Podcasts about botulinum

Is looking wrinkle-free really worth injecting a neurotoxin that could mess with your brain, body, and hormones? In this eye-opening episode, I'm joined by truth-teller and health advocate Gretch Elizabeth from NeverTox to pull back the curtain on one of the most accepted—and least questioned—cosmetic procedures: Botox. What if the pursuit of smooth skin is quietly sabotaging your health? Gretch breaks down the science behind botulinum toxin—the neurotoxin that, with repeated injections, may have long-term, life-threatening consequences. This is the conversation every woman deserves before saying “yes” to the needle. Gretch Elizabeth is a passionate patient advocate who helps run the Never Tox Community Group—the largest international Botox injury support group in the world—dedicated to supporting individuals affected by botulinum toxin injuries through resources and education. Gretch and her team have worked tirelessly to promote informed consent. We're talking facts, risks, and informed alternatives—because you should never have to choose between beauty and health. **Follow, subscribe, and leave a review if this episode challenged what you've been told and opened your eyes to better options. ✴️ Connect with Gretch on Facebook, Instagram, Threads, or YouTube

Summary In this episode of the Future of Dermatology Podcast, we hear from Dr. Maria Aleshin who spoke at the Annual SF Derm Society's 2024 Meeting. She presents on Hidradenitis Suppurativa (HS) and various non-biologic treatment strategies. Dr. Aleshin covers practical approaches to managing HS flare-ups, long-term management considerations, and the role of antibiotics in treatment. She emphasizes the importance of personalized care and the need for a multifaceted approach to effectively address this challenging skin condition.   Takeaways The pathogenesis of HS is multifactorial, requiring a comprehensive treatment approach. Treatment stacking often involves combining medical, procedural, and lifestyle interventions. Topical therapies like chlorhexidine and benzoyl peroxide are commonly recommended, but alternatives exist. Systemic antibiotics are frequently used for managing HS flares. Hormonal therapies, including oral contraceptives and spironolactone, can be effective for female patients with HS. Metformin may be beneficial for patients with metabolic dysfunction associated with HS. Isotretinoin is not a first-line treatment for HS due to mixed results. Botulinum toxin can help reduce sweating and inflammation in HS patients. Combination antibiotic therapy, particularly clindamycin and rifampin, shows high efficacy but has relapse risks. Urtipenem is a powerful antibiotic reserved for severe HS cases as a bridge to surgery or biologics. Chapters 00:00 - Introduction to the Future of Dermatology Podcast 01:19 - Understanding Hidradenitis Suppurativa (HS) and Its Complexities 07:10 - Treatment Strategies for Managing HS Flare-Ups 10:21 - Long-Term Management of HS: Hormonal and Metabolic Considerations 13:20 - Antibiotic Therapies for Hidradenitis Suppurativa 17:22 - Severe HS Cases: Advanced Treatment Options and Considerations

Czy w dzisiejszym świecie mamy obowiązek być idealni? Mieć usta, oczy i policzki prosto z katalogu? Czy jest jeszcze przestrzeń na to, żeby zwyczajnie być sobą, niepowtarzalnym i pięknym w tej niepowtarzalności? Takiej przestrzeni jest coraz mniej, dlatego istotne jest, że pojawiają się w medycynie nowe nurty, które chcą nas wspomagać w utrzymaniu pięknego wyglądu, opóźniać pojawienie się oznak starzenia, ale bez użycia toksyny botulinowej czy wypełniaczy. O tym, czy to dobry kierunek, w podcaście "Zdrowie bez cenzury" rozmawiamy z Klaudią Witczak, przedsiębiorczynią, założycielką i właścicielką kliniki medycyny regeneracyjnej skóry Smart Aging Clinic. Źródła badań przywołanych w trakcie rozmowy: 1. Witmanowski H., Błochowiak K. Postępy Dermatologii i Alergologii, 2020 Oct;37(5):651-659, https://pmc.ncbi.nlm.nih.gov/articles/PMC7675084/, data dostępu: 09.12.2024 r. 2. George Kroumpouzos MD, Martin Kassir MD, Mrinal Gupta MD, Anant Patil MD, Mohamad Goldust MD. Complications of Botulinum toxin A: An update review. Journal of Cosmetic Dermatology, vol. 20 (6): 1585-1590, https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.14160, data dostępu: 09.12.2024 r. 3. Peszyńska-Drews K. Badania.net, 2012, https://www.badania.net/prawda-zapisana-na-twarzy/, data dostępu: 09.12.2024 r. 4. Kenny Rose Anne. Age Proof - The New Science of Living a Longer and Healthier Life (extracts from book). The Irish Longitudinal Study on Aging (TILDA), 2022, https://tilda.tcd.ie/news-events/2022/2201-AgeProof-bookrelease-extracts/, data dostępu: 09.12.2024 r.

Summary In this episode of The Future of Dermatology Podcast, Dr. Faranak Kamangar discusses hyperhidrosis, a common condition characterized by excessive sweating. The conversation covers the causes, prevalence, and various treatment options available, including topical treatments, botulinum toxin injections, oral medications, and advanced technologies like ionophoresis and miradry. Dr. Kamangar emphasizes the importance of patient education and setting realistic expectations for treatment outcomes.   Takeaways Hyperhidrosis is often diagnosed by patients before seeing a doctor. The condition can be debilitating and affects various aspects of life. Most cases of hyperhidrosis are primary, with few secondary causes. Topical antiperspirants are the first line of treatment. Setting expectations is crucial for patient satisfaction with treatments. Botulinum toxin is effective but can be painful for patients. Oral medications can be used but have contraindications. Ionophoresis is a viable option for some patients. Emerging technologies like microneedling for botulinum toxin show promise. Patient education is key to managing hyperhidrosis effectively.   Chapters 00:00 - Introduction to Hyperhidrosis 02:45 - Understanding Hyperhidrosis: Causes and Prevalence 06:00 - First-Line Treatments for Hyperhidrosis 09:13 - Advanced Treatment Options: Botulinum Toxin and Microneedling 11:51 - Oral Medications and Ionophoresis 15:06 - Injectable Treatments and Patient Management 17:47 - Emerging Technologies and Future Directions in Treatment

Episode 268 hosts Dr Steven Weiner, a Facial Plastic Surgeon from Florida, USA.  Back on July 11th, Steve and another previous IA guest April Harrison did an Instagram Live together where they discussed their thoughts and aproach to botulinum toxin resistance in their own patients - including a very novel (and controversial!) approach to using hyaluronidase to 'cure' it. In our 'What's trending in Aesthetics?' episodes we cover topics that have got injectors talking on social media or been in the news. We'll cover controversies, big stories and themes that affect our speciality. In Chapter 5 Part 1 (free for listeners on any podcast app), we explore: Botulinum toxin resistance Theories around what happens with the immune system to cause toxin resistance The issue of 'pseudo-resistance' How to approach suspected toxin resistance in patients  In Chapter 5 Part 2 (exclusive for subscribers to our Patreon) we cover: The background to why they looked at using hyaluronidase for toxin resistance April's toxin resistance case Steve's theories about how hyaluronidase might work LISTEN TO PART 2 BY SUBSCRIBING TO OUR PATREON Starting from episode 265 you'll notice that a proportion of our episodes are now divided into two parts: Part 1 is free & available on any podcast app Part 2 is exclusive for subscribers to our Patreon and these episodes are only available on Spotify for now Once you've joined Patreon, here's a guide on how to set things up in Patreon to access the subscriber-only episodes CLICK HERE TO BROWSE OUR IA OFFERS FOR DISCOUNTS & SPECIALS Save money, access special promotions and more! CLICK HERE IF YOU'RE A BRAND OR COMPANY & WANT TO WORK WITH IA Contact us if you'd like to: Discuss a sponsored podcast idea Maybe you'd like to set up an IA Offer (a special discount for our listeners) Reward and gift your most loyal & valued customers with an annual subscription to our Patreon CLICK HERE TO APPLY TO BE A GUEST ON IA Do you have a great story for an 'Injector Diaries' episode? Would you like to share your business model and strategies on a 'Business of Injecting' episode? Do you have exceptional experience with toxins and want to do a 'Tox Talks' episode? Are you a leading expert using fillers, polynucleotides, exosomes or other injectbale products and want to contribute to our 'Masterclass Series' series? Has something especially got your attention on social media that's worth delving into on a 'What's trending in aesthetics? episode? CONTACT INFORMATION:  Contact IA and other important links Subscribe to IA on Apple Podcasts Subscribe to IA on Spotify Follow Dr Jake on Instagram  Follow David on Instagram

Cervical dystonia (sometimes called neck dystonia) is the abnormal position of the muscles of the neck, causing a twisted, turned, flexed or extended neck position. Abnormal signals coming from the deep parts of the brain cause this condition and therefore it is not muscular in nature and will not resolve with muscle massage or stretching.The mainstay of treatment of cervical dystonia is with injection of botulinum toxin, such as Botox or Xeomin. Botulinum toxin injections work by causing a disruption between the nerve and the muscle, thereby weakening the muscle that it is injected into. For cervical dystonia, because the muscles that are pulling or twisting the neck to one side are overactive, Botox works to calm those specific muscles down and allows for a more natural and neutral head position.

Die Medizin unterscheidet meist noch immer zwischen psychisch, somatisch und psychosomatisch. Doch der Blick auf Symptome und molekulare Mechanismen zeigt: Zeit für einen Systemwechsel. Yasmin Appelhans hat sich die medizinischen Graubereiche angesehen und festgestellt, dass sie erstaunlich weit reichen: vom Herzinfarkt durch das Broken-Heart-Syndrom über ein verändertes Mikrobiom durch Stress bis hin zu dem irritierenden Verlangen, Papier zu essen bei Mangelerscheinungen. Sie lässt Forschende verschiedener Disziplinen über die Chancen einer integrierten Medizin zu Wort kommen - und berichtet im Gespräch mit Host Lucie Kluth, wie ein Facharzt ihr nach einer Entzündung mit einem einfachen Trick ihre verlorene Stimme zurückgab. HINTERGRUNDINFORMATIONEN Gough J. What Makes a Disorder ‘Mental'? A Practical Treatment of Psychiatric Disorder: https://philpapers.org/rec/GOUWMA-2 Nacul L, O'Boyle S, Palla L, Nacul FE, Mudie K, Kingdon CC, et al. How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS: https://pubmed.ncbi.nlm.nih.gov/32849252/ Park C, Majeed A, Gill H, Tamura J, Ho RC, Mansur RB, et al. The Effect of Loneliness on Distinct Health Outcomes: A Comprehensive Review and Meta-Analysis: https://pubmed.ncbi.nlm.nih.gov/33130511/ Leib-Seele-Problem: https://www.spektrum.de/lexikon/psychologie/leib-seele-problem/8687 Metzger FD| Nadine. Krankheit als Werturteil: https://www.bpb.de/shop/zeitschriften/apuz/270305/krankheit-als-werturteil/ Microbiota–brain axis: Context and causality: https://www.science.org/doi/abs/10.1126/science.abo4442 Haensch CA, Wagner C, Mallien J, Isenmann S. Posturales Tachykardiesyndrom: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1628499 Coles NA, March DS, Marmolejo-Ramos F, Larsen JT, Arinze NC, Ndukaihe ILG, et al. A multi-lab test of the facial feedback hypothesis by the Many Smiles Collaboration: https://pubmed.ncbi.nlm.nih.gov/36266452/ Kuru Alici N, Arikan Dönmez A. A systematic review of the effect of laughter yoga on physical function and psychosocial outcomes in older adults: https://www.sciencedirect.com/science/article/abs/pii/S1744388120311270?via%3Dihub Schulze J, Neumann I, Magid M, Finzi E, Sinke C, Wollmer MA, et al. Botulinum toxin for the management of depression: An updated review of the evidence and meta-analysis: https://www.sciencedirect.com/science/article/abs/pii/S0022395621000236?via%3Dihub Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, et al. Exercise Therapy for Fibromyalgia: https://link.springer.com/article/10.1007/s11916-011-0214-2 NHS England. Social prescribing: https://www.england.nhs.uk/personalisedcare/social-prescribing/ Mehr Hintergrund zu dieser Folge: https://www.ndr.de/nachrichten/info/podcastsynapsen394.html Wissenschaft bei NDR Info: https://www.ndr.de/nachrichten/info/sendungen/wissenschaft-und-bildung/index.html

Die Medizin unterscheidet meist noch immer zwischen psychisch, somatisch und psychosomatisch. Doch der Blick auf Symptome und molekulare Mechanismen zeigt: Zeit für einen Systemwechsel. Yasmin Appelhans hat sich die medizinischen Graubereiche angesehen und festgestellt, dass sie erstaunlich weit reichen: vom Herzinfarkt durch das Broken-Heart-Syndrom über ein verändertes Mikrobiom durch Stress bis hin zu dem irritierenden Verlangen, Papier zu essen bei Mangelerscheinungen. Sie lässt Forschende verschiedener Disziplinen über die Chancen einer integrierten Medizin zu Wort kommen - und berichtet im Gespräch mit Host Lucie Kluth, wie ein Facharzt ihr nach einer Entzündung mit einem einfachen Trick ihre verlorene Stimme zurückgab. HINTERGRUNDINFORMATIONEN Gough J. What Makes a Disorder ‘Mental'? A Practical Treatment of Psychiatric Disorder: https://philpapers.org/rec/GOUWMA-2 Nacul L, O'Boyle S, Palla L, Nacul FE, Mudie K, Kingdon CC, et al. How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS: https://pubmed.ncbi.nlm.nih.gov/32849252/ Park C, Majeed A, Gill H, Tamura J, Ho RC, Mansur RB, et al. The Effect of Loneliness on Distinct Health Outcomes: A Comprehensive Review and Meta-Analysis: https://pubmed.ncbi.nlm.nih.gov/33130511/ Leib-Seele-Problem: https://www.spektrum.de/lexikon/psychologie/leib-seele-problem/8687 Metzger FD| Nadine. Krankheit als Werturteil: https://www.bpb.de/shop/zeitschriften/apuz/270305/krankheit-als-werturteil/ Microbiota–brain axis: Context and causality: https://www.science.org/doi/abs/10.1126/science.abo4442 Haensch CA, Wagner C, Mallien J, Isenmann S. Posturales Tachykardiesyndrom: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1628499 Coles NA, March DS, Marmolejo-Ramos F, Larsen JT, Arinze NC, Ndukaihe ILG, et al. A multi-lab test of the facial feedback hypothesis by the Many Smiles Collaboration: https://pubmed.ncbi.nlm.nih.gov/36266452/ Kuru Alici N, Arikan Dönmez A. A systematic review of the effect of laughter yoga on physical function and psychosocial outcomes in older adults: https://www.sciencedirect.com/science/article/abs/pii/S1744388120311270?via%3Dihub Schulze J, Neumann I, Magid M, Finzi E, Sinke C, Wollmer MA, et al. Botulinum toxin for the management of depression: An updated review of the evidence and meta-analysis: https://www.sciencedirect.com/science/article/abs/pii/S0022395621000236?via%3Dihub Busch AJ, Webber SC, Brachaniec M, Bidonde J, Bello-Haas VD, Danyliw AD, et al. Exercise Therapy for Fibromyalgia: https://link.springer.com/article/10.1007/s11916-011-0214-2 NHS England. Social prescribing: https://www.england.nhs.uk/personalisedcare/social-prescribing/ Mehr Hintergrund zu dieser Folge: https://www.ndr.de/nachrichten/info/podcastsynapsen394.html Wissenschaft bei NDR Info: https://www.ndr.de/nachrichten/info/sendungen/wissenschaft-und-bildung/index.html

ชมวิดีโอ EP นี้ใน YouTube เพื่อประสบการณ์การรับชมที่ดีที่สุด ปัจจุบันอุตสาหกรรมความงามด้านการแพทย์เติบโตขึ้นเรื่อยๆ เนื่องจากคนรุ่นใหม่ให้ความสนใจกับสุขภาพและร่างกาย ประกอบกับนวัตกรรมความงามที่พัฒนาอย่างก้าวหน้า กลายเป็นโอกาสในตลาดความงาม หนึ่งในนั้นคือ Apex Hospital & Beauty clinic ผู้บุกเบิกความงามที่นำเข้าเทคโนโลยีสู่เมืองไทยเมื่อหลายสิบปีก่อน เช่น Botulinum toxin, สารเติมเต็ม, เครื่องสลายไขมันด้วยความเย็น ซึ่งก่อตั้งโดยหมอผิวหนังที่เรียนจบจากอเมริกา ได้เห็นความต้องการของผู้บริโภค ประกอบกับเป็นผู้ติดตามความเคลื่อนไหวเทรนด์เทคโนโลยีความงาม จึงเป็นจุดเริ่มต้นสร้างธุรกิจความงามที่สร้างรายได้มหาศาลและมีชื่อเสียงโด่งดังในปัจจุบันนี้ เบื้องหลังความสำเร็จคืออะไร เคน นครินทร์ พูดคุยกับ พญ.นันทภัทร์ สุภาพรรณชาติ ผู้ก่อตั้ง Apex Hospital & Beauty Clinic ถึงวิสัยทัศน์และกลยุทธ์พลิกเกมธุรกิจด้วยนวัตกรรม ติดตามชมได้ใน The Secret Sauce เอพิโสดนี้ ฆสพ.สบส.110/2561 

ปัจจุบันอุตสาหกรรมความงามด้านการแพทย์เติบโตขึ้นเรื่อยๆ เนื่องจากคนรุ่นใหม่ให้ความสนใจกับสุขภาพและร่างกาย ประกอบกับนวัตกรรมความงามที่พัฒนาอย่างก้าวหน้า กลายเป็นโอกาสในตลาดความงาม หนึ่งในนั้นคือ Apex Hospital & Beauty clinic ผู้บุกเบิกความงามที่นำเข้าเทคโนโลยีสู่เมืองไทยเมื่อหลายสิบปีก่อน เช่น Botulinum toxin, สารเติมเต็ม, เครื่องสลายไขมันด้วยความเย็น ซึ่งก่อตั้งโดยหมอผิวหนังที่เรียนจบจากอเมริกา ได้เห็นความต้องการของผู้บริโภค ประกอบกับเป็นผู้ติดตามความเคลื่อนไหวเทรนด์เทคโนโลยีความงาม จึงเป็นจุดเริ่มต้นสร้างธุรกิจความงามที่สร้างรายได้มหาศาลและมีชื่อเสียงโด่งดังในปัจจุบันนี้ เบื้องหลังความสำเร็จคืออะไร เคน นครินทร์ พูดคุยกับ พญ.นันทภัทร์ สุภาพรรณชาติ ผู้ก่อตั้ง Apex Hospital & Beauty Clinic ถึงวิสัยทัศน์และกลยุทธ์พลิกเกมธุรกิจด้วยนวัตกรรม ติดตามชมได้ใน The Secret Sauce เอพิโสดนี้ ฆสพ.สบส.110/2561

In der heutigen Folge des Podcasts spricht die Neurologin Dr. Elvira Steidl über den Einsatz von Botulinum-Neurotoxin (BoNT) in der Neurologie. Sie erläutert die Wirkungsweise von BoNT und erklärt, in welchen medizinischen Bereichen es eingesetzt wird. Denn BoNT kann weit mehr als nur in der ästhetischen Medizin verwendet werden. Diese Folge wird mit freundlicher Unterstützung von Merz präsentiert.

Send us a Text Message.Dr. David Boucher, Ph.D. is Director, Infectious Disease Preparedness and Response, Administration for Strategic Preparedness and Response, U.S. Department of Health and Human Services ( https://aspr.hhs.gov/Pages/Home.aspx ).The HHS Administration for Strategic Preparedness and Response (ASPR) leads the nation's medical and public health preparedness for, response to, and recovery from disasters and other public health emergencies.ASPR collaborates with hospitals, healthcare coalitions, biotech firms, community members, state, local, tribal, and territorial governments, and other partners across the country to improve readiness and response capabilities.Dr. Boucher previously held several other critical roles in the organization, including as Chief of the Antivirals & Antitoxins branch at BARDA's Anthrax, Botulinum, Ebola and Smallpox therapeutics program office, Acting Director for the Administration for Strategic Preparedness and Response's Office of Industrial Base Management and Supply Chain (IBM/SC) and serving as HHS's lead negotiator for product development/procurement agreements for COVID-19 medical countermeasures.Dr. Boucher has a Bachelor of Science (B.S.), Genetics, and a Doctor of Philosophy (PhD), Biochemistry and Molecular Biology from University of California, Davis.Support the Show.

In this episode Toni Street talks with Penny Chapman of Caci about all things skin health. They discuss what you can do to protect your skin and the services Caci provides to help you take control of your skin. Penny Chapman has been with Caci for 15 years, starting out as a franchise owner in New Plymouth, and has now gone on to become the General Manager. Feel Confident in your Skin This episode is bought to you by Caci   Botulinum toxin injections are prescription medicine for the treatment of frown lines , horizontal forehead lines and crow's feet round the eyes. Botulinum toxin injections have risks and benefits. Ask your doctor if botulinum toxin injection is right for you. If you have side effects, see your doctor. You will need to pay for your botulinum toxin injection and clinic fees will apply. For details on precautions & side effects consult your doctor or go to www.medsafe.govt.nz . Botulinum toxin injections lasts about 4 months and further courses of treatment may be necessary. Should only be administered by trained medical professionals.See omnystudio.com/listener for privacy information.

Botulinum toxin, also known as Botox, is not as scary as it sounds. It is primarily known for its ability to reduce the appearance of facial wrinkles and fine lines by temporarily relaxing the muscles responsible for causing them. It's administered through injections and typically lasts for several months before gradually wearing off. Botox has become incredibly popular worldwide, with millions of procedures performed each year, making it one of the most well-known cosmetic treatments available. Join Cinddie as she learns all about Botox and Microbotox from Dr. Terence Tan of Halley Medical Aesthetics In this episode, the followingg points are covered: What is Botox and how does it work? Where can Botox be used? What are the aftercare tips for Botox? The temporary side effects of Botox For more information on medical aesthetic treatments, follow Halley Medical Aesthetics on: • Facebook• Instagram• YouTube Learn more from the doctors at Halley Medical Aesthetics! Schedule your appointment with them: Tel: +65 6737 8233Email: info@halley.com.sgWhatsApp: +65 9816 6148Address: 277 Orchard Road #03-15 orchardgateway Singapore 238858

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 Yes, we have harnessed the power of paralysis. Botulinum toxin, which is produced by a lethal bacterium, Clostridium botulinum, has been bottled and sold to neurologists for decades. And you know this because you've seen people who received Botox to relax their facial muscles. In this week's installment, Dr. Anh-Thu Vu discusses how neurologists utilize this neurotoxic agent. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision-making in routine clinical practice. The content in this episode was vetted and approved by Anh-Thu Vu. REFERENCES Arnon SS, Schechter R, Inglesby TV, et al. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2001;285(8):1059-70. Erratum in: JAMA 2001;285(16):2081. PMID 11209178Aurora SK, Winner P, Freeman MC, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache 2011;51(9):1358-73. PMID 21883197Dauer WT, Burke RE, Greene P, Fahn S. Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia. Brain. 1998 Apr;121 ( Pt 4):547-60. PMID 9577384Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. Mov Disord 2009;24(6):801-12. PMID 19224614Karp BI. Botulinum toxin treatment of occupational and focal hand dystonia. Mov Disord 2004;19 Suppl 8:S116-9. PMID 15027063Lotia M, Jankovic J. Botulinum toxin for the treatment of tremor and tics. Semin Neurol 2016;36(1):54-63. PMID 26866497Naumann M, Dressler D, Hallett M, et al. Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon 2013;67:141-52. PMID 23178324Thenganatt MA, Fahn S. Botulinum toxin for the treatment of movement disorders. Curr Neurol Neurosci Rep 2012;12(4):399-409. PMID 22661378  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

Why did Avraham Avinu, who deeply trusted his servant Eliezer with everything, make him swear an oath when finding a shidduch for Yitzchak? We're unraveling this intriguing narrative, discussing the peculiarities around the honorifics and the customs of the Tzadikim. We're presenting an in-depth exploration that will illuminate Avraham's motivation for this oath and its role in ensuring Eliezer's success in his mission. Setting boundaries protects us from the dangerous and toxic sins in life. Join our thoughtful discourse on boundaries, their connection to Avraham's life, and their potential to set a protective tone. We're focusing on recognizing the perils of specific sins and the proactive measures we can adopt to defend ourselves. We'll discuss practical enactments to help maintain Satan as we wrap up. This episode promises to enrich your understanding of religious traditions, customs, and lessons. Don't miss out on this enlightening journey.Support the show------------------Check out our other Torah Podcasts and content! SUBSCRIBE to The Motivation Congregation Podcast for daily motivational mussar! Listen on Spotify or the new Jewish music and Podcast streaming platform 24six! Find all Torah talks and listen to featured episodes on our new website, themotivationcongregation.org Questions or Comments? Please email me @ michaelbrooke97@gmail.com#parsha #shortdvartorah #thetorahpodcast #motivationalmussar

Neste episódio conversamos com ex-presidente da SBOP, Dra Luisa Hopker, sobre o subespecialty day da WSPOS, em Viena. Abordamos os temas e trabalhos mais discutidos como:- ambliopia e formas de screening na Indonesia e seguimento de crianças pretermo- técnicas cirúrgicas para esotropia por insuficiência de divergência, miopexia retroequatorial para oblíquo inferior - exotropia intermitente (quando e como operar)- toxina botulínica para IV par- miopiaAbaixo, seguem os links e referências citadas neste episódio:1. Diretriz SBOP de exame na infância  (Brazilian guidelines on the frequency of ophthalmic assessment and recommended examinations in healthy children younger than 15 years (https://pubmed.ncbi.nlm.nih.gov/34431876/)2. Management of  intermittent exotropia in childhood current concepts of the literature and the experts. (https://pubmed.ncbi.nlm.nih.gov/36350932/)Subespecialty program:  https://wspos.org/wp-content/uploads/2023/09/A3V2.pdf3. Screening in Indonesia (Kianti Darusman)4. Management of amblyopia in premature babies (Kateryna Fedchuk)5. Lateral Rectus Superior Plication for  Divergence Insufficiency Esotropia (Yair Morad)6. Retroequatorial inferior obliqúe myopia for treatment of inferior oblique strabismus cases (Heba Metwally)7. Botulinum toxin and surgical management of sixth nerve palsy (Luisa Hopker)8. Management of head tilt due to nystagmus (Ramesh Kekunnaya)9. Botulinum toxin as first-line treatment in acquired fourth nerve paresis (Paulo Loureiro)

Ever wondered how a renowned poet's death can lead to a twisty mystery entwined with the hidden world of lethal bacteria? Prepare to be enthralled as we join forces with Dr. Alfredo Torres, a renowned figure in Microbiology and Immunology, to unravel the curious puzzle surrounding the death of the celebrated Chilean poet and diplomat, Pablo Neruda. This episode swings the spotlight on Neruda's life and alleged assassination using the deadly clostridium botulism. Not just that, we take you through the history-laced alleys of Neruda's poetry, his diplomatic voyages, and his ties to the artistic community in Mexico and the socialist party in Chile.Then, we switch gears to an in-depth exploration of clostridium botulinum— a soil bacteria of lethal proportions. Discover the unseen dangers lurking in your pantry, the scientific marvel behind Botox, and the deadly dance of botulism toxin with your cells. As we unravel these threads, we'll journey into the enigma of Neruda's death, connecting the dots between his alleged assassination and the chilling realities of botulism. Before we sign off, we open the floor for you, our listeners. Share your insights, ask your questions, and engage with the nuances of this scientific mystery. Don't forget to subscribe, drop your reviews, and share the intrigue with your friends. Remember, curiosity doesn't kill the cat here; it fuels the mystery! Stay tuned, stay curious, and most importantly, stay healthy!Thanks for listening to the Infectious Science Podcast. Be sure to visit infectiousscience.org to join the conversation, access the show notes, and don't forget to sign up for our newsletter to receive our free materials. We hope you enjoyed this new episode of Infectious Science, and if you did, please leave us a review on Apple Podcasts and Spotify. Please share this episode with others who may be interested in this topic! Also, please don't hesitate to ask questions or tell us which topics you want us to cover in future episodes. To get in touch, drop us a line in the comment section or send us a message on social media. Twitter @Infectious_SciInstagram @tick_virusFacebook Infectious Science PodcastSee you next time for a new episode!

The decision to diminish fine lines and look our best via a noninvasive injection weighs heavily on both women and men today. If you have used, or are considering using, Botox, also known as Botulinum neurotoxin serotype A, you don't want to miss this episode. Botox is big business; the global Botulinum Toxins Market is projected to grow from $7.49 billion in 2023 to $10.62 billion by 2030. But, besides the price tag, is there a cost to the user's health long-term? Especially considering researchers at The University of Queensland have shown how Botox is transported via our nerves back to the central nervous system. Our guest, Emily Trampetti, is a Master Licensed Esthetician and founder of Skin Property is here to shed light on this dark side of our obsession for a more youthful appearance. KEY TAKEAWAYS ·         Why someone listening should avoid Botox and its competitors. ·         The long-term effects most people don't know about. ·         Some of the psychological beauty factors that push the hype of Botox and other invasive preventative measures. ·         How some clinics and companies are breaking the law by advertising Botox and even purchasing Botox illegally. ·         Tips to age well and with grace. ·         Factors people should people be paying attention to as they age, and when. If you suffer from various skin issues including acne, severe dryness, rosacea, eczema, and even premature wrinkles, head over to skinproperty.co to learn more or book a consultation with Emily. We'll have the links to all of the links in the show notes at Ronandlisa.com/Podcast.

Plasma cells and derm with Dr. Alicia Schnebelen - Subcutaneous fat necrosis of the newborn - Lenabasum: A cannabinoid for dermatomyositis - Botulinum toxin for Hailey-Hailey and Darier's disease - Dr. Schnebelen's lab: https://pathnetlab.com/ Alicia Schnebelen on social media: https://www.instagram.com/skinandscope/?hl=en https://twitter.com/skinandscope?lang=en Check out our video content on VuMedi!: https://www.vumedi.com/channel/dermasphere/ Luke's PDPC course and the Intermountain Derm Society meeting: ⁠⁠⁠https://registration.socio.events/e/idspdpc23/promo-codes/ATTENDEE⁠⁠ The University of Utah's Dermatology ECHO: ⁠⁠https://physicians.utah.edu/echo/dermatology-primarycare⁠⁠Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

Hàng loạt ca ngộ độc botulinum tại Việt Nam thời gian gần đây gây tử vong hoặc liệt hoàn toàn cho các nạn nhân một lần nữa báo động thực trạng vệ sinh an toàn thực phẩm trong nước. Botulinum có mặt ở đâu, làm sao tránh?

Trong những ngày gần đây, ở rải rác một số địa phương đã xảy ra một số trường hợp bệnh nhân ngộ độc do độc tố botulinum. Người bệnh bị ngộ độc do độc tố botulinum có biểu hiện buồn nôn, nôn, chướng bụng, đau bụng, liệt theo trình tự - bắt đầu từ vùng đầu mặt cổ lan xuống hai tay, sau đó tới hai chân, liệt các cơ hô hấp. Liệt nặng có thể gây suy hô hấp là nguyên nhân gây tử vong. Làm thế nào để phòng chống ngộ độc botulinum? Chương trình “Sức khỏe trên hết” được phát sóng từ 13h30 – 14h00 các ngày thứ 2- thứ 4 – thứ 6 trong tuần trên Hà Nội FM tần số 90MHz.

Join me for a summary looking at the use of botox for deep bite management and bruxism. This was an interesting lecture by Dr Nan Hatch from Seattle, which was presented at this year's AAO 2023. She explored the use of Botox for masseter hypertrophy and the evidence around it. Masseter hypertrophy when combined with bruxism can result in: o  Long term changes in function o  Fixation breakages o  Orofacial pain, tmd, mobility How does it work? ·        Injection of neurotoxin into muscle ·        Temporary partial paralysis through chemical denervation ·        Most common Botulinum toxin or Botox ·        Mechanism of action o  Block acetylcholine (neuromuscular transmission) release. o  Also inhibit pain sensory neuron How to inject ·        Extra oral – use of facial landmarks ·        Intra-oral Use MRI / EMG guided injection   What are the effects ·        Anticipate change facial aesthetics ·        Greater facial contouring achieved with higher dosage Review Wu 2023 ·        Last up to 180 days ·        Greater complications with greater dosage   Anticipated change from botox ·        Treatment for masseteric hypertrophy o  35 units to masseter , two injections o  91% reported improvement headaches o  Duration 25 months   Decrease bite force Ahn 2007 ·        25 units to each massenteric muscle ·        Mean bite force 51kg /cm using bite block attached to a transducer o  Reduced to 30-36kg/cm for 8 weeks (29%-41% reduction) o  After 41kg after 12 weeks , no longer statistically significant ·        Significantly reduced bite force up to  8 weeks   Potential adverse effects ·        Chewing weakness ·        Sunken cheeks – high volume ·        Headaches ·        Sagging skin ·        Asymmetry ·        Paradoxical Bulging – miss masseter and affect other muscles ·        Distant spread of toxin ·        Speech disturbance ·        Muscle fiber atrophy 4-6 weeks, remover 4-6 weeks   Chemical denervation protocol ·        25 units per muscle, both masetter and temporalis ·        Interval 4-5 months and patient response ·        3-5 serial injections o  Some patients changes can be permanent

- Liên quan đến chùm ca bệnh ngộ độc Botulinum, Bệnh viện Chợ Rẫy vừa cho biết, 3 bệnh nhân đều phải thở máy. Tác giả : Kim Dung/VOV TP. HCM Chủ đề : ngộ độc, giò lụa --- Support this podcast: https://podcasters.spotify.com/pod/show/vov1tintuc/support

Os cremes com vitaminas fazem mesmo bem à pele? O colagénio rejuvenesce? O botox não faz mal? Os protetores solares, protegem mesmo? E o solário: faz bem?Pois é, se no episódio anterior lhe trouxemos a composição química de muito daquilo que ingerimos, desta vez vamos fazer uma viagem às profundezas da pele para perceber a química daquilo que colocamos neste que é o maior órgão do nosso corpo e o nosso primeiro (e enorme) escudo protetor. Inês Lopes Gonçalves entusiasmou-se com o tema e literalmente encheu Nuno Maulide com todas aquelas questões que todos nós (sim, mulheres e homens) gostaríamos de saber para ter uma pele mais bonita e, acima de tudo, mais saudável e com aspeto mais jovem. Até parece um anúncio de publicidade, mas não, não é... é Ciência.REFERÊNCIAS E LINKS ÚTEIS A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind StudyCollagen Products: Healthy or Hype?Why Science Says Hyaluronic Acid Is the Holy Grail to Wrinkle-Free, Youthful HydrationSunscreens and PhotoprotectionThe history of Botulinum toxin: from poison to beautyBIOS INÊS LOPES GONÇALVESInês Lopes Gonçalves é uma pessoa, função que acumula com as de radialista, locutora e apresentadora de televisão. Na rádio, é atualmente uma d'As Três da Manhã da Rádio Renascença, na televisão é anfitriã do talk show Traz Pr'a Frente, na RTP e RTP Memória. Fez rádio na Antena 3, foi apresentadora do 5 Para a Meia Noite na RTP, e desde 2017 que é uma das caras do Festival da canção. O seu percurso começou na informação como jornalista da Rádio Renascença, passou pela Sport TV, Canal Q, e colaborou com as revistas Time Out, Sábado e semanário Expresso.NUNO MAULIDENascido em Lisboa em 1979, é professor catedrático premiado e diretor do Instituto de Química Orgânica da Universidade de Viena. Foi eleito Cientista do Ano na Áustria, em 2018. Estudou Piano e Química em Lisboa, tendo realizado estadas de investigação nas Universidade Católica de Louvain, École Polytechnique em Paris e na Universidade de Stanford. Em 2009, assumiu o cargo de chefe de equipa no Instituto Max Planck para a Investigação sobre o Carvão, em Mülheim an der Ruhr (Alemanha).Desde 2013, ocupa a cátedra de Síntese Orgânica na Universidade de Viena. É autor do best-seller “Como se Transforma Ar em Pão” e de “Como Desvendar o Quebra-Cabeças da Origem da Vida?”, livros em que procura desmistificar a Química e explicar que ela – a Química – é omnipresente nas nossas vidas.

Botox, more formally called Botulinum toxin treatments, increased significantly in recent years, mostly marketed towards women. But there is a new trend that is being dubbed, "Bro-tox". Botox use in general rose 182% since 2020 and became wildly popular among men.

Những ngày qua, thông tin 10 người tại Quảng Nam được xác định ngộ độc Botulinum - chất độc thần kinh do cá chép muối chua khiến cộng đồng xôn xao. Chuyên gia y tế khuyến cáo, để phòng tránh ngộ độc Botulinum, người dân không sử dụng các món chế biến liên quan cá chép ủ chua. Chương trình “Sức khỏe trên hết” được phát sóng từ 13h30 – 14h00 các ngày thứ 2- thứ 4 – thứ 6 trong tuần trên Hà Nội FM tần số 90MHz.

- Liên quan tới vụ ngộ độc thực phẩm tại Quảng Nam sau khi ăn cá chép muối chua, đến nay 1 bệnh nhân đã tử vong, 1 người tiên lượng nặng. Các chuyên gia đã xác định nguyên nhân do vi khuẩn Botulinum có trong món cá chép muối chua. Trước vụ việc này, Cục An toàn thực phẩm 1 lần nữa khuyến cáo các biện pháp phòng tránh ngộ độc thực phẩm do vi khuẩn Botulinum sinh ra chất kịch độc này. Tác giả : Văn Hải/VOV1 Chủ đề : ngộ độc, cá chép --- Support this podcast: https://podcasters.spotify.com/pod/show/vov1tintuc/support

- Chỉ trong vòng 10 ngày, tại huyện miền núi Phước Sơn, tỉnh Quảng Nam xảy ra 10 trường hợp được xác định ngộ độc Botulinum. Đến nay có 1 bệnh nhân tử vong, 1 bệnh nhân tiên lượng nặng, nhiều người đang điều trị thở máy. Tác giả : Long Phi/VOV Miền Trung Chủ đề : quảng nam, ngộ độc --- Support this podcast: https://podcasters.spotify.com/pod/show/vov1tintuc/support

Mary sent me an email with a news article attached. The article said that 47% of people don't think that life will ever get back to normal after the Covid-19 pandemic. If you listen to the smallpox episodes, the Spanish flu episode and the polio episode, many of the same things happened that happened during the Covid pandemic. Schools were shut down, social distancing was a thing, people wore masks, they were encouraged to stay home, there was grocery delivery, there were vaccine mandates and there were travel cards. People had to prove that they were vaccinated before they could travel. During the polio epidemic, no one could leave New York City without proof that they had been vaccinated. As I sit here today, the Covid-19 pandemic has had relatively little long term affect on people. We're no longer wearing masks or social distancing. I haven't had to show my vaccination card in ages. What it comes down to is this: People as a rule are extremely short-sighted. They don't see past next week or next month. They think everything is going to last forever. Especially if that thing is something they view as negative. In truth, very few policies surrounding healthcare crises remain permanent. Our society is more concerned with war than public health. This is why 911 caused way more changes to society than Covid-19 ever will. At the end of the day, we're far more concerned about the cost of rebuilding infrastructure than we are with any sort of human destruction. Even though, human destruction is priceless. Cause of Death has a website! Come visit me at www.causeofdeath100secs.net. I also have an email address for the show at Jackie@causeofdeath100secs.net. Feel free to interact with me in either place! I'm going to be doing a special 100 Seconds to Midnight episode in Season 7. I'd like those of you who had experiences growing up during the Cold War to talk about those experiences. If you'd like to be a guest on the show, I can arrange that. If you'd rather just write your stories and send them in, that's fine, too. I can read them. These stories are important, and they need to be heard. Please participate if you can. You can reach me on the website at www.causeofdeath100secs.net or you can email me at Jackie@causeofdeath100secs.net. My Link Tree can be found at: https://linktr.ee/CauseofDeathpod Botulism Show Notes: https://emedicine.medscape.com/article/325451-overview#:~:text=Botulinum%20toxin%20acts%20by%20binding,toxin%20as%20a%20therapeutic%20tool. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856357/ https://pubmed.ncbi.nlm.nih.gov/8975111/ https://www.who.int/news-room/fact-sheets/detail/botulism https://go.drugbank.com/drugs/DB00083 https://www.mdpi.com/2072-6651/11/8/459 https://www.cdc.gov/botulism/definition.html https://www.health.gov.on.ca/en/public/publications/disease/botulism.aspx#:~:text=The%20recorded%20history%20of%20botulism,the%20Latin%20word%20for%20sausage. https://pubmed.ncbi.nlm.nih.gov/15027048/ https://www.nytimes.com/1982/04/28/garden/the-history-of-botulism.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496996/#:~:text=BoNTs%20are%20the%20most%20widely,migraine%20and%20for%20cosmetic%20use. https://www.cdc.gov/botulism/general.html http://assets.cambridge.org/97805216/94421/excerpt/9780521694421_excerpt.pdf Darkcast Network – Promo by Yours Truly Support my sponsors! It ensures that Sweet Pea can eat! This month's sponsors are FITAID and Codex. FITAID is a natural energy drink that contains several vitamins and minerals, but no artificial sweeteners. I've been drinking it after lunch when I need a little push to get me through the rest of my day at work. You can find FITAID products at https://www.drinkfitaid.com/causeofdeath for 40% off your first order! I'm really excited to discover Codex. I'm not very good to my skin, and as I age, it's starting to show. Codex has really helped my skin repair from the damage that I've done to it over the years. You can find the Codex products here: https://www.codexlabscorp.com/ Use promo code: CauseofDeath20 for 20% off your first order. The True Crime and Paranormal Podcast Festival is coming up from August 25th to the 27th in Austin, Texas and I'll be there representing another podcast that I'm heavily involved with. Stop by the True Consequences booth and meet Eric Carter-Landin and I! Get your tickets to the True Crime and Paranormal Podcast Festival at https://www.truecrimepodcastfestival.com Use promo code: Consequences for 15% off your ticket Podcast Promos: True Crime Fan Club Misty Mysteries Music: There is No Sequel by Philip Ayers You can reach me on: Instagram and FB: @CauseofDeath Twitter: @CauseofDeath10 Please don't forget to rate and review on any of the platforms found here: www.causeofdeath100secs.net You can support Cause of Death here: Subscribe on Apple Subscriptions Patreon: https://www.Patreon.com/JackieMoranty Ko-Fi: https://www.ko-fi.com/causeofdeathluckycharmsunplugg Merch can be found at: https://www.teepublic.com/user/causeofdeathluckycharmsunplugged Please share this podcast with everyone you know. Cause of Death is a proud member of the Darkcast Network. Find us at @darkcastnetwork on Twitter and @DarkcastNetwork on Facebook. I am also a proud member of the Ossa Collective Network. Cause of Death can be found on all major podcast platforms.

 Botulinum neurotoxin A (BoNT-A), often referred to as ‘Botox', is increasingly in cosmetic procedures. However, long-term use and high doses of BoNT-A may lead to immunoresistance, limiting its future therapeutic benefit. A panel of experts including Dr Mary Dingley, Cosmetic Medicine Centre, Australia, is addressing this emerging issue. They offer guidance to practitioners and promote a culture of open communication with patients about BoNT-A risks, to empower individuals to make a fully informed decision. Read more in Research Outreach Read their original article : https://www.doi.org/10.1097/GOX.0000000000004407

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528198v1?rss=1 Authors: Panzi, C., Lazo, O. M., Surana, S., Moretto, E., De La-Rocque, S., Schiavo, G. Abstract: Pathological tau aggregates propagate across functionally connected neuronal networks in human neurodegenerative pathologies, such as Alzheimer's disease. However, the mechanism underlying this process is poorly understood. Several studies have showed that tau release is dependent on neuronal activity and that pathological tau is found in the extracellular space in free form, as well as in the lumen of extracellular vesicles. We recently showed that metabotropic glutamate receptor activity and the SNAP25 integrity modulate the release of pathological tau from human and mouse synaptosomes. Here, we have leveraged botulinum neurotoxins (BoNTs), which impair neurotransmitter release by cleaving specific synaptic SNARE proteins, to dissect molecular mechanisms related to tau release at synapses. In particular, we have tested the effect of botulinum neurotoxin A (BoNT/A) on the synaptic release of tau in primary mouse neurons. Hippocampal neurons were grown in microfluidic chambers and transduced with lentiviruses expressing human tau (hTau). We found that neuronal stimulation significantly increases the release of mutant hTau, whereas wild-type hTau is unaffected. Importantly, BoNT/A blocks mutant hTau release, indicating that this process is modulated by SNAP25 in intact neurons. These results suggest that BoNTs are potent tools to study the spreading of pathological proteins in neurodegenerative diseases and will play a central role in identifying novel molecular targets for the development of therapeutic interventions to treat tauopathies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Hva er Migrene og hva er Hodepine? Og hva er egentlig forskjellen? Vi har besøk av Fysioterapeut Sven Birger Kloster som har jobbet hele yrkeslivet med disse problemstillingene i sin kliniske praksis og som av og til bruker litt andre metoder. Noen pasienter får livet ødelagt av Migrene og da er det viktig å tenke tverrfaglig mener Kloster.  Litteratur:  Clare P Herd, Claire L Tomlinson, Caroline Rick, W J Scotton, Julie Edwards, Natalie Ives. Botulinum toxins for the prevention of migraine in adults. Cochrane database of systematic reviews, June 2018 https://tidsskriftet.no/2008/11/oversiktsartikkel/menstruell-migrene  

Jag är jättesjuk. Så...ja, det är inte ett orörigt avsnitt. Patrick berättar om sina mäktiga elspartips och sen svarar vi på en fråga om surströmming och botulinum (om det nu är ett ord). Sen minns jag inte vad vi pratade om. Nu ska jag sova. Hej då.

Fresh or dry aromas? Cold or hot oil? And what about botulinum? Let's learn to make flavored extra virgin olive at home in a safe and simple manner.

In this episode, we review the high-yield topic of Clostridium botulinum from the Microbiology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

"Dr. Naoual Jaada Dermatologist in Rabat 10 years of experience 2, Moulay Abdelaziz Street. Place Moulay Ali Cherif. Hassan., Appt 7 - 2nd floor , Hassan , Angle Avenue patrice Lumumba , 200 m from CDG, tram stop Place El Joulane , Rabat, 10000, Morocco Our practice focuses on medical dermatology, " "--START AD- #TheMummichogblogOfMalta Amazon Top and Flash Deals(Affiliate Link - You will support our translations if you purchase through the following link) - https://amzn.to/3CqsdJH Compare all the top travel sites in just one search to find the best hotel deals at HotelsCombined - awarded world's best hotel price comparison site. (Affiliate Link - You will support our translations if you purchase through the following link) - https://www.hotelscombined.com/?a_aid=20558 “So whatever you wish that others would do to you, do also to them, for this is the Law and the Prophets."""" #Jesus #Catholic. Smooth Radio Malta is Malta's number one digital radio station, playing Your Relaxing Favourites - Smooth provides a ‘clutter free' mix, appealing to a core 35-59 audience offering soft adult contemporary classics. We operate a playlist of popular tracks which is updated on a regular basis. https://smooth.com.mt/listen/ Follow on Telegram: https://t.me/themummichogblogdotcom END AD---" "aesthetics and dermatological lasers; • Medical dermatology: inflammatory, infectious, venereal pathologies, skin cancer, systemic disease, etc. • Surgical dermatology (benign and malignant skin tumours) • Medical-surgical pathologies of the nails and hair • Aesthetic dermatology: correction and prevention of skin aging (peeling, hyaluronic acid, botulinum toxin, mesotherapy, lasers and skin remodeling system), scar correction and LED treatment. • Lasers: the practice is equipped with a cynosure-type depilatory laser, vascular laser, pin point laser for the treatment of mycoses (fungi) of the nails CO2 laser for the treatment of scars (post acne, post surgery, etc.) Working hours: office is open every day from Monday to Saturday and receives by appointment. Please allow a waiting time due to high demand. Medical procedures Aesthetic dermatology Botulinum toxin Surgical Dermatology Epilation laser Hyaluronic acid injection Dermatological Laser Laser dermatology Hair Removal Lasers Medical dermatology Peeling Vascular laser Education Specialist in Dermatology-Venerology Faculty of Monastir Diploma in aesthetic medicine and dermatological lasers University of Franche Comté - France https://www.dabadoc.com/ma/en/dermatologist/rabat/naoual-jaada-dermatologist-rabat "

There are a lot of myths surrounding Botox. But today, more and more people are turning to Botox to treat their skin and maintain a more youthful appearance. When administered in the right places by an experienced injector, Botox can be an effective part of a wrinkle-prevention strategy. So what information is true, what is false, and what should people know if they are considering trying Botox?The Skin Report is a podcast created to educate listeners on methods to improve skin health for people of all ethnicities and ages. This week, host Dr. Sethi busts popular Botox myths, discusses the history behind Botox, and explains how Botulinum toxins like Botox work to give patients a youthful appearance. She also shares the differences between Botox, Xeomin, and Dysport and provides advice for incorporating these neurotoxins into an anti-aging regime.Follow and DM a question for Dr. Sethi to answer on The Skin Report Podcast: RenewMDBeauty Instagram:https://www.instagram.com/renewmd_beauty/RenewMD Beauty Medical Spas, California:https://renewmdwellness.com/

This week we're diving into the world of neuromodulators. There's still a stigma that exists with botox along with many misconceptions. Neuromodulators (aka neurotoxins or BoTox) are an anti-wrinkle treatment that help soften fine lines and wrinkles. Botulinum toxin was first used medically and cosmetically in the late-1980s. Since then, several versions of botulinum toxin have been developed and FDA approved for use. These include Botox Cosmetic, Dysport, Xeomin, Jeuveau. Join us in today's episode as we talk about how neuromodulators work, who should avoid neuromodulators, what are some common side effects that can occur, and what are some misconceptions and evidence-based facts regarding neuromodulator treatment. Listen to the episode on Apple Podcasts, Spotify, Google Podcasts, Stitcher, TuneIn, or on your favorite podcast platform. Topics Covered: What are neuromodulators? How do neuromodulators work The different FDA-approved neuromodulators available Who should not get treated with neuromodulators Potential adverse reactions with neuromodulator treatment Myths vs facts about neuromodulators How we feel about neuromodulators as naturopathic doctors Connect With Us: Connect with Dr. Bryant Esquejo on Instagram, Youtube, and TikTok Interested in becoming a patient in Los Angeles? Schedule an appointment online here! Visit Dr. Bryant's website: http://www.drbryantesquejo.com Connect with Dr. Marilyn Merola on Instagram and TikTok Interested in an aesthetic treatment in San Diego? Schedule a free 15-min phone consultation online here! Struggling with adult acne? Check out Dr. Merola's holistic acne course Glow From Within here. Use code “HOLISTICBEAUTY10” for 10% off! Visit Dr. Merola's website: https://lucerenaturalmedicine.com Follow the Holistic Beauty Podcast on Instagram. Questions or topic requests for the podcast? Send an email to holisticbeautypodcast@gmail.com.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.01.506163v1?rss=1 Authors: Cottone, G., Chiodo, L., Maragliano, L., Popoff, M.-R., Rasetti-Escargueil, C., Lemichez, E., Malliavin, T. E. Abstract: Although the botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to the acidification of the interior of synaptic vesicles, and leading to the translocation of the BoNT catalytic domain into the neuronal cytosol. To investigate these conformational variations, homology modelling and atomistic simulations are combined to explore the internal dynamics of the subtypes BoNT/A1, the most-used in medical applications, and BoNT/E1, the most kinetically efficient. This first simulation study of di-chain BoNTs in closed and open states includes the effects of neutral and acidic pH. The conformational mobility is driven by domains displacements; the ganglioside binding site in the receptor binding domain, the translocation domain (HCNT) switch and the belt helix visit multiple conformations depending on the primary sequence and on the pH. Fluctuations of the belt helix are observed for closed conformations of the toxins and at acidic pH, and patches of more accessible residues appear in the same conditions in the core translocation domain HCNT. These findings suggest that during translocation, the larger mobility of belt could be transmitted to HCNT, leading to a favorable interaction of HCNT residues with the non-polar membrane environment. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

CME credits: 0.50 Valid until: 24-08-2023 Claim your CME credit at https://reachmd.com/programs/cme/update-on-botulinum-toxins-for-aesthetic-indications-duration-anatomy-and-other-patient-centric-considerations/13852/ The injection of botulinum toxin type A products can diminish unwanted facial wrinkles and improve appearance. Do you fully understand how to use these products? Tune in as Dr. Jason Bloom and Dr. Carolyn Jacob take us through the pharmacologic similarities, differences, and duration of effect for the 4 FDA-approved neuromodulators and demonstrate specific injection techniques for the masseter, platysma bands, “bunny lines,” and the glabellar complex.

CME credits: 0.50 Valid until: 24-08-2023 Claim your CME credit at https://reachmd.com/programs/cme/update-on-botulinum-toxins-for-aesthetic-indications-duration-anatomy-and-other-patient-centric-considerations/13852/ The injection of botulinum toxin type A products can diminish unwanted facial wrinkles and improve appearance. Do you fully understand how to use these products? Tune in as Dr. Jason Bloom and Dr. Carolyn Jacob take us through the pharmacologic similarities, differences, and duration of effect for the 4 FDA-approved neuromodulators and demonstrate specific injection techniques for the masseter, platysma bands, “bunny lines,” and the glabellar complex.

Thanks for tuning in to the Armor Men's Health Hour Podcast today, where we bring you the latest and greatest in urology care and the best urology humor out there.In this segment, Dr. Mistry and Donna Lee answer a listener who wants to know if "scrotox" could help him with his buried penis. Dr. Mistry explains that buried penis--a subject frequently discussed on the podcast--is as much a functional concern as it is a cosmetic one. In many cases, patients with a buried penis develop recurrent yeast infections from the inability to hold their penis and direct their urine stream. These patients can also can be difficult to catheterize. Another concern is lichen sclerosus, where patients have diseased skin around their penis or scrotum that must be removed and replaced with a skin graft. For this listener's buried penis, Dr. Mistry doesn't recommend scrotox. This term describes the use of the same Botulinum toxin used in Botox for the treatment of various issues with the scrotum. Scrotox can be used to relax the skin for men who have naturally tight scrotums. Sometimes, the issue isn't the scrotum itself, but rather the testicles squeezing too high into the abdomen. In this case, cremasteric relief surgery can help. If you or someone you know is suffering from buried penis, has a tight or uncomfortable scrotum, or feels like their testicles are being crushed, please give us a call today! This episode originally aired on 1.22.22. Don't forget to like, subscribe, and share us with a friend! As always, be well!Check our our award winning podcast!https://blog.feedspot.com/sex_therapy_podcasts/https://blog.feedspot.com/mens_health_podcasts/Dr. Mistry is a board-certified urologist and has been treating patients in the Austin and Greater Williamson County area since he started his private practice in 2007.We enjoy hearing from you! Email us at armormenshealth@gmail.com and we'll answer your question in an upcoming episode!Phone: (512) 238-0762Email: Armormenshealth@gmail.comWebsite: Armormenshealth.comOur Locations:Round Rock Office970 Hester's Crossing Road Suite 101 Round Rock, TX 78681South Austin Office6501 South Congress Suite 1-103 Austin, TX 78745Lakeline Office12505 Hymeadow Drive Suite 2C Austin, TX 78750Dripping Springs Office170 Benney Lane Suite 202 Dripping Springs, TX 78620

Manusia adalah makhluk yang paling gabut sedunia, bahkan salah satu racun biologis paling mematikan pun ditangan keisengan manusia dimanfaatkan sebagai agen untuk kecantikan. Racun tersebut tidak lain adalah botulinum toxin yang dihasilkan oleh bakteri bernama Clostridium botulinum. Bakteri ini pernah menjadi momok menakutkan pada manusia dan hingga saat ini sanggat diwaspadai karena kemampuannya mengkontaminasi bahan pangan yang diproses dalam pengalengan. #darwinquestpodcast kali ini akan membedah lebih dalam mengenai bakteri ini dan melihat potensi potensi karena kita adalah manusia, makhluk yang paling iseng dimuka bumi.

4EverYoung San Antonio Founder Dr. Carlos Wild talks about his clinic which provides a full range of medical and cosmetic treatments that will help you look and feel great. Born and raised in Miami, FL, Dr. Carlos Wild DNP, CRNA began his studies at University of South Florida where he received his BSN in Nursing and then completed his Masters of Science Degree in Nurse Anesthesia at Wolford College of Anesthesia. He continued his thirst for knowledge and attended Baylor College of Medicine receiving his Doctor Of Nurse Practice (DNP). He was the chief CRNA for the past 8 years while also running his Botox and filler company He specializes in using cutting-edge techniques for Dermal fillers and Botulinum toxins. Currently he took his Botox and filler company to the next level introducing a preventative medicine aspect into his new practice by starting up 4Ever young in San Antonio which focuses on hormone Replacement for men and women, IV infusions, Botox and filler, hydrafacials and more. They say what they offer is in their name. 4Ever Young is the embodiment of a powerful idea: that aging doesn't have to mean losing your quality of life.

Thanks for tuning in to the Armor Men's Health Hour Podcast today, where we bring you the latest and greatest in urology care and the best urology humor out there.In this segment, Dr. Mistry and Donna Lee answer a listener who wants to know if "scrotox" could help him with his buried penis. Dr. Mistry explains that buried penis--a subject frequently discussed on the podcast--is as much a functional concern as it is a cosmetic one. In many cases, patients with a buried penis develop recurrent yeast infections from the inability to hold their penis and direct their urine stream. These patients can also can be difficult to catheterize. Another concern is lichen sclerosus, where patients have diseased skin around their penis or scrotum that must be removed and replaced with a skin graft. For this listener's buried penis, Dr. Mistry doesn't recommend scrotox. This term describes the use of the same Botulinum toxin used in Botox for the treatment of various issues with the scrotum. Scrotox can be used to relax the skin for men who have naturally tight scrotums. Sometimes, the issue isn't the scrotum itself, but rather the testicles squeezing too high into the abdomen. In this case, cremasteric relief surgery can help. If you or someone you know is suffering from buried penis, has a tight or uncomfortable scrotum, or feels like their testicles are being crushed, please give us a call today!  If you enjoyed this episode, don't forget to like, subscribe, and share us with a friend! As always, be well!Check our our award winning podcast!https://blog.feedspot.com/sex_therapy_podcasts/https://blog.feedspot.com/mens_health_podcasts/Dr. Mistry is a board-certified urologist and has been treating patients in the Austin and Greater Williamson County area since he started his private practice in 2007.We enjoy hearing from you! Email us at armormenshealth@gmail.com and we'll answer your question in an upcoming episode!Phone: (512) 238-0762Email: Armormenshealth@gmail.comWebsite: Armormenshealth.comOur Locations:Round Rock Office970 Hester's Crossing Road Suite 101 Round Rock, TX 78681South Austin Office6501 South Congress Suite 1-103 Austin, TX 78745Lakeline Office12505 Hymeadow Drive Suite 2C Austin, TX 78750Dripping Springs Office170 Benney Lane Suite 202 Dripping Springs, TX 78620

每日英語跟讀 Ep.K275: The Art of Botox   Last spring, Botox rolled out a series of ads directed by filmmaker Errol Morris. Styled like very short documentary films, the ads featured Botox users — a widower, a single mother, a drag performer — telling touching, sad, ultimately redemptive anecdotes. In 2019, a typical Botox commercial pitched the product as a girlboss tonic that could infuse fantasy women with pluck as they slunk from boardroom to bar stool. Now it was being recast as a kind of truth serum, a tool of deep personal introspection. The mother gazed upon nostalgic photographs. The widower recalled her husband's eyes and wept. Though the subjects did not mention Botox, the camera regarded their restful foreheads with sympathy and implied that the procedure had a profound therapeutic effect. The tagline was: “Still you.” 今年春天，「保妥適」肉毒桿菌素推出一系列由電影製作人埃洛．莫里斯執導的廣告。這些廣告就像非常短的紀錄片，由鰥居者、單親媽媽和變裝皇后三位保妥適使用者，訴說動人、悲傷和最終具救贖力量的故事。2019年，一支典型的保妥適廣告把產品描繪成女強人的補品，能讓夢幻女子從董事會會議室溜到酒吧高腳凳時，賦予她們勇氣。現在保妥適被重新定位成一種能讓人吐露真相的藥，一種個人深刻自省的工具。這名母親凝視著舊照片。鰥居者回想起他丈夫的眼神而落淚。雖然這三人沒提到保妥適，但鏡頭拍攝她們平滑的額頭時帶著讚許意味，暗示這個療程有深刻療效。廣告語寫著「你還是你」（譯註：此為雙關語，也有「撫平你」的意思）。 Botulinum toxin is a poison that by some macabre coincidence both causes botulism and cures wrinkles. When injected at low doses into a crinkled forehead, it blocks nerve signals to muscles and smooths the skin atop them. Though there are several competing brands, Botox is the Kleenex of the category. It presents the kind of bargain one might strike with a nefarious sea witch: She will grant you eternal youth, but at the price of being able to move your face. 肉毒桿菌素是一種毒素，可怕的巧合是，它既能讓人肉毒桿菌中毒，又能除皺，低劑量注射到有皺紋的額頭上，能阻斷給肌肉的神經訊號，因而撫平肌肉上方的皮膚。雖然市面上有幾種競爭品牌，但保妥適是其中佼佼者。這種藥提供你可能和邪惡海巫達成的那類交易：她能讓你青春永駐，但價格之高足以讓你動容。 There was a moment when this trend was seen as a bad thing — for acting, for society, and especially, for women. A Botoxed face used to strike viewers as an uncanny spectacle, but uncanny spectacles fuel reality television and internet culture, and thanks to those ascendant forms, Botox has accumulated a gloss of campy pageantry, helping disarm cultural fears around its use. 以前有一陣子，用肉毒桿菌素除皺的趨勢被視為是不良風氣，對演藝人員、社會，尤其是女性都如此。打過肉毒桿菌素的臉曾經被觀眾認為是不自然的奇觀，但這種奇觀助長了電視實境秀和網路文化，多虧了這些日益興盛的類型，肉毒桿菌素累積了一種搞笑虛飾的光環，有助於消減使用上的文化恐懼。 Botox once suggested vanity, delusion and self-consciousness, but now it has fresh associations: with confidence, resilience, even authenticity, as the idea of “having work done” has come to be seen as a legitimate form of work. 肉毒桿菌素一度意味虛榮、錯覺和侷促不安，但現在給人新的聯想：自信、堅韌，甚至真實可靠，因為「進廠維修」已經被認為是正經事。 It strikes me that wrinkles on women are not only stigmatized because they make them seem old but because they make them look angry, sad, surprised, distressed — they make them look alive. Even as Botox has become a way station for women at risk of being catapulted from Hollywood, it presents as a vivid reminder of what has been lost. Female movie stars are no longer buried after a certain age; instead they are embalmed. The new Botox tagline is “Still you,” but it could be “Still here.” 在我看來，女人皺紋被汙名化的原因，不只是顯老，還會讓女人看似在生氣、難過、驚訝和焦慮，也就是讓女人看來活生生。即使肉毒桿菌素成了可能被逐出好萊塢女人的停靠站，仍鮮明地顯示了失落的東西。女性影星過了某個年紀不再被埋葬，而是做防腐處理。新的保妥適廣告語是「你還是你」，但其實可能是「你還在這裡」。Source article: https://udn.com/news/story/6904/5936772

In this episode, Dr. Grant Stevens discusses both the history and future of Botox with the Canadian eye doctor who is credited with spearheading its use in cosmetic applications, Dr. Jean Carruthers. Having used botulinum toxin as an ophthalmologist to treat blepharospasm (a condition that forces the eyes to involuntarily shut), Dr. Carruthers discovered that one of her patients loved what it did to eliminate wrinkles between the brows. She worked with her husband, a dermatologist, to pioneer the use of Botox for aesthetic purposes — and after becoming one of the first test cases herself, is proud to say that she "hasn't frowned since 1987." Find out what Dr. Carruthers predicts for the future of toxins in terms of new research, new applications, and new opportunities in this episode of The Technology of Beauty.

Skin wrinkles or furrows, such as on the forehead or around the eyes, are caused by the underlying muscles. Botox - or Botulinum toxin - is a medical chemical designed to temporarily weaken or relax those muscles, allowing the skin to be smoother. The smoothing effects of Botox treatments generally lasts 3-4 months. Lewisburg Plastic Surgery & Dermatology has extensive experience in the use of Botox. Still have questions? Email us at podcast@lewisburgplastic.com

Gram pozitif sporlu ve zorunlu anaerobik bir basil olan Clostridium botulinum tarafından üretilen bir nörotoksinin neden olduğu nadir ancak ölümcül bir nöroparalitik sendrom; Botulizm. Tarihsel Süreç Justinus Andreas Christian Kerner(en solda); Alman şair ve doktor, Uhland ve Gustav Schwab ile birlikte Swabian Şiir Okulu'nu kurdu. Ayrıca Botulizm semptomlarını tanımladı. Muhtemelen insanlık tarihinin başından beri bizimle birlikte, ancak hakkında elde edilen kayıtlar sınırlıdır. Belli dinsel tabular, yasaklar ile hakkında fikir sahibi olduğumuz bu etken ile ulaşılabilen en eski kaynak belki de Bizans İmparatoru VI. Leo'nun kan sosislerini yasaklaması olabilir. 1700'lü yıllarda Almanya'da bir kasabada yüzlerce kişinin sosis yedikten sonra gösterdiği zehirlenme bulguları ile hastalığa Latince sosis anlamına gelen "botellus" dan türetilen botulismus denmiştir. ​1​ Hastalık etkeni tam olarak açıklanamasa da 1817'de Dr. Justinus Christian Kerner tarafından botulizm semptomlar tanımlandı. Dr. Justinus Christian Kerner (1786-1862), Baden-Württemberg'de yaşayan romantik bir şair ve hekimdi . Bozulmuş sosis yedikten sonra ölen bölge halkı hakkındaki raporlarında botulinum toksininin etkilerini anlattı. Botulizm, ondan sonra "Kerner Hastalığı" olarak da adlandırıldı. ​2​ Etkenin Tanınması Bu tanımdan neredeyse 100 yıl sonra yine bir Avrupa kasabasında bu sefer cenaze yemeğinde yedikleri füme jambondan zehirlenen bir grup insan bilim dünyasının dikkatini çekmeyi başardı. 1897 yılında Ghent Üniversitesi'nde bakteriyoloji profesörü Emile Pierre van Ermengem etkenimizi Clostridium Botulinum tanımladı. ​3​ Sanılanın aksine "sosis" benzetmesini şeklinden dolayı değil; ilk ilişkilendirildiği besinlerden dolayı alan bakteri zamanla hayatımızda bir zehirden çok ilaç olarak da yer etmeye başladı.​2,4​ Prof. Émile van Ermengem Mikrobiyoloji C. botulinum zorunlu anaerob, sporlu, gram pozitif bir basildir. Her yerde bulunur ve tüm biyolojik yüzeylerinden kolayca izole edilir ve coğrafi fark gözetmeksizin dünya çapında toprak ve deniz tortularında bulunur.​5​ Yüksek ısıya, asit ve anaerop ortama dirençli sporlar gıdayı kontamine ettiğinde herhangi bir koku ya da renk değişikliği yapmazlar. Sporların kendisi ısıya dirençli iken toksinleri ısıya duyarlıdır. ​3​ Patogenez Botulinum toksini belki de bilinen en güçlü zehir ve en güçlü bakteriyel toksindir. Bir gram toksinin milyonda biri erişkin bir insanı, bir bardak ise tüm dünya nüfusunu yok edebilir düşüncesi ile II. Dünya Savaşı sırasında bir çok ülke bu toksini üretmiş; ancak hiçbiri kullanılmamıştır. ​1​ A'dan H'ye 8 farklı tip toksin sınıflandırılmıştır. Bunların bazıları insanda etkili iken bazıları kanatlı hayvanlarda bazıları ise insan dışı memelilerde etkilidir. ​6​ Etkisinin kesin mekanizması tam olarak anlaşılmamış olsa da, giderek artan kanıtlar, nörotoksinin presinaptik sinir terminalindeki spesifik reseptörlere bağlandığını göstermiştir. Toksin motor ve duyu nöronları dahil olmak üzere çizgili ve düz kaslar, gözyaşı, tükürük ve ter bezleri gibi birçok dokuyu hedefleyebilir. Botulinum toksininin hem uyarıcı hem de bloke edici etkileri olabilir ancak uyarıcı nöronlarda daha aktiftir. ​7​ Dopamin, serotonin, somatostatin, noradrenalin ve GABA dahil olmak üzere birçok bileşiğin salınımını engellediği gösterilmiştir. Nörotoksin boyutu nedeniyle kan beyin bariyerini geçememesi sinir sistemine ulaşmasında farklı yollar denemesine yol açmıştır. Yapılan araştırmalarda sistemik yayılma , aksonal retrograd veya anterograd taşıma yoluyla ulaşabileceğine dair kanıtlar artıyor. ​8​ Clostridium botulinum bacteria - Botulizm etkeni Toksinin kendisinin de kokusu veya tadı yoktur. Oral yolla vücuda alındığında, öncelikle mide ve ince bağırsak tarafından emilen toksin; mide asiditesi ve sindirim enzimleri tarafından bozulmaya karşı dirençlidir. Erişkinlerin aksine bebeklerde ise gastrointestinal sistem (GİS) florası yeterince gelişmemiştir.

A rapid review of neurotoxins for facial rejuvenation for the plastic surgery learner. In this episode we review:Botulinum toxin pharmacologyEvaluation and management of the facial rejuvenation patient seeking neurotoxin injectionsFeedback is always appreciated. Comments, questions, suggestions, or corrections can be sent to jakemarksmd@gmail.comReferences:Sundaram H, Signorini M, Liew S, et al. Global Aesthetics Consensus: Botulinum Toxin Type A--Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications. Plast Reconstr Surg. 2016;137(3):518e-529e.Noland ME, Lalonde DH, Yee GJ, Rohrich RJ. Current Uses of Botulinum Neurotoxins in Plastic Surgery. Plast Reconstr Surg. 2016;138(3):519e-530e.Walker TJ, Dayan SH. Comparison and overview of currently available neurotoxins. J Clin Aesthet Dermatol. 2014;7(2):31-39.

Botox isn't just for wrinkles any more! The FDA approved Botox in 2010 for treatment of chronic migraines.  Botox is a man made drug that comes from a toxin produced by the bacteria Clostridium botulinum. Botulinum toxin is a neurotoxin that is one of the most poisonous biological substances known.   How does Botox work? Botox enters the nerve endings at the injection sites and blocks the release of chemicals involved in pain. This essentially prevents pain signals from going to the brain, relieving migraines.  Visit our website www.thenursingpostpodcast.com for show notes and references in todays episode. Thanks for listening   

Microbiologia médica de Murray --- Send in a voice message: https://anchor.fm/las-poderosas-celulas-nk/message

Botox is a drug that weakens or paralyzes muscle. In small doses, it can reduce skin wrinkles and help treat some medical conditions. Botox injections are noted primarily for the ability to reduce the appearance of facial wrinkles. In this podcast, Dr. Shruti Marwah talks about botox, how it is injected, how it works and its benefits. Watch our other videos here: 1. What is Liposuction?| Who needs Liposuction https://www.youtube.com/watch?v=SjFU5fueTtg&t=6s 2. All About Liposuction Part-1 https://www.youtube.com/watch?v=00yOP-OYs9Y&t=14s 3. Liposuction Post-Operative Care, FAQs, Cryo Freezing https://www.youtube.com/watch?v=8c5M_mi0eBo&t=4s 4. High definition liposuction- assessing suitability https://www.youtube.com/watch?v=dCNuRfwTCD0&t=19s ➜To Book an Appointment:

Botulinum toxin and surgical intervention in children and adolescents with cerebral palsy: who, when and why do we treat?Jane Valentine, Sue-Anne Davidson, Natasha Bear, Eve Blair, Roslyn Ward, Ashleigh Thornton , Katherine Stannage, Linda Watson, David Forbes, Catherine Elliott PMID: 31415723DOI: 10.1080/09638288.2019.1644381AbstractIntroduction: This audit aimed to increase understanding of the long-term outcomes of evidence-based medical and surgical interventions to improve gross motor function in children and adolescents with Cerebral Palsy.Methods: Retrospective audit of a birth cohort (2000-2009) attending a tertiary service in Western Australia.Results: The cohort comprises 771 patients aged 8 to 17 years. Percentage of children receiving no Botulinum Toxin treatments in each Gross Motor Functional Classification System level was: I: 40%, II: 26%, III: 33%, IV: 28% and V: 46%. Of the total cohort, 53% of children received 4 or less Botulinum Toxin treatments and 3.7% received more than 20 treatments. Statistically significant difference in the rate of use of Botulinum Toxin pre and post-surgery (p < 0.001) was documented. Children levels IV and V had 5 times the odds of surgery compared to children levels I-III (Odds Ratio 5.2, 95% Confidence Interval 3.5 to 7.8, p < 0.001). For 578 (75%) of participants the last recorded level was the same as the first.Conclusion: This audit documents medical intervention by age and Gross Motor Functional Classification System level in a large cohort of children with cerebral palsy over time and confirms stability of the level in the majority.IMPLICATIONS FOR REHABILITATIONThe information from this audit may be of use in discussions with families regarding the timing and use of Botulinum toxin and surgical intervention for motor function in children and adolescents with Cerebral Palsy.Long term use of Botulinum Toxin within an integrated evidence-based clinical program is not associated with loss of gross motor function in the long term as evidenced by the maintenance of Gross Motor Functional Classification System stability.Keywords: Cerebral palsy; botulinum toxin; children; gross motor function classification; orthopedic surgery.

Triptans, CGRP inhibitors, Botulinum toxin injections, and when to refer to a headache specialist Dr. Shuhan Zhu interviewed by Dr. Dave Ho

Toxina botulínica é uma neurotoxina, produzida pela bactéria Clostridium botulinum e o subtipo A é o que usamos na clínica nos dias de hoje. Amplamente utilizada na área estética, há alguns anos já houve um aumento expressivo nas terapias com toxina botulínica na área de dor orofacial, sobretudo disfunção temporomandibular e também para bruxismo. Há alguns anos também, as pesquisas iniciais mostravam um efeito terapêutico porém com eficácia abaixo ou semelhante às técnicas já empregadas na área... nada muito animador. Será que algo mudou nos últimos tempos? Para conversar sobre isso eu convidei dois colegas queridos do bauru Orofacial Pain group: Giancarlo Canales e Rodrigo Poluha. Juntos eles lançaram um ebook, cujo link deixarei na descrição deste episódio, denominado Toxina Botulínica: aplicações além da estética. Prof. Dr. Giancarlo de la Torre Canales é peruano (hoje não teremos problemas em identificar quem é quem pela voz somente!), e mora no Brasil já há algum tempo. Fez mestrado e doutorado na UNICAMP, com a linha de pesquisa envolvendo toxina botulínica, e atualmente está como pós doutorando na FOB-USP junto com o professor Paulo Conti, desenvolvendo pesquisas envolvendo o uso da toxina botulínica. Prof. Dr. Rodrigo Lorenzi Poluha é paranaense, fez mestrado na Universidade Estadual de Maringá e doutorado na FOB-USP. Também vou falar com orgulho que foram meus alunos nos cursos do Bauru Orofacial Pain Group, sob coordenação, claro, do Prof. Paulo Conti. Link para ebook “Toxina Botulínica: aplicações além da estética”: https://txbalemdaestetica.wixsite.com/txbaade Link para artigos produzidos pelos convidados sobre o tema: - De la Torre Canales G, Alvarez-Pinzon N, Muñoz-Lora VRM, Vieira Peroni L, Farias Gomes A, Sánchez-Ayala A, Haiter-Neto F, Manfredini D, Rizzatti-Barbosa CM. Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial. Toxins (Basel). 2020 Jun 15;12(6):395. doi: 10.3390/toxins12060395 PMID: 32549196; PMCID: PMC7354430. - https://www.mdpi.com/resolver?pii=toxins12060395 - De la Torre Canales G, Bonjardim LR, Poluha RL, Carvalho Soares FF, Guarda-Nardini L, Conti PR, Manfredini D. Correlation Between Physical and Psychosocial Findings in a Population of Temporomandibular Disorder Patients. Int J Prosthodont. 2020 Mar/Apr;33(2):155-159. doi: 10.11607/ijp.5847. PMID: 32069339. - https://pubmed.ncbi.nlm.nih.gov/32069339/ - De la Torre Canales G, Poluha RL, Lora VM, Araújo Oliveira Ferreira DM, Stuginski-Barbosa J, Bonjardim LR, Cury AADB, Conti PCR. Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects? Clin Oral Investig. 2019 Sep;23(9):3411-3421. doi: 10.1007/s00784-019-03026-4. Epub 2019 Jul 24. PMID: 31342244.- https://pubmed.ncbi.nlm.nih.gov/31342244/ - De la Torre Canales G, Câmara-Souza MB, do Amaral CF, Garcia RC, Manfredini D. Is there enough evidence to use botulinum toxin injections for bruxism management? A systematic literature review. Clin Oral Investig. 2017 Apr;21(3):727-734. doi: 10.1007/s00784-017-2092-4. Epub 2017 Mar 2. PMID: 28255752. - https://pubmed.ncbi.nlm.nih.gov/28255752/ - Botulinum toxin-A injections as therapy for chronic painful post-traumatic trigeminal neuropathy: case report. - https://doi.org/10.14295/bds.2020.v23i1.1800 Fale comigo: @dtmdorofacial

There are several viral videos with millions of views referencing something called Antibody-Dependent Enhancement as a potential effect of COVID-19 vaccines or vaccines in general. Some make very bold claims and it's difficult to sort fact from fiction from hyperbole in these videos. On today's episode of Causes or Cures, Dr. Erin Stair will chat with Dr. Robert Malone about Antibody-Dependent Enhancement and how it relates to vaccine development. He will describe it in an easy-to-understand way, discuss the specifics of vaccine development, antibodies, COVID-19 and his thoughts on herd immunity and the future of the pandemic. Dr. Malone is a physician, vaccinologist, scientist and internationally recognized as one of the original inventors of "DNA Vaccination." He has done extensive research and clinical development in the areas of clinical trial design and vaccines, gene therapy, biodefense and immunology. In 2014, he built and led the initial team, under NewLink Genetics, that took the Canadian rVSVZEBOV-G Ebola vaccine from an abandoned vaccine candidate to a viable contender and eventually a successful vaccine for Ebola. He has worked with numerous high-level government and private organizations and has been involved in the design, development and oversight of over 40 Phase 1 Clinical trials, 20 Phase 2 clinical trials and 5 Phase 3 trials. His infectious disease pathogen advanced development oversight include HIV, Influenza, Plague, Anthrax, Tularemia, Tb, Ebola, Zika, Ricin toxin, Botulinum toxin and engineered pathogens. He has over 100 peer-reviewed papers, over 11 thousand citations and has sat on or served as chairperson on many NIAID and DoD study sections. You can learn more about his consulting firm and background here. Please keep in mind that this podcast is information only and never to be taken as medical or health advice. To contact Erin, do so through bloomingwellness.comTo read her short parody on the wellness industry, click here.To read Manic Kingdom, based on a true story, click here.To follow her on Instagram here.Or Facebook here.Or Twitter or YoutubeSubcribe to her newsletter here!

Botulinum toxin treatments in the upper face are a real 'bread and butter' treatment in most aesthetic clinicians' practice, but are you familiar enough with the anatomy to avoid side effects, whilst also maximising product efficiency?In this week's Aesthetics Mastery Show, Dr Tim takes us on an anatomical tour of the key muscles injected for upper-third Botox treatments, including the frontalis, corrugator, depressor supercilii, procerus, and orbicularis oculi.He shares why you should avoid paint-by-number injection techniques; the anatomy you need to know in order to avoid eyelid ptoses; how to get procerus toxin doses right; key tips if you struggle to locate muscles in the first place; and the answer to the crucial question of whether you can treat the frontalis without also injecting the corrugator.Dr Tim even shares a little-known tip to improve rhinoplasty results and longevity...using Botox.Let us know in the comments if you enjoyed this jam-packed episode, and don't forget to grab the incredibly helpful free download Dr Tim mentioned in the show: 26 Essential Injection Patterns For Botulinum Toxin - https://drtimpearce.com/resources/26-essential-injection-patterns-for-botulinum-toxin/Facebook: https://www.facebook.com/drtimpearce​Instagram: https://www.instagram.com/drtimpearce/​Website: https://drtimpearce.com/

Episode 37: Honey in MedicineSmoking cessation update. Honey in medicine. Uses, precautions, honey-related terms. Macroglossia and presbycusis are defined. Jokes about honey. Today is January 15, 2021. The American Thoracic Society approved a clinical practice guideline regarding pharmacologic treatment of tobacco dependence in adults. This guideline was published in May 2020 in the American Journal of Respiratory and Clinical Care Medicine. Seven recommendations about initial medications used in smoking cessation were given, five are STRONG recommendations and two are CONDITIONAL recommendations.Let’s start with the STRONG recommendations for tobacco-dependent adults in whom treatment is being initiated:Varenicline over a nicotine patch is recommended. Remarks: Be prepared to counsel your patients about the relative safety and efficacy of varenicline compared with a nicotine patch.Varenicline over bupropion is recommended.In patients who are not ready to quit smoking, treatment with varenicline rather than waiting until patients are ready to stop tobacco use is recommended.In patients with comorbid psychiatric conditions, including substance-use disorder, depression, anxiety, schizophrenia, and/or bipolar disorder, varenicline over a nicotine patch is recommended.For tobacco-dependent adults for whom treatment is being initiated with a controller, extended-duration (>12 weeks) over standard-duration (6–12 weeks) therapy is recommended. A controller is a medication with a delayed onset of effect that reduces the frequency and intensity of smoking (i.e. varenicline), whereas a reliever is a medication with acute effect to reduce cravings (i.e. nicotine gum). CONDITIONAL recommendations:Varenicline plus a nicotine patch over varenicline alone is suggested (conditional recommendation, low certainty in the estimated effects).Varenicline over electronic cigarettes is recommended. Remarks: serious adverse effects of e-cigarettes have been reported. The recommendation will be reevaluated if these reports continue.   Quotes about honey: You catch more flies with honey than with vinegar.No bees, no honey; no work, no money.Honey is sweet but bees sting.Be like the honey bee, anything it eats is clean, anything it drops is sweet, and the branch it sits upon does not break (Iman Ali, Pakistani actress)When you go in search of honey you must expect to be stung by bees (Joseph Joubert, French moralist)Life is the flower for which love is the honey (Victor Hugo, French poet)______________________________Claudia: Today we have a special episode to honor those with a sweet tooth. We will talk about the ultimate nature candy: honey. Yes, we will talk anything related to honey in medicine.But... what is honey? It is a sticky, sweet, clear yellowish-brown fluid made by bees. How? you might wonder; well they collect nectar in their honey stomach or what they call the “crop” and as you might be guessing they create honey by vomiting this digested nectar. Hector: Let’s start with honeycomb lung. Claudia: Honeycomb lung — This is something many medical students and residents might hear for the first time and think huh? Unfortunately hearing a patient has honeycomb lungs is not at all “sweet news.” Honeycomb lung is indicative of end-stage pulmonary fibrosis, and many disorders such as Idiopathic Pulmonary Fibrosis, sarcoidosis, hypersensitivity pneumonia, and eosinophilic granuloma can progress to end-stage fibrosis, but cannot be detected by pathologists at this stage of the disease. For that reason, biopsy of extensive honeycomb lung is not helpful and should be avoided.This Honey-comb appearance of lungs in CT scan has been found to be common in COVID-19.Hector: Yes, honeycombing fibrosis seems to follow ground-glass opacities(1) in COVID 19 patients. Honeycombing are small cystic spaces with irregular thickened walls made out of fibrous tissue. A friend told me this bold statement: “A CT scan is more sensitive than PCR to detect COVID-19”. That puzzled me, and I had to look it up. The American College of Radiology issued a statement saying that “viral testing remains the only specific method of diagnosis. Confirmation with the viral test is required, even if radiologic findings are suggestive of COVID-19 on CXR or CT. CT is reserved for hospitalized, symptomatic patients with specific clinical indications for CT.”(2) Do not use CT for COVID-19 diagnosis.Claudia: Next term is Honeymoon cystitis — Now why would you ruin a honeymoon which is supposed to be fun with the not so fun word cystitis.? Well because this uncomfortable infection is common in sexually active women and it makes sense that it can occur more often in newly-weds during a much-anticipated vacation. Hector: Recurrent urinary tract infections are a common problem in sexually active women. Anatomy is to blame of this problem. Sexual intercourse may cause local irritation of the urethral meatus and lead to cystitis ("honeymoon cystitis"). Claudia: Honey-colored crusts are present in Impetigo — This one is not as pretty as it sounds. Think of honey equals pus for this “honey colored crust”. Impetigo occurs most commonly on the face and can present with bullae, honey-colored crusts, erythema, edema, and exudate.Hector: A very very important topic is Honey in infants— Because it must not be given to them! And here is why.  Infant botulism occurs when C. Botulinum spores, which can live in honey, are ingested, colonize the GI tract, and release a wicked toxin. In the US, most cases are thought to result from ingestion of environmental dust and soil containing C. botulinum spores.  Claudia: The incidence of reported cases of infant botulism is highest in Utah, Pennsylvania, and California, states in which soil botulinum spore counts are high.  Hector: Did you know Utah is called the beehive state? Infant botulism has been associated with the ingestion of raw honey, but telling people “Don’t give honey to your babies” has not changed the incidence of infant botulism in the United States.[Insert joke here: Hey, a patient was admitted to the ICU because of botulism. Dr Saito: Did it take care of his wrinkles?Claudia: Honey has a high fructose content, and it is part of the FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols). A diet low in FODMAPs is recommended in patients with IBS. So, if you have IBS, honey is likely not the best sweetener for you. Now, let’s talk about Honeymoon phase of type 1 diabetes — A few weeks after the diagnosis and initiation of insulin therapy, a period of decreasing exogenous insulin (such as lispro or lantus) requirement occurs, commonly referred to as the "honeymoon" or remission phase of diabetes. During this period, the remaining functional beta cells in your pancreas secrete some endogenous insulin resulting in reduced exogenous requirement, so you give yourself less of the injectable insulin. Hector: I had a real case with this condition. He is a male patient on his mid 20s. He was diagnosed with diabetes let’s say in October 2019. He was admitted to the ICU because of DKA. His A1C was >11. He was sent home on insulin and then in January 2020 he decided to stop insulin “to see if he really needed it”. He came to me in July 2020, and I freaked out, I thought, “this guy’s sugar is going to be 500 and A1C will be in the double digits”. My surprise was that his insulin was 5.3! Claudia: Close monitoring of blood glucose is critical as hypoglycemic episodes are likely if the insulin is not adjusted appropriately. Some clues that the honeymoon phase in type 1 diabetes may be ending are: rising blood glucose levels, higher A1C, and increasing exogenous insulin need, that’s why monitoring is very important. The duration of this phase is variable and may last several months to several years. Hector: Let’s talk about folk medicine. This treatment has been known for centuries: Use of Honey in common cold – honey is an option for treating cough in children who are older than 1 year old with common cold symptoms. Honey can be given straight in 0.5 to 1 teaspoon or diluted in liquid like tea or juice. Corn syrup may be substituted if honey is not available. Honey has a modest beneficial effect on nocturnal cough and is unlikely to be harmful in children older than one year of age. Just as a reminder of what we covered earlier: Honey should be avoided in children younger than one year because of the risk of botulism.Claudia:  In a randomized trial, 300 children (one to five years of age) with upper respiratory infection and nocturnal cough were assigned to receive a single dose (10 g) of honey (eucalyptus, citrus, or labiatae) or placebo (a date extract similar to honey in appearance and taste) before bedtime; caregivers completed a symptom survey on the days before and after the intervention; 270 children completed the study. Symptoms improved in all children after the intervention. However, children who received honey had greater mean improvement in cough frequency (1.85 versus 1.00 points), severity (1.94 versus 0.99 points) and bothersomeness (2.16 versus 1.25 points) than those who received placebo. Hector: Adverse effects such as abdominal pain, nausea, vomiting occurred in five patients, approximately evenly distributed among each of the honey and the placebo groups. The findings of this trial were confirmed in a 2018 systematic review and meta-analysis of randomized trials (mean difference in cough frequency -1.62, 95% CI -3.02 to -0.22)[3]. Honey also reduced cough frequency compared with no treatment and diphenhydramine.Claudia: Given the relative safety and low cost of honey, the World Health Organization (WHO) and American Academy of Pediatrics (AAP) suggest it as a potential treatment for URI in young children who are older than one year. The American College of Chest Physicians suggests that honey is more effective than placebo for cough due to the common cold. Hector: Now we can talk about one of the favorite topics of Dr Tu (listen to our episode 6 about wound care), let’s talk about the use of Honey in wound care — Did you guys know that honey has been used since ancient times for the management of wounds? Honey has broad-spectrum antimicrobial activity due to its high osmolarity and high concentration of hydrogen peroxide.  Claudia: Medical-grade honey products are now available as a gel, paste, and impregnated into adhesive, alginate, and colloid dressings. Based upon the results of systematic reviews evaluating honey to aid healing in a variety of wounds, there are insufficient data to provide any recommendations for the routine use of honey for all wound types; specific wound types, such as burns, may benefit, whereas others, such as chronic venous ulcers and ingrown toenails after surgery, may not. Hector: Honey in chemoprophylaxis in partial-thickness burns — so this is an interesting one; as we mentioned a couple of minutes ago honey has a broad spectrum antimicrobial activity, remember? High osmolarity and hydrogen peroxide content. Partial thickness burns are prone to rapid bacterial colonization which can potentially become an invasive infection. It makes sense that we can use honey for partial thickness burns.Claudia: Anything more significant than sunburn or superficial burn since those do not need topical antimicrobials, normally, non-perfumed moisturizing cream is all that is needed. Silver Sulfadiazine can also be used but tends to delay healing. Modern hydrocolloid and silver impregnated dressings can be superior but surprise → honey “the ancient wound medicine” is still an effective treatment.Hector: Great, we talked about honeycomb lung, honeymoon cystitis, honey-colored crusts in impetigo, honey in infants, honeymoon phase of type 1 diabetes, honey in common cold, wound care and burns. Fun fact: Honey can be stored indefinitely. Jokes about Honeyby Katherine Schlaerth, Manuel Tu, Claudia Carranza, Gloria Villegas, and GracieWhy do bees have sticky hair? --> because they use honey combs.How do bees get to school? --> on the school buZZZWhat kind of bees make milk? --> BOO beesWhat do you call a bee that lives in America? --> a USBeeWhat does a bee sit on? --> it’s Bee-hind What kind of bees live in graveyards? --> zom-beesAnd remember, a bee that will not stop eating will eventually become a little Chuh-Bee!____________________________[Music] Speaking Medical: Macroglossiaby Xeng Xiong, MS4Your tongue can say a lot about your health. Today, I will go over the medical term macroglossia which means enlargement of the tongue. Symptoms associated with macroglossia may include drooling, speech impairment, difficulty eating, snoring and airway obstruction. Macroglossia is an uncommon anatomical abnormality and is usually a sign of an underlying condition. Some of the diseases associated with macroglossia are Down syndrome, hypothyroidism, tuberculosis, sarcoidosis, and angioedema. Examination often reveals an enlarged appearance on the lateral margins of the tongue caused by crowding against the teeth.  It is important to consider macroglossia as a sign of an underlying disorder and proceed with focused diagnostic testing, including possible biopsy. Treatment should be directed at the underlying disorder. Thanks for listening to macroglossia and have a Tongue-tastic day!____________________________Speaking Medical: PresbycusisHi, I’m Dr Rodriguez and I am presenting the Medical Word of the week. If you remember, in episode 28, we talked about presbyopia, so today I will teach you about presbycusis. Presbycusis is just one form of hearing loss that happens as you age. Presbycusis affects more than half of all adults by the time they reach the age of 75. Presbycusis is a progressive sensorineural hearing loss that mostly affects hearing of high-pitched sounds. That means that a person with presbycusis might have trouble hearing a bird chirping, phone ringing, crowded places but still be able to hear a truck rumbling.Multiple factors can influence the onset and severity of presbycusis, including white race, loud noise exposure, ototoxins (such as aminoglycosides), ear infections, smoking, hypertension, diabetes. In a patient with presbycusis, an audiogram will show decreased pure tone thresholds with relative preservation of word recognition. Even though hearing aids may offer some help, only a small percentage of patients actually receive effective treatment with amplification. Auditory rehabilitation, when available, is usually practiced in combination with hearing devices in presbycusis. For patients with severe presbycusis with poor response to conventional amplification, cochlear implantation offers hope to restore hearing.So, remember the medical word of the week: presbycusisAlyssa: Before you go, let me ask you a serious question. Many people told Beethoven that he would not make good music because he was deaf, but did he listen?____________________________[Music] Question of the week: Diabetes managementby Claudia Carranza, MD Q: What is the first treatment approach for type 2 DM? For example, for a patient who had polydipsia, polyuria for a few weeks and at your office had a random BG of 210. ________________________Now we conclude our episode number 37: “Honey in Medicine.” We started with an update on medications used for smoking cessation. Then, Dr Carranza and Dr Arreaza presented medical conditions related to the word “honey”, and they explained evidence-based uses of honey in medicine. Dr Rodriguez defined presbycusis, and future Dr Xiong explained macroglossia. You may ask, “what does smoking, honey, deafness, and big tongues have in common?” The answer is: Family Medicine. Remember, the question of the week is: What is the first treatment approach for type 2 diabetes? The listener with the best answer will receive a prize! Send you answer to our email: rbresidency@clinicasierravista.org.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RBresidency@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created with educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Claudia Carranza, Steven Saito, Alyssa Der Mugrdechian, Yodaisy Rodriguez, Xeng Xiong, Katherine Schlaerth, Gloria Villegas, Manuel Tu, and Gracie Pena. Audio edition: Suraj Amrutia. See you next week!_____________________References:Leone, Frank T.; Zhang, Yuqing; Evers-Casey, Sarah, and col., Initiating Pharmacologic Treatment in Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline,  American Journal of Respiratory and Critical Care Medicine, American Thoracic Society,  https://doi.org/10.1164/rccm.202005-1982ST Combet M, Pavot A, Savale L, Humbert M, Monnet X. Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19. Eur Respir J. 2020;56(2):2001808. Published 2020 Aug 27. doi:10.1183/13993003.01808-2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338404/ ACR Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection, American College of Radiology, https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection, accessed on Jan 13, 2021.  Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018 Apr 10;4(4):CD007094. doi: 10.1002/14651858.CD007094.pub5. PMID: 29633783; PMCID: PMC6513626. https://pubmed.ncbi.nlm.nih.gov/29633783/

Interview with Roopa Rajan, MD, DM, author of Assessment of Botulinum Neurotoxin Injection for Dystonic Hand Tremor: A Randomized Clinical Trial

Interview with Roopa Rajan, MD, DM, author of Assessment of Botulinum Neurotoxin Injection for Dystonic Hand Tremor: A Randomized Clinical Trial

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.29.319145v1?rss=1 Authors: Dyer, R. P., Isoda, H. M., Salcedo, G. S., Speciale, G., Fletcher, M. H., Le, L. Q., Liu, Y., Malik, S. Z., Vazquez-Cintron, E. J., Chu, A. C., Rupp, D. C., Jacky, B., Nguyen, T. T., Steward, L. E., Majumdar, S., Brideau-Andersen, A. D., Weiss, G. A. Abstract: The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the substrate specificity of BoNT/A's protease domain (LC/A) could expand its therapeutic applications; however, LC/A's extended substrate recognition (approx. 60 residues) challenges conventional approaches. We report a directed evolution method for retargeting LC/A's substrate and retaining its exquisite specificity. The resultant eight-mutation LC/A (omLC/A) has improved cleavage specificity and catalytic efficiency (1300- and 120-fold, respectively) for SNAP23 versus SNAP25 compared to a previously reported LC/A variant. Importantly, the BoNT/A holotoxin equipped with omLC/A infiltrates neurons and retains its SNAP23 activity. The identification of substrate control loops outside BoNT/A's active site could guide the design of improved BoNT proteases and inhibitors. Copy rights belong to original authors. Visit the link for more info

MẬT ONG KO NGUỒN GỐC NHIỀU KHẢ NĂNG CHỨA BOTULINUM GIỐNG PATE MINH CHAY

Yêu cầu trên được đưa ra sau khi xảy ra một số trường hợp ngộ độc thực phẩm do độc tố Botulinum liên quan đến thực phẩm pa tê chay (PATE MINH CHAY) tại một số tỉnh, thành trong cả nước, trong những ngày gần đây. Hosted on Acast. See acast.com/privacy for more information.

Tinh tế radio 31/8: Trên tay iPhone 12 dummy; C. botulinum và ngộ độc thịt; Tối nay có livestream

COVID-19 has had profound effects on the financial stability of academic institutions, resident training, and patient care. Candrice Heath, MD (@DrCandriceHeath) talks to Erin Boh, MD, and Dirk Elston, MD, about emergency response plans in the academic setting as well as how institutions have been using teledermatology and managing resident education. “Our institution is doing quite well because we’ve actually jumped headlong and feetfirst into COVID research. . . . Our research dollars have increased double percentwise because of that," Dr. Boh said. *  *  * This week in dermatology news: Cutaneous clues linked to COVID-19 coagulation risk: https://bit.ly/31Ik4Ne Research letter: https://bit.ly/3kCnWIn Skin manifestations of COVID-19: https://bit.ly/2XUonnL Study highlights potential advantages of tape strips over biopsy: https://bit.ly/33TTZxi Original source: https://bit.ly/30R4WOm Botulinum toxin associated with antidepressant effects across indications, injection sites: https://bit.ly/2XVMd2m Original source: https://go.nature.com/3kGM38y *  *  * Hosts: Nick Andrews; Candrice R. Heath, MD (Temple University Hospital, Philadelphia) Guests: Erin Boh, MD, PhD (Tulane University, New Orleans); Dirk M. Elston, MD (Medical University of South Carolina, Charleston) Disclosures: Dr. Heath, Dr. Boh, and Dr. Elston report no conflicts of interest. Show notes by: Alicia Sonners, Melissa Sears *  *  * You can find more of our podcasts at http://www.mdedge.com/podcasts       Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeDerm  

In this episode, we are discussing the newly popular PDO threads and your potential rejuvenation. First,... what are PDO threads? Threads have come a long way from the surgical gold threads to the new PDO dissolving threads. These PDO threads are used predominantly for tissue/ fatty descent of the face. Areas that are no longer or not capable of rejuvenation by regular means (Botulinum toxins, Fillers, and Bio-stimulators) would require some thread lifting to counteract the descent and laxity of the face. Don,t be afraid to try new treatments, especially from a trusted licensed injector. What are the safety outcomes? What happens when the threads dissolve? All these and more. Subscribe, Follow, Ask! I,m here.

Botox zur Faltenbehandlung ist populär, allerdings solltest Du wissen, worauf es bei einer Behandlung ankommt und worauf Du unbedingt achten solltest. Nachdem wir in der letzten Episode eher allgemein über Botox gesprochen haben, beantworte ich in dieser Folge (fast) alle wichtigen Fragen rund um eine ästhetische Botox-Behandlung. Viel Spaß!   Deutsche Gesellschaft für ästhetische Botulinumtoxin-Therapie (DGBT):   Über Dr. Niels Freitag: https://www.nielsfreitag.com   Privatpraxis für Ästhetische Medizin: http://www.praxis-drfreitag.de/   Kosmetikstudio: http://www.kosmetikstudio-drfreitag.de/   Socialmedia: https://www.youtube.com/drmednielsfreitag https://www.facebook.com/dr.niels.freitag/ https://www.instagram.com/dr.niels.freitag/  

Today we'll cover two Gram-positive bacilli from the Clostridium genus. One causes spastic paralysis and the other causes flaccid paralysis. High-yield, board-relevant information and two board-style practice questions. --- Send in a voice message: https://anchor.fm/bradleysmicroboardreview/message Support this podcast: https://anchor.fm/bradleysmicroboardreview/support

Episode 013: An action plan for getting the most out of The PTSD Blueprint. See, this is the last podcast in The PTSD Blueprint and now you know just how complex PTSD issues can be. In the last episode you can see how Endocannabinoid Receptor Deficiency burns out the body system and makes people susceptible to suffering the symptoms. In this episode, we'll look at the toxins, nutrition, exercise and environmental stressors that can all affect PTSD. The worst-case scenario occurs when an increasing number of dimensions are struggling at the same time. For example, physical pain, anxiety, insomnia, loneliness, and guilt. Combinations of symptoms like this affect the physical, mental, spiritual, and emotional dimensions. The PTSD survivor feels like there is no where they can turn to get relief. Now that you've gotten through The PTSD Blueprint, you can see how puzzling it is for people. We should probably marvel that our PTSD therapies work at all. That they do work, highlights only how resilient people are and not necessarily how bright psychologists and psychiatrists have treated trauma wounds over the years. The PTSD Detox Now that you've listened to the first 13 podcasts, downloaded The PTSD Blueprint, you're ready to put it into action using the PTSD Academy 100-Day Detox Challenge. The premise is simple, take specific actions in each of the four dimensions of self: physical, mental, spiritual, and emotional. Imagine how good you will feel if you not only exercise your physical body for 100 days in a row, but also your mind, emotions, and spirit. Rules for the 100-Day Challenge Do at least one item for each of the 4 categories per day, for 100 days. Put your own spin on it - after all, it's your plan to get better. After 100 exercise repetitions per day for 100 days, you will have done 10,000 repetitions! Toxins in the food supply Our bodies are made to be integrated with nature, not inside climate-controlled, man-made boxes with unnatural light that doesn't have the full spectrum. It's been well documented that the food supply has artificial, man-made ingredients that are not recognized or are downright toxic to the gut. This triggers an inflammatory response that directly affects brain health and mental health problems. When health nutrition is supplied, depression improves, so I would expect it to also help PTSD. Water and food are packaged, processed, and delivered while in contact with plastic. Plastic leaches out toxic chemicals, worse under heat. Bisphenol-A (BPA) is one of the chemicals that come off the plastic. This is why people say don't drink water out of plastic bottles that have set out in the heat. Many companies are now offering BPA-free plastics, but BPA is only one of many chemicals that leach off the plastic. Dental root canals can mimic PTSD symptoms I watched a scary documentary called Root Cause that made a convincing case about the danger of leaving dead tooth tissue inside the root that gets left behind. Botulinum toxin, the same toxin that is injected to make nerves die and causes rigor mortis, gets released slowly from the old, dead nerve root tissue. Just like medications and food preservatives, toxins entering the body are monitored, arrested, and destroyed by the immune system. The complexity of the biochemistry of an inflammatory response leads to what can be thought of as a final common pathway for disease: inflammation, swelling, weight gain, decreased immune response with increased propensity to get infections, insomnia from the cortisol, cognitive clouding, and increased perception of pain. When you start feeling like this it becomes very difficult to maintain self-care, so the medical problems can really start piling up.   Environmental stressors that impact PTSD Our earth has become toxic. Many believe we are witnessing our last days on earth as we know it. Our food and water are contaminated. Oh, and it turns out that cell phone signals are actually bad for you and,

Clostridium botulinum

Michelle Magid, MD, conducts a Masterclass lecture on botulinum toxin for depression from the Psychopharmacology Update in Cincinnati. The meeting was sponsored by Global Academy for Medical Education and Current Psychiatry. Dr. Magid is associate professor University of Texas in Austin, and associate professor of Texas A&M University in College Station. She disclosed serving as a speaker for Ipsen, maker of Dysport (abobotulinumtoxinA, or ABO), and as a consultant for Allergan, maker of Botox (onabotulinumtoxinA). *  *  *   Help us make this podcast better! Please take this short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019  *  *  *   This week in psychiatry: Conduct disorder in girls gets overdue research attention by Bruce Jancin The physiological and emotion-procession abnormalities that underpin conduct disorder in teen girls are essentially the same as in teen boys. however, the clinical presentation of conduct disorder in the two groups is often different.  What we know about botulinum toxin Botulinum toxin is the product of Clostridium botulinum. The neurotoxin inhibits the release of acetylcholine, resulting in flaccid muscle relaxation. Its clinical use started in 1989 to treat strabismus (crossed eyes) and blepharospasm, a dystonic reaction in the eyes. Currently, botulinum is a Food and Drug Administration–approved treatment of chronic migraine in adults. For use in depression, 30-40 units of botulinum toxin is injected into the glabellar region of the face (the forehead). A purported mechanism of action of botulism for depression includes the “facial feedback hypothesis,” in which the activation of muscles of facial expression, consciously or unconsciously, influences emotions. Botulinum toxin for depression is an off-label treatment with four case series, five randomized, controlled studies, and a phase 2 trial by supported by Allergan. New findings on use of botulinum toxin for depression  Magid and colleagues completed a pooled analysis of three randomized, controlled trials totaling 134 patients. Fifty-nine people were included in the botulinum toxin intervention group with a Beck Depression Inventory (BDI) score of 29, and 75 individuals in the placebo group with BDI of 26. In each group, 64% of patients were continued on other medications for depression, and the groups had similar histories of long-standing depression. In the botulinum toxin group, 52% had a response to the intervention, with an at least 50% reduction in their baseline depression scores, compared with a limited response in the placebo group. In the pooled analysis, Dr. Magid’s group analyzed whether the cosmetic effect of botulinum toxin could be a confounding factor. The investigators ruled out that effect by using a subanalysis to evaluate whether the decrease in wrinkles correlated with decrease in depression, and it did not. Allergan moved forward with a phase 2 proof-of-concept trial; the results were mixed. The endpoint was response rate in Montgomery-Åsberg Depression Rating Scale (MADRS) at week 6. With a 30-unit Botox dose, there was a statistically significant decrease in MADRS at week 9, but not at week 6. There was no statistically significant divergence in data between the placebo and intervention group with the 50-unit dose. Given the response rate at week 9, Allergan is proceeding with a phase 3 trial. The cost is about $400 per treatment, and the treatment is given three to four times a year, which makes the cost comparable to that of other psychopharmacologic treatments. Adverse events are mild and include headache and local site irritation. In the current studies, botulinum treatment has been used as both monotherapy and augmentation; however, there are not enough data to know whether one is more effective than the other. In conclusion, burgeoning psychopharmacology research on treatments such as botulinum toxin for depression and novel medications, such as esketamine and brexanolone, broaden our understanding of the etiology of depression. This research is generating novel modes of treatment that will help more patients with refractory illness. References Magid M et al. Treating depression with botulinum toxin: A pooled analysis of randomized controlled trials. Psychopharmacology. 2015 Sep;48(6):205-10. Magid M et al. Treatment of major depressive disorder using botulinum toxin: A 24-week randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2014 Aug;75(8):837-44.  *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgePsych  

In the early 1800s, a German doctor discovered a specific bacterium in food that was leading to many illnesses in the area. By the early 1900s, the discovery had turned into a public health hazard, and it was identified as one of the most dangerous contagions in the world. By the early 2000s, people were paying to have this toxin injected into their bodies.Proverbs rhetorically asks us, “Can a man scoop fire into his lap without his clothes being burned? Can a man walk on hot coals without his feet being scorched?” (6:27-28)Researchers and scientists discovered a beneficial use for the toxin that centuries earlier led to many deaths, and Botulinum toxin, better known as Botox, is used today in the aid of everything from eye muscle disorders to migraine headaches But just as we wouldn’t inject an unknown poison into our bodies, we have to be careful with what we feed ourselves spiritually. Flee from sin. Call on the name of the Lord who saves. And set your eyes on Jesus, the founder and perfecter of our faith.

In this episode, Sarah and Stacy breakdown Botox - what is it, what are the side effects, what are the adverse reactions, and what does the science tell us about the impact of this procedure. Our hosts bring this thorough scientific discussion full circle and share their personal feelings towards this procedure and how they personally handle skin health. Click here to listen in iTunes If you enjoy the show, please review it in iTunes! The Paleo View (TPV), Episode 349: Must-Know Botox Info (0:41) Intro It feels like an eternity to Sarah since she last had the chance to talk to Stacy, which it basically has been since they prerecorded the latest episodes while Stacy was traveling Stacy will share about her travels on next week's episode, but she is still processing it all The trip was wonderful, and she has shared some updates via social media, but it was a family trip with many experiences and she is determining what all she wants to share and all the feels One of the things that happened while Stacy was traveling; she got a massage and it put her back in a flair Stacy did really well up until that point, which was 10 days into the trip. And she is excited to share that the first thing she did when she got home was put her Joovv to use and has been doing red light therapy on her back since returning and feeling the benefits of her Joovv (this week's episode sponsor!) While we will cover Joovv in greater detail later in the show, if you are ready to get all the details on them now, head over to joovv.com/thepaleoview, and learn all about our favorite biohack Sarah is gearing up for Paleo Fx, she leaves tomorrow - so by the show airs she will be on a stage sticking it to the man, which is what she typically does there She often finds herself in the myth-busting role at these events, but doesn't actually like confrontation and wishes she could simply have everyone read the same scientific studies she is referring to It is way easier to be on a soapbox on Skype with Stacy than it is to be in front of a few hundred or a thousand people During Sarah's workshop in February talking about different types of scientific studies became really thematic, and how do you evaluate science and what do you look for and how do you detect pseudo-science - are topics that people would love to know more about Sarah is trying to figure out how to condense these topics for the average person, as she recognizes the need for those in the health field to have access to this information Stacy notes the importance of learning not just how to read these scientific studies, but how to use and apply the information in life without bias To be able to look at the science and let that drive justification or not as to why something is improving your health or not, which is where the topic for this week's episode came from What has been interesting for Stacy as a member of this non-toxic living community is the questions she receives around the use of Botox, among many other things, and where these injections fall in the healthy living spectrum Stacy strives to help people find healthy solutions and Botox is off her list - through even just her preliminary research she has found that it is not for her So on this week's episode, she wants to answer this question from a scientific perspective Whether or not Botox is right for someone is ultimately a personal decision, but Stacy and Sarah's aim for this episode is to talk about the science and why both Stacy and Sarah would or would not make such a decision This is not a judgment show; we want to make everyone feel comfortable when they listen to the show Today's discussion is information driven and we are letting the science speak for itself that is how Stacy and Sarah are driving their decisions If Botox was safe Stacy would go out and have it done in a heartbeat Sarah wants to note that there is a lot of pressure for social influencers to look a certain way, to appear young, healthy and vibrant is a part of the credentials Botox is a fast solution and Sarah understands the allure of it and why many are driven to use it it seems like an effective way to get the results we are looking for What Stacy has personally done, in addition to more natural solutions (infrared - Joovv), is changed who is influencing her life so that she is no longer seeing only seeing a barrage of perfection, but is instead seeing people who inspire her to be herself and be real and be natural If a listener is feeling the pressure of something, Stacy suggests looking into where that pressure is coming from and how you can reduce that pressure You may not even realize where all the pressure is coming from - but ask what can you do to control it and empower yourself to value who you are and how you look Find someone who tells you that your flaws are beautiful (20:59) And Now the Science Botulinum toxin is what Botox is Botox was a carefully considered shortening of the name of a neurotoxic protein The way that it causes botulism is by preventing the release of a neurotransmitter It causes what is called flaccid paralysis, which is paralysis by muscle relaxation It is the most lethal toxin known to man A lethal dose of botulinum toxin is as low as one or two nanograms per kilogram body weight when injected into your muscle or into your bloodstream, which is an incredibly small amount of the toxin It was studied originally in research because of this interest in the ability for it to block nerves that control muscles to cause muscle relaxation There are of course medical uses where botox does have therapeutic benefit, but that is a different evaluation all together However, it is worth noting as we talk about the undesirable side effects that the therapeutic doses tend to be even higher than the cosmetic doses and so the risk of an adverse effect is much higher in the therapeutic applications So if you are dealing with one of these situations where botox may have therapeutic benefits Sarah highly recommend having a very thorough conversation with your medical provider and really understanding what all your options are and what to look for with adverse effects There are very few scientific studies that look at the effects of Botox beyond two years and very few look at the effects of multiple injections What Stacy finds interesting is all of the rebrandings of Botox, and these products aren't different they are just marketed differently So be aware of the Botox, look at the warning labels, and do the research (27:59) Side Effects and Adverse Reactions A side effect is a minor complaint that happens on the side that basically resolves on its own Whereas an adverser effect is a major problem, potentially life-threatening that requires medical intervention Both are known to happen with Botox use These are a list of the side effects: drooping eyelids uneven eyebrows a crooked smile, which can lead to drooling asymmetry swelling bruising, discomfort and inflammation in the injection area systemic effects include: fatigue headache neck pain double vision dry eyes or excessive tearing fever and chills allergic reactions (hives, rashes, asthma, etc.) Adverse reactions include: difficulty speaking difficulty swallowing severe muscle weakness loss of bladder control vision problems Then there is a gray area of in between where some studies qualify certain reactions as adverse whereas other studies define the same reactions as side effects Like vomiting, heart function, lung function, etc.; based on how severe they are they get put on either end of the spectrum What Sarah finds kind of scary is that very few studies have looked at repeated treatments and long-term effects, especially beyond two years It is estimated that there are 5 million Botox treatments a year globally and that it is a 2 billion dollars a year business right now - and this is just looking at the cosmetic use There was one study published in 2005 that looked at participants over the course of 12 years who were using Botox for both therapeutic and cosmetic reasons The study found that during the study period there were 20 cases of adverse effects in 16 of the participants, about a 1/3 of the participants This included: difficulty swallowing, droopy eyelids, neck weakness, nausea, vomiting, blurred vision, general or marked weakness, difficulty chewing, hoarseness, swelling, difficulty speaking and heart palpitations A 2015 review of the research found that there have been very few long-term studies and the risk of adverse effects seems to really increase after the 10th or 11th injection For most people this is three to four years out of doing this regularly This hasn't been studied rigorously, despite the wide use of Botox Around 2015/2016 there was a spike in studies showing problematic effects and it started to hit the news that Botox might be as safe as we think it is There have only been a handful of studies in the past few years that build on that In the grand scheme of things though, it takes three to four years to build on these ideas and complete the research, so we are essentially waiting on these research labs to come out with their follow up papers (30:30) The Latest Findings In this timeframe, 2015/2016, there were a couple of papers that showed Botox actually travels through neurons So up until 2015, it was believed that Botox could defuse a short way through the cells Now it is known that it migrates, which explains how you could get full body weakness from a Botox injections This is the explanation for these systemic adverse effects These studies haven't hit the general body of knowledge around Botox The studies Sarah referenced: Long-term botulinum toxin efficacy, safety, and immunogenicity The 2015 findings Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin Botulinum neurotoxin type A induces TLR2-mediated inflammatory responses in macrophages A 2009 study titled, “The link between facial feedback and neural activity within central circuitries of emotion--new insights from botulinum toxin-induced denervation of frown muscles” A 2010 study titled, “Cosmetic use of botulinum toxin-A affects processing of emotional language" A 2011 study titled, “Embodied Emotion Perception” 2014 study titled, “Botulinum toxin-induced facial muscle paralysis affects amygdala responses to the perception of emotional expressions: preliminary findings from an A-B-A design" A 2014 study titled, “Altered cortical activation from the hand after facial botulinum toxin treatment” 2016 study titled, “Deeper than skin deep – The effect of botulinum toxin-A on emotion processing” In addition to the impact that Botox has on the nervous system, there is also direct immune effects, which also has some concerning implications There are only a couple of studies that look at this, but Botox is basically causing an incredibly intense inflammatory response As Sarah was researching this and feeling frustrated at the lack of long-term studies, she thought that this would have been a component that would have been needed for FDA approval Sarah hit on this entire other field of research that looks at the impact of Botox of mental and emotional health An important piece to note from the latest research is that Botox is only 80% effective, so 20% of people who get Botox (whether used for therapeutic or cosmetic use) and don't actually get the benefits of Botox There is a collection of studies showing that Botox blunts emotional responses and emotional experiences Stacy's mind has been completely blown by these findings The idea of not being able to pick up on emotional queues would devastate Stacy There are 8 to 10 studies that have looked at these emotional and mental effects, so it has been fairly thoroughly looked at and it is showing the impact that Botox has on the brain stem (47:59) Closing Thoughts on Botox On a side, Sarah highly recommends the book Brainstorm There is also the potential for side effects on memory and feeling emotions in general The idea of giving up something for the benefit of another thing, in this case, the aesthetics, and does that really make the person happy In Stacy's experience, she has never known anyone who had a cosmetic procedure that said, and now I am complete and fulfilled and everything is great Stacy often hears from people that on the other side of that change you make, that it doesn't actually solve the problem, it just highlights another for you There are so many articles out there about people who become addicted to cosmetic procedures Society has come to a point where we have lost the ability to step back and look at more than just the wrinkle, and this case, all the many other things impacted by one procedure The health consequences are very problematic for Stacy, but the inflammatory response and the mental and emotional issues that come along with it make it all the more horrifying to her Sarah thinks that its this collection of facts that make Joovv such a serendipitous sponsor for this show because when Sarah thinks about the things that would bring someone to Botox her first reaction is - well, what about all the effective, safe things you can do instead Diet and hydration, exercise all have a huge impact on skin health If you are going to invest in something to improve your appearance cosmetically, Joovv red light therapy would be a route that is highly recommended There are a ton of studies showing that the two wavelengths in Joovv help to reduce inflammation and stimulate collagen production in the skin The two wavelengths used in Joovv actually make the skin physically younger, as opposed to just making it appear younger, which is what Botox does (53:34) Infrared Sauna vs. Joovv Therapy An infrared sauna is a higher wavelength that works by increasing your core temperature and forcing you to sweat, which is a detoxification pathway Joovv actually combines two different wavelengths, an infrared wavelength and a red wavelength It can still increase your core temperature if you sit in front of it for long enough, but the addition of the red light to the infrared light is what gives it the magical formula A red light goes deeper into your skin and is the main wavelength that is increasing cellular health Sarah finds Joovv to be the best of both worlds, and has actually found that their product is the only one actually delivering therapeutic doses If you want to shop Joovv, you can go to joovv.com/thepaleoview There are different sizes and different price points, and all offer the health benefits that Stacy and Sarah discussed (59:14) Final Thoughts There are also, of course, topical treatments that people can do to treat wrinkles, but a lot of the antiaging products that are on the market actually intentionally disrupt your hormones For those of us working really hard on lifestyle factors to regulate hormones, what you don't want to be doing is slathering yourself in some sort of cream that is just going to disrupt them Be careful about the products you are using Aging is not the most fun thing in the world There is not one magical thing that fixes everything, it is the little bit of benefit that we get from each choice (diet, lifestyle, the use of biohacks like Joovv) that compounds The goal for Sarah isn't to have her skin look younger, the goal is for her skin to be younger, and that is where the diet, lifestyle, and the smart use of biohacks that have scientific validity all comes together for magic (science) awesome Stacy wants to remind everyone that they are wonderful and beautiful just as you are Accepting yourself where you are and wanting to change is so important, so if there is something you want to change, Stacy suggests finding acceptance with yourself before you go on to find that next great thing because you might find that those laugh lines aren't something you actually want to change If this is something you have done already, this is not meant to be a dig on you Stacy and Sarah's goal is to simply help you be informed and make the best decisions for your health Thank you for tuning in and having patience on this deeply scientific show Thank you Sarah for pulling together all of this research and information Don't forget that you can submit follow up questions through both Stacy and Sarah's websites or on social media We will try to compile any questions received and if Stacy and Sarah need to do a follow-up show, we will as soon as we are able Stacy wished Sarah a wonderful trip to PaleoFx When Sarah returns, Stacy looks forward to discussing both of their wonderful trips

For episode 7 of the pharmaphorum podcast I spoke to Ipsen's Philippe Picaut about neurotoxin research, with a particular focus on Botulinum neurotoxins.

We delve into advanced management of headaches, including novel therapies, migraines with aura, migraines in complicated patients, and headaches of short duration with Dr. Rebecca Burch, a headache medicine specialist at the John R. Graham Headache Center at Brigham and Women’s Hospital. Full show notes available at http://thecurbsiders.com/podcast. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com. Credits Written and produced by: Paul Williams MD Edited by: Matthew Watto MD Hosts: Paul Williams MD, Stuart Brigham MD, Matthew Watto MD Guest: Rebecca Burch MD Time Stamps 00:00 Disclaimer, intro and guest bio 03:28 Guest one-liner, movie and podcast recommendations, favorite failure and picks of the week from The Curbsiders 10:38 Clinical case of migraines; diagnosis and classification 14:12 Does medication overuse headache exist? 16:16 Chronic daily headache; Conversion from episodic to chronic and vice versa 21:43 Approaches to medication overuse headache 25:54 Case 2: migraine with aura and other types of migraine (retinal, hemiplegic, etc.) 32:09 Pathophysiology of migraine; how triptans work; How should aura effect management? 38:44 Migraine cocktails 41:15 Comorbid mood disorders; Use of psych meds and triptans 45:08 Migraines and oral contraceptives 48:42 Botulinum toxin and new CGRP therapies 53:36 What does success look like in migraine therapy? 55:32 Nonpharmacologic management 60:45 Case 3: headaches of short duration 66:36 Headache red flags; Imaging for headaches; pathophysiology of high and low pressure headaches 72:00 Idiopathic intracranial hypertension 75:25 Take home points 77:00 Outro  

Did you know there's a brand new neurotoxin poised to come to market?  Did you know that Allergan snapped up the small biotech company for $195M as soon as their phase 2 clinical trial results were released?  Join us in this episode as we explore the personality and behavior of the latest botulinum toxin to join the Botox Party!   https://www.marketwatch.com/story/allergan-will-buy-neurotoxin-company-bonti-for-195-mln-2018-09-14 https://www.businesswire.com/news/home/20180802005452/en/Bonti-Announces-Successful-Completion-Phase-2a-Scar https://www.businesswire.com/news/home/20180509005700/en/Bonti-Announces-Start-LANTERN-2-Phase-2-Clinical

Botox treatments are a safe and effective way to remove wrinkles on ones face with quick results and little to no recovery time.

A lot of health buffs are saying that organic food is the way to go. Never mind the rest; stop buying the typical supermarket stock. Organic will save us all. But will it, really? Find out the truth about "organic" and misconceptions about this idea. You'll never look at "organic" food the same way again. Further reading: 1. Amanita phalloides (Death Cap) poisoning: https://www.ncbi.nlm.nih.gov/pubmed/26375431 2. Botulinum toxin: http://medind.nic.in/jaw/t09/i2/jawt09i2p10.pdf 3. Ricin: https://emergency.cdc.gov/agent/ricin/facts.asp --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/proper-science-podcast/message

Author: Michael Hunt, MD Educational Pearls: Here is a list of some very toxic natural substances:     #5: Tetrodotoxin: Found in pufferfish and other aquatic species #4: Ricin: made from castor beans #3: Mercury: natural element absorbable through skin and gloves #2: Batrachotoxin: found on poison dart frogs #1: Botulinum toxin: produced by Clostridium botulinum and causes a descending paralysis Editor's note: batrachotoxin is thought to be accumulated by the beatles and other insects dart frogs eat - those in captivity therefore are not poisonous References https://theconversation.com/handle-with-care-the-worlds-five-deadliest-poisons-56089

The emerging role of botulinum toxins as chemical neuromodulators, specifically in the management of chronic intractable painful syndromes, will be presented. There is compelling evidence showing that toxins modulate chronic neurogenic inflammation, commonly expressed as peripheral sensitization leading to central sensitization with allodynia and hyperalgesia. Existing medical literature will be discussed. Several cases successfully managed with type A botulinum toxins will be discussed, including chronic intractable headaches of several etiologies (migraine, posttraumatic, postintracranial bleed, etc), occipital neuralgia, intractable facial pain, temporomandibular joint pain syndromes, postradiation fibrosis, and other focal painful syndromes (ie, distal limb ischemic pain seen in Raynaud's phenomenon, temporal arteritis, and (others).

Yes, we have harnessed the power of paralysis. Botulinum toxin, which is produced by a lethal bacterium, Clostridium botulinum, has been bottled and sold to neurologists for decades. And you know this because you've seen people who received Botox to relax their facial muscles. In this week's installment, Dr. Anh-Thu Vu discusses how neurologists utilize this neurotoxic agent. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. The content in this episode was vetted and approved by Anh-Thu Vu. REFERENCES 1. Arnon SS, Schechter R, Inglesby T V, et al. Botulinum toxin as a biological weapon: medical and public health management. JAMA. 2001;285(8):1059-1070. 2. Thenganatt MA, Fahn S. Botulinum toxin for the treatment of movement disorders. Curr Neurol Neurosci Rep. 2012;12(4):399-409. doi:10.1007/s11910-012-0286-3. 3. Aurora SK, Winner P, Freeman MC, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373. doi:10.1111/j.1526-4610.2011.01990.x. 4. Dauer WT, Burke RE, Greene P, Fahn S. Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia. Brain. 1998;121 (Pt 4):547-560. 5. Karp BI. Botulinum toxin treatment of occupational and focal hand dystonia. Mov Disord. 2004;19 Suppl 8:S116-S119. doi:10.1002/mds.20025. 6. Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. Mov Disord. 2009;24(6):801-812. doi:10.1002/mds.22452. 7. Naumann M, Dressler D, Hallett M, et al. Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon. 2013;67:141-152. doi:10.1016/j.toxicon.2012.10.020. 8. Lotia M, Jankovic J. Botulinum Toxin for the Treatment of Tremor and Tics. Semin Neurol. 2016;36(1):54-63. doi:10.1055/s-0035-1571217.

SynTalk thinks about the tantalizing cocktail of poisons, toxins & venoms, and wonders if ‘what does not kill us makes us stronger’. We also constantly explore the striking similarity (in many ways) between medicine and poison (a la the vagueness of the word pharmakon). The concepts are derived off / from Sant Eknath, Parikshit, Derrida, & RG Macfarlane, among others. We peek into the world of snakes, scorpions, bacteria, rats, SNARE proteins, Botox, & bioterror. Why are there poisons in nature at all, and is there a link to the natural tendency towards ecological diversity? Is nothing poison in the world? How ‘the dose is the poison’. We (illustratively) explore the origins, structure, molecular & cellular actions, transmission, and dynamics of the Botulinum Neurotoxin (BoNT). How the Botulinum bacteria can survive for many months inside us (unlike any other bacteria). Do we have to have crime to have a stable society, and do poisonous plants & animals serve a parallel purpose in nature? How scorpion poison can be used to (potentially) treat Brugada Syndrome, and its links with cardiac sodium channel. How it is very difficult to use vaccines to permanently protect against venoms given the speed with which toxins act. We also borrow concepts such as padarth and dravya from vaiseshika philosophy to understand the (beautiful) metaphysical link of poison with the concept of ‘space’. How ‘substance’ is something that has different quality and action. Is venom a highly prestigious molecule for the snake itself for finding prey? How, then, do the non venomous snakes make a living? Why a child is (often) not afraid of a cobra? Is it possible to look at (molecular) structure and predict its (poisonous) action? Is it possible to identify the exact molecule (& not the cocktail) responsible for blocking the pre synaptic receptors? Is a more advanced society more vulnerable to poisons? What does poison look like? Should our nature ‘be’ to understand poisons? The SynTalkrs are: Dr. H.S. Bawaskar (medicine, Bawaskar Hospital & Research Centre, Mahad), & Prof. Bal Ram Singh (biophysical chemistry, indic studies, UMass, Dartmouth).

Sat, 12 Jul 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/17313/ https://edoc.ub.uni-muenchen.de/17313/1/Bechter_Martina_R.pdf Bechter, Martina Ramona

A neurobiologist discusses the medical uses of Botulinum Toxin A

Sergio PANTANO Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, URUGUAY speaks on "Botulinum neurotoxins and SNARE mediated neuroexocytosis: from complex to super complex". This seminar has been recorded by ICGEB Trieste

Jon Lund talks about the presentation, aetiology and treatment of anal fissure, explaining the aetiology with the help of diagrams in this video podcast. Get in touch though School of Surgery at podomatic.com and request topics you'd like to have available as podcasts

Why can't we tickle ourselves? Is deafness down to our genes? Can diabetes cause Eczema? How does deodorant prevent body odour? We take on these questions in this week's show as well as reveal if botox can be used as a medicine, why some people don't feel pain and whether it's possible to wake up with a new accent. Plus we investigate if bacteria could be used to clean the oil spill in the gulf of Mexico! Like this podcast? Please help us by supporting the Naked Scientists

Why can't we tickle ourselves? Is deafness down to our genes? Can diabetes cause Eczema? How does deodorant prevent body odour? We take on these questions in this week's show as well as reveal if botox can be used as a medicine, why some people don't feel pain and whether it's possible to wake up with a new accent. Plus we investigate if bacteria could be used to clean the oil spill in the gulf of Mexico! Like this podcast? Please help us by supporting the Naked Scientists

The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O. Micromolar concentrations of free Ca2+ evoked amylase release from these cells. Maximal release was observed in the presence of 30 microM free Ca2+. Ca(2+)-stimulated, but not basal, amylase release was enhanced by guanosine 5'-[gamma-thio]triphosphate (GTP[S]) (3-4 fold) or cyclic AMP (1.5-2 fold). Neither the two-chain forms of botulinum A toxin and tetanus toxin, under reducing conditions, nor the light chains of tetanus toxin, inhibited amylase release triggered by Ca2+, or combinations of Ca2+ + GTP[S] or Ca2+ + cAMP. The lack of inhibition was not due to inactivation of botulinum A toxin or tetanus toxin by pancreatic acinar cell proteolytic enzymes, as toxins previously incubated with permeabilized pancreatic acinar cells inhibited Ca(2+)-stimulated [3H]noradrenaline release from streptolysin O-permeabilized adrenal chromaffin cells. These data imply that clostridial neurotoxins inhibit a Ca(2+)-dependent mechanism which promotes exocytosis in neural and endocrine cells, but not in exocrine cells.

The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay. In the presence of the reducing agent dithiothreitol, the two-chain form of botulinum A toxin inhibited vasopressin release induced by 10 μM free calcium. Half maximal inhibition was obtained with 15 nM botulinum A toxin. In the absence of the heavy chain the light chain of the toxin strongly inhibited exocytosis with a half maximal effect of 2.5 nM. The inhibitory effects on secretion could be prevented by incubating the light chain with an immune serum against botulinum A toxin. The heavy chain of botulinum A toxin did not affect vasopressin release. However, it prevented the inhibitory effects of the light chain on stimulated exocytosis. It is concluded that botulinum A toxin inhibits the calcium-dependent step leading to exocytosis by interfering with a target present in the isolated and permeabilized nerve terminals. The functional domain of this neurotoxin, which is responsible for the inhibition of vasopressin release, is present in its light chain.

The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O. Purified light chain inhibited the Ca2+-stimulated [3H]noradrenaline release with a half-maximal effect at about 1.8 nM. The inhibition was incomplete. Heavy chain up to 28 nM was neither effective by itself nor did it enhance the inhibitory effect of light chain. It is concluded that the light chain of botulinum A toxin contains the functional domain responsible for the inhibition of exocytosis.

Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern., in press]. The related botulinum A toxin also consists of a heavy and a light chain linked by a disulfide bond. The actions ofboth neurotoxins on exocytosis were presently compared using streptolysin O-permeabilized bovine adrenal chromaffin cells. Botulinum A toxin inhibited Ca2 +-stimulated catecholamine release from these cells. Addition of dithiothreitollowered the effective doses to values below 5 nM. Under the same conditions, the effective doses of tetanus toxin were decreased by a factor of five. This indicates that the interchain S-S bond of botulinum A toxin must also be split before the neurotoxin can exert its effect on exocytosis.