Podcasts about Benzodiazepine

  NEW SUBSCRIPTION INTERFACE THINGAMABOB!   You can now find our subscription page at GeorgeHrab.com at this link. Many thanks to the majestic Evo Terra for his assistance.   THE SHOW NOTES   Easter is here, Easter is weird Intro Is anyone out there? Interesting Fauna      - Clobazam- and Benzodiazepine-exposed Atlantic Salmon Religious Moron of the Week      - Melissa Ganey English Ask George      - Hold music? from Michael in Seattle Damian Handzy's Facts That'll Fuck Y'up      - Sourdough, Coldplay, Lincoln, Turing, more… Tell Me Something Good      - Hacked Crosswalks Geo Solo in Nazareth next Saturday Show Close .........................   EVENTS ON THE SCHEDULE  April 26 Nazareth Center for the Arts “George Hrab: So Wry, Solo” 7:30 .........................   Get George's Music Here  https://georgehrab.hearnow.com https://georgehrab.bandcamp.com ................................... SUBSCRIBE! You can sign up at GeorgeHrab.com and become a Geologist or a Geographer. As always, thank you so much for your support! You make the ship go. ................................... Sign up for the mailing list: Write to Geo! Check out Geo's wiki page, thanks to Tim Farley. Have a comment on the show, a Religious Moron tip, or a question for Ask George? Drop George a line and write to Geo's Mom, too!

"Designer benzodiazepines" are lab-created chemical derivatives of prescription benzodiazepines. They have not been approved for medical use and there is limited information on their safety and toxicity. More potent than their prescription counterparts, this subset of novel psychoactive substances have been growing in popularity in recent years and pose the potential for dangerous levels of intoxication. In this podcast, Dr. Sahil Munjal, program director of the Atrium Health Wake Forest Baptist psychiatry residency program, leads a discussion of the article “Clinical Management of Designer Benzodiazepine Intoxication: A Systematic Review," with his coauthors Dr. Gregory Noe, Katelyn Li, and Nicholas McDuffee. They provide an overview of designer benzodiazepines in comparison to prescription benzodiazepines and describe the findings from their review of 35 case reports. They discuss clinical presentations of designer benzodiazepine intoxication, common approaches to clinical management, and key takeaways from their review of the literature. Their article appears in the March-April 2025 issue of The Journal of Clinical Psychopharmacology.

Si moltiplicano i risvolti dell'indagine legata a Paola Pettinà, la 46enne vicentina - arrestata a dicembre - alla quale più famiglie della zona affidavano persone anziane colpite poi da inspiegabili crolli nella salute. Oggi la notifica delle ordinanze decise della Procura dopo le ispezioni in più farmacie che elargivano psicofarmaci alla donna con troppa leggerezza.

“Behind the Evidence” is the addiction medicine podcast of the Grayken Center for Addiction at Boston Medical Center, and a project of the Center's free bimonthly newsletter Alcohol, Other Drugs, and Health: Current Evidence (AODH). This episode was recorded in June 2024 and features an interview with Joao P. De Aquino, MD on his article published in the American Journal of Drug and Alcohol Abuse: “The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies.” And an interview with Donovan Maust, MD on his article in JAMA Network Open: “Benzodiazepine discontinuation and mortality among patients receiving long-term benzodiazepine therapy.” Click the following links to read AODH's summaries of Dr De Aquino and Dr. Maust's articles.Also discussed: Christine PJ, Lodi S, Hsu HE, et al. Target trial emulation for comparative effectiveness research with observational data: Promise and challenges for studying medications for opioid use disorder. Addiction. 2024;119(7):1313-1321.Hosts: Honora L. Englander, MD and Marc R. Larochelle, MDProduction: Raquel Silveira, MBAEditing: Casy Calver, PhDMusic and cover art: Mary Tomanovich, MAMiriam Komaromy, MD is the Medical Director of the Grayken Center for Addiction, and co-Editor-in-Chief of AODH, together with David Fiellin, MD.Learn more about AODH and subscribe for free at www.aodhealth.org“Behind the Evidence” is supported by the Grayken Center for Addiction at Boston Medical Center. It is intended for educational purposes only, and should not be considered medical advice. The views expressed here are our own, and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

 You're at the end of your rope, so you head to the pharmacy for the help you so desperately need to sleep. But wait, you aren't sure if it's safe, if it works, and if there's a better way.  Stay tuned to learn about the benefits, side effects, and risk of sleep aids.   I'm Dr.Vickie Petz Kasper. If you're ready to take control of your health, you're in the right  place. I'll give you practical steps to start your own journey toward better health because healthy looks great on you.  This is episode 159, Sleeping Pills and Potions. What works and what doesn't. You know that poor sleep is associated with heart disease, cancer, diabetes, obesity, immune dysfunction, high blood pressure, anxiety, depression, fatigue, irritability, and good grief, I could go on and on. So, taking something to help you sleep sounds like a good idea, right?  Today, we'll discuss what you need to know before you go and get a prescription, supplement, or over the counter sleeping aid. Look, we have to sleep. Our very lives and health depend on it. But the struggle is real. Insomnia is one of the most common symptoms people go to the doctor or health care provider for treatment.   And what if I told you that good sleep is possible without medications? Well, it is. In fact, the first line treatment recommended to treat insomnia is not medication. The standard recommendation for managing insomnia is to eliminate things that go bump in the night and keep you awake.  Or, to treat underlying diseases that disrupt sleep. It's not recommended to start with behavioral therapy or medications until these other things are maximized. Ha! But good luck with that. If you go to your primary care provider and you don't get a prescription, I'll buy you a cup of coffee and we can both stay awake.  And, if you think you need to see a specialist, then you'll probably get to spend the night in a sleep lab hotel hooked up to a bunch of wires and you may get answers, like, a CPAP, and that's important if you have sleep apnea, but if not, you might not even hear from them. No wonder you're looking for a good solution to sleep.  And though medications are not the first line recommendation, that is the topic of today's episode. So let's get to it. We're going to start with prescription medications, then we'll talk about over the counter medications and wrap up with supplements.  There are three classes of drugs approved to treat insomnia. Benzodiazepine receptor agonist, histamine receptor antagonist, and melatonin receptor agonist. Listening to all that medical jargon may be sufficient to put you to sleep. But wait, let me explain. You'll understand more after we go to mini medical school today and learn about receptors.  These are made up of proteins and they receive chemical signals that produce a response.  Let me give you this analogy. You've got a lamp sitting on an end table, but it's not plugged in, so there's no light. And when you stick those two prongs into the socket, behold, now you can sit and read. And that's kind of how a receptor works. The plug fits into the plug in. So an agonist is like the plug. It fits. It turns it on. It lets the electricity flow.  But, if you had a toddler in the house, you might want to plug in one of those little plastic things so he doesn't stick a butter knife in there and get shocked. So that would be an antagonist.  Okay, now wake up and pay attention. We've got three classes of drugs to look at. Benzo receptor agonist and melatonin agonist. That plug in and histamine receptor antagonist that block the plugin. And then there's another category called other. We'll just call that the clapper, you know, clap, clap. And the light comes on, clap, clap, and the light goes off.  There are eight drugs in the benzodiazepine receptor agonist family. And the first five are about my age, you know, born in the 60s. They are Estazolam, which is Prosom, Florazepam, which is Dalmane, Quamazepam, which is Doral, Temazepam, which is Restoril and Triazolam, which is Halcion. Now the millennials aren't benzos, but they're still benzo receptor agonist. And you know, this generation got way more complicated spelling their kids' names, so I'm probably gonna have to sound them out like a first grade teacher on the first day of school.  Eszopiclone is Lunesta, Zaleplon is Sonata. Zolpidem is Ambien.  Those older drugs are crankier and cause more dependence although Restoril is the nicest in the category. There are other benzos which are technically prescribed for anxiety and  some people do use them to help them sleep. Do they work? Here's what the data says for the old guys. They help you fall asleep faster. A whole whopping 10 minutes faster. And they increase total sleep time by half an hour to an hour. That's it.  What about risk? Well, they make you sleepy, which is kind of the point, but also they can make you dizzy, which can make you fall if you get up and go to the bathroom during the night. And if you mix them with opioids, the reaction can be fatal.   Now, the younger guys function about as well as the older ones, but they have shorter half lives, so their effects don't wear out their welcome so much with daytime grogginess. And they aren't so deadly when socializing with opioids. But rarely, they do some bizarre things like compel you to shop or gamble in the middle of the night. All for 10 minutes faster to go to sleep and half hour to an hour longer sleeping.  Okay, clap on, clap off, let's talk about the other drugs.  These are dual orexin receptor antagonists.  Affectionately known as D O R A or Dora.  The first one is Suvarexant, which is called Belsomra. The next one is Derodorexant, which sounds a lot like deodorant to me, and that's exactly what I'm gonna call it because the brand name is Quviviq. And finally, there is Limboxerant, which has a really cool brand name, Dayvigo.  What? You've never heard of any of these? Well, that's probably because they're slightly less effective than the other drugs. They help you go to sleep seven minutes faster. But the main side effect is sleepiness, and people generally say they slept better. The next topic in pharmacology class in mini medical school is the histamine antagonist. You know, the little plastic thing that goes in the wall socket so your toddler doesn't.  Doxepin is a tricyclic antidepressant that functions this way, and even in low doses it causes the desirable effect of drowsiness. So, it's approved for the treatment of drowsiness deficit.  Unfortunately, there are some drugs it doesn't play nice with. But, it does increase sleep time by Drum roll please! 25 to 30 minutes. Womp, womp, womp. And, it helps people stay asleep toward the end of the sleep cycle.    And I think this underscores why one size does not fit all and prescriptions should be customized for individual needs.  The last class of drugs approved for the treatment of insomnia makes a lot of sense.  Ramelteon is a melatonin receptor agonist and the brand name Rosarem, get it? REM, R E M, as in rapid eye movement sleep. It's got a good mechanism of action, a good name. Problem is, it doesn't work any better than placebo. So, you can skip the potential for fatigue, nausea, and worsening of liver disease and just take a sugar pill.  So, am I saying it doesn't work at all? Of course not. Why would it be approved if it didn't work? Well, it's not in Europe, but it does work to lengthen sleep time by a grand total of seven minutes. And I don't know about you, but it's going to take more than seven minutes to get rid of the bags under these eyes.  So that's the gamut of drugs approved for the treatment of insomnia in the United States. But wait, there's more. Just because the FDA doesn't approve something for a particular indication, that doesn't mean that doctors can't prescribe it. And sometimes, off label prescribing is a really good thing, though it's a set up for a knock down, drag out fight with your insurance company for coverage. In addition to using the antidepressant Doxepin, many doctors prescribe other antidepressants for sleep. Things like Amitriptyline and Trazodone, even though the American Academy of Sleep Medicine advises against it because of side effects and no data showing that it works. Now, I always recommend that you consult with your health care provider regarding your medications. Always, always, always.  But, I also recommend that they consult with up to date society recommendations and guidelines. That's just fair. And while they're at it, they should look at the potential adverse reactions. So, now maybe you've decided to skip the copay and just help yourself to the sleep aid aisle of the pharmacy. You could even ask the pharmacist to guide you, and I recommend that. There are two over the counter medications approved to treat insomnia. They are diphenhydramine, commonly known as Benadryl, and doxalamine, commonly known as Unisom. Side note, over the counter medications are regulated  FDA, And both of these drugs are histamine blockers. Therefore, all of the fun side effects that come with that, like dry mouth, GI distress, dizziness, trouble emptying your bladder, and of course, sedation, which is the desired side effect. These medications are often combined with things like Advil or Tylenol with an added P. M. at the end, so you know what's in store for you. And here's what's in store for diphenhydramine. 8 less minutes to fall asleep and 12 more minutes of sleep. And for doxylamine, there's no data available. That's it. That's what we've got. So, maybe now you've decided just to take matters into your own hands and look for a supplement. And because you've listened to my previous podcast episode about dementia, you're gonna skip right over the Prevagen, right? Promise me. Now, in the supplement section, you're going to walk in understanding that claims, concentrations, and ingredients are not guaranteed. They're not regulated. They are, generally speaking, considered safe and ineffective. You heard that right. Safe. And ineffective. But what about melatonin? You swear it works, but does it?  Maybe. It is sedating in about 10 percent of people and in everyone else, it shifts the sleep phase. So, there is a place for that such as jet lag, and I have an episode on jet lag in the show notes.  But even though it may help you drift off to sleep, it probably isn't going to help you stay asleep. The half life is less than an hour, and in some people it causes stomach cramps, irritability, and even depression. It's best used in combination with other things that regulate your circadian rhythm. More to come on that. But a big one is light. And so this probably would be a great time to tell you about some exciting news I have for you. I have an upcoming series of live webinars to talk about six hidden things that keep you tossing and turning at night.   And soon you'll have access to an online course called Unlock the Secret to Sleep, your personal sleep solution. I have been working so hard on this for so long that I cannot wait to share it with you.  I want to help you reset your sleep and get your Z's. Now there are other supplements labeled as sleep aids and most of them again are safe and probably not effective. The exceptions on safety are kava and valerian root. Both of those have been associated with liver damage. Now it's rare, but it's very serious. Other things you might find on this aisle are chamomile, Glycine, Gryphonia, Hops,  , Kava, L theanine, Lavender, , Passionflower, Nightshade, Skullcap, Strymonium, Tryptophan, , and Wild Jujube Seeds.  They're all equally effective and work every bit as well as a sugar pill, but hey, sugar pills can have powerful placebo effects. And one last thing I want to mention, and that is cannabis. Bottom line is there's not enough research to say one way or another, whether it works. It does have the potential for addiction and it's not legal everywhere. So there's that.  But also it's a problem that if you quit, you'll likely experience sleep disturbances that can last for several months.     The bottom line is, I want you to know that you shouldn't have to choose between serious health consequences of poor sleep and the side effects and risk of sleeping pills and potions.  If you suffer from insomnia, I do encourage you not to stop any medications without medical supervision and to have an honest conversation with your doctor. And if they want access to my resources, just give them my email address. I'm happy to share and they're 100 percent legit, but if good sleep eludes you, I want you to know while there's no magic pill for perfect sleep, there is a proven path to natural, restorative rest that can transform your life. Imagine waking up energized, focused, and ready to tackle your day without relying on sleeping pills or potions.  Are you tired of tossing and turning at night? Desperately wishing for deep, restful sleep?  I'm hosting two exclusive live webinars where I'll share my evidence based approach to achieving consistent quality sleep. Join me on March 3rd or March 5th to discover how to fall asleep naturally. and wake up refreshed, practical strategies to boost your energy and mental clarity, and solutions to common sleep challenges that keep you awake at night.  Plus you'll get a chance to ask your most pressing sleep questions during a live Q& A session. So don't miss this opportunity. To revolutionize your sleep. Click the link in the show notes to save your spot now. Registration is required. And make sure you're on my email list to receive exclusive pre webinar insights and special bonuses. Your journey to better sleep starts here. Sign up right now and let's transform your nights and supercharge your days.  Because good sleep is crucial for good health and healthy looks great on you.   RESOURCES: FREE, live sleep masterclass registration Jet Lag Does Prevagen work? Why doctors prescribe a pill Meet Aunt Edna - Your holiday survival stress guide

Join Dr. Andy Cutler as he talks with Dr. Jeffrey Strawn about how clinicians can determine the appropriate scenarios for benzodiazepine deprescribing, best practices for benzodiazepine tapering, and how to balance patient preferences to ensure best outcomes.  Jeffrey R. Strawn, MD is a Professor and Associate Vice Chair of Research in the Department of Psychiatry and Behavioral Neuroscience at the University of Cincinnati (UC) College of Medicine, the Assistant Director of Clinical and Translational Research in the Center for Clinical & Translational Science and Training at UC, and an Associate Professor in the Department of Pediatrics at UC and Cincinnati Children's Hospital Medical Center.   Andrew J. Cutler, MD is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and holds the position of Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.  Save $100 on registration for 2025 NEI Spring Congress with code NEIPOD25  Register today at nei.global/spcongress25p  Never miss an episode!

Lo stress, negli anni 2000, è diventato una costante silenziosa, alimentato da un mondo sempre più veloce e disconnesso. Per affrontarlo, molti si rifugiano in soluzioni rapide e insidiose: l'alcol per spegnere l'ansia, le benzodiazepine per congelare le emozioni e il cibo, spesso ipercalorico, per cercare conforto. È un cerchio vizioso che anestetizza il disagio senza risolverlo, lasciando cicatrici profonde nel corpo e nella mente. La verità è che queste strategie non gestiscono lo stress, lo nascondono. La sfida è trovare strumenti più sani e autentici, come il movimento, le relazioni vere e il coraggio di affrontare il cambiamento. ⭐️ Scopri il VideoCorso "PREVENZIONE PRATICA": https://lifeology.it/prevenzione-pratica/ ⭐️ ⭐️ Vai alla VideoLezione Gratutia "PREVENZIONE EFFICACE": https://lifeology.it/prevenzione-sq/ ⭐️ ⭐️ Scopri il progetto MIDNIGHT MELODY, in collaborazione con il Dott. Valerio Rosso e il Dott. Gennaro Romagnoli: https://nutritonic.shop/ ⭐️ ⭐️ Scopri “BODY BRAIN ROUTINE”, il nuovo libro di Valerio Rosso, Gennaro Romagnoli e Marco Zamboni: https://lifeology.it/bodybrain-routine/ ⭐️ ⭐️ Scopri MoveMotivation, un'esperienza trasformativa per far emergere e consolidare la motivazione all'attività fisica: https://lifeology.it/move-motivation/?utm_source=yt_ads_ret&utm_medium=mm_vale_1⭐️ ⭐️ Scarica GRATIS la tua copia di “psiq: Lifestyle Principles” ⭐️ È un eBook che ti permetterà di scoprire i principi della Lifestyle Medicine e migliorare drasticamente la tua vita: https://psiq.it/lifestyle-principles/ ⭐️ ⭐️Iscriviti subito a MINDFITNESS, un mini corso GRATUITO in cui imparerai delle strategie pratiche per ottimizzare il tuo cervello: https://psinel.com/br-iscrizione-mini-corso-mindfitness/ ⭐️ ⭐️ Scopri “psiq: Salute Mentale: Istruzioni per l'uso”, il nuovo libro del Dr. Valerio Rosso: https://bit.ly/psiqVR oppure anche https://www.psiq.it ⭐️ ⭐️ Accedi adesso GRATUITAMENTE alla VideoLezione "La Verità Scientifica sugli Integratori": https://lifeology.it/integratori-sq/ ⭐️ Il Dott. Valerio Rosso è un medico specialista in neuroscienze e un pioniere italiano nella divulgazione della medicina dello stile di vita, riconosciuto per il suo impegno nella diffusione on line di informazioni basate su evidenze scientifiche. Il Dott. Rosso è autore di numerosi articoli scientifici e divulgativi, e partecipa regolarmente a conferenze e meeting come relatore, condividendo le sue conoscenze sui benefici di una vita sana e attiva. La sua dedizione alla medicina preventiva e al miglioramento delle performance cognitive e fisiche lo ha reso un punto di riferimento nel campo. Con una visione olistica della salute, il Dott. Rosso promuove un approccio che combina dieta, esercizio fisico, gestione dello stress, relazioni, controllo dell'ambiente e lotta alle DIPENDENZE per ottimizzare la qualità della vita delle persone che lo seguono sul suo ecosistema digitale.

Si allargano le indagini attorno alla posizione di Paola Pettinà, l'ex commessa 46enne domiciliata a Sandrigo ma originaria di Bolzano Vicentino accusata, sinora, della morte di un'anziana e del tentativo di omicidio di almeno altre quattro persone nell'est vicentino. Ma sarebbero altrettanti i decessi "sospetti" attorno ai quali si stanno concentrando le attività degli inquirenti.

In this episode, we explore strategies for discontinuing benzodiazepines in hospitalized elderly patients. We discuss a recent Israeli study that tested two interventions during inpatient stays. Can a simple hospital-based intervention lead to successful long-term medication changes? Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CMEs: Quick Take Vol. 61 Stopping Benzodiazepines and Z-Drugs in Hospitalized Elderly Patients

In this episode of CUBIST, the host discusses a study titled “Prescription Patterns After Mild Traumatic Brain Injury in U.S. Military Service Members,” written by Lauren Earyes and her colleagues at TBICoE and published in Military Medicine in July 2024. In addition, Ms. Earyes, lead author and health systems specialist at TBICoE, joins the podcast. Article Citation: Earyes, L., Agimi, Y., & Stout, K. (2024). Benzodiazepine Prescription Patterns After Mild Traumatic Brain Injury in U.S. Military Service Members. Military medicine, 189(9-10), 1931–1937. https://doi.org/10.1093/milmed/usad443 Article LINK: https://pubmed.ncbi.nlm.nih.gov/39028226/ CUBIST is a podcast for health care providers produced by the Traumatic Brain Injury Center of Excellence. We discuss the latest research on traumatic brain injury most relevant to patient care. For more about TBI, including clinical tools, go to www.health.mil/TBICoE or email us at dha.TBICoEinfo@health.mil. The views and opinions of findings and or devices discussed in this podcast are those of the host, subject matter experts, and or guests. Facts represented constitute our understanding at the time of the podcast, whereas updated factual information may be developed. They should not be construed as pronouncing an official Department of Defense's position, policy, decision, or endorsement. The hosts and guests of CUBIST may be defense contract personnel who support TBICoE. The status of all hosts and guests will be identified during introductions to the podcast. Our theme song is “Upbeat-Corporate' by WhiteCat, available and was used according to the Creative Commons Attribution-Noncommercial 4.0 license.

In this episode of CUBIST, the host discusses a study titled “Prescription Patterns After Mild Traumatic Brain Injury in U.S. Military Service Members,” written by Lauren Earyes and her colleagues at TBICoE and published in Military Medicine in July 2024. In addition, Ms. Earyes, lead author and health systems specialist at TBICoE, joins the podcast. Article Citation: Earyes, L., Agimi, Y., & Stout, K. (2024). Benzodiazepine Prescription Patterns After Mild Traumatic Brain Injury in U.S. Military Service Members. Military medicine, 189(9-10), 1931–1937. https://doi.org/10.1093/milmed/usad443 Article LINK: https://pubmed.ncbi.nlm.nih.gov/39028226/ CUBIST is a podcast for health care providers produced by the Traumatic Brain Injury Center of Excellence. We discuss the latest research on traumatic brain injury most relevant to patient care. For more about TBI, including clinical tools, go to www.health.mil/TBICoE or email us at dha.TBICoEinfo@health.mil. The views and opinions of findings and or devices discussed in this podcast are those of the host, subject matter experts, and or guests. Facts represented constitute our understanding at the time of the podcast, whereas updated factual information may be developed. They should not be construed as pronouncing an official Department of Defense's position, policy, decision, or endorsement. The hosts and guests of CUBIST may be defense contract personnel who support TBICoE. The status of all hosts and guests will be identified during introductions to the podcast. Our theme song is “Upbeat-Corporate' by WhiteCat, available and was used according to the Creative Commons Attribution-Noncommercial 4.0 license.

pWotD Episode 2643: Stiff-person syndrome Welcome to Popular Wiki of the Day, spotlighting Wikipedia's most visited pages, giving you a peek into what the world is curious about today.With 239,235 views on Saturday, 27 July 2024 our article of the day is Stiff-person syndrome.Stiff-person syndrome (SPS), also known as stiff-man syndrome, is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms.SPS occurs in about one in a million people and is most commonly found in middle-aged people. A small minority of patients have the paraneoplastic variety of the condition. Variants of the condition, such as stiff-limb syndrome, which primarily affects a specific limb, are often seen.SPS was first described in 1956. Diagnostic criteria were proposed in the 1960s and refined two decades later. In the 1990s and 2000s, the role of antibodies in the condition became clearer. SPS patients generally have glutamic acid decarboxylase (GAD) antibodies, which seldom occur in the general population. In addition to blood tests for GAD, electromyography tests can help confirm the condition's presence.Benzodiazepine-class drugs are the most common treatment; they are used for symptom relief from stiffness. Other common treatments include baclofen, intravenous immunoglobin, and rituximab. Limited but encouraging therapeutic experience of haematopoietic stem cell transplantation exists for SPS.This recording reflects the Wikipedia text as of 01:55 UTC on Sunday, 28 July 2024.For the full current version of the article, see Stiff-person syndrome on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm neural Kimberly.

Benzodiazepine use in relation to long-term dementia risk and imaging markers of neurodegeneration: a population-based study 

John Cooke, RTÉ Reporter

Michael Meyden, a 57-year-old resident of Lake Oswego, was sentenced to two years in prison for drugging his daughter and her friends with fruit smoothies laced with sleeping medication. Meyden's actions during a sleepover last summer have shocked the community and led to widespread condemnation. The incident occurred last summer when Meyden organized a sleepover for his 12-year-old daughter and her three friends. According to Meyden, the children did not go to bed by 11 p.m. as he had hoped, prompting him to take drastic measures to ensure they got some rest. "I wanted them to be well-rested for the next day, but I also wanted to get some sleep myself," Meyden explained during his sentencing. Meyden decided to lace fruit smoothies with a sleeping medication, which he then offered to the girls. Two of the friends drank the smoothies and soon fell unconscious. The third girl, suspicious of the situation, declined the drink and texted a family friend for help after witnessing Meyden's unusual behavior. The quick-thinking girl alerted a family friend by text message after seeing Meyden return to check if the girls were asleep. Meyden's actions included moving the arm of one girl, repositioning another, and putting his finger under one's nose to check for breathing. The family friend promptly picked up the girl and alerted her parents, who then contacted the families of the other girls. Upon testing at a local hospital, all three girls, including Meyden's daughter, were found to have benzodiazepine in their systems. Benzodiazepine is a medication commonly used to treat insomnia and anxiety. During the sentencing, the courtroom heard emotional statements from the families of the affected children. One mother passionately addressed Meyden, saying, "No decent parent feels the need to drug their own child and her friends. No decent parent feels the need to go down and confirm children are unconscious. No decent parent puts their hands on drugged and unconscious young girls without nefarious intent." Meyden, expressing remorse, told the court, "My whole life is destroyed. Everything that was important to me up until that point is gone." Meyden pleaded guilty to three felony counts of causing another person to ingest a controlled substance, leading to his two-year prison sentence. The incident has left the Lake Oswego community reeling, with many parents expressing disbelief and concern over the safety of their children. Local authorities have emphasized the importance of vigilance and communication among families to prevent similar incidents in the future. This case serves as a stark reminder of the importance of trust and safety in parenting. The community continues to grapple with the implications of Meyden's actions and the impact on the young girls involved. Michael Meyden's sentencing marks a critical step in addressing the gravity of his actions. As the families affected begin the healing process, the broader community remains united in ensuring the safety and well-being of its children. For more updates on this story and other local news, stay tuned to our website and social media channels. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on The Downfall of Diddy, The Karen Read Trial, Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, Justice for Harmony Montgomery, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, and much more! Listen at https://www.truecrimetodaypod.com

Michael Meyden, a 57-year-old resident of Lake Oswego, was sentenced to two years in prison for drugging his daughter and her friends with fruit smoothies laced with sleeping medication. Meyden's actions during a sleepover last summer have shocked the community and led to widespread condemnation. The incident occurred last summer when Meyden organized a sleepover for his 12-year-old daughter and her three friends. According to Meyden, the children did not go to bed by 11 p.m. as he had hoped, prompting him to take drastic measures to ensure they got some rest. "I wanted them to be well-rested for the next day, but I also wanted to get some sleep myself," Meyden explained during his sentencing. Meyden decided to lace fruit smoothies with a sleeping medication, which he then offered to the girls. Two of the friends drank the smoothies and soon fell unconscious. The third girl, suspicious of the situation, declined the drink and texted a family friend for help after witnessing Meyden's unusual behavior. The quick-thinking girl alerted a family friend by text message after seeing Meyden return to check if the girls were asleep. Meyden's actions included moving the arm of one girl, repositioning another, and putting his finger under one's nose to check for breathing. The family friend promptly picked up the girl and alerted her parents, who then contacted the families of the other girls. Upon testing at a local hospital, all three girls, including Meyden's daughter, were found to have benzodiazepine in their systems. Benzodiazepine is a medication commonly used to treat insomnia and anxiety. During the sentencing, the courtroom heard emotional statements from the families of the affected children. One mother passionately addressed Meyden, saying, "No decent parent feels the need to drug their own child and her friends. No decent parent feels the need to go down and confirm children are unconscious. No decent parent puts their hands on drugged and unconscious young girls without nefarious intent." Meyden, expressing remorse, told the court, "My whole life is destroyed. Everything that was important to me up until that point is gone." Meyden pleaded guilty to three felony counts of causing another person to ingest a controlled substance, leading to his two-year prison sentence. The incident has left the Lake Oswego community reeling, with many parents expressing disbelief and concern over the safety of their children. Local authorities have emphasized the importance of vigilance and communication among families to prevent similar incidents in the future. This case serves as a stark reminder of the importance of trust and safety in parenting. The community continues to grapple with the implications of Meyden's actions and the impact on the young girls involved. Michael Meyden's sentencing marks a critical step in addressing the gravity of his actions. As the families affected begin the healing process, the broader community remains united in ensuring the safety and well-being of its children. For more updates on this story and other local news, stay tuned to our website and social media channels. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on The Downfall of Diddy, The Karen Read Trial, Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, Justice for Harmony Montgomery, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, and much more! Listen at https://www.truecrimetodaypod.com

Michael Meyden, a 57-year-old resident of Lake Oswego, was sentenced to two years in prison for drugging his daughter and her friends with fruit smoothies laced with sleeping medication. Meyden's actions during a sleepover last summer have shocked the community and led to widespread condemnation. The incident occurred last summer when Meyden organized a sleepover for his 12-year-old daughter and her three friends. According to Meyden, the children did not go to bed by 11 p.m. as he had hoped, prompting him to take drastic measures to ensure they got some rest. "I wanted them to be well-rested for the next day, but I also wanted to get some sleep myself," Meyden explained during his sentencing. Meyden decided to lace fruit smoothies with a sleeping medication, which he then offered to the girls. Two of the friends drank the smoothies and soon fell unconscious. The third girl, suspicious of the situation, declined the drink and texted a family friend for help after witnessing Meyden's unusual behavior. The quick-thinking girl alerted a family friend by text message after seeing Meyden return to check if the girls were asleep. Meyden's actions included moving the arm of one girl, repositioning another, and putting his finger under one's nose to check for breathing. The family friend promptly picked up the girl and alerted her parents, who then contacted the families of the other girls. Upon testing at a local hospital, all three girls, including Meyden's daughter, were found to have benzodiazepine in their systems. Benzodiazepine is a medication commonly used to treat insomnia and anxiety. During the sentencing, the courtroom heard emotional statements from the families of the affected children. One mother passionately addressed Meyden, saying, "No decent parent feels the need to drug their own child and her friends. No decent parent feels the need to go down and confirm children are unconscious. No decent parent puts their hands on drugged and unconscious young girls without nefarious intent." Meyden, expressing remorse, told the court, "My whole life is destroyed. Everything that was important to me up until that point is gone." Meyden pleaded guilty to three felony counts of causing another person to ingest a controlled substance, leading to his two-year prison sentence. The incident has left the Lake Oswego community reeling, with many parents expressing disbelief and concern over the safety of their children. Local authorities have emphasized the importance of vigilance and communication among families to prevent similar incidents in the future. This case serves as a stark reminder of the importance of trust and safety in parenting. The community continues to grapple with the implications of Meyden's actions and the impact on the young girls involved. Michael Meyden's sentencing marks a critical step in addressing the gravity of his actions. As the families affected begin the healing process, the broader community remains united in ensuring the safety and well-being of its children. For more updates on this story and other local news, stay tuned to our website and social media channels. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on The Downfall of Diddy, The Karen Read Trial, Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, Justice for Harmony Montgomery, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, and much more! Listen at https://www.truecrimetodaypod.com

Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium (B-Free): A Multi-Centre Randomized Cluster Crossover Trial

Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery

Auf Plattformen wie TikTok sind Benzodiazepine wie Xanax in aller Munde, auch in Österreich sind die Beruhigungsmittel bei Jugendlichen beliebt. Was macht ihren Konsum so gefährlich?

Immer mehr Jugendliche in Deutschland nehmen Medikamente, obwohl sie diese medizinisch gesehen gar nicht brauchen. Medikamentensucht wird zu einem immer größeren Problem. Gemischt mit anderen Substanzen wird daraus ein gefährlicher Cocktail. Daran ist nicht nur die Pandemie schuld.Mit: Arthur Coffin, Leiter der „LogIn“-Suchtberatung in Berlin-Charlottenburg-Wilmersdorf vom Notdienst Berlin e.V.Sie haben Fragen? Schreiben Sie eine E-Mail an podcasts@ntv.de oder an Caroline Amme. Sie wollen keine Folge mehr verpassen? Dann abonnieren Sie "Wieder was gelernt" als Push-Nachricht in der ntv App oder bei RTL+ Musik, Amazon Music, Apple Podcasts, Spotify oder über den RSS-FeedSie möchten uns unterstützen? Dann bewerten Sie den Podcast gerne bei Apple Podcasts oder Spotify.Unsere allgemeinen Datenschutzrichtlinien finden Sie unter https://datenschutz.ad-alliance.de/podcast.html Alle Rabattcodes und Infos zu unseren Werbepartnern finden Sie hier: https://linktr.ee/wiederwasgelerntUnsere allgemeinen Datenschutzrichtlinien finden Sie unter https://art19.com/privacy. Die Datenschutzrichtlinien für Kalifornien sind unter https://art19.com/privacy#do-not-sell-my-info abrufbar.

Join L. Joseph Parker, a research physician, as we explore a recent comparative effectiveness study that investigates the impact of discontinuing long-term benzodiazepine therapy on patients' mortality and adverse events, especially when considering their baseline opioid exposure. Discover the key findings, implications, and the potential risks and benefits associated with benzodiazepine discontinuation in patients prescribed for stable long-term treatment. L. Joseph Parker is a research physician. He discusses the KevinMD article, "Redefining medical caution: How recent studies challenge benzodiazepine prescription norms." Our presenting sponsor is Nuance, a Microsoft company. Do you spend more time on administrative tasks like clinical documentation than you do with patients? You're not alone. Clinicians report spending up to two hours on administrative tasks for each hour of care provided. Nuance, a Microsoft company, is committed to helping clinicians restore the balance with Dragon Ambient eXperience – or DAX for short. DAX is an AI-powered, voice-enabled solution that helps physicians cut documentation time in half. DAX Copilot combines proven conversational and ambient AI with the most advanced generative AI in a mobile application that integrates directly with your existing workflows. DAX Copilot can be easily enabled within the workflow of the Dragon Medical application to bring the power of ambient technology to more clinicians faster while leveraging the proven and powerful capabilities used by over 550,000 physicians. Explore DAX Copilot today. Visit https://nuance.com/daxinaction to see a 12-minute DAX Copilot demo. Discover clinical documentation that writes itself and reclaim your work-life balance. VISIT SPONSOR → https://nuance.com/daxinaction SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended GET CME FOR THIS EPISODE → https://earnc.me/gImuWR Powered by CMEfy.

After receiving his medical degree from the Uniformed Services University of the Health Sciences in Bethesda, Maryland, Dr Sauvé completed his residency in adult psychiatry in the National Capital Consortium in Washington, DC, which includes the National Naval Medical Center in Bethesda, Walter Reed Army Medical Center in Washington, DC, and Malcolm Grow Medical Center at Andrews Air Force Base in Maryland. Shortly afterward, he was deployed to the Al Anbar Province, Iraq, as the regimental psychiatrist for the 7th Marine Regiment. After 11 years of active-duty service, he left the US Navy to become Military Clinical Director at Poplar Springs Hospital. After 3 years there, he left hospital work to dedicate his full time to Transcranial Magnetic Stimulation, a practice that has now grown to over 100 dedicated TMS centers around the country. Dr Sauvé is certified by the American Board of Psychiatry and Neurology, Inc. Dr Sauvé recently coauthored “The Science of Transcranial Magnetic Stimulation” with Laurence Crowther for the July issue of Psychiatric Annals. He is a member of the American Psychiatric Association and a Faculty Member at the Neuroscience Education Institute. You can find Dr. Sauve at https://neiglobal.libsyn.com/metabolism-mitochondria-and-mental-health-an-interview-with-dr-william-sauve-on-what-we-know-about-nutrition-and-the-brain and Twitter: @wilyliam Timestamps: 00:00 Trailer and introduction. 05:15 Listening to podcasts during long drives for education. 07:11 Transitioning to s ketamine in patient treatment. 11:51 FDA approves depression medication, including suicidal ideation. 15:21 30% of adolescents suffer mental health crisis. 19:16 Lab value 10 times higher, medical dilemma 20:20 Lab value to be double-checked, doctors disbelief. 25:43 Understanding and addressing bullying against overweight children. 27:11 Stop picking on people, but don't enable. 31:19 Fear spurs action, must treat severe depression. 36:26 Nolan Williams accelerates TMS treatment to 3 minutes. 37:41 Functional MRI guides treatment for depression efficacy. 41:53 Debate on depression diagnosis and treatment continues. 44:29 Serotonin reuptake inhibitors impact depression treatment. 49:03 Anxiety linked to dementia and Benzodiazepine use. 51:01 Dementia shows up early in some people. See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪

Brandon Daniel - Cop Killer - Full Police Interrogation Daniel, now 32, is on death row for the murder of an Austin police officer in 2012. AUSTIN – The Texas Court of Criminal Appeals has upheld the death sentence for a man convicted of fatally shooting an Austin police officer. APD Officer Jaime Padron responded to the Walmart near Interstate 35 and Parmer lane around 2:30 a.m. April 6, 2012 for a reported shoplifter. Brandon Daniel struggled with Padron before he shot and killed the officer. Daniel, now 32, was found guilty in February 2014 and sentenced to death. To whom it may concern, My name is Brandon Daniel, and I am writing this letter to you from prison. With police brutality once again in the news, and legal reform a hot topic of discussion, I'm writing to tell you about my legal case, in the hope that I might be able to spread awareness about a common but little known condition that is responsible for sending others to prison, and perhaps to leverage your platform to gain support as well. My case involves the class of anti-anxiety medication called benzodiazepines, and it is one of the clearest examples of something called Paradoxical Reaction. I am hoping that you can help me. Let me fill you in on my story. First, my background is relevant because it demonstrates that the event that led to my being here was not part of a pattern of behavior. I have no violence in my past, no felonies. I was a software engineer, I'm college educated, and I'm from a normal, middle-class home. Everything that happened that night was completely atypical and out of character. The event took place at Walmart, so it was all captured on surveillance videos. You can see me stumble around the store for twenty minutes, dropping items and running into displays. I was clearly disoriented. A police officer was called, and he confronted me, tackled me, and in the chaos of the moment I shot and killed him. The video shows how hectic the situation was, it clearly was not a thought out and intentional act. It took place in the span of 10 seconds. Subsequent blood tests revealed that I had 11 times the therapeutic dose of Xanax in my system, and these tests were taken seven hours after the event. With a half life of eleven hours, it is reasonable to assume that the amount of Xanax in my blood that night was extraordinarily high. Plus, as I later discovered, Asians metabolize Benzos faster than other populations and it stays in their systems longer. I am of Asian descent. In addition to all of this, I was interviewed by police immediately after the event, while I was still highly impaired from the medication. Again, this interview was captured on video, and one can clearly see that I am suffering from the classic symptoms of Benzodiazepines. I had amnesia, stating several times that I couldn't even remember what day or time it was. I was confabulating, giving different accounts of what happened, none of which turned out to be accurate. And I was experiencing chemical submission, complying with the detectives leading questions against my best interest. All of these are common side-effects of the Benzodiazepine class of pharmaceuticals, which includes the date rape drug “roofies.” This aspect of my case sets me apart from other similar cases, I believe. My confused statements provide a window into my state of mind at the time, while in many other incidents we can only wonder what is going on in their mind. After all of this, while awaiting trial, the jailhouse doctors put me on a cocktail of antidepressants: Zoloft, Celexa, Remeron, etc. During this time, I had several suicide attempts and I spent most of the time in observation cells, nearly catatonic. It is my belief that this common, secondary use of pharmaceuticals to medicate inmates awaiting trial, renders them complacent and fairly useless when it comes to contributing to their defense. This results in inmates who are resigned to their fate, able to be easily railroaded by the legal system, regardless of the merits of their case. Since most people who are first entering jail are, understandably, depressed, they are all too willing to accept this ‘treatment'

Welcome to the Psychedelic Conversations Podcast! Episode 106: In this episode we discuss Steven's background story, what led him to work in the psychedelic medicine space, why he specifically chooses to work with ketamine, the risks associated with the rapid discontinuation of benzodiazepines and alcohol, what ketamine is and how it is administered, Steven's ketamine protocol at Nushama, the nature of psychedelics, post-pandemic observations, forgiving but not forgetting, the importance of having meaning in our lives, never losing hope to heal depression, and much more! 00:00 - Fire Moment 01:31 - Introduction 02:56 - Steven's Background 06:46 - Why Ketamine? 07:57 - Post-Pandemic Observations 10:14 - Lost Psychedelic Research 12:04 - Benzodiazepine, Alcohol 16:11 - What Is Ketamine? 19:54 - Nushama's Protocol 24:50 - The Nature Of Psychedelics 28:55 - Infantile Perspective 33:06 - Thoughts On Bad Trips 35:45 - Multiple Modalities 39:07 - Legalizing Psychedelics 43:24 - Forgiving Yourself 47:49 - Steven's Social Media 49:13 - Having Meaning 50:05 - Last Words 52:12 - Outro About Steven: Dr. Radowitz has a wealth of experience seeing the effects trauma can have on our physical health firsthand. He joined Nushama to oversee and develop treatment modalities, believing psychedelics are the future of mental wellness as current solutions treat symptoms, not underlying issues. Dr. Radowitz also runs the primary care program at Goldman Sachs and practiced internal medicine and primary care since 1998. Originally from Montreal, he completed his M.D. at Chicago Medical School. He worked at St. Vincent's in general medicine and HIV/AIDS units and was Medical Director of the inpatient alcohol and opiate detox and treatment unit. Dr. Radowitz's focus is preventive medicine, getting to disease's source before it manifests as “dis-ease,” a misalignment of mind, body, and spirit. He believes psychedelics are a powerful tool to discover the origin of imbalance. On a spiritual journey with Kabbalah, he also studies meditation and yoga. Connect with Steven: Website: https://nushama.com/ Twitter: https://x.com/nushamawellness?s=21&t=yQZ5Nn9I3PFK-NVgLsjHjA Linkedin: https://www.linkedin.com/in/steven-radowitz-md?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app Thank you so much for joining us! Psychedelic Conversations Podcast is designed to educate, inform, and expand awareness. For more information, please head over to https://www.psychedelicconversations.com Please share with your friends or leave a review so that we can reach more people and feel free to join us in our private Facebook group to keep the conversation going. https://www.facebook.com/groups/psychedelicconversations This show is for information purposes only, and is not intended to provide mental health or medical advice. About Susan Guner: Susan is a trained somatic, trauma-informed holistic psychotherapist with a mindfulness-based approach grounded in Transpersonal Psychology that focuses on holistic perspective through introspection, insight, and empathetic self-exploration to increase self-awareness, allowing the integration of the mind, body and spirit aspects of human experience in personal growth and development. Connect with Susan: Website: https://www.psychedelicconversations.com/ Facebook: http://www.facebook.com/susan.guner LinkedIn: https://www.linkedin.com/in/susan-guner/ Instagram: http://www.instagram.com/susanguner Twitter: http://www.twitter.com/susanguner Blog: https://susanguner.medium.com/ Podcast: https://anchor.fm/susan-guner #PsychedelicConversations #SusanGuner #StevenRadowitz

Lead Story: Benzodiazepine Discontinuation and Mortality Among Patients Receiving Long-Term Benzodiazepine Therapy  JAMA Network Open In this comparative effectiveness study among 353,576 patients receiving stable long-term treatment with benzodiazepines, discontinuation was associated with small absolute increases in mortality and other potential harms, including nonfatal overdose, suicide attempt, suicidal ideation, and emergency department visits. These results suggest benzodiazepine discontinuation among patients prescribed for stable long-term treatment may be associated with unanticipated harms, and that efforts to promote discontinuation should carefully consider the potential risks of discontinuation relative to continuation. Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM

In this edition of Heard online we look at claims made about Benzodiazepine use and Alzheimer's disease. We find that symptoms of the this condition can be seen decades before a diagnosis is made, symptoms that Benzodiazepines are often prescribed for.  Would you like a roadmap from Insomnia to immunity? Download using below link. https://www.thesleepcoachschool.com/h... — Would you like to work with one of our certified sleep coach? Awesome! Here are some great options: The Insomnia Immunity Group Coaching Program.  BedTyme, a sleep coaching app for iOS and Android offering 1:1 text based coaching. - Zoom based 1:1 coaching with Coach Michelle or Coach Daniel. The Insomnia Immunity program is perfect if you like learning through video and want to join a group on your journey towards sleeping well. BedTyme is ideal if you like to learn via text and have a sleep coach in your pocket. The 1:1 Zoom based program is for you if you like to connect one on one with someone who has been where you are now. Find out more about these programs here: https://www.thesleepcoachschool.com/  Do you like learning by reading? If so, here are two books that offer breakthroughs! Tales of Courage by Daniel Erichsen https://www.amazon.com/Tales-Courage-... Set it & Forget it by Daniel Erichsen https://www.amazon.com/Set-Forget-rea...  Would you like to become a Sleep Hero by supporting the Natto movement on Patreon? If so, that's incredibly nice of you

In this episode, we welcome Dr. Josef Witt-Doerring, a board-certified psychiatrist and former FDA medical officer who has dedicated his career to helping patients safely discontinue psychiatric medications. In this information-packed deep-dive, Dr. Josef and I discuss adverse reactions during and following psychiatric medication use, especially regarding benzodiazepines and antidepressants. Dr. Josef believes that taking a more holistic approach to understanding the effects of psychiatric medication enables better therapeutic use of the drugs. He argues against the notion of merely correcting a chemical imbalance and advocates for a more fulfilling approach to psychiatry. Additionally, he suggests that family medicine doctors should refrain from prescribing these medications unless they have sufficient time to thoroughly assess the medication's impact on various aspects of a person's life. Initially, Dr. Josef pursued a career in psychiatry with the hope of combining personal development and medicine. However, upon studying and practicing psychiatry, he discovered that the field's approach to helping individuals has little to do with personal development. Instead, in Dr. Josef's view, the field often focuses on prescribing medications, likening it to a production line that simply dispenses medications, masquerading as scientific treatment for neurological deficits. He expresses disappointment in the field's lack of emphasis on personal development within psychiatry.Dr. Josef Witt-During is a board certified psychiatrist and former FDA medical officer. He specializes in adverse drug reactions of psychiatric medications and is the co-founder of Witt-During Psychiatry, along with his wife, Dr. Marissa Witt-Doerring. Together, they provide comprehensive drug taper programs, conservative medication management, and supportive coaching for those withdrawing from psychiatric drugs.For more resources related to Dr. Josef's work, please take a listen to his podcast, Life on Less Meds, his Twitter, or you can find him and others where I did, @PSSDNetwork on Twitter. This conversation builds on a previous episode where we explored mental health in the age of misinformation with Dr. Roger McFillin, which can be found here.Finally, in this episode, I mentioned a couple of great books, "Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health--and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More” by Chris Palmer which can be found on amazon or in my bookshop! Episode Topics: Post SSRI sexual dysfunction. The problem with psychiatry. Psychiatric medication and untangling. Medication and time-limited conditions. Treatment based on informed consent. Chemical imbalances and mental health. Impact of medication on relationships. Sexual dysfunction and emotional blunting. Medications and metabolic disruption. Withdrawal symptoms and support. Lifestyle interventions for withdrawal. Gluten allergy and psychosis. Quitting caffeine and its importance. Increased energy levels and relaxation. Tapering off stimulants and sedatives. Benzos prescribed for daily use. Benzodiazepine withdrawal and neurotoxicity. Benzo and antidepressant withdrawal. Oral contraceptive pill side effects. Birth control's impact on mental health. Increase in asexual and trans identities. Long-term effects of cross-sex hormones. Sexual problems in transgender individuals. Drug research and side effects. Increased suicidal ideation. Using medication for psychosis. Adverse drug reactions If you enjoyed this conversation, please rate & review it on Apple, Spotify, or wherever you get your podcasts. Share this episode with a friend, or on social media. You can also head over to my YouTube channel, subscribe, like, comment, & share there as well.To get $200 off your EightSleep Pod Pro Cover visit EightSleep.com & enter promo code SOMETHERAPIST.Take 20% off your entire purchase of nourishing superfood beverages at Organifi with code SOMETHERAPIST.Be sure to check out my shop. In addition to wellness products, you can now find my favorite books!MUSIC: Special thanks to Joey Pecoraro for our theme song, “Half Awake,” used with gratitude and permission. www.joeypecoraro.comPRODUCTION: Thanks to Eric and Amber Beels at DifMix.comYou can now watch NO WAY BACK: The Reality of Gender-Affirming Care (our medical ethics documentary, formerly known as Affirmation Generation). Stream the film or purchase a DVD. Use promo code SOMETHERAPIST to take 20% off your order. nowaybackfilm.com Follow us on Twitter @2022affirmation or on Instagram at @affirmationgeneration.Have a question for me? Looking to go deeper and discuss these ideas with other listeners? Join my Locals community! Members get to ask questions I will respond to in exclusive, members-only livestreams, plus other perks TBD.Get your first month free with promo code GRANDFATHER; after that, it's only $8/month. Check it out at somekindoftherapist.locals.com. ★ Support this podcast on Patreon ★

Welcome to part two of our series on benzodiazepines where we will be discussing the other side of benzodiazepines: the challenges of withdrawal.As healthcare providers, you are taught that benzodiazepines are in fact safe, but our host Sarah Lorenzini wants to offer a different perspective. Do we really need to be administering benzodiazepines as freely as we are taught in school? Of course for life or death situations it is a no brainer, but what about those moments when your patient is just anxious and can't calm down? Are there other ways to calm your patient down without giving them medication?These are the questions Sarah wants to explore in the second part of this series, as well as how severe benzodiazepine withdrawal can be. Sarah presents an example of a patient who was going through benzodiazepine withdrawal and how the symptoms were so severe it almost looked like the patient was experiencing a heart attack.Learn more about benzodiazepines and how you can play an important role in preventing benzodiazepine dependance.Tune in for this and more!Topics discussed in this episode:The signs and symptoms Sarah's patient was experiencingHow Sarah concluded the patient was in benzo withdrawalMild, moderate, and severe benzodiazepine withdrawal symptomsSarah's change of perspective on benzodiazepinesHow someone is weaned off of benzodiazepinesWhat to do if your patient is prescribed benzodiazepinesAlternative interventions to treat an anxious patient

In part one of the two part series on benzodiazepines, our host Sarah Lorenzini presents us with a case study about how she treated a benzodiazepine overdose during her time working as an ER Nurse. She walks us through the state her patient was in when she arrived at the hospital and the steps she took when assessing the patient and how to treat her, as well as her thought process along the way.Benzodiazepine overdoses are a little tricky. All the pieces of the puzzle matter, so having good detective skills and asking the right questions to get a full picture is crucial to treating the patient effectively, which is what Sarah wants to share in today's episode.In this episode, you will hear which questions Sarah asked in order to understand the patient's situation and medical history, as well as the critical thinking required at each step to give you a better idea of how the pieces of the puzzle are found and how they're put together. You will also hear what type of treatment works for benzodiazepine overdose and what doesn't, and much more!You don't want to miss this one!Topics discussed in this episode:The state the patient arrived to the ER and Sarah's initial assessmentQuestions Sarah asked the patient's roommateHow working in medicine requires being an investigator and counselorHow Flumazenil works and why it was not administeredA list of the signs and symptoms of a benzodiazepine overdoseTips on how to treat a benzodiazepine overdoseMentioned in this episode:Rapid Response and Rescue Intro CourseIf you would like to check out Sarah's 1hr, 1 CE course, go to: http://www.rapidresponseandrescue.com To get the FREE Rapid Response RN Assessment Guide and the coupon code for $10 off the cost of the course, message Sarah on Instagram @TheRapidResponseRN and type the word PODCAST!

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Join the Benzodiazepine Survey Research Team for a lively roundtable discussion about their research, the findings from the survey, and their latest paper which formally introduces the term benzodiazepine-induced neurological dysfunction, or BIND. Benzodiazepine use and discontinuation are associated with nervous system injury and negative life effects that continue after discontinuation, according to the article “Long-term consequences of benzodiazepine-induced neurological dysfunction: A survey” published June 29, 2023, in the open access journal PLOS ONE.The research team in attendance includes A. J. Reid Finlayson, MD, D E Foster, BA, Christy Huff, MD, Peter R. Martin, MD, MSc, and Alexis D. Ritvo, MD, MPH, along with moderator Angela Peacock, MSW.CHAPTERS00:00 Introductions (Peacock)06:02 Where It All Started (Huff)07:27 Intro to the 3rd Paper (Ritvo) 09:15 Recognizing BIND Differentiation (Foster)09:51 Is Withdrawal and BIND Different? (Martin)12:00 Limitations and Research (Finlayson)13:32 Delphic Process for Determining BIND (Ritvo) 16:23 Appropriateness of the Term BIND (Finlayson) 16:44 BIND Definition (Ritvo)17:18 Neuroadaptation & Neurotoxicity (Martin)20:40 Adverse Life Events (Ritvo) 22:22 What's Next for the Team? (Martin)24:45 What About Other Psych Drugs? (Ritvo)28:12 Any New Research Projects? (Foster) 28:44 Narrative Study of Benzo Buddies (Huff)29:22  Scoping Literature Review on Long-Term Benzo Effects (Ritvo)30:35 Overuse, Effectiveness, & Mental Health (Finlayson)32:17 Toxicity of Benzodiazepines (Martin) 34:54 Confusing for Doctors Too (Martin)36:11 Most Symptoms Are New (Martin)37:44 Large Data Analysis (Finlayson) 38:04 Any Research on Actual Neurology (Martin)38:55 Important to Narrow Down Symptoms of BIND (Finlayson) 39:17 Long Term Effects of Benzos & Other Psych Drugs (Finlayson)41:31 Neurotoxicity & Hope / People Do Heal (Foster)42:41 People Do Heal / She Is Healed (Huff)43:18 Connections with Others (Finlayson)45:16 It's Hard on Doctors Too (Martin)49:40 Marathon Not a Sprint (Ritvo)51:47 That's a Wrap (Peacock)52:22 Acknowledgments (Foster)REFERENCESNEW PUBLICATION (3rd Paper / Focus of Roundtable)— Ritvo A, Foster DE, Finlayson R, Silvernail B, Martin P. Long-term consequences of benzodiazepine-induced neurological dysfunction: A Survey. PLOS ONE. June 29, 2023. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285584. OTHER PUBLICATIONS ON THE BENZODIAZPINE SURVEY OF 2018/2019— Reid Finlayson AJ, Macoubrie J, Huff C, Foster DE, Martin PR. Experiences with benzodiazepine use, tapering, and discontinuation: an Internet survey. Therapeutic Advances in Psychopharmacology. 2022;12. doi:10.1177/20451253221082386. https://journals.sagepub.com/doi/full/10.1177/20451253221082386. — Huff C, Finlayson AJR, Foster DE, Martin PR. Enduring neurological sequelae of benzodiazepine use: an Internet survey. Therapeutic Advances in Psychopharmacology. 2023;13. doi:10.1177/20451253221145561. https://journals.sagepub.com/doi/10.1177/20451253221145561. BIND INFOMORMATION— BIND Definition (The Alliance for Benzodiazepine Best Practices) — https://benzoreform.org/BIND — Basics of BIND (Easing Anxiety) — https://easinganxiety.com/BINDBENZODIAZEPINE RESOURCES— The Alliance for Benzodiazepine Best Practices — https://benzoreform.org — Benzodiazepine Information Coalition (BIC) — https://benzoinfo.com — Easing Anxiety (The Benzo Free Podcast) — https://easinganxiety.com — The Benzodiazepine Action Work Group (BAWG) — https://benzoaction.org— A Peacock Consulting (Angela Peacock) — https://apeacockconsulting.com **************************************************************Produced by Easing Anxiety (The Benzo Free Podcast)https://easinganxiety.com **************************************************************DISCLAIMERAll content provided in this video is for general informational purposes only and should never be considered medical or health advice. The presenters in this roundtable are not engaged in rendering medical, health, psychological, or any other kind of personal or professional services. Health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it.Please visit Easing Anxiety's website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. PRODUCTION CREDITSEasing Anxiety is produced by…Denim Mountain Presshttps://www.denimmountainpress.com 

5.04 Depressants (Types, Intoxication, and Withdrawal) Psychiatry review for the USMLE Step 1 exam. Depressants decrease neuronal activity in the brain. They can work by stimulating GABAergic neurons or binding to opiate receptors. Common GABA-promoting depressants: alcohol, benzodiazepines, barbiturates, and inhalants. Opioid depressants include heroin and morphine derivatives. Alcohol enhances GABA receptor effects, inhibits glutamate activity, and causes intoxication symptoms such as disinhibition, slurred speech, impaired motor control, lethargy, respiratory depression, and coma. Alcohol withdrawal symptoms include anxiety, agitation, insomnia, nausea/vomiting, tremors, autonomic dysfunction, seizures, and can be life-threatening (delirium tremens). Benzodiazepines bind to the benzodiazepine receptor, enhance GABA effects, and cause intoxication symptoms similar to alcohol. Benzodiazepine withdrawal symptoms include anxiety, agitation, insomnia, and seizures, which are treated with a gradual tapering of the drug. Inhalants depress brain activity and cause symptoms such as disinhibition, paranoia, lethargy, dizziness, ataxia, slurred speech, and high doses can lead to respiratory depression and brain damage. Opioids bind to opioid receptors, reduce pain, improve mood, and cause intoxication symptoms like drowsiness, constricted pupils, seizures, and respiratory depression. Opioid overdose can be reversed with naloxone, an opioid receptor antagonist. Opioid withdrawal symptoms include dysphoria, anxiety, weakness, sweating, dilated pupils, and diarrhea, and can be managed with medications like methadone and buprenorphine. Alcohol withdrawal is an emergency and requires prompt treatment with benzodiazepines.

Are you using Precedex for alcohol withdrawal? Hear my take on why I don't like this idea, with evidence from a recently-published meta-analysis.Follow HERE!References:All references for Episode 94 are found on my Read by QxMD collectionSupport the showFind ER-Rx: - On Instagram: @ERRxPodcast - On the website: errxpodcast.com - On YouTube Disclaimer: The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

In this episode we chat with Michael Short, one half of the social media sketch comedy duo The Terribly Irresponsible. Michael opens about his journey down the treacherous path of prescription medicine addiction, in his own words anything with an opioid he was all over like a rash. His addiction progressed to higher quantities more frequently as he built more tolerance to the pain killers, where his whole body felt like it was immersed in a bubble bath. Michael was highly driven and motivated by the power of his addiction to seek out fulfilling his cravings in any possible way, from doctor shopping leading to being blacklisted and banned from most doctors practices, to manipulating and pulling on the heart strings of those around them to supplying his next fix. After several overdoses and some trouble with the police, Michael decided he had to make a change before he ended up in jail or dead, but was so far down the rabbit hole of addiction he needed to seek professional help and assistance in a rehab clinic to come off the pain killers, but unfortunately he was prescribed Benzodiazepine and thus led him down another chapter of addiction, taking high levels of Valium and then Xanax. Michael shares his mental health struggles, experiencing bad episodes of anxiety, depression and panic attacks, he relied on the drugs to mask the episodes he didn't want to feel, until the drugs stopped working and the anxiety got more overwhelming lead him to quit cold turkey and suffer and struggle a long 9 month process of withdrawal where he thought he wouldn't make it out alive. Michael's story is an emotional one, confronting his past mistakes learning who he is without the drugs and wanting to make up for it through positive outlets and finding passion in creating gags on social media. We thank Michael for sharing his story, and commend his courage to be so open about his turbulent past. Thank you Zekr Skin for sponsoring this video. Get 25% off all Zekr Skin products using code: LASTDRINKS25 ⁠⁠⁠https://zekrskin.com⁠⁠⁠ DONATE TO THE PODCAST:⁠⁠⁠ https://www.buymeacoffee.com/lastdrinks⁠⁠ The Terribly Irresponsible Links: Instagram: ⁠https://www.instagram.com/theterriblyirresponsible/ TikTok: https://www.tiktok.com/@theterriblyirresponsible Facebook: https://www.facebook.com/theterriblyirresponsible YouTube: ⁠⁠⁠⁠https://www.youtube.com/@TheTerriblyIrresponsible LAST DRINKS PODCAST LINKS: Instagram: ⁠⁠⁠https://www.instagram.com/lastdrinkspodcast⁠⁠⁠ Tik Tok: ⁠⁠⁠https://www.tiktok.com/@lastdrinkspodcast⁠⁠⁠ YouTube: ⁠⁠⁠https://www.youtube.com/@lastdrinkspodcast

BREAKING NEWS: The 2022 CDC Opioid Guideline Update is published!!!   Unless you'd like to read all 100 pages of the guideline publication on your own, you may want to start by listening to this episode at least once.   Join the Mark “Pain Guy” Garofoli on the Pain Pod for a dynamic dissection of the 2022 CDC Opioid Guideline Update. Not a ton of actual updates compared to the 2016 guideline, but a half dozen that every clinician needs to be aware of, along with a handful a very specific reference checks leading to rather riveting conversations in the near future for you. “Pain Guy” will review all aspects of this incredibly important advancement in pain management so that you can correlate to your own patient care, educational efforts, or whatever setting you're in NOW.   You may want to listen to this episode twice, and share it will everyone (seriously, all clinicians need to listen in, and patients in pain alike)!!!   Come one, come all, to the Pain Pod!!!   2022 CDC Opioid Guideline Revision Resources 2022 CDC Opioid Guideline Update: CDC Chronic Pain Opioid Guidelines: MMWR March 2016. http://dx.doi.org/10.15585/mmwr.rr7103a1 CDC Opioid Guideline Update Timeline: https://www.cdc.gov/opioids/guideline-update/index.html CDC Drug Overdose Deaths Data (Including Prescription Opioids): https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm Initial Rx Opioid Duration compared to Probability of Continued Use: Shah A, et al. Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use — United States, 2006–2015. MMWR Morb Mortal Wkly Rep 2017; 66: 265–269. Opioid and Benzo Combination tripling overdose death rate: Tae Woo Park, et al. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ 2015;350:h2698. 2016 CDC Chronic Pain Opioid Guideline: https://www.cdc.gov/mmwr/volumes/65/rr/rr6501e1.htm

Benzodiazepine's are ineffective and overprescribed for radicular low back pain. On this episode we highlight a new study showcasing how chiropractic care, and spinal manipulative therapy, can lead to a dramatic reduction in benzodiazepine prescriptions.Episode Notes:Association between chiropractic spinal manipulative therapy and benzodiazepine prescription in radicular low back pain: a retrospective cohort study protocol using national real-world dataDesigned by a Podiatrist over 30 years ago after seeing similarities in many of the custom devices he was creating, PowerStep offers an affordable, same day solution that combines support and cushioning. Want to try a pair for yourself, click here for a free sample pair.The Smart Chiropractor powers your patient journey to provide you with more qualified leads, more new patients, better patient retention, and consistent reactivations, without any money spent on advertising.ChiroMatchMakers specializes in DC and CA hiring. We have over 100 positions available right now with salaries starting at $85K. Discover the available positions today by clicking here. Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!