Podcasts about ascorbic

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Berries are one of the most easily accessible, nutrient-packed plant foods we can eat. You may know that berries are good for you, but do you know what makes them so nutritious? Tina and Leah talk about common and exotic berries and tell you what's inside berries that makes them so awesome! You may even learn a few new plants you didn't know were technically berries!Bananas are berries! About Goji BerriesInformation on Sea BuckthornThe health effects of berry bioactive compounds Antioxidant effects of berriesThe fruit that is literally called Miracle FruitSupport the showOur website:https://www.thecancerpod.com Have an idea or question? Email us: thecancerpod@gmail.comJoin our growing community, we are @TheCancerPod on: Instagram Twitter Facebook LinkedIn THANK YOU for listening!

I loved this conversation! Tune in to hear me talk about pumping up the iron for optimal energy as a guest on the Turned ON- Wild, Free and Sexy in Midlife podcast with Penny Van Der Sluys.   Often when your iron levels are low, life can feel flat and like you're running on empty. For many women, levels can be surprisingly difficult to manage, and the best ways to manage it can be uncertain.  In this episode I share about my experience with iron deficiency and how it led me to dive deeper into what was the underlying cause. You'll hear more about: What is anaemia The symptoms of low iron An essential ingredient we need to absorb iron. Why iron supplements may not work for you. Gut health, pre & probiotic foods Foods that damage your gut health The role vitamin C plays in absorption (it's not what we've been led to believe). Ascorbic acid vs wholefood vitamin C. Blood tests and what to ask for. Getting a copy of your blood test results The importance of getting to the root of a symptom Getting interested in your medical history And more…   More about Penny:   Penny Van Der Sluys is a Feminine Empowerment coach and Pleasure Activist, who encourages womento live a turned on life, prioritise pleasure, play and passion, and reconnect with their feminine power.      Connect with Penny: Podcast: Turned On - Wild, free & Sexy in your midlife     penny@pennyvandersluys.com   pennyvandersluys.com   Wanna know more? Listen in! Haven't subscribed to the podcast yet? Subscribe HERE and never miss an episode. Connect with Kate: Website: www.MindMovementHealth.com.au Facebook: http://www.facebook.com/MindMovementHealth Instagram: http://instagram.com/MindMovementHealth  

In this episode, I invite Kate Boyle back to explore a topic that you've most likely heard about, possibly even managed yourself. Low iron levels. Iron has a vital role in living a turned on life. When your iron levels are low, life can feel flat and like you're running on empty. For many women, levels can be surprisingly difficult to manage, and the best ways to manage it can be uncertain. For example, should you supplement your diet with iron? When are iron infusions the way to go? Do we know what's really causing it? Or why we have to contend with low levels, even when we increase our iron intake? Tune in to hear Kate share about her experience with iron deficiency and how it led her to dive deeper into what was the underlying cause. You'll hear us discuss: What is anemia What are symptoms of low iron? An essential ingredient we need to absorb iron. Why iron supplements may not work for you. Gut health, pre & probiotic foods Foods that damage your gut health The role vitamin C plays in absorption (it's not what we've been led to believe). Ascorbic acid vs wholefood vitamin C. Blood tests and what to ask for. Getting a copy of your blood test results The importance of getting to the root of a symptom Getting interested in your medical history For more information and to check out her online Health and Movement Membership please head to ⁠www.MindMovementHealth.com.au Follow her on social at; ⁠https://www.facebook.com/MindMovementHealth⁠ ⁠https://www.instagram.com/MindMovementHealth⁠ ⁠https://www.linkedin.com/in/kate-boyle-b2897ba1/⁠ ⁠https://www.youtube.com/channel/UC9yMsWZmU7jNr7KyXWqj9iA

Today, I am blessed to have here with me Morley Robbins. He is the creator and founder of The Root Cause Protocol and the Magnesium Advocacy Group. Morley received his BA in Biology from Denison University in Ohio and holds an MBA from George Washington University in healthcare administration. Morley has trained in wellness coaching, nutritional counseling, and functional diagnostic nutrition. This episode originally aired in April 2022. He is also known as the Magnesium Man due to his extensive research into and understanding of magnesium's role in the body. Morley's research saw him deciphering the intricate relationship between magnesium, iron, copper, and calcium as a way to free ourselves from illness and dis-ease. As a certified health coach with expertise in Hair Tissue Mineral Analysis (HTMA), Morley has performed thousands of RCP one-on-one consultations, helping people feel better by getting to the root cause of their symptoms.  In this episode, Morley talks about becoming obsessed with copper in the mitochondria. He dives into what you need to know about the mitochondria and how to ensure you're getting excellent mitochondria function. Then, Morley digs deep into copper; he explains precisely why you need more copper in your diet, and the reason copper is critical for anyone following a ketogenic lifestyle. Tune in as we chat about the problem with ascorbic acid and which three things will improve your copper levels.  Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphaste.  https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products.  Bioptimizers Masszymes for better digestion on keto and carnivore. Get your FREE bottle of Masszymes right now by heading to http://www.masszymes.com/ketofree and use coupon code ketokamp10 .  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [01:00] How Morley Became Obsessed with Copper in the Mitochondria Morley was born into a very sickly family with many illnesses.  After doing medical research, Morley found that in the world of science, they separated copper from iron metabolism.  In traditional Chinese medicine, copper is the general, and iron is the foot soldier. When the general is not around, foot soldiers go crazy. This is exactly what happens inside our bodies.  [06:10] What You Need To Know About Mitochondria In The Human Body We've been trained to think of the mitochondria as an energy furnace. People think that the mitochondria just put out energy.  There are 40 quadrillion mitochondria in our body. The average cell has about 500 mitochondria. The average liver cell has 2,000, kidney cells have 4,000, heart cells have 10,000, and a mature egg in a woman's body has 600,000 mitochondria.  The cells that are primarily relied upon for survival have the most mitochondria.  Morley likes to say, “ignore the enemies; ignite the energy.”  Morley has learned that if you don't have copper in your diet and don't have retinol to make copper bioavailable, you're not getting excellent mitochondria function. If mitochondria cannot produce energy, they cannot recycle iron.  [21:30] Ferritin In The Body and The Reason You Need Copper To Stay Healthy  There are four different forms of ferritin in the body.  There are two principal flavors: heavy chain and light chain. Whenever you see the phrase heavy chain, it means copper is involved.  The light chain is expressed most extensively in the liver. The heavy chain is expressed chiefly in the heart.  There is also serum ferritin. Many people believe that ferritin in the blood accurately reflects what's happening inside cells. However, when you get serum ferritin high, you toxify the liver.   When you suppress copper in an animal's diet, iron will rip up in the liver. [32:20] We Need To Make 2.5 Million Red Blood Cells Every Single Second  70% of the iron in the body is in hemoglobin. There's a recycling system for iron called the reticular endothelial system.  Every second of every day, we need to make 2.5 million red blood cells. In 24 hours, we make 2 trillion red blood cells. It only takes 24 milligrams of iron to support that level of production.  [39:50] The Reason You Need More Cooper on A Ketogenic Diet  if you ferment sugar without oxygen, you get two units of energy.  If you oxidize the sugar, you're going to get around 34. If you oxidize fat, you'll get 140 units of energy.  90% of the energy comes out of the mitochondria. It does not take a lot of copper to run our body; copper creates energy.  If you're going to have a keto diet, you better have a healthy supply of copper. The metabolism of fats is copper-dependent.  You cannot digest copper in your diet if you don't have fat in your diet.  [48:10] Ascorbic Acid Is Destroying The Bioavailability of Copper  Ascorbic acid is not the whole food vitamin C complex. Ascorbic acid is a prooxidant, whereas vitamin C molecule complex is an antioxidant.  Ascorbic acid blocks the absorption of copper.  You need to know that ascorbic acid, vitamin D, and zinc destroy the bioavailability of copper.  When you destroy the bioavailability of copper, iron rises in the tissue.  [57:40] How You Can Get More Copper Into Your Body Through Diet  We need to lower the iron footprint in our bodies and increase the copper footprint. You need a mineral base in your water and in your foods.  Also, eat more real food that is organically grown. Plus, more fat will be essential.  Get more cooper from bee pollen, real vitamin C, and grass-fed beef liver.  There is much more beta carotene in the grass than in oranges and carrots.  Also, to deal with stress, you need to have more magnesium in your diet. AND MUCH MORE! Resources from this episode:  Check out The Root Cause Protocol: https://therootcauseprotocol.com Follow The Root Cause Protocol Instagram: https://www.instagram.com/therootcauseprotocol/ Facebook: https://www.facebook.com/RootCauseProtocol Magnesium Advocacy Group - discussing the Root Cause Protocol: https://www.facebook.com/groups/388392151228860 Cu-RE Your Fatigue: The Root Cause and How To Fix It On Your Own: https://www.amazon.com/gp/product/1662910282/benazadi-20 Request A Test: https://requestatest.com Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphaste.  https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products.  Bioptimizers Masszymes for better digestion on keto and carnivore. Get your FREE bottle of Masszymes right now by heading to http://www.masszymes.com/ketofree and use coupon code ketokamp10 .  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

In some health and fitness circles, where ascorbic acid is considered a "synthetic form of vitamin C," influencers and some nutritionists warn their followers of the dangers of ascorbic acid. But is it really as bad as they claim, or like many things in nutrition, are they misinformed? I'll try to set the record straight, covering many of the reasons some people warn against using ascorbic acid, and also covering its benefits and why I use and recommend it. If you have thoughts or questions I don't cover, share them in the comments area. What is Ascorbic Acid? You may have heard the term "ascorbic acid," but what exactly is it? Ascorbic acid is a water-soluble vitamin, commonly known as vitamin C. Chemically speaking, it is an organic compound with the molecular formula C₆H₈O₆. This essential nutrient plays a crucial role in the functioning of our bodies. It acts as an antioxidant, protecting cells from harmful free radicals, which are unstable molecules that can cause damage. Ascorbic acid also plays a vital role in collagen synthesis, a protein that supports the structure and health of our skin, bones, and connective tissues. One study published in the Journal of the American College of Nutrition found that adequate vitamin C intake is associated with a reduced risk of chronic diseases, such as cardiovascular disease and certain types of cancer.Johnston, C. S., et al. (2014). Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: A randomized controlled trial. Journal of the American College of Nutrition, 33(5), 417-424. Another study published in Nutrients emphasized the role of ascorbic acid in enhancing immune function and supporting the body's defense against pathogens.Carr, A. C., et al. (2017). Vitamin C and immune function. Nutrients, 9(11), 1211. What is the difference between ascorbic acid and vitamin C? The terms "ascorbic acid" and "vitamin C" are often used interchangeably, but they're not the same. All ascorbic acid is vitamin C, but not all vitamin C is ascorbic acid. Ascorbic acid is a specific form of vitamin C. Chemically, ascorbic acid is the purest form of vitamin C, with the molecular formula C₆H₈O₆ I mentioned above. It is the active and most well-known component of vitamin C. However, vitamin C is a broader term that encompasses not only ascorbic acid but also other related compounds with vitamin C activity. These compounds include dehydroascorbic acid, ascorbyl palmitate, and various mineral ascorbates, which are salts of ascorbic acid. While ascorbic acid is the most common and readily available form of vitamin C, "vitamin C" describes the presence and activity of all the compounds. They contribute to the overall vitamin C activity and have similar functions and benefits as ascorbic acid itself. Different forms of vitamin C can be found in a variety of food sources. For example: Ascorbic Acid: This is the purest form of vitamin C and is commonly found in fruits and vegetables such as citrus fruits (oranges, lemons), berries (strawberries, blueberries), kiwi, bell peppers, and leafy greens (spinach, kale).USDA FoodData Central Dehydroascorbic Acid: This is an oxidized form of vitamin C that can be converted back to ascorbic acid within the body. Foods like broccoli, Brussels sprouts, and cauliflower contain dehydroascorbic acid, which can be utilized by the body to provide vitamin C activity. Ascorbyl Palmitate: This is a fat-soluble form of vitamin C that can be found in some processed foods, supplements, and skincare products. It is commonly used as a vitamin C supplement due to its stability and potential benefits in certain formulations.Yamamoto, Y., et al. (2001). Stability of ascorbyl palmitate in solid lipid nanoparticles. Journal of Agricultural and Food Chemistry, 49(3), 1456-1460. Mineral Ascorbates: These are mineral salts of ascorbic acid,

Are there any natural cancer cures out there? What the heck is the abscopal effect? Should you pursue it? What is the goal of your treatment? How do you decide between treatment A versus treatment B? Are antioxidants always a good idea? Join us in this jam-packed episode where we discuss details on these topics and much, much more. In this episode, Tina & Leah discuss concepts behind some natural agents used in cancer care.  Retractions of Dr. Bharat Aggarwal's papers on Curcumin/BoswelliaHigh dose, intravenous vitamin C may improve outcomes for those with pancreatic cancer receiving radiotherapyExample of a clinic in Germany that does whole-body therapies, including hyperthermia Antioxidants may encourage cancer cell survival, undermining treatments that kill cells via oxidation (example: radiation)  High doses of some natural compounds (ex: curcumin) complement treatment through oxidation, not as antioxidants Possible interaction of curcumin with tamoxifen/endoxifenTamoxifen as a prodrug, and the interactions that may occurPrevious episodes for more details on topics mentioned in this episode:Supplements 101: Curcumin, Episode #40The Truth about those Antioxidants, Episode #33Dose translation from animals to humansCurcumin can lead to cells protecting themselves through Nrf2 activationSupport the showFind our podcast useful? Please share it! Review & rate us ! (every bit helps!)Email us: thecancerpod@gmail.comWe are @TheCancerPod Instagram Twitter Facebook Want to support us? Donate through Buymeacoffee (Which is perfectly fine in moderation!)

Episode SummaryDavid Block is the Founder and CEO of Previnex, a nutritional supplement company that is committed to using science, clinically-tested ingredients and going above and beyond the testing and production standards required in the industry. Today, Whitney and David talk about the nutritional supplement industry, what ingredients to look for and to avoid when purchasing vitamins and supplements, and where you can get the highest quality products. David speaks to the distribution channel in the vitamin supplement space, his passion for optimal health and wellness, and what inspired him to launch Previnex. Episode SponsorRunner Click Pro – https://pro.runnerclick.com/ (https://pro.runnerclick.com/) Key Takeaways01:02 – Whitney Heins introduces today's guest, David Block, who speaks to his background in endurance athletics and how he became an expert in all things nutritional supplements 13:02 – The Previnex origin story 17:09 – Why there are loose regulations in the supplements industry 25:16 – Best practices on what ingredients to look for when shopping for nutritional supplements 32:26 – Finding other high-quality products (outside of Prenivex) 40:28 – Should you buy supplements through Amazon? 43:48 – David provides his thoughts on gummy vitamins 47:31 – Whitney thanks David for joining the show and lets listeners know where they can learn more about Previnex Tweetable Quotes“I just became an expert in all things nutritional supplements. And I was just bothered by a lot of what I saw which got me kinda crazy enough to start a company in the space.” (09:55) (David) “When you dive deep into the industry, unfortunately, you realize pretty quickly that it's a very predatory industry. Unless a consumer has a background in nutritional science, they honestly have a zero percent chance of understanding what ingredients can benefit them, or what products can benefit them, because it's super nuanced.” (11:31) (David) “The vision was never, ‘Let's be everything to everyone.' The vision was more, ‘Let's go into categories where we know we can make the best joint supplement, or immune supplement, or whatever it is, and have the clinical data to back it up.'” (16:04) (David) “If they get to X million dollars in sales, they'll just pay that two, three, four million dollar fine. And that's just a business decision. I could tell you so many stories, which I'm a little hesitant to do because I don't want to rip other companies, but this is actually like a business strategy in the industry. They go back to the predatory line of company profits and revenue matter more than consumer health, which is nuts. You can build a nice business by serving your customers really well with products of excellence.” (18:33) (David) “Vitamin C is a good tell for me. Ascorbic acid is like the lower quality, least expensive form of Vitamin C. It can be harsher on your stomach. So mineral ascorbates have always been my preferred form of Vitamin C. It's five to six times more expensive per kilo at the raw material level, but it's less harsh on the stomach. The data shows your cells readily intake mineral ascorbates and get more out of it than just ascorbic acid.” (29:20) (David) “I'll also look at the ‘other ingredients' for protein or meal replacement powders, because that's where a lot gets hidden. I don't want to see any gums because you can do it without gums. I don't want to see any sugar alcohols because those spike a glycemic response in insulin production, which you do not want over time. I don't want to see artificial anything. I don't want to see artificial sweeteners. It's just a tell-tale sign that a company is not doing it well. And so gums, sugar alcohols, preservatives, artificial anything would be things where I would say to avoid those products.” (31:46) (David) “Children's gummies drive me nuts, because I think they just have too much sugar or they don't have enough [vitamin minerals] because it would taste so bad...

Show Topic: Today I answered a TON of questions from Instagram. I don't have all the answers just like researching. I covered cod liver oil, Vitamin C vs Ascorbic acid, book recommendations, gray hair, healing/preventing cancer, red light bulbs, methylene blue and a ton more! Show Page: http://www.extremehealthradio.com/739 Mitolife Supplements: Coupon Code EHR15 http://www.extremehealthradio.com/mitolife LifeBlud Supplements: Coupon Code EHR10 http://www.extremehealthradio.com/lifeblud Visit Our Store: http://www.biochargeme.com Shop on Amazon: http://www.extremehealthradio.com/amazon Patreon: http://www.extremehealthradio.com/patreon Instagram: http://www.extremehealthradio.com/instagram Newsletter: http://www.extremehealthradio.com/subscribe Our Online Academy: https://www.extremehealthacademy.com Use code EHR14 for a free 2 week trial. Paypal: https://www.paypal.me/extremehealthradio

Vitamin C: so simple, so necessary... but what is it used for exactly? And what does deficiency look like? Is vitamin C deficiency linked to cancer incidence? Recurrence? Are there times when it should not be taken? Tina & Leah answer all of these questions and more!Vitamin C is vital to the production of collagen, immune cells, and energy from fats in our diet, to name just a few of its actions. Sometimes called ascorbic acid or ascorbate, vitamin C is a nutrient that you can get from various fruits and veggies. In this episode, we talk about scurvy, high school science experiments, and how vitamin C is both an antioxidant and the opposite of this, a pro-oxidant. We also cover the role of vitamin C before, during, and after cancer diagnosis. So, can you take vitamin C if you are getting chemotherapy or radiation? Tina & Leah tackle the topic head-on with a discussion of when this nutrient is proven to be detrimental, when it is safe and when some caution is needed (i.e., "talk to your doctor!").Support the show

Today, I am blessed to have here with me Morley Robbins. He is the creator and founder of The Root Cause Protocol and the Magnesium Advocacy Group. Morley received his BA in Biology from Denison University in Ohio and holds an MBA from George Washington University in healthcare administration. Morley has trained in wellness coaching, nutritional counseling, and functional diagnostic nutrition. He is also known as the Magnesium Man due to his extensive research into and understanding of magnesium's role in the body. Morley's research saw him deciphering the intricate relationship between magnesium, iron, copper, and calcium as a way to free ourselves from illness and dis-ease. As a certified health coach with expertise in Hair Tissue Mineral Analysis (HTMA), Morley has performed thousands of RCP one-on-one consultations, helping people feel better by getting to the root cause of their symptoms.  In this episode, Morley talks about becoming obsessed with copper in the mitochondria. He dives into what you need to know about the mitochondria and how to ensure you're getting excellent mitochondria function. Then, Morley digs deep into copper; he explains precisely why you need more copper in your diet, and the reason copper is critical for anyone following a ketogenic lifestyle. Tune in as we chat about the problem with ascorbic acid and which three things will improve your copper levels.  Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [01:00] How Morley Became Obsessed with Copper in the Mitochondria Morley was born into a very sickly family with many illnesses.  After doing medical research, Morley found that in the world of science, they separated copper from iron metabolism.  In traditional Chinese medicine, copper is the general, and iron is the foot soldier. When the general is not around, foot soldiers go crazy. This is exactly what happens inside our bodies.  [06:10] What You Need To Know About Mitochondria In The Human Body We've been trained to think of the mitochondria as an energy furnace. People think that the mitochondria just put out energy.  There are 40 quadrillion mitochondria in our body. The average cell has about 500 mitochondria. The average liver cell has 2,000, kidney cells have 4,000, heart cells have 10,000, and a mature egg in a woman's body has 600,000 mitochondria.  The cells that are primarily relied upon for survival have the most mitochondria.  Morley likes to say, “ignore the enemies; ignite the energy.”  Morley has learned that if you don't have copper in your diet and don't have retinol to make copper bioavailable, you're not getting excellent mitochondria function. If mitochondria cannot produce energy, they cannot recycle iron.  [21:30] Ferritin In The Body and The Reason You Need Copper To Stay Healthy  There are four different forms of ferritin in the body.  There are two principal flavors: heavy chain and light chain. Whenever you see the phrase heavy chain, it means copper is involved.  The light chain is expressed most extensively in the liver. The heavy chain is expressed chiefly in the heart.  There is also serum ferritin. Many people believe that ferritin in the blood accurately reflects what's happening inside cells. However, when you get serum ferritin high, you toxify the liver.   When you suppress copper in an animal's diet, iron will rip up in the liver. [32:20] We Need To Make 2.5 Million Red Blood Cells Every Single Second  70% of the iron in the body is in hemoglobin. There's a recycling system for iron called the reticular endothelial system.  Every second of every day, we need to make 2.5 million red blood cells. In 24 hours, we make 2 trillion red blood cells. It only takes 24 milligrams of iron to support that level of production.  [39:50] The Reason You Need More Cooper on A Ketogenic Diet  if you ferment sugar without oxygen, you get two units of energy.  If you oxidize the sugar, you're going to get around 34. If you oxidize fat, you'll get 140 units of energy.  90% of the energy comes out of the mitochondria. It does not take a lot of copper to run our body; copper creates energy.  If you're going to have a keto diet, you better have a healthy supply of copper. The metabolism of fats is copper-dependent.  You cannot digest copper in your diet if you don't have fat in your diet.  [48:10] Ascorbic Acid Is Destroying The Bioavailability of Copper  Ascorbic acid is not the whole food vitamin C complex. Ascorbic acid is a prooxidant, whereas vitamin C molecule complex is an antioxidant.  Ascorbic acid blocks the absorption of copper.  You need to know that ascorbic acid, vitamin D, and zinc destroy the bioavailability of copper.  When you destroy the bioavailability of copper, iron rises in the tissue.  [57:40] How You Can Get More Copper Into Your Body Through Diet  We need to lower the iron footprint in our bodies and increase the copper footprint. You need a mineral base in your water and in your foods.  Also, eat more real food that is organically grown. Plus, more fat will be essential.  Get more cooper from bee pollen, real vitamin C, and grass-fed beef liver.  There is much more beta carotene in the grass than in oranges and carrots.  Also, to deal with stress, you need to have more magnesium in your diet. AND MUCH MORE!   Resources from this episode:  Check out The Root Cause Protocol: https://therootcauseprotocol.com Follow The Root Cause Protocol Instagram: https://www.instagram.com/therootcauseprotocol/ Facebook: https://www.facebook.com/RootCauseProtocol Magnesium Advocacy Group - discussing the Root Cause Protocol: https://www.facebook.com/groups/388392151228860 Cu-RE Your Fatigue: The Root Cause and How To Fix It On Your Own: https://www.amazon.com/gp/product/1662910282/benazadi-20 Request A Test: https://requestatest.com Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Free 7 Day Keto Challenge May 9th 2022. Register your free spot here: https://kka.mykajabi.com/keto-challenge Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

In today's episode I talk all about Vitamin C vs Ascorbic acid. How 90% of the Vitamin C supplements on the market are a synthetic form that is harmful to our health and sourced from GMO corn in China. I also share the history of how this supplement became a staple in most households, the importance of whole food vitamin C and where to find it.Join my membership site The GB Collective for $9.99/month here. (Exclusive listener pricing!)Acerola cherry powder@gabby.borgerink@the.gbcollectivehello@gabbyborgerink.com

03:05  History of Aluminum Sulfate use in Water Treatment11:24  As a phosphate remover14:09  Alum vs Ascorbic acid for stain removal24:27  Green 2 Clean 35:43  Killing Black Algae with Alum36:22  Alum/CyA removal method (lowering the Cyanuric acid chemically)Jump right in. The water's fine. Join us, Poolside!Find us onWebsite: https://talkingpools.com/Instagram: https://www.instagram.com/talkingpools/Facebook: https://www.facebook.com/TalkingPools Twitter: https://twitter.com/TalkingPoolsYouTube: Talking Pools Podcast - YouTubeOnline Pool Education Classes: https://poolclass.teachable.com/Rudy's Books:  Rudy Stankowitz - Author POOL MAGAZINE Pool Magazine is leading up to the minute news source for Swimming Pool News and Pool Features. OuHow to Get Rid of Swimming Pool Algae Ha The most comprehensive guide on algae prevention and remediation you will ever own. Aquatic Facility Training & Consultants Online CPO & AFO Certification Classes

WELCOME EVERYONE! IT'S THE EAZYSENSE SHOW!. WITH HOST-DR. BRODERICK- COMING TO YOU LIVE FROM BOLD BRAVE MEDIA & TUNE IN RADIO My Showpiece Wednesday Evening, May 12th, 2021 at 7PM Eastern-The Covid Brain, THE EAZYSENSE SHOW-#78 Preferred Health Magazine, editor-in- chief Angelina Rios speaks of Dr. Broderick's work on the Covid Brain LIVE during the Melissa Billy Clark Show!!! Tau publication --mine-in Medcrave published August 22, 2021- Jahnavi had it offline for me to correct typesetter- this is how my book will be done cannot believe my CPA-She stopped my taxes from being done-suspended them with a thousand dollar retainer-and my work is disrupted. I had a wonderful Mother's Day and I hope you did too.We're going to film on Bold brave TV.com.Tom is beefing up the ad at the end of the show. I am back to my book coming from singapore as soon as grades are done.Serena and Nada will help. .I want this done by June 30th and that is when the Med research Archives publication will be done.Oh the provost, I have a list of publications and Jasmine will help, Topics:Variant 1.617 is at the crux of the Indian Covid Crisis! Nature, May 11th, 2021. Photo of indian people holding their oxygen tanks as they line up to fill Oxygen tanks. I have a nitrogen tank in my lab and I cannot believe this sight. You see we use nitrogen to remove the oxygen from the cell in which we wish to see neurotransmitters, Ascorbic acid removes oxygen from the brain , the part that is making neurotransmitters in free radicals. So critical to see the different roles of the same molecule in different parts of the body, brain and blood. Prime Minister Modi is under severe criticism for not locking down. He gathered billions of people to celebrate the immunity of the Inisian . Look now! My work involves India , the prime minister, the Indian Government and Indian Angel. 4 billion people in a space one third the size of the US. RAising of taxes and the blunder of thinking he had cured covid. Eazysense is worried about its contracts, Does anyone know about word press- yes Tom knows a way to program a website- I have hundreds to thousands of notes for me to approve on this, This is what I am hearing,.Oh, a disaster: the huntingtin gene, the hope of cure for Huntington's disease is not working. The gene theory here has failed. Billions of dollars lost. Billions of hearts broken,. Dr. Farley in New Jersey says only 5 % of the gene theories for worrying about our genes are actually the worry. Covid long haulers- the symptoms mimic chronic fatigue syndrome-Paul- Let us look into meds for chronic fatigue syndrome. I think Covid is a prion inside and out!!! and I think that some vaccines could cure PD- Patent protection gone US for and Germany against. The Annals of Medicine- the New Yorker- can we regenerate a liver? Yes, the area around the penumbra in stroke victims does this. My work shows regeneration. the BRODERICK PROBE regenerates the transfer of electrons, https://www.preferredhealthmagazine.com/Dr. Patricia A. Broderick, Medical CUNY School of Medicine, CCNYProfessor broderick@med.cuny.eduWebsites: https://www.ccny.cuny.edu/profiles/patricia-broderickhttps://www.eazysensenanotechnology.comhttps://www.eazysensationalbrainimaging.comhttps://www.eazysense.com

Ascorbic acid or vitamin C is a known antioxidant. Clinicians have conducted numerous studies to discover its role and effectiveness on life-threatening diseases such as sepsis, acute respiratory distress syndrome (ARDS), cancer and COVID-19. Dr Alpha 'Berry' Fowler joins us in this episode to share his work on vitamin C and its role in improving the survival of critically ill patients. He also talks about ongoing trials on vitamin C and its possible benefits on COVID patients. If you want to know more about the research backing up the success of vitamin C in disease treatment, then this episode is for you.   Here are three reasons why you should listen to the full episode: Learn the mechanism of sepsis in lung disease. Discover the role of vitamin C in treating patients with sepsis and ARDS. Find out more about past and ongoing trials on vitamin C.   Resources Learn about Dr Fowler's Phase 1 safety trial of IV vitamin C in patients with severe sepsis. Explanation lecture of the CITRIS-ALI study by Dr Fowler JAMA publication on CITRIS-ALI Article on the sequential organ failure assessment (SOFA) scores and mortality of patients involved in the CITRIS-ALI trials Dr Paul Marik's protocol for sepsis using vitamin C and steroids   Episode Highlights [04:02] How Dr Fowler's Research on Bacterial Sepsis Began Dr Fowler started working on mouse models to investigate sepsis. A solution made from mouse pellets was injected into ten mice, five of which received a treatment of vitamin C. The septic mice in the control group all died while those treated with vitamin C were crawling around, drinking water and eating. Dr Fowler then started using animal models to determine how vitamin C treats sepsis. [09:05] How Sepsis Damages the Lungs In sepsis, the lung barrier is injured. The progression of sepsis traps activated neutrophils in the capillary space of the lungs. Activated neutrophils release their DNA and enzymes, damaging the capillaries. Plasma then fills the air spaces, causing the patient to drown in their fluid. [09:34] The Role of Vitamin C in a Septic Lung In vitamin C-treated mice, the lung’s barrier function is preserved. Vitamin C stops neutrophils from disgorging their DNA into the extracellular space. Free DNA has become a marker to predict mortality. Blood reanalysis showed vitamin C lowered free DNA circulation as a result. Vitamin C completely inhibits the expression and appearance of inflammatory proteins. [16:15] Phase 1 Safety Trial Outcomes In a randomised, blinded trial, 24 patients were enrolled to determine the safety of vitamin C. Organ failure score was tracked in all patients. The higher the score, the higher the incidence of mortality. Patients treated with vitamin C saw a dramatic and significant reduction in their organ failure score. Vitamin C also improved their chance of survival. Intermittent infusion of vitamin C every 6 hours could get the plasma level up to 3000 times the normal level. [25:47] Phase 2 Proof-of-Concept Trial Outcomes Patients enrolled in the study had septic ARDS. The vitamin C treatment resulted in no adverse event. After 96 hours, 19 of 83 placebo patients died while only 4 of 84 patients with vitamin C died. Upon follow-up after 28 days, 46% of placebo patients died while only 30% of treatment patients died. This was the first blinded trial to show vitamin C’s impact on the mortality of patients with ARDS. [28:17] Explaining the Inconsistency of the SOFA Score Jean-Louis Vincent created the SOFA score. Jean-Louis Vincent sent a letter to the editors of Dr Fowler's work that the data was incorrectly analysed. Reanalysis showed the patients who died had the top SOFA score. Vitamin C significantly impacted organ failure scores. Vitamin C treatment resulted in a significant number of ICU-free days, improved mortality and more hospital-free days at day 60. [36:05] Is There Another Trial Underway? The NIH tasked the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network to turn towards COVID treatment.  Dr Fowler started a trial on vitamin C as a treatment for patients with early COVID pneumonia, and the results are dramatic. There is another trial for sepsis and vitamin C planned by the PETAL Network involving 1000 patients across 69 medical centres. [39:48] Why Larger Doses of Vitamin C Are Not Administered The primary concern for higher doses of vitamin C is the formation of renal stones. A safety trial is first recommended before vitamin C treatment for COVID pneumonia can begin.    7 Powerful Quotes from This Episode ‘The cage that the mice got the sepsis and the vitamin C, they were all crawling around, drinking water and eating. And I knew at that point that we had stumbled on something pretty significant’. ‘One of the first things we found was that the lungs of the treated mice that were septic, they weren’t injured’. ‘Most people understand sepsis as being a bacterial infection, but they don't understand that it's actually taking all the organs and causing oxidative damage to multiple organs, not just the lungs’. ‘We had kind of a basic grasp on the immune system and how vitamin C could alter the septic immune response and how vitamin C could protect the lung’. ‘Vitamin C was actually improving the possibility of survival’. ‘The amount of vitamin C that you administer is critical. Dose matters’. ‘You’re going to save not only thousands and eventually more — hundreds and thousands of lives. You’re going to reduce hospital bills enormously’.   About Dr Fowler In his 35 years of service at VCU, Alpha A. ‘Berry’ Fowler, M.D., Professor of Medicine and Director, VCU Johnson Center for Critical Care and Pulmonary Research, has had a profound influence at VCU and beyond. Considering his robust grant support and over 300 publications and abstracts in clinical areas including adult respiratory distress syndrome (ARDS) and sepsis, he might well be lauded for that alone.  Likewise, with over 16 years as Pulmonary Disease and Critical Care Medicine (PDCCM) Division Chair, with numerous ‘Top Doc’ awards and other honours, his pursuit of excellence in clinical care, impacting thousands of patients and their families, might well be the highlight of most careers.  To learn more about Dr Fowler’s research on vitamin C, you may contact him at 804-828-9071 or send a message to alpha.fowler@vcuhealth.org.    Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your friends so that they can learn more about vitamin C. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. If you would like to work with Lisa one to one on anything from your mindset, to head injuries,  to biohacking your health, to optimal performance or executive coaching, please book a consultation with Lisa here: https://shop.lisatamati.com/collections/consultations Lisa's latest book Relentless chronicles the inspiring journey about how a mother and daughter defied the odds after an aneurysm left Lisa’s mum Isobel with massive brain damage at age 74 and the medical professionals told her there was absolutely no hope of any quality of life again. Lisa used every mindset tool, years of research and incredible tenacity to prove them wrong and to bring her mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/ For Lisa’s other two best-selling books Running Hot and Running to Extremes chronicling her ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Go to www.runninghotcoaching.com for Lisa and Neil’s online run training coaching. For their epigenetics health program all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. For Lisa’s gorgeous and inspiring sports jewellery collection ‘Fierce’, go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. To pushing the limits, Lisa   Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Hi everyone and welcome to Pushing the Limits. This week I have an exciting interview with intensive care medicine doctor, Dr Berry Fowler, who is an intensivist from the Virginia Commonwealth University. The director of the VCU unit via 35 years of service at the VCU Johnson Center for Critical Care and Pulmonary Research. And he's also the author of a number of studies around vitamin C. So today we're continuing that conversation that we've been having in the last few weeks around the importance of vitamin C. Last week, we had Professor Margreet Vissers on, from Otago University, talking about—who worked with vitamin C in cancer. She's been studying this for 20 years. And Dr Berry Fowler has been studying vitamin C in regards to sepsis and pneumonia and how to use it in COVID. And he's been researching in this area with vitamin C for over 15 years. So some really amazing insights into this incredible vitamin and how it can help with all of these things. So please don't miss this episode. If you enjoy the content, please share it with your family and friends. You know, there’s some important messages that we're wanting to get out in this vitamin C thing that I've been doing, because I lost my father recently and this would have been a major player and I was desperate to get him help with intravenous vitamin C, and I was unable to until way too late. And so I'm desperately wanting to get out the information about this research about the clinical studies that have been done, the research that's been done, to share this really important information.  As always, I really appreciate a rating or review for the show. If you can do that, that'd be so so appreciated. And if you've got any questions, please email me at support@lisa tamati.com, if you want to discuss anything that was brought up in these topics, in this podcast. I'm also doing some one on one consultations. I have a limited number of spaces available for people who are wanting to work with me one on one. If you are facing difficulties in areas from whether it be around some of your health aspects like head injuries, obviously I've spent five years researching head injuries. I have a lot of knowledge around vitamin C. I have a lot of knowledge around biohacking, around epigenetics trained as an epigenetics coach, gene testing, and so on. And I work with a very small number of people who are needing help with these areas. As well as of course run coaching and mindset in high performance. So if you're wanting to get some one on one support with me, please reach out to me it's lisa@lisatamati.com. And I can send you the information there. Right over to the show now with Dr Barry fellow who is sitting in Virginia in the USA. Well welcome everybody to Pushing the Limits. This week. I have a very special interview continuing our series around intravenous vitamin C or vitamin C in general. I have Dr Barry Fowler with me, who is sitting in Virginia and Dr Fowler has agreed to come and have a little chat today about his work in this area. Dr Fowler, I've done a wonderful extra introduction. So we won't go into all your amazing credentials and your achievements, of which there have been many. But Dr Fowler, can you just give us a little bit of background? You are the director of the VCU Virginia University over in the States. Can you tell us a little bit about your work and your background? Dr Berry Fowler: Okay, well, I am professor of medicine in the Division of Pulmonary Disease and Critical Care Medicine and I'm one of the ancient doctors in the division, just turning 71 last week. I trained at the Medical College of Georgia in the US, then went to the Medical College of Virginia in the US, then went to the University of Colorado for pulmonary and critical care disease training, and then came back and joined the faculty at Virginia Commonwealth University which used to be the Medical College of Virginia, it's now VCU, in 1982 and I've been here ever since. Lisa: Wow. Dr Berry: I rose slowly through the ranks. I led the pulmonary division for a number of years, for approximately 17 years, and then stepped aside in 2016. And all during this time, at least for 13 years now, we've had this interest in vitamin C. And it's interesting how our interest in vitamin C developed. It first started at a very molecular level where we were studying cardiac ischemia, but some of the heart attendings. And then slowly began to get back to what we have been doing for years which was bacterial sepsis. And we had some molecular reasons that drove us towards vitamin C. And so first thing we did was we created an animal model of sepsis. And let me explain that. It was pretty straightforward to create. We had 30 gram mice and we went to the mouse cage and collected mouse pellets. Then took them to the laboratory and sonicated them really hard until it became a solution. Lisa:  So this is the fecal matter. Yes. Dr Berry: And we would take that solution and centrifuge it really hard so that all the solid matter went to the bottom of the tube and we just took off the liquid from the top, which contained multiple different kinds of organisms. Lisa:  So all the bacteria. Yes. Dr Berry: Yes. And so we took that, put it in the refrigerator overnight and then came in the next morning. And we had 10 mice. We had 5 control mice and then 5 treatment mice. So all the mice first were injected into their peritoneal space, you mentioned that earlier, with a tenth of an mL of this solution containing all this bacteria. And so all 10 mice. And then in the mice that were going to receive the vitamin C, we injected a tenth of an mL, which was 200 micrograms per gram of bodyweight of the mice and then closed off the light. By that point, it was about 4:00 in the afternoon. And just let the mice sit in the laboratory where we had left them and I always get to work at 6:00 in the morning and I was thinking, ‘Holy cow, I got to see what's going on.’ And so I went into the lab where we had the mice and the cage that was the control mice that were septic. They were all dead. In the cage that the mice got the sepsis and the vitamin C, they were all crawling around drinking water and eating. Lisa:  Wow. Dr Berry: And I knew at that point that we had stumbled on something pretty significant. This take us back to around 2010. Maybe 2009. My laboratory has had this intense interest in sepsis ever since I finished my training at the University of Colorado. And so what we decided is that we would begin to use the treatment animals and some control animals to determine exactly how vitamin C was working. Lisa:  To look at the molecular, the mechanism of action. Why is this happening? Why are they surviving better? Dr Berry: So what we did was—in these studies, we were always comparing the control mice to the treated mice. And one of the first things we found was that the lungs of the treated mice that were septic, they weren't injured. Lisa:  Wow. Dr Berry: And we have a number of ways to determine the way a lung is injured. One of the things that happens in sepsis, and this might have been what you and I were talking about earlier, is the lungs barrier function, which is the ability to keep the blood in the blood and keep the air in the air. Lisa:  Yes. Dr Berry: It gets injured. And so the bloodstream floods into the airspaces of the lung. Lisa: And fills it. Dr Berry: Yes. And one of the things we discovered was lung barrier function was preserved and the vitamin C treated septic mice. Lisa: Wow. So you're perceiving that it’s stopping the plasma and the neutrophils getting into the alveolar space. Dr Berry: Exactly.  Lisa: And the NET— of one of your lectures, you talk about neutrophil extracellular traps (NET). Is that a part of the barrier function?  Dr: Berry: Very nice. When are you starting medical school? Lisa: Thank you, Dr Fowler. Dr Berry: So what happens as sepsis progresses is that there are a bunch of molecules that live in the capillaries of the lung that begin to get expressed. And what they do is they trap neutrophils that are activated in the capillary space of the lung. And one of the things that happens in a highly activated neutrophil is they disgorge their DNA and all of the enzyme systems inside a neutrophil begin to damage the capillaries. And then what happens as the capillaries get injured, the plasma from the lung, just a vein from the bloodstream, just flows into the lungs. Lisa: So you’re basically lost—it's like your skin barrier, if you like, between the ear and your insides is disintegrating. Dr Berry: Well, one injury from sepsis is like drowning. Lisa: Wow, so you fill it with your own fluid. Dr Berry: The airspaces of the lung fill up with your own plasma. Lisa: So when you have, cause sepsis—I don't think most people are not aware of the progression of sepsis to acute respiratory distress syndrome. That this is a sort of a linear progression that happens, isn't it? That you actually get lung—because most people understand sepsis as being a bacterial infection but they don't understand that it's actually taking all the organs and causing oxidative damage to multiple organs, not just the lungs, but particularly the lungs. And so this is a very important finding that what you've had here because this means that if you can stop the vitamin C, if the vitamin C can stop the neutrophils from disgorging their own DNA into the extracellular space, which is then, that's in a marker, isn't it? That cell-free DNA, when you take a plasma drawn and you see that cell-free DNA floating around at a certain level, that's a predictor of mortality, isn't it? Dr Berry: Listen, you've done some fabulous reading. But let me just tell you, it's been known for several years that in septic individuals, one of the unfortunate things that will predict mortality is how high the cell-free DNA arises in the circulation. And I don't want to jump too far here, but I will tell you and the vitamin C trial that we reported one year ago this month, that when we reanalyzed the blood from those individuals, we found that vitamin C dramatically lowered the cell-free DNA in the treated patients. Lisa: Wow. That was in the CITRIS-ALI study? Dr Berry: Exactly. Lisa: Oh, okay. That's a new finding from that study because, yes, we will go through that progression of how you got to do that study. So let's bookmark that for a moment and backtrack because that is a very important finding for that study. So let’s backtrack a little bit. So we are talking about vitamin C being able to protect the lungs if we put it very simply and protect the barrier function of the lungs, stop the neutrophils from disgorging the DNA and causing these traps, which is a predictor of mortality. What are other things is vitamin C doing? And why is a septic patient, without fail, going to be very low in vitamin C? So you’re using that for Vitamin C. Dr Berry: I'll get to that in a minute. But what we demonstrated in a huge number of murine mouse studies is that the septic lung in a control animal, the septic lung began to express many inflammatory proteins. And that's just your endogenous immune system trying to protect itself. But we showed in the next cage, in the septic mice that we had treated with Vitamin C, that the expression and the appearance of those inflammatory proteins was totally inhibited completely.  Lisa: Wow. Dr Berry: Yes. The idea of leaping from preclinical animal studies into humans was that we had kind of a basic grasp on the immune system and how Vitamin C could alter the septic immune response and how Vitamin C could protect the lung. Well, protecting the lung in terms of septic critical illness is very, very important. Lisa: Absolutely. And so then you went to a phase one safety trial, which was really to look at some basic markers. Is this going to be damaging for people if they get vitamin C and look at hypertension? And is it going to affect the kidneys and so on. I think some of those safety mechanisms. Can you tell us a little bit about that phase one safety trial and then the outcomes of that trial? Dr Berry: Well, I can tell you, I had this really close colleague. His office sat right next to mine. He's a molecular biologist, basic scientist. And after we'd done all these murine studies, one day he walked in, he looked at me, said, ‘Fowler, this needs to go into the hospital. We've developed all this data. You've got to make it happen to get it into the hospital’. We designed this little safety trial, enrolled 24 patients. The safety trial was randomized and it was blinded. And so half the trial was just controlled sepsis. The other half was septic patients treated with Vitamin C and we had no idea who the hell was giving vitamin C to people who were critically ill. Lisa: Yes. Dr Berry: And we found it had no impact. But one of the things we were shocked at, and we were just trying to define, was vitamin C safe?  Lisa: Yes. Dr Berry: One of the things we tracked was what is called an Organ Failure Score. And we found that all of the patients treated with Vitamin C, their Organ Failure Score reduced dramatically and significantly. Lisa: Wow. Dr Berry: And the way Organ Failure Scores, basically you're counting numbers. A higher number is a higher incidence of mortality. Lower numbers are improved and that vitamin C was actually improving the possibility of survival. Lisa: So this is like, in my father's case, is the sepsis progressed and I was unable to get him Vitamin C as we discussed earlier, Dr Fowler, early enough for him to get to survive. But as I watched his sepsis progress, more and more organs started to fail. So his liver started to fail. His kidneys started to fail. His heart started to fail. And so this is the Organ Failure Score. If this person's Organ Failure Score is going up, that is a very strong predictor of mortality. Dr Berry: Yes. Lisa: Okay, so this was reduced with the people who received the Vitamin C in the small trial. Dr Berry: So what we did, we took the data, we combined it with our preclinical data, and applied to the National Heart Lung and Blood Institute. They had just published an announcement where they were asking for anybody who could think of some clever trial. And we said, ‘Well’. And so we submitted an application. What the NIH wanted, they wanted the proposal for a phase two, proof of concept trial. Lisa: Right. Dr Berry: And so what we proposed was a trial that had seven medical centers. I have friends in seven medical centers around the US. And with this application in and that was I guess you guys don't remember Hurricane Sandy. Lisa: Yes, I do. Dr Berry: Hurricane Sandy was just—it killed the Atlantic Coast of the US. And the National Heart Lung and Blood Institute happens to sit on the Atlantic Coast in Washington, D.C. And it was a year and a half before we found out that we had received the highest priority score because of the application that we had submitted. And the NIH gave us 3.2 million dollars to do a multicenter, randomized, double blind, placebo-controlled trial, proposing to administer 50 milligrams per kilogram of intravenous Vitamin C every six hours for ninety six hours. Patients were continuously receiving vitamin C. Lisa: Can you explain why that continuous topping up that level is important every six hours? Dr Berry: That's a great question. So from the safety trial that we had performed, we analyzed the plasma Vitamin C levels that we had achieved by infusing. So basically someone your size, for example, would probably get maybe 3 1/2 grams intravenously every six hours for ninety six hours. And what we showed was, we could get the plasma level up to basically three thousand times the normal plasma level. So from a normal diet, human plasma levels of vitamin C are about 70 to 80 micromolar. When you give the protocol that we had settled with, we got the Vitamin C levels up to five millimolar. Lisa: Wow. Dr Berry: Yes. And so that's what we were shooting for in this NIH trial. And that's what we did. We charged into it, the trial. What we had proposed again, was the Organ Failure Score as well as the two biomarkers. We also proposed in the secondary outcomes, days on mechanical ventilation. Lisa: Yes, which is hugely important. Dr Berry: And what we were studying specifically, was patients who were septic, who had gone on to develop acute lung injury called Acute Respiratory Distress Syndrome, ARDS. And so when a patient was septic, like your father, we would become a fly on the wall and visit the patient every day until a lung injury developed. And that's when they would get randomized. Lisa: This was a critical—from my analysis of the data, that was a critical thing in the phase. So you had to wait until I basically had developed ARDS before you were able to put them. So this wasn't really a sepsis trial, but more of an ARDS trial. So the progression of the sickness comes into play here, doesn't it? If you’ve gone through day one, like in the phase... Dr Berry: In the safety trial... Lisa: Yes. Dr Berry: The second aseptic individual walked in the door, that's when they got random. Lisa: Which is a much better, more effective with the timing. Dr Berry: We had a couple of patients who got Vitamin C in the emergency room. Lisa: Yes, wow.  Dr Berry: You know you have to get informed consent. You have to get the pharmacy on board and get the patient enthused. Lisa: I wish I'd had you tending to my father. We could have had that from the moment he got to the emergency. That would have been, I think we would have had a different outcome. But so this was a key point that you had to wait until I had developed ARDS. So in this CITRIS-ALI trial, so here you have, I think it was 47 patients in the control and 47 in the intervention group, was it right? Dr Berry: 83. And 84 in the Vitamin C treatment. Lisa: Oh, 83. I'm sorry. Sorry. So 167. One of the big questions I had in my— why was mortality not one of the primary objectives of the study? Dr Berry: That has been the most frequent question. When we answered the NIH, they had put out a program called, UM1, and we applied to the UM1 program and they were not interested in mortality as a primary outcome. Part of it was this. There had been hundreds of sepsis trials and nobody had ever shown any impact on a treatment for sepsis. And so NIH didn't want to get burned again so they said that they wanted a physiological outcome. That was the Organ Failure Score. And they wanted a biochemical outcome. Those were the biomarkers. Lisa: It's the C-reactive protein, procalcitonin and thrombomodulin. And yes. So the reasoning was that we don't want to shoot for the stars here and automatically hope for a decrease in mortality and a decrease of days in hospital. We're going to go for something else just to see if this has legs, so to speak, if this treatment is possible, possibly going to work. And that's why they went for the safer scores, rather than the mortality. Looking back, do you think... Dr Berry: By the way, we haven't talked about this yet, but SOFA stand for Sequential Organ Failure Assessment Score. Lisa: Thank you. Yes, it's amazing the jargon that you pick up and then forget that you haven't explained yourself. So what actually was the outcome? This was a seven multicenter trial. You did a double blinded. This was incredibly important because I know Dr Paul Marik had also done a study with intravenous Vitamin C, thiamine, and hydrocortisone. And one of the criticisms that was thrown at him was that it wasn’t a double blind, randomized controlled trial, so it didn't have any meaning, which is absolutely tragic. So this was—what was the outcomes of this phase two trial? Dr Berry: So we enrolled 170 patients. One of the placebo patients we had to take out because that patient did not have septic ARDS. They had Acute Eosinophilic Pneumonia. That's something else to discuss later. And then in the Vitamin C arm, we had two patients with Acute Leukemia who had no coagulation in their bloodstream and they were hemorrhaging into their lung and that was not sepsis. So as I mentioned, we had 83 in the control placebo and 84 in the vitamin C-treated group. First of all, we saw no, and I emphasize capital N-O, adverse events. There was not a single adverse event.  Lisa: Exactly. Dr Berry: All right. And so what we showed was in 96 hours, placebo patients in the trial, 19 of 83 died within 96 hours. Lisa: Wow. Dr Berry: In the Vitamin C group, 4 of 84 patients died. And if you look at the statistics and the analysis of that, the difference is P=0.0007. We then followed the patients out because in sepsis trials, there's always this demand to see what is happening to a patient at 28 days. Lisa: Yes. Dr Berry: And what we showed was 46% of placebo patients died and only 30% of the Vitamin C treated septic patients with ARDS died. Lisa: Wow, that's a huge result in my mind. Dr Berry: And that was the first trial. I'm not slapping myself on the back, but I will just tell you, that was the first trial to ever show in a blinded fashion, an impact on ARDS.  Lisa: Yes. On mortality of ARDS. Dr Berry: Yes. Lisa: And this was extremely sick people. Now, unfortunately, the SOFA scores didn't show any difference and the C-reactive protein markers didn't show any difference. Dr Berry: So let me explain. Lisa: Is it because... Yes, is it because of the mortality. Dr Berry: So we thought publishing the results of the trial in probably one of the most important journals on the planet, JAMA, which as it turns out, is a very, very conservative journal. And they had their ideas about what we could and we couldn't say. So we published, and this is very important for you to listen to and all of your listeners, we published that there was no difference in the SOFA scores at 96 hours. And immediately, letters to the editor started coming in and one of the most important letters to the editor was the person who created the SOFA score. His name is Jean-Louis Vincent in Brussels, Belgium. He told us that we had analyzed the data incorrectly and that what we were reporting was a survivorship bias. Lisa: What does that mean? Dr Berry: And what he said we needed to do, and he provided five publications where he had important statisticians tell him that analyzing the data, like we reported, as a worst rank, best rank scenario, that we had to reanalyze it so that the patients who died, what we were reporting was the SOFA scores on the people who had survived. Lisa: Not the ones who died. Dr Berry: We had not considered the SOFA score on the patients who died. Lisa: And because they died so quickly. Dr Berry: So what we did was we went back and the people who died along the way, those 19 patients, they got the top SOFA score. The patients who survived and left the unit, they got a low SOFA score. And so when we reanalyzed the data, according to the way these letters that had come in from Dr Vincent and two or three other colleagues, it turns out that Vitamin C significantly impacted the Organ Failure Score. Lisa: Wow.  Dr Berry: And then we—here's the important thing, we reported that February 25th of 2020. So you can go to JAMA, you can look it up and you can see our response to the SOFA score reanalysis. Lisa: Because this was a key factor in my father's case. They threw the CITRIS-ALI trial at me and the original data from JAMA, which said negative result, which when I analyzed... Dr Berry: That lets you know that the doctors were not reading JAMA. Lisa: Exactly. And they weren't on the up to date and they did not look at secondary outcomes and they did not look at the parameters of the score and I was not able to present the case. They had just read it briefly. Dr Berry: Let me go on. We had a strong trend to ventilator-free days and the people who got the Vitamin C, but it just missed statistical significance. Lisa: Yes. Dr Berry: But we had a strong significance for the people who got Vitamin C in Intensive Care Unit-free days. Lisa: Which is huge. Dr Berry: So the people who got Vitamin C had a significantly higher number of ICU-free days. There was an improved mortality. The other thing is patients who got Vitamin C had significantly more hospital-free days at day 60. Lisa: Wow. So they were actually out of the system altogether. Do you think—now this is controversial, I'm playing devil's advocate here. But do you think the fact that it costs so much for someone to be in ICU when they have sepsis—I think in America it's something like, to the order of 60,000 dollars US a day—and the medications that they are typically on are costing around 20,000 dollars a day, do you think that if you come along with Vitamin C and you start dropping the mortality rate, you start dropping the days? Is that part of the resistance to accept and acknowledge these findings, that the pharmaceutical companies are going to lose out on profit? Dr Berry: Oh no no no. No, no, no. At VCU, Virginia Commonwealth University—that Anitra knows well—the average care cost per day is about 46,000 per day because that accounts for medical care, nursing care, radiology, all laboratory data, respiratory care, caring for the ventilator. All of that is somewhere in the neighborhood of about 45 to 50,000 dollars per day. And so, if you have a treatment, first of all, that gets people out of the ICU earlier and keeps them out of the hospital, think about the impact on the cost of care. Lisa: Yes, it’d be huge. Dr Berry: But here's the other thing. There's not going to be any drug company out there who would argue with that. They are all trying to do the best they can with their different antibiotics, but the common antibiotics that are administered in an ICU when patients are septic levofloxacin, meropenem, vancomycin. Just one day of meropenem is 1500 per day. Lisa: Exactly. It's a lot of money.  Dr Berry: Yes.  Lisa: So you don't think that... Dr Berry: And listen to this. That's the cost of the drug. That's not the cost of pharmacy preparing the drug, cost of nursing administering the drug and so on and so on and so on.  Lisa: Okay, so all right. So if you can work this problem out and if you can get this in all ICUs around the world, we're going to save not only thousands and eventually more hundreds of thousands of lives, you're going to reduce the hospital bills enormously. So this is incredibly important work. And you've proven—so the statisticians proved in that phase two trial that the way that you are measuring it was incorrect because a lot of people, as you said, 19 died in those first four days in the control group and only four, so that skewed—if you like—the statistics to initially look like we hadn't had a win here. Now, that's been rescinded and you've managed to get JAMA to publish it in a different light, that the SOFA score was impacted. What has been the effect now? Have you got another trial underway or have you got one in sight? Because this work’s too important, obviously, not to be taken further into a phase three. Dr Berry: All right, so you are in New Zealand where there's not much COVID.  Lisa: No. Dr Berry: We are in the United States, where it's a pandemic, where we are close to 220,000 people who have died from the virus. We are at 50,000 new cases per day. Lisa: Oh my God. It's so...  Dr Berry: And there are somewhere in the neighborhood of 1,800 to 2,000 patients dying per day of COVID. And so because of that, the network that I'm part of, that unfortunately—I'm going to have to jump off and listen to it, because it's been going on since 2:00, the annual meeting of the Prevention and Early Treatment of Acute Lung Injury Network, abbreviated P-E-T-A-L, the PETAL Network. The PETAL Network was tasked by the NIH to turn sharply towards COVID treatments. Lisa: Yes. That makes sense. Dr Berry: And so we were thinking, ‘Well, maybe vitamin C to treat patients with early COVID pneumonia’. And so what we did was we started a trial. We have studied 20 patients now and that trial is complete, where patients who develop COVID infection and develop early COVID pneumonia, so it's just at the start of an oxygen requirement, are treated with Vitamin C and the results have been pretty dramatic. We are in the midst of writing that up. But again, it's a—open label trial. It's not blinded. Everybody in the world knows that an open label trial does not have the power like we did with CITRIS-ALI. Lisa: Yes. Dr Berry: And so what is happening at a world level is that all of the health organizations around the world have come to bear to try to design treatments for COVID pneumonia. Lisa: Yes. Dr Berry: And that is ongoing right now. And there are like 9 or 10 major networks in, across the world. Probably, I'm not sure if New Zealand is included in that, but Europe, the US, possibly Australia. I don't know if they commit to participating in what is called the network of networks formation. Lisa: Yes. Dr Berry: So right now, the next trial for patients with sepsis that's not COVID is going to be conducted by the PETAL Network where we will be probably next April, starting a trial with a thousand patients. Lisa: Wow.  Dr Berry: Using vitamin C conducted by the PETAL Network. Lisa: Gotcha. Dr Berry: And the PETAL Network has 69 medical centers. So doing a trial that would get a thousand patients can be done within a year. Lisa: Wow. So this is exciting stuff because this is hopefully you'll be able to reproduce and show a strong correlation between intravenous vitamin C and I'd like to see the decrease in the mortality rate. That would be a key factor. Some centers are already using vitamin C because as you mentioned before, there were no adverse reactions. And this is like in all of the studies that I've seen there has never— this is a low risk intervention and my argument when fighting for my father was that, ‘He's dying. There is no other options. Why can't I throw the bus in? Why can't I put intravenous Vitamin C’? And they were like, ‘You still have to go through all the ethics committees’. I had to sign off from every single doctor and every single nurse in the ICU unit of which there are many. Dr Berry: Well, let me make another statement. So Paul Marik, who was using 1.5 grams of Vitamin C, 200 milligrams of thiamine and 50 milligrams of hydrocortisone, administered every six hours. That meant that the patients were only getting 7 grams. Lisa: Very small amount. Dr Berry: In the CITRIS-ALI, I mean, some patients got 16 to 18 or 20 grams. Lisa: Yes. Dr Berry: According to body weights, 50 milligrams per kilogram. In the aftermath of that article that you mentioned that Marik published, there have been efforts to repeat that trial. The vitamins trial came out in January, using that and it failed. Then another trial, the ACTS trial using the Marik protocol failed. And then a trial that I just participated in called the VICTAS trial completely failed. And so the Marik protocol is not an effective treatment for sepsis. And well, look. As I think Anitra Carr mentioned to me a couple of years back, the amount of vitamin C that you administer is critical. Lisa: Absolutely. Dr Berry: So dose matters. And the adult, again, of your size, you probably weigh 120 pounds or something would probably get somewhere in the neighborhood of about 12 and a half to 13 grams, spread out over a 24-hour period. And then you would get it for four days. Lisa: Yes. And that is still a relatively low dose. Dr Berry: It is. Lisa: When I'm doing intravenous vitamin C with my mum, I did it with my dad prior and unfortunately, months prior to his aneurysm. Too little, too late. We were getting 30 grams. We get 30 grams a week. When I take my mum and niece today for an intravenous Vitamin C is a prophylactic as I try to keep her, as a 79 year old healthy, 30 grams. So why—I had this question certainly with Dr Marik’s protocol. It seemed to me to be very low, although the six hourly is obviously a very important point as well. Why not do the bigger dosages? Like in Japan, I know they did a study with up to a hundred grams of Vitamin C in a burns case, a burns trial, where they had some markers of sepsis there. Why are you not trying higher levels? Dr Berry: Let me come in here quick? Because I'm going to have to jump off in about 8 minutes. But listen to this. The major concern for those high doses of vitamin C, and if you talk to the oncologists who have been using it for years, they will give, like you said, they will give massive doses. And I'm talking massive, like in somebody with pancreatic cancer, they will get 60 to 80 grams intravenously, Monday, Wednesday and Friday for seven weeks. Lisa: Yes. Dr Berry: But the major concern, in somebody who's septic, who's hypotensive, in shock, that you're giving vitamin C, one of the major concerns is that it causes a significant rise in oxalate crystals formatiion in the kidneys. Now, I will mention here in the CITRIS trial, we had no evidence of renal stone formation. Lisa: No. And I mean, that was one of the arguments that the doctors had at me, ‘You could have damaged his kidneys’. And I said, ‘Well, the last time I looked, being dead damages your kidneys too’. To me, that wasn't even a consideration. And he had—after the very first vitamin C, and for my dad, his kidney function went from 27 percent to 33 percent. He's actually improved his kidney function overnight. And I know that's just one anecdotal case, but kidney stones are not going to kill you either. So surely that's not the most important consideration here when you've got a septic patient who is on death's doorstep. Dr Berry: With vitamin C struggling in the United States after the CITRIS trial, the Federal Food and Drug Administration, they always have to be concerned about adverse events. And we have put together a trial randomized and double blind using Vitamin C in patients with COVID-pneumonia. That's about to start. Lisa: Wonderful. Dr Berry: And we had, I unfortunately let my IND, Investigational New Drug lapse after CITRIS. And so I've had to claw our way back into the good graces of the FDA. And one of their major, major, major complaints was, ‘You're going to be forming renal stones’. And we're using the same protocol that we used in CITRIS. So FDA got their nephrologists involved and finally gave us the IND. But for us to begin treatment of COVID pneumonia, they have demanded that we first do a small safety trial to show that we are not causing any renal stone formation. We can get that done. We currently have somewhere in the neighborhood of 60 to 70 COVID patients in the MCV hospitals right now. Lisa: Wow. Well, Dr Fowler, look, I know I'd love to spend another five hours with you discussing all this because I think it's incredibly important, both for COVID and for the sepsis and for pneumonia and for obviously, for cancer. I just want to thank you for your dedication to this. I mean, you could be in retirement and sunning yourself somewhere, relaxing, but, you know... Dr Berry: That's right. Lisa: You know that this work is critically important. And I heard one of your lectures is the equivalent of two 747 planes going down every day filled with people. Dr Berry: Every day in the United States. Lisa: In the United States alone. Dr Berry: That’s just in the U.S. Lisa: Yes. And these people, thousands of families being destroyed with losing loved ones. I'm one of those, unfortunately, sitting here all the way in New Zealand. And so this work is incredibly important. So please keep going. And I'm desperate to hear what comes from this COVID clinical trials and the other sepsis trials, obviously. So thank you so much for your work, Dr Fowler, and I really appreciate you. Dr Berry: It's been wonderful meeting you and speaking with you, and your and your audience. And when you have Anitra on a couple of weeks, give her my regards. Lisa: I will definitely do that, Dr Fowler. That's been awesome. Thank you, Dr Fowler. And all the very best there in Virginia. Dr Berry: Take care. Bye. That’s it this week for Pushing the Limits. Be sure to rate, review and share with your friends, and head over and visit Lisa and her team at lisatamati.com.  

Another day, another IV vitamin C trial. It appears as if the dust is settling a bit on all this. This paper will be known as the ACTS trial for Ascorbic acid, Corticosteroids and Thiamine in Septic shock. Before digging into the paper, though, I provide a bit of a biologic rationale as why these trials should improve outcomes. Show notes: https://eddyjoemd.com/vitaminc/ Receive a FREE audiobook (TWO for Amazon Prime members) with your FREE 30-day trial by using my link for Audible: CLICK HERE! You will be reminded when your trial is ending, by the way.

Nesse episódio, João, Fred e Iago voltam com um quadro antigo do Podcast: Paciente pergunta! Dessa vez pra trazer as evidências em relação ao uso de vitaminas: Benefícios? Malefícios? Em quais pacientes vale mais a pena? Ouça tudo isso nesse episódio. Compartilha com a gente a sua experiência e dúvidas através do Instagram ou Twitter em @tadeclinicagem! Aproveita e assina a nossa newsletter! MINUTAGEM: [02:15] Experiências pessoais com multivitamínicos [07:20] Multivitamínicos em pessoas saudáveis [10:20] Vitaminas e COVID-19 [13:23] Vitamina C e resfriado [18:36] Vitaminas e efeitos adversos [31:06] Populações específicas [44:54] Salves [45:40] Resposta desafio anterior [46:33] Desafio da semana REFERÊNCIAS: 1. http://www.in.gov.br/materia/-/asset_publisher/Kujrw0TZC2Mb/content/id/34380639/do1-2018-07-27-instrucao-normativa-in-n-28-de-26-de-julho-de-2018-34380550 - Órgão: Ministério da Saúde/Agência Nacional de Vigilância Sanitária INSTRUÇÃO NORMATIVA - IN N° 28, DE 26 DE JULHO DE 2018 2. GUALLAR, Eliseo et al. Enough is enough: stop wasting money on vitamin and mineral supplements. Annals of internal medicine, v. 159, n. 12, p. 850-851, 2013. 3. MOYER, Virginia A. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: US Preventive Services Task Force recommendation statement. Annals of internal medicine, v. 160, n. 8, p. 558-564, 2014. 4. BJELAKOVIC, Goran et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane database of systematic reviews, n. 3, 2012. 5. HEMILÄ, Harri; CHALKER, Elizabeth. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews, n. 1, 2013. 6. THOMAS, Laura DK et al. Ascorbic acid supplements and kidney stone incidence among men: a prospective study. JAMA internal medicine, v. 173, n. 5, p. 386-388, 2013. 7. FESKANICH, Diane et al. Vitamin A intake and hip fractures among postmenopausal women. Jama, v. 287, n. 1, p. 47-54, 2002. 8. MILLER III, Edgar R. et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of internal medicine, v. 142, n. 1, p. 37-46, 2005. 9. OMENN, Gilbert S. et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England journal of medicine, v. 334, n. 18, p. 1150-1155, 1996. 10. Aarts, E. O., et al. "Prevalence of anemia and related deficiencies in the first year following laparoscopic gastric bypass for morbid obesity." Journal of obesity 2012 (2012). 11. Damms-Machado, Antje, et al. "Pre-and postoperative nutritional deficiencies in obese patients undergoing laparoscopic sleeve gastrectomy." Obesity surgery 22.6 (2012): 881-889. 12. Ledoux, Séverine, et al. "Comparison of nutritional consequences of conventional therapy of obesity, adjustable gastric banding, and gastric bypass." Obesity surgery 16.8 (2006): 1041-1049. 13. Achamrah, Najate, et al. "Micronutrient status in 153 patients with anorexia nervosa." Nutrients 9.3 (2017): 225. 14. Adams, Kathleen K., William L. Baker, and Diana M. Sobieraj. Myth Busters: Dietary Supplements and COVID-19." Annals of Pharmacotherapy (2020): 1060028020928052. 15. Manson, JoAnn E., and Shari S. Bassuk. "Vitamin and mineral supplements: what clinicians need to know." Jama 319.9 (2018): 859-860. 16. Cohen, Pieter A. "The supplement paradox: negligible benefits, robust consumption." Jama 316.14 (2016): 1453-1454.

Disease preventionHeart diseaseVitamin E (almonds, peanuts, hazelnuts, sunflower seeds, avocado) and Beta Carotene (sweet potato, dark leafy greens, cantelope, capsicum) are often studied as it is hypothesized that these antioxidants can prevent the accumulation of atherosclerotic plaques.Results of larger trials haven’t shown as profound as we had hoped for, however we have rational for this!Women’s Health Study - 39,876 healthy women took 600 IU of natural source vitamin E or a placebo every other day for 10 years. The study did not see a reduction in CVD events, however it did find a 24% reduction in total cardiovascular mortality. Women’s Antioxidant Cardiovascular Study - 8,171 women randomised.looked at beta-carotene, vitamin E, vitamin C.Modest benefit for vitamin E among women with existing cardiovascular disease.Women in the active vitamin C and E experienced fewer strokes Patients taking vitamin E had significantly more heart failure. Vitamin E was linked to a 13% higher risk of heart failure and a 21% increased risk of hospitalization for heart failureLott, E. The Journal of the American Medical Association, March 16, 2005; vol 293: pp 1338-1347. Brown, B.G. The Journal of the American Medical Association, March 16, 2005; vol 293: pp 1387-1390..https://academic.oup.com/ajcn/article/69/6/1322S/4715025a recently published analysis of clinical trials involving nearly 136,000 people who took vitamin E for one reason or another found that the overall risk of dying was greater in those who took higher doses, compared to those who took lower doses.https://www.health.harvard.edu/press_releases/facts_about_vitamineNot a huge benefit when it comes to supplementation - this was also supported in a very highly regarded medical journal called The Lancet. We know that antioxidants in fruits and vegetables, which also contain valuable fibre can have a profound impact on heart health and prevention of heart disease.Cognitive conditions (dementia, alzheimers)Oxidative stress caused by free radical damage can contribute to brain aging, cognitive deterioration and conditions such as alzheimers or dementia. .The literature has some mixed results, however again we know there is more to this complex puzzle.Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE).This study aimed to determine if vitamin E or selenium supplements used alone or in combination can prevent dementia older men.3,700 men aged 60 or older for 6 yearsUnfortunately the antioxidant supplements did not prevent the onset of Alzehimers disease.Physicians' Health Study II (PHSII), - 5,956 men age greater than 65 years.The average treatment duration was 18 years - very long!Subjects were given 50 mg beta-carotene supplements or a placebo.Long term supplementation showed positive cognitive outcomes.Statement by the Alzheimers Society regarding use of antioxidants:“Though lab-based experiments on different types of antioxidants seem promising, there is only limited support for the claims that antioxidants may protect against Alzheimer's disease from studies involving people.However, increasing fresh fruit and vegetables in the diet has numerous benefits aside from increasing antioxidant intake and is highly recommended, especially as part of a Mediterranean diet”We know there is data to suggest that eating a Med type diet (which is rich in antioxidants) is beneficial in reducing the risk of dementia. Cancer Carotenoids and breast cancer riskDietary patterns and bladder cancer- looks at fruit and veg rather than supplementsDietary Soy Isoflavones (flavanoid family) and colon cancerhttp://oncorenutrition.com/dont-fight-yo-nutrients/We know that eating a diet rich in antioxidant rich fruit and vegetables and protective against a range of different cancers. Whilst there are some gaps in the literature there are some really exciting trials currently underway.Longevity & anti-aging If we can prevent the onset of chronic diseases through increasing our intake of antioxidants, we can lead a healthier life for longer!“Free Radical Theory of Aging” (FRTA), also known as “oxidative damage theory of ageing” is a concept that free radicals and other reactive oxygen species are a byproduct of metabolism and occurs as a result of a number of exogenous factors; and it is the accumulation of damaged cells are the reason we experience age-related diseases and aging. Why antioxidants are of interest in terms of aging and longevity, is because they can block or downregulate these damaging pathways.http://www.actabp.pl/pdf/2_2000/281.pdfThere are a number of different antioxidants that are of interest when we focus on anti-aging. These include - Ascorbic acid (Vit C), alpha-tocopherol (Vit E), Ubiquinol (Coenzyme Q10), Melatonin, Curcumin, resveratrol, etc.. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982418/Ubiquinol (Coenzyme Q10)It is a unique lipid-soluble antioxidant and is essential for mitochondrial electron transport chain (ETC), which is a fancy way of referring to energy production within our cells.Benefits from heart disease risk, kidney disease, inflammation, fertility, aging, metabolic syndrome.In regard to CVD a cochrane review in 2014 found that supplementing with Co-Q10 showed a significant reduction in systolic blood pressure without improvements in other CVD risk factors, such as diastolic blood pressure, total cholesterol, LDL- and high-density lipoprotein (HDL)-cholesterol, and triglycerides.Endothelial functionInflammation - Meta-analysis explored the effect of CoQ10 on C-reactive protein (inflammatory measure), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in patients with inflammatory conditions such as multiple sclerosis, obesity, rheumatoid arthritis, diabetes, etc... It found that Co-Q10 doses between  60 to 500 mg/day for a 1-week -4-months significantly reduced production of inflammatory cytokines. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807419/#B39Food sources:Organ meats: Heart, liver and kidneySome muscle meats: Pork, beef and chickenFatty fish: Trout, herring, mackerel and sardineVegetables: Spinach, cauliflower and broccoliFruit: Oranges and strawberriesLegumes: Soybeans, lentils and peanutsNuts and seeds: Sesame seeds and pistachiosOils: Soybean and canola oilResveratrol (RSV) - A polyphenolic compound that stimulates cell defense pathways.Protects these plants against UV rays and some fungal infections.It has been hypothesised that it is RSV that is responsible for  the ‘French paradox’ - low rates of heart disease in France, despite a diet rich in cheese and red wine.There is evidence that resveratrol may be beneficial in the context of diabetes, CVD and cancer.Meta Analysis which looked at the evidence regarding RSV across a number of different species. It found that there are a few species that found life extension in response to RSV.Metabolic functionhttps://academic.oup.com/biomedgerontology/article/67/12/1307/605425https://www.sciencedirect.com/science/article/pii/S155041311100386XBe careful of high doses of resveratrol if history of breast cancerFood sources: Red wine, grapes, peanuts, pistachios, dark choc, cacao, strawberries 

I was shocked when I learned over 90% of the vitamin C on the market today is NOT true vitamin C, but a synthetic form called ascorbic acid. And that most of the time, ascorbic acid is derived from GMO corn in China and processed using volatile acids. How do you know the difference between real vitamin C and the synthetic kind? All you have to do is check the ingredient label on your vitamin C supplement. If it says “ascorbic acid” you’re definitely going to want to learn the important differences from the founder of the Root Cause Protocol, Morely Robbins in this podcast! Ascorbic acid is NOT the same as vitamin C. There are important differences that you need to know about! So listen in and share this podcast so we can spread the good word! P.S. Don’t let the big words at the beginning of the podcast scare you, it’s critically important to understand the nuances and we get to the suuuper practical take-home message at the end. You’re not going to want to miss it!

THE RESULTS OF A 16 YEARS STUDY ON VITAMIN  C CONSUMPTION IN HUMANS JUST ENDED, AND THE RESULTS ARE AMAZING.  A SUBSTANTIAL DECREASE IN ALL CAUSE MORTALITY..YES YOU LIVE LONGER AND HEALTHIER. WE WILL GET INTO ALL OF THE DETAILS TODAY. TUNE IN. Tune in every day to hear Dr. Len Brancewicz of The Nutrition Shoppe discuss today's hottest health topics and news from a complimentary perspective.  From colds to cancer and everything in between, Dr. Len can offer honest advice that makes sense. As a Registered Pharmacist (RPh), Certified Clinical Nutritionist (CCN), Doctor of Naturopathic Medicine (NMD), and a homeopath, Dr. Len has over 35 years experience in helping to keep you and your family healthy and happy. Call the show today to ask about your most pressing health concerns! Visit us on the web at www.TheNutritionShoppe.net or call  678-228-8900    to set up a personalized consultation, shop products, or ask questions! ---- Tags: health, natural health, supplements, vitamins, prescriptions, medications, pharmacist, naturopath,

Laura Powers talks with Wendy Meyers, Functional Diagnostic Nutritionist and Founder of Live to 110. She focuses heavy metals and detoxification hair mineral analysis to create custom nutrient therapy programs for people. She uses hair mineral analysis and urine tests and some other tests to diagnose what is going on for people. Hair tests give a three-month average of what has been going on with a person. We discussed the results with Laura. The hair mineral results are posted on the media page of Laura’s website. Laura had what is called a calcium shell and when the body goes into stress, the body sheds calcium. It desensitizes your body while you are trying to protect yourself. People need magnesium to process calcium. You can take magnesium supplements to support this. We need five time our bodyweight in pounds in milligrams. We discussed how empaths and sensitives will respond much more to environmental stress then other people. Unless you do something to correct these imbalances they will remain or get worse. Wendy talked about how we are all works in progress and it can take 2-3 years for us to stabilize after getting so low. Adrenal fatigue will cause calcium depletion and copper toxicity. Wendy talked about we need sea salt because of all the great minerals in it. Table salt has been stripped of all the other minerals so sea salt is what we really need. Add sea salt and potassium bicarbonate or cream of tartar before bed is great for adrenal fatigue. Laura talked about from a western medicine perspective she is really healthy but a healthy diet and lifestyle is not enough. Also, to be truly healthy we need to look beyond lack of illness and see are our bodies getting what we need. Hair Mineral Analysis will show imbalances in the body before there are symptoms. Wendy also addressed how if you feel you need stimulants to get through the day, that is a sign that you are depleted. Copper regulation is very important. Copper is metal that we need in small amounts and many women who have copper issues are overweight. Copper toxicity symptoms include acne, ovarian cysts and easy bruising, low or high hormones, brain fog, anxiety, insomnia, infertility hair loss, vein issues and hemorrhoids. We get excess copper from hormone replacement therapy, IUDs, also adrenal fatigue promotes the buildup of copper in the body. When you have adrenal fatigue, your body cannot release the chemical that helps us release copper. Having copper is directly tied to liver congestion so anything you do to heal with liver will also help us with copper toxicity. For liver issues, avoid vitamin D. Wendy recommend a blood test to see if you need vitamin D. Other things to heal the liver are to avoid ascorbic acid (synthetic vitamin C) and high fructose corn syrup. Cod Liver Oil can help as well as food based vitamin C and a B complex. Ascorbic acid is particularly toxic for adrenal fatigue and liver problems. Laura also has high iron which causes inflammation and goes back to adrenal fatigue. We also talked about leaky gut syndrome and candida and how it can take a year to it. In order to heal candida, you have to heal copper issues because the environment conducive to its growth is still present. Copper destroys the ability to absorb nutrients. It can be detoxed and it can take 2-3 years to clear the copper. Slippery elm is good for healing the gut as well. For candida, first you need take a biofilm disrupter first, also have to do a parasite cleans, then a bacterial cleanse, and then a yeast cleanse in order to get rid of candida. Laura had high uranium levels and is likely from Fukushima. These can be detoxed in an infrared sauna. Aluminum is from commercial deodorant, to salt and to drinking water. Laura also had high nickel content which is called the suicide medal and is found it red tea and mint tea has a lot of aluminum it in so both of those teas are good to avoid if you have high nickel or aluminum in the body. Near infrared sauna use lig

Learn about the difference between natural and synthetic vitamins, how you can look out for them, how detrimental they are (synthetic) and the importance of whole-food vitamins

An interview with Joshua Burns, PhD, about the paper, Ascorbic acid for Charcot–Marie–Tooth disease type 1A in children: a randomized, double-blind, placebo-controlled, safety and efficacy trial in Lancet Neurol. 2009 Jun;8(6):537-44. Interviewed by Ted Burns, MD.

An interview with Joshua Burns, PhD, about the paper, Ascorbic acid for Charcot–Marie–Tooth disease type 1A in children: a randomized, double-blind, placebo-controlled, safety and efficacy trial in Lancet Neurol. 2009 Jun;8(6):537-44. Interviewed by Ted Burns, MD.

An interview with Joshua Burns, PhD, about the paper, Ascorbic acid for Charcot–Marie–Tooth disease type 1A in children: a randomized, double-blind, placebo-controlled, safety and efficacy trial in Lancet Neurol. 2009 Jun;8(6):537-44. Interviewed by Ted Burns, MD.

The actions of the reductant ascorbic acid on rat neocortical neurons in vitro was investigated by means of intracellular recordings. At a concentration (500 μM), which reduced the magnitude of dopamine degradation in oxygen-saturated saline solutions by about 50%, ascorbic acid reversibly depressed synaptic potentials and enhanced direct excitability of cortical neurons. The latter effect was not reversible within the observation period. Ascorbic acid did not alter membrane potential and input resistance of the neurons. On the basis of our results we conclude that ascorbic acid is not a useful reductant to avoid oxidation of catecholamines in oxygen-saturated solutions used in electrophysiological experiments in vitro.