Podcast appearances and mentions of Michael Hughes

In this JCO Article Insights episode, Michael Hughes summarizes “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma" by Avet-Loiseau et al. published on June 09, 2025 along with an interview with author Dr Nikhil C. Munshi, MD. TRANSCRIPT Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I am interviewing Dr. Nikhil Munshi on the “International Myeloma Society and International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma” by Avet-Loiseau et al. At the time of this recording, our guest has disclosures that will be linked in the transcript. While some patients with multiple myeloma live for decades after treatment, others exhibit refractory or rapidly relapsing disease irrespective of treatment administered. We term this “high-risk myeloma.” Multiple risk stratification systems have been created, starting with the Durie-Salmon system in 1975 and evolving with the advent of novel therapeutics and novel treatment approaches. In 2015, the Revised International Staging System (R-ISS) was introduced, which incorporated novel clinical and cytogenetic markers and remained, until recently, a mainstay of risk stratification in newly diagnosed disease. Myeloma as a field has, just in the past few years, though, undergone explosive changes. In particular, we have seen groundbreaking advances not only in treatments - the introduction of anti-CD38 agents and the advent of cellular and bispecific therapies - but also in diagnostic technology and our understanding of the genetic lesions in myeloma. This has led to the proliferation of numerous trials employing different definitions of high-risk myeloma, a burgeoning problem for patients and providers alike, and has prompted attempts to consolidate definitions and terminology. Regarding cytogenetic lesions, at least, Kaiser et al's federated meta-analysis of 24 therapeutic trials, published here in the JCO in February of 2025 and recently podcasted in an interview with associate editor Dr. Suzanne Lentzsch, posited a new cytogenetic classification system to realize a shared platform upon which we might contextualize those trial results. This article we have here by Dr. Avet-Loiseau, Dr. Munshi, and colleagues, published online in early June of this year and hot off the presses, is the definitive joint statement from the International Myeloma Society (IMS) and the International Myeloma Working Group (IMWG). What is high-risk multiple myeloma for the modern era? The IMS and IMWG Genomics Workshop was held in July 2023 and was attended by international myeloma experts, collaborating to reach consensus based on large volumes of data presented and shared. The datasets included cohorts from the Intergroupe Francophone du Myélome (IFM); the HARMONY project, comprised of multiple European academic trials; the FORTE study, findings from which solidified KRd as a viable induction regimen; the Grupo Español de Mieloma Múltiple (GEM) and the PETHEMA Foundation; the German-Speaking Myeloma Multicenter Group (GMMG); the UK-based Myeloma XI, findings from which confirmed the concept of lenalidomide maintenance; Emory 1000, a large, real-world dataset from Emory University in Atlanta; the Multiple Myeloma Research Foundation Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass) dataset; and some newly diagnosed myeloma cohorts from the Mayo Clinic. Data were not pooled for analyses and were assessed individually - that is to say, with clear a priori understanding of whence the data had been gathered and for what original purposes. Consensus on topics was developed based on the preponderance of data across studies and cohorts. In terms of results, substantial revisions were made to the genomic staging of high-risk multiple myeloma, and these can be sorted into three major categories: A) alterations to the tumor suppressor gene TP53; B) translocations involving chromosome 14: t(14;16) (c-MAF overexpression), t(14;20) (MAFB overexpression), and t(4;14) (NSD2 overexpression); and C) chromosome 1 abnormalities: deletions of 1p or additional copies of 1q. In terms of category A, TP53 alterations: Deletion of 17p is present in up to 10% of patients at diagnosis and is enriched in relapsed or refractory disease. This is well-documented as a high-risk feature, but the proportion of the myeloma cells with deletion 17p actually impacts prognosis. GEM and HARMONY data analyses confirmed the use of 20% clonal cell fraction as the optimal threshold value for high-risk disease. That is to say, there must be the deletion of 17p in at least 20% of the myeloma cells on a FISH-analysis of a CD138-enriched bone marrow sample to qualify as high-risk disease. TP53 mutations can also occur. Inactivating mutations appear to have deleterious effects similar to chromosomal losses, and the biallelic loss of TP53, however it occurs, portends particularly poor prognosis. This effect is seen across Myeloma XI, CoMMpass, and IFM cohorts. Biallelic loss is rare, it appears to occur in only about 5% of patients, but next-generation sequencing is nevertheless recommended in all myeloma patients. Category B, chromosome 14 translocations: Translocation t(14;16) occurs in about 2% to 3% of patients with newly diagnosed disease. In the available data, primarily real-world IFM data, t(14;16) almost always occurs with chromosome 1 abnormalities. Translocation t(4;14) occurs in about 10% to 12% of newly diagnosed disease, but only patients with specific NSD2 alterations are, in fact, at risk of worse prognosis, which clinically appears to be about one in every three of those patients. And so together, the CoMMpass and Myeloma XI data suggest that translocation t(4;14) only in combination with deletion 1p or gain or amplification of 1q correlates with worse prognosis. Translocation t(14;20) occurs in only 2% of newly diagnosed disease. Similar to translocation t(4;14), it doesn't appear to have an effect on prognosis, except if the translocation co-occurs with chromosome 1 lesions, in which case patients do fare worse. Overall, these three translocations - t(14;16), t(4;14), and t(14;20) - should be considered high-risk only if chromosome 1 aberrations are also present. In terms of those chromosome 1 aberrations, category C, first deletions of 1p: Occurring in about 13% to 15% of newly diagnosed disease, deletion 1p eliminates critical cell checkpoints and normal apoptotic signaling. In the IFM and CoMMpass dataset analyses, biallelic deletion of 1p and monoallelic deletion of 1p co-occurring with additional copies of 1q denote high-risk. In terms of the other aberration in chromosome 1 possible in myeloma, gain or amplification of 1q: This occurs in up to 35% to 37% of newly diagnosed disease. It upregulates CKS1B, which is a cyclin-dependent kinase, and ANP32E, a histone acetyltransferase inhibitor. GEM and IFM data suggest that gain or amplification of 1q - there was no clear survival detriment to amplification - is best considered as a high-risk feature only in combination with the other risk factors as above. Now, in terms of any other criteria for high-risk disease, there remains one other item, and that has to do with tumor burden. There has been a consensus shift, really, in both the IMS and IMWG to attempt to develop a definition of high-risk disease which is based on biologic features rather than empirically observed and potentially temporally dynamic features, such as lactate dehydrogenase. Beta-2 microglobulin remains an independent high-risk indicator, but care must be taken when measuring it, as renal dysfunction can artificially inflate peripheral titers. The consensus conclusion was that a beta-2 microglobulin of at least 5.5 without renal failure should be considered high-risk but should not preclude detailed genomic profiling. So, in conclusion, the novel 2025 IMS-IMWG risk stratification system for myeloma is binary. It's either high-risk disease or standard-risk disease. It's got four criteria. Number one, deletion 17p and/or a TP53 mutation. Clonal cell fraction cut-off, remember, is 20%. Or number two, an IGH translocation - t(4;14), t(14;16), t(14;20) - with 1q gain and/or deletion of 1p. Or a monoallelic deletion of 1p with 1q additional copies or a biallelic deletion of 1p. Or a beta-2 microglobulin of at least 5.5 only when the creatinine is normal. This is a field-defining work that draws on analyses from across the world to put forward a dominant definition of high-risk disease and introduces a new era of biologically informed risk assessment in myeloma. Now, how does this change our clinical approach? FISH must be performed on CD138-enriched samples and should be performed for all patients. Next-generation sequencing should also be performed on all patients. Trials will hopefully now begin to include this novel definition of high-risk multiple myeloma. It does remain to be seen how data from novel therapeutic trials, if stratified according to this novel definition, will be interpreted. Will we find that therapies being evaluated at present have differential effects on myelomas with different genetic lesions? Other unanswered questions also exist. How do we go about integrating this into academic and then community clinical practice? How do we devise public health interventions for low-resource settings? To discuss this piece further, we welcome the esteemed Dr. Nikhil Munshi to the podcast. Dr. Munshi is a world-renowned leader in multiple myeloma and the corresponding author on this paper. As Professor of Medicine at Harvard Medical School, Director of the Multiple Myeloma Effector Cell Therapy Unit, and Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center of the Dana-Farber Cancer Institute, he has presided over critical discoveries in the field.  Thank you for joining us, Dr. Munshi. Dr. Nikhil Munshi: Oh, it's my pleasure being here, Michael, to discuss this interesting and important publication. Michael Hughes: I had a few questions for you. So number one, this is a comprehensive, shall we say, monumental and wide-ranging definition for high-risk myeloma. How do you hope this will influence or impact the ways we discuss myeloma with patients in the exam room? And how do we make some of these components recommended, in particular next-generation sequencing, feasible in lower-resource settings? Dr. Nikhil Munshi: So those are two very important questions. Let's start with the first: How do we utilize this in our day-to-day patient care setting? So, as you know well, we have always tried to identify those patients who do not do so well with the current existing treatment. And for the last 30 years, what constitutes a myeloma of higher risk has continued to change with improvement in our treatment. The current definition basically centers around a quarter of the patients whose PFS is less than 2 to 3 years. And those would require some more involved therapeutic management. So that was a starting point of defining patients and the features. As we developed this consensus amongst ourselves - and it's titled as “International Myeloma Society, International Myeloma Working Group Consensus Recommendation” - this IMS-IMWG type of recommendation we have done for many years, improvising in various areas of myeloma care. Now, here, we looked at the data that was existing all across the globe, utilizing newer treatment and trying to identify that with these four-drug regimens, with transplant and some of the immunotherapy, which group of patients do not do as well. And this is where this current algorithm comes up. So before I answer your question straight, “How do we use it?” I might like to just suggest, “What are those features that we have identified?” There are four features which constitute high-risk disease in the newer definition. Those with deletion 17p with 20% clonality and/or TP53 mutation. Number two, patients with one of the translocations - t(4;14), t(14;16), or t(14;20) - co-occurring with 1q amplification or deletion 1p32. And that's a change. Previously, just the translocation was considered high-risk. Now we need a co-occurrence for it to be called high-risk. The third group is patients having biallelic deletion 1p32 or monoallelic deletion 1p32 along with 1q amplification. And finally, patients with high beta-2 microglobulin, more than or equal to 5.5 mg/dL, with normal creatinine less than 1.2 mg/dL. And the question, “How do we use this?” There are multiple areas where we incorporate high-risk features in our treatment algorithm. One of the first areas is where we would consider the induction regimen. If a patient has a high-risk disease, we would definitely consider a four-drug regimen rather than a three-drug regimen, although we are beginning to incorporate four-drug for all groups. That's one important thing. Number two, those are the patients where we do consider consolidation with transplant or maybe in the new world, considering some of the immunotherapeutic consolidation more early or more aggressively. Number three, these are the patients who get a little bit more maintenance therapy. So normally, lenalidomide might end up being our standard maintenance regimen. In patients who have high-risk disease, we incorporate either addition of daratumumab or the anti-CD38 targeting antibody and/or addition of proteasome inhibitor, either bortezomib or carfilzomib. So you would have multi-drug maintenance therapy in these patients. And in high-risk patients, we follow them with maintenance longer periods of time. One very critically important point to keep in mind is that to get the better outcome in high-risk disease, we must try to get them into MRD negativity because there is clear data that patients who do achieve MRD negativity, despite having high-risk disease, have a much superior outcome. They become near to standard-risk disease. And so, in high-risk patients, I would try to do whatever various options I have to try and get them into MRD-negative status. And when these patients relapse, we do not wait for the classic progression criteria to be met before we intervene. We would propose and suggest that we intervene earlier before the disease really blasts off. And so there are a number of areas in our setting where this high-risk definition will help us intervene appropriately and also with appropriate aggressiveness to achieve better outcome, to make this similar to standard-risk disease. Michael Hughes: Thank you, Dr. Munshi. And thoughts on how to really integrate this not only into academic centers but also lower-resource settings? Dr. Nikhil Munshi: So that's a very important question, Michael. And when we were developing this consensus, we were very cognizant of that fact. So wherever available, I think we are recommending that over a period of next 2, 3, 5 years, we should begin to switch over to sequencing-based methods because two components of this definition, one is TP53 mutation, which we cannot do without sequencing, and also reliably detecting deletion 1p requires sequencing-based method. So in the low-resource countries - and there are many in this world, and also even in our own country, patients may not be able to afford it - the older method with FISH or similar such technology, which is more affordable, is also acceptable for current time. They may miss a very small number of patients, maybe 2% to 3%, where these finer changes are not picked up, but a majority of this would be captured by them. So the current practice might still be applicable with some limitation in those patient populations, and that's what we would recommend. What is happening, fortunately, is that actually sequencing-based method is becoming cheaper. And in many centers, it is cheaper to do the sequencing rather than to do the FISH analysis. And so my hope is that even in low-resource centers, sequencing might be more economical in the end. It's, I think, the access to technology, which is a little bit limited currently, but it's hopefully becoming available soon. Michael Hughes: Thank you, Dr. Munshi. And staying for a minute and looking at the multiple myeloma subsets which might be missed by this really still very broad-ranging high-risk definition, at least by prior risk stratification systems, right, there is this group of patients who have standard-risk cytogenetics by R-ISS or R2-ISS, but they have primary refractory disease or they relapse early. We call these, as you are well aware, functionally high-risk disease. What proportion of previously FHR, functionally high-risk, myeloma patients do you expect to be captured by this novel definition? Dr. Nikhil Munshi: So I think the newer definition - and we can look at it both ways, but the newer definition should capture most of the functionally high-risk definition. To put it differently, Michael, there are patients who we know are, as you mentioned, functionally high-risk. Those are the patients who might have plasma cell leukemia, those who might have extramedullary disease, those who might not respond to our four-drug induction. If you don't respond to the four-drug induction, almost by definition, they are high-risk. However, a majority of them have one of the abnormalities that we are describing here. There would be a very small proportion which may not have. And if they do not have, we know one of the important components of this definition here is also that the genome, we know, keeps on evolving. So there may be a very small clone with the high-risk feature which was not obvious in the beginning. Following treatments or following relapse, that clone predominates, and now the patient's disease becomes high-risk.  So the definition would incorporate or would capture these functional high-risk patients, but as you said, in countries where resources are not available, using this functional high-risk would also be helpful and advantageous. Sometimes LDH ends up being a high-risk. In our studies, LDH has not come out to be high-risk anymore because the features we are describing captures most of those patients, but those alternatives, older, can still be considered if other newer techniques are not available. Michael Hughes: Got you. And in terms of these older definitions, yes, that incorporate tumor burden, these empirical observations about how myeloma presents, do you foresee any additional tumor burden indicators being added to future definitions of high-risk disease? Or do you instead see this particular definition as a major waypoint on the journey towards a fully biologically grounded definition of high-risk disease? Dr. Nikhil Munshi: I think your second part is what is going to happen. I think the tumor burden-related definition is being now replaced by the biological or genomic-based definition. And I think at some point, it will be quite fully replaced. One component not here, and it is because one thing, we don't have enough data; number two, we don't know how it will pan out, is also the influence of the microenvironment on the risk definition. For example, the immune system, the immune function, etc. But not enough data exists to suggest how it would change the current definition. So in future, would a definition be totally genomic or it could be more integrative? And my personal guess is that it would be more integrative and that some immune features might come into the picture, especially now that we are using immune-based therapy as a very important component of treatment - CAR T-cells, bispecific, and antibody-based treatments. What role the immune system plays in either supporting tumor or what role suppression of the anti-tumor immunity plays? They all will be important how patient outcomes end up being, and which in turn could translate into how patient's risk stratification might happen. So I think the older tumor burden-related definitions probably will become things of the past. What we have currently proposed and consensus developed is the new path forward, and over time, some microenvironmental influences, if defined and found to be important, may get some more incorporation if it compares favorably with the genomic features. Michael Hughes: Thank you, Dr. Munshi for that enlightening response.  To conclude the podcast, I'd like to look to the future and to the immediate future, what are the next steps for high-risk disease definition between now and discussing an integrated genomic-microenvironment-based definition? Will we see attempts to refine? Will we see a multi-level system, things like this? Dr. Nikhil Munshi: Yeah, so I think the current definition will be here to stay for the next 10 years or so. I think this has been developed using a large amount of data, so we do believe that this will remain fine. It has been validated now within the last six months by a few of the other studies. So there won't be a quick change. But we will try to, all of us will try to innovate. And as you very rightly bring up, the areas of research would include looking at the expression or transcriptomic component. Does that matter? And we do believe a small number of patients will have transcriptomic changes, not looked at the DNA changes, and may play a role. There are newer components, so long non-coding RNA, for example, is going to be an important component to look at, how it impacts the disease outcome, etc. There are also some of the proteomic-related changes which may become important in our studies. And then as we discussed, microenvironment and immunological changes. So these are the future areas of ongoing research where we all should collect data, and then in the next 5 to 10 years, we'll have another group meeting to see has anything changed or any of the features have become more important.  Most of the time, some of the older features are lost because they are not as critically high-risk, and the newer features come in. And so the historical background for just one second, there was a time when chromosome 13 was considered a high-risk disease. We now don't even mention it because it's not high-risk. The newer treatments have improved the outcome. t(4;14) used to be a high-risk disease. Now by itself today, in this definition by itself is not; it needs to be with something else. And so I think this is a great sign of progress. As we improve the treatment and outcomes, some of the features will become less important, new features will come up, and we'll need to keep on evolving with time and with technology and make it better for patients. Michael Hughes: Thank you so much, Dr. Munshi, for your wisdom, for your sagacity, for your historical perspective as well.  Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries. And be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Paradigm Drift is the show where we celebrate theories, theorists, and freedom of thought. Each theorist gets 60 seconds to present their idea of the world, followed by an interview with us an our panelist. This week's episode was taped in Columbus, Ohio with Chris Ranney as panelist, Jay Smith on guitar, and Megan Ranney as supporting cast. Next one will be live in Portugal but you can sign up for the online version again in July: https://demystifysci.com/paradigm-drift-show. Theorists: Ricky Cisco, Matthew Fox, Lyndon Ashmore, Eugene Yashkin, Gary Barham, Jack Neefus, Bradie Lee, Ryan Mckenna, Wayne Coste, Michael Hughes, Sebastian SchepisMAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-show00:00 Go!00:02:05 – Ricky Cisco – Digital Archetypes and Predictive Systems00:12:05 – Matthew Fox – Vacuum Energy & the Cosmological Constant Problem00:24:10 – Lyndon Ashmore – Photon Energy Loss in the Intergalactic Medium00:34:09 – Eugene Yashkin– The Boiling Universe Hypothesis00:43:48 – Gary Barham – Composite Nature of Light: Photon and Gluon Duality00:53:06 – Jack Neefus – Solar Events and Earth's Rotational Axis Shift01:05:04 – Bradie Lee – Integrating Science and Spirituality Through Meditation01:14:00 – Ryan Mckenna– Real-Time Solutions to the Traveling Salesman Problem01:26:50 – Wayne Coste – Gravitational Asymmetry as the Cause of Cosmic Redshift01:39:00 – Michael Hughes – Water as the Bridge Between Science and Spirit01:56:11 – Sebastian Schepis – Consciousness, Entropy, and Prime Number Gravity Theory#philosophyofscience, #theoreticalphysics, #quantummechanics, #cosmology, #newideas, #scienceandspirituality, #openmic, #astrobiology, #consciousness, #philosophypodcast , #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasBMERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/allAMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysciBLOG: http://DemystifySci.com/blog RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

In this JCO Article Insights episode, host Michael Hughes summarizes "Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma" by Kaiser et al, published February 18, 2025, followed by an interview with JCO Associate Editor Suzanne Lentzsch. Transcript Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I have the privilege and pleasure of interviewing Dr. Suzanne Lentzsch on the “Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma” by Dr. Kaiser and colleagues. At the time of this recording, our guest has disclosures that will be linked in the transcript. The urge to identify patients with aggressive disease, which is the first step in any effort to provide personalized medical care, is intuitive to physicians today. Multiple myeloma patients have experienced heterogeneous outcomes since we first started characterizing the disease. Some patients live for decades after treatment. Some, irrespective of treatment administered, exhibit rapidly relapsing disease. We term this ‘high-risk myeloma'. The Durie-Salmon Risk Stratification System, introduced in 1975, was the first formal effort to identify those patients with aggressive, high-risk myeloma. However, the introduction of novel approaches in therapeutic agents—autologous stem cell transplantation with melphalan conditioning, proteasome inhibitors like bortezomib, or immunomodulatory drugs like lenalidomide—rendered the Durie-Salmon system a less precise predictor of outcomes. The International Staging System in 2005, predicated upon the burden of disease as measured by beta-2 microglobulin and serum albumin, was the second attempt at identifying high-risk myeloma. It was eventually supplanted by the Revised International Staging System (RISS) in 2015, which incorporated novel clinical and cytogenetic markers and remains the primary way physicians think about the risk of progression or relapse in multiple myeloma. Much attention has been focused on the canonically high-risk cytogenetic abnormalities in myeloma, typically identified by fluorescence in situ hybridization: translocation t(4;14), translocation t(14;16), translocation t(14;20), and deletion of 17p. Much attention also has been focused on the fact that intermediate-risk disease, as defined by the RISS, has been shown to be a heterogeneous subgroup in terms of survival outcomes. The RISS underwent revision in 2022 to account for such heterogeneity and has become the R2-ISS, published here in the Journal of Clinical Oncology first in 2022. Translocations t(14;16) and t(14;20) were removed, and gain or amplification of 1q was added. Such revisions to core parts of a modern risk-stratification system reflect the fact that myeloma right now is in flux, both in treatment paradigms and risk-stratification systems. The field in recent years has undergone numerous remarkable changes, from the advent of anti-CD38 agents to the introduction of cellular and bispecific therapies, to the very technology we use to investigate genetic lesions. The major issue is that we're seeing numerous trials using different criteria for the definition of high-risk multiple myeloma. This is a burgeoning problem and speaks very much now to a critical need for an effort to consolidate all these criteria on at least cytogenetic lesions as we move into an era of response-adapted treatment strategies. The excellent article by Kaiser and colleagues, published in the February 2024 edition of the JCO, does just that in a far-ranging meta-analysis of data from 24 prospective therapeutic trials. All 24 trials were phase II or III randomized controlled trials for newly diagnosed and relapsed/refractory multiple myeloma. The paper takes a federated analysis approach: participants provided summaries and performed prespecified uniform analyses. The high-risk cytogenetic abnormalities examined were translocation t(4;14), gain or amplification of 1q, deletion of 17p, and translocation t(14;16), if included in the original trials. All of these were collected into zero, single, or double-hit categories, not unlike the system currently present in diffuse large B-cell lymphomas. The outcomes studied were progression-free survival and overall survival, with these analyses adhering to modified ITT principles. The authors also performed prespecified subgroup analyses in the following: transplant-eligible newly diagnosed myeloma, transplant non-ineligible newly diagnosed myeloma, and relapsed/refractory myeloma. They, in addition, described heterogeneity by the I2 statistic, which, if above 50%, denotes substantial heterogeneity by the Cochrane Review Handbook, and otherwise performed sensitivity analyses and assessed bias to confirm the robustness of their results. In terms of those results, looking at the data collected, there was an appropriate spread of anti-CD38-containing and non-containing trials. 7,724 patients were evaluable of a total 13,926 enrolled in those 24 trials: 4,106 from nine trials in transplant-eligible myeloma, 1,816 from seven trials in transplant non-ineligible myeloma, and 1,802 from eight trials in relapsed/refractory disease. ISS stage for all patients was relatively evenly spread: stage I, 34.5%; stage II, 37%; stage III, 24%. In terms of high-risk cytogenetic lesions, double-hit disease was present in 13.8% of patients, and single-hit disease was present in 37.4%. In terms of outcomes, Kaiser and colleagues found a consistent separation in survival outcomes when the cohort was stratified by the number of high-risk cytogenetic lesions present. For PFS, the hazard ratio was for double-hit 2.28, for single-hit 1.51, without significant heterogeneity. For overall survival, the hazard ratio was for double-hit disease 2.94, single-hit disease 1.69, without significant heterogeneity except in patients with double-hit disease at 56.5%. By clinical subgroups, hazard ratios remained pretty consistent with the overall cohort analysis. In transplant-eligible newly diagnosed myeloma, the hazard ratio for progression is 2.53, overall survival 4.17. For transplant non-ineligible, 1.97 progression, 2.31 mortality. Relapsed/refractory disease progression 2.05, overall mortality 2.21, without significant heterogeneity. Of trials which started recruitment since 2015, that is to say, since daratumumab was FDA approved and thus since an anti-CD38 agent was incorporated into these regimens, analysis revealed the same results, with double-hit myeloma still experiencing worse survival by far of the three categories analyzed. Risk of bias overall was low by advanced statistical analysis. In terms of subgroup analysis, double-hit results for transplant-eligible newly diagnosed myeloma may have been skewed by smaller study effects, where the upper bound of the estimated hazard ratio for mortality reached into the 15 to 20 range. In conclusion, from a massive amount of data comes a very elegant way to think about the role certain cytogenetic abnormalities play in multiple myeloma. A simple number of lesions - zero, one, or at least two - can risk-stratify. This is a powerful new prognostic biomarker candidate and, somewhat soberingly, also may confirm, or at least suggests, that anti-CD38 agents are unable to overcome the deleterious impact of certain biologic characteristics of myeloma. Where do we go from here? This certainly needs further a priori prospective validation. This did not include cellular therapies. The very scale at which this risk-stratification system operates, agnostic to specific genetic lesion, let alone point mutations, lends itself also to further exploration. And to discuss this piece further, we welcome the one and only Dr. Suzanne Lentzsch to the episode. Dr. Lentzsch serves as an associate editor for JCO and is a world-renowned leader at the bleeding edge of plasma cell dyscrasia research. Dr. Lentzsch, there are several new investigations which suggest that translocation t(4;14), for example, is itself a heterogeneous collection of patients. There are other studies which suggest that point mutations in oncogenes like TP53, which were not assessed in Kaiser et al., carry substantial detrimental impact. Is this classification system - no-hit, single-hit, double-hit - too broad a look at tumor genetics? And how do you think we will end up incorporating ever more detailed investigations into the genetics of multiple myeloma moving forward? Dr. Suzanne Lentzsch: Michael, first of all, excellent presentation of that very important trial. Great summary. And of course, it's a pleasure to be here with JCO and with you to discuss that manuscript. Let me go back a little bit to high-risk multiple myeloma. I think over the last years, we had a lot of information on what is high-risk multiple myeloma, and I just want to mention a couple of things, that we separate not only cytogenetically high-risk multiple myeloma, we also have functional high-risk multiple myeloma, with an early relapse after transplant, within 12 months, or two years after start of treatment for the non transplant patients, which is difficult to assess because you cannot decide whether this is a high-risk patient before you start treatment. You only know that in retrospective. Other forms of high-risk: extramedullary disease, circulating tumor cells/plasma cell dyscrasia, patients who never achieve MRD positivity, extramedullary multiple myeloma, or even age and frailty is a high risk for our patients. Then we have gene expression and gene sequencing. So there is so much information currently to really assess what is high-risk multiple myeloma, that is very difficult to find common ground and establish something for future clinical trials. So what Dr. Kaiser did was really to develop a very elegant system with information we should all have. He used four factors: translocation t(14;16), t(4;14), gain or amplification of 1q, and deletion of 17p. Of course, this is not the entire, I would say, information we have on high risk, but I think it's a good standard. It's a very elegant system to really classify a standard single-hit, double-hit, high-risk multiple myeloma, which can be used for all physicians who treat multiple myeloma, and especially, it might also work in resource-scarce settings. So, ultimately, I think that system is an easy-to-use baseline for our patients and provides the best information we can get, especially with a baseline, in order to compare clinical trials or to compare any data in the future. Michael Hughes: Thank you, Dr. Lentzsch. To the point that you made about this isn't the full story. There does, as you said, exist this persistent group of functional high-risk multiple myeloma where we see standard-risk cytogenetics, but these patients ultimately either exhibit primary refractory disease or very early relapse despite aggressive, standard aggressive treatment. How do you see risk-stratification systems incorporating other novel biomarkers for such patients? Is it truly all genetic? Or is next-generation sequencing, gene expression profiling, is that the answer? Or is there still a role for characterizing tumor burden? Dr. Suzanne Lentzsch: Excellent question, Michael, and I wish I would have the glass ball to answer that question. I see some problems with the current approach we have. First of all, to do the cytogenetics, you need good material. You only detect and identify what you have. If the bone marrow is of low quality, you have mainly peripheral blood in your bone marrow biopsy, you might not really fully have a representation of all cytogenetic changes in your bone marrow. So I think with a low-quality sample, that you might miss one or the other really cytogenetic high risk. So, having said this, I think circulating tumor cells, that might be something we will look into in the future, because circulating tumor cells are readily available, can be assessed without doing a bone marrow biopsy. And what is even more exciting, in addition to the circulating tumor cells or plasma cells, using them is next-generation sequencing. I think at the moment, we are more in a collection phase where we really try to correlate sequencing with our cytogenetics and especially to establish next-generation sequencing in all of our patients. But I think after that collection phase, maybe in the future, collecting peripheral blood and doing sequencing on peripheral blood samples might be the way to go. In addition, I don't want to forget the imaging. We started with a skeletal survey, and we know that you probably need to lose 30% of the bone before you see a lesion at all. So having imaging, such as diffusion-weighted imaging, whole-body MRI, is also, together with sequencing of the tumor cells, a step into the right direction. Michael Hughes: Thank you, Dr. Lentzsch. Bringing this back to the article at hand, how has Kaiser et al. changed the way we discuss myeloma with patients in the exam room? Dr. Suzanne Lentzsch: I think we have more data on hand. So far, we talked about standard risk and high risk, but I think right now, with a very simple system, we can go into the room and we can tell the patient, "Listen, you don't have any of those cytogenetic abnormalities. I think you have a standard risk. We might give you a simple maintenance treatment with Revlimid." But we might also go into the room and say, "I'm really concerned. You have so-called double-hit multiple myeloma. You have high-risk and at least two of those abnormal cytogenetics which we discussed, and I think you need a more intense maintenance treatment, for instance, double maintenance." I think we know that a high-risk multiple myeloma can be brought into a remission, but the problem that we have is to keep those patients into a remission. So, I think a more intense treatment, for instance, with a double maintenance, or with consolidation after transplant, and a longer and more intense treatment is justified in patients who have that truly high-risk multiple myeloma described here. Michael Hughes: Dr. Lentzsch, thank you so much for your time and your wisdom. Dr. Suzanne Lentzsch: My pleasure. Thank you for having me. Michael Hughes: Listeners, thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries, and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit ASCO.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Michael Hughes is a postdoctoral researcher at St. Jude's Children's Hospital who studies the overlooked role of water in living systems. His work builds on a growing body of research suggesting that water is not just a passive solvent, but a highly structured, information-rich medium. Hughes proposes that under normal biological conditions, water's ability to form liquid crystalline phases, hydration shells, and coherent domains allows it to act more like an information storage system than an inert backdrop to biochemistry. Drawing on ideas like EZ water, interfacial water dynamics, and liquid-liquid phase separation inside cells that span thinkers from Gilbert Ling to Gerald Pollack, Hughes argues that health emerges from the fine-tuned electrical and structural properties of intracellular water. When this water-protein-electrical system breaks down, disease can result. He outlines a new approach to the body that's rooted in biophysics, not just molecular biology, which he believes might offer novel ways to maintain health and slow aging by restoring the electromagnetic coherence of the body.MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showPreprint of Michael's manuscript "Rethinking Cellular Organization: Phase Separation as a Unifying Principle in Molecular Biology" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5171413Dr. Thomas Seyfried podcast w/ DemystifyScihttps://www.youtube.com/watch?v=rxHkXP3G3y4"Live Streaming of a Single Cell's Life over a Local pH Monitoring Nanowire Waveguide" https://pubs.acs.org/doi/10.1021/acs.nanolett.2c02185Rudolf Steiner's Agriculture Course: https://www.youtube.com/watch?v=fwSa8Lpy9-A 00:00 Go! 00:09:54 – Water, Fields & the Electric Body 00:15:01 – Biochemistry's Unifying Principles 00:21:26 – Water, Glutamine & Metabolism 00:23:02 – Liquid-Liquid Phase Separation 00:25:34 – Hydration & Cellular Structure 00:28:08 – Amyloids in Health & Disease 00:33:52 – Environment Shapes Amyloids 00:39:37 – Osmosis, Metabolism & Flow 00:41:04 – Soil Over Seed: Health Revolution 00:42:24 – Evolving Scientific Paradigms 00:46:08 – Cell Theory & Liquid Separation 00:50:34 – Rethinking Genetic Primacy 00:56:12 – Biochemical Research Challenges 01:01:58 – Terrain Theory & Post-Pandemic Trust 01:13:16 – Technology, Ethics & Evolution 01:16:06 – Metabolism as Societal Metaphor 01:21:09 – Lifespan, Healthspan & Food Systems 01:23:25 – Terrain Theory & Neurodegenerative Disease 01:25:10 – pH, Buffers & Biochemical Balance 01:30:03 – Cellular Function & pH Dynamics 01:35:17 – Biochemical Cell Environment 01:39:06 – Intracellular Phase Separation 01:43:07 – Insulin, Gradients & Phase Transitions 01:45:12 – Water, Food & Environmental Impacts 01:48:14 – Personal Diet & Exercise Design 01:57:09 – Experimenting with Your Health 02:00:11 – Dyno comp! #electricuniverse #biochemistry, #structuredwater , #cellularhealth, #watermemory, #metabolism, #quantumhealth, #naturalmedicine, #integrativemedicine, #nutritionalscience, #epigenetics, #philosophypodcast, #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Invited theorists: Kehlan Morgan (Formscapes), Andrés Goméz Emilsson, Michael HughesRandom theorists: Edwin's Basye, Wendi Gardiner, Ricky Cisco, Philip Sportel, Jack Neefus, David de Hilster, Casey BrophyPanel: Kate Owlsley, Anastasia Bendebury, Michael Shilo DeLayLearn how to think, not what to think! Paradigm Drift is the show where we celebrate the principles of scientific anarchy. Anything goes, as long as you can make a coherent presentation about your theory and why you think it's going to change the world. Each theorist gets 60 seconds, followed by an interview with us and our panelist. MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFT:https://demystifysci.com/paradigm-drift-show(00:00) Go! (00:05:07) Kehlan Morgan on Formative Causation(00:16:36) Edwin's Basye's Proposal on Universal Nonviolence Law(00:25:49) Wendi Gardiner's Theory of Cancer(00:35:01) Ricky Cisco's Theory of Archetypes and Society's Evolution(00:47:18) Andrés Emilsson's Consciousness and Experience Theory(01:00:01) Philip Sportel's Information Scaling Framework(01:13:35) Michael Hughes' on Water's Piezoelectric Role in Cellular Identity(01:26:37) Jack Neefus' Structured Universe Theory(01:37:02) David de Hilster's Universal Particles Theory(01:49:10) Casey Brophy's Theory of Communication in the Cosmos(01:59:06) Next Paradigm Drift Plans(02:01:46) Recap, Night Cap#livepodcast, #ScientificTheories, #InnovativeIdeas, #moog #synth #philosophypodcast , #sciencepodcast, #longformpodcast PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasBMERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/allAMAZON: Do your shopping through this link: https://amzn.to/3YyoT98SUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics- Mailing list https://bit.ly/3v3kz2S - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss- Donate: https://bit.ly/3wkPqaD- Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Michael Hughes is a trailblazer in the luxury mattress industry, revolutionizing the way consumers experience organic sleep. As the Founder & CEO of PlushBeds, he built one of the largest direct-to-consumer brands specializing in toxin-free, eco-friendly mattresses. Inspired by his father's battle with Parkinson's, Michael set out to create a healthier sleep environment—one that blends sustainability with uncompromising comfort.With 25+ years in Ecommerce and direct selling, Michael transformed PlushBeds into a market leader, becoming one of the largest importers of organic latex in the U.S. His expertise spans product innovation, supply chain mastery, and direct-to-consumer growth strategies, allowing him to scale without sacrificing quality.Today, Michael is on a mission to redefine luxury sleep, ensuring that health-conscious consumers don't have to choose between comfort and sustainability. PlushBeds continues to set new standards in organic sleep solutions, proving that a commitment to quality and purpose-driven business can drive long-term success.In This Conversation We Discuss:[00:38] Intro[01:16] Introducing your brand to new audiences[01:49] Pivoting from finance to Ecommerce[06:47] Naming the brand with a simple idea[07:33] Studying competitors to find market gaps[11:44] Asking the right growth questions[12:32] Driving traffic with paid search & SEO[13:11] Testing orders before realizing it was real[14:36] Rebuilding after a devastating setback[15:30] Episode Sponsors: StoreTester and Intelligems[18:42] Analyzing competitors to stay ahead[19:39] Adopting AI but not mastering it yet[20:14] Adapting to an AI-native generation[21:03] Building a custom mattress-making machine[28:20] Listening to feedback to improve productsResources:Subscribe to Honest Ecommerce on YoutubeOrganic latex mattresses offer superior comfort & support plushbeds.com/Follow Michael Hughes linkedin.com/in/michael-hughes-plushbedsBook a demo today at intelligems.io/Done-for-you conversion rate optimization service storetester.com/If you're enjoying the show, we'd love it if you left Honest Ecommerce a review on Apple Podcasts. It makes a huge impact on the success of the podcast, and we love reading every one of your reviews!

Invited theorists: Ogi Ogas, Michael Hughes, David Ian Howe. Random theorists: James McGinn, Zarrin Leff, Austin Baldinger, Matthew Fox, Joe Cook, Shane SimonsenPanel: Doug Lee, Anastasia Bendebury, Michael Shilo DeLayLearn how to think, not what to think! Paradigm Drift is the show where we celebrate the principles of scientific anarchy. Anything goes, as long as you can make a coherent presentation about why your theory and why you think it's going to change the world. Each theorist gets 60 seconds, followed by an interview with us and our panelist. MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFT SIGN UP FOR 3/25, 6:30p PDT:https://demystifysci.com/paradigm-drift-showPATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasBMERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/allAMAZON: Do your shopping through this link: https://amzn.to/3YyoT98SUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci(00:00) Go! Welcome to Paradigm Drift #1(00:02:30) Ogi's Theory of Physics and Purpose(00:14:57) James' Theory Hydrogen Bonding Misunderstanding(00:26:28) Zarrin's Theory of Alexander the Great's Lost Tomb(00:36:48) Austin's Theory of Everything(00:46:45) Michael's Theory of Water as Bio-sensor & actuator(01:10:47) Matthew's Theory of Fine Structure Constant(01:14:10) Joe's Theory of Physical Dimensionality(01:30:33) Shane's Theory of Life's Double Origin(01:42:54) David's Theory of Cognitive Evolution and Tool-Making(01:57:26) Goodnight!#livepodcast, #ScientificTheories, #InnovativeIdeas, #CosmicCycle, #HydrogenBonding, #ArchaeologicalDiscoveries, #CellularBiology, #OsmoticPressure, #ExperimentalPhysics, #HistoricalMysteries, #AlternativeEnergy, #philosophypodcast , #sciencepodcast, #longformpodcastCheck our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomicsJoin our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss- Donate: https://bit.ly/3wkPqaD- Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Welcome to the 70th episode of the Full Stop Podcast! We're joined by returning guests Bindi Shah and Lisa Kissane, alongside co-hosts Berenice and Michael Hughes, for an inspiring conversation about setting intentions, goals, and how we navigate life as childless individuals. What We Discuss: Gentle Intentions vs. Rigid Goals: Lisa and Bindi contrast the pressures of goal-setting with the more flexible, empowering practice of setting intentions. Writing as Healing: Writing plays a pivotal role in self-expression and healing. From Bindi's poetry to Lisa's intention to write her first novel, we explore how creativity can unlock personal growth. Adapting to Life Challenges: How can we be kind to ourselves in the face of life's challenges? Michael opens up about family dynamics and the importance of taking life's reins, while Bindi highlights the transformative power of meditation. Seasons of Change: We discuss how the rhythm of the seasons—especially spring—can offer renewal and inspiration. Creating Safe Spaces: Lisa shares her intentions for “Flow,” her unique business community for childless and child-free individuals, providing a supportive environment away from parent-centric norms. Contact Lisa on Instagram, LinkedIn and via her website for Really Honest Business and Flow. Contact Bindi though her website and on her Youtube Channel: Soul Wisdom. Read her World Childless writing on adoption bias and watch her WCW webinar. Did you enjoy this episode? Join in the conversation in our Full Stop online community for childless people from £5 a month with a free month on us Buy a Virtual Coffee to keep our podcast ad free and accessible to everyone. Download Finding Connections, a booklet by Sarah and Berenice with links to groups, books, events and other resources for childless people. We hope you find it helpful. Join our newsletter for behind the scenes info, wellbeing tips and news from the wider community and alerts to our podcast as it publishes direct to your inbox.

Send us a textVideo Version HEREThis documentary uncovers the chilling true story of Hollywood icon Elke Sommer and her husband, Joe Hyams, as they faced one of the most compelling and bizarre paranormal hauntings you've likely never heard of. From mysterious sounds in the dining room to eerie apparitions, this spine-tingling case will leave you questioning the boundaries between the living and the dead.Why has this shocking story been left out of mainstream paranormal lore? In this video, we dive deep into the forgotten details of the haunting that gripped this glamorous couple's lives and explore their supernatural ordeal step by step. We also examine the investigations by renowned mediums, including Douglas Johnson, Baroness Lotte von Strahl, Michael Hughes, Maxine Bell, Brenda Crenshaw, and Jacqueline Eastlund and members of the ASPR (American Society for Psychical Research). LIFE magazine photographer Allan Grant and TV and Film actor Michael J Anderson, also experienced the paranormal at the house. If you're a fan of haunted Hollywood, true paranormal cases, or stories that defy explanation, don't miss this deep dive into a case that has gone unnoticed for far too long.Additional Voice Work byNathan Rouse, husband, dad, goofball, actor and podcaster, The Fear of God: https://www.thefearofgodpodcast.com/t...Tracy Nicholas (https://bsky.app/profile/folkloringpo...) from the Folkloring Podcast.https://www.folkloringpodcast.com/For more on Peter Laws check out:www.patreon.com/peterlawsor www.peterlaws.co.uk

Today we're back, for a third podcast, with long time friend of the pod, Dr. Michael Hughes - a biochemist at St. Jude's Research Hospital in Memphis, TN. We plunge into the secret story of water, revealing its role as more than a silent spectator in the dance of cellular processes. Like a conductor in an unseen ballet, water's dynamic and nuanced structures orchestrate communication across cells, acting as a transient computationally competent actuator. Michael reveals how much of this story has been buried for years under blanket abstractions like "pH" and electrochemistry. We see the emergence of a new paradigm in cellular computation, as we uncover how water may not just be the medium of life — at times it's perhaps every bit as alive as we are. PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB MERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/ AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98 References from Michael: Na+ vs K+ water dynamics: https://pubs.rsc.org/en/content/articlelanding/2017/sc/c6sc03320b ; https://pubmed.ncbi.nlm.nih.gov/23713450/ Ion pairing & Collins' Law of water affinity: https://doi.org/10.1017/S0033583519000106 Kosmotropes/Chaotropes ion pairing in biochemistry review: https://pmc.ncbi.nlm.nih.gov/articles/PMC4693242/ Osmotic pressure influences stem cell differentiation: https://www.pnas.org/doi/10.1073/pnas.1705179114 Hydration as a primary factor in carcinogenesis: https://pubmed.ncbi.nlm.nih.gov/16271440/ Distinguishing electrical properties of cancer cells: https://www.sciencedirect.com/science/article/abs/pii/S157106452200063X Heart is not a pump: https://rsarchive.org/OtherAuthors/MarinelliRalph/marinelli1.html Laszlo Boros water metabolism: https://www.youtube.com/watch?v=0g8OLChXta8 (00:00) Go! (00:09:24) Revisiting Water's Unknowns in Biology (00:22:44) Osmotic Pressure as Dark Matter (00:30:38) Water Molecule Interactions (00:35:37) Collective Motion and Electricity (00:44:35) Memory of Water, for Real (00:48:09) Disappearing Polymorphs and Chemical Synthesis (00:51:05) Understanding Water Freezing and Supercooling (00:59:05) pH, Charge, and Biological Systems (01:08:38) Tetrahedral Ordering in Water Structures (01:17:01) Energy Transfer and Cellular Connectivity (01:30:00) Back to pH (01:39:10) Cosmotropes and Chaotropes (01:49:57) Ion Dynamics in Cells (01:57:15) Unconventional Views on Consciousness and Physiology #water , #structuredwater , #paradigmshift , #Biochemistry, #ScienceExplained, #Electrochemistry, #NewParadigm, #WaterInBiology, #CellularCommunication, #PhaseTransitions, #Biophysics, #MolecularScience, #SciencePodcast, #ScientificBreakthrough, #WaterStructure, #EmergingScience, #CellBiology, #BiochemicalMysteries, #pHExplained, #scientificinnovation #sciencepodcast, #longformpodcast Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671

Just before the LodeStar team hits the road and heads out to MBA Annual in Denver, CO, Alayna sits down with LodeStar's National Sales Representative, Michael Hughes, a Denver local, to talk about the conversations that matter most.

The Young'uns are three award winning troubadours from Teeside. Sean Cooney, David Eagle and Michael Hughes take Matthew Bannister on a walk round the historic headland of Hartlepool where Sean used to live in a shed in his parents' back garden. Along the way they tell stories and sing songs inspired by the location, visiting the medieval Sandwell Gate, St Hilda's Church and the Heugh Battery, site of the only First World War battle to take place on British soil. They end up in the Pot House pub, where the Young'uns used to run a folk club, singing Cooney's original composition “The Hartlepool Pedlar”. There may also be time for a pint.---We rely on support from our listeners to keep this show on the road. If you like what we do please either...Become a member and get great rewards: patreon.com/folkonfootOr just buy us a coffee: ko-fi.com/folkonfootSign up for our newsletter at www.folkonfoot.comFollow us on Twitter/Facebook/Instagram: @folkonfoot---Find out more about the Young'Uns at https://www.theyounguns.co.uk/ Hosted on Acast. See acast.com/privacy for more information.

A young woman's body was found on the side of the road in Choctaw, OK in 1990. Four years after her death, her son, Michael Hughes, was abducted from his elementary school by a man who claimed to be his father. Who was the young woman and what happened to her son? Her death and her son's disappearance would lead to a string of disturbing discoveries over the following two decades. Check it out!!! Tons of bonus content from Generation Why available at: patreon.com/generationwhyListen ad free with Wondery+. Join Wondery+ for exclusives, binges, early access, and ad free listening. Available in the Wondery App. https://wondery.app.link/generationwhy.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This is Dr. Hughes second appearance on the podcast. His background is in biochemistry and biophysics of protein folding, and water hydration structures. But today we're digging under the floorboards of science itself. Is it possible to have a science that isn't built on some set of assumed values? To tackle this issue, we dig into esoteric mysticism - particularly the work of Rudolph Steiner, who prophesized many of the features of the world we see today back in the late 19th century. This leads us to a path where we explore the modern scientific approach to understanding nature, grounded in materialism in all its splendor and shortcomings, asking where do we go from here? What does a healthy science of the future actually look like? Tell us your thoughts in the comments! Sign up for our Patreon and get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB REFERENCES FROM THIS PODCAST: Remote viewing archeology w/ Stephen Schwartz https://www.youtube.com/watch?v=KwcEyflmaxk Tom Campbell Interview with Curt Jaimungal https://www.youtube.com/watch?v=kko-hVA-8IU Tom's home page: https://www.my-big-toe.com/ Dolores Cannon https://en.wikipedia.org/wiki/Dolores_Cannon Gigi Young Esoteric keys to disclosure: https://www.youtube.com/playlist?list=PLpGFUcLNHueY9of3kmOxpjok_aNGx_Z6W Rudolf Steiner Archives: https://rsarchive.org/Volumes.html New thinking aloud: https://www.youtube.com/watch?v=ZX4j4qBsqyk Bashar/Darryl Anka https://www.bashar.org/about Interview w/ Danica Patrick: https://www.youtube.com/watch?v=qCtvgJG1I5A CIA gateway/interview with remote viewer on Shawn Ryan show? CIA gateway tapes https://www.youtube.com/watch?v=XRTon6qgVws Ways of being by James Bridle https://jamesbridle.com/books/ways-of-being 00:00 Go! 00:05:39 Genetics Alchemy vs Structural Biology Mechanism 00:15:44 A natural mechanism that's distinct from science 00:21:07 Scientific literature as esoterica 00:30:10 Is scientific myth-making meaningful? 00:36:14 Science as a way of putting order to pure chaos 00:44:29 A full theory of nature has to contain more than science 00:52:13 Can science pinpoint the source of ideas, inspiration, and instinct? 01:01:00 Rudolph Steiner's spiritual science 01:10:40 preference for sensation as a driver of evolution 01:19:34 Religious allegory as an evolutionary roadmap? 01:29:41 A fracturing of evolutionary paths - technological, spiritual, material 01:41:00 The arc of dematerialization over the course of a lifetime 01:44:41 The immaterial vs the material, the crisis of our time? 01:53:29 Where is the source of misanthropy? 02:05:46 Stay awake 02:14:40 Reconciling a desire for Newtonian outcomes with the chaos of possibility 02:25:30 Closing thoughts Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671

May 26th: Verna Williams Discovered Dead (Michael Hughes)(1986) Los Angeles, during the late 80s and early 90s, was a truly terrifying place to live with victims of violent crimes that seemed to turn up almost daily. On May 26th 1986 one such victim was found and, though it would take a few decades, her case would land amongst many others all connected to one dangerous man. https://en.wikipedia.org/wiki/Michael_Hughes_(serial_killer)#:~:text=Verna%20Williams%2C%2036%2C%20was%20discovered,Lonnie%20David%20Franklin%20Jr.)., https://murderpedia.org/male.H/h/hughes-michael.htm, https://homicide.latimes.com/post/verna-williams/, https://www.dailynews.com/2008/07/03/convict-appears-in-court-in-cold-case-killings/, https://www.sfgate.com/bayarea/article/Convicted-serial-killer-faces-more-charges-3206717.php, https://www.upi.com/Archives/1986/07/26/Prostitute-slayer-may-have-claimed-18th-victim/4178522734400/, https://www.ourweekly.com/2012/06/22/convicted-serial-killer-sentenced-to-death/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, CEO and Founder of Gymnazo, Michael Hughes discusses the future of boutique fitness, highlighting trends, innovations, and strategies in the industry. He emphasized the importance of movement training, personalized care, and sustainable scalability. Michael also discussed the challenges of growing a team in the health and fitness industry and the need for trainers to adapt to the growing trend of boutique services. Additionally, he shared his insights on establishing a long-lasting career as a personal trainer, emphasizing the importance of offering more than the standard quo, prioritizing personal and professional growth, setting clear goals, and creating a well-defined action plan.Shownotes:0:52 Future of boutique fitness industry with insights from industry leaders. 6:13 Personal training career sustainability and growth.11:14 Movement as medicine, gym business models, and the importance of muscle building for overall health.15:51 Setting goals and creating a plan for success in the fitness industry.21:23 Growing a team in the fitness industry, challenges and solutions.26:33 Fitness industry trends, focusing on blending restoration with exercise.30:43 The growth of boutique fitness and the need for trainers to provide sustainable, impactful coaching.35:42 Industry trends and the need for movement coaches.Work with UsBecome a Multi-Dimensional Movement Coach - join this 6-month mentorship program that will teach you the foundational principles of movement and equip you with the skills and confidence to take your training and client result to the next level. Attend the Functional Movement Workshop August 10-11 in San Luis Obispo, CA - unlock your creativity, enhance your client results and bring more function to your programming in this 2-day workshop. Learn how to lead a restoration-based group class - in this free PDF, get the outline for how to lead your clients through a 45-minute restorative session that utilizes foam rolling, stretching and light functional movement, leaving them feeling refreshed, revitalized and oftentimes pain-free. Follow UsInstagram: @gymnazo_eduYoutube: Gymnazo EDUFacebook: Gymnazo EDUTikTok: @gymnazoedu

In this episode, CEO and Founder of Gymnazo, Michael Hughes discusses the future of boutique fitness, highlighting trends, innovations, and strategies in the industry. He emphasized the importance of movement training, personalized care, and sustainable scalability. Michael also discussed the challenges of growing a team in the health and fitness industry and the need for trainers to adapt to the growing trend of boutique services. Additionally, he shared his insights on establishing a long-lasting career as a personal trainer, emphasizing the importance of offering more than the standard quo, prioritizing personal and professional growth, setting clear goals, and creating a well-defined action plan.Shownotes:0:52 Future of boutique fitness industry with insights from industry leaders. 6:13 Personal training career sustainability and growth.11:14 Movement as medicine, gym business models, and the importance of muscle building for overall health.15:51 Setting goals and creating a plan for success in the fitness industry.21:23 Growing a team in the fitness industry, challenges and solutions.26:33 Fitness industry trends, focusing on blending restoration with exercise.30:43 The growth of boutique fitness and the need for trainers to provide sustainable, impactful coaching.35:42 Industry trends and the need for movement coaches.Work with UsBecome a Multi-Dimensional Movement Coach - join this 6-month mentorship program that will teach you the foundational principles of movement and equip you with the skills and confidence to take your training and client result to the next level. Attend the Functional Movement Workshop August 10-11 in San Luis Obispo, CA - unlock your creativity, enhance your client results and bring more function to your programming in this 2-day workshop. Learn how to lead a restoration-based group class - in this free PDF, get the outline for how to lead your clients through a 45-minute restorative session that utilizes foam rolling, stretching and light functional movement, leaving them feeling refreshed, revitalized and oftentimes pain-free. Follow UsInstagram: @gymnazo_eduYoutube: Gymnazo EDUFacebook: Gymnazo EDUTikTok: @gymnazoedu

Among the missing persons cases online sleuth Todd Matthews followed were that of two boys from the same family who vanished 25 years apart. He was shocked to receive a call from a man who thought he might be Phillip Steven Brandenburg, the baby who went missing in 1974.Todd determined Steve Patterson was indeed the John Doe they'd been searching for and helped him reconnect with the mother he never knew. Sandi Brandenburgh claimed the underground adoption was brokered by her husband. Soon after, Franklin Floyd disappeared with Sandi's oldest daughter and lived on the run with her for years. Authorities would not tie all these threads together until three more people were dead or missing.From iHeartMedia, Revelations Entertainment, First and Last Productions, and Neon Hum Media, comes "Hello, John Doe." We hear Todd work with Steve to learn more about where he came from, though the answers are discouraging. It also guides listeners through the connections to the Sharon Marshall and Michael Hughes cases and Todd's efforts to reunite a family torn apart by tragedy.OUR SPOILER-FREE REVIEWS OF "HELLO, JOHN DOE" BEGIN IN THE FINAL 10 MINUTES OF THE EPISODE. For exclusive podcasts and more, sign up at Patreon.Sign up for our newsletter at crimewriterson.com

What if your anti-financial crime program could build investigation models using sensitive data you may not have direct access to – in a totally compliant way? In this episode, we learn from Privacy Enhancing Technology (PET) expert, Michael Hughes, Chief Business Offer at Duality Technologies, about the potential PETs have to change the game of KYC.Follow along as Michael and host, Alex Pillow, discuss all things PETs, exploring topics like:The value PETs could bring to the world of AFCPrivacy rights of an individual vs. useful data for institutionsVarious PET use casesHow regulatory bodies feel about the rise of PETsIndustry sectors that have become early adopters of PETs (the answer may surprise you)For additional resources mentioned in this episode, check out the links below on Duality's website:Zero footprint investigationsCollaborative AIVisit our website to learn how Moody's Compliance and third-party risk management can take AFC in your organization to the next level, and please feel free to get in touch – we'd love to hear from you!

Get your DEMYSTICON 2024 tickets here: https://www.eventbrite.com/e/demysticon-2024-tickets-727054969987 Today we are hanging out with our friend Dr. Michael Hughes, a post-doctoral fellow at St. Jude's Research Hospital in Memphis. Michael has a long history of trying to understand the role that water plays in fundamental biological operations from structural assembly to diseases like Alzheimers and Prion disorders. Presently, he is hard at work on a biological theory of everything where water plays out the role of central actor in biological processes from form to consciousness. Our conversation today begins with Michael's journey into the water rabbit hole, exploring the strange way that water structures itself within cells. We work toward an understanding of water as a photo-electrically, an electro-statically sensitive molecule capable of mechanically altering cellular function in response to conscious and external signals. We hope to have Michael back to explore a mutual fascination with the historic interface of spirituality and science by way of Rudolph Steiner and Western esotericism. Tell us your thoughts in the comments!!! Sign up for a yearly Patreon membership for discounted conference tickets: https://bit.ly/3lcAasB Gilbert Ling's website & books: https://www.gilbertling.org/books.html Modern review based on the Association Induction Hypothesis: https://pubmed.ncbi.nlm.nih.gov/32565181/ Rice University Archives of the Impossible: https://libguides.rice.edu/impossiblearchives (00:00) Go! (00:09:25) APS 2024 (00:11:01) Biochemistry to Cell Biology to Water Physics (00:12:49) Math has true answers (00:16:21) Prions, amyloids (00:25:49) Stress granules as proto-organelle (00:32:38) Aging as disease or no? (00:44:08) Water as biological theory of everything (00:57:19) Transient h-bonding structures (01:15:11) Water density as biological master switch? (01:26:41) Water as dark matter of consciousness (01:40:13) UAPs to be taken seriously? (01:54:36) Evidence-based beliefs? (02:11:43) Remote viewing (02:28:10) Science without spirituality? #science #sciencepodcast #BiologicalResearch #WaterInScience #ConsciousnessStudies #CellularFunction #MedicalScience #StJudesResearch #Biochemistry #AlzheimersResearch #PrionDisorders #ScienceAndSpirituality #PodcastInterview #MedicalInnovation #ResearchInsights #ScienceCommunication #HealthAndWellness #WaterMolecule #StructuralBiology #ConsciousnessExploration #SpiritualScience #SciencePodcast #structuredwater #waterscience #waterchemistry Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671

Gymnazo's Michael Hughes and CJ Kobliska join CJ to highlight Gymnazo's story and talk about their passion for personal fitness!   Check out @gymnazo_edu and @3d_athlete on Instagram! Thanks to all my partners: Dr. Daniel Lapidus & Larry Ackerman, Dr. Brad Kurgis of Kurgis Dermatology, California Fresh Markets, The SLO Wellness Center, Avila Bay Athletic Club & Spa, Joy of Shell Beach,  Michael Moore Sports Recovery, Gymnazo, and SLO Big Brothers Big Sisters.

Welcome to the Gymnazo Podcast! In this episode, join us as we delve into the core skills every personal trainer needs to succeed in the competitive fitness industry. Our host and Founder of Gymnazo, Michael Hughes, a renowned expert in fitness entrepreneurship, shares invaluable insights and proven strategies to help personal trainers elevate their game and stand out in today's dynamic market.Michael dives deep into the essential skills that set top-tier personal trainers apart. From conducting comprehensive movement assessments to effectively addressing musculoskeletal dysfunctions, they leave no stone unturned. Learn how to master communication, deliver exceptional customer service, and craft sustainable training programs that yield remarkable results for your clients.Discover the importance of understanding client needs and goals, and gain valuable insights into tackling movement pain and musculoskeletal disorders. Michael sheds light on the limitations of traditional assessment methods and introduces innovative techniques for achieving optimal client outcomes.Moreover, this episode explores the nuances of client motivation and communication, delving into the psychology of personality types and their communication styles. Gain practical tips on tailoring your coaching approach to different personalities, and creating personalized training experiences that drive client satisfaction and loyalty.Whether you're a seasoned fitness professional or just starting out, this episode equips you with the tools and strategies you need to thrive in the competitive world of fitness training. Tune in now and unlock the secrets to success with Michael Hughes on the Gymnazo Podcast!Resources: If you want to learn more about the Multi-Dimensional Movement Coach (MDMC) Mentorship, check this out. If you want to join us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a 3D Movement Workshop even April 20-21, 2024. Tickets are $299 (unless you're a MDMC student or grad, then it's free!)Links: Connect with us on Instagram. Connect with us on Tiktok.

Welcome to the Gymnazo Podcast! In this episode, join us as we delve into the core skills every personal trainer needs to succeed in the competitive fitness industry. Our host and Founder of Gymnazo, Michael Hughes, a renowned expert in fitness entrepreneurship, shares invaluable insights and proven strategies to help personal trainers elevate their game and stand out in today's dynamic market.Michael dives deep into the essential skills that set top-tier personal trainers apart. From conducting comprehensive movement assessments to effectively addressing musculoskeletal dysfunctions, they leave no stone unturned. Learn how to master communication, deliver exceptional customer service, and craft sustainable training programs that yield remarkable results for your clients.Discover the importance of understanding client needs and goals, and gain valuable insights into tackling movement pain and musculoskeletal disorders. Michael sheds light on the limitations of traditional assessment methods and introduces innovative techniques for achieving optimal client outcomes.Moreover, this episode explores the nuances of client motivation and communication, delving into the psychology of personality types and their communication styles. Gain practical tips on tailoring your coaching approach to different personalities, and creating personalized training experiences that drive client satisfaction and loyalty.Whether you're a seasoned fitness professional or just starting out, this episode equips you with the tools and strategies you need to thrive in the competitive world of fitness training. Tune in now and unlock the secrets to success with Michael Hughes on the Gymnazo Podcast!Resources: If you want to learn more about the Multi-Dimensional Movement Coach (MDMC) Mentorship, check this out. If you want to join us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a 3D Movement Workshop even April 20-21, 2024. Tickets are $299 (unless you're a MDMC student or grad, then it's free!)Links: Connect with us on Instagram. Connect with us on Tiktok.

Join Gymnazo Founders, Paden and Michael Hughes in this enlightening episode as we delve into the journey of Michael, a kinesiology graduate turned successful personal trainer and 7 figure gym owner. We address a burning question in the fitness industry: when is the right time to invest in your education as a personal trainer? Discover how to identify your knowledge gaps and explore the most effective educational pathways to establish a solid foundation for your expertise.We dissect the crucial disparity between quick-fix weekend certifications focused on single modalities and the invaluable depth offered by comprehensive systems that integrate scientific principles with the intricacies of human physiology. Plus, don't miss out on an exclusive preview of our forthcoming program, the MultiDimensional Movement Coach Mentorship, designed to empower fitness professionals like you to excel in a dynamic and multidimensional fitness landscape.Tune in for invaluable insights, practical tips, and a glimpse into the transformative potential of holistic education in the fitness industry. Whether you're a seasoned personal trainer or just embarking on your fitness career, this episode is packed with actionable wisdom to elevate your journey to the next level.Resources: If you want to learn more about the MultiDimensional Movement Coach (MDMC) Mentorship, check this out. If you want to join us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a 3D Movement Workshop even April 20-21, 2024. Tickets are $299 (unless you're a MDMC student or grad, then it's free!)Links: Connect with us on Instagram. Connect with us on Tiktok.

Join Gymnazo Founders, Paden and Michael Hughes in this enlightening episode as we delve into the journey of Michael, a kinesiology graduate turned successful personal trainer and 7 figure gym owner. We address a burning question in the fitness industry: when is the right time to invest in your education as a personal trainer? Discover how to identify your knowledge gaps and explore the most effective educational pathways to establish a solid foundation for your expertise.We dissect the crucial disparity between quick-fix weekend certifications focused on single modalities and the invaluable depth offered by comprehensive systems that integrate scientific principles with the intricacies of human physiology. Plus, don't miss out on an exclusive preview of our forthcoming program, the MultiDimensional Movement Coach Mentorship, designed to empower fitness professionals like you to excel in a dynamic and multidimensional fitness landscape.Tune in for invaluable insights, practical tips, and a glimpse into the transformative potential of holistic education in the fitness industry. Whether you're a seasoned personal trainer or just embarking on your fitness career, this episode is packed with actionable wisdom to elevate your journey to the next level.Resources: If you want to learn more about the MultiDimensional Movement Coach (MDMC) Mentorship, check this out. If you want to join us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a 3D Movement Workshop even April 20-21, 2024. Tickets are $299 (unless you're a MDMC student or grad, then it's free!)Links: Connect with us on Instagram. Connect with us on Tiktok.

This week Beth and Wendy discuss the case of Michael Hughes, a convicted serial killer who killed at least 7 women between 1986 and 1993. He was actually one of at least five active serial killers in Los Angeles at the time that claimed the lives of more than 50 young black women. This episode was researched & scripted by Wendy & Beth Williams and edited by Minnie Williams. Thanks for listening! This is a weekly podcast and new episodes drop every Thursday, so until next time... look alive guys, it's crazy out there! Shout Outs The Opportunist (podcast) The Railway Men: The Untold Story Of Bhopal 1984 (Netflix series) Where to find us: Our Facebook page is Fruitloopspod and our discussion group is Fruitloopspod Discussion on Facebook; https://www.facebook.com/groups/fruitloopspod/ We are also on Twitter and Instagram @fruitloopspod Please send any questions or comments to fruitloopspod@gmail.com or leave us a voicemail at 602-935-6294. We just might read your email or play your voicemail on the show! Want to Support the show? You can support the show by rating and reviewing Fruitloops on iTunes, or anywhere else that you get your podcasts from. We would love it if you gave us 5 stars! You can make a donation on the Cash App https://cash.me/$fruitloopspod Or become a monthly Patron through Patreon patreon.com/user?u=11415202 Footnotes: Music “Abyss” by Alasen: ●https://soundcloud.com/alasen●https://twitter.com/icemantrap ●https://instagram.com/icemanbass/●https://soundcloud.com/therealfrozenguy● Licensed under Creative Commons: By Attribution 3.0 License “Trap Hamza” by Arulo Mixkit Stock Music Free License https://mixkit.co/free-stock-music/trap/ “Traffic” by Kai Engel Free Music Archive http://freemusicarchive.org/music/Kai_Engel/ “Starz” by Yung Kartz https://freemusicarchive.org/music/Yung_Kartz Licensed under Creative Commons: By Attribution 4.0 License “Furious Freak” by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3791-furious-freak License: http://creativecommons.org/licenses/by/4.0/ Connect with us on: YouTube: https://www.youtube.com/channel/UCQHgsKYPbzsI4AEiMrUgabA Twitter @FruitLoopsPod Instagram https://www.instagram.com/fruitloopspod Facebook https://www.facebook.com/Fruitloopspod and https://www.facebook.com/groups/fruitloopspod Learn more about your ad choices. Visit megaphone.fm/adchoices

It's been way too long, but the Backlog Bingo Brunch gang is back in business. This is the first part of the return that we recorded at 8 AM (which evidently is too early for some people). Mathman and BlazeKnight were joined by Michael Hughes to discuss how their gaming has been going this year since we last talked back in March. Michael - Spider-Man 2, Backpack Hero, Neon Abyss, Alan Wake 2, Dordogne Mike - Thirsty Suitors Ryan - Forza Horizon 5, Like a Dragon: Gaiden Join the Backlog Busters on Discord: https://discord.gg/qSubKhqn⁠ Connect with the Backlog Busters on Twitter ⁠@Backlog_Busters⁠.  You can also follow the voices you heard: Ryan - ⁠@mathman1024⁠ Mike - ⁠@blazeknight0923⁠ Michael - ⁠@KaidanXain⁠

You'll love these player interviews from the 2023 Michael Hughes Eau Claire, WI Squirt Hockey Tournament!Williams Diamond Center Williams Diamond Center is a fun and friendly place to find your next sparkling signature pieceEau Claire Ford Eau Claire Ford is here for all your parts and service needs for your vehicleDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.@TheBOSPodwww.thebreakoutsessions.com

FULL SHOW NOTES: https://haileyrowe.com/coach-with-confidence Join my free Facebook community for business support & to connect with other health coaches: https://www.facebook.com/groups/themarketinghubgroup/ Facebook: https://www.facebook.com/haileyrowecoach Instagram: https://www.instagram.com/hailey_rowe Twitter: https://www.twitter.com/hailey_rowe

We end the Previews for Strange Realities 2023 with three more presenters at the conference Timothy Renner, Michael Hughes, and Seriah Azkath.Tickets are still available for Strange Realities 2023 at: https://www.eventbrite.com/e/strange-realities-conference-2023-tickets-629622185907?aff=oddtdtcreatorSupport this podcast at — https://redcircle.com/conspirinormal-podcast/donationsThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/4656375/advertisement

We end the Previews for Strange Realities 2023 with three more presenters at the conference Timothy Renner, Michael Hughes, and Seriah Azkath.Tickets are still available for Strange Realities 2023 at:https://www.eventbrite.com/e/strange-realities-conference-2023-tickets-629622185907?aff=oddtdtcreatorSupport this podcast at — https://redcircle.com/conspirinormal-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Kyle hops on the podcast with Michael Hughes, Chief Commercial and Revenue Officer at ChargePoint, to discuss the latest news at the company regarding their NACS retrofit plans! Kyle and Michael go into detail about the NACS connector support for both AC and DC solutions that ChargePoint is now rolling out, the future of NACS at the company, how they plan to work with site hosts to decide the best next step for them and their needs, plus more technical and big picture details surrounding this news.ChargePoint Press Release: https://www.chargepoint.com/about/news/chargepoint-ramps-production-tesla-compatible-nacs-ev-chargersFind us on all of these places:YouTube: https://www.youtube.com/outofspecpodcastApple Podcasts: https://podcasts.apple.com/us/podcast/out-of-spec-podcast/id1576636119Spotify: https://open.spotify.com/show/0tKIQfKL9oaHc1DLOTWvbdAmazon: https://music.amazon.com/podcasts/473692b9-05b9-41f9-9b38-9f86fbdabee7/OUT-OF-SPEC-PODCASTFor further inquiries please email podcast@outofspecstudios.com Hosted on Acast. See acast.com/privacy for more information.

My good buddy Michael Hughes is my guest this week! Michael is an amazingly well-rounded weirdo: Forteanna, tarot, magic, esoteric studies and a ton more. We delved into a wide range of topics including his massively viral Donald Trump binding spell, bigfoot as a Western folk hero,  and...the time he was in a John Waters film! Enjoy the episode, and have a great week!Michael Hughes Info:https://www.michaelmhughes.com/https://twitter.com/michaelmhughes

Our radio crew recaps the Mountaineers road win over ULM to open conference play, as Michael Hughes drilled a 54-yard field goal as time expired in a 41-40 victory. Listen back to all of the highlights and hear the postgame thoughts of Hughes, Kaedin Robinson, and head coach Shawn Clark.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Michael Hughes is here talking about the 2 day blood drive at the Claremont Senior Center Aug 28 & 29th.  We talk about how appointment numbers are down, walk ins are welcome this year, what the goal is and more.

Today is a returning guest, Dr. Michael Hughes. In our discussion we talk about 2 topics. One is on the kidneys and how it affects scleroderma patients and the 2nd topic is on neurological problems and neuromuscular manifestations associated with scleroderma. It was another great conversation and I learned so much. For more background information on Dr. Hughes, you can either go back to episode 39 or go to my website. 

We try to do many games on this show and sometimes they are even games My Mom did find.  This time we go back to the 90s to play a SNES RPG for beginners.  one that gets overlooked and dosent get the appreciation it deserves.  Come listen to us deep dive into Final Fantasy Mystic Quest. Starring Mike Albertin, Blake Anglin, and Michael Hughes. A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC Final Fantasy Spirits Within (Film 60) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/final-fantasy-spirits-within-film-60-gmmf Final Fantasy 8 - GMMF 224 https://gamesmymomfoundpodcast.podbean.com/e/final-fantasy-8-gmmf-224 Final Fantasy 6 - GMMF 150 https://gamesmymomfoundpodcast.podbean.com/e/final-fantasy-6-gmmf-150 Dirge of Cerberus: Final Fantasy 7 - GMMF 112 https://gamesmymomfoundpodcast.podbean.com/e/dire-of-cerberus-final-fantasy-7-gmmf-112  

Description: Join us on this episode as we delve into the inspiring story of Gymnazo, a unique fitness venture that seamlessly blends restorative techniques with athletic performance. We sit down with the founder, Michael Hughes, a visionary who turned his childhood passion for sports and strength training into a revolutionary fitness methodology. We'll explore Michael's early days in San Luis Obispo (SLO), where he started his career as a personal trainer, handing out business cards at Kennedy Club Fitness. We'll discuss his relentless pursuit of knowledge, which led him to the Fellowship of Applied Functional Science and the influential work of Gary Gray. Discover how Michael's vision of integrating restoration strategies and three-dimensional movement into workouts came to life, starting with just 18 athletes and growing into the thriving Gymnazo community. We'll also discuss the crucial role of Paden, Michael's partner in life and business, who brought her passion for marketing and business growth to Gymnazo, allowing Michael to focus on innovation and team building. This episode is a deep dive into the origins of Gymnazo, the challenges and triumphs of entrepreneurship, and the power of a strong vision. Whether you're a fitness enthusiast, an aspiring entrepreneur, or someone who loves a good success story, this episode has something for you. Tune in to hear how Michael and Paden are changing the fitness landscape, one movement at a time. Disclaimer: Not advice. Educational purposes only. Not an endorsement for or against. Results not vetted. Views of the guests do not represent those of the host or show. Do your due diligence. Click here to join PodMatch (the "AirBNB" of Podcasting): https://www.joinpodmatch.com/drchrisloomdphd We couldn't do it without the support of our listeners. To help support the show: CashApp- https://cash.app/$drchrisloomdphd Venmo- https://account.venmo.com/u/Chris-Loo-4 Buy Me a Coffee- https://www.buymeacoffee.com/chrisJx Thank you to our sponsor, CityVest: https://bit.ly/37AOgkp Click here to schedule a 1-on-1 private coaching call: https://www.drchrisloomdphd.com/book-online Click here to purchase my books on Amazon: https://amzn.to/2PaQn4p Follow our YouTube channel: https://www.youtube.com/chL1357 Thank you to our advertisers on Spotify. Financial Freedom for Physicians, Copyright 2023

This week, Mary Beard is fascinated by an ancient graffito, and novelist Michael Hughes on the murder case that almost brought down the Irish government.A Don's Life: https://www.the-tls.co.uk/articles/virgil-on-pots-and-walls-blog-post-mary-beard/'A Thread of Violence: A Story of Truth, Invention and Murder', by Mark O'ConnellProduced by Charlotte Pardy Hosted on Acast. See acast.com/privacy for more information.

For a long time I been thinking about this fighter and how much I wanted to revisit it.  Ehergeiz also known as The Final Fantasy 7 fighter for Ps1.  Come join us as we talk about this 3D Fighter that was ahead of its time. Starring Mike Albertin, Michael Hughes, and Adam Merica. Adam's Podcast - https://podcasters.spotify.com/pod/show/tgcb A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_  

We take a look at another Capcom Beat Em up, King Of  Dragons.  Come listen to us as we talk about our experience playing this Snes/Arcade game. Starring Mike Albertin, and Michael Hughes.  A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_

It's time for another Mega Episode where we continue our Megaman quest.  This is the title that went back to its roots for MegaMan and had the 8 bit Era.   Starring Mike Albertin, Phoebe Stanton, Michael Hughes, and Blair Farrell.  Phoebes Twitch - Phoebe - https://www.twitch.tv/theletsplayprincess Blairs Website - https://comicbookvideogames.com/ A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC Megaman X5 - 221 https://gamesmymomfoundpodcast.podbean.com/e/megaman-x5-221 Mega Man 8 - GMMF 210 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-8-gmmf-210 Top 10  Mega Man Robot Masters 1-7 (Top 10 in Gaming 7) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/top-10-mega-man-robot-masters-1-7-top-10-in-gaming-7-gmmf Mega Man 7 - GMMF 184 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-7-gmmf-184 Mega Man 6 (Mini 17) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-6-mini-gmmf Mega Man X4 - GMMF 166 https://gamesmymomfoundpodcast.podbean.com/e/megaman-x4-gmmf-166 Mega Man Legends 2 - GMMF 162 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-legends-2-gmmf-162 Mega Man X3 - GMMF 136 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x3-gmmf-136 Mega Man 5 (Mini 12) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-5-mini-12-gmmf Mega Man 4 (Mini 11) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-4-mini-gmmf Mega Man Legends - GMMF 117 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-legends-gmmf-117 Mega Man Powered Up! (Mini 6) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-powered-up-mini-gmmf Mega Man X2 - GMMF 99 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x2-gmmf-99 Mega Man Let The Games Begin (Comic 18) - GMMF https://gamesmymomfoundpodcast.podbean.com/emega-man-let-the-games-begin-comic-gmmf Mega Man X - GMMF 85 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x-gmmf-85 Mega Man 1 & 2 - GMMF 25 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-1-2-gmmf-25        

This week we take a look at a Metroidvania that jump started the Genre again.   A game that did its best to mimic Super Metroid.  Come listen to what we thought as we explored the bowels of Shadow Complex.  Starring Mike Albertin, Michael Hughes, Michael Colby, and Kerry Chandler. Kerrys Twitch - https://www.twitch.tv/kerooseta Michael Colbys Podcast - https://podcasts.apple.com/us/podcast/jack-billings-presents-me-and-my-neighbor-michael/id1465673329 A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC

We bring you this months What Are Ya Playing, where we take a look at what we been playing, and watching in the past month.  Come listewn to what we been up to. Starring Mike Albertin, Michael Hughes, Michael Coldy, and Kerry Chandler. Michael Colby's Podcast - https://podcasts.apple.com/us/podcast/jack-billings-presents-me-and-my-neighbor-michael/id1465673329 Kerry's Twitch - https://www.twitch.tv/kerooseta A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC

It's time for another Mini where we cover another Capcom game.  We change our clothes for this game all about Mickey trying to find his dog. Starring Mike Albertin, and Michael Hughes.  A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC

It's time for to once again travel to the X games to cover the 5th entry in this series. Welcome to the Mavericks.  Get ready to stand in the cold November rain. Starring Mike Albertin, Michael Hughes, Blair Farrell, and Robbie Sherman.  A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC Mega Man 8 - GMMF 210 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-8-gmmf-210 Top 10  Mega Man Robot Masters 1-7 (Top 10 in Gaming 7) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/top-10-mega-man-robot-masters-1-7-top-10-in-gaming-7-gmmf Mega Man 7 - GMMF 184 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-7-gmmf-184 Mega Man 6 (Mini 17) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-6-mini-gmmf Mega Man X4 - GMMF 166 https://gamesmymomfoundpodcast.podbean.com/e/megaman-x4-gmmf-166 Mega Man Legends 2 - GMMF 162 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-legends-2-gmmf-162 Mega Man X3 - GMMF 136 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x3-gmmf-136 Mega Man 5 (Mini 12) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-5-mini-12-gmmf Mega Man 4 (Mini 11) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-4-mini-gmmf Mega Man Legends - GMMF 117 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-legends-gmmf-117 Mega Man Powered Up! (Mini 6) - GMMF https://gamesmymomfoundpodcast.podbean.com/e/mega-man-powered-up-mini-gmmf Mega Man X2 - GMMF 99 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x2-gmmf-99 Mega Man Let The Games Begin (Comic 18) - GMMF https://gamesmymomfoundpodcast.podbean.com/emega-man-let-the-games-begin-comic-gmmf Mega Man X - GMMF 85 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-x-gmmf-85 Mega Man 1 & 2 - GMMF 25 https://gamesmymomfoundpodcast.podbean.com/e/mega-man-1-2-gmmf-25  

We get ready to bring you a fiery episode all about revenge.  We go back to where it all started and play God of War for the Ps2.  Come join us as we discuss this action game that set the precedent that is to come. Starring Mike Albertin, Michael Hughes, Nathan McClellan, and Barry Carenza. Premium Edition Games - https://premiumeditiongames.com/ A Gamer Looks at 40 - https://feeds.buzzsprout.com/1426576.rss Helena - @HelHathFury on TikTok Patreon - https://www.patreon.com/GamesMyMomFound Follow us on Facebook. Twitter - @Mom_Found Instagram - gamesmymomfound_ YouTube  - https://youtube.com/c/GamesMyMomFoundPodcast Discord - https://discord.gg/YQRZB2sXJC

Sponosored byCentrapeak: https://centrapeak.com/#ref=63d16332251e5Promo Code: Redefine20TL;DRAre you interested in becoming a personal trainer? Do you want to help others achieve their fitness goals while also pursuing your passion for health and wellness? In this video, we'll be discussing how to become a personal trainer, and we have a special guest speaker, Michael Hughes, the founder of Gymnazo, to share his tips and tricks with us.First, we'll cover the important steps you need to take to become a personal trainer. These include getting certified by a recognized organization like NASM, ACE, or ISSA, gaining experience through internships or entry-level jobs, and developing a specialized skill set in areas like strength training, yoga, or nutrition.Next, we'll dive into what it takes to be a good personal trainer. Michael will share his insights on the key qualities and skills that make for an effective trainer, such as empathy, communication, and a strong work ethic. He'll also provide tips for building a successful career as a personal trainer, including networking, marketing, and developing a niche area of expertise.Throughout the video, we'll use commonly searched keywords like "personal trainer certification," "how to become a personal trainer," and "tips for personal trainers" to ensure that our content is easily discoverable and relevant to our audience.So, whether you're just starting out on your journey to becoming a personal trainer or looking to take your skills to the next level, be sure to tune in to this video to learn from Michael Hughes and get inspired to pursue your passion for fitness and wellness. Don't forget to like, comment, and subscribe to our channel for more great content!ABOUT MICHAEL HUGHESMichael is the Founder, Co-Owner, COO & Movement Practitioner of Gymnazo. Since 7th grade, Mike always knew he had a passion and calling in his life to fix broken bodies and get people back to enjoying their lives. He is Gymnazo's innovator, internal movement guru, and the one who is deeply connected to the dream to blend restoration training with performance.CONNECT WITH MIKEhttps://www.linkedin.com/in/michael-hughes-1b5bb9a/https://www.gymnazo.com/

A transcript of this episode is available here: thedanceedit.com/transcript-episode-144Pacific Northwest Ballet's website: pnb.org"Giselle" tickets and info: pnb.org/season/giselleEdwards' Instagram account: instagram.com/ashtonedwards14Hughes' Instagram account: instagram.com/zsilasmichael Visit/add to the Dance Media Events Calendar: dancemediacalendar.com/Get the latest dance news direct by subscribing to our free newsletters. Find the ones that match your interests: dancemagazine.com/subscribe

Michael Hughes, the founder of CEO of Gymnazo, grew his gym from a 300 sq. ft. to 13,000 sq. ft. facility where they do 1-on-1, semi-private, small group and even online training. He has a background in physical therapy, which he weaves into his programs. Starting in a big box gym, he created his own boutique within the gym, the beginnings of what is now Gymnazo. In this episode, he talks to us about how to keep a client for life, leveraging the model you have to grow your business and why the online coaching business is where he sees massive leverage, how they got a Google 5-star review rating, and more!