Podcasts about Botulinum toxin

We call them "Botox" but there's really 6 different botulinum toxins now - Botox was the first one and so its name is like "Kleenex" for tissues.  But Xeomin, Dysport, Jeuveau, Daxxify, and now Letybo are all competing for a piece of the lucrative market.  It turns out that the industry leader Botox might not be the best "Botox" after all.  Tune in to find out which product wins the prize for the fastest onset and the longest duration botulinum toxin.  

Moderator: Nihat Mustafayev (Istanbul, Türkiye)Guest: Dr Anna Castagna (Milano, Italy) This episode explains how ultrasound-guided botulinum toxin injections are performed in patients with dystonia. Mustafayev and Castagna discuss who benefits most from this method and why it is considered a safe and effective approach in clinical practice.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely already an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password'-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department (membership@ean.org) to cross-check if you are listed as an Associate Member to get access to eanCampus.

Dr Robert Trujanovic is an EBVS European Specialist in Veterinary Anaesthesia & Analgesia. In our latest podcast we talk to Robert to share his experience of using botulinum toxin A in pain management in dogs. Robert is leading the field on this subject and brings his experience of interventional pain management to our Zero Pain community. We exploreWhat is the mechanism of action of BT?What sort of pain cases is BT used for in human medicine?Can you please tell us about some cases where you have successfully used BT in dogs (any feline experience)Are there some practical considerations you would like to mention?References·      Pioneering pain management with botulinum toxin type A: From anti-inflammation to regenerative therapies. Hamta Rahmatipour, Salar Mohammadi Shabestari, Soheila Zamanlui Benisi, Hamidreza Samadikhah ·      Botulinum toxin for the treatment of chronic pain. Review of the evidence. Roberto Carlo Rivera Día, Mario Andrés Arcila Lotero, María Victoria Avellaneda Suarez, Sara Echeverri Saldarriaga, Manuela Gómez Martínez ·      Botulinum Toxin in Chronic Lateral Epicondylitis, from Tendon to Muscle Approach—A Review ·      Transforaminal versus Intra-Articular Facet Corticosteroid Injections for the Treatment of Cervical Radiculopathy: A Randomized, Double-Blind, Controlled Study N.J. Bureau, T. Moser, J.H. Dagher, D. Shedid, M. Li, P. Brassard and B.E. Leduc ·      Retrodural space of Okada in the posterior ligamentous complex region: clinical and anatomical findings relevant to lumbar interlaminar epidural injection

Gretch Elizabeth is a patient advocate, education development admin, and Awareness Lead at ToxSafety.com, an umbrella coalition dedicated to promoting patient safety and informed decision making regarding botulinum toxin injections, more commonly known as BOTOX. In this conversation with Gretch we discussed:The personal experience that pulled her into this worldA close look at botulinum toxin and how it entered the world of cosmetic treatmentThe myriad side effects of botulinum toxin injections, including deathHow side effects are a "when" not "if" scenarioThe added danger of repeat treatments...and more!Learn more about Gretch and her work at https://www.toxsafety.com/.Follow her and her work on social at:https://www.instagram.com/nevertoxhttps://www.facebook.com/nevertoxhttps://www.facebook.com/groups/224009391310103  https://www.youtube.com/@nevertoxhttps://www.threads.net/@nevertoxSupport Terrain Theory on Patreon! Our recently-launched member platform gives you access to a ton of free & exclusive content. Check it out: https://www.patreon.com/TerrainTheoryTerrain Theory episodes are not to be taken as medical advice. You are your own primary healthcare provider.If you have a Terrain Transformation story you would like to share, email us at ben@terraintheory.net.Learn more at www.terraintheory.netMusic by Chris Merenda

Is looking wrinkle-free really worth injecting a neurotoxin that could mess with your brain, body, and hormones? In this eye-opening episode, I'm joined by truth-teller and health advocate Gretch Elizabeth from NeverTox to pull back the curtain on one of the most accepted—and least questioned—cosmetic procedures: Botox. What if the pursuit of smooth skin is quietly sabotaging your health? Gretch breaks down the science behind botulinum toxin—the neurotoxin that, with repeated injections, may have long-term, life-threatening consequences. This is the conversation every woman deserves before saying “yes” to the needle. Gretch Elizabeth is a passionate patient advocate who helps run the Never Tox Community Group—the largest international Botox injury support group in the world—dedicated to supporting individuals affected by botulinum toxin injuries through resources and education. Gretch and her team have worked tirelessly to promote informed consent. We're talking facts, risks, and informed alternatives—because you should never have to choose between beauty and health. **Follow, subscribe, and leave a review if this episode challenged what you've been told and opened your eyes to better options. ✴️ Connect with Gretch on Facebook, Instagram, Threads, or YouTube

เปิดพอดแคสต์เอพิโสดนี้ใน YouTube เพื่อประสบการณ์การรับชมที่ดีที่สุด ในวงการความงามโบทูลินัมท็อกซิน (Botulinum Toxin) คือหนึ่งในผลิตภัณฑ์ที่ได้รับความนิยมสูงสุดทั้งในระดับโลกและประเทศไทย ท่ามกลางการแข่งขันที่ดุเดือดและผู้เล่นรายใหม่ที่เข้าสู่ตลาดอย่างต่อเนื่อง แต่หนึ่งในผู้เล่นที่โดดเด่นที่สุดคงหนีไม่พ้นโบทูลินัมท็อกซินสัญชาติเกาหลีใต้ ซึ่งขึ้นชื่อเรื่องการสร้างสรรค์นวัตกรรมที่พลิกโฉมวงการความงามอย่างต่อเนื่อง The Secret Sauce เอพิโสดนี้ พูดคุยกับ Hyunho Jung, Ph.D. หรือ ดร.จอง นักวิทยาศาสตร์ และประธานเจ้าหน้าที่บริหาร บริษัท Medytox ซึ่งเป็นบริษัท Biopharmaceutical ชั้นนำของเกาหลีใต้ ผู้ค้นพบโบทูลินัมท็อกซินสายพันธุ์ใหม่ และพัฒนาผลิตภัณฑ์ ในรูปแบบสารละลายครั้งแรกของโลก เขาจะมาเล่าถึงเส้นทางจากการวิจัยสู่การสร้างธุรกิจระดับโลก และความร่วมมือกับบริษัทไทยที่ทำให้ Medyceles ก้าวขึ้นเป็นผู้นำตลาดความงามในประเทศไทย ติดตามชมได้ในเอพิโสดนี้

Pediatric ophthalmologists Drs. Michelle Cabrera and Alejandra de Alba join host Dr. Ben Young to discuss the pros and cons of using botulinum toxin (Botox) for treating patients with strabismus, and whether every pediatric ophthalmologist—or even general ophthalmologist—should have this technique in their toolbox. For all episodes or to claim CME credit for selected episodes, visit www.aao.org/podcasts.

Tangential Biopsy of the Nil Bed and Matrix, with Plate Evaluation, for Diagnosis of Lichen Planus. Bertanha L, Michalany AO, Damas II, Di Chiacchio N, Cintra ML. JEADV. 2024. online ahead of print.Botulinum Toxin Injection shows promise in Nail Psoriasis: A comparative randomized controlled trial. Juntongjin P, Srisinlapakig S, Nitayavardhana S. JAAD Int. 2024 Apr 30;16:105-111.

Un nouvel épisode du Pharmascope est disponible! Dans ce 145e épisode, Nicolas, Isabelle et Olivier essaient de ne pas trop vous faire trembler en revisitant une vieille littérature et un problème incommodant : le tremblement essentiel. Les objectifs pour cet épisode sont les suivants: Expliquer l'épidémiologie, la présentation clinique et l'évaluation du tremblement essentiel. Conseiller des mesures non-pharmacologiques pour aider les personnes avec un tremblement essentiel. Discuter des bénéfices et des désavantages associés aux principaux traitements pharmacologiques du tremblement essentiel. Ressources pertinentes en lien avec l'épisode  Shanker V. Essential tremor: diagnosis and management. BMJ. 2019 Aug 5;366:14485 Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK. Essential tremor. Nat Rev Dis Primers. 2021 Nov 11;7(1):83. Baizabal-Carvallo JF, Morgan JC. Drug-induced tremor, clinical features, diagnostic approach and management. J Neurol Sci. 2022 Apr 15;435:120192 Ferreira JJ et coll. MDS Task Force on Tremor and the MDS Evidence Based Medicine Committee. MDS evidence-based review of treatments for essential tremor. Mov Disord. 2019 Jul;34(7):950-958. Serrano-Dueñas M. Use of primidone in low doses (250 mg/day) versus high doses (750 mg/day) in the management of essential tremor. Double-blind comparative study with one-year follow-up. Parkinsonism Relat Disord. 2003 Oct;10(1):29-33. Bruno E, Nicoletti A, Quattrocchi G, Allegra R, Filippini G, Colosimo C, Zappia M. Topiramate for essential tremor. Cochrane Database Syst Rev. 2017 Apr 14;4(4):CD009683. Ondo WG, Jankovic J, Connor GS, Pahwa R, Elble R, Stacy MA, Koller WC, Schwarzman L, Wu SC, Hulihan JF; Topiramate Essential Tremor Study Investigators. Topiramate in essential tremor: a double-blind, placebo-controlled trial. Neurology. 2006 Mar 14;66(5):672-7. Bruno E, Nicoletti A, Quattrocchi G, Filippini G, Colosimo C, Zappia M. Pregabalin for essential tremor. Cochrane Database Syst Rev. 2016 Oct 20;10(10):CD009682 Bruno E, Nicoletti A, Quattrocchi G, Filippini G, Zappia M, Colosimo C. Alprazolam for essential tremor. Cochrane Database Syst Rev. 2015 Dec 6;2015(12):CD009681. Marques A et coll. Trial of Botulinum Toxin for Isolated or Essential Head Tremor. N Engl J Med. 2023 Nov 9;389(19):1753-1765. Yetimalar Y, Irtman G, Kurt T, Başoğlu M. Olanzapine versus propranolol in essential tremor. Clin Neurol Neurosurg. 2005 Dec;108(1):32-5.

Here I talk about the history of botulinum toxin, the different brands such as Botox, Bocoture, Azzalure and the newest brand Alluzience. I give my honest opinion on these brands. I talk to about the illegal brands on the market and much more. One of the most educational podcasts that you will find on botulinum toxin. This is not to be missed.

Why did Queen Elizabeth I look like she was auditioning for a role in a ghost story? In this episode of Join the Docs, our dynamic duo, Professor Jonathan Sackier and Dr. Nigel Guest, take a spook-tacular yet enlightening plunge into the world of historical beauty practices. They shine a spotlight on the iconic Queen Elizabeth I, whose beauty regimen had her looking  as white as a sheet twith an approach  as dangerous as a game of dodgeball with porcupines. The societal preference for pale skin back then was no joke, but the makeup they used certainly was—Venetian ceruse, a concoction so toxic it would make a chemistry teacher cry. This lead-laden face paint was the Elizabethan equivalent of playing Russian roulette with your health.Ever wondered what happens when you mix pore judgement with a dash of danger?  Well, Professor Sackier and Doctor Guest are here to spill the creams—or rather, the ceruse. They dive into the health risks associated with these historical beauty practices, painting a vivid picture of lead poisoning that's more terrifying than a haunted house. While the ghostly pallor was deemed attractive to our ancestors, we wonder if the lead-induced  cognitive impairment was valued, making it clear that looking like a porcelain doll came at a steep price. And let's not forget the long-term effects, like infertility, which was nature's way of saying, "Maybe don't put poison on your face."How did people back then not realise they were essentially turning themselves into walking, talking toxic waste dumps? The Docs, with their signature blend of humour and expertise, unravel this mystery while keeping you in stitches (metaphorically). They highlight the absurdity of historical beauty standards, making you grateful for modern skincare routines that don't involve hazardous materials.By the end of the episode, you'll be convinced that no amount of societal pressure is worth risking your health. So, next time you reach for that new beauty product, remember the powderful lessons of yesteryear and choose health over hazardous habits—or you might just makeup your mind the hard way!—--DISCLAIMER: The views and opinions expressed on Join the Docs are those of Dr. Nigel Guest, Jonathan Sackier and other people on our show. Be aware that Join the Docs is not intended to be medical advice, it is for information and entertainment purposes only - please, always take any health concerns to your doctor or other healthcare provider. We respect the privacy of patients and never identify individuals unless they have consented. We may change details, dates, place names and so on to protect privacy. Listening to Join the Docs, interacting on our social media, emailing or writing to us does not establish a doctor patient relationship.To Contact Us: For a deeper dive on this episode's issue, merchandise and exclusive content, head to www.jointhedocs.comFollow us on youtube.com/JoinTheDocs Follow us on instgram.com/JoinTheDocsFollow us on tiktok.com/JoinTheDocsFollow us on: facebok.com/JoinTheDocsFollow us on: x.com/JoinTheDocs

Have you ever wondered how a deadly toxin found in spoiled sausages could end up being the secret behind wrinkle-free foreheads? In this rib-tickling episode of Join the Docs, our dynamic duo, Professor Jonathan Sackier and Doctor Nigel Guest, take you on a wild ride through the history and medical marvels of botulinum toxin, affectionately known as Botox. The Docs kick things off by tracing its origins back to the days of the Roman Empire, where improperly prepared sausages were more than just a culinary faux pas—they were a lethal hazard! With a sprinkle of humour, the hosts reveal their own sausage preferences, from bratwurst to bangers, and even throw in a few sausage puns that are sure to make you "wurst" with laughter.Did you know that Botox isn't just for keeping those pesky crow's feet at bay? In a clinical  but not cynical twist, Sackier and Guest dive into the surprising medical applications of Botox that go way beyond the realm of vanity. They discuss how this toxin, once feared for its deadly potential, is now a miracle worker in treating muscle spasms and conditions from mouth to anus. Imagine a toxin that can both paralyse and heal—talk about a toxin-ating paradox behind Botox is not only understandable but downright entertaining.Ever thought about the culinary disasters that led to medical breakthroughs? The Docs certainly have, and they share some laugh-out-loud anecdotes about historical food poisoning incidents that paved the way for modern medicine. From ancient Roman feasts gone awry to mediaeval sausage mishaps, The Docs paint a vivid picture of how botulinum toxin transitioned from a kitchen nightmare to a medical marvel. Their light-hearted approach ensures that even the most complex medical topics are as easy to digest as a well-cooked sausage—minus the botulinum, of course!So, why not join Professor Sackier and Doctor Guest for an episode that's as enlightening as it is entertaining? With their perfect blend of humour and expertise, they make the history and uses of Botox a topic you won't soon forget. Whether you're a medical professional or just someone curious about the quirks of history, this episode of Join the Docs promises to be a wrinkle in time you won't want to miss!—--DISCLAIMER: The views and opinions expressed on Join the Docs are those of Dr. Nigel Guest, Jonathan Sackier and other people on our show. Be aware that Join the Docs is not intended to be medical advice, it is for information and entertainment purposes only - please, always take any health concerns to your doctor or other healthcare provider. We respect the privacy of patients and never identify individuals unless they have consented. We may change details, dates, place names and so on to protect privacy. Listening to Join the Docs, interacting on our social media, emailing or writing to us does not establish a doctor patient relationship.To Contact Us: For a deeper dive on this episode's issue, merchandise and exclusive content, head to www.jointhedocs.comFollow us on youtube.com/JoinTheDocs Follow us on instgram.com/JoinTheDocsFollow us on tiktok.com/JoinTheDocsFollow us on: facebok.com/JoinTheDocsFollow us on: x.com/JoinTheDocs

ชมวิดีโอ EP นี้ใน YouTube เพื่อประสบการณ์การรับชมที่ดีที่สุด ปัจจุบันอุตสาหกรรมความงามด้านการแพทย์เติบโตขึ้นเรื่อยๆ เนื่องจากคนรุ่นใหม่ให้ความสนใจกับสุขภาพและร่างกาย ประกอบกับนวัตกรรมความงามที่พัฒนาอย่างก้าวหน้า กลายเป็นโอกาสในตลาดความงาม หนึ่งในนั้นคือ Apex Hospital & Beauty clinic ผู้บุกเบิกความงามที่นำเข้าเทคโนโลยีสู่เมืองไทยเมื่อหลายสิบปีก่อน เช่น Botulinum toxin, สารเติมเต็ม, เครื่องสลายไขมันด้วยความเย็น ซึ่งก่อตั้งโดยหมอผิวหนังที่เรียนจบจากอเมริกา ได้เห็นความต้องการของผู้บริโภค ประกอบกับเป็นผู้ติดตามความเคลื่อนไหวเทรนด์เทคโนโลยีความงาม จึงเป็นจุดเริ่มต้นสร้างธุรกิจความงามที่สร้างรายได้มหาศาลและมีชื่อเสียงโด่งดังในปัจจุบันนี้ เบื้องหลังความสำเร็จคืออะไร เคน นครินทร์ พูดคุยกับ พญ.นันทภัทร์ สุภาพรรณชาติ ผู้ก่อตั้ง Apex Hospital & Beauty Clinic ถึงวิสัยทัศน์และกลยุทธ์พลิกเกมธุรกิจด้วยนวัตกรรม ติดตามชมได้ใน The Secret Sauce เอพิโสดนี้ ฆสพ.สบส.110/2561 

ปัจจุบันอุตสาหกรรมความงามด้านการแพทย์เติบโตขึ้นเรื่อยๆ เนื่องจากคนรุ่นใหม่ให้ความสนใจกับสุขภาพและร่างกาย ประกอบกับนวัตกรรมความงามที่พัฒนาอย่างก้าวหน้า กลายเป็นโอกาสในตลาดความงาม หนึ่งในนั้นคือ Apex Hospital & Beauty clinic ผู้บุกเบิกความงามที่นำเข้าเทคโนโลยีสู่เมืองไทยเมื่อหลายสิบปีก่อน เช่น Botulinum toxin, สารเติมเต็ม, เครื่องสลายไขมันด้วยความเย็น ซึ่งก่อตั้งโดยหมอผิวหนังที่เรียนจบจากอเมริกา ได้เห็นความต้องการของผู้บริโภค ประกอบกับเป็นผู้ติดตามความเคลื่อนไหวเทรนด์เทคโนโลยีความงาม จึงเป็นจุดเริ่มต้นสร้างธุรกิจความงามที่สร้างรายได้มหาศาลและมีชื่อเสียงโด่งดังในปัจจุบันนี้ เบื้องหลังความสำเร็จคืออะไร เคน นครินทร์ พูดคุยกับ พญ.นันทภัทร์ สุภาพรรณชาติ ผู้ก่อตั้ง Apex Hospital & Beauty Clinic ถึงวิสัยทัศน์และกลยุทธ์พลิกเกมธุรกิจด้วยนวัตกรรม ติดตามชมได้ใน The Secret Sauce เอพิโสดนี้ ฆสพ.สบส.110/2561

Dr. Marisa Heyns, from Dr. Nerina Wilkinson & Associates, is a General Practitioner, who specialises in Aesthetic Medicine. She obtained her medical degree at the University of Cape Town and is one of only a few doctors in South Africa with a European master's degree in Aesthetic Medicine and Therapeutics (UNICAM, Italy). She brings a wealth of knowledge about regenerative skin treatments.  We chat about the 3D MD PRP (Platelet Rich Plasma) Facial aka The Vampire Facial, Rosacea, Botulinum Toxin, the stigma around cosmetic surgery and the impact Social Media has!

Neste episódio em formato de Journal Club, convidamos a Dra Dayane Issaho, atual presidente do CBE e host desse podcast, para falar sobre o artigo The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis, publicado na IOVS. Dra Dayane traz dados para elucidarmos uma questão que sempre traz dúvidas e insegurança entre estrabólogos: quando optar e quais as chances de sucesso quando usamos toxina botulínica para tratar estropias na infância. Não deixe de ouvir e compartilhar!!O acesso ao artigo completo está disponível no link: https://iovs.arvojournals.org/article.aspx?articleid=2659615

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 Yes, we have harnessed the power of paralysis. Botulinum toxin, which is produced by a lethal bacterium, Clostridium botulinum, has been bottled and sold to neurologists for decades. And you know this because you've seen people who received Botox to relax their facial muscles. In this week's installment, Dr. Anh-Thu Vu discusses how neurologists utilize this neurotoxic agent. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision-making in routine clinical practice. The content in this episode was vetted and approved by Anh-Thu Vu. REFERENCES Arnon SS, Schechter R, Inglesby TV, et al. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2001;285(8):1059-70. Erratum in: JAMA 2001;285(16):2081. PMID 11209178Aurora SK, Winner P, Freeman MC, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache 2011;51(9):1358-73. PMID 21883197Dauer WT, Burke RE, Greene P, Fahn S. Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia. Brain. 1998 Apr;121 ( Pt 4):547-60. PMID 9577384Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. Mov Disord 2009;24(6):801-12. PMID 19224614Karp BI. Botulinum toxin treatment of occupational and focal hand dystonia. Mov Disord 2004;19 Suppl 8:S116-9. PMID 15027063Lotia M, Jankovic J. Botulinum toxin for the treatment of tremor and tics. Semin Neurol 2016;36(1):54-63. PMID 26866497Naumann M, Dressler D, Hallett M, et al. Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon 2013;67:141-52. PMID 23178324Thenganatt MA, Fahn S. Botulinum toxin for the treatment of movement disorders. Curr Neurol Neurosci Rep 2012;12(4):399-409. PMID 22661378  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

In this insightful episode of "The History of Eyecare," host Dr. Morgan Micheletti sits down with Dr. Ted Wojno, an eminent figure in ophthalmology and oculoplastic surgery. Dr. Wojno, renowned for his pioneering work, sheds light on the evolution and impact of Botox in eye care. He navigates through its journey from a substance of intrigue to a mainstay in both therapeutic and cosmetic treatments, elaborating on its transformative role in managing various ocular conditions. The conversation then pivots to the realm of oculoplastic surgery, where Dr. Wojno's expertise truly shines. He discusses the advancements in surgical techniques and materials, particularly emphasizing the use of porous polyethylene, or Porex, in reconstructive procedures. Dr. Wojno illustrates how this material has revolutionized patient outcomes, offering improved integration with tissue and greater flexibility in surgeries. Throughout the episode, listeners gain a deeper understanding of these innovative practices that have significantly influenced modern eye care. Dr. Wojno's experiences and insights offer a unique glimpse into the dynamic field of ophthalmology, making this episode a must-listen for professionals and enthusiasts alike.

Chronic headaches are extremely debilitating conditions which significantly impact the quality of life. Dr Giorgio Pietramaggiori and Dr Saja Scherer of Global Medical Institute, Switzerland employ minimally invasive treatments such as targeted Botox injections, surgical release of nerves, and fat transfer, which aim to offer relief for people suffering from chronic headaches when pharmacological alternatives fail. Read more in Research Features: doi.org/10.26904/RF-149-5161384107Read the original research: doi.org/10.1097/prs.0000000000009777

Face, poison, needles. It just makes sense. Plus, nothing else has worked on this season of Silver Bullet. But are your brave hosts about to give up? Or are they about to pay a registered nurse to palm slam a few CCs of botulinum toxin into their facial muscles? The second one. It's the second one.

Jenny sits down for the second time with her personal skin care nurse and skilled beauty specialist Christine Bui, who joins us this week to share her insight, knowledge and stories about common age-defying treatments such as dermal fillers, neurotoxin injections and more. We find out how to identify the best injectors, what treatments target which areas of desired enhancement, and how to get the best results for your needs. Mention this episode and get $100 OFF your next treatment with Nurse Christine!Enduring Beauty WebsiteFollow Nurse Christine on IG: @nursechristinern If you enjoyed this episode, make sure and give us a five star rating  and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox.  Get The MOST Incredible Offer HERE - Join the NEW STRONG Fitness Membership today!Get Your Perfect Sports 20% Discount here by using coupon code: JVBSave $100 off Your MAXPRO Fitness hereApply for the STRONG Formula Certification Program WORK WITH A TEAM STRONG GIRLS COACHSTRONG Fitness Magazine Subscription Use discount code PODCAST  Resources:STRONG Fitness MagazineSTRONG Fitness Magazine on IGTeam Strong GirlsCoach JVB Follow Jenny on social media:InstagramFacebookYouTube https://Jennifer Van Barneveld - Pe

There has been a significant increase in the number of non-surgical aesthetic procedures over the past decade. And now the largest academic survey to date in the UK has just been published, relating the lived experience of over 500 people who have experienced an adverse event following administration of Botulinum Toxin. The study finds that a lack of awareness of reporting structures and the lack of regulation within the UK's cosmetic injectables sector represents a significant public health challenge. Nuala is joined by the senior author of the study Ash Mosahebi, Professor of Plastic Surgery, and by Genee Schock who took part in the survey and runs a side effects support group for people impacted. How much time would it take to photograph every single item in your home? Photographer Barbara Iweins spent four years documenting the 12,795 objects she owns. Barbara wanted 'to see the representation – flat on the ground – of a mother and her children.' She joins Nuala. Victoire Ingabire Umuhoza is the leader of the opposition in Rwanda. She talks to Nuala about the challenges facing women and girls in Rwanda as well as the proposed UK-Rwanda asylum plan. Tributes are being paid to the former Labour MP Ann Clwyd, who has died at the age of 86. Not only Wales' longest-serving woman MP, Ann also became known as a passionate human rights campaigner, committing herself to many causes, including the banning of FGM - female genital mutilation - in the UK. In 2003 she introduced the Female Genital Mutilation Act, making it illegal to take a girl out of the UK to undergo FGM in another country. Nuala is joined by Hibo Wardere, anti-FGM activist and author of Cut.

On Saturday, July 15, Dr. Marianne T. Ritchie spoke with Steven Markos, MD about BOTOX, the familiar trade name for a treatment that uses small amounts of the chemical that causes botulism to weaken/paralyze muscles for therapeutic reasons. 

Your Real Champion®: TODAY is a Good Day

Plasma cells and derm with Dr. Alicia Schnebelen - Subcutaneous fat necrosis of the newborn - Lenabasum: A cannabinoid for dermatomyositis - Botulinum toxin for Hailey-Hailey and Darier's disease - Dr. Schnebelen's lab: https://pathnetlab.com/ Alicia Schnebelen on social media: https://www.instagram.com/skinandscope/?hl=en https://twitter.com/skinandscope?lang=en Check out our video content on VuMedi!: https://www.vumedi.com/channel/dermasphere/ Luke's PDPC course and the Intermountain Derm Society meeting: ⁠⁠⁠https://registration.socio.events/e/idspdpc23/promo-codes/ATTENDEE⁠⁠ The University of Utah's Dermatology ECHO: ⁠⁠https://physicians.utah.edu/echo/dermatology-primarycare⁠⁠Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

Live interview with Dr Loren Fishman For more resources and information on the study check https://sciatica.org/research/ Contact Dr Loren Fishman on (212) 472-0077 Email: scoliosis@sciatica.org -------------------------------------------------------------------- MOVE WITH SCOLIOSIS RESOURCES1) Download the FREE printable yoga for scoliosis sample practice plan https://movewithscoliosis.com/free-printable-sequence/ 2) Join our Yoga for Scoliosis Facebook group https://www.facebook.com/groups/yogaforscoliosis/  for more support and inspiration. 3) Join […]

Dr. Ronald Moy provides an update in botulinum toxins, including dosing and dilution and how to differentiate your practice by minimizing pain and bruising.

Gretch Elizabeth is a natural researcher, former high school teacher, beauty industry educator, and the founder of Never Tox. Never Tox is an online community of over 25,000 people that offers education about Botox and supports those experiencing side effects. While Botox – also known as Botulinum Toxin – is a known neurotoxin (and “one…

Did you know people living with Parkinson's can receive botulinum toxin (aka Botox) injections to help relieve rigidity and in some cases tremors and even drooling? Learn more from Dr. Patel, MDS at OhioHealth.

Studies in Androgenetic Alopecia and Alopecia Areata   STUDIES REFERENCED   MINOXIDIL CONCENTRATIONS   Singh et al (starts at 10:10). Does topical minoxidil at concentrations higher than 5% provide additional clinical benefit? Clin Exp Dermatol. 2022 Nov;47(11):1951-1955   Olsen EA, Dunlap FE, Funicella T et al (starts at 13:22). A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 2002; 47: 377–85   McCoy J, Goren A, Kovacevic M, Shapiro J (starts at 16:02). Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil. J Biol Regul Homeost Agents 2016;30: 1153–5   Goldust M (starts at 17:25). Minoxidil 15% solution versus minoxidil 5%solution in the treatment of androgenetic alopecia. Br JDermatol 2020;183(Suppl): 91 (abstract BH107)   Ghonemy S, Alarawi A, Bessar H (starts at 18:11). Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgeneticalopecia: a trichoscopic evaluation. J Dermatolog Treat 2021;32: 236–41     JAK INHBITORS FOR ANDROGENETIC ALOPECIA   Casale F et al (starts at 22:19). Are Janus kinase (JAK) inhibitors beneficial in the treatment of androgenic alopecia? Int J Dermatol. 2022 Nov;61(11):e457-e458.   BOTOX FOR ANDROGENETIC ALOPECIA   English RS Jr and Ruiz S (starts at 29:30). Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review. Skin Appendage Disord. 2022 Mar;8(2):93-100   Shon U, Kim MH, Lee DY, Kim SH, Park BC (starts at 33:48). The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism. J Am Acad Dermatol. 2020 Dec;83(6):1838–9.     PLATELET RICH PLASMA TREATMENTS FOR ANDROGENETIC ALOPECIA Gupta AK and Bamimore M (starts at 39:09). Platelet-Rich Plasma Monotherapies for Androgenetic Alopecia: A Network Meta-Analysis and Meta-Regression Study. J Drugs Dermatol. 2022 Sep 1;21(9):943-952.   de Oliveira AFQ et al (starts at 42:25). Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis. J Dermatolog Treat. 2022 Oct 31:1-11.   LOW DOSE ORAL MINOXIDIL SIDE EFFECTS   Dlova et al (starts 45:41). Pericardial, pleural effusion and anasarca: A rare complication of low-dose oral minoxidil for hair loss. JAAD Case Rep. 2022 Aug 11;28:94-96.   Randolph M, Tosti A (starts at 53:22). Oral minoxidil treatment for hair loss: a review of efficacy and safety. J Am Acad Dermatol. 2021;84(3): 737-746.     LOW DOSE ORAL MINOXIDIL EFFICACY AND SAFETY     Gupta AK et al (starts at 57:33). There Is a Positive Dose-Dependent Association between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings from a Systematic Review with Meta-Regression Analyses. Skin Appendage Disord. 2022 Sep; 8(5): 355–36     JAK INHIBITORS AND VENOUS THROMBOEMBOLISM Chen T-L et al (starts at 1:02:14). Association of Risk of Incident Venous Thromboembolism With Atopic Dermatitis and Treatment With Janus Kinase Inhibitors: A Systematic Review and Meta-analysis. JAMA Dermatol. 2022 Aug 24;e223516.   King B et al (1:05:33). Two Phase 3 Trials of Baricitinib for Alopecia Areata. N Engl J Med. 2022 Mar 26.   Misra D et al (starts at 1:11:19). Cardiovascular risks associated with Janus kinase inhibitors: peering outside the black box. Clin Rheumatol. 2022 Oct 20.     RISING PREVALENCE OF ALOPECIA AREATA IN JAPAN   Campos-Alberto E et al (starts at 1:13:00). Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descriptive study using Japan medical data center claims database. J Dermatol. 2022 Nov 2.   COVID VACCINATION AND ALOPECIA AREATA RISK   Tassone F et al (starts at 1:15:21). Alopecia Areata Occurring after COVID-19 Vaccination: A Single-Center, Cross-Sectional Study. Vaccines (Basel). 2022 Sep 5;10(9):1467.   Nguyen B and Tosti A (starts at 1:21:22). Alopecia areata after COVID-19. J Eur Acad Dermatol Venereol. 2022 Aug 11;10.1111/jdv.18491.   Babadjouni  A et al (starts at 1:30:21). COVID-19 vaccination related exacerbations of hair loss in patients with moderate-to-severe alopecia areata on systemic therapy. JAAD Case Rep . 2022 Nov;29:181-185.   Chen C-H et al (starts at 1:36:55). Intractable alopecia areata following the second dose of COVID-19 vaccination: Report of two cases. Dermatol Ther. 2022 Sep;35(9):e15689.  

Lots of guys wish they could add a few more inches to their manhood. Until recently, there wasn't a way for men to increase the girth of their "package". But... now there is a way! That's why I invited Dr. John Leonardo to join me for a conversation all about penises and how to increase their sizes! Dr. Leonardo is the inventor of Growtox: Botox For Growers! Stream This Episode To Learn About: How To Eliminate Shrinkage With Botox How To Increase The Girth of Your Manhood Safe Procedures To Add Inches To Your Length And More! *About Our Guest: John Leonardo, MD, the President of Leonardo Medicine Professional Corporation (LMPC), is an American Board of Anesthesiology Diplomat and a Chronic Pain Management Specialist in Ontario, Canada. He has been in private practice for over 14 years and maintains a busy practice in both Ontario and New York State offering services in Aesthetic Medicine, Regenerative Medicine, Sexual Health, and Anti-Aging. Dr. Leonardo is the Medical Director of 4 different aesthetic practices throughout the Greater Toronto Area. Dr. Leonardo is also a Clinical Instructor with Empire Medical Training where he teaches courses in Botulinum Toxin, Dermal Fillers, and PRP Aesthetics in various locations such as Toronto, NYC, Chicago, and Las Vegas. Dr. Leonardo is a member of the Cellular Medicine Association. He has the distinction of being the first physician trained by Dr. Charles Runels, inventor of the Vampire Facelift, Priapus Shot, O-Shot, etc., in the Greater Toronto Area. Dr. Leonardo also has the distinction of being Dr. Alan Bauman's first Certified Hair Coach in Ontario. Dr. Bauman is arguably the top name in Hair Restoration. Dr. Leonardo is a coauthor with Drs. Jani van Loghem, Shino Bay Aguilera, Sabrina Fabi, Nabila Azib, and others for their forthcoming textbook, "Calcium Hydroxylapatite Soft Tissue Fillers Expert Treatment Techniques". *Connect With our Guest* Website: https://leonardomedicine.com/ Instagram: https://www.instagram.com/leonardomedicine/ Facebook: https://www.facebook.com/JLeonardoMD YouTube: https://www.youtube.com/channel/UCvDm-i5VBjnmCE97f9cQjdw

Dr. Don and Professor Ben talk about the risks from eating a cooked baked potato that has been wrapped in foil and promptly refrigerated. Dr. Don - not risky

Dr. Don and Professor Ben talk about the risks from eating a cooked baked potato that has been wrapped in foil and promptly refrigerated.Dr. Don - not risky

Today it's all about the topic of botulinum toxin for the treatment of the masticatory muscles.We will talk about:what is botulinum-toxin (Botox)?how does it work in masticatory muscles?for whom is it suitable?what are the side-effects?For more information, you can also go to our website:https://www.tmj.clinic

Why would anyone want to inject Botulinum Toxin in their face? Because it works! And, surprisingly, it's very safe! Knowing the history and science of Botox is helpful when deciding if this treatment is right for you. Botox is also used for much more than just wrinkles. From preventing excess sweating to correcting a neck condition in small children, Dr. Martin and Amy discuss how and why Botox has become so popular. Comments, questions, clarifications? Leave a voicemail (303) 630-9038 or email Amy@JasonMartinMD.com. Watch this episode on YouTube:  https://youtu.be/IXwG_1Zbihw Please rate and subscribe on Apple Podcasts, Stitcher, or wherever you listen to podcasts. Ratings and reviews are extremely helpful and greatly appreciated! Follow Beauty and the Surgeon: YouTube: Jason Martin MD > Beauty and the Surgeon Podcast Playlist Instagram: @beautyandthesurgeonpodcast Facebook: facebook.com/beautyandthesurgeonpodcast Website: beautyandthesurgeonpodcast.com Sponsored by: Let's Get Checked (trylgc.com/beauty code: beauty20)

Botox, Xeomin, and Dysport are the three most common botulinum toxins.   They're widely used for wrinkle reduction and they can also be used to decrease bands in the neck.  On this podcast, we explore the safety of botulinum toxins outside of the forehead.  

Episode 155 hosts Dr Jake and David, your co-hosts! They first summarise their Christmas break (or lack of it!) and the new challenges that they faced when reopening their clinics in 2022.  They share their plans for IA this year including: - Continuing IA's new and extremely popular mini series, 'The Injector Diaries' & 'Treatments and Regions Uncovered' - Three (yes, 3!) new mini series starting soon called 'Disasters & Solutions', 'Destination Clinics' & 'The Tox Talks' Dr Jake and David then get into the main topic of this episode - an in depth discussion about what aesthetic treatments they've both had including: - what skin care and products they use - Botulinum Toxin treatments: when they both started having Botox, what areas were treated and why - fillers (including both hyaluronic acid fillers and biostimulators): what areas of the face they have had treated and why - fat dissolving injections: Dr Jake's experience with Belkyra - cosmetic surgery: David talks about a procedure he had a few years ago   Follow IA on Instagram: www.instagram.com/insideaestheticspodcast Visit the IA website: www.insideaesthetics.com Subscribe to IA on Apple Podcasts: https://lnkd.in/gs-AzA Subscribe to IA on Spotify: https://lnkd.in/gpP88hW To contact Dr Jake & David: www.solo.to/insideaesthetics More about Dr Jake: www.solo.to/drjakesloane Follow Dr Jake on Instagram: www.instagram.com/drjakesloane Follow David on Instagram: www.instagram.com/david_insideaesthetics

Want a new you for the new year? The holidays are always a busy time for cosmetic procedures. Many people take advantage of unused vacation days, so they have plenty of time to heal from a procedure away from co-workers, and holiday bonuses can free up finances. Plus, it's exciting to think about starting a new year with a fresh look! Cosmetic procedures have been steadily rising thanks to the "Zoom Boom" caused by the pivot to virtual workplaces, and experts fully expect the trend to continue throughout the 2021 holidays and beyond. Web: www.newfaceny.com Follow: @newfaceny Doctors say breast augmentation and Brazilian Butt Lifts are the top surgeries being performed; however, liposuction, rhinoplasty, eyelid surgery and facelifts are also on the rise. Less invasive procedures like Botox injections also are skyrocketing. Experts say the Botulinum Toxin market jumped from a -8.6 percent slump in 2020 to a 4.7 percent increase this year, and it's still rising at an even faster pace. Lower facial nonsurgical procedures and lip treatments will continue to rise, and noses will stay strong. Body procedures are booming now that people are going out again. Top New York City plastic surgeon Dr. Richard Westreich offers the following tips for those considering cosmetic procedures: Tip 1: Make sure any doctor you schedule through a virtual visit allows you to cancel AFTER an in-person meeting for surgery. There is no substitute for face to face. Tip 2: Results over name recognition. Your outcome will not be better than what they post online. That's considered their best work. Tip 3: Don't rush. COVID-19 won't last forever, and you will have opportunities in the future that are different but workable. Make sure you're solid before moving on. Dr. Westreich says it's also very important that patients are vaccinated to stay healthy pre- and post-operation. “Although the average daily new COVID cases and deaths were recently declining, the new Delta variant mutations are far more dangerous. This has caused a recent uptick in test positivity rates and virus-related hospitalizations for the first time in months. Despite these alarming statistics, many are still opting to have these elective medical procedures and must take all of the necessary precautions.” More on Dr. Richard Westreich Dr. Richard Westreich graduated Magna Cum Laude with a B.A. in Biological Basis of Behavior, Neuroscience concentration in 1995 from the University of Pennsylvania. He completed his medical school training at the New York University School of Medicine in 1999 with an M.D. and Honors in Cell Biology Research. Dr. Westreich then did his post-graduate training in Facial Plastic Surgery and Otolaryngology at the prestigious Mount Sinai Hospital in New York City. He has been selected multiple times by Castle Connolly and New York magazine as one of the top doctors in facial plastic surgery. He is an assistant professor at SUNY Downstate Medical Center and is on staff at Lenox Hill and Mount Sinai Hospitals. He is a faculty member and teacher at a fellowship in Facial Plastic Surgery at Mount Sinai. His private practice is located on the Upper East Side of Manhattan, where he specializes in rhinoplasty, septoplasty, secondary and reconstructive rhinoplasty, facelifts, eyelid surgery and nonsurgical procedures. He can be seen regularly on several national news programs, including ABC, CBS, FOX and Newsmax. About the show: ► Website: http://www.ashsaidit.com ► Got Goli Gummies? https://go.goli.com/1loveash5 ► For $5 in ride credit, download the Lyft app using my referral link: https://www.lyft.com/ici/ASH584216 ► Want the ‘coldest' water? https://thecoldestwater.com/?ref=ashleybrown12 ► Become A Podcast Legend: http://ashsaidit.podcastersmastery.zaxaa.com/s/6543767021305 ► Review Us: https://itunes.apple.com/us/podcast/ash-said-it/id1144197789 ► SUBSCRIBE HERE: http://www.youtube.com/c/AshSaidItSuwanee ► Instagram: https://www.instagram.com/1loveash ► Facebook: https://www.facebook.com/ashsaidit ► Twitter: https://twitter.com/1loveAsh ► Blog: http://www.ashsaidit.com/blog ► Pinterest: https://www.pinterest.com/1LoveAsh/ #atlanta #ashsaidit #ashsaidthat #ashblogsit #ashsaidit® Ash Brown is a gifted American producer, blogger, speaker, media personality and event emcee. The blog on AshSaidit.com showcases exclusive event invites, product reviews and so much more. Her motivational podcast "Ash Said It Daily" is available on major media platforms such as iTunes, Spotify, iHeart Radio & Google Podcasts. This program has over half a million streams worldwide. She uses these mediums to motivate & encourage her audience in the most powerful way. She keeps it real!

Want a new you for the new year? The holidays are always a busy time for cosmetic procedures. Many people take advantage of unused vacation days, so they have plenty of time to heal from a procedure away from co-workers, and holiday bonuses can free up finances. Plus, it's exciting to think about starting a new year with a fresh look! Cosmetic procedures have been steadily rising thanks to the "Zoom Boom" caused by the pivot to virtual workplaces, and experts fully expect the trend to continue throughout the 2021 holidays and beyond. Web: www.newfaceny.com Follow: @newfaceny Doctors say breast augmentation and Brazilian Butt Lifts are the top surgeries being performed; however, liposuction, rhinoplasty, eyelid surgery and facelifts are also on the rise. Less invasive procedures like Botox injections also are skyrocketing. Experts say the Botulinum Toxin market jumped from a -8.6 percent slump in 2020 to a 4.7 percent increase this year, and it's still rising at an even faster pace. Lower facial nonsurgical procedures and lip treatments will continue to rise, and noses will stay strong. Body procedures are booming now that people are going out again. Top New York City plastic surgeon Dr. Richard Westreich offers the following tips for those considering cosmetic procedures: Tip 1: Make sure any doctor you schedule through a virtual visit allows you to cancel AFTER an in-person meeting for surgery. There is no substitute for face to face. Tip 2: Results over name recognition. Your outcome will not be better than what they post online. That's considered their best work. Tip 3: Don't rush. COVID-19 won't last forever, and you will have opportunities in the future that are different but workable. Make sure you're solid before moving on. Dr. Westreich says it's also very important that patients are vaccinated to stay healthy pre- and post-operation. “Although the average daily new COVID cases and deaths were recently declining, the new Delta variant mutations are far more dangerous. This has caused a recent uptick in test positivity rates and virus-related hospitalizations for the first time in months. Despite these alarming statistics, many are still opting to have these elective medical procedures and must take all of the necessary precautions.” More on Dr. Richard Westreich Dr. Richard Westreich graduated Magna Cum Laude with a B.A. in Biological Basis of Behavior, Neuroscience concentration in 1995 from the University of Pennsylvania. He completed his medical school training at the New York University School of Medicine in 1999 with an M.D. and Honors in Cell Biology Research. Dr. Westreich then did his post-graduate training in Facial Plastic Surgery and Otolaryngology at the prestigious Mount Sinai Hospital in New York City. He has been selected multiple times by Castle Connolly and New York magazine as one of the top doctors in facial plastic surgery. He is an assistant professor at SUNY Downstate Medical Center and is on staff at Lenox Hill and Mount Sinai Hospitals. He is a faculty member and teacher at a fellowship in Facial Plastic Surgery at Mount Sinai. His private practice is located on the Upper East Side of Manhattan, where he specializes in rhinoplasty, septoplasty, secondary and reconstructive rhinoplasty, facelifts, eyelid surgery and nonsurgical procedures. He can be seen regularly on several national news programs, including ABC, CBS, FOX and Newsmax. About the show: ► Website: http://www.ashsaidit.com ► Got Goli Gummies? https://go.goli.com/1loveash5 ► For $5 in ride credit, download the Lyft app using my referral link: https://www.lyft.com/ici/ASH584216 ► Want the ‘coldest' water? https://thecoldestwater.com/?ref=ashleybrown12 ► Become A Podcast Legend: http://ashsaidit.podcastersmastery.zaxaa.com/s/6543767021305 ► Review Us: https://itunes.apple.com/us/podcast/ash-said-it/id1144197789 ► SUBSCRIBE HERE: http://www.youtube.com/c/AshSaidItSuwanee ► Instagram: https://www.instagram.com/1loveash ► Facebook: https://www.facebook.com/ashsaidit ► Twitter: https://twitter.com/1loveAsh ► Blog: http://www.ashsaidit.com/blog ► Pinterest: https://www.pinterest.com/1LoveAsh/ #atlanta #ashsaidit #ashsaidthat #ashblogsit #ashsaidit® Ash Brown is a gifted American producer, blogger, speaker, media personality and event emcee. The blog on AshSaidit.com showcases exclusive event invites, product reviews and so much more. Her motivational podcast "Ash Said It Daily" is available on major media platforms such as iTunes, Spotify, iHeart Radio & Google Podcasts. This program has over half a million streams worldwide. She uses these mediums to motivate & encourage her audience in the most powerful way. She keeps it real!

Dr. Glenn Clark discusses the use of botulinum toxin in patients with persistent orofacial pain. This lecture is designed to familiarize dentists with the scientific evidence that underlies the use and abuse of Botulinum Toxin for orofacial pain disorders and motor disorders. Dr. Clark also discusses the various injection protocols and when they are indicated.

Moderator:       Ekene A. Enemchukwu, MD, MPH Speaker:              Michael J. Kennelly, MD, FACS 

Prof Prokar Dasgupta is the Foundation Professor of Surgery for King's Health Partners. Professor Dasgupta pioneered robotic surgery in the UK, and leads on surgical simulation both nationally and internationally. He has an extensive research portfolio and is credited with describing an innovative technique of injecting Botulinum Toxin (botox) for the treatment of an overactive bladder which has helped millions of patients worldwide (Dasgupta technique). In this episode we ask him about: His career Urology Research Advice for medical students and doctors   For comments, collaboration or feedback, contact us via email or Twitter. Email: medspirepodcast@gmail.com Twitter: @medspirepodcast

Botulinum toxin and surgical intervention in children and adolescents with cerebral palsy: who, when and why do we treat?Jane Valentine, Sue-Anne Davidson, Natasha Bear, Eve Blair, Roslyn Ward, Ashleigh Thornton , Katherine Stannage, Linda Watson, David Forbes, Catherine Elliott PMID: 31415723DOI: 10.1080/09638288.2019.1644381AbstractIntroduction: This audit aimed to increase understanding of the long-term outcomes of evidence-based medical and surgical interventions to improve gross motor function in children and adolescents with Cerebral Palsy.Methods: Retrospective audit of a birth cohort (2000-2009) attending a tertiary service in Western Australia.Results: The cohort comprises 771 patients aged 8 to 17 years. Percentage of children receiving no Botulinum Toxin treatments in each Gross Motor Functional Classification System level was: I: 40%, II: 26%, III: 33%, IV: 28% and V: 46%. Of the total cohort, 53% of children received 4 or less Botulinum Toxin treatments and 3.7% received more than 20 treatments. Statistically significant difference in the rate of use of Botulinum Toxin pre and post-surgery (p < 0.001) was documented. Children levels IV and V had 5 times the odds of surgery compared to children levels I-III (Odds Ratio 5.2, 95% Confidence Interval 3.5 to 7.8, p < 0.001). For 578 (75%) of participants the last recorded level was the same as the first.Conclusion: This audit documents medical intervention by age and Gross Motor Functional Classification System level in a large cohort of children with cerebral palsy over time and confirms stability of the level in the majority.IMPLICATIONS FOR REHABILITATIONThe information from this audit may be of use in discussions with families regarding the timing and use of Botulinum toxin and surgical intervention for motor function in children and adolescents with Cerebral Palsy.Long term use of Botulinum Toxin within an integrated evidence-based clinical program is not associated with loss of gross motor function in the long term as evidenced by the maintenance of Gross Motor Functional Classification System stability.Keywords: Cerebral palsy; botulinum toxin; children; gross motor function classification; orthopedic surgery.

To obtain credit – Click Here For more information – Click Here

To obtain credit – Click Here For more information – Click Here

"How I Do It: Botulinum Toxin for Cervical Dystonia," by Shalini Shah, MD, Vice-Chair and Enterprise Director Pain Services, Associate Clinical Professor, Department of Anesthesiology & Perioperative Care, University of California Irvine, Orange, California. From ASRA News, November 2020. See original article at www.asra.com/asra-news for figures and references. This material is copyrighted.    

WARNING! It goes without saying, but there will be talk about needles in this episode, so if you have a phobia, maybe skip this one. Sidney shares her experience with injectables and explains to Kenzie and Ginny that there are several different kinds. Kenzie talks about her fully unfounded fear of Botox and Ginny wonders if baddies have ever tried to harm people with Botulinum Toxin. Oh! And Kenzie didn't have to split the episode into multi-parters for the first time in a while! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/technicallyanadult/support

In this episode Dr. Karen Raphael shares her research on the areas of psychological comorbidities in chronic pain, the relationship of sleep bruxism and temporomandibular disorders as well as the use of botulinum toxin in the management of orofacial pain conditions. Dr. Karen Raphael is a PhD-level psychologist and epidemiologist whose work over the last 35 years has focused on the role of psychosocial and stress-related factors in medically unexplained pain. As she was completing postdoctoral training in psychiatric epidemiology at Columbia University, she met Dr. Joseph Marbach, an orofacial pain specialist and renowned clinical researcher. Most of their close collaboration for a dozen years until his passing in 2001 involved studying processes underlying chronic temporomandibular disorders. After serving on faculty at Columbia University (in Public Health, Psychiatry and the Dental School), she continued research on orofacial pain and other forms of medically unexplained pain at Rutgers/Newark Medical and Dental Schools, where she was promoted to Professor. Her work broadened to encompass areas ranging from translational pain psychophysics to pain epidemiology. She continued methodologically-driven work on biases in both patient reporting and clinical observation. Since 2009, Dr. Raphael has held a primary appointment at New York University College of Dentistry, serving as Professor in the Department of Oral & Maxillofacial Pathology, Radiology and Medicine. Her research on stress and muscle activity expanded to include use of polysomnographic studies and awake stress-reactivity studies to examine the role of bruxism in temporomandibular disorders. Dr. Raphael's writings inspired an international consensus committee of orofacial pain experts to reconsider whether bruxism is a disorder requiring treatment. In addition to serving as Principal Investigator on a dozen grants funded primarily by the NIH, Dr. Raphael has published approximately 100 peer-reviewed manuscripts and has served on numerous editorial boards and grant review committees. Her most recent funded research has examined potential bone-related risk from use of Botulinum Toxin to treat temporomandibular disorders.

Tandkødssmil eller “gummy smile” er ofte et kæmpe problem for dem, der har det. Det ekstra store smil med blottet tandkød hæmmer i sociale sammenhænge, og vi hører tit patienter fortælle, at de helst helt undgår at smile blandt fremmede.Men med to injektioner med stoffet Botulinum Toxin kan du vinke farvel til tandkødssmilet. Lyt, når kosmetisk sygeplejerske hos AK Nygart i Århus, Helle Boisen, fortæller mere om behandlingen.Vil du gerne vide mere?Læs mere om behandling af tandkødssmil med Botulinum ToxinSe priserne.Book en tid efter Covid-19 ved at sende os en mail på info@nygart.dkForundersøgelser til behandling af tandkødssmil med Botulinum Toxin er gratis.Hvor kan du finde AK Nygart?HjemmesideFacebookInstagramYoutube

This episode covers the basics of the mechanism of action of botulinum type A toxin

I denne episode af Skønhedsguiden skal vi sammen med kosmetisk sygeplejerske hos AK Nygart, Channe Berthelsen, tale om brynløft med Botox.Mange forbinder måske alt der hedder løft med kirurgi. Men med minimale injektionsbehandlinger, såsom Restylane filler og Botulinum Toxin, kan vi give forskellige dele af ansigtet et løft.Dette gælder også øjenbrynene, som vi kan give et lille løft. Ved at injicere Botulinum Toxin, der midlertidigt lammer nogle muskler, kan vi aktivere andre muskler, som kan løfte øjenbrynene.Hvordan det helt præcis går til, og hvad du kan forvente, kan du høre mere om i episoden her.Vil du gerne vide mere?Læs mere om brynløft med botulinum toxin.Book en tid på 70275757 eller online.Forundersøgelser til behandling med Botulinum Toxin er gratis.Hvor kan du finde AK Nygart?HjemmesideFacebookInstagramYoutube

Botox can benefit people with neurological disorders. Dr. Parul Aneja, neurologist, discusses how botox is used in neurology.

Botox is the most popular procedure in all of plastic surgery. With over 6 and a half million people having Botox last year, it is incredibly safe and incredibly effective. On today's show, we discuss everything about Botox, from the injection technique, to its benefits, and its excellent safety profile. Tune in!

Dr. Frevert studied chemistry at the Philipps-University, Marburg (Germany) where he got his PhD in biochemistry. In his thesis work, he investigated the biosynthesis of plant organelles and enzymes of fatty acid metabolism. After a postdoctoral fellowship at the University of California, Berkeley (USA), he started his career in 1983 at the Battelle Institute in Frankfurt (Germany). Between 1995 and 2006, Dr. Frevert was Project Manager for biochemical projects and later Chief Scientific Officer of BioteCon Therapeutics GmbH, and during this time he started a cooperation with Merz Pharmaceuticals to develop the pure clostridium botulinum neurotoxin as a pharmaceutical which was licensed as Xeomin in 2005 in Germany for the treatment of cervical dystonia and blepharospasm and in 2009 for the treatment of glabellar frown lines. In 2007 he was employed by Merz Pharmaceuticals as Head of Botulinum Toxin Research and was responsible for the development of next generation botulinum toxin products with new pharmacological properties. In 2017 he retired and is now working as a consultant for Merz Pharmaceuticals.

Dr. Frevert studied chemistry at the Philipps-University, Marburg (Germany) where he got his PhD in biochemistry. In his thesis work, he investigated the biosynthesis of plant organelles and enzymes of fatty acid metabolism. After a postdoctoral fellowship at the University of California, Berkeley (USA), he started his career in 1983 at the Battelle Institute in Frankfurt (Germany). Between 1995 and 2006, Dr. Frevert was Project Manager for biochemical projects and later Chief Scientific Officer of BioteCon Therapeutics GmbH, and during this time he started a cooperation with Merz Pharmaceuticals to develop the pure clostridium botulinum neurotoxin as a pharmaceutical which was licensed as Xeomin in 2005 in Germany for the treatment of cervical dystonia and blepharospasm and in 2009 for the treatment of glabellar frown lines.  In 2007 he was employed by Merz Pharmaceuticals as Head of Botulinum Toxin Research and was responsible for the development of next generation botulinum toxin products with new pharmacological properties. In 2017 he retired and is now working as a consultant for Merz Pharmaceuticals. 

Michelle Magid, MD, conducts a Masterclass lecture on botulinum toxin for depression from the Psychopharmacology Update in Cincinnati. The meeting was sponsored by Global Academy for Medical Education and Current Psychiatry. Dr. Magid is associate professor University of Texas in Austin, and associate professor of Texas A&M University in College Station. She disclosed serving as a speaker for Ipsen, maker of Dysport (abobotulinumtoxinA, or ABO), and as a consultant for Allergan, maker of Botox (onabotulinumtoxinA). *  *  *   Help us make this podcast better! Please take this short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019  *  *  *   This week in psychiatry: Conduct disorder in girls gets overdue research attention by Bruce Jancin The physiological and emotion-procession abnormalities that underpin conduct disorder in teen girls are essentially the same as in teen boys. however, the clinical presentation of conduct disorder in the two groups is often different.  What we know about botulinum toxin Botulinum toxin is the product of Clostridium botulinum. The neurotoxin inhibits the release of acetylcholine, resulting in flaccid muscle relaxation. Its clinical use started in 1989 to treat strabismus (crossed eyes) and blepharospasm, a dystonic reaction in the eyes. Currently, botulinum is a Food and Drug Administration–approved treatment of chronic migraine in adults. For use in depression, 30-40 units of botulinum toxin is injected into the glabellar region of the face (the forehead). A purported mechanism of action of botulism for depression includes the “facial feedback hypothesis,” in which the activation of muscles of facial expression, consciously or unconsciously, influences emotions. Botulinum toxin for depression is an off-label treatment with four case series, five randomized, controlled studies, and a phase 2 trial by supported by Allergan. New findings on use of botulinum toxin for depression  Magid and colleagues completed a pooled analysis of three randomized, controlled trials totaling 134 patients. Fifty-nine people were included in the botulinum toxin intervention group with a Beck Depression Inventory (BDI) score of 29, and 75 individuals in the placebo group with BDI of 26. In each group, 64% of patients were continued on other medications for depression, and the groups had similar histories of long-standing depression. In the botulinum toxin group, 52% had a response to the intervention, with an at least 50% reduction in their baseline depression scores, compared with a limited response in the placebo group. In the pooled analysis, Dr. Magid’s group analyzed whether the cosmetic effect of botulinum toxin could be a confounding factor. The investigators ruled out that effect by using a subanalysis to evaluate whether the decrease in wrinkles correlated with decrease in depression, and it did not. Allergan moved forward with a phase 2 proof-of-concept trial; the results were mixed. The endpoint was response rate in Montgomery-Åsberg Depression Rating Scale (MADRS) at week 6. With a 30-unit Botox dose, there was a statistically significant decrease in MADRS at week 9, but not at week 6. There was no statistically significant divergence in data between the placebo and intervention group with the 50-unit dose. Given the response rate at week 9, Allergan is proceeding with a phase 3 trial. The cost is about $400 per treatment, and the treatment is given three to four times a year, which makes the cost comparable to that of other psychopharmacologic treatments. Adverse events are mild and include headache and local site irritation. In the current studies, botulinum treatment has been used as both monotherapy and augmentation; however, there are not enough data to know whether one is more effective than the other. In conclusion, burgeoning psychopharmacology research on treatments such as botulinum toxin for depression and novel medications, such as esketamine and brexanolone, broaden our understanding of the etiology of depression. This research is generating novel modes of treatment that will help more patients with refractory illness. References Magid M et al. Treating depression with botulinum toxin: A pooled analysis of randomized controlled trials. Psychopharmacology. 2015 Sep;48(6):205-10. Magid M et al. Treatment of major depressive disorder using botulinum toxin: A 24-week randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2014 Aug;75(8):837-44.  *  *  *   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgePsych  

Dr. Schaefer discusses with Dr. Kamel the role of botulinum toxin in the treatment of refractory upper limb tremor, and his center's tailored approach to provide relief for these patients.

Did you know there's a brand new neurotoxin poised to come to market?  Did you know that Allergan snapped up the small biotech company for $195M as soon as their phase 2 clinical trial results were released?  Join us in this episode as we explore the personality and behavior of the latest botulinum toxin to join the Botox Party!   https://www.marketwatch.com/story/allergan-will-buy-neurotoxin-company-bonti-for-195-mln-2018-09-14 https://www.businesswire.com/news/home/20180802005452/en/Bonti-Announces-Successful-Completion-Phase-2a-Scar https://www.businesswire.com/news/home/20180509005700/en/Bonti-Announces-Start-LANTERN-2-Phase-2-Clinical

In this episode of Aesthetics Mastery podcast, we're putting YOUR questions around Botox complications to Dr Tim. #AskDrTim1. When should you NOT treat heavy lids? (3m15s)2. How to correct "Spock brow"? (9m30s)3. Why is there a recommended dose per area, but then more can be added at top up? (12m20s)4. Should we NOT be injecting Botox into over 65s? (14m50s)5. Are there typical reasons why clients aren't satisfied and what you can do at the top up appointment that would be helpful and/or avoiding the issue in the first place (17m15s)You can find the video on preventing Eyelid Ptosis here: https://youtu.be/pvcbJLEkpaIIf you have any questions for Dr Tim, just use #AskDrTim to be answered either on the podcast or via a Facebook Live on the Dr Tim page: https://www.facebook.com/doctortimpearce/

This week, we've invited Dr Ahmed El Houssieny to talk through the "Botulinum Toxin in Aesthetic Medicine: Myths and Realities" paper from The Journal for the Medical Society for Dermatologic Surgery.

Housekeeping While I'm typically an Android guy, I must say I have been impressed by the quality of the service I've gotten from the Apple Podcasts team. They've been responsive and helpful whenever I've had to work with them. And now, they are even faster. Generally it takes up to 2 weeks to get a new podcast in the Apple Podcasts store. It took them just 6 hours to add Strokecast. Please leave a rating and/or review for the Strokecast here. Being in the Apple Podcasts store means you can easily subscribe from an iPhone or iPad and never miss an episode. It also means that most other popular podcast apps for the Android or Samsung phone platforms also know about the Strokecast. You can subscribe in pretty much whatever app you use to listen to podcasts. Strokecast is also on Spotify. If you use Spotify on your mobile device, just search for Strokecast and it will pop right up. Tone and Spasticity  Infomercials and popular media talk about how the latest diet or the newest bow-nordi-master machine will help you build muscle and get toned. Tone in muscles is actually a bad thing in the PT/OT world. A muscle with tone is basically flexed all the time. It's contracted and in a state of tension. When my fingers curl up in a tight ball and won't release, it's because I have too much muscle tone. It my arm gets toned, that mean the muscles tighten and it curls up, useless. Tone in my legs will prevent me from bending or unbending my hip, knee, or ankle. Or cause my toes to curl up in my shoe. A muscle with tone is useless. One goal of the exercises I do with PT is to prevent tone from setting in. Working on range of motion, joint flexibility, and muscle strengthening prevents tone. What most people think of as tone is probably definition. They want to see the muscles. We often make our muscles visible be flexing them. Tone is when your muscles essentially flex themselves and then stay that way, even when you want them to stop. Imagine flexing your bicep and then keeping it flexed all day as you go about your business. That's why you don't want tone in your muscles. Treatment There are a number of ways to address tone. Some popular ones include: Movement therapy Stretching Tiring it out Massage Relaxation/mindfulness Accupuncture There are also medicinal solutions. Baclofen is a pill that can reduce tone. It can affect the whole body, though, and one of the main side affects is fatigue. Since many stroke survivors are already dealing with fatigue, this can be a challenge. Of course, not everyone experiences the side affects, and it can be a great solution. Medtronic also makes a Baclofen pump. A surgeon implants it in the abdomen and runs a tube into the spine so the pump continually deploys small amounts of Baclofen into the spinal fluid. It can be a little more targeted than the pill, and because the dosage is much lower it has few side affects. The dosage is lower because unlike a pill, it doesn't have to make its way through the digestive system into the circulatory system, and then into the nervous system. On the other hand...surgery. Botox is also an effective treatment.  Based on Botulinum Toxin, Botox is used to treat both wrinkles and tone. The director uses electrodes to monitor the firing of nerves in a muscle, and then injects Botox directly into the toned muscle to put many of the nerves to sleep for a few months. This relaxes the toned muscles and gives the other muscles a chance to recover. Hack of the Week It took me a while to figure out how to take my shirt off, and not just because people scream when I do. It simply wasn't a skill we needed to focus on the hospital. Here is my current process. Reach straight back over my head with my good hand -- follow the path of an imaginary Mohawk. Grab the back of my shirt collar. Pull that over my head. Take my right sleeve in mouth and pull the sleeve off my right arm. Grab the left sleeve with my right hand to remove that. This process also works with jackets and hoodies. It works best with long sleeves, but my short-sleeved t-shirts work out okay, too. I just skip the sleeve biting there. Where do we go from here? Do you have any tips or stories you'd like to share on a future episode? Email me at Bill@strokecast.com. I'd love to hear from stroke survivors, caretakers, medical professionals, and more. Share your thoughts on Episode 3 in the comments below. On the Apple platform , please leave a rating or review. Share this episode with anyone who might be interested. Don't get best...get better.

How effective is the use of botox for brow lift? Found out here...paper below El-Khoury JS, Jabbour SF, Awaida CJ, Rayess YA, Kechichian EG, Nasr MW. The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial. Plast Reconstr Surg. 2018 Jan;141(1):75-78

In a special “Cosmetic Masters Edition” of the Award-winning PRS Journal Club Podcast, 2018 Resident Ambassadors to the PRS Editorial Board -M. Shuja Shafqat MD, Chad Purnell MD, and Jordan Frey MD- and special guest moderator Rod Rohrich MD, Editor-in-Chief of Plastic and Reconstructive Surgery, discuss the following cosmetic articles from the October 2017 issue: “Transparency in Functional Rhinoplasty: Benefits of Routine Prospective Outcome Measurements in a Tertiary Referral Center” by Datema, van Zijl, van der Poel, et al. “Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Midface” by de Maio, DeBoulle, Braz, and Rohrich. "Extended Alar Contour Grafts: An Evolution of the Lateral Crural Strut Graft Technique in Rhinoplasty” by Cochran and Sieber.

Dr Patricia Ogilvie - Botulinum Toxin Beyond The Face by Trish Hammond

Yes, we have harnessed the power of paralysis. Botulinum toxin, which is produced by a lethal bacterium, Clostridium botulinum, has been bottled and sold to neurologists for decades. And you know this because you've seen people who received Botox to relax their facial muscles. In this week's installment, Dr. Anh-Thu Vu discusses how neurologists utilize this neurotoxic agent. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. The content in this episode was vetted and approved by Anh-Thu Vu. REFERENCES 1. Arnon SS, Schechter R, Inglesby T V, et al. Botulinum toxin as a biological weapon: medical and public health management. JAMA. 2001;285(8):1059-1070. 2. Thenganatt MA, Fahn S. Botulinum toxin for the treatment of movement disorders. Curr Neurol Neurosci Rep. 2012;12(4):399-409. doi:10.1007/s11910-012-0286-3. 3. Aurora SK, Winner P, Freeman MC, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358-1373. doi:10.1111/j.1526-4610.2011.01990.x. 4. Dauer WT, Burke RE, Greene P, Fahn S. Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia. Brain. 1998;121 (Pt 4):547-560. 5. Karp BI. Botulinum toxin treatment of occupational and focal hand dystonia. Mov Disord. 2004;19 Suppl 8:S116-S119. doi:10.1002/mds.20025. 6. Elia AE, Filippini G, Calandrella D, Albanese A. Botulinum neurotoxins for post-stroke spasticity in adults: a systematic review. Mov Disord. 2009;24(6):801-812. doi:10.1002/mds.22452. 7. Naumann M, Dressler D, Hallett M, et al. Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon. 2013;67:141-152. doi:10.1016/j.toxicon.2012.10.020. 8. Lotia M, Jankovic J. Botulinum Toxin for the Treatment of Tremor and Tics. Semin Neurol. 2016;36(1):54-63. doi:10.1055/s-0035-1571217.

This study examined the effect of botulinum toxin upon plantar fasciitis through a randomized, controlled, and blinded trial. Between 2012 and 2015, 50 patients presented with plantar fasciitis. Twenty-five patients each randomly received an IncobotulinumtoxinA (IBTA) or saline injection of their affected foot. Pre- and postinjection function and pain were graded with the Foot and Ankle Ability Measures (FAAM) and visual analog scale (VAS), respectively. All 50 study patients who randomly received either placebo or IBTA presented at 6 and 12 months after injection. Compared with placebo saline injection, using IBTA to treat plantar fasciitis resulted in significantly better improvement in foot function and pain. IBTA also lessened the need for operative treatment of plantar fasciitis.   To view the article, click here.

Talking Urology Episode 4 - Guest: Prof. Victor Nitti

Botulinum Toxin – scary sounding name isn’t it – but you will have heard it plenty of times as Botox. You may also have heard it being referred to as a neuromodulator. Even though it has been around for many years as a cosmetic procedure, there are still many mysteries and confusion surrounding its use and benefits, which is amazing … Read more about this episode...

Interview with Haley B. Naik, MD, MHSc, author of Efficacy of Intralesional Botulinum Toxin A for Treatment of Painful Cutaneous Leiomyomas: A Randomized Clinical Trial

On this episode of The Poisoncast learn how the world’s most deadly toxin, botulinum toxin from the bacteria Clostridium botulinum, is also surprisingly versatile.

Interview with Siba Haykal, MD, PhD, author of The Role of Botulinum Toxin A in the Establishment of Symmetry in Pediatric Paralysis of the Lower Lip

A tour of the Earth's biggest, oldest, and most lethal living creatures.

Introduction: Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity. Unfortunately, most therapeutic approaches remain clinically unsatisfactory. Recently, injections with botulinum toxin A (BTA) were proposed for the treatment of established keloids in a clinical trial. In this study, we aimed to verify the effects of intralesional BTA for the treatment of therapy-resistant keloids using objective measurements. In addition, the underlying molecular mechanisms were investigated using cultured keloid-derived fibroblasts. Materials and Methods: Four patients received BTA (doses varying from 70 to 140 Speywood units per session) injected directly into their keloids every 2 months for up to 6 months. Differences in height and volume were evaluated clinically and measured with a 3-D optical profiling system. Keloid-derived fibroblasts were treated with different concentrations of BTA, and expression of collagen (COL)1A1, COL1A2, COL3A1, TGF-beta 1, TGF-beta 2, TGF-beta 3, fibronectin-1, laminin-beta 2, and alpha-SMA was determined by real-time quantitative PCR. MTT and BrdU assays were used to analyze the effects of BTA on fibroblast proliferation and metabolism. Results: Intralesional administration of BTA did not result in regression of keloid tissue. No differences in expression of ECM markers, collagen synthesis, or TGF-beta could be observed after BTA treatment of keloid fibroblasts. In addition, cell proliferation and metabolism of keloid fibroblasts was not affected by BTA treatment. Conclusion: The suggested clinical efficiency of intralesional BTA for the therapy of existent keloids could not be confirmed in this study. Based on our data, the potential mechanisms of action of BTA on keloid-derived fibroblasts remain unclear. Copyright (C) 2012 S. Karger AG, Basel

In this podcast, Dr Peter Baxter speaks to Dr Stephen O'Flaherty (Kids Rehab, The Children's Hospital at Westmead, Westmead, NSW, Australia ) about the article he co-authored in the February issue of Developmental Medicine & Child Neurology, entitled ‘Adverse events and health status following botulinum toxin type A injections in children with cerebral palsy', and with Professor Kerr Graham (Professor of Orthopaedic Surgery, University of Melbourne, Royal Children's Hospital, Melbourne, Australia). Read the paper here: http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2010.03814.x/abstract

Host: Anthony Alessi, MD Guest: David Simpson, MD 14 million Americans suffer migraine headaches everyday. Many go untreated and many who are treated continue to have headaches. An old drug may offer a new way to treat migraines, with the FDA approval of botulinum toxin injections for severe chronic migraine. Dr. David Simpson, professor of neurology at Mount Sinai School of Medicine in New York City and director of the clinical neurophysiology lab at Mount Sinai Hospital, joins host Dr. Anthony Alessi to discuss what patients qualify for this treatment, problems and risks associated with taking the injections, and the controversial results of the clinical trials for this treatment, including the PREEMPT 1 and 2 trials. Produced in cooperation with:

Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection was performed in 56 patients with idiopathic OAB. Patients were followed up for 6 months concerning side effects and patients' satisfaction. Results: Different types of side effects were assessed such as dry mouth (19.6%), arm weakness (8.9%), eyelid weakness (8.9%), leg weakness (7.1%), torso weakness (5.4%), impaired vision (5.4%) and dysphagia (5.4%). In all cases, symptoms were mild and transient. Urological complications such as gross hematuria (17.9%), acute urinary retention (8.9%) and acute urinary tract infection (7.1%) were noticed. In all cases, acute urinary retention was transient and treated with temporary intermittent self-catheterization. There was no statistically significant correlation between dosage and observed side effects. Patients' satisfaction rate was high (71.4%). Conclusion: Intradetrusor injection of botulinum toxin was associated with a high rate of neurourological side effects. In general, side effects were transient, mild and did not require special treatment. Copyright (C) 2010 S. Karger AG, Basel

Audio podcast from the 1st Annual SDPA Summer Dermatology Conference in Chicago, IL. This was “Regional Uses of Botulinum Toxin and Soft Tissue Augmentation” with Murad Alam, MD. This session is also available as a download on iTunes through the dermcast podcast page*. Click here to visit the page on [...]

Thu, 8 Oct 2009 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/11138/ https://edoc.ub.uni-muenchen.de/11138/1/Hasse_Anette.pdf Hasse, Anette

Aim: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. Methods: Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport (R)). The primary endpoint was reduction in number of migraine attacks up to week 8 and between weeks 8 and 12 after injection. Patient diaries were used to record secondary endpoints, including frequency, severity and duration of migraine attacks. Results: There was a mean reduction of 0.54 and 0.94 attacks/month with placebo and BoNT-A, respectively, and absolute attack count was less in the verum group (3.6 vs. 4.2 attacks/month), but this was not statistically significant. The patients' global assessment of efficacy was significantly better than placebo in the high-dose group (p = 0.02) but no effects were seen for the other secondary efficacy parameters. Conclusion: Our study showed a trend towards a reduced attack rate with verum but did not show any statistically significant efficacy of BoNT-A in the prophylactic treatment of migraine. Copyright (C) 2009 S. Karger AG, Basel

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7085/1/botulinum_toxin_paralysis_of_the_orbicularis_oculi_muscle_7085.pdf Evinger, C.; Porter, J. D.; Horn, Anja K. E. ddc:610, Medizin