Podcasts about cb1

The Giants finally have reasons for optimism, but the cost of buying in too early is ignoring the same “ifs” that burned fans before. Jaxson Dart, John Harbaugh, Malik Nabers, Cam Skattebo, Arvell Reese, and Colton Hood all give Giants fans something to watch, but this episode keeps the pressure where it belongs: the team has to prove it.Follow on Spotify and leave a 5-star rating on Apple Podcasts if you enjoy no-BS Giants debate.Can Jaxson Dart and John Harbaugh make the Giants a consistent winner in 2026? They can, but only if Dart takes a real Year 2 step, Harbaugh's practice structure translates into September preparedness, and the roster's biggest “ifs” turn into actual answers.Drew opens with NFL Media's Eric Edholm laying out a possible Giants path back to respectability, and maybe even playoff relevance. The optimism makes sense on paper: Dart had rookie flashes, Nabers and Skattebo could return healthy, the offensive line may be trending upward, and the defense still has real talent up front. But Drew pushes back hard on the number of conditions attached to that hope. The Giants went 1-7 in one-score games last year, the Eagles still own the division, and the secondary still has real questions. The message is simple: optimism is available, but the Giants have to earn it.Is John Harbaugh the one reason this year feels different?The Harbaugh conversation centers on Charlotte Carroll's minicamp takeaway from The Athletic. Longer practices, more situational reps, and a tougher tone already separate this regime from the Brian Daboll era. Drew argues that Harbaugh may be the only reason to feel cautious optimism right now, because the Giants too often looked unprepared early in seasons under the prior staff.The Jaxson Dart section becomes the main quarterback debate. Gary Davenport of Footballguys listed Dart as one of eight players set to explode into stardom in 2026, and the upside is clear: rushing production, early touchdown-drive success, confidence, and a more vocal presence. But the concern is just as clear. Dart's physical style already created concussion worries, and the offense badly needs Malik Nabers to return as a true top weapon. Andrew Thomas' comments about Dart's improved communication matter because he has seen Dart's growth up close, while Isaiah Likely's praise carries weight because he came from a Lamar Jackson-led offense.Are Giants fans putting too much on Arvell Reese too early?Drew and Rob then move into rookie expectations, starting with Arvell Reese. Frank Bush's message was not to turn Reese into someone else or overload him too soon. That led to a bigger debate about unrealistic comparisons, especially the habit of comparing every athletic defensive rookie to Micah Parsons. The hosts agree Reese does not need to become a superstar overnight. A realistic rookie year should be about sound football, being in the right spots, flashing athleticism, and growing into the role.The episode closes with Colton Hood, who may be the rookie the Giants need most. Donald D'Alesio praised Hood's mindset, strength, and fast learning, and Drew explains why the cornerback room makes Hood's development so important. The Giants need more than another rotating cast of replacement-level corners. Hood does not have to become an instant CB1, but if he can become a reliable, physical starter, that would change a lot for this defense.Merch: https://2giantgoofballs-shop.fourthwall.com/Support: https://buymeacoffee.com/2giantgoofballsAll episodes: https://2giantgoofballs.buzzsprout.com/Send us Fan MailSupport the show

MetLife Stadium may still make money, but the latest World Cup pitch complaints raise a bigger problem for Giants fans: is the home field becoming an embarrassment the team cannot ignore? Follow on Spotify and leave a 5-star rating on Apple Podcasts if you enjoy no-BS Giants debate.The Big Question: Is MetLife Stadium a real Giants problem or just an overblown player complaint? The answer is probably both: FIFA may say the field is playable, but when World Cup players, NFL players, and Giants fans all keep circling the same stadium complaints, the issue becomes bigger than one surface.Drew and Rob spend the first half of the show on MetLife after Adrien Rabiot and Vinicius Junior criticized the pitch and FIFA defended the stadium conditions. The conversation quickly moves beyond grass vs. turf into the broader problem: the NFLPA's F- field grade, the bland fan experience, the stadium's lack of identity, and why Giants fans still compare it unfavorably to old Giants Stadium.The second half shifts into roster construction. The Giants are getting heavier under John Harbaugh, and the hosts debate whether that means the team is finally building a more physical identity or just changing the average because of roster churn.Paulson Adebo also gets a spotlight after strong spring reports. The debate is not whether Adebo has talent — it is whether he can actually become the CB1-level player the Giants need after last year's injury comeback season.The final stretch hits two roster ideas: Najee Harris as a possible Devin Singletary replacement and Vita Vea as a defensive tackle name to monitor if Tampa Bay's contract situation gets worse. The hosts are clear that Vea is not a Giants trade story yet, but the Kayvon Thibodeaux angle makes the hypothetical hard to ignore.Merch: https://2giantgoofballs-shop.fourthwall.com/Support: https://buymeacoffee.com/2giantgoofballsAll episodes: https://2giantgoofballs.buzzsprout.com/Send us Fan MailSupport the show

Številni učinki, ki jih imajo na človeško telo kanabinoidi iz konoplje, so nam znani že tisočletja. Spoznanje, da tudi človeško telo izloča snovi, ki so jim zelo podobne, pa je staro šele dobrih trideset let. Kako naj si razložimo, da je človeško telo opremljeno s sistemom, ki se odziva na snovi iz konoplje – na fitokanabinoida THC in CBD? Odgovor se skriva v endokanabinoidnem sistemu. Ta je eden najbolj zanimivih in dolgo spregledanih regulacijskih sistemov v našem telesu. Med drugim ga sestavljata endokanabinoida anandamid in 2-AG ter specialni receptorji CB1 in CB2. V oddaji Ultrazvok raziskujemo, kako endokanabinoidi vplivajo na naše duševno zdravje in kakšno vlogo bi lahko imeli pri zdravljenju psihiatričnih bolezni, kot sta depresija in shizofrenija. Kaj o tem danes vemo in kakšno mesto imajo pri tem fitokanabinoidi iz konoplje, bosta pojasnila biokemičarka prof. dr. Tamara Lah Turnšek (NIB) in zdravnik Timur Mušić (UKC Ljubljana). Sogovornika Ultrazvoka sta v znanstveni reviji Biomedicines objavila pregledni članek o izsledkih študij, ki obravnavajo vlogo endokanabinoidnega sistema pri nevropsihiatričnih motnjah. Avtorja ugotavljata, da endokanabinoidni sistem predstavlja obetavno terapevtsko tarčo pri teh motnjah, vendar so za boljše razumevanje njegovih mehanizmov delovanja ter za potrditev varnosti in učinkovitosti terapevtskih pristopov potrebne nadaljnje predklinične in klinične raziskave. Originalni članek TUKAJ Foto: Konoplja/ slika je simbolična/ Pixabay

Send us Fan MailYour body has a built-in system designed to work with cannabinoids, and once you understand it, edibles make a lot more sense. We're talking about the endocannabinoid system (ECS): what it is, why scientists only officially identified it in the 1990s, and how it quietly regulates mood, pain modulation, sleep cycles, appetite, memory, and immune function in the background every day. If you've ever felt like cannabis “randomly” hits differently, the ECS is a big part of that story.We walk through the ECS in plain language: the endocannabinoids your body makes (including anandamide and 2-AG), the CB1 and CB2 receptors they bind to, and the enzymes that build and break these compounds down. From there, we connect the dots to THC and CBD, why THC-heavy use can drive CB1 receptor downregulation, and why a tolerance break can bring your sensitivity back online. If you use cannabis edibles, you'll also hear why metabolism matters, including the role of the liver and 11-hydroxy-THC.Then we get timely: summer. Heat, circulation changes, dehydration, and even increased outdoor activity can all shift how your ECS behaves, which can change edible onset, intensity, and duration even when your dose stays the same. We close with practical, harm-reducing tips for better dosing: start lower, hydrate early, eat a real meal, and use precise dosing if you make edibles at home.If this helped you see cannabis through a clearer scientific lens, subscribe, share it with a friend who needs the ECS explained, and leave a review so more curious people can find the show.Support the show Visit the website for full show notes, free dosing calculator, quiz, recipes and more. 

Contributor: Travis Barlock, MD Educational Pearls:   Endocannabinoid System: THC binds CB1 and CB2 receptors in neurons and immune cells Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in cannabis CB1 and CB2 receptors typically bind endogenously-produced 2-arachidonoylglycerol (2-AG) and anandamide (AEA) to regulate pain, stress, and inflammation THC similarly binds CB1 and CB2, leading to the cannabinoid high: euphoria, paranoia, anxiety, analgesia, anti-inflammation, and appetite, among a variety of others Ingestion via edibles, vice inhalation via smoking, leads to chemical modification of Δ9-THC to 11-hydroxy-Δ9-THC, which more easily crosses the blood-brain barrier and binds CB1 with higher affinity, leading to increased psychoactivity   Cannabinoid Hyperemesis Syndrome (CHS): Chronic THC use leading to the classic presentation of persistent nausea and intense, frequent vomiting Chronic activation of CB1 receptors in brain builds a tolerance and dependence on THC, in addition to chronic activation of the capsaicin and vanilloid receptor TRPV1, which binds capsaicin or is activated by heat Treatment by warm showers works due to TRPV1 activation by heat Treated with benzodiazepines, fluids, and gastro-intestinal or central nervous system agents according to patient presentation   Over 200 synthetic cannabinoids have been created (K2, spice, black mamba, mojo, etc), which are more dangerous and can lead to a variety of etiologies   Acetaminophen binds CB1 receptors to reduce inflammatory pain   References Loganathan P, Gajendran M, Goyal H. A Comprehensive Review and Update on Cannabis Hyperemesis Syndrome. Pharmaceuticals (Basel). 2024;17(11):1549. Published 2024 Nov 18. doi:10.3390/ph17111549  Wall ME, Sadler BM, Brine D, Taylor H, Perez-Reyes M. Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women. Clin Pharmacol Ther. 1983 Sep;34(3):352-63. doi: 10.1038/clpt.1983.179. PMID: 6309462.  Mills B, Yepes A, Nugent K. Synthetic Cannabinoids. Am J Med Sci. 2015 Jul;350(1):59-62. doi: 10.1097/MAJ.0000000000000466. PMID: 26132518. Klinger-Gratz PP, Ralvenius WT, Neumann E, et al. Acetaminophen Relieves Inflammatory Pain through CB1 Cannabinoid Receptors in the Rostral Ventromedial Medulla. J Neurosci. 2018;38(2):322-334. doi:10.1523/JNEUROSCI.1945-17.2017   Summarized by Sam Pahl | Edited by Sam Pahl & Ahmed Abdel-Hafiz, NREMT-P   Donate: https://emergencymedicalminute.org/donate/ Join our mailing list: http://eepurl.com/c9ouHf

Send us Fan MailPregnenolone, a neurosteroid derived from cholesterol, affects brain activity and shows promise for treating mood and substance abuse disorders.TOPICS DISCUSSED:Steroid Biosynthesis: Cholesterol converted to pregnenolone, the precursor for all steroid hormones including cortisol, aldosterone, and sex hormones.Corticosteroids: Synthetic versions like prednisone primarily target glucocorticoid receptors for anti-inflammatory uses but can impact mood and cognition.Pregnenolone Mechanisms: Positive allosteric modulator of NMDA receptors for cognition and negative allosteric modulator of CB1 cannabinoid receptors.Allopregnanolone: GABAergic derivative of pregnenolone; its IV form Brexanolone is FDA-approved for postpartum depression.Clinical Trials: Pregnenolone at 100-500 mg improved depressive symptoms in placebo-controlled studies of bipolar disorder patients.Cannabis Interaction: THC robustly induces brain pregnenolone production; supplementation may reduce cannabis and alcohol use.Corticosteroid Brain Impact: Prednisone use associated with smaller hippocampal volumes and memory deficits.ABOUT THE GUEST: Sherwood Brown, MD, PhD is Vice Chair for Clinical Research in the Department of Psychiatry at the University of Texas Southwestern Medical Center in Dallas. With a background in chemistry, his research focuses on steroids and comorbidities in people with mood disorders.RELATED EPISODE:M&M 124: Hormonal Contraception, Sex Hormones, Menstruation, Pregnancy, Puberty, Estrogens, Androgens, Effects of Birth Control on Cognition | Adriene BeltzSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

   The bold Chiefs do it again moving up from the 9th pick to number 6 to draft the "smooth" Monsoor Delane out of LSU.  This gifted corner is expected to be a much more impactful corner than Trent McDuffie and will save the team $80 million over the next four years versus their former CB1.  And wait until you hear him.  He's got natural leader written all over him.  Long gone are the days of sitting and just drafting the highest rated player on the board.  These championship caliber Chiefs are relentless in getting the player they need.  And they did it again.    Delane was surprised and thrilled but the second happiest man Thursday was defensive coordinator Steve Spagnuolo who had a rough off season watching his player let go to make more money elsewhere.    KU is borrowing even more money to run their athletics department and it feels more and more like how DC works.    We have some incredible listener emails to share that could bring a tear to your eye and/or make you laugh.    The SPLC scam is particularly alarming to Ron Freeman, author of the book "Rethinking Race."   He shares his thoughts.    And we have a song for you to finish up that's fitting based on one of the stories we featured about my childhood earlier in the week.

What's up all you stoners! Mr and Mrs Weedman are back with another round of cannabis headline news, reports, research and they share some stoner stories too - in an effort to #StompTheStigma and #FreeThePlant. Their advocacy is intended to educate and entertain consumers, from the most OG Toker all the way to the Day 1 Experimenter.  They share their understanding of cannabis and they break down the barriers and stigmas that the War on Drugs created around this phenomenal plant that's so simple yet so complex.  Before they get into this week's big topics, they get normal - seshing on Broken Lollipop from The Art of Genetics. This week Mr Weedman talks about new data showing CBD can positively impact Alzheimer's disease and he talks about the positive benefits of vaporized cannabis vs traditional combustion.  Mrs Weedman shares an update on cannabis use reducing the need for opioid and sleep aid medications, she delivers a piece about the discovery of the CB1 receptor and the endocannabinoid system, and she covers a perspective on the manipulation of marijuana as a political tool. Thanks for listening, as always hit us up!TWITTER: @weedman420podYouTube: Weedman420 ChroniclesEMAIL:  weedman420chronicles@gmail.comSHOP: www.eightdecades.comIG: @eightdecadesEMAIL: eightdecadesinfo@gmail.comSesh Connect: IG @the_art_of_genetics #CannabisTruth #StompTheStigma #HomeGrow #FreeThePlant #Stoners #rosin  #Potheads #CannabisEducation #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes #PodcastCannabis #eightdecades #CannabisLifestyle #HealthyLifestyle #NaturalMedicine #CannabisIndustry #PlantMedicine #News #WeedResearch #MedicalMarijuana #Infused #420Podcast #420Education #Health #WeedWellness #WorldNews #Gardening #420Culture #hemp #edibles #weed #gummies  Article Links:* https://www.greenstate.com/health/cbd-shows-promise-for-alzheimers-in-early-study/* https://www.marijuanamoment.net/medical-marijuana-helps-people-stop-using-opioids-sleeping-aids-and-other-prescription-drugs-study-shows/* https://www.marijuanamoment.net/vaporizing-marijuana-reduces-harmful-inhaled-byproducts-by-99-compared-to-joint-smoking-new-study-shows/* https://sechat.com.br/en/noticia/allyn-howlett-and-the-discovery-of-the-cb1-receptor-the-gateway-to-the-endocannabinoid-system?utm_source=flipboard&utm_content=user/ChefJeff314* https://cannabis.net/blog/opinion/cannabis-as-a-political-tool-they-were-never-fighting-a-drug-they-were-fighting-youCOPYRIGHT 2021 WeedMan420Chronicles©Suggestions? Questions? Chat with us here.Support the show

Analyzing my full Cornerback Rankings for the 2026 NFL Draft! Sign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/HMA Get EXCLUSIVE Draft Content AND Support My Channel @ https://www.patreon.com/thatfranchiseguy Join my Community Discord Server! https://discord.gg/D9cp7yY Information Guide for Grades & Traits you see on screen! https://docs.google.com/spreadsheets/d/1tsP2s5Dgb_s5TWlMnh5evK1pa_Em6yYv9-PXlRxLrIo/edit?usp=sharing Timestamps Intro 0:00 CB10 1:23 CB9 7:05 CB8 16:00 CB7 23:37 CB6 31:18 CB5: 37:33 CB4 43:00 CB3 48:31 CB2 56:36 CB1 1:03:26

The Giants can add speed, ball skills, and long-term upside by drafting a corner in 2026, but they can also spend real draft capital and still come away without a true boundary answer. If Joe Schoen goes corner early, which prospect actually fixes CB1 instead of just adding another name to an unsettled room?Follow on Spotify so you do not miss the next episode, and if you listen on Apple Podcasts, please leave a 5-star rating and review. It helps more Giants fans find the show.In this episode, Drew and Rob count down their top 10 cornerbacks in the 2026 NFL Draft and keep the conversation locked on the question that matters most for the Giants: who can really hold up outside and become the long-term boundary answer? They work through the tradeoff between upside and reliability, debate whether it is smarter to chase traits or play it safer at one of the hardest positions to project, and stack the class based on fit as much as talent. Mansoor Delane finishes at the top because he feels like the safest bet to become a real outside starter, while Jermod McCoy brings top-tier talent but major medical risk after the ACL injury. Colton Hood gets pushed near the top because of his physical press-man style and upside, even with the smaller sample size. D'Angelo Ponds creates one of the biggest debates in the episode because the playmaking is real, but the size and projection questions are just as real. The guys also break down Davison Igbinosun, Treydan Stukes, Keionte Scott, Keith Abney II, Chris Johnson, and Brandon Cisse, with a strong focus on which prospects are true perimeter corners versus slot or flex pieces. The result is less a generic top-10 list and more a Giants-specific argument about how to avoid spending premium draft capital on a corner who still does not solve the real problem.Before the CB countdown, the show opens with quick Giants news, including the Brandon Allen signing, local pro day names, reported interest in Georgia Tech guard Kalen Rutledge, and a visit with veteran defensive tackle D.J. Reeder. The episode also closes with the Goofballs accidentally locking themselves into a future combine challenge after the audience hit the Super Chat number live.This is the audio from yesterday morning's live show.Merch: https://2giantgoofballs-shop.fourthwall.com/ Support: https://buymeacoffee.com/2giantgoofballs All episodes: https://2giantgoofballs.buzzsprout.com/Send us Fan MailSupport the show

FC Dallas took care of business in definitive fashion, beating D.C. United 4-nil at Audi Field for the club's second biggest road win in franchise history. Sam, Ryan, and Steve break down Dallas' strongest road performance of 2026 including a great night for their CB1, what a debuting DP showed in his brief tenure, and what all this means for the team as they hit a three game home stretch starting next Saturday.This program originally aired on the FC Dallas Radio Network on April 4th, 2026. 

With the 2026 NFL Draft less than a month away, this episode of Disguised Coverage details the biggest needs on the Buffalo Bills roster and how they can look to fill them in the draft. Players, skillsets, roles, position groups, fits, and more0:00 | Opening thoughts5:10 | Questions and comments from the live chat31:24 | Nose Tackle50:44 | LB, 4i/DE/IDL, and Edge 1:20:35 | Safety1:29:09 | WR and CB1:41:39 | One Pie Pizza1:43:48 | Closing thoughtsPresenting Sponsor - One Pie Pizza https://www.onepiepizza.com/ Elevated Catering of Buffalo https://elevatedcateringbuffalo.com/Tell them Cover 1 and Disguised Coverage sent you!!Follow on Twitter: https://twitter.com/Pro__AntFollow on Bluesky: https://bsky.app/profile/proant.bsky.socialCover 1 would love to hear your thoughts on this topic and the show in general. Comment below and let us what you think!One Pass Premium Membership - https://www.cover1.net/onepass/Don't miss out on our PREMIUM CONTENT-Access to detailed Premium Content.-Access to our video library.-Access to our private Slack channel.-Sneak peek at upcoming content.-Exclusive group film room sessions & much more.Thank you for watching this video, we can't do it without the support of our fans. If you have any ideas for content you'd like to see from us, comment below. -DOWNLOAD THE COVER 1 MOBILE APP!► Android: https://play.google.com/store/apps/details?id=com.coverapp► iOS: https://apps.apple.com/us/app/id1532587486► Subscribe to our YouTube channel - https://www.youtube.com/channel/UClL6eJS1s8xmRoYRQbYgxQQ?sub_confirmation=1► Subscribe to our Cover 1 Network channel - https://podcasts.apple.com/us/podcast/cover-1-sports/id1370162953 -Cover 1 provides a multi-faceted analysis of the NFL and NFL Draft including Podcasts, Video blogs, Commentary, Scouting Reports, Highlights, and Video Breakdowns. NFL footage displayed is not owned by Cover 1. -Follow Us HereTwitter: https://twitter.com/Cover1Instagram: https://www.instagram.com/@Cover_1_Facebook: https://www.facebook.com/Cover1NFL/Official Merchandise:https://teespring.com/en-GB/stores/cover-1The Cover1.net website and associated Social Media platforms are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by the NFL or any of its clubs, specifically the Buffalo Bills. All products, marks, and company names are the registered trademarks of their original owners. The use of any trade name or trademark is for identification and reference purposes only and does not imply any association with the trademark holder of their product brand.

Ben and Dom are joined by The Mirror's Charlie Wilson to break down the best linebackers and cornerbacks who will be selected at the NFL Draft in less than a month. Which of Ohio State's top LBs is the number one? Is Georgia's CJ Allen overrated? Can Tennessee's Jermod McCoy be CB1 even if missed all of last season with a torn ACL? All this and more is answered in another episode of College Daze. Got questions? Hit up ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@tweetsfromben⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@domcorbsNFL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or email ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠collegedazepod@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Socials: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/tweetsfromben⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/domcorbsNFL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/thencshow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/thencshow/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Ben Standig breaks the news that the Washington Commanders have signed cornerback Ahkello Witherspoon to a one-year deal and discusses what it could mean for their draft strategy. With corner still in the conversation at No. 7, Standig explains why he believes Mansoor Delane has a better chance to develop into a true CB1 than Carnell Tate does as a WR1, and how that could influence Washington's decision.

In this episode of the Essential Wellness Podcast, the team explored the powerful, research-backed benefits of doTERRA's Copaiba oil—highlighting its impact on strength, body composition, pain management, and sleep. Led by Aisha Harley and Dr. Josie, the discussion centred around a clinical study showing significant results in just 30 days, along with practical protocols for daily use. From its role as a direct CB2 receptor activator to its advantages over CBD products, this episode breaks down why Copaiba is becoming a foundational tool for long-term wellness. The conversation also included real-life applications, dosing strategies, and synergistic blends for sleep, recovery, and inflammation support.    

Cannabis has gone mainstream, but perioperative risk has not improved. THC products are far more potent than they were decades ago, emergency room visits are climbing, and many patients still walk into surgery thinking that it's safe. We want anesthesia professionals to have a clearer, evidence-informed way to think about cannabis and anesthesia before the next case. We open the latest APSF newsletter feature article, “Cannabis and Anesthesia,” and bring in author Trisha Meyer to frame why this topic matters now. Together, we walk through the pharmacology that shows up at the bedside: THC vs CBD, CB1 and CB2 receptors, the endocannabinoid system, and how route of use changes onset and duration. Then we get practical about drug-drug interactions and highlight a free interaction-checking resource you can use in real time.From there, we map cannabis use across the perioperative timeline. Preop means asking better questions and documenting details like product type, dose, frequency, last use, and withdrawal symptoms, plus knowing when intoxication should delay elective surgery and when cardiac risk may need more workup. Intraop means expecting possible higher propofol and sedative requirements, watching for cardiovascular instability, and preparing for airway hyperreactivity and bronchospasm in inhaled users. Postop means planning for higher pain needs, using multimodal analgesia, and recognizing withdrawal, hypothermia, and shivering patterns that can surprise teams.If you care about perioperative patient safety, listen, share this with a colleague, and subscribe so you don't miss what's next.For show notes & transcript, visit our episode page at apsf.org: https://www.apsf.org/podcast/299-cannabis-and-anesthesia/© 2026, The Anesthesia Patient Safety Foundation

On this Kaya Cast episode, host Tommy Truong sits down with Dr. Bonni Goldstein of Goldstein Wellness to unpack the science, medicine, and business of cannabis in epilepsy and beyond. Dr. Goldstein is the Chief Medical Advisor for Neurotech International, helping to develop effective cannabinoid-based formulations for autism and other pediatric neurologic conditions.From the endocannabinoid system to multimodal cannabinoids like CBD, CBDV, CBG and CBDA, they discuss how clinicians tailor regimens for pediatric and adult patients, why dosing is start low and go slow, and what the latest clinical data show about seizure reduction and quality of life. Bonni shares her journey from pediatric emergency medicine to medical cannabis, the Charlotte story that helped launch CBD in epilepsy, and practical dosing, safety, and drug interaction considerations. They also talk about the business side: educating clinicians, ensuring product quality, and Goldstein Wellness's free clinician education program with about 50 videos, plus a patient-facing network of vetted cannabis clinicians. If you're a dispensary executive, grower, or clinician, this episode offers actionable insights on education, regulation, and patient-centered cannabis care. Find out more about Goldstein Wellness at:https://goldsteinwellness.com/https://www.linkedin.com/in/bonnigoldsteinmd/https://www.linkedin.com/company/goldstein-wellness/ 00:00 CBD Seizure Success00:17 Meet Dr Bonni00:58 From ER to Cannabis02:00 Cancer Patient Turning Point04:30 ECS Explained Simply08:16 Receptors and Evolution11:44 Dysfunction and Conditions13:40 Research Barriers and COVID16:42 CBD for Intractable Epilepsy19:51 Charlotte Figi Breakthrough24:13 How CBD Calms Seizures26:47 Dosing and Other Cannabinoids29:54 Beyond Seizure Control31:08 Medical vs Recreational Divide31:50 Medical vs Adult Use32:39 Teaching Cannabis Literacy34:26 Beyond CBD and THC34:53 CBG Effects and Dosing38:53 CBG Biomarkers Research41:16 CBN and Sleep Evidence43:32 CBDA Raw Anti Inflammatory46:55 CBDA vs CBD Decisions50:41 Future Biomarker Guided Care52:23 THCV Metabolism and Caution57:06 Synthetic Cannabinoid Risks01:00:03 Wrap Up and Resourcesmedical cannabis, cannabis for epilepsy, CBD for seizures, CBDV research, CBG benefits, CBDA cannabinoids, endocannabinoid system explained, pediatric epilepsy treatment, adult epilepsy cannabis, seizure reduction data, cannabinoid dosing guidelines, start low go slow cannabis, cannabis drug interactions, CBD drug safety, medical cannabis for autism, pediatric neurologic conditions, cannabinoid formulations, evidence based cannabis medicine, clinical data cannabis epilepsy, quality of life seizure patients, Dr Bonni Goldstein, Goldstein Wellness, Neurotech International, cannabinoid clinical trials, CBD epilepsy Charlotte story, Epidiolex discussion, cannabis and seizure disorders, neurologist cannabis education, clinician cannabis training, cannabis CME education, vetted cannabis clinicians network, patient centered cannabis care, cannabis compliance and regulation, dispensary education strategy, cannabis product quality standards, GMP cannabis manufacturing, lab tested cannabinoids, full spectrum vs isolate CBD, multimodal cannabinoids, entourage effect science, cannabis pharmacology, cannabis titration strategy, pediatric dosing cannabis, cannabis safety in children, cannabis and antiepileptic drugs, clobazam CBD interaction, valproate CBD interaction, liver enzyme monitoring cannabis, seizure frequency reduction, refractory epilepsy cannabis, Lennox Gastaut syndrome CBD, Dravet syndrome CBD, autism spectrum disorder cannabis research, neuroinflammation and cannabinoids, CB1 and CB2 receptors, endocannabinoid deficiency theory, cannabis telemedicine clinicians, state medical marijuana laws, Schedule III cannabis implications, dispensary operator insights #kayacast #cannabis #tips #dispensaries #business #podcast

Marshall Green of Giants Now By Chat Sports is on the show to talk about the Giants first week of free agency, Evan Neal returning, the newest Free agents, and the Giants signing WR Calvin Austin from the Steelers Follow Marshall here:https://x.com/MarshallGreen_?s=20 https://www.youtube.com/@NYGiantsTV Download the Fanatics Sportsbook app , use code JOMBOY https://fanatics.onelink.me/5kut/JOMBOY New customers who sign up and Bet $5, Get $100 in FanCash*. Use FanCash on bonus bets, profit boosts, team gear and more on Fanatics.com.  *New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MO, NC, NJ, NY, OH, PA, TN, VA, VT, WV, or WY. Must toggle on this promotion in your bet slip and wager $5+ cash on any market (min. odds -500) within 7 days of account opening to receive $100 in FanCash. Promotional FanCash expires 7 days from issuance (at 11:59pm ET). Terms, including FanCash terms apply-see Fanatics Sportsbook app. Use FanCash on bonus bets, profit boosts, team gear on Fanatics.com and so much more. 00:00 Giants Sign Calvin Austin + Marshall Green Talks Free Agency 01:30 Giants Sign WR Calvin Austin 07:00 How can the offense use Austin 13:30 Giants Now by chat sports joins the show 14:10 Evan Neal is back 17:30 Giants want a heavier OL 20:15 The Giants needed to be more aggressive in Free Agency 26:10 Expectations for Isaiah Likely 19:47 Likely will help Jaxson Dart create big plays 33:30 Playing in the slot 36:50 Ricard will highlight the running game 41:00 Drafting a WR 45:55 Need another LB with Edmunds 51:00 Worried about the CB room 56:55 Need Adebo to play like a  CB1 01:00:11 Taking special teams seriously  01:03:15 Run defense is still bad Check out our Merch: https://shop.jomboymedia.com/collections/talkin-giants Subscribe to JM Football for our NFL coverage: https://www.youtube.com/@JMFootball Follow all of our content on https://jomboymedia.com #giants #nygiants  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Mock Draft Monday takes a whole new angle this week as we dig into the athletic benchmarks and physical profiles the Packers have historically favored at every position — then build an entire mock draft around them. Using combine data going back to 2018, we compare Green Bay's draft tendencies against NFL averages to find the prospects who truly fit the Packers' DNA. Deep dive into Packers combine benchmarks vs. NFL averages at every position — what actually separates Green Bay's picks from the rest of the league? A stunning revelation: the Packers have invested just ONE draft pick at cornerback in rounds 1-4 since 2018 (Eric Stokes), making CB1 an urgent need Full mock draft featuring Chris Johnson (CB, San Diego State), small-school riser Caleb Proctor (DT, SE Louisiana), Alabama center Parker Brailsford, and more Late-round gems explored including Mason Rieger's Shrine Bowl explosion, Joe Fagnano's breakout season at UConn, and Khalil Dinkins' untapped tight end potential Whether you're a draft junkie or just want to understand how Green Bay builds its roster, this one's packed with data, film notes, and fresh names for your draft board. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Website: https://nfldraftgrades.com/ My Board: https://nfldraftgrades.com/board/83a18c42-7a0b-4590-8d1b-453e49840d02

Mock Draft Monday takes a whole new angle this week as we dig into the athletic benchmarks and physical profiles the Packers have historically favored at every position — then build an entire mock draft around them. Using combine data going back to 2018, we compare Green Bay's draft tendencies against NFL averages to find the prospects who truly fit the Packers' DNA. Deep dive into Packers combine benchmarks vs. NFL averages at every position — what actually separates Green Bay's picks from the rest of the league? A stunning revelation: the Packers have invested just ONE draft pick at cornerback in rounds 1-4 since 2018 (Eric Stokes), making CB1 an urgent need Full mock draft featuring Chris Johnson (CB, San Diego State), small-school riser Caleb Proctor (DT, SE Louisiana), Alabama center Parker Brailsford, and more Late-round gems explored including Mason Rieger's Shrine Bowl explosion, Joe Fagnano's breakout season at UConn, and Khalil Dinkins' untapped tight end potential Whether you're a draft junkie or just want to understand how Green Bay builds its roster, this one's packed with data, film notes, and fresh names for your draft board. This episode is brought to you by PrizePicks! Use code PACKDADDY to get started with America's #1 fantasy sports app. https://prizepicks.onelink.me/LME0/PACKDADDY To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Website: https://nfldraftgrades.com/ My Board: https://nfldraftgrades.com/board/83a18c42-7a0b-4590-8d1b-453e49840d02

Rams LAFB Show | Ryan Anderson w/ Cody Alexander (Match Quarters) On this episode of the Rams LAFB Show, Ryan Anderson is joined by defensive guru Cody Alexander of the Match Quarters Substack and Let's Talk Ball podcast to break down where the Rams stand after coming up just short of the Super Bowl — and what needs to change in 2026. What we cover: ️ Why the Rams' defense stalled late — and how pass-rush depth (not just stars) is the real issue Chris Shula's scheme, blitz rates, and why the front & backend stopped complementing each other Cornerback problems: Do the Rams need a true CB1, a nickel, or just more bodies? Ranking the Rams' young defensive linemen (Verse, Turner, Young, Fisk) and who's worth paying ️ What the Rams can learn from Super Bowl defenses that win with four up front Kliff Kingsbury to the Rams: what he actually brings beyond the “Air Raid” label How Kingsbury + Nate Scheelhaase could evolve McVay's offense and prep for life after Stafford The Rams' long-term QB plan — draft, develop, or wait for the next big opportunity? If you love real Xs & Os, smart roster-building talk, and zero hot-take fluff, this episode is for you. Check out Cody's work: Match Quarters Substack Let's Talk Ball podcast Like, subscribe, and let us know in the comments: What should the Rams fix first — cornerback or pass-rush depth? Use promo code RAMSLAFB on Sleeper and get 100% match up to $100! https://Sleeper.com/promo/RAMSLAFB. Terms and conditions apply. #Sleeper Become an LAFB Lifer and get special perks by joining our Exclusive Los Angeles Rams Community: https://www.lafbnetwork.com/plans/join/ Check out our FREE Rams Message Board: https://www.lafbnetwork.com/forums/forum/los-angeles-rams/ Listen to our Rams Podcast: https://podcasts.apple.com/us/podcast/the-rams-skinny-a-los-angeles-rams-podcast/id1707103542 Check Out Our Rams LAFB Merch: https://lafbnetwork.myshopify.com/ Go to www.LAFBNetwork.com for FREE full access to all of our podcasts and join the community! Social Media: @LAFBNetwork | @RyanDyrudLAFB | @RLAndersonLAFB Sponsors: Sean McVay is the Los Angeles Rams' Football Head Coach as the team heads into the 2025 NFL Season, looking to build upon their playoff divisional appearance from one year ago. Matthew Stafford is back at quarterback, and he will lead the Rams throughout the season with Puka Nacua, Davante Adams, and Kyren Williams. Jared Verse and Braden Fiske will look to build upon stellar rookie campaigns on defense for the Rams. Make sure to subscribe to the Rams LAFB YouTube Channel and head to https://www.lafbnetwork.com for all of your Los Angeles Rams content needs! #rams #nfl #nflshorts #ramshouse #all22 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the December 2025 Emergency Medicine Practice article, Diagnosis and Management of Cannabis-Related EmergenciesEpisode Outline: [0:00] IntroductionWelcome and show overview by Sam AshooMention of resources at ebmedicine.net[0:46] Episode StartHosts introduce themselves: Sam Ashoo and Dr. T.R. EcklerDr. Eckler's background and experience with cannabis cases in Colorado[1:16] Topic IntroductionFocus on diagnosis and management of cannabis-related emergenciesPrevalence and importance in emergency medicine[1:34] Legal LandscapeOverview of cannabis legality across statesMedicinal vs. non-medicinal use[3:03] Increase in ED VisitsStatistics: ~1 million cannabis-related ED visits annuallyDemographics: younger population most affected[3:52] Synthetics and ChallengesDiscussion of synthetic cannabinoids and their risksIssues with detection and legality[4:50] Clinical SpectrumRange of presentations: from nausea/vomiting to psychosis and seizuresImpact on different age groups[6:34] FDA-Approved UsesCannabis-derived products approved for specific medical conditions[7:20] Physiology and PathophysiologyCannabinoid receptors (CB1 and CB2) and their effectsDifferences between plant-derived and synthetic cannabinoids[9:10] Chronic Use and WithdrawalDownregulation of receptors, withdrawal symptoms, and persistent nausea[10:20] Product Forms and Delivery MethodsSmoking, edibles, oils, tinctures, suppositories, topicals, etc.Risks associated with concentrated forms (e.g., wax, oils)[12:00] Clinical Effects by SystemPsychiatric: anxiety, psychosis, paranoiaCardiovascular: tachycardia, MI risk, QT prolongationPulmonary, renal, metabolic, dental, and ocular effects[13:50] Cannabinoid Hyperemesis Syndrome (CHS)Phases: prodrome, hyperemesis, recoveryHot showers as a diagnostic clue[16:00] Withdrawal SyndromeSymptoms and timelineExacerbation with synthetic cannabinoids[18:15] Counseling and ManagementImportance of cessation and patient educationTimeline for symptom improvement[18:42] Differential DiagnosisBroad differential for persistent nausea/vomiting and abdominal painImportance of considering other causes[20:55] Diagnostics and TestingLimitations of drug screens (false positives/negatives)Importance of EKG, labs, and imaging as indicated[23:10] Treatment ApproachesFirst-line: benzodiazepines, antiemetics (ondansetron, metoclopramide)Second-line: butyrophenones (haloperidol, droperidol), olanzapineCapsaicin as adjunct therapy[29:50] Complications and Special ConsiderationsRisks of undertreatment (e.g., Boerhaave syndrome, aspiration)Pediatric and pregnant populations: unique risks and reporting requirements[36:00] Five Practice-Changing TakeawaysElicit cannabis use historyKnow testing limitationsConsider ECG and appropriate labsUse butyrophenones when indicatedAdmit if symptoms are refractory[39:00] ConclusionEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Where are you listening from?Your kitchen might be the best dispensary you'll ever have, but the real magic happens in your brain. We pull back the curtain on the endocannabinoid system and show how edibles—especially THC—bind to CB1 receptors, ripple through dopamine, GABA, and serotonin, and shape everything from euphoria to anxiety to time distortion. If you've noticed that your favorite gummy doesn't hit like it used to, there's a reason: tolerance builds as your brain downregulates receptors. The good news is that sensitivity can return faster than you think with a short, intentional break.Ready to reset your relationship with cannabis? We're launching the Fresh Start Tolerance Break Challenge for January—daily check-ins, weekly videos, science-backed tips, and a supportive community to help you rebuild sensitivity, save money, and return with intention. Whether you're new to edibles or a seasoned home cook crafting your own infusions, this guide gives you the science and structure to make every dose count.Join the Challenge, share this episode with a curious friend, and leave a review to help others find the show.Join the waitlist at JoinBiteMe.com/challenge - Music by Alexander BluSupport the show Visit the website for full show notes, free dosing calculator, recipes and more.

CB1 inhibition is an approach that taps into the body's natural metabolism to burn fat while preserving muscle for more sustainable weight loss. Unlike GLP-1s, which suppress appetite, CB1 inhibition activates fat-burning processes. In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with Punit Dhillon, CEO of Skye Bioscience, for a conversation on CB1 inhibitor antibodies in the obesity space. Dhillon discusses GLP-1 weight-loss drugs like semaglutide having taken the world by storm, despite the concerns over side effects, as well as what CB1s could mean for the obesity and weight-loss field. You can listen to episode 227 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

The Boston Herald's Andrew Callahan and BSJ's Mike Giardi dive into whether Christian Gonzalez is actually having a down year. The guys look at his coverage numbers, how the Patriots are using him, and whether the expectations around a true CB1 are skewing the conversation. Patriots on CLNS Media is Powered by:

Hour 1 of The Drive kicks off with Zach and Phil cross talking with Dover and Cecil. The guys discuss the NFL and how there are no great teams in the AFC. Do the Broncos need to go out and make a trade before the trade deadline to add to their offense? Zach and Phil go in depth into Bo Nix's numbers when it comes to getting blitzed. How has Nix improved after seeing so many different defensive looks and blitzes over the past season and a half? The guys debate how impactful the injury to Patrick Surtain will be for the Broncos. Are Riley Moss and Kris Abrams-Draine up for the challenge of being CB1 and CB2? Zach shares the stats on how dominant this Nuggets team has been offensively and how hot of a start Jamal Murray is off to. 

In hour 3 of The Drive, Zach and Phil are joined by veteran NFL reporter James Palmer to discuss how the Broncos were able to impact the Cowboys' great offense, the concern level with Patrick Surtain potentially missing time, and Sean Payton's faith in the young Broncos including Harvey and Franklin. Should the Broncos be "buyers" at the NFL trade deadline to add an offensive piece? Where are Zach and Phil with Bo Nix after he had arguably his best game as a Broncos this past weekend? The guys debate how impactful the injury to Patrick Surtain will be for the Broncos. Are Riley Moss and Kris Abrams-Draine up for the challenge of being CB1 and CB2? Zach shares the stats on how dominant this Nuggets team has been offensively and how hot of a start Jamal Murray is off to. 

Starting today, all Coinbase One US subscribers will have early access to Coinbase Research. If you're a CB1 subscriber, check your inbox now. In this episode, we cover some of the topics from our latest Monthly Outlook. We also wade into the enterprise L1 debate following the announcement that long-time Ethereum Foundation researcher Dankrad Feist is joining Tempo — a new L1 focused on payments and stablecoins. We also walk through the latest Charting Crypto report where we unpack new investor survey signals, dig into our Global M2 Money Supply Index, and discuss the role of digital asset treasuries as a force for structural demand across BTC and ETH.Speakers:David Duong, CFA - Global Head of Investment ResearchBen Rodriguez - Senior Protocol SpecialistColin Basco - Research Associate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this mind-expanding episode, Darin sits down with Dani Fontaine — researcher, practitioner, and expert on the human body's forgotten communication system: the endocannabinoid system. They unravel how this network regulates everything from mood and sleep to pain and consciousness — and why it was deliberately scrubbed from mainstream medical education. Dani reveals how cannabinoids, light, sound, and nature all communicate with our body's receptor fields — shaping the way we feel, heal, and perceive the world. Together they explore the profound spiritual and scientific implications of this hidden system, and how it connects us back to balance, nature, and truth.     What You'll Learn 00:00:00 - Welcome to the SuperLife Podcast 00:00:32 - Sponsor: Energy Bits 00:01:52 - Introducing Guest Danny Fontaine: Cannabis Pioneer and Plant Medicine Healer 00:04:54 - Deep Dive: What is the Endocannabinoid System (ECS)? 00:06:30 - ECS: The Homeostasis and Retrograde Signaling System 00:09:20 - ECS as a Receptive System for Subtle Energies and Environment 00:10:23 - Endocannabinoid System Toning (X-Tone) 00:12:58 - When the ECS Gets Worn and Depleted 00:16:34 - ECS Receptors on Every Cell, Fascia, and Neural Makeup 00:19:14 - How the ECS Breaks Down: The Impact of False Light 00:22:11 - The ECS and Non-Photon Rich Food 00:23:40 - Modulating the ECS Through the Six Senses (Touch and Breath) 00:24:38 - Mitochondria and ECS Receptors (MTK, CB1) 00:25:14 - Endogenous ECS and the Need for Proper Nutrients 00:27:11 - Cannabis as our Phyto Twin: The Plant Factor 00:27:57 - THC and the Suppression of Anandamide (Bliss Molecule) 00:31:44 - Sponsor: Fatty 15 00:35:25 - The Vast Amount of ECS Research & Medical Suppression 00:38:27 - Cannabinoids, Pain, and Individual Assessment 00:40:29 - Modulating ECS with Nature: Terpenes like Pinene 00:42:51 - Olfactory System as the Most Sophisticated Input 00:47:03 - ECS as the "Microscope Moment" for Health 00:48:23 - Pinene, CB1, and TRP Receptors in Pain Management 00:50:39 - The ECS, Collagen, and Hyaluronic Acid Fluctuation 00:51:44 - Working with the ECS for Faster Results (Cancer and Genetic Mutations) 00:55:06 - Sponsor: SuperLife Patreon 00:56:39 - Measuring the ECS with Bio-Field Technology 00:57:29 - The Danger of THC Stacking and Immunosuppression 00:59:30 - Overwhelmed Cells and Fake Inputs 01:00:12 - Hemp as a Homeostasis Plant for the Planet (Soil Remediation/Carbon) 01:02:06 - ECS Strength in Animals vs. Humans 01:04:08 - Why Cannabis and Hemp Were Suppressed 01:07:07 - The Historical Use of Cannabis in Medicine 01:08:12 - Hemp's Nutritional Profile (Amino Acids and Omegas) 01:09:37 - Ayahuasca, Receptor Overexpression, and Looping 01:13:33 - Importance of ECS Knowledge and Application 01:14:58 - Exercise, Anandamide, and ECS Toning 01:15:22 - Cold Plunge and Shocking the ECS and Hormones 01:17:16 - Takeaways: Light, Movement, Sound, and Breath 01:21:41 - ECS: The Main Signaling and Communication System 01:23:28 - Final Thoughts: ECS as the Conduit to Self and Spirit     Thank You to Our Sponsors: Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. EnergyBits: Get 20% off your entire order by going to https://energybits.com/ and using code DARIN at checkout.     Find More from Dani Fontaine Instagram: @danifontaine Website: danifontaine.com Products: Try Dani's Nature Root     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com     Key Takeaway “Your endocannabinoid system isn't just a biology lesson — it's a bridge between your body and the universe. When you feed it light, breath, and truth, you remember what balance actually feels like.”

Packers fans, buckle up for another raw, unfiltered dive into the highs and lows of being a Green Bay diehard. In this episode, callers vent about the lackluster win over the Bengals, questioning why victories feel like letdowns amid injuries to stars like Jayden Reed and Christian Watson. We explore the eternal fan pessimism and whether switching allegiances to teams like the Lions or Chiefs would really fix anything. Breaking down fan negativity: Why can't we celebrate wins without nitpicking every flaw? Hilarious analogies: From hot wives in sweatpants to Patriots' "trash" Super Bowl runs despite losses. Hot debates: Is Keyshawn Nixon a legit CB1? Plus, calling out schemes that supposedly "hold back" WR1s like in fantasy football glory days. Injury frustrations and team envy: Callers ponder ideal squads and why Packers' issues aren't unique. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. If you're loving the late-night vibes, smash that subscribe button, drop a rating, and hit us up on social with your takes. Catch you next time for more Packers chaos - stay edgy! #PackersAfterDark #GoPackGo #NFLDrama To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast

Packers fans, buckle up for another raw, unfiltered dive into the highs and lows of being a Green Bay diehard. In this episode, callers vent about the lackluster win over the Bengals, questioning why victories feel like letdowns amid injuries to stars like Jayden Reed and Christian Watson. We explore the eternal fan pessimism and whether switching allegiances to teams like the Lions or Chiefs would really fix anything. Breaking down fan negativity: Why can't we celebrate wins without nitpicking every flaw? Hilarious analogies: From hot wives in sweatpants to Patriots' "trash" Super Bowl runs despite losses. Hot debates: Is Keyshawn Nixon a legit CB1? Plus, calling out schemes that supposedly "hold back" WR1s like in fantasy football glory days. Injury frustrations and team envy: Callers ponder ideal squads and why Packers' issues aren't unique. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. If you're loving the late-night vibes, smash that subscribe button, drop a rating, and hit us up on social with your takes. Catch you next time for more Packers chaos - stay edgy! #PackersAfterDark #GoPackGo #NFLDrama To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast

The Chicago Bears face a crucial matchup against the Washington Commanders on Monday Night Football. Can Caleb Williams build on his improved pass protection and lead the Bears to victory? The defense must contain the Commanders' potent run game, with TJ Edwards and Kyler Gordon returning to bolster the unit. Tyrique Stevenson steps into the CB1 role, aiming to shut down Jaden Daniels. Rome Odunze looks to continue his hot streak as Williams' favorite target. With both teams battling injuries, this game presents a prime opportunity for the Bears to gain momentum. Will Chicago's offensive line create holes for the struggling run game? Tune in to see if the Bears can secure their third straight win and climb back into playoff contention.Podcast Links: https://linktr.ee/ChiBearsCentralGet at us:Email: ChicagoBearsCentral@gmail.comTwitter:@ChiBearsCentralPhone: ‪(773) 242-9336‬Our Sponsors:* Check out Cigars International and use my code BEARSCENTRAL for a great deal: https://www.cigarsinternational.comAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.A new survey from CRB shows that most life sciences companies, particularly smaller biotechs, are not planning new investments in response to tariffs. The majority of manufacturing initiatives in the U.S. made in response to tariffs are coming from big pharma companies. Sky Bioscience's CB1 inhibitor, Nimacimab, showed promising weight-loss results when combined with Wegovy despite falling short of expectations in a mid-stage obesity trial. Amgen will offer its lipid-lowering drug Repatha directly to patients at a 60% discount. Biospace has honored 40 under 40 leaders in biopharma whose achievements reflect the industry's grit and impact. Pfizer beat out two other suitors for a takeover of Metsera. Maplight seeks a $227 million IPO for its neuropsych portfolio.AMT designation is taking its first steps amid uncertain benefits. Pharming's restructuring triggers a 20% reduction in its workforce. Experts are forging new paths to address scalability, cost, and other barriers surrounding cell therapy production.The CDC has adopted ACIP recommendations on chickenpox and COVID-19 vaccines. Stay tuned for upcoming events such as webinars on mRNA medicine, biopharma deregulation, and transforming digital sequences into mRNA.Various job opportunities in the life sciences industry include positions at Sonothera, Eli Lilly and Company, and Amgen.Support the show

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Systematic Review Findings: Cochrane umbrella review of 9 systematic reviews (51 trials; n=2,895) comparing active TENS with sham/usual care found uncertain efficacy due to: Very low-quality evidence (risk of bias, small samples, methodological limitations). Inconsistent adverse event reporting. Heterogeneity in TENS parameters and comparators. Authors note uncertainty may be confounded by inadequate dosing not being an inclusion metric. Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

On this week's edition of the Tapping The Keg podcast, Charlie & Mitch talk about the Green Bay Packers, Milwaukee Brewers, and the Wisconsin Badgers. Charlie and Mitch talk about Packers island. Which players and takes are we buying property on their 'islands'? Which ones are we selling? We discuss the Packers being the best team in the NFL, Keisean Nixon as CB1, Matthew Golden and muchore. The boys move on to discuss what the Milwaukee Brewers will look like in the next two weeks. Lastly, Charlie and Mitch talk about if the Wisconsin Badgers football job is still one of the best in the Big Ten.

Send us a textThe New York Giants' defense is under the spotlight in this episode of 2 Giants Goofballs as Drew and Rob deliver their 53-man roster predictions and react to major news about left tackle Andrew Thomas, who has officially passed his physical and is eligible to return. While Thomas is unlikely to suit up against the Patriots this Thursday, his presence off the PUP list is huge for the Giants' season outlook.We break down the entire defensive depth chart: Dexter Lawrence continuing to anchor the line, Roy Robertson-Harris and Rakeem Nunez-Roches providing veteran stability, and rookies like Darius Alexander and Elijah Chatman fighting to prove themselves. On the edge, the combination of Brian Burns and Kayvon Thibodeaux headlines a dangerous pass-rush group that also includes Abdul Carter and Chauncey Golston. At linebacker, Bobby Okereke and Micah McFadden remain the core, with Darius Muasau flashing potential alongside veterans Chris Board and Demetrius Flannigan-Fowles.The cornerback competition is one of the hottest battles of camp, with Deonte Banks trying to lock down CB1 duties while Cor'Dale Flott pushes for reps. Add in Paulson Adebo, Dru Phillips, Tre Hawkins, and Nic Jones, and this secondary is deeper than in years past. Safety also looks strong, led by Jevon Holland, rookie Tyler Nubin, Dane Belton, and K'Von Wallace. Special teams return intact with Graham Gano at kicker, Jamie Gillan at punter, and Casey Kreiter at long snapper.We'll also preview the Giants vs. Patriots preseason matchup, which the hosts will be attending. Expect insights on who needs to step up, what battles could be decided Thursday night, and how the Giants are preparing to finalize the roster.Thank you for watching & for your support. You made it to the bottom of the description so you must like the show!Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballsSubscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1Become a Member of the YouTube Goofball Channel for Perkshttps://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/joinFollow us On Facebookhttps://www.facebook.com/2giantgoofballsFollow us On Xhttps://x.com/2giantgoofballsPrefer Audio Only? Check Out Those Options Herehttps://2giantgoofballs.buzzsprout.com/Support the showThank you for watching & for your support. You made it to the bottom of the description so you must like the show! Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/ Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballs Subscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1 Become a Member of the YouTube Goofball Channel for Perks https://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/join Follow us On Facebookhttps://www.facebook.com/2giantgoofballs Follow us On Xhttps://x.com/2giantgoofballs

Send us a textThe New York Giants face the most critical stretch of the preseason as the 53-man roster deadline approaches, and the tough decisions are about to unfold. Drew and Rob are here live to break it all down for the Goofball Army. The quarterback situation is drawing headlines as rookie Jaxson Dart continues to push for the No. 2 job behind Russell Wilson, leaving Jameis Winston and Tommy DeVito in danger. At running back, Eric Gray is battling to keep his spot while Cam Skattebo and Dante “Turbo” Miller are showing flashes that could change the depth chart. Wide receiver has become a bloodbath with Lil'Jordan Humphrey, Beaux Collins, and Montrell Washington fighting for the final roster spots.The offensive line picture isn't any clearer. Evan Neal's move inside is creating a battle with Greg Van Roten at right guard, and the Giants must decide if James Hudson can hold down a starting job or if Marcus Mbow is ready to take over. On defense, Deonte Banks' inconsistency has left the CB1 job in question as Cor'Dale Flott continues to push him. Meanwhile, Elijah Chatman is getting looks at fullback, and while creative, the experiment raises the question of whether his defensive snaps are too valuable to risk.Brian Daboll has praised Jaxson Dart's command, toughness, and leadership, but even glowing reviews won't save everyone on this roster. Abdul Carter added fuel to the fire with his fiery comments about the Jets, showing both his confidence and his edge as a rookie. Every position group has players on the bubble, and the Giants' front office must balance loyalty to veterans with the upside of hungry young players.Thank you for watching & for your support. You made it to the bottom of the description so you must like the show!Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballsSubscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1Become a Member of the YouTube Goofball Channel for Perkshttps://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/joinFollow us On Facebookhttps://www.facebook.com/2giantgoofballsFollow us On Xhttps://x.com/2giantgoofballsPrefer Audio Only? Check Out Those Options Herehttps://2giantgoofballs.buzzsprout.com/#nygiants #giants #newyorkgiants #gmen #53manrosterSupport the showThank you for watching & for your support. You made it to the bottom of the description so you must like the show! Show Everyone You are a Goofball By Checking Out Our Merchandise Storehttps://2giantgoofballs-shop.fourthwall.com/ Support the Show on Buy Me a Coffee - Kill Our Livers Buy Us Beers!https://buymeacoffee.com/2giantgoofballs Subscribe to Our YouTube Channel - Best Way to Watch Our Contenthttps://www.youtube.com/@2giantgoofballs?sub_confirmation=1 Become a Member of the YouTube Goofball Channel for Perks https://www.youtube.com/channel/UC-tiLjkehiawtN-v6gMFViA/join Follow us On Facebookhttps://www.facebook.com/2giantgoofballs Follow us On Xhttps://x.com/2giantgoofballs

Storm Duck has established himself as CB1 of the Miami Dolphins, but the rest of the CB room is up for grabs. Ollie Gordon gains momentum in the battle for RB2. Hollywood's Headlines includes a fake Micah Parsons quote, a fight at the Jags/Saints game, and Hassan Whiteside's house is for sale.

Send us a textWhat is the core evolved function of the endocannabinoid system?Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system.About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core components like CB1 receptors and lipid-based molecules derived from omega-6 fatty acids; its cellular signaling, evolutionary role in energy storage for uncertain futures (exostasis vs. homeostasis); effects across tissues; motivation, appetite, pain relief, and anxiety regulation; biphasic effects of cannabinoids.Discussion Points:The endocannabinoid system acts as an "exostatic" regulator, promoting energy accumulation for future needs by enhancing food palatability, nutrient absorption, and fat storage, unlike "endostatic" systems that address immediate hunger.CB1 receptors appear in vertebrates with adipose tissue, suggesting an evolutionary link to storing fat for survival in unstable environments.Endocannabinoids are lipids from omega-6 fats; high intake boosts their levels, potentially fueling obesity by creating a self-perpetuating cycle of overeating.Activation of CB1 can have biphasic effects due to receptors on different cell types like excitatory vs. inhibitory neurons.Pregnenolone, a steroid precursor, acts as a natural CB1 inhibitor to prevent excessive activation, blocking harmful effects like psychosis from high THC doses.The system influences motivation beyond food, including sex and even human activities like sports or storytelling, by rewarding actions for potential future benefits.In the brain, CB1 on mitochondria and astrocytes modulates energy use, olfaction, and social stress transmission, with implications for disorders like Alzheimer's.Reference Paper:CB1 Receptor as the Cornerstone of ExostasisRelated episode:M&M 123: EndocanSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Richard Sherman goes inside San Francisco 49ers camp for exclusive, unfiltered conversations with George Kittle, Brock Purdy, Deommodore Lenoir, and head coach Kyle Shanahan. From locker room leadership and personal growth to Super Bowl expectations, it's a rare look at the mindset behind one of the NFL’s elite teams. 02:00 – George Kittle on training camp, leadership, and playoff memories.17:00 – Brock Purdy on fatherhood, Kyle Shanahan, and proving himself.33:40 – Deommodore Lenoir on becoming CB1 and leading the secondary.42:40 – Kyle Shanahan on roster rebuilding, QB development, and 2025 expectations. #VolumeSee omnystudio.com/listener for privacy information.

The Green Bay Packers had another eventful practice at Ray Nitschke Field, where second-year linebacker Edgerrin Cooper reminded everyone that he's really good. Meanwhile, cornerback Keisean Nixon continued his standout play this summer as "CB1." Wide receiver Romeo Doubs stayed hot, catching a touchdown in the RedZone Period ... but the day was dominated by Jeff Hafley's defense. (Which has become a theme this summer...) Oh, and the Milwaukee Brewers remain the hottest team in baseball. Vinny Rottino from FanDuel Sports Network joins the show to discuss.See omnystudio.com/listener for privacy information.

In today's episode of the Packernet Podcast, host Ryan Schlipp dives headfirst into the growing wave of criticism surrounding the Packers' defense. Using a recent viral exchange between a beat writer and a fan as a jumping-off point, Ryan dismantles some of the more extreme claims—like Keyshawn Nixon being CB1 as a problem, Rashan Gary being overpaid, and Caleb Williams “dog walking” the Packers defense. Ryan walks listeners through the data, challenges faulty narratives, and even gets a bit philosophical about the culture of constant negativity in the fanbase. Plus, shoutouts to Malik Turner for his big UFL moment and Christian Watson for the growing family! If you're looking for a no-nonsense, stats-driven defense of the Green Bay Packers, this one's for you. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast

In today's episode of the Packernet Podcast, host Ryan Schlipp dives headfirst into the growing wave of criticism surrounding the Packers' defense. Using a recent viral exchange between a beat writer and a fan as a jumping-off point, Ryan dismantles some of the more extreme claims—like Keyshawn Nixon being CB1 as a problem, Rashan Gary being overpaid, and Caleb Williams “dog walking” the Packers defense. Ryan walks listeners through the data, challenges faulty narratives, and even gets a bit philosophical about the culture of constant negativity in the fanbase. Plus, shoutouts to Malik Turner for his big UFL moment and Christian Watson for the growing family! If you're looking for a no-nonsense, stats-driven defense of the Green Bay Packers, this one's for you. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Shiloh Bigles. A certified functional nutrition counselor and founder of Level Minds CBD Health Club, joins Money Making Conversations Masterclass to discuss how CBD, functional nutrition, and holistic wellness help individuals manage pain, anxiety, and autoimmune disorders. She shares her personal experience overcoming lupus and Crohn’s disease through natural remedies.

In this episode of the Bioactive Podcast, Dr. Allyn Howlett—renowned neuroscientist and pioneer in cannabinoid research—shares her groundbreaking journey into the study of cannabis and the discovery of the CB1 receptor. Originally focused on neuronal hormones, Dr. Howlett recounts how her curiosity led to one of the most pivotal findings in medical cannabis science: the identification of the brain's first cannabinoid receptor. She dives into the mechanisms of THC, the function of cannabinoid receptors in the brain and body, and the discovery of the endocannabinoid system. The conversation explores the historical development of cannabinoid research, the barriers posed by the pharmaceutical industry, and the evolving relationship between academia and drug development. Dr. Howlett also discusses the future of cannabinoid science—including targeted therapies, pain relief, and the medical potential of cannabis compounds. This episode offers an essential look at the scientific foundation behind cannabis medicine and its impact on legalization, healthcare, and public perception.

The Chargers got a ton out of a very young secondary in 2024, with a revolving door at safety3. Will they spend big at cornerback to solidify their CB1 spot? Will they need to replace Elijah Molden? Shaping up for an interesting offseason in the back 7. 0:00 Show start 3:58 Pre-discussion on DB room and Minter 18:24 Top of the 2025 market 31:46 Pricey starters 43:27 Starters on a budget and role players Make sure to join up as channel members at: https://www.youtube.com/channel/UCBnSd0Mx4BHUXlpxVegCoOg/join To make your selections, go to PrizePicks.com/GUILTY and use code GUILTY for a first deposit match up to $100! Follow us on Twitter! Podcast: @GACPodcast17 Steven: @StevenIHaglund Tyler: @tylerjschoon Tyler's Patreon: https://patreon.com/TylerSchoon?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink #BlueWireVideo #NFL #Chargers #NFLPodcasts Learn more about your ad choices. Visit podcastchoices.com/adchoices