Podcasts about cb1

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

In this episode of the Bioactive Podcast, Dr. Allyn Howlett—renowned neuroscientist and pioneer in cannabinoid research—shares her groundbreaking journey into the study of cannabis and the discovery of the CB1 receptor. Originally focused on neuronal hormones, Dr. Howlett recounts how her curiosity led to one of the most pivotal findings in medical cannabis science: the identification of the brain's first cannabinoid receptor. She dives into the mechanisms of THC, the function of cannabinoid receptors in the brain and body, and the discovery of the endocannabinoid system. The conversation explores the historical development of cannabinoid research, the barriers posed by the pharmaceutical industry, and the evolving relationship between academia and drug development. Dr. Howlett also discusses the future of cannabinoid science—including targeted therapies, pain relief, and the medical potential of cannabis compounds. This episode offers an essential look at the scientific foundation behind cannabis medicine and its impact on legalization, healthcare, and public perception.

The Buffalo Bills enter the 2025 NFL Draft with a glaring need at cornerback. While Christian Benford has solidified the CB1 spot, the CB2 position remains wide open—and fans are debating whether Brandon Beane should invest early or stick to his usual late-round magic. In this episode, we break down five potential cornerback targets who could reshape Buffalo's defense in 2025.Could the Bills finally take a swing on a top-tier corner in the first round? Or will a smart tradeback unlock new options? We analyze every angle, from Savion Riley's upside to Will Johnson's draft stock, and how late-season injuries and free agency still factor into the final decision.Topics Covered:CB2: The Bills' most underrated roster holeTop CB prospects in the 2025 NFL DraftInjury concerns, draft value & fit in McDermott's systemCould the Bills trade up or back in Round 1?Free agents still in play: Asante Samuel Jr., Rasul Douglas & moreWhat's your ideal CB pick for Buffalo this year? Drop your thoughts in the comments below.Go Bills!The Wandering Buffalo Podcast: A Buffalo Bills Podcast for April 8th, 2025.----------------------------------Sponsored by WearBUF - Buffalo Inspired Apparelhttps://www.wearbuf.com/ Use code "TWB" at checkout for 10% off your first order.----------------------------------If you like the Buffalo Bills, Buffalo Bills news today, and other Buffalo Bills content, connect with us!Stay up to date with all things Buffalo Bills: https://www.wanderingbuf.com/ Follow us on Twitter: https://www.twitter.com/TheWanderingBuf Follow us on Instagram: https://www.instagram.com/TheWanderingBuf Like us on Facebook: https://www.facebook.com/TheWanderingBuf Subscribe to The Wandering Buffalo Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-wandering-buffalo-podcast/id1553575732 Subscribe to The Wandering Buffalo Podcast on Spotify Podcasts: https://open.spotify.com/show/7HCluqByJZqhUQD9DJE0Iq ----------------------------------Host, Justin Goddard:Twitter -- https://www.twitter.com/jgods22 Instagram -- https://www.instagram.com/jgods22 Producer, Jakob Merkel:Twitter -- https://www.twitter.com/jakobmerkel Instagram -- https://www.instagram.com/jakobmerkel ----------------------------------The Wandering Buffalo Podcast is a part of the Buffalo FAMBase, the originators of #BillsMafia.Buffalo FAMBase is your #1 source for all of your Buffalo Bills news, Buffalo Bills updates, and everything else to do with the Buffalo Bills.Buffalo FAMBase Podcast Network: https://anchor.fm/buffalofambaseBuffalo FAMBase on YouTube: https://www.youtube.com/channel/UCu_JTz1SmD0Ml3D10HVQ50g Why the Buffalo Bills Locked In Christian Benford Early: Smartest Move of the Offseason?#BuffaloBills #GoBills #BillsMafia

The Buffalo Bills enter the 2025 NFL Draft with a glaring need at cornerback. While Christian Benford has solidified the CB1 spot, the CB2 position remains wide open—and fans are debating whether Brandon Beane should invest early or stick to his usual late-round magic. In this episode, we break down five potential cornerback targets who could reshape Buffalo's defense in 2025.Could the Bills finally take a swing on a top-tier corner in the first round? Or will a smart tradeback unlock new options? We analyze every angle, from Savion Riley's upside to Will Johnson's draft stock, and how late-season injuries and free agency still factor into the final decision.Topics Covered:CB2: The Bills' most underrated roster holeTop CB prospects in the 2025 NFL DraftInjury concerns, draft value & fit in McDermott's systemCould the Bills trade up or back in Round 1?Free agents still in play: Asante Samuel Jr., Rasul Douglas & moreWhat's your ideal CB pick for Buffalo this year? Drop your thoughts in the comments below.Go Bills!The Wandering Buffalo Podcast: A Buffalo Bills Podcast for April 8th, 2025.----------------------------------Sponsored by WearBUF - Buffalo Inspired Apparelhttps://www.wearbuf.com/ Use code "TWB" at checkout for 10% off your first order.----------------------------------If you like the Buffalo Bills, Buffalo Bills news today, and other Buffalo Bills content, connect with us!Stay up to date with all things Buffalo Bills: https://www.wanderingbuf.com/ Follow us on Twitter: https://www.twitter.com/TheWanderingBuf Follow us on Instagram: https://www.instagram.com/TheWanderingBuf Like us on Facebook: https://www.facebook.com/TheWanderingBuf Subscribe to The Wandering Buffalo Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-wandering-buffalo-podcast/id1553575732 Subscribe to The Wandering Buffalo Podcast on Spotify Podcasts: https://open.spotify.com/show/7HCluqByJZqhUQD9DJE0Iq ----------------------------------Host, Justin Goddard:Twitter -- https://www.twitter.com/jgods22 Instagram -- https://www.instagram.com/jgods22 Producer, Jakob Merkel:Twitter -- https://www.twitter.com/jakobmerkel Instagram -- https://www.instagram.com/jakobmerkel ----------------------------------The Wandering Buffalo Podcast is a part of the Buffalo FAMBase, the originators of #BillsMafia.Buffalo FAMBase is your #1 source for all of your Buffalo Bills news, Buffalo Bills updates, and everything else to do with the Buffalo Bills.Buffalo FAMBase Podcast Network: https://anchor.fm/buffalofambaseBuffalo FAMBase on YouTube: https://www.youtube.com/channel/UCu_JTz1SmD0Ml3D10HVQ50g Why the Buffalo Bills Locked In Christian Benford Early: Smartest Move of the Offseason?#BuffaloBills #GoBills #BillsMafia

Don't kink-shame the promiscuous CBD. It's okay that in a world of orthosteric normative binding, CBD is into allosteric binding. In fact, CBD is not just into any allosteric binding. CBD is into negative allosteric binding.If none of that makes any sense to you, don't worry. We are going to take a deep dive into how the famous cannabinoid, CBD, interacts with the cannabinoid receptor CB1. And it doesn't bind like a key into a lock, which is how pharmacy school told Trevor that all ligands bind to their receptors. Like all things cannabis, things are weirder, more complicated and more nuanced than our co-host, Trevor, thought. Put your science toques on and let's skate into some CB1 receptor research.Dr. Robert Laprairie BioDetermination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor A Combined Computational and Site Directed Mutagenesis Study Paper(Yes we got a SOCAN membership to use this song all legal and proper like)Music by:GameChops – Zelda and Chill 2(specifically at the 08:44 mark- Kass's theme)-YouTubeAdditional Music:Desiree Dorion desireedorion.comMarc Clement - FacebookTranscripts, papers and so much more at: reefermed.ca

Currently, the position that most experts have pegged the Los Angeles Rams to draft in the first round of the NFL Draft is cornerback.The Rams just recently re-signed Ahkello Witherspoon, but they still have a need, not only for depth but to find a true CB1.We take a look at all of the options that the Rams could target and who would be the best fit for the defense. Do you want them to take a CB in the first round?Make sure to like and subscribe to the Rams LAFB YouTube Channel!Listen to our Rams Podcast: https://www.lafbnetwork.com/nfl/la-rams/la-rams-podcast/Go to www.LAFBNetwork.com for FREE full access to all of our podcasts and join the community!Social Media: @LAFBNetwork | @RyanDyrudLAFB | @RLAndersonLAFB | @Brittany_Bets | @BaulaParrantes

Send us a textIf you're a Miami Dolphins fan, NFL Draft enthusiast, or East Texas A&M supporter, this is the video you need to watch! Kendall Paul is a shutdown cornerback with elite coverage skills, yet no one is talking about him ahead of the 2025 NFL Draft. Could he be the next great sleeper prospect?In this deep dive, we talk to Paul about his strengths, draft stock, and potential NFL fit—and why the Miami Dolphins should have him on their radar. We break down his college tape, combine projections, and scouting reports to see if he can become a future CB1 in the NFL.

The Endocannabinoid System plays a crucial role in regulating cardiovascular, neurological, and immune functions through CB1 and CB2 receptors. • CB1 Activation: Associated with oxidative stress, inflammation, and increased cardiovascular risks such as myocardial infarction (MI), arrhythmias, and heart failure. • CB2 Activation: Primarily found in immune cells and linked to anti-inflammatory and protective cardiovascular effects. • Cannabis Use: High THC content or synthetic cannabinoids (e.g., Spice, K2) significantly increases the risk of cardiovascular diseases and psychiatric disorders. • Cannabis Use Disorder (CUD): Characterized by compulsive use despite adverse consequences, often co-occurring with depression, PTSD, and anxiety. • Potential Therapeutic Targets: CB1 antagonists (e.g., Genistein) and CB2 agonists are being explored for their ability to reduce inflammation and vascular damage while minimizing psychiatric side effects.   Future research is needed to clarify long-term cardiovascular effects, optimize cannabinoid therapies, and inform public health policies.

The Chargers got a ton out of a very young secondary in 2024, with a revolving door at safety3. Will they spend big at cornerback to solidify their CB1 spot? Will they need to replace Elijah Molden? Shaping up for an interesting offseason in the back 7. 0:00 Show start 3:58 Pre-discussion on DB room and Minter 18:24 Top of the 2025 market 31:46 Pricey starters 43:27 Starters on a budget and role players Make sure to join up as channel members at: https://www.youtube.com/channel/UCBnSd0Mx4BHUXlpxVegCoOg/join To make your selections, go to PrizePicks.com/GUILTY and use code GUILTY for a first deposit match up to $100! Follow us on Twitter! Podcast: @GACPodcast17 Steven: @StevenIHaglund Tyler: @tylerjschoon Tyler's Patreon: https://patreon.com/TylerSchoon?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink #BlueWireVideo #NFL #Chargers #NFLPodcasts Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Disguised Coverage, Anthony is joined by Kendall Mirsky for a high level discussion to set the table for the Buffalo Bills 2025 offseason. Roster needs, coaching adjustments, schematic/structural tweaks, and much more.After another disappointing end to another season at the hands of the Chiefs, what does the Bills offseason need to consist of to finally get over the hump #bills #buffalobills #nfl0:00 | Opening thoughts6:44 | Where the Buffalo Bills are22:17 | The need for a deep threat in some capacity44:41 | Run game focus and James Cook54:49 | BetUS graphic59:02 | Solving the run defense1:17:00 | What they do at CB1:24:05 | Solving the 3rd down struggles on defense1:34:36 | What they do at safety1:42:57| The 4 man rush 1:47:54| One Pie Pizza 1:49:06 | Closing thoughtsPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__AntFollow on Bluesky: https://bsky.app/profile/proant.bsky.socialPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__Ant Cover 1 would love to hear your thoughts on this topic and the show in general. Comment below and let us what you think!One Pass Premium Membership - https://www.cover1.net/onepass/Don't miss out on our PREMIUM CONTENT-Access to detailed Premium Content.-Access to our video library.-Access to our private Slack channel.-Sneak peek at upcoming content.-Exclusive group film room sessions & much more.Thank you for watching this video, we can't do it without the support of our fans. If you have any ideas for content you'd like to see from us, comment below. -DOWNLOAD THE COVER 1 MOBILE APP!► Android: https://play.google.com/store/apps/details?id=com.coverapp► iOS: https://apps.apple.com/us/app/id1532587486► Subscribe to our YouTube channel - https://www.youtube.com/channel/UClL6eJS1s8xmRoYRQbYgxQQ?sub_confirmation=1► Subscribe to our Cover 1 Network channel - https://podcasts.apple.com/us/podcast/cover-1-sports/id1370162953 -Cover 1 provides a multi-faceted analysis of the NFL and NFL Draft including Podcasts, Video blogs, Commentary, Scouting Reports, Highlights, and Video Breakdowns. NFL footage displayed is not owned by Cover 1. -Follow Us HereTwitter: https://twitter.com/Cover1Instagram: https://www.instagram.com/@Cover_1_Facebook: https://www.facebook.com/Cover1NFL/Official Merchandise:https://teespring.com/en-GB/stores/cover-1The Cover1.net website and associated Social Media platforms are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by the NFL or any of its clubs, specifically the Buffalo Bills. All products, marks, and company names are the registered trademarks of their original owners. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder of their product brand.

Episode 181: Cannabinoid Hyperemesis SyndromeFuture Dr. Johnson explains the pathophysiology, assessment, and management of Cannabinoid Hyperemesis syndrome. Dr. Arreaza adds some insights on the topic.  Written by Tyler Johnson, MSIV, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific-Northwest. Editing and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic abdominal pain, vomiting, or nausea in older adolescents and adults who have chronic ϲаnոаbis use.The term “marijuana” is considered racist by some people. In the 1930s, American politicians popularized the term “marijuana” in the U.S. to portray the drug as a “Mexican vice” and to have a justification to persecute Mexican immigrants. Epidemiology The overall prevalence of cannabinoid hyperemesis syndrome is unknown due to a lack of definitive criteria or diagnostic tests. It occurs in a population that may not disclose substance use. One study conducted in 2015 in a United States urban emergency department not named, found one-third of patients with near-daily cannabis use met criteria for having had CНЅ in the prior six months.Why are rates of CHS increasing?Between 2005-2014 hospitalizations cyclic vomiting syndromes increased by 60 %. concurrent cannabis use in hospitalized patients increasing from 2 to 21 percent. 7 years after the commercialization of cannabis in Canada, the Canadian health services found a 13-fold increase in cyclic vomiting syndromesPotential correlations for the increase in CHS are increased legalization and commercialization of cannabis, higher tetrahydrocannabinol concentrations in cannabis products, and increased recognition of the syndrome.Legal status of Cannabis in the USCannabis is legal in 24 states: Alaska, Arizona, California, Colorado, Connecticut, Delaware, Illinois, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Jersey, New Mexico, New York, Ohio, Oregon, Rhode Island, Vermont, Virginia, and Washington. It is also legal in Washington, D.C. Cannabis is approved for medical use in 38 states.Federal level: Cannabis is a Schedule I drug, under the Controlled Substance Act (added in 1970) in the group of Hallucinogenic or psychedelic substances. Tetra-hydro-cannabinol (THC, a “mind-altering substance in cannabis”) is on the same list. However, cannabidiol (CBD, derived from hemp or non-hemp plants) was removed from the Controlled Substances Act in 2018. CBD is FDA-approved (under the name of Epidiolex®) to treat rare seizure disorders. CBD is still on the list of controlled substances in some states. I see THC as a problem.THC increased concentration As recreational Cannabis becomes more normalized, innovators look to find new ways to differentiate their product and increasing THC has become a common way to perform this similar to alcohol content in the beer, wine, and liquor industry. An article by Yale School of Medicine titled “Marijuana: Rising THC Concentrations in Cannabis Can Pose Health Risks” states, “In 1995, the average THC content in cannabis seized by the Drug Enforcement Administration was about 4%. By 2017, it had risen to 17% and continues to increase. Beyond the plant, a staggering array of other cannabis products with an even higher THC content like dabs, oils, and edibles are readily available—some as high as 90%.”Recently, cannabis-infused water started to be sold in some grocery stores.Pathophysiology of CHSIt is not entirely understood. Some suggest multifactorial involving cannabinoid metabolism, exposure dose and tolerance modifying receptor regulation, complex pharmacodynamics at Cannabinoid receptors, and even changes in genetics and cannabinoid variation in plants. CB1 receptors are involved in gastric secretion, sensation, motility, inflammation, and lipogenesis. The activation of CB1 and CB2 receptors has been suggested as the possible cause of CHS.Risk FactorsCHS can occur after acute or acute on chronic use but many report daily 3-5x cannabis use cannabis use over one year and many over at least two years. Median age 24 years. Interesting factsMedical visits for inhaled cannabis are more likely associated with CHS while edibles are more likely for acute psychiatric reactions.Also, CHS is a paradoxical effect since cannabis and cannabinoid receptor agonists are known antiemetics (as seen in nabilone and dronabinol (synthetic analogs of THC)) and prescribed by some physicians to combat chemotherapy effects.Clinical Features of CHSCyclical pattern with abdominal pain, severe nausea, and vomiting up to 30 episodes daily. Pain is intense and even referred to as “scromiting” due to its intense nature, causing patients to scream and vomit concurrently.Typically, it presents with 2 or more episodes over a 6-month period with no symptoms in between. It starts within 24 hours of last cannabis use (differentiating from cannabis withdrawal) and occurs at day or night. There is a gradual symptom resolution of nausea and vomiting after several days of cannabis cessation. Some patients had symptoms 2 days to 2 weeks after cessation. Diagnosis of CHSClinical diagnosisRule out neurological symptoms such as migraine headaches, acute abdomen, motion sickness, and medications, such as recent antibiotics and chemotherapy.Often the diagnosis is discovered with a thorough history reporting a decrease in symptoms with hot showers/baths.Management of CHS AcuteRehydrate with Fluids Dopamine Antagonists– Droperidol (0.625 or 1.25mg) /Haloperidol (0.05 to 0.1mg/kg with max dose of 5mg initially) favored over typical antiemetics like Zofran or Reglan.If needed, combine with an antiemetic like metoclopramide IM or ondansetron IV and consider patients' dehydration status likely requiring US-guided IV.Topical capsaicin cream 0.025 – 0.1% on the abdomen. Long term97% resolution of symptoms completely in a systematic review of patients who stopped cannabis use.Reinforce it may take several weeks of abstinence for symptoms to resolve and symptoms can worsen if cannabis is resumed. It is unknown if a reduction in use can prevent recurrence.Approaches in the clinicEducate patients on the etiology of their symptoms with complete cessation of cannabis use.Consider referral to counseling for cannabis use disorder and abstinence support for treatment-seeking cannabis users. Approach topics such as changing one's environment, seeking social support, and using self-help techniques to non-treatment-seeking individuals.Consider referring patients with polysubstance use and significant comorbidities to a supervised withdrawal management setting. Conclusion: Cannabis use is increasing with legalization and commercialization across the United States. With increased use, Cannabinoid hyperemesis syndrome incidence increases. Often it can be diagnosed with a thorough history including chronic cannabis consumption and symptomatic relief by showers. Physicians will need to develop counseling approaches to better understand CHS patients and how to approach an often-difficult topic.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Angulo MI. Cannabinoid Hyperemesis Syndrome. JAMA. 2024;332(17):1496. doi:10.1001/jama.2024.9716. Link: https://jamanetwork.com/journals/jama/fullarticle/2824833#:~:text=Cannabinoid%20hyperemesis%20syndrome%20(CHS,last%20less%20than%201%20week.Backman, Isabella, Marijuana: Rising THC Concentrations in Cannabis Can Pose Health Risks, Yale School of Medicine, August 30, 2023. https://medicine.yale.edu/news-article/not-your-grandmothers-marijuana-rising-thc-concentrations-in-cannabis-can-pose-devastating-health-risks/Buchanan, Jennie A and George Sam Wang, Cannabinoid Hyperemesis Syndrome, Up To Date, updated July 17, 2024. https://www.uptodate.com/contents/cannabinoid-hyperemesis-syndromeTheme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Send us a textThe New York Giants have officially entered a new chapter in their turbulent 2024 season. Head coach Brian Daboll announced a monumental shift in the quarterback position, benching Daniel Jones in favor of Tommy DeVito. This decision, confirmed by NFL insider Ian Rapoport, comes as the Giants struggle at 2-8 and look to retool for the future. Daboll stated that the move was made after thorough evaluation and praised DeVito for the spark he showed last year. Financial implications aside, this decision marks a significant pivot for the Giants. Daboll also hinted at further roster evaluations, suggesting that underperforming players could see reduced roles as the team focuses on assessing talent for 2025 and beyond. While ownership reportedly supports Daboll for now, insiders like Jordan Schultz report that the next seven games are critical for the head coach. Daboll's decision to start DeVito could be a last-ditch effort to reignite the offense and prove his worth to ownership, especially amid increasing speculation about his future with the team.  Roster problems extend far beyond the quarterback position. Deonte Banks, who was expected to solidify the secondary, has struggled in his second year, leaving the Giants in desperate need of a true CB1. On the defensive line, Dexter Lawrence continues to dominate as one of the league's premier nose tackles, but the rest of the unit has underwhelmed, particularly in run defense. The offensive line, once a persistent weakness, still faces questions, especially with free agent Greg Van Roten potentially departing. Wide receiver and tight end positions remain areas of concern, with players like Darius Slayton and Chris Manhertz also set to hit free agency.  Looking to the future, the Giants are poised to make bold moves in free agency and the draft. Cutting Daniel Jones and others could free up over $60 million in cap space, allowing the team to pursue veteran quarterbacks to bridge the gap until a rookie is ready to start. Free-agent targets may include Taylor Heinicke, Sam Darnold, or even Justin Fields, depending on cost and availability. In the draft, projections suggest Miami QB Cam Ward could be the team's top pick. Other potential draftees include Kenneth Grant, a defensive tackle with elite run-stopping skills, and Quincy Riley, a cornerback with developmental upside.  Free agency and the draft are not the only areas of focus. Key re-signings like WR Darius Slayton, OL Greg Van Roten, and EDGE Azeez Ojulari are vital to maintaining continuity and addressing depth concerns. Meanwhile, veterans like QB Drew Lock and CB Adoree Jackson are unlikely to return, further emphasizing the need for strategic acquisitions to stabilize the roster.  Despite the team's struggles, ownership reportedly values continuity, with Adam Schefter suggesting that Daboll and Schoen are likely safe for now. However, this commitment to stability is contingent on the team's performance over the next seven games. Giants fans will watch closely as the team navigates this critical stretch, knowing that their franchise's direction hangs in the balance.  #giants #nygiants #giants100Support the showAll Episodes are shot LIVE with fan interactions on Youtube, Facebook, Twitter, & TwitchSponsor the show at: https://www.buymeacoffee.com/2giantgoofballsInterested in starting a podcast. We recommend using buzzsprout: https://www.buzzsprout.com/?referrer_id=2012368

JP Finlay and Mitch Tischler join you for a good old emergency podcast as the Commanders trade for former Saints corner Marshon Lattimore. Lattimore was 2017 Defensive Rookie of the Year and a four time pro bowler with New Orleans, and he gives the Commanders a bonafide CB1 to solidify the defense. The guys also catch up with long time NFL OL Jon Feliciano who played for now Commanders OL Coach Bobby Johnson and had some complimentary things to say about the guy thats leading one of the most improved units in all of the NFL.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Commanders: analysis of the Commanders on 2024 NFL Trade Deadline Day trading for New Orleans Saints cornerback Marshon Lattimore, including the great trade terms that Commanders general manager Adam Peters negotiated for his team, key stats regarding Lattimore being a true CB1, the favorable contractual situation that the Commanders are inheriting with this trade, Lattimore's troubling recent injury history and reaction to the trade from head coach Dan Quinn and prominent NFL media members Guest: Ross Jackson, host of the Locked On Saints podcast and Saints analyst for WWL-TV in New Orleans, on what the Commanders are getting in trading for Saints cornerback Marshon Lattimore, including how he is a shutdown cornerback, why he is viewed as the best cornerback in Saints history, the right way of looking at his significant recent injury history, the truth about his tension with now-fired Saints head coach Dennis Allen and more Call Nova Fireplace And Stove at 571-513-3803, mention that Al Galdi sent ya and receive $25 off any fireplace or chimney service Visit RonMurrayWellness.com and mention that Al Galdi sent you Download the PrizePicks app and use the promo code "Galdi" for $50 instantly after you play your first $5 lineup Learn more about your ad choices. Visit podcastchoices.com/adchoices

Former NFL defensive back Will Blackmon joins Craig to break down the Commanders' major NFL Trade Deadline move, acquiring four-time Pro Bowler Marshon Lattimore. Blackmon shares insights into the challenges Lattimore might face in quickly adapting to new defensive checks and schemes midseason. He also highlights Lattimore's value as the Commanders' new CB1, explaining the stability and elevated play he'll bring to Washington's secondary as they aim to build on their strong start to the season.

In the patient populations treated by neurologists, central neuropathic pain develops most frequently following spinal cord injury, multiple sclerosis, or stroke. To optimize pain relief, neurologists should have a multimodal and individualized approach to manage central neuropathic pain. In this episode, Lyell K. Jones Jr, MD, FAAN, speaks with Charles E. Argoff, MD, author of the article “Central Neuropathic Pain,” in the Continuum October 2024 Pain Management in Neurology issue. Dr. Jones is the editor-in-chief of Continuum: Lifelong Learning in Neurology® and is a professor of neurology at Mayo Clinic in Rochester, Minnesota. Dr. Argoff is a professor of neurology and vice chair of the department of neurology, director of the Comprehensive Pain Management Center, and director of the Pain Management Fellowship at Albany Medical College in Albany, New York. Additional Resources Read the article: Central Neuropathic Pain Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @LyellJ Full episode transcript available here Dr Jones: This is Doctor Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum Journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Jones: This is Doctor Lyell Jones, Editor-in-Chief of Continuum: Lifelong Learning in Neurology. Today I'm interviewing Dr Charles Argoff, who recently authored an article on central neuropathic pain in the latest issue of Continuum covering pain management. Dr Argoff is a neurologist at Albany Medical College where he's a professor of Neurology, and he serves as vice chair of the Department of Neurology and program director of the Pain Medicine Fellowship Program there. Dr Argoff, welcome. Thank you for joining us today. Why don't you introduce yourself to our listeners?  Dr Argoff: I'm Charles Argoff. It's a pleasure to be here and thank you so much for that kind introduction. Dr Jones: I've read your article. Many of our listeners are going to read your article. Wonderful article, extremely helpful. Closes a lot of gaps, I think, that exist in our field about understanding central neuropathic pain, treating central neuropathic pain. You now, Doctor Argoff, you have the attention of a huge audience of mostly neurologists. What's the biggest point you would like to make to them, or the most important practice-changing advice that you would give to them? Dr Argoff: I think it's at least twofold. One is that central neuropathic pain is not as uncommon as you think it might be, and it occurs in a variety of settings that are near and dear to a neurologist's heart, so to speak. And secondly, although we live in an evidence-based world and we want to practice evidence-based medicine - and I'm proud to have formerly been a member of the Quality Standard subcommittee, which I think has changed its name over time. And so, I understand the importance of, you know, treatment based upon evidence - the true definition of evidence-based medicine is using the best available evidence in making decisions about individual patients. And so, I would urge those who are listening that, although there might not be as robust evidence currently as you'd like, please don't not take the time to try to treat the patient in front of you o r at least acknowledge the need for treatment and work with your colleagues to address the significant neuropathic pain associated with that central neurological disorder. Because it can be life-changing in a positive way to make even a dent and to really work with somebody, even though not clear-cut always what's going to work for an individual patient. Dr Jones: Well said. I'm glad you brought that up. So, to put it a different way, absence of evidence is not an excuse for absence of treatment. Right? Dr Argoff: Exactly. And I think that, I hope that we would agree that especially in neurology, what we do is about as far from, ‘Yep, you've got strep throat, here's that antibiotic that's going to work for you and all you have to do is take the medicine.' I mean, most of what we do is nowhere near that.  Dr Jones: It's complicated stuff. And this is a complicated topic. And I'll tell you, I learned a lot reading your article. I think most of us in neurology and medicine, when we hear the term neuropathic pain, it feels roughly synonymous with peripheral generators of that pain, such as diabetic neuropathy or posttraumatic neuralgia. But as you mentioned, there's central mechanisms for pain generation. How is it defined? What is central neuropathic pain? Dr Argoff: It's defined as pain caused by a lesion or disease of the central somatosensory system . Though neuropathic pain in general is pain associated with the lesion of the somatosensory system; and to your point, that can be peripheral, which of course is outside the spinal cord, or brain or central, which is within the spinal cord or brain. And central neuropathic pain is defined specifically as pain caused by a lesion or disease of the central somatosensory system. That's either brain or spinal cord. But there's an interesting follow-up, and I'm going to ask if you could remind me because I know we're talking about definitions now, but I'll just bring something up and we can come back to it. What's interesting about that is that my - whoever 's listening, that's not to say that they're not connected. And in fact, they are very much connected. And there's very new work, which I included in the article, down at Washington University in Saint Louis, that suggests you can actually affect central neuropathic pain by addressing peripheral input to the central nervous system. If you remember Ken Casey at the University of Michigan at the World Pain Congress in Vancouver, British Columbia many years ago, he ended his talk on pain with a limerick, of which the last line was, Remember, there ain't no such thing as pain without a brain. And so that kind of summarizes that. Dr Jones: Well, and it goes both ways too, right? We know that there's some central sensitization that can happen with peripheral generators, right? So we really have to think about the whole circuit. Dr Argoff: Yes. And that's been sometimes the bane of my existence as a colleague of others and a sometimes debater. Is the pain central? Is it peripheral? Well, it's everything. And it's important to know as many of the mechanisms and many of the targets that you could use for treatment so that you can affect the best outcome for your patients. Dr Jones: Yeah, so - and you mentioned in your article what some of the common causes of central neuropathic pain are. What are the big ones in your experience?  Dr Argoff: So, the biggest ones are spinal cord injury-related pain, MS-related pain - and I'd like to come back to a point and just if I do the third one - and central poststroke pain. And what struck me, I think Tim Vollmer published a survey about the incidence, the prevalence of ongoing pain in patients with multiple sclerosis. And it blew my mind several years ago because it was incredibly high. Like in this survey of MS patients who, you never hear about pain, you hear about these modifying treatments, all the wonderful expanses that have been made. I mean, like seventy something percent of people say they have moderate to severe pain. And when you think about how sensory processing occurs, it makes perfect sense that a demyelinating disorder is going to interrupt the flow of information for a person to feel normal.  Dr Jones: Yeah, I think it's a good example of, there are things that we tend to focus on as clinicians where we worry about deficit and function and capacity. But if we're patient-centered and we ask patients what they care about, pain usually moves up higher on the list. And so, I think that's why we, it's maybe underrecognized with some of those central disorders, right? Dr Argoff: I think so, and I and I think you hit the nail on the head that - and we're also trained that way. I tell this to my patients very often so that they are reassured when I examine them and I say, and I tell them that everything looked pretty OK. It's not a medical term, I understand that. Because what we do in a typical neurological exam, even if it's detailed, doesn't really address all the intricacies of the nervous system. So it's really a big picture and sensory processing and especially picking up sensory deficits; you know, we use quantitative sensory testing and research studies and things like that, but bedside testing may not reveal the subtle changes. And when we don't see overt changes, we often think - that can lead someone to think that everything is OK and it's not. Dr Jones: So, when you when you see a patient who you've diagnosed with a central mechanism, so central neuropathic pain, how do you approach the management of those patients, Dr Argoff? Dr Argoff: I always review what treatments and what approaches have been addressed already. And I see if - a handful of time, we actually just submitted a paper for publication regarding this in a group of patients with pelvic pain who had untreated, difficult-to-treat chronic pelvic pain, seen all the urological kinds, gynecological things. Look, we picked up two patients who had unknown MS. So, it's just interesting when it comes down to that level. And we also picked up some patients who had subacute combined degeneration. So that's another central kind of disorder as well. Again, the neurologist in us says to make sure that we have specific diagnosis that underlies the central neuropathic pain. And so interestingly, of course, for somebody with MS - or even though it's uncommon, it could be more than one. Somebody with MS might have a stroke, somebody with MS might have a cord injury due to cervical, you know, joint disc disease. Not to overcomplicate things. Know the lay of the land, know the conditions, know what you're battling and lay out so that you can treat the treatable; you want to treat whatever you can correct? So, for MS you simply want to have the best disease-modifying treatment on board, tolerable and appropriate for that person, and so on. And then you really want to take a history of past treatments - and your treatments can be everything and anything, including behavioral modification, physical rehabilitative approaches, as well as pharmacologic management. That's - as I think I put in my article, we concentrated in the article on pharmacologic management because honestly, that's what most patients are looking for, is ‘what can we, what can you do to help me now, in addition to what I can do myself.' And that's what we typically think of. There are also some more interventional approaches, invasive options, that have developed over time. And of course, those are the ones, some of them, especially in neuromodulation, that we have the least information about, but it appears somewhat promising.  Dr Jones: No, that's exactly what we need to hear. And you also mentioned something that I think is important. This is a common theme throughout the issue because I think it's true for the management of many different types of pain and interdisciplinary approach. In other words, not just honing in on pharmacotherapy or neuromodulation as a one-size-fits-all magic pill, right? So, that - tell us a little bit more about that interdisciplinary approach and how that's important for these patients. Dr Argoff: So, let me back up and give an example. Let's look at Botox for chronic migraine. So, the pre-M studies that led to the approval of Botox for chronic migraine: two treatment sessions versus two random, two placebo session in different patients. The mean headache frequency was, let's say, fifteen to twenty in each group. It was like seventeen, eighteen, something like that. But the mean pain headache day reduction was somewhere between four and five after two treatments compared to a lesser, a lower number in the placebo group. So, if you think about that, that means that you went from nineteen, let's say, to fourteen, thirteen, or twelve. Want to be generous, eleven or ten. But that means that person, everyone 's happy. We use treatment. We have better data than that because the longer you use it, the better it gets in general, but it means that people are still going to be symptomatic. So that drives home in a different painful disorder the importance of yes, treatment can be effective, but it's not the only treatment that a person is going to likely need. And so, I think that's what's so important about multidisciplinary approach. I- we may affect positive changes, reduction in pain intensity with a particular pharmacologic agent, but we don't anticipate it's like taking an antibiotic or a strep throat, not curative. And so, we want to, early on, to explain that logically, methodically, step by step. There are many options for you and we're going to, you know, systematically go through them. And I may need to call in some colleagues to help because I don't do everything. No one does everything, right? But don't feel as if there isn't any hope because there is. If we were to use intraspinal Baclofen for someone who has painful spasticity following a stroke or a spinal cord injury, combining that with physical therapy might give more effect, maybe synergistic. Some targeted muscles, some local muscles may not respond as well to the intraspinal Baclofen, so is that - what can we do? Well, we could use oral agents or we might be able to target that with botulinum toxin, and so on and so forth. So it's limitless, virtually, in what you can do. Dr Jones: There's kind of setting expectations and letting people know that you, you're going to need a lot of different approaches, right? To sort of get them the best possible outcome. Dr Argoff: Yeah, I think that's so important. And of course, no matter what we try to set out, there are going to be individuals - for those of you who are listening, we all know - who expect to be cured yesterday. That might be challenging for us not only to actually complete, but also, it's challenging for some individuals to appreciate that we're with them, we're going to work with them. It'll be a process, but we've got your back. Dr Jones: Great. And you know, this is a question that I get all the time from patients and from other clinicians is, you know, what about cannabinoids? What's the role of cannabinoids for the management of central neuropathic pain? Dr Argoff: First, I'll say that the short answer to that is we don't know. The second part of my response would be, there is new evidence that it might be helpful in the acute treatment of migraine. And I'm happy to say that the editor of this edition of Continuum is the person who developed that evidence, and it's been recently presented at the American Headache Society. But the challenge and the conundrum that we all face is, everywhere within our nervous system where there's pain being processed, there are endocannabinoid receptors. There also happen to be opioid receptors, but that's a separate issue. And the endocannabinoid system, the peripheral or central, you know, CB1, CB2, is very, very important, but we haven't figured out a way of harnessing that knowledge in developing an analgesic, an effective analgesic. And part of that is that there are so many chemical agents that have cannabinoid properties and there are different… the right balance has not yet been found. But even the legalization, the available of medical cannabis, hasn't led to a standardized approach to evaluating if a preparation does help. And that's part of the conundrum. It's like saying, ‘does medicine work?'Well, yeah, sometimes. But which medicine? Which receptor? How do you harness the right ratio between TBD, THC, other active agents, et cetera? And I think maybe as we go forward in the future, we'll be able to do that with - more precise. I mentioned Dr Schuster's study in which he had defined ratios of THC effect and CBD and was able to clearly show effect based upon that. But the average person going into a dispensary doesn't really get that. We don't get to study that. Each person's an NF1  and it's not very helpful to understand how to do that. I would say, as I'm sure you remember, there was a practice parameter that was published probably over a decade ago about using cannabis symptomatically in different neurological disorders. And I believe that it was what they studied or what they reviewed was helpful in MS-related urinary discomfort and spasticity, but not necessarily pain.  Dr Jones: And we're still in the early days of studying it, right? Dr Argoff: Yes.  Dr Jones: That's part of the point, as we got started late and we're still waiting for high-quality evidence. And I guess, if you look at the horizon, Dr Argoff, or the future of management of central neuropathic pain, what's going to be the next big thing?  Dr Argoff: One of the joys of being asked to get involved in a project like this is that inevitably we learn so many new things because, you know, that's when anyone says, oh, you must be an expert, I say, I don't know anything because I'm always learning something new. One of the reasons why I moved to Albany Medical College about seventeen years ago was to be able to further my interest in studying why people benefit from topical analgesics by working with a scientist at Albany Med who studied keratinocyte neurochemistry and its impact on pain transmission. And that's a separate issue, but it indicates my love for the peripheral nervous system. And one of my thoughts historically, that is, what the central nervous system processes is what it processes and it might get input, as you mentioned earlier, from the peripheral nervous system, so that topical agents could be dampening central mechanisms. And lo and behold, as I was doing research for this article, I learned that people doing peripheral nerve blocks - so blocking peripheral input at the into the spinal cord - at Washington University, Simon Guterian and colleagues, demonstrate that they could give prolonged benefit from central pain by blocking peripheral input. And that's wild because certainly the nervous system is a two-way street. It's an understatement. What I really found amazing was that, again, blocking input helped the injured central nervous system to behave better.  Dr Jones: That is kind of cool to think about. And I'll tell you, as editor of the journal, one of the funnest things is getting to learn all about neurology, including pain and including central neuropathic pain, when in the end you're doing all the work, I just get to sit here and enjoy it. And you're a program director of a pain fellowship. What's the pipeline look like? Are neurologists more interested in pain than they used to be?  Dr Argoff: I'm happy for this. We are seeing more and more applicants from neurology into our pain management programs. I would say… I was going to say tragically. If I say tragically, it's because what specialty better understands how to diagnose, figure out, assess, come to a conclusion? You can't have pain without your brain. It's always amazed me that more neurologists weren't interested, and I understand the background and such. Just like in migraine, it's only advances in understanding mechanisms of migraine that allow neuroscientific advances that are leading to great therapeutics - that's happening and increasing in ‘pain.' Today, as program director, we had our fellowship interviews earlier today and three of the nine applicants that we interviewed were neurologists. Last week, I think we interviewed two or three also. That would not have happened five years ago or six years ago. And if you think about it, we can not only diagnose, quote-unquote figure out what's happening, but we now, with pain management training, we can offer people a variety of both invasive and noninvasive options, all while understanding what we're doing with respect to the nervous system in a way that's different than the other specialties that typically go into pain med. And that's such - for me, it's a beautiful experience and something I really enjoy doing. There isn't a neurological condition in the most part that either doesn't have pain associated with it or doesn't have mechanisms that overlap. If you think about epilepsy, and please don't think I'm crazy, but epilepsy is associated with disinhibited hyper-excitatory behavior, just to put it loosely, among certain neurons. That's what pain and neuropathic pain is about too. And you, in fact, we know that several mechanisms since now what medicines are used for both. But what was interesting since, if I may just go back to another point, one of the advances since I brought up the migraine that's very exciting is the whole story about sodium channels. Dr Harouthounian at WashU and his group used lidocaine injection. Lidocaine's a more generalized sodium channel blocker, but some of the newest treatments for treating neuropathic pain. Our NAV specific sodium channel blocker's trying to match up mechanism to treatment. Not exactly the way that we do with migraine, but still a step forward to not just generally treat but really target different neuronal mechanisms. It's an exciting time.  Dr Jones: So, the pipeline is doing better because we're getting better understanding of disease, and hopefully that pulls in more interest because obviously there are big gaps in caring for patients with pain. And again, thank you, Dr Argoff, for an amazing article. Thank you for joining us and thank you for such a fascinating discussion. I enjoyed the article. I read the article, I learned from our conversation today. So, thank you for joining us to talk about central neuropathic pain. Dr Argoff: Thank you for having me. Dr Jones: Again, we've been speaking with Dr Charles Argoff, author of an article on central neuropathic pain in Continuum 's most recent issue on pain management. Please check it out, and thank you to our listeners for joining today. Dr Monteith: This is Doctor Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

The 2024 Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA. It's too bad we at Reefer MEDness don't know anything about microRNA. But wait…We do! Hilal Kalkan, a post-doc at Laval University, talks to us about how microRNA and cannabinoid receptors are involved in the side effect of a common cholesterol medication. Come dive deep into the molecular workings of the endocannabinoid system with us!Hilal Kalkan - LinkedInDysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin, Hilal Kalkan et al. - Paper in Cell Death and Disease(Yes we got a SOCAN membership to use this song all legal and proper like)Music by:Tuğba Yurt - Benim O -YouTubeAdditional Music:Desiree Dorion desireedorion.comMarc Clement - FacebookTranscripts, papers and so much more at: reefermed.ca

Michael-Shawn and Christopher dive into their One Big Thing after watching the tape of the Seahawks' 34-14 win over the Falcons. Chris' One Big Thing: What a difference maker Byron Murphy II was in his return to the lineup. Mike's One Big Thing: Geno Smith's pocket presence and how critical that will be moving forward. Also, Buffalo News writer Katherine Fitzgerald joins the show to preview Week 8 with a look at Josh Allen's hot start, the addition of Amari Cooper, James Cook's contribution to the ground game, Greg Rousseau's potential to have a big day, Buffalo's CB1 against Seattle's wideouts and more. Interested in advertising on this podcast? Email sales@bluewirepods.com! Learn more about your ad choices. Visit podcastchoices.com/adchoices

We love to hear from our listeners. Send us a message. While the trend toward CB1 inhibition for obesity took a small hit with the release of Novo Nordisk's small molecule oral cannabinoid receptor (CB1) inverse agonist monlunabant last month, Skye Bioscience Chairman and CEO Punit Dhillon is shaking it off. He's confident that his company's antibody-based approach to CB1 inhibition will make a moot point of the neuropsychiatric side effects that put a damper on Novo's data. On this episode of the Business of Biotech, we're digging into the uber-hot business of weight loss therapeutics and going deep with Dhillon on why Skye's blood/brain barrier-obeying antibody might turn the GLP-1 and small molecule approaches to obesity on their ears. Over the course of the conversation, we explore the ins-and-outs of the business of metabolic health, a space that's churning out one blockbuster after another. Access this and hundreds of episodes of the Business of Biotech videocast under the Listen & Watch tab at bioprocessonline.com. Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: matt.pillar@lifescienceconnect.comFind Matt Pillar on LinkedIn: https://www.linkedin.com/in/matthewpillar/

Our guest this week is David “Zeb” Cook as we continue our Gary Con 2024 series of 50 years of Dungeons and Dragons interviews. We talk about his involvement in 49 of the 50 years of D&D's existence and how satisfying it's been for him to see his work impacting generations of people.We discuss his late 1970s start at TSR by editing Queen of the Demonweb Pits (Q1), writing Slave Pits of the Undercity (A1) as the first project that he wrote at TSR, running tournaments at the very earliest Gen Cons and Origins, how Dwellers of the Forbidden City came from his writing sample to get the job at TSR. We talk about his love of Conan, writing the first Conan module Conan Unchained! (CB1) and writing the Conan Role-Playing Game.TSR in the 1980s: growth from a staff of gamers and hobbyists to running a successful company. Dealing with the Satanic Panic. Being lead designer on the 2nd edition AD&D. Worked on D&D through 1994 with Planescape and some smaller projects before moving on to video games. Follow Zeb at: Wikipedia - FB - Amazon —ANNOUNCEMENTSGamehole Con: October 17th through 20th in Madison, Wisconsin. We'll have a booth right up front in the Podcasters and Press section. Come say hi to Dragon Warrior and pick up some Dungeon Cats and Mad Dungeon season three Rise of the Vat Spawn swag!PAX Unplugged: December 6th through 8th in Philadelphia. Come say hi to Tiger Wizard at the Exalted Funeral booth, and play some games with Dragon Warrior every morning at the Alexandria RPG Library room.Dungeon Cats: Tiger Wizard's rules-lite TTRPG where you play feline adventures is now available at Exalted Funeral. Delve into lush carpeted dungeons to vanquish giant rats, demonic dog spawn and the half full food bowl. You only have 9 lives. Live them adventurously!THE MEGA DUNGEON MEN EP: Our new TTRPG fantasy meets hip hop album, The Mega Dungeon Men EP, with features from nerdcore legends Mega Ran and MC Frontalot, is now available on all streaming platforms.JOIN OUR MAILING LIST by clicking the newsletter button at epiclevelsrapgods.com—Thanks for listening to Season Three of the Epic Levels Mad Dungeon podcast, where D&D hip hop group Epic Levels alternate between “Rise of the Vat Spawn,” an actual play using Mystic Punks RPG, and Side Quests where we interview other game creators.You can support us via Patreon for early episode releases, bonus map content, extra art, access to our discord server, and lots of other exclusive goodies.Get nerd merch and stay up to date with socials: HEREMad Dungeon is hosted by Andrew Bellury, Steve Albertson, Robin Bellury and produced by Zach Cowan.Theme song by Epic Levels and beat by Jay Domingo.© 2024 Epic Levels. All characters in our adventures–even those based on real people–are entirely fictional.

The cell and gene therapy sector may be on the road to recovery after being met with investment headwinds following the highs seen during the pandemic, according to data presented Monday at the 2024 Cell & Gene Meeting on the Mesa hosted by the Alliance for Regenerative Medicine. BioSpace News Editor Greg Slabodkin reports from Phoenix. Last week, news broke that WuXi AppTec and WuXi Biologics, two companies named in the BIOSECURE Act, are looking to unload facilities in the U.S. and abroad as uncertainty looms over their U.S. business prospects. As Eli Lilly resolves shortages of its GLP-1 blockbusters, the company remains confident in its massive lead, along with competitor Novo Nordisk, over other companies with weight loss drug candidates—GLP-1s or other modalities such as next-gen CB1 inhibitors—looking to compete in the lucrative space. Not only are both companies making deals to expand their pipelines beyond GLP-1s, Lilly and Novo are actively pursuing broader markets for their current diabetes and weight loss blockbusters. Meanwhile, Big Pharma's layoffs continue with announcements last week from Bayer, J&J and Pfizer.

Dan and Nick rack up their first mailbag of the 2024 season and Schneier's thrilled about it because there are no more fun podcasts in lost seasons than these ones! They rip off a slew of questions, trying their best to fit everyone in with the spillover landing on the preview pod (at the end). Discussions of the future for the regime, what they need to see to keep Schoen, Daboll, what's next for the QB and the offensive line and a lot more are answered. They discuss Brian Burns, the future CB1 and a lot more as well. It's a jampacked episode with almost every one of your questions answered. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Disguised Coverage, Anthony dives into the initial Buffalo Bills 53-man roster now that the dust had settled on final cuts. Surprises, areas of strength, areas of worry, what to expect going forward, and much more0:00 | Opening thoughts6:48 | Cut down day surprises18:24 | Buffalo Bills roster "wants" going forward30:02 | Buffalo Bills roster - QB36:36 | Buffalo Bills roster - RB & FB47:53 | Buffalo Bills roster - WR & TE1:09:42 | Buffalo Bills roster - O-Line1:15:10 | One Pie Pizza1:16:23 | Buffalo Bills roster - edge1:26:07 | Buffalo Bills roster - IDL1:29:55 | Buffalo Bills roster - LB1:35:20 | Buffalo Bills roster - CB1:42:34 | Buffalo Bills roster - safety1:54:35 | Buffalo Bills roster - kicker & punter1:56:35 | Closing ThoughtsCheck out the "Buffalo Bills 2024 Offensive Outlook w/ Mina Kimes" episode of Disguised Coverage here: https://youtu.be/O6fc180B_kwPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__Ant Cover 1 would love to hear your thoughts on this topic and the show in general. Comment below and let us what you think!One Pass Premium Membership - https://www.cover1.net/onepass/Don't miss out on our PREMIUM CONTENT-Access to detailed Premium Content.-Access to our video library.-Access to our private Slack channel.-Sneak peek at upcoming content.-Exclusive group film room sessions & much more.Thank you for watching this video, we can't do it without the support of our fans. If you have any ideas for content you'd like to see from us, comment below. -DOWNLOAD THE COVER 1 MOBILE APP!► Android: https://play.google.com/store/apps/details?id=com.coverapp► iOS: https://apps.apple.com/us/app/id1532587486► Subscribe to our YouTube channel - https://www.youtube.com/channel/UClL6eJS1s8xmRoYRQbYgxQQ?sub_confirmation=1► Subscribe to our Cover 1 Network channel - https://podcasts.apple.com/us/podcast/cover-1-sports/id1370162953 -Cover 1 provides a multi-faceted analysis of the NFL and NFL Draft including Podcasts, Video blogs, Commentary, Scouting Reports, Highlights, and Video Breakdowns. NFL footage displayed is not owned by Cover 1. -Follow Us HereTwitter: https://twitter.com/Cover1Instagram: https://www.instagram.com/@Cover_1_Facebook: https://www.facebook.com/Cover1NFL/Official Merchandise:https://teespring.com/en-GB/stores/cover-1The Cover1.net website and associated Social Media platforms are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by the NFL or any of its clubs, specifically the Buffalo Bills. All products, marks, and company names are the registered trademarks of their original owners. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder of their product brand.

Steve and Charlie listened to press conference audio from LSU star LT Will Campbell, who previewed the Tigers' upcoming 2024 season. Koki Riley, an LSU reporter for The Advocate, joined Steve and Charlie to break down the Tiger football team's fall camp. Riley praised LSU's weapons in the passing attack. He highlighted Ashton Stamps' improvement to take the Tigers' CB1 role at camp. Riley also reviewed the confidence of LSU's roster entering the season. The guys spoke to a WWL listener about Brandon Ingram. 

Koki Riley, an LSU reporter for The Advocate, joined Steve and Charlie to break down the Tiger football team's fall camp. Riley praised LSU's weapons in the passing attack. He highlighted Ashton Stamps' improvement to take the Tigers' CB1 role at camp. Riley also reviewed the confidence of LSU's roster entering the season. 

Hello and welcome to Healthy Mind Healthy Life with your host Eric. This podcast is all about exploring the latest research, sharing personal stories, and providing personal tips for improving our mental health and well-being. Each episode will be joined by experts in the field of mental health, as well as individuals who have experienced the transformative power of a healthy mind firsthand. Together, we will dive into a range of topics from managing stress and anxiety to building resilience and cultivating happiness. So join us on this journey to discover new ways to take care of our minds, bodies, and souls, and let's work together to create a healthier, happier world one episode at a time. So let's get started. Hello dear listeners, welcome to Healthy Waves, the live group podcast where we dive deep into the sea of topics with the experts who bring their wealth of knowledge and insights to our discussions. I'm your host and together we will explore the nuances of the mental and the physical wellbeing and also at the same time, uncover the new perspectives and provide the practical advice to help you lead a healthier and more fulfilling life. So. But before we delve deep into the topic, because today's topic is very great, where we'll be talking about from shadows to the serenity, like harnessing the power of your mind to overcome the addiction, trauma, chronic illness, and others. So, uh, but before we do that, uh, I really love to introduce you to all of our guests. So we'll start with Dave. Dave. Maury. So, uh, the listeners, Dave, uh, lives with the bipolar disorder and is the beacon of hope and the humor for many. So as the bestselling author of the OMG That's me mental health books and stand up comic, he teaches others with the mental illness how to find humor in the darkest days. So his journey from hospitalization and homelessness, uh, to becoming a transformative figure in the mental health is nothing short of inspiring. So through his work, uh, Dave shatters the stigma, shares laughter, and offers a message of resilience and recovery. So welcome to the show, Dave. Thank you. Okay. So we'll quickly also introduce you to our, uh, next guest, Micheal Martin. So, uh, like, following a series of life changing events, Michael turned of nature and turned to nature to find that inner peace and heal himself. So after a difficult, uh, divorce, he embarked on a solo backpacking trip that led him to reconnect with the, uh, tranquility and the resilience of the natural world. So his journey of self-discovery and the emotional healing in the wilderness has given him a renewed sense of peace and the purpose which he now shares to inspire others. Also, we have, on the other hand, we have Len Len May. So he is a pioneer in the, uh, uh, medical cannabis industry and the CEO and the co-founder of Endo DNA with over 25 years of experience, Lin has shaped the legislation and culture around the cannabis, and his expertise in genomics and, um, uh, into the system has revolutionized the personalized health and the, uh, wellness. So, uh, his mission is to educate and empower the individuals through the healing powers of cannabis and the personalized medicine. So welcome to the show, Len. And, uh. Uh, Michael. Thanks for having me. Appreciate it. Lovely, lovely. So to start with, uh, I'll quickly, uh, start with Martin. Uh, so, so, uh, so, Michael, like, uh, to start with, I mean, how do you I mean, how did your solo backpacking trip to the wilderness contribute to your emotional and mental healing after, uh, uh, the phase you've been through? Uh, and what lessons did you learn during that journey? So I think overall through that journey, I rediscovered something that somebody took away from me, which was my sense of self-worth, my sense of self value. And it expanded and really took shape once I learned to embrace the idea of meditation. And once I started working that into my practice of sitting in the wilderness and learning how to befriend myself and befriend the different emotions that I was struggling with, I started to gain a sense of balance and peace and that journey. It's taught me to not only rely on the skill set that I've learned throughout life, but it's also taught me to be open to the different examples that I encounter within the living world around me. Okay. Okay. So, um. Okay. Thanks. Thanks for sharing. Uh, this. Michael. So, uh, I'll come to the, like the, like, uh, uh, so exploring the humor in the healing, uh, if you can share with us, like, how the humor became, uh, pivotal tool in your recovery journey and also, at the same time, how it can transform the lives of those with the mental illness. Um, I had a breakdown in in 1996 and from 1996 to 2010, where my last years, my dark days, uh, suffering in silence. Um, just hiding from from everyone. And then in 2010, I took a stand up comedy class for folks with mental illness, and it changed my life. Instead of, uh, me having the thought and, uh, about a past trauma and reliving that experience, I started to look for the humor in in those triggers, those things that would trigger those, those, uh, memories and, and take me to those darkest places. And once I started doing that, it again, it changed. It changed everything. I, I when the trigger happened, uh, I no longer went to those dark places. I looked for the humor in it, and, like, Lynn was talking. You know, Lynn's talking about cannabis. And I have a cannabis joke. When, uh, when cannabis was legalized in in Oregon, uh, we got a new airline. It's called Air Cannabis, and they don't charge it by how far you go, but by how high you get. So you know, it does a couple things. One, it it it, uh, made a huge difference in my life. And then I teach standup comedy to others, and I see the same transformation in them. And, you know, I'll be able to talk a little bit about that. Um, but it it also helps shatter the stigma. People, when people find out I'm bipolar, uh, you know, they tend to back away and, and actually run away as fast as they can. But by including some humor, it humanizes me. It makes it so much less scary and helps shatter the stigma. Lovely. Thank you. Thank you so much for sharing. Yeah. So I'll come to Len. Um, so after that joke. Definitely. So, uh, we'll, uh, so regarding that personalized health through the, uh, genomics, uh, if you can, if you can share, I mean, how, uh, know DNAs technology harness the power of DNA to provide that personalized, uh, health recommendations and how this can be beneficial for the individuals who are dealing with the chronic illness. Yeah. I just want to say that Dave and I got the orange memo, and I think Mike didn't get the memo, so we're, uh, we're we're very coordinated today. Uh, so, uh, I didn't check my email before this. My apologies. Yeah. I'm sorry. Uh, so I wanted to, uh, kind of take a step back and really explain to people. And I really appreciate everybody's sharing their personal journeys, because that's what it is. Uh, we are all individuals, and we all should be treated personally, individually, and not like one size fits all. Uh, medicine and wellness. That's what. That's how we treat it today. And, you know, focusing on the root cause of something instead of addressing with a pill or a shot. So I just want to say, you know, I always focused on we started with the endocannabinoid system. That was that was my goal because I was noticing I was a dispensary owner at the time, had five different dispensaries under the same brand, uh, in Southern California. And, uh, I was noticing that people would consume the same chemical variety and have a completely different experience. And the first thing I did, I focused on a plant genomics. So doing genetic sequencing in the plant, we named this plan different names, but it really doesn't mean anything. It's what the components of the plant are that you're putting in your body. So once I started realizing that, I started looking at the human genetic side and merging those two together, not defined. You know, what is the ultimate plan? It's to help people avoid or mitigate possible adverse events. So now your DNA is your personalized roadmap. So this is your human, uh, G.P.S. system. It shows you where your own personal potholes are in your road. Where is there your own personal traffic jam. So if you're aware of this, it's empowering because you can then, uh, create lifestyle, uh, modifications to be able to avoid those possible personal potholes along the way. So the way that it works is, you know, we have a it's a saliva based test you swab into your cheek or your register because we're a hippo, we're GDPR compliant. It's medical data. You send it over to our lab, we'll sequence that and genotype that and provide you a report. So like I said, uh, it's it's focusing on your endocannabinoid system first. But now we expanded the whole genome and we're providing precision, uh, wellness and precision therapeutic, uh, suggestions across the board. So we have like, uh, for women. Uh, female hormone health. So looking at predisposition and menopause. Perimenopause post menopause. Extremely helpful to women who have a predisposition to something that they can actually turn off the genetic expression by taking certain things in advance. Also, it helps their significant others because we had a lot of calls from husbands and boyfriends saying, thanks, you saved my marriage because I don't have to deal with my wife going through certain, you know, genetic challenges based on her menopause. So we have a male hormone health, we have neutral genomics or personalized supplements and, and, uh, and vitamins, etc., skin, etc., even even canine, uh, for dogs. But the concept is you book an the experience starting with DNA, giving you a suggestion, then being able to have a feedback loop on how is that working for the individual and using AI to be able to start creating predictive inferences. So the next person that comes into a healthcare professionals office, you can say, you know what, there was 100 people that were similar to your genetics that took this protocol and showed that it was efficacious, that it worked for them. And that's the way, you know, you really building personalized precision health and wellness and medicine. And, Mr. Minister, thank you for sharing this. Yeah. Yeah, yeah. That's amazing. Yeah, exactly, exactly. We talk about it. I don't want to step on anybody's toes because you're moderating this. But you talk about, you know, addiction. You talk about mental health and all of these things. Well, I just want to make a couple of statements. Number one, there's a very large percentage of human beings that have a treatment resistant gene. So we have these, uh, you know, antidepressant, anti-anxiety medications. We go to a psycho pharmacologist. They look at us, they diagnosis, and they say, all right, here's your medication, here's your SSRI, etc. well, guess what? Maybe close to 30% of the population has a predisposition to treatment resistance. So they're going to get their pill. It's not going to work for them but they'll get all the side effects from that. So why are we not making that standard practice to be able to do that? Additionally, you know, we work with a lot of pain management specialists, and, uh, there's one quarter of the population has a predisposition to opioid, uh, dependence. So we're giving people opioids without understanding that by giving them the opioid, you can actually turn on the expression of the genetic predisposition and get them to be dependent. Not everybody. But if there's four of us on this, if we all take an oxy. One of us may actually get triggered that, uh, that dependence gene. So these are the things that we have to be extremely aware of as, as us, as patients or as humans and working with our health care professionals. It has to be a more of a collaborative kind of approach to health and wellness, I understand. Yeah. Thank you. Thank you for shooting. Yeah. So, uh, I'll come to, uh, Michael again. So, uh, for the power of solitude, if you can describe the impact of it. And, uh, also like disconnecting from the stress of the everyday life, uh, on your mental health. So, uh, if you can share and also, like, how can others incorporate this into their own lives? So when you bring up the word disconnection, I have a very, very strong relationship with that word because it's a trait that I have, and I really rely on the idea of disconnecting and it brought me into the wilderness is something we all do. Now, a part of that that we all face is like the fear of sitting alone with ourselves. We bring the mindful aspect of that out here with you. It almost makes it a little bit more comfortable because you're relying on the power of observation, which is something that we all utilize in our everyday life. And you're able to observe the animals, plants, trees and the way that they move and what it does for me and what I like to point out, the people that I work with is it gives you an opportunity to step away from that story of self suffering that we all tell ourselves that we all caught up in, because it's easy and just watch the environment, watch how things move and how they interact with each other. You can build a new story around which team to correct the story that's holding you back. So it helps you to bring this ability to sit with yourself and connect emotionally and inside while engaging the living world around you and removing that disconnect to build a new narrative and a new story that helps you to get and achieve the goals in it. You know, I think it really builds on the clinical aspect of things, because we essentially work hand in hand and whether we're in the clinical. From the outdoor side. We're still working with that collaborative property, you know, vibrating with the person that's guiding us one or the other or the environment around us. But it all comes back to the fact that we got to believe. We got to believe that the steps and the effort that we're putting into whatever avenue we're pursuing is going to achieve that goal. You know, we talk about the medications and this and that. Well, if we rely fully on somebody to give us an answer, it's not going to be a long term fix. So by bringing these mindful practices in to a nature background, you know, peaceful tranquility setting like this. You're able to speak and listen to that voice of hope inside of you. Okay. Got it. Understood. So, um. Okay, I'll come to Dave. Uh, like, what was the turning point that shifted your control over the bipolar disorder? And, uh, how do you guide others to find their own moments of the transformation through the stand up comedy? For me. You know, manic depression, bipolar disorder is cyclical. So I would go into depressive episodes. And as I got older, the depression, the episodes got deeper and deeper, darker and darker and lasted longer. And the same thing with the mania. It it it, uh, I the fly among the clouds, I'd get higher. I had to think I was the smartest person in the room. And, uh, you know, uh, oftentimes I was I was an asshole. Uh, without planning it, without knowing it. It's just how it came out. And so, uh, through I think what I hear, too, from from Lana and Mike is, you know, for me, taking quiet time, I don't necessarily call a meditation. uh, because meditation for me means I've got to get somewhere to, uh, that quiet place where I really don't have any thoughts or they're minimal. And with bipolar disorder, the anxiety is constant and it's always there. And our minds are racing and loops of negative thoughts that are constant. And so the quiet time gave some reprieve for that. And what would happen would be the things that were important would just bubble up in my head. And I knew, you know, maybe it's two things or three things. Um, but oftentimes, um. One thing. If I could accomplish one thing, um, that was success. And I found I was making lists of, uh, lists of things to do, the things that I wanted to do, things that needed to be done. And I could, uh, it was overwhelming and, uh, created anxiety and worse than the depression or the mania. And when I started making lists of one thing or two things or three things, then I could have success by doing just that one thing, and I could mark it off my list and feel good about it. And then that encouraged me to do the other. As far as a turning point, um, part of it was writing my blogging. I blog for BP, hope.com, and my blog posts have been read by over a million people, and the most comment common comment from them was OMG that's me, you're telling my story and I was writing it. When I was writing it, I was actually telling my story and I was helping other people, but I was also helping myself and and I could see it. So the combination of that and then being able to start looking for the humor in my experiences and, uh. You know those? Those were the things that that started me in a different direction. Also, I've got to say medication helped the medication. You know, you don't you don't, uh, you get cured from having bipolar disorder or depression or anxiety, but the medications I'm making can make it so the the lows aren't quite so low and they don't last quite so long. And the, the high is don't go quite so high and they don't last too long. Uh, but again the anxiety was the worst. And you know, just getting out of my own head, whatever, you know, I was stuck. We were stuck. When we're doing that in our own heads, and we have senses of dread and senses of guilt, and it's just constant. So being able to get out of my head, uh, was just and it was, it was just a little bit at a time, but it was a blessing and helped turn, start to turn things around for me. Um. Sort of minister. So can I jump in there real quick to something that was very important to me. It was the assumption of meditation that you had. You know, it was always had to go somewhere. When I got into meditation, I had the same kind of view as caught in the stigmas of it. Like, you know, you got to shave your head. You got one of those 1998, uh, chant CDs or whatever the case may be. I had to talk therapy session where it was introduced to me. I thought it just like that. Just like you were talking about. And then I went out back and I picked up my crossbow and I started shooting, and I realized that all the different things in meditation that are important the breathing, the slowing your thoughts down to being able to center yourself were a part of my my enjoyment, my shooting. So then I started to be able to transition that into coming out in the wilderness. But what I'm looking at is the fact that we all, in one form or another, have, within our daily processes and our daily routines, some form of meditation, which it doesn't necessarily have to go to a certain spot or a certain destination. It's about the journey, the thought process, just like you were talking about writing things down, how you work through them. That's the that's essentially what meditation is about. It's not about chasing a thought or a direction or even technically sitting still. Nine times out of ten, when I'm out in the wilderness with a group, we're walking. We're focusing on walking meditation. It's simply about channeling your thoughts and being able to look at them, to slow down and bring yourself back into the present moment so that everything else is beating down on you. All that stress disorder and, you know, just disruptions are not what you're focused on. You're focusing on you and how you can overcome each of those. And. It's a staircase essentially in front of you to climb and reach each one of those objectives that you write down on the paper. Yeah. And if I may, I like what you said. And if I sit down and I'm going to meditate and I have a purpose for that, I'm going to work on this aspect of what's going on in my life. It doesn't work when I sit down and just be Then again, uh, I calm and the thoughts bubble up, and then that's that's where I end up at it. Not. Not trying to get somewhere, just allowing my mind to to, uh, help me discover, uh, a pathway. Uh, you know, it's right for me. Absolutely. There's always a unique pathway and a unique, you know, individualized journey. If I was to make any suggestion as to, you know, help you kind of tame that or change that in a different direction at some point, if you were comfortable with it would be the idea of walking meditation. Just simply go out for a walk and kind of focusing on inside of your breathing and setting up the actual movements that you're making, the way that it feels when your foot is the ground, the way. You feel the push against you, or it's within your arms and things like that. And ultimately it aimed at kind of softening all that tension that you're bringing to the table when you try to sit down. Because to me, I get a feeling that there's a lot of the hamster wheel momentum going on within the thought process, and your hand is your outlet in writing it down. If you added another tool into it by being in this walking meditation, I feel like it may kind of summarize things for you a little bit and kind of help you to ease into some of these ideas that we're trying to work through. Thanks for that. Well, it's definitely. A great. So, uh, it is a great discussion, I would say. And also I'll quickly come to Len. Uh, so, uh, so, Len, like what? According to you, I mean, uh, I do the, uh, uh, cannabinoids and, uh, interact with the, uh, uh, endocannabinoid system. Like, what role do they play in managing the mental health and the wellness? Um. I'm going to try to see if I can integrate the answer with some of the things that both, uh, Dave, Mike said, uh, when I was a kid, I was, uh, I would sit in class and the teacher would call my brain. I would have different thoughts. Uh, so it was the daydreaming kind of kid. And at some point I was diagnosed with the attention deficit disorder, which I never thought it was a disorder. I always thought it was my superpower, but they labeled it a disorder. So, as Dave said, you know, for some people, medication works. For other people, it doesn't work as well. You got to find the right one. So I was put on prescription medication. I can't say it didn't work. The goal of it was to help me focus, which it did, but it removed my connection to self. So I had no connection to my emotional sense. And uh, by meeting some older kids, they asked me if I wanted to smoke a cigarette. They actually try to, uh, you know, fool me and put cannabis in the cigarette. So I had an experience with cannabis. I went back to class and the windows are open in my head, narrowed, and I could focus. I never said anything to anybody because cannabis wasn't really supposed to be medicine. It's a drug, you know, uh, at that time. But for me, it became my medicine. So I got off the prescription medications. And I'm not advocating this for anybody. This is my experience. And, uh, you know, and I can relate to what Dave was saying about, you know, your mind is trying to escape in many different things. There's all these thoughts because I have this ad and, uh, you know, meditation for me. I want to take so many different classes. I took transcendental Meditation, all those things. But as Mike was saying, the best time that I quote unquote meditate is when I hike in nature. Stop thinking and I just be. And all those kind of things, uh, start flowing in and your your mind gets clarity. You become a vessel for things to start downloading to you. And now your ideas are much more clear. So there's different ways to meditate. I agree with Mike and nature's huge help with that. But so to go back to answer your question about mental health and anxiety and all that stuff, I think it's important for us to establish what the endocannabinoid system really is and how it works, and then how cannabis sort of interacts with that. We discovered this system in 1992. It's it wasn't that long ago, uh, and it evolved with us. There's a lot of things in our bodies that, you know, through evolution, we no longer use and need. But this system evolved with us. So the main goal of the endocannabinoid system is to maintain balance or homeostasis. The way that it does this, it gets signals from the other systems. So like your immune system, your endocrine system, etc., it sends up the central nervous system, sort of like salmon swimming upstream to your brain. And your brain makes a decision which neurochemicals to be able to secrete to get that system back in balance. So the two that are endogenous means we create those ourselves. Uh, part of the endocannabinoid system are called anandamide. And the word and the second one is two AG. So the word uh, Ananda means bliss and Sanskrit is your bliss. Uh, molecule. This is what secreted. This is when we when we run, uh, we get the runner's high. This is one of the chemicals that we produce that gets, uh, made. So when we consume cannabis, the main the two main cannabinoids. Phyto cannabis means the plant is delivering that. Uh, it's called THC delta nine, THC, uh, or and CBD, cannabidiol CBD. So when the plant grows, uh, and you remove that, uh, that bud from plant, it has an acid molecule to it when you heat it. Uh, it's called decrease oscillation. It drops the acid molecule and it binds to our receptors there in our body. So we have CB1 receptors. They're mostly located in our brain and central nervous system. When we consume THC, it binds to your CB1 receptor and releases anandamide. So that's the way the drug works. When we, uh, consume CBD, it has an affinity for the CB2 receptors, which are mostly located in our immune or digestive system or body, and it releases to AG. So those are the two chemicals, neurochemicals that are released that a lion which is cannabis, uh, helps to secrete. Now going back and answering your question about mental health, etc., so let's say. I'll use Mike as an example, but he seems to be a guy that doesn't get rattled really fast, but I'll use him as an example anyway. So Mike is walking down the street and a car flies out of almost nowhere and almost hits him and he's going to have a fight or flight experience. So some of the things are going to happen is you're going to have a secretion of, uh, neurochemicals dopamine, adrenaline, norepinephrine, cortisol. Now, when he realizes his mind realizes it's safe, there's no line chasing you in the jungle. There's two things that happen. There's the reuptake of those neurochemicals, and then your brain releases new neurochemicals to get you back to balance and homeostasis. And those are anandamide and to AG. So your genetics how they would play a role in that. Let's say that Mike has a predisposition to, uh, stress reactivity. And I know that Dave does this. Why? I want to use him as an example, because he already is diagnosed. Let's say he has a predisposition of stress reactivity. It's a gene called, uh, FH five fatty acid amide hydrolase. Very, very important gene. But we may not know because it breaks down anandamide which is that endogenous endocannabinoids. So if he's breaking down anandamide at a very rapid pace compared to the average person, that cortisol that's in his bloodstream can stay longer. And if the cortisol is staying longer in his bloodstream, there's several things that can happen. Number one, it can lower his pH level, make him more acidic. Your immune system can then over respond to that and create inflammation. So what you may feel is inflammation in your knees anywhere in your joints, knees, hips, elbows, neck, back, etc. if he has predisposition to gut health issues, it can actually turn on the expression of IBD or other gut health challenges. The good news is, by understanding this, you can subsidize what you're naturally deficient in. So maybe take some THC, it'll bind to that receptor and I'll actually squirt more anandamide. On the flip side, if you take a little bit too much THC, it does the opposite. It can actually trigger the stress reactivity, make people feel more anxious. And then if he has a gene for PTSD now can replay that over and over and over. And instead of having a therapeutic benefit, you're actually creating an adverse event. So being able to know this about yourself and take the right amount. So a suggestion would be maybe take higher CBD, less THC. And then to answer your other question. Terpenes are essential oils that the plants produce. Every plant produces essential oils in nature. In cannabis, there's two things. The terpenes give it its smell and also have an effect. So if you're prone to stress reactivity, you may want to turn in profile first. That is calming. So something like Lidl, which is also found in lavender, is a common terpene. The second 1st May be beta carotene, which is found in clove and black pepper, and also in some cannabis varieties, and that is an anti-inflammatory. Works very well with CBD to reduce inflammation. So as you're using THC as an example to reduce the pain, you have your your sort of formulation that is geared directly to you. And then you can find the products that are more identified to you. And two other things really, really quick. This one is metabolic function of dosing. How you dose anything is really important because how you metabolize things are different. The doctor tells you to take two of these. Well why am I taking two? Why am I not taking four? Why is Mike not taking one? He may be a slow metabolism, so understanding how to dose correctly is really important. And the last thing is interactions. So we're taking phyto cannabinoids and we're also taking an SSRI like Davis taking medication. There could be an interaction because at that medication uses the same enzymatic pathway one that can be an inducer, one can be an inhibitor. So you got to look at all these different things to be able to guide people to more personalized experience with anything in especially, you know, uh, fighter cannabinoids like, uh, you know, THC and CBD. Wow. Great way of, uh, explaining. Yeah. Thank you. Thank you so much. And it's really, uh, really helpful. Yeah, sure. So, uh, uh, before, I mean, before we wrap. So I'll quickly introduce, I mean, not introduce, I mean, quickly, uh, I want to ask, uh, one advice for the listeners. Uh, what would it be? So anyone, anyone want to start? Um. I'll start. I think, uh, a couple things is when we are in that anxiety state or that depressive state, we, we, you know, we we're we're oftentimes unable to move or do things and, and go out and interact with people. And uh, I know for me, when that was happening, I, um, I ended up going to the mailbox at night, so I didn't see anybody. Um, but I, I think seeing. You know, and knowing that that these things are going on and having a plan for if we're going to be out and interacting with people, have a plan for, um, what are some topics to talk about? And also to, to make sure that we don't just vomit everything about our personal self that, uh, is, you know, it's important to us and that's what's happening with us. But it's it's it's outputting to somebody else. So, uh, there's two things. Uh, uh, smile, ask and listen. And when we smile and say in our mind that about the person we're talking to, if we say, I love you or I like you, our eyes brighten and a smile comes to our face. And then we ask a question and listen carefully. And, uh uh, that makes a huge difference. And then the other one is an acronym that that I talk to, the folks I work with, with mental illness. And the acronym is wait, wait. And it stands for why am I talking? And knowing why you're talking is good. Because usually oftentimes when we're talking, we're we're talking about ourselves. And once we're talking about ourselves, we're still in our head. We're seeking we're seeking acceptance. We're we're trying, you know, we're trying to be okay and show people or take care. We're pretending. And, um, um, you know, we don't have to pretend if we smile, ask and listen. And if we have an idea when we're going into an event, some of the questions we're going to be asking and we're prepared, then that helps us, uh, you know, again, get a get out of our head and, uh, be aware of the surroundings. And, uh, people like to talk about themselves. So the more we ask and the more we listen, the more people like us, uh, we can go home And we. Instead of saying, I wish I hadn't said that, I'm embarrassed about saying this. Uh, we can go home feeling good that we talk to somebody, we learn from somebody. And, um, you know, that gives us peace of mind. And peace of mind is everything when you're living with, uh, depression, anxiety and mania. Uh, peace of mind is is everything, whether it be whether you get it from walking, meditation or, um, one of my favorite things to do is go to Oregon wine country and sit on the deck and overlook the vineyards and have a small glass of wine. And my mind just, you know, just goes and it's it's it's amazing. Lovely. Great. Thank you. Uh, so, Mike, you want to share? So I think actually I would probably start by raising a very, very valid question that comes to mind. Why are we repressing or fighting who we are and starting to embrace, befriend and grow the experience of who we are? Because, you know, I've come from much different backgrounds, but all three of us are on the exact same mission. What makes that mission look and feel and sound different? The labels and the terminology. If any one of us connected on the street somewhere and we started up conversation, that conversation would flow great. But because we're in this arena right now, we're having these little bit of hiccups back and forth because the stigmas, they are what we stick that fear behind. So if we take time to not only learn about ourselves and embrace their selves, find their voice. And then open our ears and allow for next to us to do this. And we would answer so many more questions, so much quicker, and we would provide so much great help for the people that we're trying to serve. Because I've seen ideas, I've heard points and thoughts in this conversation that I've never thought of from that perspective. But now when I take back and apply them to the story I have sends up a new door. You know, I'm sitting here at a campfire right now sharing stories and ideas that may sound completely different to somebody else, but when they apply them to their to the context of the world they live, it still provides it the same motivation. And I think whether it's in the arena of trying to help someone or just to own personal lives, removing those layers, realizing that we all have a place within the circle, that even is the step that needs to be taken. Okay. Okay. So, Len. Well, I have to agree with my colleagues on here. And Mike said something really profound. Knowing yourself is key. And 99.9% of our genetics is the same. We are all the same. It's that 0.1% that really makes us different. And once we understand those nuances, we can connect with love and kindness with our fellow human on a path that is similar. Instead of focusing on that 0.1%, that makes us different when we're looking to treat ourselves health and wellness wise. We have to understand that that 0.1% nuance is also what can make us different in terms of treatment. So we're not going to be treated exactly the same way all the time with our health and wellness, whether it's mental or physical health. So the thing that I want to express to people is really learn yourself as much as possible, do as much diagnostic work on yourself as possible. Look at your genetics. Look at your epigenetic expression. Look at your gut microbiome. Understand all these things and then actually treat yourself first with love and kindness. Understand that you may have these predispositions, but you are empowered to actually make lifestyle changes according to that. And it's not a sentence. Just because you have something genetically predisposed to it doesn't mean that you're not empowered to make changes. But the more you learn about yourself, the better you can collaborate with people, your health care professionals and yourself. Love and kindness. Exactly, exactly. Lovely. Great, great. Thank you. Thank you so much, everyone, for joining us on this episode of Healthy Waves. And I hope that the listeners, like our discussions today, have provided you with the valuable insights and the inspiration to harness the power, um, of your mind in overcoming the addiction, trauma, chronic illness. So, uh, and definitely a huge, uh, thank you to our amazing guests. Uh, they've Mike Len, uh, for sharing, um, uh, their stories and the expertise with us and for the listeners, I would love to mention, like always remember that, uh, no matter how the turf journey is, there is always a hope. And, uh, there is a way to find light in the darkness. So stay tuned, uh, for more expert discussions on our next episode. And until then, take care and stay healthy. So thank you so much. Thank you. Thank you. Great.

Join Mike and Kenny as we break down position battles, early pressers and Maxx Crosby being that guy. Jack Jones is ready for CB1 and Christian Wilkins is as good as advertised. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Arizona Cardinals TE Trey McBride was on Adam Schefter's podcast and raved about Marvin Harrison Jr. living up to the hype and being an elite freak of nature. Can Kyler Murray regain his MVP style of play during the 2024 NFL season? Will Jonathan Gannon find his CB1 in Max Melton? Join Johnny Venerable, Bo Brack and Damon Dawg on Tuesday's PHNX Cardinals Podcast! 0:00 Intro 1:30 Trey McBride's comments on Marvin Harrison Jr. 31:45 Paris Johnson Jr. speaks to the media 36:00 PJJ on shifting to left tackle position An ALLCITY Network Production SUBSCRIBE to our YouTube: https://bit.ly/phnx_youtube ALL THINGS PHNX: http://linktr.ee/phnxsports PHNX Events: Get your tickets to PHNX events and takeovers here: https://gophnx.com/events/ bet365: https://www.bet365.com/olp/open-account?affiliate=365_03330244 Use the code PHNX365 to sign up, deposit $10 and choose between either: Bet and Get offer and place a bet of $5 or more and get $150 in Bonus Bets OR First Bet Safety Net offer by placing a bet up to $1000 and if your qualifying bet loses you receive a matched refund in Bonus bets Disclaimer: Must be 21+ and physically located in AZ. If you or someone you know has a gambling problem and wants help, call 1-800-NEXT-STEP, text NEXTSTEP to 53342 or visit https://problemgambling.az.gov/ Indeed: listeners of this show will get a $75 SPONSORED JOB CREDIT to get your jobs more visibility at https://indeed.com/allcity. Terms and conditions apply. Need to hire? You need Indeed. Desert Financial Credit Union: Open a free checking account online with Desert Financial Credit Union and get an Arizona Cardinals VISA ® Debit Card https://www.desertfinancial.com/cardinals Gametime: Download the Gametime app, create an account, and use code PHNX for $20 off your first purchase. Terms apply. Circle K: Join Inner Circle for free by downloading the Circle K app today! Head to https://www.circlek.com/store-locator to find Circle Ks near you! Four Peaks: Follow them on social @fourpeaksbrew & @fourpeakspub! Must be 21+. Enjoy responsibly. Shady Rays: Exclusively for our listeners, Shady Rays is giving out their best deal of the season. Head to https://shadyrays.com and use code: PHNX for 35% off polarized sunglasses. Try for yourself the shades rated 5 stars by over 300,000 people. TrueFan Travel: For PHNX Cardinals Road Trip to Miami, Head to https://truefantravel.com/trips/ to book your spot today! Chicken N Pickle: Head to https://chickennpickle.com to see all the fun you can have at their Glendale location! PHNX will be hosting Trivia Nights and Pickleball Tournaments so stay tuned for info! When you shop through links in the description, we may earn affiliate commissions. Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Punit Dhillon, Chairman and CEO of Skye Bioscience, focuses on anti-obesity and developing a drug that targets the cannabinoid receptor 1, which plays a role in signaling the body to store fat. The next generation of CB1 inhibition moves from a centrally mediated pathway to targeting CB1 receptors outside the brain. Deploying the endocannabinoid system, their lead drug candidate targets the major organs where CB1 receptors reside in fat tissue to increase mitochondrial activity and burn more fat.  Punit explains, "Skye is focused on exploring research modulating different therapeutic targets via the endocannabinoid system. Our research has narrowed in on the CB1 receptor, where we're modulating it by focusing on this pathway of inhibition. There's a big body of evidence, actually existing validation of this cannabinoid receptor 1 being a really important target to reduce caloric food intake and increase energy expenditure. It's been a really important target for weight loss because of its particular relevance in that therapeutic area. So we're advancing in a very interesting clinical pipeline and immediately a Phase 2 study that will look at that particular target. We hope that we will be able to show its relevance in the anti-obesity medication landscape." "I feel like the current landscape of drugs that have been getting the most attention has been focused on caloric restriction. Weight loss is driven by that particular pathway of restricting the amount you eat. We are trying to shift that paradigm to the opportunity to address the underlying issues relating to weight loss so you can essentially have this aspect of targeting fat and being able to address fat metabolism. That comes back to this link to the exercise comment you made because it's driving the underlying mitochondrial activity, which is helping to improve the thermogenesis and the conversion of that fat into thermogenic energy."  #SkyeBioscience #Obesity #EndocannabinoidSystem #WeightLossDrug #CB1Receptor #GLP1 skyebioscience.com Download the transcript here

Punit Dhillon, Chairman and CEO of Skye Bioscience, focuses on anti-obesity and developing a drug that targets the cannabinoid receptor 1, which plays a role in signaling the body to store fat. The next generation of CB1 inhibition moves from a centrally mediated pathway to targeting CB1 receptors outside the brain. Deploying the endocannabinoid system, their lead drug candidate targets the major organs where CB1 receptors reside in fat tissue to increase mitochondrial activity and burn more fat.  Punit explains, "Skye is focused on exploring research modulating different therapeutic targets via the endocannabinoid system. Our research has narrowed in on the CB1 receptor, where we're modulating it by focusing on this pathway of inhibition. There's a big body of evidence, actually existing validation of this cannabinoid receptor 1 being a really important target to reduce caloric food intake and increase energy expenditure. It's been a really important target for weight loss because of its particular relevance in that therapeutic area. So we're advancing in a very interesting clinical pipeline and immediately a Phase 2 study that will look at that particular target. We hope that we will be able to show its relevance in the anti-obesity medication landscape." "I feel like the current landscape of drugs that have been getting the most attention has been focused on caloric restriction. Weight loss is driven by that particular pathway of restricting the amount you eat. We are trying to shift that paradigm to the opportunity to address the underlying issues relating to weight loss so you can essentially have this aspect of targeting fat and being able to address fat metabolism. That comes back to this link to the exercise comment you made because it's driving the underlying mitochondrial activity, which is helping to improve the thermogenesis and the conversion of that fat into thermogenic energy."  #SkyeBioscience #Obesity #EndocannabinoidSystem #WeightLossDrug #CB1Receptor #GLP1 skyebioscience.com Listen to the podcast here

Nick Kendell discusses ESPN's Jeff Legwold's recent article discussing Denver and their Cornerback Two Spot. With Patrick Surtain II and Ja'Quan McMillian starting at CB1 and nickel, who will rise up and take the final starting cornerback spot? Can Mathis step up and make up for last year's faltering? Will Moss be healthy and show why Denver traded up for him two drafts ago? Will the veteran Levi Wallace provide steady play? Will darkhorse rookie Kris Abrams-Draine be a surprising starter? Subscribe to Mile High Huddle Podcasts: https://www.bluewirepods.com/podcast/mile-high-huddle Nick Kendell: https://twitter.com/NickKendellMHH Scott Kennedy: https://www.youtube.com/c/scottkennedy?sub_confirmation=1 Merch: http://mhhmerch.com/ Slam it here for more Broncos coverage: http://milehighhuddle.com Mile High Huddle Live Stream Schedule (All Times MT) Sunday - 6:00 p.m. Mile High Huddle Podcast Monday - 7:30 a.m. Broncos for Breakfast Monday - 6:00 p.m. Mile High Huddle Podcast Tuesday - 6:00 p.m. Building the Broncos Wednesday - 7:30 a.m. Broncos for Breakfast Wednesday - 6:00 p.m. Mile High Insiders Thursday - 6:00 p.m. Mile High Huddle Podcast Friday - 6:00 p.m. Dove Valley Deep Divers Saturday - 6:00 p.m. Orange and Blue View Learn more about your ad choices. Visit podcastchoices.com/adchoices

Matt continues his series on the impact of cannabis, THC, and CBD upon sleep this week with an examination into the intricacies of cannabidiol (CBD), which, unlike its psychoactive counterpart THC, does not induce a high but is recognized for its potential therapeutic effects. While studies suggest that CBD may aid in alleviating anxiety, movement disorders, pain, and addiction, in this episode, our host focuses on exploring CBD's potential influence on sleep quality while examining its biochemistry and neurobiology.Matt explains that CBD modulates the body's endocannabinoid system without directly binding to cannabinoid receptors like CB1 and CB2, which THC targets. Instead, CBD enhances the activity of natural endocannabinoids, extending their effectiveness. This modulation can promote sleep by increasing deep non-REM sleep, as demonstrated in both animal and human studies. Despite these promising results, Matt emphasizes that the effects of CBD on sleep are complex and dose-dependent, with higher doses showing potential benefits. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.Are sleep troubles keeping you up at night? Matt used to be a skeptic about meditation, but 7 years ago, he tried it using a fantastic meditation app called ‘Calm', and it transformed his sleep! Now, he meditates for 10 minutes before bedtime every night! He's also partnered with Calm who have been generous enough to offer his podcast listeners an exclusive 40% discount on their premium subscription! All you have to do is go to calm.com/mattwalker and take advantage of this incredible deal! Head on over now and improve your sleep today!The good people at InsideTracker are one of the sponsors of this week's episode, and they are generously offering a special 25% off any one of their programs for anyone who uses the above link during the time window of this episode. InsideTracker is a personalized biometric platform that analyzes your blood and your DNA to better understand what's happening inside of you.Another exciting sponsor is Levels, the groundbreaking continuous glucose monitor that keeps track of your blood sugar levels day and night. Whether you're curious about your body's response to different foods or seeking to enhance your sleep quality, Levels has the answers. If you're interested, visit levels.link/Mattwalker now to grab an exclusive podcast offer of two free months of this impactful service, and take charge of your health journey today!As always, if you have thoughts or feedback you'd like to share, please reach out to Matt on Instagram.

How does CBD affect the CB1 receptor, really? Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD's allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing […]

Who are the 10 most important, valuable pieces to the Philadelphia Eagles success in 2024? Are the MVPs mostly on the offensive side of the ball? What about the coaches and coordinators? Which defensive players will step up and be game-changers? Will Jalen Carter be the MVP of the defense? Is Quinyon Mitchell going to get CB1 responsibilities from the jump? Are Kellen Moore and Vic Fangio more important to the Eagles success this year than Nick Sirianni? How crucial will it be for Cam Jurgens to successfully replace Jason Kelce in 2024?  Support Us By Supporting Our Sponsors!Monopoly GO!Game off! We gotta talk more about MONOPOLY GO! This fast paced game let'syou team up with friends for tournaments to unlock awesome prizes like,Unique stickers for trading,- Cool playing pieces,- And hilarious emojis for taunting your friends. So download MONOPOLY GO! now free on Google Play or the App store.Game on!Yahoo FinanceFor comprehensive financial news and analysis, visit the brand behind every great investor. Yahoofinance.comeBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotors.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Terms Apply. FanDuelFanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning GUARANTEED That's A HUNDRED AND FIFTY BUCKS – with any winning FIVE DOLLAR BET! Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

Did you know that 1 in 5 Americans have tried marijuana at least once in their life? It is the most commonly used recreational drug in the U.S. but many do not realize how it impacts fertility, success with IVF, miscarriage risk, and pregnancy health.  It's easy to assume that something that is legal medically and sometimes recreationally in many states could be harmful to your health, especially your reproductive health.   If you've been curious about marijuana use and fertility - this episode is a valuable resource full of studies on cannabis use on female and male fertility, time to pregnancy, menstrual cycles, IVF outcomes, and pregnancy risks.  In this episode you'll hear: [0:59] Marijuana use in the U.S - both recreational & medical [2:19] Facts about cannabis - THC and CBD Risks to general health Risks to reproductive health [4:17] Let's review the evidence: Male fertility & marijuana [9:13] Let's review the evidence: Female fertility & marijuana [13:03] Recap and suggestions for next steps Resources mentioned:  Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men pubmed.ncbi.nlm.nih.gov26283092 Modifiable and non-modifiable risk factors for poor sperm morphology (regular marijuana use associated with poor sperm morphology) pubmed.ncbi.nlm.nih.gov/24899128 Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro. pubmed.ncbi.nlm.nih.gov/16500334 Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function hpubmed.ncbi.nlm.nih.gov/15562018 A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/16458631 Male Preconception Marijuana Use and Spontaneous Abortion: A Prospective Cohort Study pubmed.ncbi.nlm.nih.gov/33165011 Impact of Tobacco and Marijuana on Infertility and Early Reproductive Wastage pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/35125388 Cannabis use while trying to conceive: a prospective cohort study evaluating associations with fecundability, live birth and pregnancy loss pubmed.ncbi.nlm.nih.gov/33421071 Marijuana smoking and outcomes of infertility treatment with assisted reproductive technologies pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/31505640 A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/16458631 Cannabis use during pregnancy and postpartum pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/32060189 Stay Up to Date in Fertility News and Events:  Weekly Newsletter Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books

Philadelphia Eagles general manager Howie Roseman HAS to invest draft picks next week into the defensive side of the football. Who are the prospects that Louie and Gino want the most at every position? Is Quinyon Mitchell the obvious CB1 and trade-up target for the Eagles? Who are the Day 2/3 sleepers the guys want? Just how good could Texas A&M LB Edgerrin Cooper be in Vic Fangio's defense with his speed and length? Would the Eagles be smart to take UNC LB Cedric Gray over Clemson LB Jeremiah Trotter Jr.? Is Florida State the go-to spot for defensive lineman this year? Support Us By Supporting Our Sponsors!Monopoly GO!Get in the game and join your friends. Download MONOPOLY GO! now free on The App Store or Google Pay. The mobile hit twist on classic MONOPOLY.Yahoo FinanceFor comprehensive financial news and analysis, visit the brand behind every great investor, YahooFinance.com.eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.LinkedInLinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase.FanDuelFanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning GUARENTEED That's A HUNDRED AND FIFTY BUCKS – win or lose! Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) 

@00:14 Intro @01:20 Rock is very good at man coverage, especially versus big, possession type receivers. @03:29 He never had a chance in Baltimore to get comfortable with the defense around him. @05:30 After being traded to the Raiders, he had a solid season, then bet on himself in Free Agency. @07:25 His last season with the Indianapolis Colts, he was a CB1, and played like it. @09:40 Ya-Sin's lock down ability will help the 49ers defense get to the Quarterback even more!  

The NFL Draft is just weeks away and cornerback Cooper DeJean looks to show off his athleticism at Iowa's Pro Day next week. But with that being said, who is CB1 of this NFL Draft class? Chris Carter and James Rapien compare and contrast DeJean with Quinyon Mitchell, Terrion Arnold and Nate Wiggins among the top cornerback options coming out of the draft. Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase.FanDuelNew customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) 

Nate Wiggins, Quinyon Mitchell, and a few others are in contention for CB1 of the class. DP and Keith break down the CB class into three tiers, CB1s, CB2s & the best nickel/slot CBs. Who will land in which tier? Tune in to find outSupport Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer. BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month. GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelNew customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)  

Today, I am blessed to have here with me Dr Lee Know. He is a licensed naturopathic doctor and Cannanda's co-founder and Managing Director. This company manufactures Natural Health Products to assist people and animals in living long and happy lives. Dr Lee has always been interested in health and medicine. He thought that, just like others, he would go to a conventional medical school. However, he truly desires to study nutrition, botanical medicine, and all other types of traditional medicine. The problem is that he doesn't know the path towards it. Moving forward, Dr Lee met a person who introduced him the naturopathic medicine. Since then, he has continued to study the field of medicine he is interested in. Dr Lee Know is also the author of Mitochondria and the Future of Medicine: The Key to Understanding Disease, Chronic Illness, Aging, and Life Itself. This book dives deeper into the scientific understanding of what mitochondria is and how it affects medicine in the future. In this episode, Dr Lee discusses how mitochondria and the ketogenic diet are linked. He also shares tips on how to take care of our mitochondria. Dr. Lee shares his journey in building his company, Cannanda. Aside from that, he talks about what Endocannabinoid System is. Furthermore, Dr Lee tells the difference between THC and CBD and how to ease a dog's anxiety using one of their top-selling products. Tune in as we chat about the mitochondria, ketogenic diet, endocannabinoid system, cannabis, and his company, Cannanda.   Get Cannanda products here (coupon code applied) https://www.cannanda.com/KETOKAMP Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  ⭐ Bioptimizers Magnesium Breakthrough. Get the best night of sleep ever. NO OTHER supplement on the market offers 7 types of magnesium in 1 bottle. Visit bioptimizers.com/ketokamp  and use promo code ketokamp10 for 10% off your first order.  ⭐ Upgraded Formulas | http://www.upgradedformulas.com Purchase Upgraded Formulas, Charge Electrolytes, and other products. GET 15% OFF with Coupon Code: KETOSIS Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [8:30] How Does Mitochondria and Ketogenic Diet Relate To Each Other? Mitochondria is very heavily involved in the ketogenic diet, or the benefits of the ketogenic diet really heavily weigh on the mitochondria. There is a strong link between the benefits of the ketogenic diet and how it improves the functioning of the mitochondria. There are incredible success stories of people with Alzheimer's improving their condition by going on a ketogenic diet. Studies on the ketogenic diet and calorie restriction found that you can reverse type two diabetes.  [18:15] Are Worried About Your Mitochondria? Get Physically Active and Take Care of It! A sedentary lifestyle has a huge negative impact on the mitochondria Being physically active is the greatest thing you can do for your mitochondria. You need to ensure that you feed your body with the nutrients it needs, but not in the way you introduce excessive calories.  The more mitochondria you have, the better everything else works. [27:46] Dr Lee's Excellent Journey in Building His Company, Cannanda Dr Lee has always been interested in studying the Endocannabinoid system's influence on health. The endocannabinoid system and the mitochondria are both related to homeostasis. Anytime something goes wrong in the body, the endocannabinoid system's job is to jump into action and start the processes needed to bring about healing or bring those processes back towards their balanced state.  Medicinal use of cannabis was legalized in Canada, which allowed him to study more, and grew his interest in this field. Dr Lee realizes the need to create a more accessible and economical business for customers to buy. [33:53] How to Activate Endocannabinoid System to Regulate Our Nervous System? The two main components of the Endocannabinoid System are the cannabinoid compounds that our bodies make and the cannabinoid receptors.  Cannabinoid receptors have two main types that are often talked about, and that is cannabinoid receptor type one or CB1, and cannabinoid receptor type two or CB2. When you use cannabis and THC, that activates the CB1 receptors, and that's what gets people high. CB2 brings a lot of health benefits when activated. The difference in CB1 is that you won't be intoxicated. The Endocannabinoid system regulates the nervous system by sending inhibitory signals up the chain. [41:05] THC and CBD: What Is Their Difference and How It Affects The Benefits You Could Get? CBD actually doesn't activate CB1 or CB2 receptors. Unlike THC, which can activate both CB1 and CB2 receptors, when you get CB2 activated from using cannabis, it's actually coming from THC. The best type of product is what they call a full spectrum extract because the full spectrum will have the THC, and that's where the CB2 receptor activation and many of the health benefits will actually come from. Dr Lee's product is a selective CB2 agonist or an activator. And that means it activates CB2 receptors without activating the CB1. Hence, you get all the health or physiological benefits of activating CB2 receptors but none of the intoxications that comes with CB1 activation.  [47:44] Dog Anxiety: How to Safely Use Cannabis to Help Your Dog Every vertebrate mammal has an endocannabinoid system.  Dr Lee has a product called Dog Ease CB2, their top seller on Amazon. Dog Ease CB2 have healthcare approval. People use Dog Ease CB2 for stress-related behavior in dogs, whether it's separation anxiety, thunders, or anything that makes a dog nervous.  Cats also metabolize terpenes at a much slower rate than humans and dogs. The dose given to cats is a fraction of what the dog label says.  AND MUCH MORE! Resources from this episode:  Get Cannanda products here (coupon code applied) https://www.cannanda.com/KETOKAMP Follow Dr Lee Know: LinkedIn: https://www.linkedin.com/in/leeknow/  Twitter: https://twitter.com/leeknow3d?lang=en  Facebook: https://www.facebook.com/CannandaCrew  Instagram: https://www.instagram.com/CannandaCrew/  Dr. Lee Know on Amazon:  https://www.amazon.com/Mitochondria-Future-Medicine-Understanding-Disease/dp/1603587675/benazadi-20  https://www.amazon.ca/CBD-Hemp-Oil-For-Dogs/dp/B08H5ND2J2/benazadi-20  The Documentary mentioned during the episode: https://vimeo.com/ondemand/207515 Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  ⭐ Bioptimizers Magnesium Breakthrough. Get the best night of sleep ever. NO OTHER supplement on the market offers 7 types of magnesium in 1 bottle. Visit bioptimizers.com/ketokamp  and use promo code ketokamp10 for 10% off your first order.  ⭐ Upgraded Formulas | http://www.upgradedformulas.com Purchase Upgraded Formulas, Charge Electrolytes, and other products. GET 15% OFF with Coupon Code: KETOSIS Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. Some links are affiliate links  // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

USC QB Caleb Williams is viewed as a generational prospect and compared to Patrick Mahomes. DP and Keith discuss why that is not true, entirely. What makes Williams great and where can he improve as a player? DP went to Clemson's Pro Day. Did Nate Wiggins do enough to lock down the CB1 title? Ladd McConkey is not your average slot receiver. The guys breakdown why he is an outside receiver and the lazy comps must stop.  Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. NissanOur friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com. RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer. BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month. GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelNew customers, join today and you'll get TWO HUNDRED DOLLARS in BONUS BETS if your first bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)  

Keith drops his latest mock draft after the NFL Scouting Combine. Justin Fields is teamed up with fellow Ohio State Buckeye, WR Marvin Harrison Jr. Who wins the Caleb Williams sweepstakes? Nate Wiggins dominated the 40-yard dash, did this put him as the front-runner for the CB1 crown? Xavier Worthy heads to Philadephia to bring much-needed speed to the Eagles' offense.  Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. NissanOur friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com. RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer. BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month. GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelGet buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)  

The Chargers roster needs major improvements making a move to trade back very likely and they would still have fantastic options available like Terrion Arnold. The Alabama corner would fill a gigantic need for LA because he does almost everything exceptionally well and would give the team a true CB1. Dan and David look at the best options for he Chargers if they trade back in the NFL Draft. Oregon State tackle Taliese Fuaga is another player that makes a ton of sense of the Chargers with a road grading run blocker that fits Greg Roman's scheme. EDGE rusher Dallas Turner is an explosive option that would give the Los Angeles defense a boost depending on what happens with Joey Bosa and Khalil Mack. Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.NissanOur friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com.RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelGet buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

Cornerbacks, Safeties, and Tight Ends ran the 40-yard dash, tested their vertical and broad jumps, and finished with field drills. Who are the Money Makers from day one of the on-field workouts? Clemson CB Nate Wiggins made his case for CB1 with a strong athletic testing day before he went down with a hip injury. Toledo's Quinyon Mitchell had a dominant day to also make his case for CB1. Who else shined and made themselves money? Which safety tandem fumbled the bag with their unimpressive testing? What is the biggest takeaway regarding the 2024 Tight end class?   Support Us By Supporting Our Sponsors! eBay Motors For parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.   Nissan Our friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com.   BetterHelp This episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.   Gametime Download the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase. FanDuel Get buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started.   FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN)

After a season riddled with injuries and bad play at the cornerback position, the Philadelphia Eagles need to make a splash at the position this offseason. Will general manager Howie Roseman target a top-tier free agent like L'Jarius Sneed to replace James Bradberry and eventually Darius Slay? Will he focus on the draft and trade routes more for the CB1 spot and add a cheaper veteran to compete at CB2? Would a reunion with Steve Nelson make sense?Who could Roseman trade for at CB this offseason? Patrick Surtain? Jaycee Horn? Riq Woolen? Is there a player available we aren't thinking of?Most likely to sign, top preferences, and more on the cornerback addition of offseason options!Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.NissanOur friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.FanDuelGet buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

After a season riddled with injuries and bad play at the cornerback position, the Philadelphia Eagles need to make a splash at the position this offseason. Will general manager Howie Roseman target a top-tier free agent like L'Jarius Sneed to replace James Bradberry and eventually Darius Slay? Will he focus on the draft and trade routes more for the CB1 spot and add a cheaper veteran to compete at CB2? Would a reunion with Steve Nelson make sense? Who could Roseman trade for at CB this offseason? Patrick Surtain? Jaycee Horn? Riq Woolen? Is there a player available we aren't thinking of? Most likely to sign, top preferences, and more on the cornerback addition of offseason options! Support Us By Supporting Our Sponsors! eBay Motors For parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. Nissan Our friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com. BetterHelp This episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month. Gametime Download the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase. FanDuel Get buckets with your first bet on FanDuel, America's Number One Sportsbook. Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR BET! That's A HUNDRED AND FIFTY BUCKS – if your bet wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

The 2024 Reese's Senior Bowl has officially concluded in Mobile, Alabama with many top NFL Draft prospects standing out! What positions from the all-star event should the Philadelphia Eagles be watching the closest based on needs and strength of the class? Locked On NFL host and national draft scout for The Draft Network Damian Parson joins the show to highlight his biggest winners from the week! Did Toledo CB Quinyon Mitchell catapult himself into the CB1 conversation? Are the trenches yet again the focus for the Eagles? Is the offensive line the deepest position in the draft? Parson also dives into Day 2 and Day 3 running back prospects the Eagles could improve their backfield committee with including Kentucky's Ray Davis, what teams should do with giant yet raw prospects in Florida State WR Johnny Wilson and Miami S James Williams, and more! Also: How important is the Senior Bowl, the scouting combine, and other draft events for the evaluation process? How much stock should we put into them? Support Us By Supporting Our Sponsors! eBay Motors For parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. Nissan Our friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com. BetterHelp This episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month. PrizePicks Go to PrizePicks.com/lockedonnfl and use code lockedonnfl for a first deposit match up to $100! Gametime Download the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase. LinkedIn LinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply. Robinhood Robinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer.  FanDuel Make Every Moment More. Right now, NEW customers get TWO HUNDRED DOLLARS in BONUS BETS if your best bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

The 2024 Reese's Senior Bowl has officially concluded in Mobile, Alabama with many top NFL Draft prospects standing out! What positions from the all-star event should the Philadelphia Eagles be watching the closest based on needs and strength of the class? Locked On NFL host and national draft scout for The Draft Network Damian Parson joins the show to highlight his biggest winners from the week! Did Toledo CB Quinyon Mitchell catapult himself into the CB1 conversation? Are the trenches yet again the focus for the Eagles? Is the offensive line the deepest position in the draft?Parson also dives into Day 2 and Day 3 running back prospects the Eagles could improve their backfield committee with including Kentucky's Ray Davis, what teams should do with giant yet raw prospects in Florida State WR Johnny Wilson and Miami S James Williams, and more!Also: How important is the Senior Bowl, the scouting combine, and other draft events for the evaluation process? How much stock should we put into them?Support Us By Supporting Our Sponsors!eBay MotorsFor parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit at eBayMotos.com. Let's ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply.NissanOur friends at Nissan have a lineup of SUV's with the capabilities to take your adventure to the next level. Take the Nissan Rogue, Nissan Pathfinder, or Nissan Armada and go find your next big adventure. Shop NissanUSA.com.BetterHelpThis episode is sponsored by BetterHelp. Make your brain your friend, with BetterHelp. Visit BetterHelp.com/LOCKEDON today to get 10% off your first month.PrizePicksGo to PrizePicks.com/lockedonnfl and use code lockedonnfl for a first deposit match up to $100!GametimeDownload the Gametime app, create an account, and use code LOCKEDON for $20 off your first purchase.LinkedInLinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply.RobinhoodRobinhood has the only IRA that gives you a 3% boost on every dollar you contribute when you subscribe to Robinhood Gold. Now through April 30th, Robinhood is even boosting every single dollar you transfer in from other retirement accounts with a 3% match. Available to U.S. customers in good standing. Robinhood Financial LLC (member SIPC), is a registered broker dealer. FanDuelMake Every Moment More. Right now, NEW customers get TWO HUNDRED DOLLARS in BONUS BETS if your best bet of FIVE DOLLARS or more wins. Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Is Michigan quarterback J.J. McCarthy a better 2024 NFL Draft prospect than Oregon's Bo Nix? The guy tells you why the answer is yes. What are the concerns for McCarthy heading into the Draft season? Bo Nix may be a scheme/situation-specific prospect. Alabama's Kool-aid McKinstry and Clemson's Nate Wiggins battle for the crown of CB1 for the 2024 NFL Draft. Who will DP & Keith choose? The NFL week 16 rookie spotlight is shining brightly on a pair of Carolina Panthers when they face the Green Bay Packers. Support Us By Supporting Our Sponsors!DoorDashGet 50% off up to $10 value when you spend $15 or more on your FIRST order, when you download the DoorDash app and enter code LOCKED23. Subject to change. Terms apply.PrizePicksGo to PrizePicks.com/lockedonnfl and use code lockedonnfl for a first deposit match up to $100!GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Last minute tickets. Lowest Price. Guaranteed.LinkedInLinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply.FanDuelScore early this NFL season with FanDuel, America's Number One Sportsbook! Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR MONEYLINE BET! That's A HUNDRED AND FIFTY BUCKS – if your team wins! Visit FanDuel.com/LOCKEDON to get started.FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Is Michigan quarterback J.J. McCarthy a better 2024 NFL Draft prospect than Oregon's Bo Nix? The guy tells you why the answer is yes. What are the concerns for McCarthy heading into the Draft season? Bo Nix may be a scheme/situation-specific prospect. Alabama's Kool-aid McKinstry and Clemson's Nate Wiggins battle for the crown of CB1 for the 2024 NFL Draft. Who will DP & Keith choose? The NFL week 16 rookie spotlight is shining brightly on a pair of Carolina Panthers when they face the Green Bay Packers.  Support Us By Supporting Our Sponsors! DoorDash Get 50% off up to $10 value when you spend $15 or more on your FIRST order, when you download the DoorDash app and enter code LOCKED23. Subject to change. Terms apply. PrizePicks Go to PrizePicks.com/lockedonnfl and use code lockedonnfl for a first deposit match up to $100! Gametime Download the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Last minute tickets. Lowest Price. Guaranteed. LinkedIn LinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply. FanDuel Score early this NFL season with FanDuel, America's Number One Sportsbook! Right now, NEW customers get ONE HUNDRED AND FIFTY DOLLARS in BONUS BETS with any winning FIVE DOLLAR MONEYLINE BET! That's A HUNDRED AND FIFTY BUCKS – if your team wins! Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices