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Marshall Green of Giants Now By Chat Sports is on the show to talk about the Giants first week of free agency, Evan Neal returning, the newest Free agents, and the Giants signing WR Calvin Austin from the Steelers Follow Marshall here:https://x.com/MarshallGreen_?s=20 https://www.youtube.com/@NYGiantsTV Download the Fanatics Sportsbook app , use code JOMBOY https://fanatics.onelink.me/5kut/JOMBOY New customers who sign up and Bet $5, Get $100 in FanCash*. Use FanCash on bonus bets, profit boosts, team gear and more on Fanatics.com. *New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MO, NC, NJ, NY, OH, PA, TN, VA, VT, WV, or WY. Must toggle on this promotion in your bet slip and wager $5+ cash on any market (min. odds -500) within 7 days of account opening to receive $100 in FanCash. Promotional FanCash expires 7 days from issuance (at 11:59pm ET). Terms, including FanCash terms apply-see Fanatics Sportsbook app. Use FanCash on bonus bets, profit boosts, team gear on Fanatics.com and so much more. 00:00 Giants Sign Calvin Austin + Marshall Green Talks Free Agency 01:30 Giants Sign WR Calvin Austin 07:00 How can the offense use Austin 13:30 Giants Now by chat sports joins the show 14:10 Evan Neal is back 17:30 Giants want a heavier OL 20:15 The Giants needed to be more aggressive in Free Agency 26:10 Expectations for Isaiah Likely 19:47 Likely will help Jaxson Dart create big plays 33:30 Playing in the slot 36:50 Ricard will highlight the running game 41:00 Drafting a WR 45:55 Need another LB with Edmunds 51:00 Worried about the CB room 56:55 Need Adebo to play like a CB1 01:00:11 Taking special teams seriously 01:03:15 Run defense is still bad Check out our Merch: https://shop.jomboymedia.com/collections/talkin-giants Subscribe to JM Football for our NFL coverage: https://www.youtube.com/@JMFootball Follow all of our content on https://jomboymedia.com #giants #nygiants Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Mock Draft Monday takes a whole new angle this week as we dig into the athletic benchmarks and physical profiles the Packers have historically favored at every position — then build an entire mock draft around them. Using combine data going back to 2018, we compare Green Bay's draft tendencies against NFL averages to find the prospects who truly fit the Packers' DNA. Deep dive into Packers combine benchmarks vs. NFL averages at every position — what actually separates Green Bay's picks from the rest of the league? A stunning revelation: the Packers have invested just ONE draft pick at cornerback in rounds 1-4 since 2018 (Eric Stokes), making CB1 an urgent need Full mock draft featuring Chris Johnson (CB, San Diego State), small-school riser Caleb Proctor (DT, SE Louisiana), Alabama center Parker Brailsford, and more Late-round gems explored including Mason Rieger's Shrine Bowl explosion, Joe Fagnano's breakout season at UConn, and Khalil Dinkins' untapped tight end potential Whether you're a draft junkie or just want to understand how Green Bay builds its roster, this one's packed with data, film notes, and fresh names for your draft board. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Website: https://nfldraftgrades.com/ My Board: https://nfldraftgrades.com/board/83a18c42-7a0b-4590-8d1b-453e49840d02
Mock Draft Monday takes a whole new angle this week as we dig into the athletic benchmarks and physical profiles the Packers have historically favored at every position — then build an entire mock draft around them. Using combine data going back to 2018, we compare Green Bay's draft tendencies against NFL averages to find the prospects who truly fit the Packers' DNA. Deep dive into Packers combine benchmarks vs. NFL averages at every position — what actually separates Green Bay's picks from the rest of the league? A stunning revelation: the Packers have invested just ONE draft pick at cornerback in rounds 1-4 since 2018 (Eric Stokes), making CB1 an urgent need Full mock draft featuring Chris Johnson (CB, San Diego State), small-school riser Caleb Proctor (DT, SE Louisiana), Alabama center Parker Brailsford, and more Late-round gems explored including Mason Rieger's Shrine Bowl explosion, Joe Fagnano's breakout season at UConn, and Khalil Dinkins' untapped tight end potential Whether you're a draft junkie or just want to understand how Green Bay builds its roster, this one's packed with data, film notes, and fresh names for your draft board. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Website: https://nfldraftgrades.com/ My Board: https://nfldraftgrades.com/board/83a18c42-7a0b-4590-8d1b-453e49840d02
Rams LAFB Show | Ryan Anderson w/ Cody Alexander (Match Quarters) On this episode of the Rams LAFB Show, Ryan Anderson is joined by defensive guru Cody Alexander of the Match Quarters Substack and Let's Talk Ball podcast to break down where the Rams stand after coming up just short of the Super Bowl — and what needs to change in 2026. What we cover: ️ Why the Rams' defense stalled late — and how pass-rush depth (not just stars) is the real issue Chris Shula's scheme, blitz rates, and why the front & backend stopped complementing each other Cornerback problems: Do the Rams need a true CB1, a nickel, or just more bodies? Ranking the Rams' young defensive linemen (Verse, Turner, Young, Fisk) and who's worth paying ️ What the Rams can learn from Super Bowl defenses that win with four up front Kliff Kingsbury to the Rams: what he actually brings beyond the “Air Raid” label How Kingsbury + Nate Scheelhaase could evolve McVay's offense and prep for life after Stafford The Rams' long-term QB plan — draft, develop, or wait for the next big opportunity? If you love real Xs & Os, smart roster-building talk, and zero hot-take fluff, this episode is for you. Check out Cody's work: Match Quarters Substack Let's Talk Ball podcast Like, subscribe, and let us know in the comments: What should the Rams fix first — cornerback or pass-rush depth? Use promo code RAMSLAFB on Sleeper and get 100% match up to $100! https://Sleeper.com/promo/RAMSLAFB. Terms and conditions apply. #Sleeper Become an LAFB Lifer and get special perks by joining our Exclusive Los Angeles Rams Community: https://www.lafbnetwork.com/plans/join/ Check out our FREE Rams Message Board: https://www.lafbnetwork.com/forums/forum/los-angeles-rams/ Listen to our Rams Podcast: https://podcasts.apple.com/us/podcast/the-rams-skinny-a-los-angeles-rams-podcast/id1707103542 Check Out Our Rams LAFB Merch: https://lafbnetwork.myshopify.com/ Go to www.LAFBNetwork.com for FREE full access to all of our podcasts and join the community! Social Media: @LAFBNetwork | @RyanDyrudLAFB | @RLAndersonLAFB Sponsors: Sean McVay is the Los Angeles Rams' Football Head Coach as the team heads into the 2025 NFL Season, looking to build upon their playoff divisional appearance from one year ago. Matthew Stafford is back at quarterback, and he will lead the Rams throughout the season with Puka Nacua, Davante Adams, and Kyren Williams. Jared Verse and Braden Fiske will look to build upon stellar rookie campaigns on defense for the Rams. Make sure to subscribe to the Rams LAFB YouTube Channel and head to https://www.lafbnetwork.com for all of your Los Angeles Rams content needs! #rams #nfl #nflshorts #ramshouse #all22 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the December 2025 Emergency Medicine Practice article, Diagnosis and Management of Cannabis-Related EmergenciesEpisode Outline: [0:00] IntroductionWelcome and show overview by Sam AshooMention of resources at ebmedicine.net[0:46] Episode StartHosts introduce themselves: Sam Ashoo and Dr. T.R. EcklerDr. Eckler's background and experience with cannabis cases in Colorado[1:16] Topic IntroductionFocus on diagnosis and management of cannabis-related emergenciesPrevalence and importance in emergency medicine[1:34] Legal LandscapeOverview of cannabis legality across statesMedicinal vs. non-medicinal use[3:03] Increase in ED VisitsStatistics: ~1 million cannabis-related ED visits annuallyDemographics: younger population most affected[3:52] Synthetics and ChallengesDiscussion of synthetic cannabinoids and their risksIssues with detection and legality[4:50] Clinical SpectrumRange of presentations: from nausea/vomiting to psychosis and seizuresImpact on different age groups[6:34] FDA-Approved UsesCannabis-derived products approved for specific medical conditions[7:20] Physiology and PathophysiologyCannabinoid receptors (CB1 and CB2) and their effectsDifferences between plant-derived and synthetic cannabinoids[9:10] Chronic Use and WithdrawalDownregulation of receptors, withdrawal symptoms, and persistent nausea[10:20] Product Forms and Delivery MethodsSmoking, edibles, oils, tinctures, suppositories, topicals, etc.Risks associated with concentrated forms (e.g., wax, oils)[12:00] Clinical Effects by SystemPsychiatric: anxiety, psychosis, paranoiaCardiovascular: tachycardia, MI risk, QT prolongationPulmonary, renal, metabolic, dental, and ocular effects[13:50] Cannabinoid Hyperemesis Syndrome (CHS)Phases: prodrome, hyperemesis, recoveryHot showers as a diagnostic clue[16:00] Withdrawal SyndromeSymptoms and timelineExacerbation with synthetic cannabinoids[18:15] Counseling and ManagementImportance of cessation and patient educationTimeline for symptom improvement[18:42] Differential DiagnosisBroad differential for persistent nausea/vomiting and abdominal painImportance of considering other causes[20:55] Diagnostics and TestingLimitations of drug screens (false positives/negatives)Importance of EKG, labs, and imaging as indicated[23:10] Treatment ApproachesFirst-line: benzodiazepines, antiemetics (ondansetron, metoclopramide)Second-line: butyrophenones (haloperidol, droperidol), olanzapineCapsaicin as adjunct therapy[29:50] Complications and Special ConsiderationsRisks of undertreatment (e.g., Boerhaave syndrome, aspiration)Pediatric and pregnant populations: unique risks and reporting requirements[36:00] Five Practice-Changing TakeawaysElicit cannabis use historyKnow testing limitationsConsider ECG and appropriate labsUse butyrophenones when indicatedAdmit if symptoms are refractory[39:00] ConclusionEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net
Where are you listening from?Your kitchen might be the best dispensary you'll ever have, but the real magic happens in your brain. We pull back the curtain on the endocannabinoid system and show how edibles—especially THC—bind to CB1 receptors, ripple through dopamine, GABA, and serotonin, and shape everything from euphoria to anxiety to time distortion. If you've noticed that your favorite gummy doesn't hit like it used to, there's a reason: tolerance builds as your brain downregulates receptors. The good news is that sensitivity can return faster than you think with a short, intentional break.Ready to reset your relationship with cannabis? We're launching the Fresh Start Tolerance Break Challenge for January—daily check-ins, weekly videos, science-backed tips, and a supportive community to help you rebuild sensitivity, save money, and return with intention. Whether you're new to edibles or a seasoned home cook crafting your own infusions, this guide gives you the science and structure to make every dose count.Join the Challenge, share this episode with a curious friend, and leave a review to help others find the show.Join the waitlist at JoinBiteMe.com/challenge - Music by Alexander BluSupport the show Visit the website for full show notes, free dosing calculator, recipes and more.
CB1 inhibition is an approach that taps into the body's natural metabolism to burn fat while preserving muscle for more sustainable weight loss. Unlike GLP-1s, which suppress appetite, CB1 inhibition activates fat-burning processes. In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with Punit Dhillon, CEO of Skye Bioscience, for a conversation on CB1 inhibitor antibodies in the obesity space. Dhillon discusses GLP-1 weight-loss drugs like semaglutide having taken the world by storm, despite the concerns over side effects, as well as what CB1s could mean for the obesity and weight-loss field. You can listen to episode 227 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
The Boston Herald's Andrew Callahan and BSJ's Mike Giardi dive into whether Christian Gonzalez is actually having a down year. The guys look at his coverage numbers, how the Patriots are using him, and whether the expectations around a true CB1 are skewing the conversation. Patriots on CLNS Media is Powered by:
Hour 1 of The Drive kicks off with Zach and Phil cross talking with Dover and Cecil. The guys discuss the NFL and how there are no great teams in the AFC. Do the Broncos need to go out and make a trade before the trade deadline to add to their offense? Zach and Phil go in depth into Bo Nix's numbers when it comes to getting blitzed. How has Nix improved after seeing so many different defensive looks and blitzes over the past season and a half? The guys debate how impactful the injury to Patrick Surtain will be for the Broncos. Are Riley Moss and Kris Abrams-Draine up for the challenge of being CB1 and CB2? Zach shares the stats on how dominant this Nuggets team has been offensively and how hot of a start Jamal Murray is off to.
In hour 3 of The Drive, Zach and Phil are joined by veteran NFL reporter James Palmer to discuss how the Broncos were able to impact the Cowboys' great offense, the concern level with Patrick Surtain potentially missing time, and Sean Payton's faith in the young Broncos including Harvey and Franklin. Should the Broncos be "buyers" at the NFL trade deadline to add an offensive piece? Where are Zach and Phil with Bo Nix after he had arguably his best game as a Broncos this past weekend? The guys debate how impactful the injury to Patrick Surtain will be for the Broncos. Are Riley Moss and Kris Abrams-Draine up for the challenge of being CB1 and CB2? Zach shares the stats on how dominant this Nuggets team has been offensively and how hot of a start Jamal Murray is off to.
Starting today, all Coinbase One US subscribers will have early access to Coinbase Research. If you're a CB1 subscriber, check your inbox now. In this episode, we cover some of the topics from our latest Monthly Outlook. We also wade into the enterprise L1 debate following the announcement that long-time Ethereum Foundation researcher Dankrad Feist is joining Tempo — a new L1 focused on payments and stablecoins. We also walk through the latest Charting Crypto report where we unpack new investor survey signals, dig into our Global M2 Money Supply Index, and discuss the role of digital asset treasuries as a force for structural demand across BTC and ETH.Speakers:David Duong, CFA - Global Head of Investment ResearchBen Rodriguez - Senior Protocol SpecialistColin Basco - Research Associate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
In this mind-expanding episode, Darin sits down with Dani Fontaine — researcher, practitioner, and expert on the human body's forgotten communication system: the endocannabinoid system. They unravel how this network regulates everything from mood and sleep to pain and consciousness — and why it was deliberately scrubbed from mainstream medical education. Dani reveals how cannabinoids, light, sound, and nature all communicate with our body's receptor fields — shaping the way we feel, heal, and perceive the world. Together they explore the profound spiritual and scientific implications of this hidden system, and how it connects us back to balance, nature, and truth. What You'll Learn 00:00:00 - Welcome to the SuperLife Podcast 00:00:32 - Sponsor: Energy Bits 00:01:52 - Introducing Guest Danny Fontaine: Cannabis Pioneer and Plant Medicine Healer 00:04:54 - Deep Dive: What is the Endocannabinoid System (ECS)? 00:06:30 - ECS: The Homeostasis and Retrograde Signaling System 00:09:20 - ECS as a Receptive System for Subtle Energies and Environment 00:10:23 - Endocannabinoid System Toning (X-Tone) 00:12:58 - When the ECS Gets Worn and Depleted 00:16:34 - ECS Receptors on Every Cell, Fascia, and Neural Makeup 00:19:14 - How the ECS Breaks Down: The Impact of False Light 00:22:11 - The ECS and Non-Photon Rich Food 00:23:40 - Modulating the ECS Through the Six Senses (Touch and Breath) 00:24:38 - Mitochondria and ECS Receptors (MTK, CB1) 00:25:14 - Endogenous ECS and the Need for Proper Nutrients 00:27:11 - Cannabis as our Phyto Twin: The Plant Factor 00:27:57 - THC and the Suppression of Anandamide (Bliss Molecule) 00:31:44 - Sponsor: Fatty 15 00:35:25 - The Vast Amount of ECS Research & Medical Suppression 00:38:27 - Cannabinoids, Pain, and Individual Assessment 00:40:29 - Modulating ECS with Nature: Terpenes like Pinene 00:42:51 - Olfactory System as the Most Sophisticated Input 00:47:03 - ECS as the "Microscope Moment" for Health 00:48:23 - Pinene, CB1, and TRP Receptors in Pain Management 00:50:39 - The ECS, Collagen, and Hyaluronic Acid Fluctuation 00:51:44 - Working with the ECS for Faster Results (Cancer and Genetic Mutations) 00:55:06 - Sponsor: SuperLife Patreon 00:56:39 - Measuring the ECS with Bio-Field Technology 00:57:29 - The Danger of THC Stacking and Immunosuppression 00:59:30 - Overwhelmed Cells and Fake Inputs 01:00:12 - Hemp as a Homeostasis Plant for the Planet (Soil Remediation/Carbon) 01:02:06 - ECS Strength in Animals vs. Humans 01:04:08 - Why Cannabis and Hemp Were Suppressed 01:07:07 - The Historical Use of Cannabis in Medicine 01:08:12 - Hemp's Nutritional Profile (Amino Acids and Omegas) 01:09:37 - Ayahuasca, Receptor Overexpression, and Looping 01:13:33 - Importance of ECS Knowledge and Application 01:14:58 - Exercise, Anandamide, and ECS Toning 01:15:22 - Cold Plunge and Shocking the ECS and Hormones 01:17:16 - Takeaways: Light, Movement, Sound, and Breath 01:21:41 - ECS: The Main Signaling and Communication System 01:23:28 - Final Thoughts: ECS as the Conduit to Self and Spirit Thank You to Our Sponsors: Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. EnergyBits: Get 20% off your entire order by going to https://energybits.com/ and using code DARIN at checkout. Find More from Dani Fontaine Instagram: @danifontaine Website: danifontaine.com Products: Try Dani's Nature Root Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com Key Takeaway “Your endocannabinoid system isn't just a biology lesson — it's a bridge between your body and the universe. When you feed it light, breath, and truth, you remember what balance actually feels like.”
Packers fans, buckle up for another raw, unfiltered dive into the highs and lows of being a Green Bay diehard. In this episode, callers vent about the lackluster win over the Bengals, questioning why victories feel like letdowns amid injuries to stars like Jayden Reed and Christian Watson. We explore the eternal fan pessimism and whether switching allegiances to teams like the Lions or Chiefs would really fix anything. Breaking down fan negativity: Why can't we celebrate wins without nitpicking every flaw? Hilarious analogies: From hot wives in sweatpants to Patriots' "trash" Super Bowl runs despite losses. Hot debates: Is Keyshawn Nixon a legit CB1? Plus, calling out schemes that supposedly "hold back" WR1s like in fantasy football glory days. Injury frustrations and team envy: Callers ponder ideal squads and why Packers' issues aren't unique. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. If you're loving the late-night vibes, smash that subscribe button, drop a rating, and hit us up on social with your takes. Catch you next time for more Packers chaos - stay edgy! #PackersAfterDark #GoPackGo #NFLDrama To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
Packers fans, buckle up for another raw, unfiltered dive into the highs and lows of being a Green Bay diehard. In this episode, callers vent about the lackluster win over the Bengals, questioning why victories feel like letdowns amid injuries to stars like Jayden Reed and Christian Watson. We explore the eternal fan pessimism and whether switching allegiances to teams like the Lions or Chiefs would really fix anything. Breaking down fan negativity: Why can't we celebrate wins without nitpicking every flaw? Hilarious analogies: From hot wives in sweatpants to Patriots' "trash" Super Bowl runs despite losses. Hot debates: Is Keyshawn Nixon a legit CB1? Plus, calling out schemes that supposedly "hold back" WR1s like in fantasy football glory days. Injury frustrations and team envy: Callers ponder ideal squads and why Packers' issues aren't unique. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. If you're loving the late-night vibes, smash that subscribe button, drop a rating, and hit us up on social with your takes. Catch you next time for more Packers chaos - stay edgy! #PackersAfterDark #GoPackGo #NFLDrama To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
The Chicago Bears face a crucial matchup against the Washington Commanders on Monday Night Football. Can Caleb Williams build on his improved pass protection and lead the Bears to victory? The defense must contain the Commanders' potent run game, with TJ Edwards and Kyler Gordon returning to bolster the unit. Tyrique Stevenson steps into the CB1 role, aiming to shut down Jaden Daniels. Rome Odunze looks to continue his hot streak as Williams' favorite target. With both teams battling injuries, this game presents a prime opportunity for the Bears to gain momentum. Will Chicago's offensive line create holes for the struggling run game? Tune in to see if the Bears can secure their third straight win and climb back into playoff contention.Podcast Links: https://linktr.ee/ChiBearsCentralGet at us:Email: ChicagoBearsCentral@gmail.comTwitter:@ChiBearsCentralPhone: (773) 242-9336Our Sponsors:* Check out Cigars International and use my code BEARSCENTRAL for a great deal: https://www.cigarsinternational.comAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.A new survey from CRB shows that most life sciences companies, particularly smaller biotechs, are not planning new investments in response to tariffs. The majority of manufacturing initiatives in the U.S. made in response to tariffs are coming from big pharma companies. Sky Bioscience's CB1 inhibitor, Nimacimab, showed promising weight-loss results when combined with Wegovy despite falling short of expectations in a mid-stage obesity trial. Amgen will offer its lipid-lowering drug Repatha directly to patients at a 60% discount. Biospace has honored 40 under 40 leaders in biopharma whose achievements reflect the industry's grit and impact. Pfizer beat out two other suitors for a takeover of Metsera. Maplight seeks a $227 million IPO for its neuropsych portfolio.AMT designation is taking its first steps amid uncertain benefits. Pharming's restructuring triggers a 20% reduction in its workforce. Experts are forging new paths to address scalability, cost, and other barriers surrounding cell therapy production.The CDC has adopted ACIP recommendations on chickenpox and COVID-19 vaccines. Stay tuned for upcoming events such as webinars on mRNA medicine, biopharma deregulation, and transforming digital sequences into mRNA.Various job opportunities in the life sciences industry include positions at Sonothera, Eli Lilly and Company, and Amgen.Support the show
Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Systematic Review Findings: Cochrane umbrella review of 9 systematic reviews (51 trials; n=2,895) comparing active TENS with sham/usual care found uncertain efficacy due to: Very low-quality evidence (risk of bias, small samples, methodological limitations). Inconsistent adverse event reporting. Heterogeneity in TENS parameters and comparators. Authors note uncertainty may be confounded by inadequate dosing not being an inclusion metric. Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter. David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care. As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923. Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp
Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter. David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care. As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923. Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp
Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter. David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care. As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923. Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp
On this week's edition of the Tapping The Keg podcast, Charlie & Mitch talk about the Green Bay Packers, Milwaukee Brewers, and the Wisconsin Badgers. Charlie and Mitch talk about Packers island. Which players and takes are we buying property on their 'islands'? Which ones are we selling? We discuss the Packers being the best team in the NFL, Keisean Nixon as CB1, Matthew Golden and muchore. The boys move on to discuss what the Milwaukee Brewers will look like in the next two weeks. Lastly, Charlie and Mitch talk about if the Wisconsin Badgers football job is still one of the best in the Big Ten.
Send us a textThe New York Giants' defense is under the spotlight in this episode of 2 Giants Goofballs as Drew and Rob deliver their 53-man roster predictions and react to major news about left tackle Andrew Thomas, who has officially passed his physical and is eligible to return. While Thomas is unlikely to suit up against the Patriots this Thursday, his presence off the PUP list is huge for the Giants' season outlook.We break down the entire defensive depth chart: Dexter Lawrence continuing to anchor the line, Roy Robertson-Harris and Rakeem Nunez-Roches providing veteran stability, and rookies like Darius Alexander and Elijah Chatman fighting to prove themselves. On the edge, the combination of Brian Burns and Kayvon Thibodeaux headlines a dangerous pass-rush group that also includes Abdul Carter and Chauncey Golston. At linebacker, Bobby Okereke and Micah McFadden remain the core, with Darius Muasau flashing potential alongside veterans Chris Board and Demetrius Flannigan-Fowles.The cornerback competition is one of the hottest battles of camp, with Deonte Banks trying to lock down CB1 duties while Cor'Dale Flott pushes for reps. Add in Paulson Adebo, Dru Phillips, Tre Hawkins, and Nic Jones, and this secondary is deeper than in years past. Safety also looks strong, led by Jevon Holland, rookie Tyler Nubin, Dane Belton, and K'Von Wallace. Special teams return intact with Graham Gano at kicker, Jamie Gillan at punter, and Casey Kreiter at long snapper.We'll also preview the Giants vs. Patriots preseason matchup, which the hosts will be attending. Expect insights on who needs to step up, what battles could be decided Thursday night, and how the Giants are preparing to finalize the roster.Thank you for watching & for your support. You made it to the bottom of the description so you must like the show!Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballsSubscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1Become a Member of the YouTube Goofball Channel for Perkshttps://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/joinFollow us On Facebookhttps://www.facebook.com/2giantgoofballsFollow us On Xhttps://x.com/2giantgoofballsPrefer Audio Only? Check Out Those Options Herehttps://2giantgoofballs.buzzsprout.com/Support the showThank you for watching & for your support. You made it to the bottom of the description so you must like the show! Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/ Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballs Subscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1 Become a Member of the YouTube Goofball Channel for Perks https://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/join Follow us On Facebookhttps://www.facebook.com/2giantgoofballs Follow us On Xhttps://x.com/2giantgoofballs
Send us a textThe New York Giants face the most critical stretch of the preseason as the 53-man roster deadline approaches, and the tough decisions are about to unfold. Drew and Rob are here live to break it all down for the Goofball Army. The quarterback situation is drawing headlines as rookie Jaxson Dart continues to push for the No. 2 job behind Russell Wilson, leaving Jameis Winston and Tommy DeVito in danger. At running back, Eric Gray is battling to keep his spot while Cam Skattebo and Dante “Turbo” Miller are showing flashes that could change the depth chart. Wide receiver has become a bloodbath with Lil'Jordan Humphrey, Beaux Collins, and Montrell Washington fighting for the final roster spots.The offensive line picture isn't any clearer. Evan Neal's move inside is creating a battle with Greg Van Roten at right guard, and the Giants must decide if James Hudson can hold down a starting job or if Marcus Mbow is ready to take over. On defense, Deonte Banks' inconsistency has left the CB1 job in question as Cor'Dale Flott continues to push him. Meanwhile, Elijah Chatman is getting looks at fullback, and while creative, the experiment raises the question of whether his defensive snaps are too valuable to risk.Brian Daboll has praised Jaxson Dart's command, toughness, and leadership, but even glowing reviews won't save everyone on this roster. Abdul Carter added fuel to the fire with his fiery comments about the Jets, showing both his confidence and his edge as a rookie. Every position group has players on the bubble, and the Giants' front office must balance loyalty to veterans with the upside of hungry young players.Thank you for watching & for your support. You made it to the bottom of the description so you must like the show!Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballsSubscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1Become a Member of the YouTube Goofball Channel for Perkshttps://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/joinFollow us On Facebookhttps://www.facebook.com/2giantgoofballsFollow us On Xhttps://x.com/2giantgoofballsPrefer Audio Only? Check Out Those Options Herehttps://2giantgoofballs.buzzsprout.com/#nygiants #giants #newyorkgiants #gmen #53manrosterSupport the showThank you for watching & for your support. You made it to the bottom of the description so you must like the show! Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/ Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballs Subscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1 Become a Member of the YouTube Goofball Channel for Perks https://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/join Follow us On Facebookhttps://www.facebook.com/2giantgoofballs Follow us On Xhttps://x.com/2giantgoofballs
Storm Duck has established himself as CB1 of the Miami Dolphins, but the rest of the CB room is up for grabs. Ollie Gordon gains momentum in the battle for RB2. Hollywood's Headlines includes a fake Micah Parsons quote, a fight at the Jags/Saints game, and Hassan Whiteside's house is for sale.
Send us a textWhat is the core evolved function of the endocannabinoid system?Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system.About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core components like CB1 receptors and lipid-based molecules derived from omega-6 fatty acids; its cellular signaling, evolutionary role in energy storage for uncertain futures (exostasis vs. homeostasis); effects across tissues; motivation, appetite, pain relief, and anxiety regulation; biphasic effects of cannabinoids.Discussion Points:The endocannabinoid system acts as an "exostatic" regulator, promoting energy accumulation for future needs by enhancing food palatability, nutrient absorption, and fat storage, unlike "endostatic" systems that address immediate hunger.CB1 receptors appear in vertebrates with adipose tissue, suggesting an evolutionary link to storing fat for survival in unstable environments.Endocannabinoids are lipids from omega-6 fats; high intake boosts their levels, potentially fueling obesity by creating a self-perpetuating cycle of overeating.Activation of CB1 can have biphasic effects due to receptors on different cell types like excitatory vs. inhibitory neurons.Pregnenolone, a steroid precursor, acts as a natural CB1 inhibitor to prevent excessive activation, blocking harmful effects like psychosis from high THC doses.The system influences motivation beyond food, including sex and even human activities like sports or storytelling, by rewarding actions for potential future benefits.In the brain, CB1 on mitochondria and astrocytes modulates energy use, olfaction, and social stress transmission, with implications for disorders like Alzheimer's.Reference Paper:CB1 Receptor as the Cornerstone of ExostasisRelated episode:M&M 123: EndocanSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts
Richard Sherman goes inside San Francisco 49ers camp for exclusive, unfiltered conversations with George Kittle, Brock Purdy, Deommodore Lenoir, and head coach Kyle Shanahan. From locker room leadership and personal growth to Super Bowl expectations, it's a rare look at the mindset behind one of the NFL’s elite teams. 02:00 – George Kittle on training camp, leadership, and playoff memories.17:00 – Brock Purdy on fatherhood, Kyle Shanahan, and proving himself.33:40 – Deommodore Lenoir on becoming CB1 and leading the secondary.42:40 – Kyle Shanahan on roster rebuilding, QB development, and 2025 expectations. #VolumeSee omnystudio.com/listener for privacy information.
The Green Bay Packers had another eventful practice at Ray Nitschke Field, where second-year linebacker Edgerrin Cooper reminded everyone that he's really good. Meanwhile, cornerback Keisean Nixon continued his standout play this summer as "CB1." Wide receiver Romeo Doubs stayed hot, catching a touchdown in the RedZone Period ... but the day was dominated by Jeff Hafley's defense. (Which has become a theme this summer...) Oh, and the Milwaukee Brewers remain the hottest team in baseball. Vinny Rottino from FanDuel Sports Network joins the show to discuss.See omnystudio.com/listener for privacy information.
In today's episode of the Packernet Podcast, host Ryan Schlipp dives headfirst into the growing wave of criticism surrounding the Packers' defense. Using a recent viral exchange between a beat writer and a fan as a jumping-off point, Ryan dismantles some of the more extreme claims—like Keyshawn Nixon being CB1 as a problem, Rashan Gary being overpaid, and Caleb Williams “dog walking” the Packers defense. Ryan walks listeners through the data, challenges faulty narratives, and even gets a bit philosophical about the culture of constant negativity in the fanbase. Plus, shoutouts to Malik Turner for his big UFL moment and Christian Watson for the growing family! If you're looking for a no-nonsense, stats-driven defense of the Green Bay Packers, this one's for you. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
In today's episode of the Packernet Podcast, host Ryan Schlipp dives headfirst into the growing wave of criticism surrounding the Packers' defense. Using a recent viral exchange between a beat writer and a fan as a jumping-off point, Ryan dismantles some of the more extreme claims—like Keyshawn Nixon being CB1 as a problem, Rashan Gary being overpaid, and Caleb Williams “dog walking” the Packers defense. Ryan walks listeners through the data, challenges faulty narratives, and even gets a bit philosophical about the culture of constant negativity in the fanbase. Plus, shoutouts to Malik Turner for his big UFL moment and Christian Watson for the growing family! If you're looking for a no-nonsense, stats-driven defense of the Green Bay Packers, this one's for you. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
The Los Angeles Rams acquired former first-round pick Emmanuel Forbes during the season last year. With a full offseason with the team, both head coach Sean McVay and defensive coordinator Chris Shula have spoken very highly of the former Washington Commander.Does he have a real opportunity to become a starting piece, and even the team's CB1?Tune in and subscribe to the Rams LAFB YouTube Channel!Listen to our Rams Podcast: https://www.lafbnetwork.com/nfl/la-rams/la-rams-podcast/Go to www.LAFBNetwork.com for FREE full access to all of our podcasts and join the community!Social Media: @LAFBNetwork | @RyanDyrudLAFB | @RLAndersonLAFBSean McVay is the Los Angeles Rams' Football Head Coach as the team heads into the 2025 NFL Season, looking to build upon their playoff divisional appearance from one year ago. Matthew Stafford is back at quarterback, and he will lead the Rams throughout the season with Puka Nacua, Davante Adams, and Kyren Williams. Jared Verse and Braden Fiske will look to build upon stellar rookie campaigns on defense for the Rams.Make sure to subscribe to the Rams LAFB YouTube Channel and head to https://www.lafbnetwork.com for all of your Los Angeles Rams content needs!
Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.
Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.
Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.
In this episode of the Bioactive Podcast, Dr. Allyn Howlett—renowned neuroscientist and pioneer in cannabinoid research—shares her groundbreaking journey into the study of cannabis and the discovery of the CB1 receptor. Originally focused on neuronal hormones, Dr. Howlett recounts how her curiosity led to one of the most pivotal findings in medical cannabis science: the identification of the brain's first cannabinoid receptor. She dives into the mechanisms of THC, the function of cannabinoid receptors in the brain and body, and the discovery of the endocannabinoid system. The conversation explores the historical development of cannabinoid research, the barriers posed by the pharmaceutical industry, and the evolving relationship between academia and drug development. Dr. Howlett also discusses the future of cannabinoid science—including targeted therapies, pain relief, and the medical potential of cannabis compounds. This episode offers an essential look at the scientific foundation behind cannabis medicine and its impact on legalization, healthcare, and public perception.
The Buffalo Bills enter the 2025 NFL Draft with a glaring need at cornerback. While Christian Benford has solidified the CB1 spot, the CB2 position remains wide open—and fans are debating whether Brandon Beane should invest early or stick to his usual late-round magic. In this episode, we break down five potential cornerback targets who could reshape Buffalo's defense in 2025.Could the Bills finally take a swing on a top-tier corner in the first round? Or will a smart tradeback unlock new options? We analyze every angle, from Savion Riley's upside to Will Johnson's draft stock, and how late-season injuries and free agency still factor into the final decision.Topics Covered:CB2: The Bills' most underrated roster holeTop CB prospects in the 2025 NFL DraftInjury concerns, draft value & fit in McDermott's systemCould the Bills trade up or back in Round 1?Free agents still in play: Asante Samuel Jr., Rasul Douglas & moreWhat's your ideal CB pick for Buffalo this year? Drop your thoughts in the comments below.Go Bills!The Wandering Buffalo Podcast: A Buffalo Bills Podcast for April 8th, 2025.----------------------------------Sponsored by WearBUF - Buffalo Inspired Apparelhttps://www.wearbuf.com/ Use code "TWB" at checkout for 10% off your first order.----------------------------------If you like the Buffalo Bills, Buffalo Bills news today, and other Buffalo Bills content, connect with us!Stay up to date with all things Buffalo Bills: https://www.wanderingbuf.com/ Follow us on Twitter: https://www.twitter.com/TheWanderingBuf Follow us on Instagram: https://www.instagram.com/TheWanderingBuf Like us on Facebook: https://www.facebook.com/TheWanderingBuf Subscribe to The Wandering Buffalo Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-wandering-buffalo-podcast/id1553575732 Subscribe to The Wandering Buffalo Podcast on Spotify Podcasts: https://open.spotify.com/show/7HCluqByJZqhUQD9DJE0Iq ----------------------------------Host, Justin Goddard:Twitter -- https://www.twitter.com/jgods22 Instagram -- https://www.instagram.com/jgods22 Producer, Jakob Merkel:Twitter -- https://www.twitter.com/jakobmerkel Instagram -- https://www.instagram.com/jakobmerkel ----------------------------------The Wandering Buffalo Podcast is a part of the Buffalo FAMBase, the originators of #BillsMafia.Buffalo FAMBase is your #1 source for all of your Buffalo Bills news, Buffalo Bills updates, and everything else to do with the Buffalo Bills.Buffalo FAMBase Podcast Network: https://anchor.fm/buffalofambaseBuffalo FAMBase on YouTube: https://www.youtube.com/channel/UCu_JTz1SmD0Ml3D10HVQ50g Why the Buffalo Bills Locked In Christian Benford Early: Smartest Move of the Offseason?#BuffaloBills #GoBills #BillsMafia
The Buffalo Bills enter the 2025 NFL Draft with a glaring need at cornerback. While Christian Benford has solidified the CB1 spot, the CB2 position remains wide open—and fans are debating whether Brandon Beane should invest early or stick to his usual late-round magic. In this episode, we break down five potential cornerback targets who could reshape Buffalo's defense in 2025.Could the Bills finally take a swing on a top-tier corner in the first round? Or will a smart tradeback unlock new options? We analyze every angle, from Savion Riley's upside to Will Johnson's draft stock, and how late-season injuries and free agency still factor into the final decision.Topics Covered:CB2: The Bills' most underrated roster holeTop CB prospects in the 2025 NFL DraftInjury concerns, draft value & fit in McDermott's systemCould the Bills trade up or back in Round 1?Free agents still in play: Asante Samuel Jr., Rasul Douglas & moreWhat's your ideal CB pick for Buffalo this year? Drop your thoughts in the comments below.Go Bills!The Wandering Buffalo Podcast: A Buffalo Bills Podcast for April 8th, 2025.----------------------------------Sponsored by WearBUF - Buffalo Inspired Apparelhttps://www.wearbuf.com/ Use code "TWB" at checkout for 10% off your first order.----------------------------------If you like the Buffalo Bills, Buffalo Bills news today, and other Buffalo Bills content, connect with us!Stay up to date with all things Buffalo Bills: https://www.wanderingbuf.com/ Follow us on Twitter: https://www.twitter.com/TheWanderingBuf Follow us on Instagram: https://www.instagram.com/TheWanderingBuf Like us on Facebook: https://www.facebook.com/TheWanderingBuf Subscribe to The Wandering Buffalo Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-wandering-buffalo-podcast/id1553575732 Subscribe to The Wandering Buffalo Podcast on Spotify Podcasts: https://open.spotify.com/show/7HCluqByJZqhUQD9DJE0Iq ----------------------------------Host, Justin Goddard:Twitter -- https://www.twitter.com/jgods22 Instagram -- https://www.instagram.com/jgods22 Producer, Jakob Merkel:Twitter -- https://www.twitter.com/jakobmerkel Instagram -- https://www.instagram.com/jakobmerkel ----------------------------------The Wandering Buffalo Podcast is a part of the Buffalo FAMBase, the originators of #BillsMafia.Buffalo FAMBase is your #1 source for all of your Buffalo Bills news, Buffalo Bills updates, and everything else to do with the Buffalo Bills.Buffalo FAMBase Podcast Network: https://anchor.fm/buffalofambaseBuffalo FAMBase on YouTube: https://www.youtube.com/channel/UCu_JTz1SmD0Ml3D10HVQ50g Why the Buffalo Bills Locked In Christian Benford Early: Smartest Move of the Offseason?#BuffaloBills #GoBills #BillsMafia
Don't kink-shame the promiscuous CBD. It's okay that in a world of orthosteric normative binding, CBD is into allosteric binding. In fact, CBD is not just into any allosteric binding. CBD is into negative allosteric binding.If none of that makes any sense to you, don't worry. We are going to take a deep dive into how the famous cannabinoid, CBD, interacts with the cannabinoid receptor CB1. And it doesn't bind like a key into a lock, which is how pharmacy school told Trevor that all ligands bind to their receptors. Like all things cannabis, things are weirder, more complicated and more nuanced than our co-host, Trevor, thought. Put your science toques on and let's skate into some CB1 receptor research.Dr. Robert Laprairie BioDetermination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor A Combined Computational and Site Directed Mutagenesis Study Paper(Yes we got a SOCAN membership to use this song all legal and proper like)Music by:GameChops – Zelda and Chill 2(specifically at the 08:44 mark- Kass's theme)-YouTubeAdditional Music:Desiree Dorion desireedorion.comMarc Clement - FacebookTranscripts, papers and so much more at: reefermed.ca
Currently, the position that most experts have pegged the Los Angeles Rams to draft in the first round of the NFL Draft is cornerback.The Rams just recently re-signed Ahkello Witherspoon, but they still have a need, not only for depth but to find a true CB1.We take a look at all of the options that the Rams could target and who would be the best fit for the defense. Do you want them to take a CB in the first round?Make sure to like and subscribe to the Rams LAFB YouTube Channel!Listen to our Rams Podcast: https://www.lafbnetwork.com/nfl/la-rams/la-rams-podcast/Go to www.LAFBNetwork.com for FREE full access to all of our podcasts and join the community!Social Media: @LAFBNetwork | @RyanDyrudLAFB | @RLAndersonLAFB | @Brittany_Bets | @BaulaParrantes
Send us a textIf you're a Miami Dolphins fan, NFL Draft enthusiast, or East Texas A&M supporter, this is the video you need to watch! Kendall Paul is a shutdown cornerback with elite coverage skills, yet no one is talking about him ahead of the 2025 NFL Draft. Could he be the next great sleeper prospect?In this deep dive, we talk to Paul about his strengths, draft stock, and potential NFL fit—and why the Miami Dolphins should have him on their radar. We break down his college tape, combine projections, and scouting reports to see if he can become a future CB1 in the NFL.
The Endocannabinoid System plays a crucial role in regulating cardiovascular, neurological, and immune functions through CB1 and CB2 receptors. • CB1 Activation: Associated with oxidative stress, inflammation, and increased cardiovascular risks such as myocardial infarction (MI), arrhythmias, and heart failure. • CB2 Activation: Primarily found in immune cells and linked to anti-inflammatory and protective cardiovascular effects. • Cannabis Use: High THC content or synthetic cannabinoids (e.g., Spice, K2) significantly increases the risk of cardiovascular diseases and psychiatric disorders. • Cannabis Use Disorder (CUD): Characterized by compulsive use despite adverse consequences, often co-occurring with depression, PTSD, and anxiety. • Potential Therapeutic Targets: CB1 antagonists (e.g., Genistein) and CB2 agonists are being explored for their ability to reduce inflammation and vascular damage while minimizing psychiatric side effects. Future research is needed to clarify long-term cardiovascular effects, optimize cannabinoid therapies, and inform public health policies.
The Chargers got a ton out of a very young secondary in 2024, with a revolving door at safety3. Will they spend big at cornerback to solidify their CB1 spot? Will they need to replace Elijah Molden? Shaping up for an interesting offseason in the back 7. 0:00 Show start 3:58 Pre-discussion on DB room and Minter 18:24 Top of the 2025 market 31:46 Pricey starters 43:27 Starters on a budget and role players Make sure to join up as channel members at: https://www.youtube.com/channel/UCBnSd0Mx4BHUXlpxVegCoOg/join To make your selections, go to PrizePicks.com/GUILTY and use code GUILTY for a first deposit match up to $100! Follow us on Twitter! Podcast: @GACPodcast17 Steven: @StevenIHaglund Tyler: @tylerjschoon Tyler's Patreon: https://patreon.com/TylerSchoon?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink #BlueWireVideo #NFL #Chargers #NFLPodcasts Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode of Disguised Coverage, Anthony is joined by Kendall Mirsky for a high level discussion to set the table for the Buffalo Bills 2025 offseason. Roster needs, coaching adjustments, schematic/structural tweaks, and much more.After another disappointing end to another season at the hands of the Chiefs, what does the Bills offseason need to consist of to finally get over the hump #bills #buffalobills #nfl0:00 | Opening thoughts6:44 | Where the Buffalo Bills are22:17 | The need for a deep threat in some capacity44:41 | Run game focus and James Cook54:49 | BetUS graphic59:02 | Solving the run defense1:17:00 | What they do at CB1:24:05 | Solving the 3rd down struggles on defense1:34:36 | What they do at safety1:42:57| The 4 man rush 1:47:54| One Pie Pizza 1:49:06 | Closing thoughtsPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__AntFollow on Bluesky: https://bsky.app/profile/proant.bsky.socialPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__Ant Cover 1 would love to hear your thoughts on this topic and the show in general. Comment below and let us what you think!One Pass Premium Membership - https://www.cover1.net/onepass/Don't miss out on our PREMIUM CONTENT-Access to detailed Premium Content.-Access to our video library.-Access to our private Slack channel.-Sneak peek at upcoming content.-Exclusive group film room sessions & much more.Thank you for watching this video, we can't do it without the support of our fans. If you have any ideas for content you'd like to see from us, comment below. -DOWNLOAD THE COVER 1 MOBILE APP!► Android: https://play.google.com/store/apps/details?id=com.coverapp► iOS: https://apps.apple.com/us/app/id1532587486► Subscribe to our YouTube channel - https://www.youtube.com/channel/UClL6eJS1s8xmRoYRQbYgxQQ?sub_confirmation=1► Subscribe to our Cover 1 Network channel - https://podcasts.apple.com/us/podcast/cover-1-sports/id1370162953 -Cover 1 provides a multi-faceted analysis of the NFL and NFL Draft including Podcasts, Video blogs, Commentary, Scouting Reports, Highlights, and Video Breakdowns. NFL footage displayed is not owned by Cover 1. -Follow Us HereTwitter: https://twitter.com/Cover1Instagram: https://www.instagram.com/@Cover_1_Facebook: https://www.facebook.com/Cover1NFL/Official Merchandise:https://teespring.com/en-GB/stores/cover-1The Cover1.net website and associated Social Media platforms are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by the NFL or any of its clubs, specifically the Buffalo Bills. All products, marks, and company names are the registered trademarks of their original owners. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder of their product brand.
Episode 181: Cannabinoid Hyperemesis SyndromeFuture Dr. Johnson explains the pathophysiology, assessment, and management of Cannabinoid Hyperemesis syndrome. Dr. Arreaza adds some insights on the topic. Written by Tyler Johnson, MSIV, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific-Northwest. Editing and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic abdominal pain, vomiting, or nausea in older adolescents and adults who have chronic ϲаnոаbis use.The term “marijuana” is considered racist by some people. In the 1930s, American politicians popularized the term “marijuana” in the U.S. to portray the drug as a “Mexican vice” and to have a justification to persecute Mexican immigrants. Epidemiology The overall prevalence of cannabinoid hyperemesis syndrome is unknown due to a lack of definitive criteria or diagnostic tests. It occurs in a population that may not disclose substance use. One study conducted in 2015 in a United States urban emergency department not named, found one-third of patients with near-daily cannabis use met criteria for having had CНЅ in the prior six months.Why are rates of CHS increasing?Between 2005-2014 hospitalizations cyclic vomiting syndromes increased by 60 %. concurrent cannabis use in hospitalized patients increasing from 2 to 21 percent. 7 years after the commercialization of cannabis in Canada, the Canadian health services found a 13-fold increase in cyclic vomiting syndromesPotential correlations for the increase in CHS are increased legalization and commercialization of cannabis, higher tetrahydrocannabinol concentrations in cannabis products, and increased recognition of the syndrome.Legal status of Cannabis in the USCannabis is legal in 24 states: Alaska, Arizona, California, Colorado, Connecticut, Delaware, Illinois, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Jersey, New Mexico, New York, Ohio, Oregon, Rhode Island, Vermont, Virginia, and Washington. It is also legal in Washington, D.C. Cannabis is approved for medical use in 38 states.Federal level: Cannabis is a Schedule I drug, under the Controlled Substance Act (added in 1970) in the group of Hallucinogenic or psychedelic substances. Tetra-hydro-cannabinol (THC, a “mind-altering substance in cannabis”) is on the same list. However, cannabidiol (CBD, derived from hemp or non-hemp plants) was removed from the Controlled Substances Act in 2018. CBD is FDA-approved (under the name of Epidiolex®) to treat rare seizure disorders. CBD is still on the list of controlled substances in some states. I see THC as a problem.THC increased concentration As recreational Cannabis becomes more normalized, innovators look to find new ways to differentiate their product and increasing THC has become a common way to perform this similar to alcohol content in the beer, wine, and liquor industry. An article by Yale School of Medicine titled “Marijuana: Rising THC Concentrations in Cannabis Can Pose Health Risks” states, “In 1995, the average THC content in cannabis seized by the Drug Enforcement Administration was about 4%. By 2017, it had risen to 17% and continues to increase. Beyond the plant, a staggering array of other cannabis products with an even higher THC content like dabs, oils, and edibles are readily available—some as high as 90%.”Recently, cannabis-infused water started to be sold in some grocery stores.Pathophysiology of CHSIt is not entirely understood. Some suggest multifactorial involving cannabinoid metabolism, exposure dose and tolerance modifying receptor regulation, complex pharmacodynamics at Cannabinoid receptors, and even changes in genetics and cannabinoid variation in plants. CB1 receptors are involved in gastric secretion, sensation, motility, inflammation, and lipogenesis. The activation of CB1 and CB2 receptors has been suggested as the possible cause of CHS.Risk FactorsCHS can occur after acute or acute on chronic use but many report daily 3-5x cannabis use cannabis use over one year and many over at least two years. Median age 24 years. Interesting factsMedical visits for inhaled cannabis are more likely associated with CHS while edibles are more likely for acute psychiatric reactions.Also, CHS is a paradoxical effect since cannabis and cannabinoid receptor agonists are known antiemetics (as seen in nabilone and dronabinol (synthetic analogs of THC)) and prescribed by some physicians to combat chemotherapy effects.Clinical Features of CHSCyclical pattern with abdominal pain, severe nausea, and vomiting up to 30 episodes daily. Pain is intense and even referred to as “scromiting” due to its intense nature, causing patients to scream and vomit concurrently.Typically, it presents with 2 or more episodes over a 6-month period with no symptoms in between. It starts within 24 hours of last cannabis use (differentiating from cannabis withdrawal) and occurs at day or night. There is a gradual symptom resolution of nausea and vomiting after several days of cannabis cessation. Some patients had symptoms 2 days to 2 weeks after cessation. Diagnosis of CHSClinical diagnosisRule out neurological symptoms such as migraine headaches, acute abdomen, motion sickness, and medications, such as recent antibiotics and chemotherapy.Often the diagnosis is discovered with a thorough history reporting a decrease in symptoms with hot showers/baths.Management of CHS AcuteRehydrate with Fluids Dopamine Antagonists– Droperidol (0.625 or 1.25mg) /Haloperidol (0.05 to 0.1mg/kg with max dose of 5mg initially) favored over typical antiemetics like Zofran or Reglan.If needed, combine with an antiemetic like metoclopramide IM or ondansetron IV and consider patients' dehydration status likely requiring US-guided IV.Topical capsaicin cream 0.025 – 0.1% on the abdomen. Long term97% resolution of symptoms completely in a systematic review of patients who stopped cannabis use.Reinforce it may take several weeks of abstinence for symptoms to resolve and symptoms can worsen if cannabis is resumed. It is unknown if a reduction in use can prevent recurrence.Approaches in the clinicEducate patients on the etiology of their symptoms with complete cessation of cannabis use.Consider referral to counseling for cannabis use disorder and abstinence support for treatment-seeking cannabis users. Approach topics such as changing one's environment, seeking social support, and using self-help techniques to non-treatment-seeking individuals.Consider referring patients with polysubstance use and significant comorbidities to a supervised withdrawal management setting. Conclusion: Cannabis use is increasing with legalization and commercialization across the United States. With increased use, Cannabinoid hyperemesis syndrome incidence increases. Often it can be diagnosed with a thorough history including chronic cannabis consumption and symptomatic relief by showers. Physicians will need to develop counseling approaches to better understand CHS patients and how to approach an often-difficult topic.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Angulo MI. Cannabinoid Hyperemesis Syndrome. JAMA. 2024;332(17):1496. doi:10.1001/jama.2024.9716. Link: https://jamanetwork.com/journals/jama/fullarticle/2824833#:~:text=Cannabinoid%20hyperemesis%20syndrome%20(CHS,last%20less%20than%201%20week.Backman, Isabella, Marijuana: Rising THC Concentrations in Cannabis Can Pose Health Risks, Yale School of Medicine, August 30, 2023. https://medicine.yale.edu/news-article/not-your-grandmothers-marijuana-rising-thc-concentrations-in-cannabis-can-pose-devastating-health-risks/Buchanan, Jennie A and George Sam Wang, Cannabinoid Hyperemesis Syndrome, Up To Date, updated July 17, 2024. https://www.uptodate.com/contents/cannabinoid-hyperemesis-syndromeTheme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.
JP Finlay and Mitch Tischler join you for a good old emergency podcast as the Commanders trade for former Saints corner Marshon Lattimore. Lattimore was 2017 Defensive Rookie of the Year and a four time pro bowler with New Orleans, and he gives the Commanders a bonafide CB1 to solidify the defense. The guys also catch up with long time NFL OL Jon Feliciano who played for now Commanders OL Coach Bobby Johnson and had some complimentary things to say about the guy thats leading one of the most improved units in all of the NFL.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Commanders: analysis of the Commanders on 2024 NFL Trade Deadline Day trading for New Orleans Saints cornerback Marshon Lattimore, including the great trade terms that Commanders general manager Adam Peters negotiated for his team, key stats regarding Lattimore being a true CB1, the favorable contractual situation that the Commanders are inheriting with this trade, Lattimore's troubling recent injury history and reaction to the trade from head coach Dan Quinn and prominent NFL media members Guest: Ross Jackson, host of the Locked On Saints podcast and Saints analyst for WWL-TV in New Orleans, on what the Commanders are getting in trading for Saints cornerback Marshon Lattimore, including how he is a shutdown cornerback, why he is viewed as the best cornerback in Saints history, the right way of looking at his significant recent injury history, the truth about his tension with now-fired Saints head coach Dennis Allen and more Call Nova Fireplace And Stove at 571-513-3803, mention that Al Galdi sent ya and receive $25 off any fireplace or chimney service Visit RonMurrayWellness.com and mention that Al Galdi sent you Download the PrizePicks app and use the promo code "Galdi" for $50 instantly after you play your first $5 lineup Learn more about your ad choices. Visit podcastchoices.com/adchoices
Michael-Shawn and Christopher dive into their One Big Thing after watching the tape of the Seahawks' 34-14 win over the Falcons. Chris' One Big Thing: What a difference maker Byron Murphy II was in his return to the lineup. Mike's One Big Thing: Geno Smith's pocket presence and how critical that will be moving forward. Also, Buffalo News writer Katherine Fitzgerald joins the show to preview Week 8 with a look at Josh Allen's hot start, the addition of Amari Cooper, James Cook's contribution to the ground game, Greg Rousseau's potential to have a big day, Buffalo's CB1 against Seattle's wideouts and more. Interested in advertising on this podcast? Email sales@bluewirepods.com! Learn more about your ad choices. Visit podcastchoices.com/adchoices
We love to hear from our listeners. Send us a message. While the trend toward CB1 inhibition for obesity took a small hit with the release of Novo Nordisk's small molecule oral cannabinoid receptor (CB1) inverse agonist monlunabant last month, Skye Bioscience Chairman and CEO Punit Dhillon is shaking it off. He's confident that his company's antibody-based approach to CB1 inhibition will make a moot point of the neuropsychiatric side effects that put a damper on Novo's data. On this episode of the Business of Biotech, we're digging into the uber-hot business of weight loss therapeutics and going deep with Dhillon on why Skye's blood/brain barrier-obeying antibody might turn the GLP-1 and small molecule approaches to obesity on their ears. Over the course of the conversation, we explore the ins-and-outs of the business of metabolic health, a space that's churning out one blockbuster after another. Access this and hundreds of episodes of the Business of Biotech videocast under the Listen & Watch tab at bioprocessonline.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: matt.pillar@lifescienceconnect.comFind Matt Pillar on LinkedIn: https://www.linkedin.com/in/matthewpillar/
Our guest this week is David “Zeb” Cook as we continue our Gary Con 2024 series of 50 years of Dungeons and Dragons interviews. We talk about his involvement in 49 of the 50 years of D&D's existence and how satisfying it's been for him to see his work impacting generations of people.We discuss his late 1970s start at TSR by editing Queen of the Demonweb Pits (Q1), writing Slave Pits of the Undercity (A1) as the first project that he wrote at TSR, running tournaments at the very earliest Gen Cons and Origins, how Dwellers of the Forbidden City came from his writing sample to get the job at TSR. We talk about his love of Conan, writing the first Conan module Conan Unchained! (CB1) and writing the Conan Role-Playing Game.TSR in the 1980s: growth from a staff of gamers and hobbyists to running a successful company. Dealing with the Satanic Panic. Being lead designer on the 2nd edition AD&D. Worked on D&D through 1994 with Planescape and some smaller projects before moving on to video games. Follow Zeb at: Wikipedia - FB - Amazon —ANNOUNCEMENTSGamehole Con: October 17th through 20th in Madison, Wisconsin. We'll have a booth right up front in the Podcasters and Press section. Come say hi to Dragon Warrior and pick up some Dungeon Cats and Mad Dungeon season three Rise of the Vat Spawn swag!PAX Unplugged: December 6th through 8th in Philadelphia. Come say hi to Tiger Wizard at the Exalted Funeral booth, and play some games with Dragon Warrior every morning at the Alexandria RPG Library room.Dungeon Cats: Tiger Wizard's rules-lite TTRPG where you play feline adventures is now available at Exalted Funeral. Delve into lush carpeted dungeons to vanquish giant rats, demonic dog spawn and the half full food bowl. You only have 9 lives. Live them adventurously!THE MEGA DUNGEON MEN EP: Our new TTRPG fantasy meets hip hop album, The Mega Dungeon Men EP, with features from nerdcore legends Mega Ran and MC Frontalot, is now available on all streaming platforms.JOIN OUR MAILING LIST by clicking the newsletter button at epiclevelsrapgods.com—Thanks for listening to Season Three of the Epic Levels Mad Dungeon podcast, where D&D hip hop group Epic Levels alternate between “Rise of the Vat Spawn,” an actual play using Mystic Punks RPG, and Side Quests where we interview other game creators.You can support us via Patreon for early episode releases, bonus map content, extra art, access to our discord server, and lots of other exclusive goodies.Get nerd merch and stay up to date with socials: HEREMad Dungeon is hosted by Andrew Bellury, Steve Albertson, Robin Bellury and produced by Zach Cowan.Theme song by Epic Levels and beat by Jay Domingo.© 2024 Epic Levels. All characters in our adventures–even those based on real people–are entirely fictional.
Dan and Nick rack up their first mailbag of the 2024 season and Schneier's thrilled about it because there are no more fun podcasts in lost seasons than these ones! They rip off a slew of questions, trying their best to fit everyone in with the spillover landing on the preview pod (at the end). Discussions of the future for the regime, what they need to see to keep Schoen, Daboll, what's next for the QB and the offensive line and a lot more are answered. They discuss Brian Burns, the future CB1 and a lot more as well. It's a jampacked episode with almost every one of your questions answered. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Nick Kendell discusses ESPN's Jeff Legwold's recent article discussing Denver and their Cornerback Two Spot. With Patrick Surtain II and Ja'Quan McMillian starting at CB1 and nickel, who will rise up and take the final starting cornerback spot? Can Mathis step up and make up for last year's faltering? Will Moss be healthy and show why Denver traded up for him two drafts ago? Will the veteran Levi Wallace provide steady play? Will darkhorse rookie Kris Abrams-Draine be a surprising starter? Subscribe to Mile High Huddle Podcasts: https://www.bluewirepods.com/podcast/mile-high-huddle Nick Kendell: https://twitter.com/NickKendellMHH Scott Kennedy: https://www.youtube.com/c/scottkennedy?sub_confirmation=1 Merch: http://mhhmerch.com/ Slam it here for more Broncos coverage: http://milehighhuddle.com Mile High Huddle Live Stream Schedule (All Times MT) Sunday - 6:00 p.m. Mile High Huddle Podcast Monday - 7:30 a.m. Broncos for Breakfast Monday - 6:00 p.m. Mile High Huddle Podcast Tuesday - 6:00 p.m. Building the Broncos Wednesday - 7:30 a.m. Broncos for Breakfast Wednesday - 6:00 p.m. Mile High Insiders Thursday - 6:00 p.m. Mile High Huddle Podcast Friday - 6:00 p.m. Dove Valley Deep Divers Saturday - 6:00 p.m. Orange and Blue View Learn more about your ad choices. Visit podcastchoices.com/adchoices
Matt continues his series on the impact of cannabis, THC, and CBD upon sleep this week with an examination into the intricacies of cannabidiol (CBD), which, unlike its psychoactive counterpart THC, does not induce a high but is recognized for its potential therapeutic effects. While studies suggest that CBD may aid in alleviating anxiety, movement disorders, pain, and addiction, in this episode, our host focuses on exploring CBD's potential influence on sleep quality while examining its biochemistry and neurobiology.Matt explains that CBD modulates the body's endocannabinoid system without directly binding to cannabinoid receptors like CB1 and CB2, which THC targets. Instead, CBD enhances the activity of natural endocannabinoids, extending their effectiveness. This modulation can promote sleep by increasing deep non-REM sleep, as demonstrated in both animal and human studies. Despite these promising results, Matt emphasizes that the effects of CBD on sleep are complex and dose-dependent, with higher doses showing potential benefits. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm', and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He's also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!The good people at InsideTracker are one of the sponsors of this week's episode, and they are generously offering a special 25% off any one of their programs for anyone who uses the above link during the time window of this episode. InsideTracker is a personalized biometric platform that analyzes your blood and your DNA to better understand what's happening inside of you.Another exciting sponsor is Levels, the groundbreaking continuous glucose monitor that keeps track of your blood sugar levels day and night. Whether you're curious about your body's response to different foods or seeking to enhance your sleep quality, Levels has the answers. If you're interested, visit levels.link/Mattwalker now to grab an exclusive podcast offer of two free months of this impactful service, and take charge of your health journey today!As always, if you have thoughts or feedback you'd like to share, please reach out to Matt on Instagram.
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