training exercises and the heavy armour have made a dreadful mess of the sodden ground on the Plains. But nearby the haven that is Parsonage Down is beginning to show the first signs of Spring and there's been some interesting research taking place about the impact of grazing on the flora there. Our main subject this week is the walk that Paul and his walking buddy Stu did in November 2021 which was the subject of a Blog dated 26 November entitled Medieval Inglesham – Three Counties Walk. Continuing this episode's theme of straying beyond Wiltshire this walk in the extreme north-east of the county involved brief forays into neighbouring Gloucestershire and Oxfordshire. But this was necessary in order to reach our objective. This part of Wiltshire forms a finger shaped wedge into Gloucestershire and Oxfordshire. But we began the walk in Lechlade-on-Thames in Gloucestershire, and very nearly got no further than the splendid Sourdough Revolution artisan bakery and café. We could quite happily have stayed there all morning! But we were on a mission so we re-crossed Halfpenny Bridge and followed the south side of the Thames, safely back in Wiltshire, en-route to our objective – the Church of St John the Baptist at Inglesham via a thoroughly ugly lock-keepers cottage that looked like a concrete cooling tower on the way. We were concerned the church might be locked but were relieved to find it open. And oh my, what a sight awaited us as we opened first one door then another. We'll leave you to read the blog and look at the photographs but suffice to say this spectacular and unique little church was thoroughly worth the trip. And of course, having forgotten what he'd had for breakfast this morning, Paul managed to also forget that he'd posted something on the Hidden Wiltshire Facebook page about a feature on Channel 5 about the church where Tony Robinson interviewed our favourite stonemason Andrew Ziminksi. It was broadcast on 8 October 2021. From the church the walk took us to Buscot Weir via Buscot Wick before returning to Lechlade via the Thames path, criss-crossing counties as we went. We passed by the impressive Buscot Old Parsonage where American voices were to be heard. In the podcast Paul said he didn't know who owned it after its previous owner, art collector Peter Francis Carew Stucley, died in 1964. Subsequent reading revealed it is now owned by the National Trust who also own nearby Buscot Park. Stucley's will stated that the property should be rented furnished to American citizens actively pursuing literary, artistic or academic studies. And it clearly is to this day. In all the walk was a flat and easy five miles, although at this time of year it may be boggy in places. Then on to the wrap up: Steve Dixon's piece leading into our main subject today is called “Fragile” because it sounds as though it was performed on a church organ! As ever the piece in the introduction and at the end of the podcast is entitled “The Holloway”. Don't forget to check out the Hidden Wiltshire online shop on the website if you'd like to help us keep the lights on. Both Hidden Wiltshire books can be purchased there. The second book is also available at Devizes Bookshop, Wiltshire Museum in Devizes and now Wiltshire's libraries. And don't forget to subscribe to the Hidden Wiltshire Newsletter from the website. You can also subscribe to alerts about new Blogs. Links: Andrew Rumsey's beautiful book, English Grounds – A Pastoral Journey, can be found here English Grounds and at other booksellers of course. The Blog about the Aldbourne Circular Route can be found here Aldbourne Circular Route The Blog about the Russian exile to Wiltshire Vladimir Artemovich Pasechnik can be found here Vladimir Artemovich Pasechnik You can follow the walk in this episode of the podcast here Medieval Inglesham - Three Counties Walk Glyn's photographs can be seen on his Instagram feed @coy_cloud He is also very active on Twitter where his username is @Glyndle Paul's photography can be found on his website at Paul Timlett Photography and on Instagram at @tragicyclist Steve Dixon's sound art can be found on Soundcloud where his username is River and Rail Steve Dixon River and Rail. His photographs can be found on Instagram at @stevedixon_creative and his graphic design business website is at Steve Dixon Creative And finally you'll find the Hidden Wiltshire online shop here Hidden Wiltshire Shop and a link to Glyn's blog about the latest book and how to purchase a copy here Hidden Wiltshire from near and far
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. Resources: Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice [16] Is Turmeric Good for Your Heart? Here's What the Science Shows [17] 10 Surprising Ways Turmeric Benefits a Woman's Health
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. Resources: Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice [16] Is Turmeric Good for Your Heart? Here's What the Science Shows [17] 10 Surprising Ways Turmeric Benefits a Woman's Health
Original Transplants Episode 64: Supply Chain Resilience Original Transplants Podcast Episode 64: Supply Chain Resilience finds Satoyama Homestead stewards Will and Sarah planning for the year ahead in 2022 in the bee yard, chicken coop, and edible landscape. Will is researching spring bee package suppliers following the demise of his beehives, with one colony absconding and the other dead-out. In better news, the four pullets he raised from chicks during the summer are fully integrated into the flock and have begun egg-laying. Sarah is slowly prepping the vegetable garden beds for the off-season and plans to identify some of the weeds to see if any are useful and should be saved during clean-up. The homesteaders are enjoying the previous season's harvest, including glazing a roast ham with kiwiberry preserves and using dehydrated vegetables on veggie pizza. Will explains harvesting vermicompost and leachate from the worm farm, and the homesteaders plan new storage methods to prevent clumping in key homemade soup ingredients borax and washing soda. Sarah looks forward to enjoying bird watching with Lucy and her birdseed bell from Santa, and is browsing seed catalogs to plan next year's vegetable garden. The homesteaders review new science about the discovery of microplastics in infants at ten times the rate in adults, and discuss agricultural news about how to evaluate your supply chain vulnerabilities and make your supply chain more resilient. Notes Infants have more microplastics in their feces than adults, study finds - American Chemical Society https://www.acs.org/content/acs/en/pressroom/newsreleases/2021/september/infants-have-more-microplastics-in-their-feces-than-adults-study-finds.html Microplastics revealed in the placentas of unborn babies - The Guardian https://www.theguardian.com/environment/2020/dec/22/microplastics-revealed-in-placentas-unborn-babies Vermicomposting for beginners - Rodale Institute https://rodaleinstitute.org/science/articles/vermicomposting-for-beginners/ Bacterial diversity in a finished compost and vermicompost: differences revealed by cultivation-independent analyses of PCR-amplified 16S rRNA genes - Applied Microbiology and Biotechnology via Academia.edu https://www.academia.edu/20157205/Bacterial_diversity_in_a_finished_compost_and_vermicompost_differences_revealed_by_cultivation_independent_analyses_of_PCR_amplified_16S_rRNA_genes Assessing the impact of composting and vermicomposting on bacterial community size and structure, and microbial functional diversity of an olive-mill waste - Bioresource Technology https://doi.org/10.1016/j.biortech.2008.08.014 What to do about hard clumpy borax and washing soda - The Make Your Own Zone https://www.themakeyourownzone.com/clumpy-hard-borax-washing-soda/ How vulnerable is your personal supply chain? - Charles Hugh Smith, Of Two Minds Blog https://www.oftwominds.com/blogdec21/personal-supply-chain12-21.html
When you're in a public restroom, do you go for the paper towels or the air dryer after you wash your hands? To get your hands cleanest, choose the towels. A study in the Journal of Applied Microbiology put each drying method to the test and revealed that rubbing hands thoroughly dry with paper towels may give people the best chance of walking out of the restroom with germ-free mitts. The researchers found that no matter which method you choose, you won't be rid of germs unless you dry your hands thoroughly. Germs love water. It's their ideal medium for multiplying and getting around. Putting in the time and effort to really dry hands completely will mean way fewer germs. And drying hands vigorously with a paper towel bested rubbing them dry under a blower when it came to germ levels. It seems the skin-on-skin friction created when we rub our hands under the blower somehow releases more germs that live deep in our pores. If you want to use the blower because it
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. DEEP DIVE RESOURCES Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice
You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? Tune in to today's episode to unlock the magic of turmeric! Turmeric and Black Pepper: The Best Way to Take Turmeric? You've likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric's bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric's many health-supportive properties are attributed to curcumin, a key component of turmeric that's associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It's also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric's bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn't Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn't to say that black pepper is inherently dangerous, and there's no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There's also evidence to show that taking curcumin along with just piperine, black pepper's primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there's always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric's full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here's another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person's digestive system, black pepper is known to interfere with a process known as glucuronidation that's necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there's little-to-no risk of these types of complications. That's because there's nothing like black pepper getting in the way to block the body's important detoxification pathways. It's rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb's active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric's absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver's functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what's found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it's time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn't gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. DEEP DIVE RESOURCES Turmeric 3D by Organixx ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 The BIG 3 Anti-Inflammatories – Episode 88 [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice
Have you ever been curious about microbiome, nutrition and health? Have you heard many discuss nutrition, microbiome and weight loss but not sure how to separate the facts from myth? If you answered yes to any of these questions, this episode is one you do not want to want to miss. Our special guest is Dr. Liping Zhao, who is a leading scientist recognized around the world for his groundbreaking work in the field of microbiome. He is chair of Applied Microbiology at the dept of Biochemistry and Microbiology at Rutgers University. He is also the Director of the Center for Nutrition, Microbiome and health at the New Jersey Institute of Food, Nutrition and Health, At Rutgers University. He is a fellow of the American Academy of Microbiology and a Senior Fellow of the Canadian Institute for Advanced Research (CIFAR). He serves on Scientific Advisory Board for the Center for Microbiome Research and Education of the American Gastroenterology Association. (https://dbm.rutgers.edu/websites/liping-zhao/) Resources Learn more about food and health, connect with innovators & experts: https://gfhisummit.com Help your children understand the importance of food to health, download free activity sheets here: https://foodniche-ed.com/resources Do you work with a food brand or own one? Explore ways to promote your brand and expand your network here: https://foodnicher.com Bookmark this page and watch for 2022: https://grubeasy.io/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
If you're like me, you have lots of visitors tracking in and out of your house during the summer months. Outside of asking them to take off their shoes like I talked about in the EMM episode for February, something else I've educated my house guests on is making sure they shut that lid! Have you ever thought about why toilets have lids in the first place? No, it's not just for keeping the dog from drinking the toilet water…though after listening today, you'll want to do that too. The lids are there to keep the germs inside the bowl and prevent them from getting on your toothbrush and your other bathroom supplies. Myth Busters did an episode several years back in which they investigated the aerosol effect of toilets. There have actually been several published studies looking at this effect and just how far it can carry, along with WHAT exactly it carries. Spoiler alert: there could be Covid-laden bacteria in your toilet bowl! Listen in on this mini segment of the podcast for why you need to put the lid down, please! Links from the show: Cloth Diaper Podcast Interview w/ Aisha: https://www.clothdiaperpodcast.com/show-54/ (https://www.clothdiaperpodcast.com/show-54/) Discovery Channel Video: https://www.youtube.com/watch?v=TrrbdSqhLNM (https://www.youtube.com/watch?v=TrrbdSqhLNM) Journal of Applied Microbiology: https://pubmed.ncbi.nlm.nih.gov/16033465/ (https://pubmed.ncbi.nlm.nih.gov/16033465/) ABC News Article: https://abcnews.go.com/Health/closing-lid-flush-lessen-spreading-coronavirus-forget-panic/story?id=71383765 (https://abcnews.go.com/Health/closing-lid-flush-lessen-spreading-coronavirus-forget-panic/story?id=71383765) Nat Geo Article: https://abcnews.go.com/Health/closing-lid-flush-lessen-spreading-coronavirus-forget-panic/story?id=71383765 (https://abcnews.go.com/Health/closing-lid-flush-lessen-spreading-coronavirus-forget-panic/story?id=71383765) Connect with Mackenzie: Instagram: @theheartfelthippie // @the.enlightenme.podcast Facebook: https://www.facebook.com/theheartfelthippie/ (https://www.facebook.com/theheartfelthippie/) Website: http://www.heartfelthippie.com (www.heartfelthippie.com) Email: mackenzie.heartfelthippie@gmail.com
Turmeric and Black Pepper: The Best Way to Take Turmeric? You’ve likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric’s bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric’s many health-supportive properties are attributed to curcumin, a key component of turmeric that’s associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It’s also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric’s bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn’t Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn’t to say that black pepper is inherently dangerous, and there’s no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There’s also evidence to show that taking curcumin along with just piperine, black pepper’s primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there’s always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric’s full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here’s another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person’s digestive system, black pepper is known to interfere with a process known as glucuronidation that’s necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there’s little-to-no risk of these types of complications. That’s because there’s nothing like black pepper getting in the way to block the body’s important detoxification pathways. It’s rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb’s active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric’s absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver’s functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what’s found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it’s time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn’t gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. DEEP DIVE RESOURCES Turmeric 3D by Organixx https://shop.organixx.com/a/secure/checkout/OobbS9ROAoETfnAGmGDF?ch-tn-box=first-box&gl=5d8908c502e26b5f0c38083c ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 https://organixx.com/empowering-you-organically/paractin-potent-form-of-andrographis-paniculata-for-pain-support/ The BIG 3 Anti-Inflammatories – Episode 88 https://organixx.com/empowering-you-organically/the-big-3-anti-inflammatories/ [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice Subscribe to Empowering You Organically Never miss an episode! APPLE PODCASTS SPOTIFY GOOGLE PODCASTS
Turmeric and Black Pepper: The Best Way to Take Turmeric? You’ve likely heard about the many health benefits of turmeric (Curcuma longa L.) and its compound curcumin. But did you know that it can be difficult to “unlock” the nutrients in turmeric so your body can actually take full advantage of them? One popular way to make the compounds in turmeric more bioavailable (absorbable and usable to the body) is to pair it with another popular cooking spice: black pepper [1]. But what if there was a better way than combining turmeric and black pepper? A way to boost turmeric’s bioavailability, allowing it to more safely and effectively support the natural healing process? The Healing Power of Turmeric Turmeric is a staple remedy from the traditional medicine systems of the Far East that has gained widespread popularity throughout the West in recent years as a “super” spice. Turmeric’s many health-supportive properties are attributed to curcumin, a key component of turmeric that’s associated with longevity. Curcumin is documented in the scientific literature as offering powerful support for the cardiovascular, neurological, metabolic, immune, and cellular systems. It’s also the part of turmeric that gives this root spice its rich, golden yellow color. But the truth of the matter is that humans have a difficult time getting all the health benefits from turmeric when consuming the spice all by itself. Research shows that only a very small portion of it is assimilated into the body when eaten in isolation. This is why many natural health experts suggest consuming turmeric along with black pepper (Piper nigrum). Black pepper contains a unique “bio-enhancer” compound known as piperine that significantly boosts turmeric’s bioavailability – by as much as 2,000 percent, in fact. This is the reason why many turmeric and curcumin supplement products on the market today contain either black pepper or piperine. The Problem: Black Pepper Isn’t Good for Everyone This pairing approach of turmeric and black pepper comes with limitations, however, as too much black pepper can actually be detrimental to health – especially in people with gastrointestinal issues.Research published in the American Journal of Gastroenterology found that consuming black pepper in excess can damage the mucosal lining of the gut, potentially causing bleeding or other injuries. Consuming high amounts of black pepper, this same study found, is akin to taking the painkiller drug aspirin [2]. In other words, aspirin represents a similar threat to the gut lining in terms of its tendency to cause serious erosions and ulcers in the intestinal tract [3]. This isn’t to say that black pepper is inherently dangerous, and there’s no need to toss out the pepper shaker just yet. After all, the amounts of black pepper required to induce such harm are far greater than what the average person consumes in their food on a daily basis. There’s also evidence to show that taking curcumin along with just piperine, black pepper’s primary alkaloid, is typically safe and causes “no adverse effects [4].” Even so, there’s always the possibility that someone might react negatively to this combination – especially when taking very high doses of turmeric or curcumin for therapeutic purposes. For this reason, science set out to determine whether or not it was possible to retain turmeric’s full bioavailability without the need for black pepper, piperine, or any other additive. And the good news is, it is possible. Fermentation Increases the Power of Turmeric BETTER Than Black Pepper As it turns out, by fermenting turmeric its active constituents can be drawn out and made more potent in a way similar to, and potentially even greater than, black pepper. Here’s another reason why fermented turmeric may be superior to turmeric and black pepper. Besides possibly upsetting a person’s digestive system, black pepper is known to interfere with a process known as glucuronidation that’s necessary for eliminating toxins from the body [5]. Put simply, too much black pepper can cause a buildup of xenoestrogens (harmful chemicals found in plastic and other everyday products) and other toxins that would otherwise be quickly eliminated from the body [6]. With simple fermentation, however, there’s little-to-no risk of these types of complications. That’s because there’s nothing like black pepper getting in the way to block the body’s important detoxification pathways. It’s rather like eating fresh turmeric, which still contains all of the volatile (essential) oils that help to deliver the herb’s active compounds throughout the body. Fermentation may even go a step beyond this by further optimizing turmeric’s absorption potential. Research conducted on rat models found that fermented turmeric is, indeed, the best form of turmeric because it contains the most antioxidant power. Compared to ground turmeric in powder and probiotic forms, fermented turmeric led to substantially higher plasma antioxidant concentrations in test subjects [7]. In terms of how it affects the liver, fermented turmeric was shown in a paper out of South Korea to be powerfully hepatoprotective, meaning it shields the liver from damage. Not only that, but fermented turmeric was also shown to help improve the liver’s functional detoxification potential [8] – as opposed to black pepper-potentiated turmeric that can inhibit natural detoxification. Fermented turmeric also contains more curcumin (the beneficial compound) than unfermented turmeric, by volume. In addition to improving both its antioxidant and antimicrobial capacity, fermenting turmeric draws out an impressive 11% more curcumin compared to what’s found in raw turmeric. Fermentation also makes turmeric 3.1 times more effective at scavenging oxidizing free radicals from the body [9]. Another area where fermented turmeric has a leg up on both unfermented turmeric and turmeric combined with black pepper is in the area of inflammation. Research published by The Korean Society for Applied Microbiology and Biotechnology found that fermented turmeric is a powerful anti-inflammatory, possessing the ability to inhibit pro-inflammatory cytokines much more effectively than any other known form of turmeric. Fermented turmeric was further shown in this same study to protect against acute anaphylactic, or allergic, reactions [10]. From an antimicrobial perspective, fermented turmeric shows incredible potential against a wide variety of pathogenic bacteria, including drug-resistant “superbugs.” Research out of the Middle East found that fermented turmeric provides broad-spectrum protection against harmful bacteria such as Escherichia coli (E. coli), Streptococcus agalactiae, Staphylococcus aureus (Staph), Entreococcus faecalis, Methicillin-Resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Pseudomonas aeruginosae [11]. Research out of China found that fermented curcumin can be a powerful weapon against high cholesterol, also known as hyperlipidemia. While unfermented curcumin showed minimal-to-no benefits during the evaluation, its fermented counterpart significantly reduced serum lipid levels in test models [12]. Fermented Turmeric Increased Fat Loss in Animal Test Subjects Fermented turmeric also shows promise in fighting another undesirable form of fat: the obesity kind. Research out of South Korea found that consumption of fermented turmeric can alter the expression of certain genes involved with lipid accumulation, effectively preventing them from communicating to the body that it’s time to pack on extra pounds [13]. Related research published a year later, also out of South Korea, reiterated these findings while building upon them. Obese rats fed a high-fat diet not only didn’t gain more weight when also consuming fermented turmeric, but they further lost weight as a result of consuming the herb as part of their daily eating routines [14]. Preventing Impairment of Learning and Memory Research has shown there are brain benefits associated with fermented turmeric as well. Among the findings fleshed out in a paper published in the journal BMC Complementary and Alternative Medicine was evidence suggesting that fermented turmeric has the potential to mitigate memory impairment while supporting optimized learning and memory ability in mice [15]. While more research needs to be done, the evidence so far seems clear… fermentation is the key to “unlocking” the incredible healing potential of turmeric, while avoiding the potential side effects of combining turmeric and black pepper. DEEP DIVE RESOURCES Turmeric 3D by Organixx https://shop.organixx.com/a/secure/checkout/OobbS9ROAoETfnAGmGDF?ch-tn-box=first-box&gl=5d8908c502e26b5f0c38083c ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More – Episode 87 https://organixx.com/empowering-you-organically/paractin-potent-form-of-andrographis-paniculata-for-pain-support/ The BIG 3 Anti-Inflammatories – Episode 88 https://organixx.com/empowering-you-organically/the-big-3-anti-inflammatories/ [1] Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. [2] Effect of red pepper and black pepper on the stomach. [3] The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers [4] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. [5] Turmeric, Hold the Black Pepper Please! [6] Glucuronidation [7] Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats [8] The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study [9] Antioxidant and Antimicrobial Effects of Fermented Tumeric (Curcuma longa L.) [10] Antiinflammatory and Antiallergic Activity of Fermented Turmeric by Lactobacillus [11] Influence of solid state fermentation by Trichoderma spp. on solubility, phenolic content, antioxidant, and antimicrobial activities of commercial turmeric. [12] Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus. [13] Evaluation of the Anti-obesity Activity of Platycodon grandiflorum Root and Curcuma longa Root Fermented with Aspergillus oryzae [14] Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. [15] The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice Subscribe to Empowering You Organically Never miss an episode! APPLE PODCASTS SPOTIFY GOOGLE PODCASTS
Learn about why you’re happier before achieving a goal than you are after; why horsepower probably doesn’t mean what you think it means; and how to keep your skin safe from the potentially harmful bacteria in your makeup bag. In this podcast, Cody Gough and Ashley Hamer discuss the following stories from Curiosity.com to help you get smarter and learn something new in just a few minutes: Here's Why You're Happier Before Achieving a Goal Than You Are After — https://curiosity.com/topics/heres-why-youre-happier-before-achieving-a-goal-than-you-are-after-curiosity Horsepower Doesn't Mean What You Think It Means — https://curiosity.com/topics/horsepower-doesnt-mean-what-you-think-it-means-curiosity Additional sources: Revealed: The deadly superbugs lurking in more than 9 in 10 make-up bags | EurekAlert! — https://www.eurekalert.org/pub_releases/2019-12/au-rtd120219.php Microbiological study of used cosmetic products: highlighting possible impact on consumer health | Society for Applied Microbiology — https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jam.14479 What You Really Need to Know About Makeup Expiration Dates | Byrdie — https://www.byrdie.com/makeup-expiration-dates-mascara-foundation-lipstick Amazon smart speaker users: you can listen to our podcast as part of your Amazon Alexa Flash Briefing! Just click or tap “enable” here: https://curiosity.im/podcast-flash-briefing.
¡Por fin la segunda parte de la historia del inicio de las vacunas! Pasteur, peleas entre científicos, polvo de médula, rabia en niños y mucho más en este nuevo episodio. Louis Pasteur y todo su aporte al mundo de las vacunas. ¡No se lo pueden perder! BibliografíaAleem, M. A. (2015). Louis Pasteur (1822 - 1895). Journal of The Associations of Physicians of India, 63, 621314. Guo, S. (2015). Biography of Professor Louis Pasteur. Journal of Applied Virology, 4(2), 2305–2307. Pettinger, T. (2008). Louis Pasteur Biography. Retrieved from www.biographyonline.net Plotkin, S. (2011). History of Vaccine Development. Plotkin, S. (2014). History of vaccination. Proceedings of the Natinal Academy of Sciences, 111(34), 12283–12287. https://doi.org/10.1073/pnas.1400472111 Schwartz, M. (2001). The life and works of Louis Pasteur. Journal of Applied Microbiology, (February), 597–601. Smith, K. A. (2012). Louis Pasteur , the father of immunology ? Frontiers in Immunology, 3(April), 1–10. https://doi.org/10.3389/fimmu.2012.00068 Tarrés, A., & X, A. (2013). Las vacunas en la historia , o una historia de las vacunas. Anales de Pediatría, 79(1), 1–2. https://doi.org/10.1016/j.anpedi.2013.02.010
When you're in a public restroom, do you go for the paper towels or the air dryer after you wash your hands? To get your hands cleanest, choose the towels. A study in the Journal of Applied Microbiology put each drying method to the test and revealed that rubbing hands thoroughly dry with paper towels may give people the best chance of walking out of the restroom with germ-free mitts. The researchers found that no matter which method you choose, you won't be rid of germs unless you dry your hands thoroughly. Germs love water. It's their ideal medium for multiplying and getting around. Putting in the time and effort to really dry hands completely will mean way fewer germs. And drying hands vigorously with a paper towel bested rubbing them dry under a blower when it came to germ levels. It seems the skin-on-skin friction created when we rub our hands under the blower somehow releases more germs that live deep in our pores. If you want to use the blower because it
Every society’s journey with Open Access (OA) is different. Hear from the Society for Applied Microbiology’s Executive Director about what happened when they decided to flip a struggling young journal to OA.
Vendedores deambulantes de costras, vacas salvando vidas, la medicina el anticristo y muchos temas más tratados en esta primera parte sobre la historia del inicio de las vacunas. La variolización y la contribución de Edward Jenner a la medicina en un solo episodio, ¡No se lo pueden perder! Bibliografía y música Aleem, M. A. (2015). Louis Pasteur (1822 - 1895). Journal of The Association of Physicians of India, 63, 621314. Artenstein, A., & Poland, G. (2012). Vaccine history : The past as prelude to the future. Vaccine, 30, 5299–5301. http://doi.org/10.1016/j.vaccine.2012.06.060 Baron, B. J. (1838). The Life Of Edward Jenner. Boylston, A. (2012). The origins of inoculation. Journal of the Royal Society of Medicine, 309–313. Edward Jenner: His Life, His Work and His Writings. (1896). British Medical Journal. González, D., González, M., Fomental, B., & Molina, M. (2007). La Variolación y el Advenimiento de la Vacuna Contra la Viruela. Revista Habanera de Ciencias Médicas, 6(2). Retrieved from http://www.redalyc.org/articulo.oa?id=180414014003 Gregorio, E. De, & Rappuoli, R. (2014). From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nature Publishing Group, (June). http://doi.org/10.1038/nri3694 Guo, S. (2015). Biography of Professor Louis Pasteur, 4(2), 2305–2307. Hilleman, M. R. (2000). Vaccines in historic evolution and perspective : a narrative of vaccine discoveries. Vaccine, 18, 1436–1447. Jenner, E. (1802). An Inquiry Into the Causes and Effects of the Variolae Vaccinae. Louis Pasteur Biography. (2008). Ma, P. H. (2000). Vaccines , coming of age after 200 years. Microbiology Reviews, 24, 9–20. Morgan, A. J., & Parker, S. (2007). Translational Mini-Review Series on Vaccines : The Edward Jenner Museum and the history of vaccination. Clinical and Experimental Immunology, 389–394. http://doi.org/10.1111/j.1365-2249.2006.03304.x Morgan, A. J., & Poland, G. A. (2011). The Jenner Society and the Edward Jenner Museum : Tributes to a physician-scientist. Vaccine, 29, D152–D154. http://doi.org/10.1016/j.vaccine.2011.08.128 Morgan, A. J., Poland, G. A., & Editor-in-chief, M. (2013). Edward Jenner and the discovery of vaccination—An appeal for the Edward Jenner Museum. Vaccine, 1–2. http://doi.org/10.1016/j.vaccine.2013.07.046 Plotkin, S. (2011). History of Vaccine Development. Plotkin, S. A. (2005). Six Revolutions in Vaccinology. The Pediatric Infectious Disease Journal, 24(1), 1–9. http://doi.org/10.1097/01.inf.0000148933.08301.02 Rusnock, A. A. (2016). Historical Context and the Roots of Jenner ’ s Discovery. Human Vaccines and Immunotherapeutics, 5515(April). http://doi.org/10.1080/21645515.2016.1158369 Schwartz, M. (2001). The life and works of Louis Pasteur. Journal of Applied Microbiology, (February), 597–601. Smith, K. A. (2011). Edward Jenner and the small pox vaccine. Frontiers in Immunology, 2(June), 1–6. http://doi.org/10.3389/fimmu.2011.00021 Smith, K. A. (2012). Louis Pasteur , the father of immunology ? Frontiers in Immunology, 3(April), 1–10. http://doi.org/10.3389/fimmu.2012.00068 http://www.itmonline.org/5organs/intro.htm https://www.youtube.com/watch?v=R_yZfyzikPw https://www.youtube.com/watch?v=20-F5XvHJOY https://www.youtube.com/watch?v=yAHgqDPfaLM&t=17s https://www.youtube.com/watch?v=F65xB5yEp50 https://www.youtube.com/watch?v=8dIHA5VcM4k&t=13s
In 1495, a mysterious and deadly plague struck the city of Naples. Over the next 500 years, the medical attempts to understand and treat this new disease -- syphilis -- would mold and shape medicine in surprising ways. In this episode, Tony Breu and I will perform an historical and physiological biography of syphilis, covering the development of germ theory, epic poetry, mercury saunas, intentionally infecting patients with malaria, magic bullets, and lots and lots of experiments on poor rabbits. This presentation was performed live at the American College of Physicians’ national meeting in Philadelphia on April 11, 2019. Sources (WARNING -- LONG LIST): Swain, K. ‘Extraordinarily arduous and fraught with danger’: syphilis, Salvarsan, and general paresis of the insane. Lancet Psychiatry 5, (2018). Kępa, M. et al. Analysis of mercury levels in historical bone material from syphilitic subjects – pilot studies (short report). Kępa Małgorzata 69, 367-377(11) (2012). Forrai, J. Syphilis - Recognition, Description and Diagnosis. (2011). doi:10.5772/24205 Parascandola, J. From mercury to miracle drugs: syphilis therapy over the centuries. Pharm Hist 51, 14–23 (2009). Eisler, C. Who Is Dürer’s ‘Syphilitic Man’? Perspect Biol Med 52, 48–60 (2009). Rothschild, B. M. History of Syphilis. Clin Infect Dis 40, 1454–1463 (2005). Schwartz, R. S. Paul Ehrlich’s Magic Bullets. New Engl J Medicine 350, 1079–1080 (2004). Fee, E. The wages of sin. Lancet 354, SIV61 (1999). O’Shea, J. ‘Two Minutes with Venus, Two Years with Mercury’-Mercury as an Antisyphilitic Chemotherapeutic Agent. J Roy Soc Med 83, 392–395 (1989). Mahoney, J., Arnold, R., Sterner, B. L., Harris, A. & Zwally, M. Penicillin Treatment of Early Syphilis: II. Jama 251, 2005–2010 (1984). Waugh, M. Role played by Italy in the history of syphilis. Sex Transm Infect 58, 92–95 (1982). Thorburn, A. Fritz Richard Schaudinn, 1871-1906: protozoologist of syphilis. Sex Transm Infect 47, 459–461 (1971). CROSBY, A. W. The Early History of Syphilis: A Reappraisal. Am Anthropol 71, 218–227 (1969). Clark, E. G. & Danbolt, N. The Oslo study of the natural history of untreated syphilis An epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material a review and appraisal. J Chron Dis 2, 311–344 (1955). MUNGER, R. S. Guaiacum, the Holy Wood from the New World. J Hist Med All Sci IV, 196–229 (1949). Thomas, E. & r, W. Rapid Treatment of Early Syphilis with Multiple Injections of Mapharsen. J Nerv Ment Dis 99, 88 (1944). WIEDER, L., FOERSTER, O. & FOERSTER, H. MAPHARSEN IN THE TREATMENT OF SYPHILIS: FURTHER EXPERIENCES. Arch Dermatol Syph 35, 402–413 (1937). THON, L. SHOULD THE INTERNIST KNOW SYPHILIS? J Amer Med Assoc 97, 994–996 (1931). Sarton, G. The Earliest Printed Literature on Syphilis, being Ten Tractates from the Years 1495-1498. Karl Sudhoff , Charles Singer , Henry E. Sigerist. Isis 8, 351–354 (1926). COLE, H., GERICKE, A. & SOLLMANN, T. THE TREATMENT OF SYPHILIS BY MERCURY INHALATIONS: HISTORY, METHOD AND RESULTS. Arch Dermatol Syph 5, 18–33 (1922). Mason, U. Observation: Use and Abuse of Salvarsan. J Natl Med Assoc 3, 340–3 (1911). Fleming, A. & Colebrook, L. ON THE USE OF SALVARSAN IN THE TREATMENT OF SYPHILIS. Lancet 177, 1631–1634 (1911). Evans, A. The Treatment of Syphilis by Salvarsan (Dioxy-diamido-arseno-benzol). Brit Med J 1, 617 (1911). Boeck, W. History, Theory and Practice of Syphilisation. New Engl J Medicine 73, 20–25 (1865). Veale, H. Remarks on Syphilis and Its Treatment. Edinb Medical J 10, 10–26 (1864). LaFond RE and Lukehart SA, Biological Basis for Syphilis. Clinical Microbiology Reviews 2006. Secher L et al, Treponema pallidum in peripheral nerve tissue of syphilitic chancres. Acta dermato-venereologica 1982. Hollander DH, Turner TB, The role of temperature in experimental treponemal infection. American journal of syphilis, gonorrhea, and venereal diseases, 1954 Eagle H, et al. The effect of hyperpyrexia on the therapeutic efficacy of penicillin in experimental syphilis. American journal of syphilis, gonorrhea, and venereal diseases, 1947. Kampmeier RH, Syphilis therapy: an historical perspective. Journal of the American Venereal Disease Association 1976. Pachner AR, Spirochetal Diseases of the CNS. Neurologic clinics, 1986. Sell S et al, Experimental syphilitic orchitis in rabbits: ultrastructural appearance of Treponema pallidum during phagocytosis and dissolution by macrophages in vivo. Laboratory investigation; a journal of technical methods and pathology, 1982. Taylor SH, Diuretics in cardiovascular therapy. Perusing the past, practising in the present, preparing for the future. Zeitschrift für Kardiologie, 1985. Ovchinnikov NM, [Treponema pallidum in peripheral nerves of rabbit syphiloma]. Vestnik dermatologii i venerologii, 1975. Cheek DB, Wu F, The Effect of Calomel on Plasma Epinephrine in the Rat and the Relationship to Mechanisms in Pink Disease, Archives of Disease in Childhood, 1959 Vogl A, The discovery of the organic mercurial diuretics, American Heart Journal, 1950 Schwemlein GX et al, Penicillin and fever therapy in early syphilis, Journal of the American Medical Association, 1948. Stringham JS, On the Diuretic Effects of Mercury in a Case of Syphilis. The Medical and physical journal, 1807 Evanson RL et al, Effect of mercurial diuretics on tubular sodium and potassium transport in the dog. The American journal of physiology, 1972 Sell S and Salman J, Demonstration of Treponema pallidum in Axons of Cutaneous Nerves in Experimental Chancres of Rabbits, Sexually Transmitted Diseases, 1992 Penn CW, Avoidance of Host Defences by Treponema pallidum in Situ and on Extraction from Infected Rabbit Testes, Microbiology 1981. 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Infection and immunity, 1992 Batterman RC et al, THE SUBCUTANEOUS ADMINISTRATION OF MERCAPTOMERIN (THIOMERIN®): Effective Mercurial Diuretic for the Treatment of Congestive Heart Failure. Journal of the American Medical Association, 1949 Batterman RC, The status of mercurial diuretics for the treatment of congestive heart failure. American Heart Journal, 1951 Bleich HL et al, The Role of Regional Body Temperature in the Pathogenesis of Disease, The New England Journal of Medicine, 1981 Vander Veer JB et al, The Prolonged Use of an Oral Mercurial Diuretic in Ambulatory Patients with Congestive Heart Failure. Circulation 1950 Cox DL et al, The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infection and immunity, 1992. Fildes P, The Mechanism of the Anti-bacterial Action of Mercury. Br J Exp Pathol, 1940 Clarkson TW, THE MECHANISM OF ACTION OF MERCURIAL DIURETICS IN RATS; THE METABOLISM OF 203Hg‐LABELLED CHLORMERODRIN. British Journal of Pharmacology and Chemotherapy, 1965 Engelkens HJ et al, The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. Genitourinary Medicine, 1993 Belum GR et al, The Jarisch–Herxheimer reaction: Revisited. Travel Medicine and Infectious Disease, 2013 Arando M et al, The Jarisch–Herxheimer reaction in syphilis: could molecular typing help to understand it better? Journal of the European Academy of Dermatology and Venereology, 2018. Butler T, The Jarisch–Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis. The American Journal of Tropical Medicine and Hygiene, 2016 Carlson JA et al, The Immunopathobiology of Syphilis: The Manifestations and Course of Syphilis Are Determined by the Level of Delayed-Type Hypersensitivity. The American Journal of Dermatopathology 2011. Aronson IK and Soltani K, The enigma of the pathogenesis of the Jarisch-Herxheimer reaction. The British Journal of Venereal Diseases, 1976 Sellato TJ et al, The Cutaneous Response in Humans to Treponema pallidum Lipoprotein Analogues Involves Cellular Elements of Both Innate and Adaptive Immunity, The Journal of Immunology 2001 Spiller HA, Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clinical Toxicology 2017 Sell S et al, Reinfection of chancre-immune rabbits with Treponema pallidum. I. Light and immunofluorescence studies. The American journal of pathology 1985. Grant SS and Hung DT, Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response, Virulence 2013 Lant AF, Modern diuretics and the kidney. Journal of Clinical Pathology, 1981 Kamath SU et al, Mercury-based traditional herbo-metallic preparations: a toxicological perspective, Archives of Toxicology 2012. Yeter et al, Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome. Korean Circulation Journal 2013 Wöβmann W et al, Mercury intoxication presenting with hypertension and tachycardia. Archives of Disease in Childhood, 1999 Giacani L et al, Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) Regulon and Its Implications for Pathogen Persistence in the Host and Syphilis Pathogenesis. Journal of Bacteriology 2013. Edwards AM, From tooth to hoof: treponemes in tissue‐destructive diseases. Journal of Applied Microbiology, 2003 Wolgemuth CW, Flagellar motility of the pathogenic spirochetes. Seminars in Cell & Developmental Biology 2015. Solomon HC and Kopp I, Fever Therapy. The New England Journal of Medicine 1937. Rice KM et al, Environmental Mercury and Its Toxic Effects. Journal of Preventive Medicine and Public Health 2014. Drusin LM, Electron microscopy of Treponema pallidum occurring in a human primary lesion. Journal of bacteriology 1969. McNeely MC et al, Cutaneous secondary syphilis: Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis. Journal of the American Academy of Dermatology 1986. Borenstein LA et al, Contribution of rabbit leukocyte defensins to the host response in experimental syphilis. Infection and immunity 1991. Cabot RC et al, Case 51-1976 — Bicentennial CPC — Syphilis, Diarrhea and Death in the 1820's. The New England Journal of Medicine 1976. Hobman JL and Crossman LC, Bacterial antimicrobial metal ion resistance. Journal of Medical Microbiology 2015 Gelpi A and Tucker JD, After Venus, mercury: syphilis treatment in the UK before Salvarsan. Sexually Transmitted Infections 2015. MacHaffie et al, A study of the effectiveness of mercurial diuretics in treatment of cardiac decompensation. The American Journal of Cardiology 1958 Aberer W et al, Ammoniated mercury ointment: outdated but still in use. Contact Dermatitis 1990 Farhi D, Dupin N, Origins of syphilis and management in the immunocompetent patient: Facts and controversies. Clinics in Dermatology (2010) 28, 533–538 Frith J, “Syphilis – Its early history and Treatment until Penicillin and the Debate on its Origins,” Journal of Military and Veterans’ Health, 20(4), retrieved online at: http://jmvh.org/article/syphilis-its-early-history-and-treatment-until-penicillin-and-the-debate-on-its-origins/ Howes OD et al, “Julius Wagner-Jauregg, 1857-1940,” American Journal of Psychiatry, April 2009 Volume 166 Number 4, Volume 166, Issue 4, April, 2009, pp. 409-409. Karamanou M et al, “Julius Wagner-Jauregg (1857-1940): Introducing fever therapy in the treatment of neurosyphilis.” Psychiatriki. 2013 Jul-Sep;24(3):208-12. Simpson WM, “Artificial fever therapy of syphilis,” JAMA. 1935;105(26):2132-2140. Tsay CJ, “Julius Wagner-Jauregg and the Legacy of Malarial Therapy for the Treatment of General Paresis of the Insane,” Yale J Biol Med. 2013;86(2): 245–254 Wagner-Jauregg J, “The history of malaria treatment of general paralysis.” Am J Psychiatry. 1946;02: 577-582 Shafer JK et al, Untreated syphilis in the male Negro: A prospective study of the effect on life expectancy. Public Health Rep. 1954 Jul; 69(7): 684–690. Abara WE et al, Syphilis Trends among Men Who Have Sex with Men in the United States and Western Europe: A Systematic Review of Trend Studies Published between 2004 and 2015. PLoS One. 2016; 11(7): e0159309. Nutton V, The Reception of Fracastoro's Theory of Contagion: The Seed That Fell among Thorns? Osiris, Vol. 6, Renaissance Medical Learning: Evolution of a Tradition (1990) Tsaraklis A, Preventing syphilis in the 16th century: the distinguished Italian anatomist Gabriele Falloppio (1523-1562) and the invention of the condom. 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Episode 8 of the Get Work Savvy podcast brings you the inspiring story of how Yasmin discovered the world of Biomedical Science after originally looking to become a Doctor.Join me as I discover what a Biomedical Scientist does, how Yasmin was offered a place on a course she hadn’t applied for and how you can use the advice she offers in your quest to find your dream job.Books:Obedience to Authority: An Experimental View by Stanley MilgramAmazon link - https://amzn.to/2SNSfwUOn the Origin of Species by Charles DarwinAmazon link - https://amzn.to/2UO9zDFTrust Me I'm a Junior Doctor by Max PembertonAmazon link - https://amzn.to/2rEanhqThe Essential Turing: Seminal Writings in Computing, Logic, Philosophy, Artificial Intelligence, and Artificial Life plus The Secrets of Enigma by Alan TuringAmazon link - https://amzn.to/2Qvu4XvWebsite and useful links recommended by Yasmin:- PLOS - Public Library of Science https://www.plos.org/- The British Science Festival is a great way of learning about what's going on in the world of science and the chance to meet all kinds of scientists, so great for networkinghttps://www.britishscienceassociation.org/british-science-festival- The Royal Society of Biology's website has a great career sectionhttps://www.rsb.org.uk/careers-and-cpd - Professional societies; there's a 'Society of...' pretty much every specialty so if someone has interest in a specific field of science Yasmin recommends finding which it is to check out the website and sign up for mailing lists etc and if actively pursuing this kind of career becoming a member of one, they have benefits and great opportunities - for example attendees got to meet Sir David Attenborough a few weeks ago as he had been a member of the Society for Applied Microbiology since he was a student! - The Science and Natural History Museums always have been and still are a worthwhile visit, or local equivalents if far from London. Bristol has a science center called We The Curious for example. - I'm a Scientist Get Me Out of Here; primarily held for school students of connect and ask scientists anything, there's a few competitions a year where scientists compete. A great example of public outreach and you can see lots of previous Q&As and has career zonehttps://imascientist.org.uk/Quote: "However difficult life may seem, there is always something you can do and succeed at." - Stephen Hawking"No results is still an answer." YasminKey takeaways:Doors will open without you knowing. If people see the good work you are doing and if you show the right drive and passion then when an opening presents itself, they will remember you.Take a chance! – If you don’t ask the question you will never know. If you decide to quit then you are guaranteed failure.Volunteer – by volunteering you have the chance to learn about your chosen career path and quite often you will learn or experience things that will be valuable later.It’s ok to be unsure – often people worry about being unsure, but remember the experts started somewhere. If in doubt, go with your gut. It's better to make a decision and be wrong than to stay stuck deliberating the perfect solution.There will be hard times – try to avoid being overly critical, find a way to remember why you are doing this.Exams wont stay wha
Stewart White CEO of #Collagen Solutions provides a trading update. "...expect a valuation 100 million pounds by 2020" Collagen Solutions Plc is a global provider of medical grade collagen formulations and components for use in regenerative medicine, medical devices and in-vitro diagnostics. Dr Stewart White was CEO of Collbio and has recent and direct board experience of an AIM quoted company. Stewart has international experience in operations, business and product development, and 'Good Manufacturing Practices' (GMP) compliant manufacturing of collagen medical devices, advanced biologics and Active Pharmaceutical Ingredients in both Small to Medium Enterprises as well as global pharmaceutical companies. Stewart is a graduate of the University of Strathclyde and holds a First Class degree in Applied #Microbiology, a Ph.D. in Fermentation #Technology and Bioprocessing and an MBA. For more #investing news and #interviews visit: www.directorstalk.com
On the evening of 30 June 2014, in Brighton, the SfAM Summer Conference began with the annual Journal of Applied Microbiology Annual Lecture, chaired by SfAM President, Professor Martin Adams. Professor George Macfarlane speaks on the topic of 'bacterial metabolism in the large intestine and its consequences for the host'.
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