Podcast appearances and mentions of bill mcguire

Melanie and Bill McGuire closed on their first home on April 28th, 2004. Two days later, Melanie filed a restraining order against her husband, claiming Bill hit her before leaving the house. Bill was missing for several days until his dismembered remains were found in three suitcases in the Chesapeake Bay. Melanie soon became the main suspect.Join Mike and Gibby as they discuss Melanie McGuire. The spouse is one of the first people that police have to rule out in a homicide case. They were unable to rule Melanie out. The more details the police learned, the more Melanie's story changed. And very little of what she had to say made sense.You can help support the show at patreon.com/truecrimeallthetimeVisit the show's website at truecrimeallthetime.com for contact, merchandise, and donation informationAn Emash Digital productionSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today's episode we talk with activist Sinan from the organization Climaximo about organizing during and against accelerating climate change. We start the conversation by describing some of the principle that our political work is based upon, in particular that the real risk of climate collapse is underrepresented and that the capitalist class will always resist any meaningful structural change. Then we talk about Climaximo, their mode of organizing and plans for the future. Sinan explains to us how they operate under the assumption of a state of climate emergency and their effort to frame climate change as a war waged by the capitalist class against the rest of the world. We finish with some book recommendations and a call to get organized. ===== Re(Sources): Climaximo web: https://www.climaximo.pt/ fb: /climaximopt ig: @climaximopt Naomi Klein, This Changes Everything: Capitalism vs. The Climate, Simon & Schuster (2014) https://www.goodreads.com/book/show/21913812-this-changes-everything Rob Nixon, Slow Violence and The Environmentalism of The Poor, Harvard University Press (2010). https://www.goodreads.com/book/show/10429440-slow-violence-and-the-environmentalism-of-the-poor Bill McGuire, Hothouse Earth: An Inhabitant's Guide, Icon Books (2022). https://www.goodreads.com/book/show/61336424-hothouse-earth Andreas Malm and the Zetkin Collective, White Skin, Black Fuel: On The Danger of Fossil Fascism, Verso (2021). https://www.goodreads.com/book/show/56708410-white-skin-black-fuel Artwork by Alis Balogh Music: Capitalism is Toxic song: https://youtu.be/cMPt6AA6NOY

In Episode 5, State of New Jersey v. Melanie McGuire, Lisa and Kyle talked about the case against Melanie McGuire. Between May 5 and May 16, 2004, three suitcases containing dismembered human remains washed up near the Chesapeake Bay Bridge-Tunnel in Virginia. The remains inside the cases were identified as Bill McGuire, a New Jersey computer program analyst. In 2007, his wife, Melanie, was convicted of first degree murder, possession of a weapon for an unlawful purpose, desecration of human remains and perjury. In July, 2007, she was sentenced to life in prison, plus five years, making her ineligible for parole until 2073. We'll talk about Bill's disappearance, the McGuires' troubled marriage and the evidence against McGuire, along with the course of her direct appeal and post-conviction claims since her 2007 conviction.

Episode 9- On this week of Not For The Faint, Summer dives into the mysterious disappearance of 5-year old Summer Wells. After that, Alyssa covers the chilling details of the Suitcase Murder, a case involving Melanie and Bill McGuire.

Trois mois après son élection, le président argentin « s'en sort très bien », estime La Nacion à Buenos Aires. Pour le quotidien proche du pouvoir, « malgré les mesures d'austérité, Milei conserve le niveau d'acceptation et de consensus qu'il avait obtenu dans les urnes lors du second tour de la présidentielle ». Avec, d'après les derniers sondages, un peu plus de 56% d'opinions positives et un peu plus de 42% d'opinions négatives.« Au cours de ses 100 premiers jours à la tête de l'Argentine, Javier Milei a commencé à démolir l'ancien modèle économique pour en fonder un nouveau, constate pour sa part El Pais à Madrid. Dans la nouvelle Argentine, il n'y a pas de place pour le déficit budgétaire : Milei a sabré dans les retraites, les travaux publics et les prestations sociales. Il n'y a pas non plus de place pour un État régulateur et omniprésent : "Si cela ne tenait qu'à moi, je privatiserais tout", a-t-il répété dans sa dernière interview. Avec son message messianique, en faveur d'une Argentine économiquement libérale et socialement conservatrice, le président divise les 46 millions d'habitants du pays entre "les bons Argentins" qui le soutiennent dans ses décisions et "la caste" (comme il la nomme) qui s'oppose à ses projets, que ce soit par le biais de la politique, de la justice ou de la rue. »Parallèlement, poursuit El Pais, « Milei impose une politique de fermeté à l'égard des criminels et des manifestants, il mène une croisade culturelle contre la gauche et ce qu'il appelle "l'idéologie du genre" et il promeut un changement des alliances internationales qui ferait de l'Argentine un allié inconditionnel des États-Unis et d'Israël ».Un pays déchiréReste que les promesses de Javier Milei semblent « de plus en plus difficiles à tenir ». C'est ce que relève le Corriere Della Serra à Rome.« L'Argentine reste déchirée : entre ceux qui regrettent l'État bureaucratique du bien-être péroniste, qui prenait l'eau de toutes parts depuis quelque temps, et ceux qui espèrent, avec la tronçonneuse anti-système de Milei, revenir à la glorieuse époque du début des années 1900, lorsque Buenos Aires était l'une des villes les plus riches du monde. Entre les deux, il y a la réalité d'aujourd'hui, constate encore le quotidien italien. L'indice de pauvreté dépasse largement les 40% enregistrés l'an dernier, la consommation est en chute libre et les manifestations pourraient paralyser le pays. Surtout, le refus des dépenses publiques entraîne le risque d'un appauvrissement accru de la classe moyenne qui a été jusqu'à présent l'épine dorsale de l'Argentine. »Plus de 40 degrés l'été en Angleterre en 2050 ?À la Une également, le réchauffement climatique. Nous sommes « au bord du gouffre », a déclaré ce mardi 19 mars le secrétaire général des Nations unies, Antonio Guterres, après un dernier rapport alarmant.Et le Guardian à Londres se projette dans un futur proche, un futur bien sombre, avec cette tribune du climatologue Bill McGuire. « Août 2050 : le Royaume-Uni est en proie à la pire vague de chaleur jamais enregistrée, écrit-il. Les températures dans une grande partie de l'Angleterre ont dépassé les 40 degrés pendant huit jours consécutifs. Les maisons mal isolées du pays se transforment en fournaises, et des milliers de personnes doivent camper la nuit dans les rues et les parcs dans une tentative désespérée de trouver le sommeil. Les urgences des hôpitaux sont inondés de patients, pour la plupart des personnes âgées et vulnérables en proie à la déshydratation et aux coups de chaleur. Le bilan des morts est déjà estimé à plus de 80 000. »Une vision apocalyptique mais tout à fait plausible. Et les politiques ne font rien, déplore Bill McGuire, toujours dans les colonnes du Guardian : « Ni les conservateurs ni les travaillistes ne semblent gênés par le chaos climatique qui nous attend, mais pour sauver des vies, ils doivent agir. »

Show: Forensic Files 2Episode: Human SawdustAn unclaimed suitcase can possibly hold glorious treasures or rotting buttholes. A suitcase found floating int he ocean can never be a good thing, but a family opened it up and found human legs. More suitcases popped up holding even more body parts. Police find out that it was a man names Bill McGuire , he also had a wife Melanie. Melanie might have some mental health issues.....Support the showCheck out our website: https://www.buzzsprout.com/837988 Linktree: https://linktr.ee/itsalwaysthehusbandpodcast Like our Facebook page and join our group!! Instagram: @itsalwaysthehusbandpodcast Twitter: @alwaysthehubs Etsy Shop: https://www.etsy.com/shop/ItsAlwaysTheHusband?ref=simple-shop-header-name&listing_id=776055218 Theme song by Jamie "I'm Gonna Kill You, Bitch" Nelson

  The Dead Pair Blast at Vero Beach Clay Shooting Sports was held December 1st and 2nd 2023.  This was the inaugural event hosted by the Dead Pair Podcast and the club staff. After the success of the shoot, it was determined to make this an annual event and EXPAND it into a big blast shoot!.       But how did we determine it was a success?  We asked people that have been in this game for a long time, that were not only in attendance but also competed in the event.          Enter Mike Luongo, Bill McGuire, and Malcom Parker! Mike is not only a competitor, but also a course manager, target setter, and event manager at his home club. As for prelim winner Bill McGuire and main event winner Malcom Parker, do we really need to give their resume? These are 2 professional veterans of the sport that have shot events all over the country, and they know what makes a good tournament!    We have all 3 of these gentleman on to discuss everything about the event, and why you need to attend The Dead Pair Blast 2024!  -Mike Luongo- (302)632-7573DEAD PAIR GOLF CART RAFFLE - YouTube link to video - https://www.youtube.com/watch?v=WJTkFcTPzHo.  Raffle link - https://e.givesmart.com/events/z3U/- Elite Shotguns - https://elite-shotguns.com- Fiocchi USA - https://fiocchiusa.com- Rhino Chokes - https://rhinochokes.com- OtoPro Hearing Service - https://otoprotechnologies.com- RE Ranger - https://www.reranger.com (10% Discount = DEADPAIR)- Atlas Traps - https://www.atlastraps.com- Dawn Grant -https://dawngrant.com. Dead Pair Promo-  https://dawngrant.com/pages/dead-pair-promo- Vero Beach Clay Shooting - https://verobeachclayshooting.com- Scorechaser - https://scorechaser.com/-  Chad Roberts - email- bpsipro@gmail.com The Dead Pair Podcast - https://thedeadpair.com FACEBOOK- https://www.facebook.com/Thedeadpair. INSTAGRAM- https://www.instagram.com/thedeadpairpodcast/YOUTUBE- https://youtube.com/channel/UCO1ePh4I-2D0EABDbKxEgoQ

Welcome back to this week's episode of SERIALously! In today's episode, we're discussing a case that may make you feel like you know exactly what will happen next and, at other times, feel like you are being gaslit. The story takes place in the Spring of 2004 in a quiet suburban town in New Jersey. Melanie and Bill McGuire were going about their everyday lives when the lines of normalcy were suddenly blurred, and the unexpected happened. We talk about a lot of unbelievable cases, and this story is no exception. In fact, one of the most incredible parts to me is that so many people have strong, differing opinions on what exactly happened. Some are thoroughly convinced, some are not, even almost 20 years later. On the other hand, some believe that what went down between Melanie and Bill will forever remain a mystery. So what exactly happened here? And why do some people believe that the person responsible for what occurred could still be on the loose?  Your True Crime BFF, Annie Elise  Today's Sponsors: Nuts.com - Get a free gift with purchase and free shipping on orders of $29 or more when you go to https://www.Nuts.com/ae Better Help - Visit https://www.BetterHelp.com/ae today to get 10% off your first month. PDS Debt- Get your free debt analysis just for completing the quick and easy debt assessment at www.PDSDebt.com/Save.  Zoc Doc- Go to https://www.Zocdoc.com/ANNIEELISE and download the Zocdoc app for FREE. Then find and book a top-rated doctor today. All Social Media Links: https://www.flowcode.com/page/annieelise_ About Me: https://annieelise.com/ SERIALously FB Page: https://www.facebook.com/SERIALouslyAnnieElise/ For Business Inquiries: 10toLife@WMEAgency.com Credits: Court TV Trial Vault ABC 20/20

After a fight with his wife, Melanie, Bill McGuire went missing.  Friends and family were concerned, but Melanie never reported her husband missing.  After about two weeks of not seeing or hearing from Bill, Melanie was informed that her husband was deceased and his body had been found in three separate suitcases in the Chesapeake Bay.  After months of investigation, Melanie was found guilty of her husband's murder solely on circumstantial evidence, but to this dayl maintains her innocence.  Many people believe she was wrongfully convicted.  The question would then remain, who killed Bill McGuire? Trigger Warnings: Murder by Gunshot, Dismemberment, Domestic Abuse, Gambling Addiction Hang with us: Follow Us on Instagram Like Us on Facebook Join our Case Discussion Group on Facebook Get Killer Queens Merch Bonus Episodes Support Our AMAZING Sponsors: Lume: As a special offer for listeners, new customers GET $5 OFF a Lume Starter Pack with code Queens at LumeDeodorant.com. Canva: Collaborate with Canva for Teams! Right now, you can get a FREE 45-day extended trial when you go to Canva.me/QUEENS. Hatch: Right now, Hatch is offering our listeners up to 15% off your purchase of a Hatch Rest and free shipping at hatch.co/queens. Athena Club: Show your skin you care with the Athena Club Razor Kit! Get started with Athena Club today by shopping in-store at Target nationwide - just head to the shaving aisle to buy your razor and refills! © 2023 Killer Queens Podcast. All Rights Reserved Audio Production by Wayfare Recording Music provided by Steven Tobi Logo designed by Sloane Williams of The Sophisticated Crayon YouTube Editing by Jennifer Da Silva

You are living on a planet that is 1.1°C hotter than 100 years ago. By 2100, your future family members could be living in a 3°C world. This means mass deaths from extreme heat. Failing agriculture and food scarcity. Lack of drinkable water. Mass climate migration. Cities underwater. Civil unrest, and other dangers that you may not have even thought about. It's not IF these things will happen, it's how soon and how bad it will get. Buckle up.In this episode, we look at the path we are currently on and attempt to illustrate what daily life could be like as the earth warms to 3°C. We explore where we might adapt and where adaptation could be impossible. With our four guests, we look at just how dependent we are on natural systems and talk about what will happen as these systems break down. We explore the changes that are already happening in food production and what we will have to do as temperatures rise and weather patterns shift, and speak to how the climate crisis is going to change myriad other aspects of our lives on Earth. Our guests are some of the top scientists and economists who have studied these issues for decades, written sections of IPCC reports, and books, and compiled meta-studies of existing literature. Each one echoes the same message - Life at 3°C is very, very bad: but that doesn't mean it's inevitable. While there is still time to prevent further danger, the window is closing.In this episode, our guests include: Dr. Bill McGuire, Emeritus Professor of Geophysical & Climate Hazards at University College London, author of several books including Hothouse Earth.Dr. Camielle Paramsean, Professor at CNRS (SETE - Experimental and Theoretical Ecology)Dr. Edmond Totin, Research Scientist at ICRISATDr. Peter Howard, Economic Fellow at Institute for Policy IntegrityResources: Hothouse Earth (Bill McGuire)Ministry for the Future (Kim Stanley Robinson)The Sixth Extinction (Elizabeth Kolbert)Special Report: Global Warming of 1.5C (IPCC)Extreme Heat Will Change Us (New York Times)UN Emissions Gap Report 2022 covers how policies currently in place point to a 2.8°C temperature rise by the end of the century.Wet Bulb Globe Temperature (National Weather Service)IPCC 6th Assessment Climate Change 2022: Impacts, Adaptation and Vulnerability - Authors Camille Parmesan (Chapter 2: Terrestrial and freshwater ecosystems and their services), Edmond Totin (Chapter 9:...

Le 5 Mai 2004, Bill McGuire ne rentre pas chez lui et surprise, sa femme, Mélanie ne s'inquiète pas ! Pourtant, les enquêteurs vont découvrir une étrange histoire... Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Three separate suitcases were found in the Chesapeake Bay area, all containing dismembered body parts. Authorities were able to identify the body as Bill McGuire. Tracking down his killer uncovered a shocking series of infidelity, addiction, and a secret pregnancy. Try Nom.com/KILLER Go to VEGAMOUR.com/killer and use code killer to save twenty percent on your first order!  If you have any thoughts on this case or any other case, or just want to get in touch with Savannah about the show, email her at killerinstinctpodcast@gmail.com. Watch the podcast on YouTube: https://bit.ly/KillerInstinctYT Don't forget to subscribe to the podcast for free wherever you're listening or by using this link: http://bit.ly/KillerInstinctPod If you like the show, telling a friend about it would be helpful! You can text, email, Tweet, or send this link to a friend: http://bit.ly/KillerInstinctPod Follow Savannah on IG: @savannahbrymer Follow Savannah on Twitter: @savannahbrymer Learn more about your ad choices. Visit podcastchoices.com/adchoices

In May of 2004, 3 suitcases containing the dismembered remains of Bill McGuire were pulled from the Chesapeake Bay. His wife, Melanie, claimed she hadn't seen Bill in the days leading up to his murder, but a jury didn't buy it and convicted her of for first-degree murder. Did Melanie McGuire kill her husband, or was it Bill's gambling debts that cost him his life? Tune in to hear Karla's and Michael's take on this twisted case!

Professor Bill McGuire wrote the book, "Hothouse Earth: An inhabitant's guide" and through his wise and gentle counsel, he helps readers better understand the complex and disagreeable issue of global heating. People can learn much more about Bill from his website or from The Word Forest Organisation where he has been appointed as the group's Special Scientific Advisor. Bill is the Professor of Volcanology, volcanic risk, volcanic hazards, volcano instability, climate change, geophysical hazards, and natural disasters at the University College of London. --- Send in a voice message: https://podcasters.spotify.com/pod/show/robert-mclean/message

Professor Bill McGuire (pictured) wrote "Hothouse Earth" and was kind enough to have a chat with Climate Conversations. "Greens showdown with gas sector threatens Labor's climate reforms". "UAE to launch Cop28 presidency with oil boss tipped for leading role"; "The past eight years were the hottest on record, despite La Nina"; "Cannon-Brookes takes swipe at Forrest, commits to rebuilding Sun Cable"; "Giant solar farm project in doubt after disagreement between Mike Cannon-Brookes and Andrew Forrest"; "Project Drawdown: A Cautious Case for Climate Optimism"; "U.S. Carbon Emissions Grew in 2022"; "Four ways winter heatwaves affect humans and nature"; "World's large dams could lose quarter of capacity by 2050, says UN"; "Climate change and extreme weather events have doctors worried". --- Send in a voice message: https://podcasters.spotify.com/pod/show/robert-mclean/message

“I want to spend my time solving problems,” says Iggy Bassi, founder and CEO of Cervest, a platform that uses climate data, science expertise and data modeling to help companies predict their climate risk. It measures the potential damage a company's assets, like buildings, factories and property, could suffer from their surrounding weather conditions, and the  potential resulting financial loss. With this data, it helps companies not mitigate risk, but adapt assets over time. Though it's not just real estate firms or manufacturers that have to worry about extreme incidents like flooding or storms. As Iggy points out, all businesses across all industries are at risk from the everyday effects of climate change.   Iggy considers this his driving mission—to democratize this data and get it into the hands of decision makers in order to serve the greater good. He talks about the process and necessity of marrying the mission to the method, that to achieve its noble ends, a company must still follow a capitalistic business model and make itself competitive in the market. Both are equally necessary and as Brendan points out, making money and doing good works are not mutually exclusive.  It's a matter of deciding what you want to invest your time in. It also means choosing the right people to be part of your mission. Iggy emphasizes the amount of time he spent and continues to spend considering his investors and encourages listeners to do the same.  Quotes: “Most of our losses actually came because of these extreme events, we just couldn't predict them. We couldn't control them. So I think in 2014 I sort of picked up a climate model. It helps to think about climate modeling. I said, `I want to know what's going to happen to my facility,  for my $6 million factory and tell me what's going to happen to this.” (8:14-8:38 | Iggy) “I think there's a more fundamental question about, ‘Where do you want to spend your energy as well. I want to spend, personally, my energy on solving problems. So that's what really drives me is ‘Can we make an impact because we're all going to work hard, whether you're in for profit, or social sector, what is the purpose to the work?” (12:10-12:31 | Iggy)  “We are a B Corp that allows us to marry the mission with raising capital, creating a certain type of culture, which was all driven by a central mission. Can we take the power of plant intelligence into the hands of decision makers? Can we democratize this complex data? So people like me are not stuck on the farms going forward? People can get answers when they need them, how do I protect my assets? How do I adapt my assets? So we want this intelligence to be democratized as fast as possible at the lowest possible price point, potentially, with a freemium model as well, so that people can get a certain level of climate intelligence on their most critical assets for free. And then the larger banks, insurance companies and governments will actually pay for this.” (12:51-13:31 | Iggy) “Even at the height of COVID, most global surveys, when they asked citizens the number one concern, it wasn't COVID, it was still climate. And climate is a number one concern across the world, when you ask the citizens, particularly the younger generations.” (25:21-25:37 | Iggy) “I'm always always careful about who my capital partners are. I spent a long time focusing on choosing the right investment partners, because if you don't have that alignment, it can be catastrophic later on.” (33:53-34:05 | Iggy)  “I think there is a combination of mission driven people who are technically good, and people who've got method. So you have to marry mission with method. Because at the end of the day, it is a competitive business, it's a competitive market, you have to be able to sell this stuff into the marketplace, build a brilliant product. And you have to be a commercially orientated organization over time. So mission is great, method is also great. But you need a combination of the two, particularly if you're solving this type of problems.”(36:40-37:10 | Iggy) Connect with Brendan Dell: LinkedIn: https://www.linkedin.com/in/brendandell/ YouTube: https://www.youtube.com/c/BrendanDell Instagram: @thebrendandellTikTok: @brendandell39 Buy a copy of Brendan's Book, The 12 Immutable Laws of High-Impact Messaging: https://www.indiebound.org/book/9780578210926  Connect with Iggy Bassi:Twitter:@IggyBassihttps://cervest.earth/Check out Iggy's recommended books:   Hothouse Earth: An Inhabitant's Guide by Bill McGuire https://www.indiebound.org/book/9781785789205   Nutmeg's Curse by Amitabh Ghosh and Sam Dastor https://www.indiebound.org/book/9798212010450   Origins: How Earth's History Shaped Human History by Lewis Dartnell https://www.indiebound.org/book/9781541617902 Please don't forget to rate, comment, and subscribe to Billion Dollar Tech on Apple, Spotify, or wherever you listen to podcasts! Use code Brendan30 for 30% off your annual membership with RiverSide.fm  Podcast production and show notes provided by HiveCast.fm

Professor Bill McGuire rattled a few cages when he published "Hothouse Earth" and has now written an opinion piece in The Guardian: "The big takeaway from Cop27? These climate conferences just aren't working". "Analysis: Australia's climate policies don't match its big talk at COP27". "It's time to add climate change and net-zero emissions to the RBA's top 3 economic goals". "Long-duration storage firm Energy Vault pivots to short-term batteries". "What planting tomatoes shows us about climate change". "How electric vehicles will change cities". "Chefs, doctors and real estate developers among new coalition calling to rid kitchens of gas cooking". "‘We couldn't fail them': how Pakistan's floods spurred fight at Cop for loss and damage fund". "University College, London". --- Send in a voice message: https://anchor.fm/robert-mclean/message

In this episode of Instant Genius, McGuire explains why it is now practically impossible for us to keep climate change on the right side of the 1.5-degree target set by the Paris Agreement, what the Earth could look like in 2100 and what we can still do to mitigate the worst impacts. Hosted on Acast. See acast.com/privacy for more information.

Bill McGuire is a Professor Emeritus of Geophysical and Climate Hazards at University College London, and a writer, who is regularly published in The Guardian, The Times, and The Observer. He is the author of many books, notably the newest, Hothouse Earth - an inhabitants guide, which is a look towards the future of our planet.      In this podcast we discuss: The impact of rising sea levels on the earth's crust, volcanos, coastal cities, and marine life Humanity's downward spiral due to the climate crisis   Capitalism and climate change And at the end, I chat about how I'm trying not to be sad all the time about what the future is looking likely to hold.    Support for the podcast   I'm an independent podcaster, which is a fancy way of saying no one pays me a regular wage. And, to level with you, that is terrifying- all of the time. So, if you like what I do and want me to keep doing it please support the show in one of the following ways.   - Share the podcast with a friend, or review the podcast.    - Make a one-off donation with BuyMeACoffee   I work with a couple of great companies who have discounts arranged for A Need To Read listeners, they're listed below. The discounts (BH) + freebies (AG) will already be applied when you click the link.    - Go to Therapy and get 10% off your first month with BetterHelp, who sponsor the show   - Get your nutrition covered with the all-in-one AG1 shake from Athletic Greens, who also sponsor the show.    - You can also give me feedback/comments/validation by emailing me: hello (at) aneedtoread.co.uk  

Three suitcases were found floating near the islands of the Chesapeake Bay Bridge-Tunnels between May 5, 2004, and May 16, 2004. After investigators released a composite sketch of the victim, he was identified as Bill McGuire, a Navy veteran and computer programmer who had two young sons with his wife, Melanie, who would quickly become the prime suspect. Every piece of evidence found during the investigation seemed to implicate Melanie in the murder and dismemberment of her husband but investigators couldn't find much of a motive and didn't have anything that went beyond circumstantial. Melanie had an answer for investigators every time they brought new evidence to light but would her answers be enough to keep her from being found guilty? --- Send in a voice message: https://anchor.fm/middleagedandmediocre/message Support this podcast: https://anchor.fm/middleagedandmediocre/support

In this ClimateGenn episode, I speak with climate scientist & author Professor Bill McGuire about his recent book titled Hot House Earth. Bill discusses the necessity to discuss worse-case climate outcomes at a time when emissions are still rising and political leaders are looking the other way. [Visit https://genn.cc for more content & https://patreon.com/genncc ] We discuss the absence of global leadership in the fight to hold temperature rise to within the boundaries that humanity has thrived for the last 11 thousand years. The rate of change means that the next 100 years, let alone the next ten thousand, really require global leadership and collective action from everyone on Earth who has the ability and agency to act. In the next episode, I speak with former XR spokesman, author, and philosopher, Professor Rupert Read, and Systems and culture change strategist, Paddy Loughman, who have been working towards establishing a new inclusive cross-societal paradigm of action to tackle climate breakdown, that they call the Moderate Flank. Thanks for listening to ClimateGenn, you can subscribe on all major podcast channels and Youtube to stay up to date and you can also support this channel via Patreon.

What Matters Most podcast host Paul Samuel Dolman speaks with climate scientist Bill McGuire about the new book Hothouse Earth. The post Bill McGuire #1058 appeared first on Paul Samuel Dolman.

Þann 5. maí árið 2004 fannst fyrsta ferðataskan af þremur sem innihélt sundurskornar líkamsleifar. Rannsóknarlögreglumenn áttu tvö erfið verkefni framundan, að bera kennsl á líkamspartana og að finna út hver bar ábyrgð á morðinu. Það átti eftir að reynast þeim erfitt en þegar litið var á heimilislíf fórnarlambsins þá fór ákveðin atburðarrás að koma í ljós. Í kjölfarið hefur morðinginn fengið nafnið "The Suitcase Killer".    www.pardus.is/mordskurinn www.facebook.com/mordskurinn www.instagram.com/mordskurinn 

Hosted by Andrew Keen, Keen On features conversations with some of the world's leading thinkers and writers about the economic, political, and technological issues being discussed in the news, right now. In this episode, Andrew is joined by Bill McGuire, author of Hothouse Earth: An Inhabitant's Guide. Bill McGuire is Professor Emeritus of Geophysical and Climate Hazards at University College London, a co-director of the New Weather Institute, and was a contributor to the 2012 IPCC report on climate change and extreme events. His books include A Guide to the End of the World: Everything you Never Wanted to Know and Waking the Giant: How a Changing Climate Triggers Earthquakes, Tsunamis and Volcanoes. He writes for many publications including The Guardian, The Times, The Observer, New Scientist, Focus and Prospect, and blogs for the New Weather Institute, Scientists for Global Responsibility, Extinction Rebellion and Operation Noah. Learn more about your ad choices. Visit megaphone.fm/adchoices

Bill McGuire (pictured) is a Professor of Geophysical & Climate Hazards at the University College of London and has written many books, the latest being "Hothouse Earth: an inhabitant's guide", and he has agreed to chat with Climate Conversations just as soon as he has navigated fallout from the book. Writing in the Melbourne Age, Ben Cubby tells us about "Nation in clean car traffic jam after decade of delay". And the World Resources Institute writes about "5 Reasons Cities Should Include Trees in Climate Action". The City of Greater Shepparton is already advanced in this area with its 'One Tree Per Child" program. Other climate links are: "Why is the UK so unprepared for extreme heat and what can be done?"; "Revealed: Car industry's secret emissions plan would slow electric vehicle uptake"; "‘Unacceptable costs': savanna burning under Australia's carbon credit scheme is harming human health; "'Celebrating Agriculture for Development – Outcomes, Impacts and the Way Ahead,”; "Climate Finance Needs Rethinking to Reach Indigenous Peoples on the Ground". Enjoy "Music for a Warming World". --- Send in a voice message: https://anchor.fm/robert-mclean/message

Dr. Bill Mcguire joins the program to talk MLS and Minnesota United ahead of this weeks MLS All-Star Game at Allianz Field in St. Paul.

Hothouse Earth (pictured) by Bill McGuire warns us of both challenging and difficult times ahead. Read the story "‘Soon it will be unrecognisable': total climate meltdown cannot be stopped, says expert" from The Guardian by Robin McKie. Other climate links for today are: "What can I do about climate change? 14 ways to take positive action"; "Study Sees Potential Ways to Mitigate India's Risk of Groundwater Depletion"; "Energy Efficiency in Transportation"; "Humanity can't equivocate any longer. This is a climate emergency"; "Record rain in St. Louis is what climate change looks like"; "Climate change, rising insurance costs, food security singled out in CSIRO megatrends report"; "Action on climate change is action on the cost of living"; "Weather Updates: Deadly Floods Swamp Kentucky, With More Storms to Come"; "Global climate crisis hits home in the U.S. amid record heat and pervasive wildfires"; "Climate breakdown made UK heatwave 10 times more likely, study finds"; "The Tiny Australian Territory That Avoided the Global Energy Crisis"; "Climate Bill ‘Transformative' for Auto and Energy Industries"; "Climate change is intensifying the water cycle, bringing more powerful storms and flooding – here's what the science shows"; "Drought increases rural suicide, and climate change will make drought worse". Enjoy "Music for a Warming World". --- Send in a voice message: https://anchor.fm/robert-mclean/message

Mike Max talks with Minnesota United FC Owner Bill McGuire about the team, Reynoso, the special environment in Allianz Stadium, hosting the MLS All-Star game and more.

TRIGGERWARNUNG: Toxische Beziehungen, häusliche Gewalt Im Mai 2004 tauchten in der Chesapeake Bay drei Koffer auf, die Leichenteile eines Mannes enthielten. Wie sich herausstellte gehörten sie zu einem gewissen Bill McGuire, der allerdings 500 Kilometer vom Fundort entfernt wohnte. Wie kam er dorthin? Wer hatte ihn kaltblütig ermordet und in der Bucht versenkt? Bill lebte mit seiner Frau Melanie und ihren zwei Kindern in New Jersey. Nach außen hin wirkten sie wie die perfekte Familie, die kurz davor stand ihr Traumhaus zu kaufen. Doch wie so oft trügt der Schein und hinter der Fassade sah es ganz anders aus… Ein treffendes Zitat für diesen Fall: „Entweder ist Melanie McGuire schuldig oder sie hat unglaubliches Pech.“ Denn eine lange Liste von Indizien deutete auf Melanie als Täterin hin. Sie wurde angeklagt und schließlich verurteilt. Doch konnte diese Tat zweifelsfrei bewiesen werden? Oder sitzt wohlmöglich eine unschuldige Person seit 15 Jahren im Gefängnis? Euch gefällt unser Podcast und ihr wollt uns unterstützen? Dann gebt uns gerne einen Kaffee aus: ko-fi.com/tellmemordpodcast Folgt uns gerne auch auf Instagram (@tellmemordpodcast) für mehr Content zu den Fällen! +++ Alle Infos zu unseren Werbepartnern & Rabattcodes unter: https://linktr.ee/tellmemordpodcast

Minnesota United FC owner Bill McGuire joins Mike and Pete and talks about starting a professional sports team from scratch.

Three suitcases filled with body parts were discovered washed ashore on Virginia Beach. The remains were identified by friends as 39 year old, Bill McGuire. As police interview Bill's friends they learn that he'd been missing for over 30 days, but his wife Melanie never reported it. Melanie tells investigators that Bill took off after an explosive argument and the two were going through a divorce. Despite this plausible story, Melanie becomes the center of the investigation which uncovers a laundry list of incriminating actions carried out by Melanie leading up to Bill's disappearance. But was she really the perpetrator? Some view the evidence as coincidence. You decide.

As part of our Trees Are The Key Awareness Week 2022, our Managing Director Simon West interviewed Professor Bill McGuire on the future of climate activism. What options do we have? Where are we headed? What needs to happen now? Visit wordforest.org/week to find loads more of our Trees Are The Key Awareness Week content! You'll find specially curated articles, education packs and so much more.

  When it comes to competitors and coaching in sporting clays, there is no one nicer than Bill McGuire! Bill is not only a 2X National Champion, but he has won numerous regionals, zone shoots, big blast shoots, and other large events, that have cemented him as one of the greats in this sport....and all with that big welcoming smile!  We caught up with Bill while he was down in Florida coaching and got his opinion on a variety of topics in our sport. Don't let the "nice older gentleman persona" fool you though. Bill is still a very fierce competitor, and still remains at the top of the results page in just about every shoot he goes to! It's always a pleasure to speak with Bill, and we are sure you will agree with us when you listen to this podcast.  We also feature a RE Ranger segment with Hannah Harens, who gives us her  testimonial on RE Ranger glasses, and how they have helped her shooting!-Bill McGuire coaching- (423) 464-9073-OtoPro - https://otoprotechnologies.com-Rhino Chokes - https://rhinochokes.com-RE Ranger-https://www.reranger.com-BAREPELT-https://barepelt.com-GAMEBORE US-https://www.gameboreus.com-ATLAS TRAPS-https://www.atlastraps.com-NEGRINI CASES-https://negrinicases.com/the-dead-pair/- White Flyer Targets - https://whiteflyer.com-Chad Roberts-email-bpsipro@gmail.com

Bill McGuire joins Mike Max to discuss the upcoming Minnesota United season, and what is sure to be a frigid world cup qualifier as the United States take on Honduras in sub zero weather later in the wekk.

Bill McGuire is an academic, activist, broadcaster, blogger and writer of popular science and speculative fiction. Emeritus Professor of Earth Sciences at University College London, Bill cut his teeth researching the link between volcanism and sea-level change and pioneered research on the geological impact of a rapidly changing climate. Over the past two decades, his expertise on natural hazard has been frequently sought out by government and media broadcasters. In more recent years, Bill has devoted much of his time to climate activism, displaying a flair for the cut and thrust of social media, as well as taking aim at the delusions of orthodox climate policy, including the dangers of geoengineering (in his most recent fiction book, Sky Seed). Brace yourselves for a no holds barred account of the climate science, as Bill spells out why dangerous pervasive climate breakdown is now all but inevitable. This is not a counsel of despair though, but rather a call for a serious, sober reckoning with our predicament and what we can still do to mitigate the worst impacts. On the way, we also explore the widening chasm between the climate science and political action, the serious, fun and even therapeutic pleasures of writing speculative fiction, the strange absence of public education on the climate emergency, as well as the importance of speaking up in the face of climate denialism, including among friends and colleagues. Bill tweets @ProfBillMcGuire You can learn more about Bill's work here on his website: http://billmcguire.co.uk/ And read Bill's essays on his Cool Earth column on Substack: https://substack.com/profile/23258461-bill-mcguire Articles we discussed include: ‘An open letter to all climate scientists', 19 July 2021: https://billmcguire.substack.com/p/an-open-letter-to-all-climate-scientists

Happy New Year! A new notch on humanity's belt never felt so good! As we slowly approach a (touch wood) post-covid era, another crisis looms not far behind. You already know what it is, we don't have to spell it out for you. What you may not know however is that this crisis has an effect on the earth itself. Not the planet, the ground, dummy!  To get some real information on the subject, your hosts grab a couple of torches, a dusty Indiana Jones hat and some protein bars to find Professor Bill McGuire from UCL! As we walk together through caves and hop from one tectonic plate to another, our discussion ranges from the effect of global warming on volcanoes to his eco-thriller novel Skyseed about geoengineering gone wrong. As Bill leads us out of the dark tunnels of the Earth and back onto the surface, we feel like we've got a brand new perspective on the ground beneath our feet. It, also, is part of a fragile ecosystem which can have tremendous ripple effects if disturbed.  You can find Bill on Twitter and more of his work on his website  Let us know your thoughts at risingwiththetide@gmail.com as well as what you'd like us to talk about next!  Links to all streaming platforms and socials: linktr.ee/risingwiththetide  Or head to our website! www.risingwiththetide.org  Songs for the Episode is "It's The End of the World As We Know It" by R.E.M.

On Saturday, our special scientific advisor Bill Mcguire hosted a panel where he gave his thoughts on the current state of climate action. Check out our COP26 news feed for daily, jargon free updates from the conference and the fringe. https://www.wordforest.org/cop26/

Mike Max talks with Minnesota United FC Principle Owner Bill McGuire on the MLS All-Star game coming to Allianz Field, the impression it makes on guests, how does he pitch Minnesota to prospective players and more. See omnystudio.com/listener for privacy information.

5. Mai 2004: Chris und sein Kumpel Don haben heute frei und nehmen ihre Kinder mit auf einen Bootsausflug in die Chesapeake Bay. Als sie ihre Angeln auswerfen, sehen sie ein ungewöhnliches Objekt, das auf dem Wasser treibt: Einen Koffer. In den nächsten Tagen werden an anderen Orten der Flussmündung zwei weitere Koffer gefunden. Ihr Inhalt? Eine Leiche. Eingewickelt in schwarze Müllsäcke. Heute geht es bei uns um einen brutalen Mord, eine unglückliche Beziehung und eine möglicherweise unschuldige Person, die schon seit 14 Jahren hinter Gittern sitzt. Wir sprechen über den Mordfall McGuire. ***Werbung*** Die Links zu unseren Werbepartnern findet ihr unter https://linktr.ee/schwarzeakte Vielen Dank an unsere Partner, die es uns ermöglichen, auch weiterhin spannende Folgen für euch aufzunehmen. ***Link zum Fall*** Foto des Koffers: https://bit.ly/akte68-koffer *** Das Phantombild: https://bit.ly/akte68-phantom *** Fotos des glücklichen Paares: https://bit.ly/akte68-paar *** Foto des Paares mit älterem Sohn: https://bit.ly/akte68-sohn *** Foto des Hauses: https://bit.ly/akte68-haus *** Das empfehlenswerte Buch zum Fall "To Have and to Kill" von John Glatt: https://bit.ly/akte68-buch *** Dokumentation von ABC 20/20: https://bit.ly/akte68-doku *** Der Podcast "Direct Appeal: Melanie McGuire": https://bit.ly/akte68-podcast ***Wir übernehmen keine Haftung für die Inhalte externer Links*** Herzlich Willkommen bei der Schwarzen Akte - dem Mystery True Crime Podcast. Es sind Details, die ein gewöhnliches Verbrechen von einem unglaublichen Mysterium unterscheiden. Wir stellen euch hier Fälle vor, bei denen sich eure Nackenhaare sträuben und von denen ihr bislang steif und fest behauptet hättet, dass so etwas nie im Leben passieren kann. Jeden Dienstag veröffentlichen wir eine neue Folge mit außergewöhnlichen Kriminalfällen und überlegen, ob auch an der merkwürdigsten Spekulation doch ein Fünkchen Wahrheit zu erkennen ist. Schreibt uns gern eure Theorien und weitere spannende Fälle an schwarzeakte@julep.de, auf Instagram an @schwarzeakte, auf Facebook an @SchwarzeAktePodcast oder YouTube an @SchwarzeAkteTrueCrimePodcast ***SPOILER*** In diesem Fall wurde eine Person verurteilt.

Wes sits down with Minnesota United FC's Principal Owner Dr. Bill McGuire to talk about -2021 so far -The challenge of signing players during the pandemic -the search for a new CEO -Development around the stadium -What's holding back MLS?

Fam, today we gotta talk about Melanie McGuire. We're in a bit of a pickle - the story of her being guilty flows. But we've got zilch on the forensic evidence front. So is she guilty or innocent? Your kids are out of school so you decide to take them out on a fishing trip. While fishing you spot a suitcase floating around. Your kid is psyched, thinking they're about to find hidden treasure. But once they open up a suitcase, they find parts of a human body. He was never reported missing and the police will only focus on one suspect : his wife. Is she innocent or guilty? Visuals: https://youtu.be/EzB32uqaHOs 0:00 How did we get here intro 3:50 The case of Bill McGuire 1:32:10 Take outs n outtakes To suggest any future topics, check out the case suggestion form: https://forms.gle/MCy43w7U3KXkHcAw5 The merch : For dat cheap cheap: https://www.teepublic.com/en-gb/user/bamn-podcast For the comfy: https://teespring.com/en-GB/stores/nobodywins Good ol' merch: teespring.com/en-GB/stores/bamn-podcast ; promo code: PODBAMN for 25% off everything! Or on Redbubble: thatbamnpod.redbubble.com Pod links - follow the homegirl: BAMN podcast Apple podcasts: https://podcasts.apple.com/gb/podcast/by-all-means-necessary/id1493266414 Spotify: https://open.spotify.com/show/5UsP1CEksDtxW3HowPLLLU?si=pmNrWm4wTQmdR-B_AZZqCg Pod socials: Patreon: patreon.com/thatbamnpod Twitter: twitter.com/thatbamnpod Instagram: instagram.com/thatbamnpod Email: podbamn@gmail.com If you wanna interact with the homegirl: Twitter: https://twitter.com/majasmeltdown Instagram: instagram.com/majaspassport Email: maja.scepanovic@gmail.com Intro tune by: https://www.fesliyanstudios.com/ Sources: https://www.chillingcrimes.com/blogs/news/melanie-mcguire-1 https://www.youtube.com/watch?v=HdpeJRJIuJc https://heavy.com/entertainment/melanie-mcguire-today-now-2020/ https://murderpedia.org/female.M/m/mcguire-melanie.htmv https://www.chillingcrimes.com/blogs/news/melanie-mcguire-1

Episode 200!!!! This one kind of got away from us. I promise we talk about the match against FC Dallas, we kinda preview the matches against Austin FC and the Portland Timbers. But, again, this one really gets away from us. Special thanks to Bill McGuire, Chris Lidholm, Bruce McGuire, Dan Wade & the original Dave, David Martin for joining us for this very special episode!

When dismembered body parts are discovered in matching suitcases in Chesapeake Bay, authorities rush to identify the unfortunate soul and his killer. Tune in to hear why you should never eat at a Red Lobster in Times Square and why Kenneth Cole Reaction bags don't make the perfect murder cleanup tool. Key Players: Melanie McGuire, Bill McGuire, Bradley MillerFind LOVE MURDER online:Website: lovemurder.loveInstagram: @lovemurderpodTwitter: @lovemurderpod Facebook: LoveMrdrPod

Meghan is the host of the “Direct Appeal” podcast, along with co-host Amy Shlosberg.  Season 1 of Direct Appeal tells the story of Melanie McGuire.  Melanie was convicted for the 2004 murder of her husband, Bill McGuire.  The prosecution presented a compelling case that Melanie drugged, shot and then dismembered her husband.  It seemed to the jury like an open and shut case, but there is certainly more to consider.  Meghan and Amy, as Criminologists, dig into the case to determine if Melanie McGuire is a cold blooded killer, or if she was wrongfully convicted.To suggest a guest or request an interview, please visit our website.  TrueCrimeBinge.comFollow us on social media @TrueCrimeBingeToday's Sponsors:MasterClass.com/Binge - For 15% off an annual membershipBetterhelp.com/Binge - To get 10% off of your first month

Competitive rugby is a young man’s game, and when Nick reached his mid-30s he needed something that could fill the hole rugby left. That’s when he took up clay shooting, a pastime that appealed to him because it combines his love of hunting with the ability to satisfy his competitive drive. Nick shot a couple of beginner level parcours while still living in his native France, scoring in the low single digits out of a possible 25. He wasn’t disheartened by his low scores, but instead took it as a challenge to improve. With his experience as a rugby player, he decided to use a mental coach, a physical coach, and a technical coach — so he knew a little something about training and put that same learning style to use in his shooting game. With hard work, Nick’s shooting improved. Holding Master’s degrees in both architecture and civil engineering, he had built a very successful career running his own companies in France and Vietnam. Clay shooting at the time was a hobby — a fun, competitive sport to pursue in his spare time. Little did he know that a few short years later he would immerse himself fully in both the competitive and business sides of clay target shooting. He’d been shooting for only a year back in 2015 when he visited the U.S. to shoot stateside for the first time. By then he had already gained standing in what’s called Club France, based upon his ranking in the top 24 shooters in that country. Based upon his one year of shooting experience, he was placed in D class at the World FITASC Championship held at Caribou Gun Club. He went on to win D1 in every event he shot at Caribou that week, punching his way into C class. A Move To The US Nick’s wife Cat was born and raised in the U.S. and her whole family lives in southern California. That seemed like a good place to relocate — near family and where their kids could get a good education. The plan was for Nick to run his companies remotely from California and fly back and forth to Asia and France when need be. Upon hearing Nick’s plans, Laporte Chairman, JeanMichel Laporte, told him not to rush into anything once arriving in the U.S. The fact that Nick had built a company in Vietnam and took it from three employees to 80 in a year and a half was not lost on Mr. Laporte. He admired Nick’s business acumen and thought he might be the right person to manage Laporte’s North American division. Because he still owned two successful companies, Nick wasn’t in the market for a job. Although he was already happily employed, he met Mr. Laporte at the NSCA Nationals that October and was made an offer he wouldn’t refuse. “I’m glad I made this choice. Laporte is a very innovative family owned company and if there’s an issue, we always find a way to make it work. The near future looks very bright for us” he said. The French Nick Video Experience Nick liked to record video with his iPhone while on the sporting clays course. He launched a blog at FrenchNick.com and a YouTube channel, quickly building a large online following. “Nobody was doing it and it started getting crazy” he said. Because he is personal friends with a lot of the top shots, he is able to get very close for filming while they’re in the shooting stand. He knows how to move in without bothering them — where to stand, or maybe more importantly where not to stand. He says there aren’t a lot of people who could do that, because they wouldn’t dare come in that close. Some shooting friends have even asked him to come in closer than normal with his iPhone to get footage for instructional videos. Anthony I. Matarese Jr. asked him to record with his phone only four inches from his ear while competing at the Nationals. “You probably couldn’t do that with a regular camera guy” says Nick. “It’s always like an exchange and a balance between what the shooter wants, he doesn’t want and what you need to get good images.” He’s also videoed Zach Kienbaum, Cory Kruse, Gebben Miles, Bill McGuire, Brad Kidd Jr., Bobby Fowler, Mike Wilgus, Derrick Mein and Diane Sorantino during competition and says you can’t make any mistakes — even though the big time shooters are asking to be videoed, they’re still shooting to win. Anthony actually used some of Nick’s iPhone competition footage in his new instructional videos. There’s not a lot of postproduction editing on his videos before upload. Any post-production work takes place very quickly and 30 minutes later it’s viewable online. “It’s very simple. When I’m at the event, people want to see the video the same day. If I post the video immediately, it’s crazy how many views it gets. Viewers are almost learning about the results when they’re watching the video.” Team Laporte Team Laporte A particularly interesting conversation from the World FITASC in Minnesota still sticks in Nick’s memory. Having shot for only around a year, he asked Laporte Chief Technician, Jeff Allard, why Laporte didn’t sponsor more shooters? Allard replied in a fashion that to this day Nick uses when approached for Laporte sponsorships. What can you bring to the Company? “That makes total sense” says Nick. “Charles Bardou and Christophe Auvret of France were Laporte sponsored shooters because they’re world champion caliber shooters, but I wasn’t. Sponsors need people who can help bring sales and improve the company image. What would I be able to bring to the table for a sponsor?” That is where the idea of blogging and videoing the champions started. Once with Laporte, Nick toured the country and was surprised to find the brand wasn’t better known here. He worked to strengthen the image of the company and built a great sponsored shooter team in the U.S. — all incredible shooters, but more importantly he says, the best people. Anthony I. Matarese Jr., Gebben Miles, Cory Kruse, Bill McGuire, Brad Kidd Jr., Mike Wilgus, Diane Sorantino, Bobby Fowler, Katie Fox and Dania Vizzi are Laporte Dream Team shooters. Nick says with the image they’ve built over the last three years and the new products coming out, Laporte expects 2020 to be a record-breaking year. Historically known for the quality, reliability and consistency of their commercial grade machines, they admittedly have lacked a product line for private users and very small grounds who are shopping for price point. They think their new small capacity pro traps, unveiled at the 2020 SHOT Show, will be a game changer. The smallest will hold 135 targets and the next bigger holds 200. “It’s going to be a game changer, because we’re going to keep the same top quality, but with smaller capacity and with a price that matches the competition.” Shooting Career Highlights Nick was in C class when he arrived permanently in the U.S. in July of 2016 but made Master class by the end of September that same year. He began working with Gebben Miles, who coached him from being a one-eyed shooter to shooting with two eyes open. He later became a student of Anthony I. Matarese Jr. and continues that relationship to this day. He says the most memorable experiences while shooting are not necessarily first place wins. He shot his first 100 straight in competition on the first day of the 2017 Oklahoma State shoot, while squadded with David Radulovich, Tom Seay and father Steve, Danny Vines and his grandson Peyton. Derrick Mein also shot a 100 straight on the first day, so he and Nick were tied going into day two. Nick was on the first rotation on the second day and shot a 96. Derrick eventually answered with a score 97 to take HOA, beating Nick by one bird. The scores shook out Mein 197 HOA, Nick 196 runnerup, and Radulovich 195 M1. Nick says he’s immensely proud to have been bracketed by two World FITASC champions. The following week was the last stop on the 2017 PSCA Pro Tour. Nick shot very well in the qualification round, then won all his matches to make it to the final. Along the way he bested “all these top guys who were my idols” in the Challenge Round event, including Cory Kruse, Bill McGuire and Braxton Oliver. He ultimately lost in the final elimination to Tom Seay and placed runner-up. Shooting Plans The last three years Nick has worked hard on his shooting technique and last year started working with Henry Hopking (Brain Training) on his mental game. Having somewhat neglected the physical aspect of his game, he has been working on that of late and feels like he’s coming back strong in that regard. He’s planning on a good 2020 shooting year with this three-pronged training approach. Unlike years past when he shot around 15,000 registered targets per year, Nick will focus more on quality than quantity. He plans to concentrate on the Main Event and FITASC at the Regionals, U.S. Open and Nationals. In addition to Laporte, he’s proud to be sponsored by Krieghoff, Baschieri & Pellagri, Shurley Brothers and Extreme Chokes. Nick shoots a Krieghoff K80 custom receiver — the Cat Gun, 32-inch skeet barrels with thin wall Extreme Chokes and a Shurley Custom stock. His choice of ammunition is B&P F2 Mach 1oz. at 1,300 fps. Nick’s wife and kids are U.S. citizens and at the end of 2020 Nick himself will be eligible to apply for citizenship of his own. His dream is to one day represent the United States in the World FITASC or World English Championship. A dream that very well may come true. Article by Clay Shooting USA

The Principal Owner of Minnesota United FC, Dr. Bill McGuire, sit down with Wes to talk about: -Minnesota United's best year ever -Managing through the pandemic -Wes gives him a chance to gloat at the Loons' doubters -The long pursuit of Emanuel Reynoso -When fans might be in stands this year -Minnesota United's academy system, including the surprise success of some young Minnesotans -The team's response to Black Lives Matter and the Summer Uprisings -Development surrounding the stadium -The future of the team -Watching Sunderland Til I Die

On April 28, 2004, William McGuire disappeared from the apartment he shared with his wife and two sons in Woodbridge, New Jersey.  His wife, Melanie, claimed the couple had a violent argument that ended with 39-year old Bill storming out of the house, vowing never to return.  Melanie claimed Bill’s behavior had become erratic in recent weeks and claims to this day that Bill was an alcoholic with gambiling debts owed to shady characters.  On May 5, 2004, Kenneth Cole suitcase was picked up by fisherman in Chesapeake Bay near Virginia Beach, Virginia.  Inside were a man’s lower legs.  On May 11, 2004, a man’s head and upper torso in a matching suitcase were found on a beach by a bird watcher.   Finally, on May 16, 2004, a man’s lower torso was found in a third suitcase picked up by a boater in the Chesapeake Bay.  Virginia Beach investigators enlisted the media in their effort to identify the victim and a composite sketch led to the body being identified as Bill McGuire, which was confirmed by fingerprint examination.  Join Lisa O’Brien and Michael Carnahan on Tuesday, December 15, 2020, at 8:00 p.m. Central for Clear and Convincing Episode 27, State of New Jersey v. Melanie McGuire.  We’ll talk about the evidence linking McGuire to her husband’s disappearance and murder, including her purchase of a Taurus .38 revolver in Pennsylvania on April 26, 2004, the Kenneth Cole suitcases, a medical service blanket wrapped around Bill’s head when it was found and her admission to “moving” Bill’s car, which continued fragments of human sawdust, in Atlantic City days after Bill “disappeared.”  We are a live show and, as always, calls are welcome at (347) 989-1171.

Vuoden 2004 keväällä Chesapeakenlahdelta löytyi kolme vihreää matkalaukkua, jotka sisälsivät ihmisen ruumiinosia. Ketään ruumiin tuntomerkkejä vastaavaa ei oltu ilmoitettu kadonneeksi, joten poliisit joutuivat pyytämään yleisön apua uhrin tunnistamiseksi. Susan Rice-niminen nainen tunnisti uhrin miehensä parhaaksi ystäväksi, josta pariskunta oli ollut huolissaan jo useamman päivän ajan. Susan ilmoitti tietonsa poliisille ja uhrin henkilöllisyys ja tapahtumien kulku ennen uhrin kuolemaa alkoi hiljalleen selvitä.Ota yhteyttä: jaljillapodcast@gmail.comInstagram: @jaljillapodcastMusiikki: Doug Maxwell - Heartbeat of the HoodRikosuhripäivystys: https://www.riku.fi/palvelut/rikosuhripaivystys-116-006/ puh. 116 006Raiskauskriisikeskus: https://tukinainen.fi/ puh. 0800–97899Apua lähisuhdeväkivaltaan: https://www.nollalinja.fi/ puh. 080005005Suomen Mielenterveysseura: https://mieli.fi/fi Kriisipuhelin: 09 2525 0111LÄHTEET:Kirja: John Glatt: To Have and to Killhttps://www.youtube.com/watch?v=gy5V8subVfM&t=911s&ab_channel=ShanaLaurindahttps://abc.com/shows/2020/episode-guide/2020-09/25-the-secret-in-the-suitcasehttps://www.youtube.com/watch?v=o2w_6O9rPRs&ab_channel=ABCNewshttps://abcnews.go.com/US/suitcase-killer-melanie-mcguire-defends-innocence-inside-prison/story?id=73099717https://nypost.com/2007/04/29/inside-cheating-wifes-gruesome-suitcase-murder/https://www.cbsnews.com/news/the-mcguire-diaries/https://abcnews.go.com/Primetime/story?id=3301941&page=1https://www.nj.com/ledgerarchives/2007/07/mcguire_timeline.htmlhttps://www.nj.com/ledgerarchives/2007/07/mcguire_found_guilty_of_suitca.htmlhttp://murderpedia.org/female.M/images/mcguire-melanie/indictment.pdfhttps://web.archive.org/web/20150701090155/http:/ems.gmnews.com/news/2005-06-07/Front_page/011.htmlhttps://eu.mycentraljersey.com/story/news/2014/04/27/convicted-killer-melanie-mcguire-seeking-post-conviction-relief-in-june-hearing/8153061/https://www.nj.com/middlesex/2014/09/suitcase_killer_melanie_mcguire_seeks_new_review_of_evidence.htmlhttps://www.nj.com/ledgerupdates/2007/07/prosecutors_mcguire_defense_wi.html See acast.com/privacy for privacy and opt-out information.

In this episode of Shaping The Future, I'm discussing the risks posed by Geoengineering in the context of averting worst-case climate change, with author Professor Bill McGuire. Bill's new book, Skyseed, is his first full length foray into writing fiction, from a distinguished career as Emeritus Professor of Geophysical & Climate Hazards at University College London as well as being one of Britain's leading volcanologists. Skyseed presents the reader with a narrative of when humanity's failure to address the climate crisis coupled with the political failure to say no to dangerous engineering interventions are gambled to reduce the impact of greenhouse gasses in the atmosphere. The scenario in the book is extreme but the story itself holds together very well as an existential consideration for where we are as an intelligent species on a living planet. Reducing our carbon emissions in every aspect of life, from agriculture to transport, travel, or heating our homes, is of critical importance in trying to stabilise our climate. Without an immediate thorough rethink, the risks of climate catastrophe, either by allowing global heating to run wild or by interventions that unleash any number of unintended consequences grow greater every day. Thank you for listening to this podcast. We are recording more interviews with a wide range of experts, so please do subscribe on any of the major podcast channels or Youtube, all accessible from climateseries.com. Buy Skyseed by Bill McGuire: https://amzn.to/3kd8IrN Find out more about the Cambridge Climate Lecture Series: https://climateseries.com/climate-change-podcast

The dismembered body of Bill McGuire is found in three separate dark green Kenneth Cole suitcases near Virginia Beach, Virginia. The medical examiner determines that the body had been shot multiple times. Now, 13 years later the convicted killer, his wife, maintains her innocence. Joining Nancy Grace today:Ashley Willcott - Judge and trial attorney, Anchor on Court TV, www.ashleywillcott.com Dr. Angela Arnold - Psychiatrist, Atlanta Ga www.angelaarnoldmd.comJoe Scott Morgan - Professor of Forensics Jacksonville State University, Author, "Blood Beneath My Feet" featured on "Poisonous Liaisons" on True Crime NetworkKristen Quon - WCYB Bristol, Va - ReporterJohn Glatt - Author of book about Melanie McGuire case, "To Have and To Kill" available on Amazon, www.johnglatt.com

Mike Max talks with Minnesota United Owner Dr. Bill McGuire on having to cancel another game due to COVID-19 and more. See omnystudio.com/listener for privacy information.

This episode of ABC's 20/20 covers the case of Melanie McGuire, who is defending her innocence from prison after the 2004 murder of her husband, Bill McGuire.

In a dysfunctional domestic froth of fertility, love affairs, and house hunting, Bill McGuire, a douche-bro with a need for speed, and Melanie Slate, an ambitious nurse with a cheating habit, are about to have a deadly divorce.

Between May 5th and May 16th, 2004, three suitcases washed up in the Chesapeake Bay. Each suitcase carried various parts of the same body. In the months after, prosecutors would attempt to paint a picture of a murderer motivated by jealousy, infidelity, and greed. This is the story Melanie and Bill McGuire, and the case of the suitcase killer.Join our Facebook Group, Kentucky Fried Cousins (Cause we're all family here!): https://www.facebook.com/groups/kyfriedcousins/For additional show notes, go to: https://kentuckyfriedhomicide.com

Owner of MN United, Bill McGuire tells Maxie what return to play will look like.

MN United owner Bill McGuire talks about getting soccer back to a place of playing but he also address the stress on the insurance companies during COVID and what this pandemic will do to health care costs.

Dr. Hayes interviews Dr. Lippman discuss on being one of the first translational scientists in solid tumors.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Welcome to JCO's Cancer Stories, The Art of Oncology brought to you by the ASCO Podcast Network, a collection of nine programs covering a range of educational and scientific content and offering enriching insight into the role of cancer care. You can find all of these shows, including this one, at podcast.asco.org. Welcome to Cancer Stories. I'm Dr. Daniel Hayes. I'm a medical oncologist and a translational researcher at the University of Michigan Rogel Cancer Center. I'm also the past president of ASCO. I'm really privileged to be your host for a series of podcast interviews with the founders of our field. In this series of podcasts, I'm hoping I'll bring appreciation of the courage, the vision, and the scientific background among the leaders who founded our field of cancer clinical care over the last 70 years. I think that by understanding the background of how we got to what we now consider normal in oncology, we can work together towards a better future for our patients and their families during and after cancer treatment. Today, I am privileged to have as my guest on this podcast Dr. Marc Lippman. Dr. Lippman was really instrumental in the early studies of the role of the S receptor in breast cancer. And personally, I consider him with his former colleague Dr. William McGuire the first investigators to perform what we now call, quote, "translational," end of quote, science in solid tumors. Dr. Lippman was raised in Brooklyn. He received his undergraduate degree at Cornell where, by the way, he played on the varsity tennis team. And then he got his medical degree at Yale. He did his residency at Johns Hopkins and returned to Yale for a fellowship in endocrinology. Somewhat surprisingly, to me at least, he served a year from 1970 to '71 as a clinical associate in the leukemia service at the National Cancer Institute while simultaneously working in the laboratory of biochemistry with Brad Thompson, with whom he published extensively. Dr. Lippman has authored nearly 500 peer-reviewed papers. He co-edits Diseases of the Breast, which is considered the Bible of breast cancer with Dr. Jay Harris and Monica Morrow and Kent Osborne. And fundamentally, he has mentored the leaders of breast cancer in the world, in my opinion. Welcome to our program. Hello. I have a number of questions I'd like to ask you. First of all, clearly, you took a really unusual path to being a cancer doctor. To my knowledge, you actually never formally trained in oncology. Can you tell our audience how you went from being an endocrinology Fellow to being an oncologist? I think it's worth it, from my vantage point, to give a little background about me. I came from very, very intellectually rich family. And there was never any question that I was going to do some kind of science. I was certain that that's where I was headed. And when I was in medical school, I think it's important that while everybody was doing research at the school like Yale, a lot of medicine as we now think of it as evidence-based was completely mysterious. In those days, when I was starting medical school, really, I think the only fully scientific field was infectious disease because we had Cox postulates. And we knew what drugs killed what bugs. And we knew what bugs caused what diseases, for the most part. And that was wonderful. But endocrinology, at that time, was completely functional assays. It was completely not scientific. You looked to see if the rabbit ovulated or something like that for a bio assays. And Nobel Prize winning research was done, which developed the radio immuno and the radio receptor assay. And that completely transformed endocrinology over night. And within about one year, virtually every endocrine disease, the pathophysiology of Addison's, thyroid disease, you name it was worked out based on being able to measure minuscule amounts of hormones. And to me, this was fabulous. I was going to be an endocrinologist. I had no doubt about it. This was real science. And I could get into it. When I was in medical school, you had to do a thesis. And for reasons that I'm not even sure of now, I can recall, I got involved with a guy who was a hematologist. But he did work on leukemia. And I enjoyed that work greatly. It was very interesting. And right about then, you may recall, there was a minor episode going on called Vietnam. And many physicians or people who were about to become physicians, myself included, weren't very anxious to go to Vietnam. And one of the main alternative routes was to become an officer in the public health service at the NIH and to do your military service at the NIH. And that seemed like exactly what I wanted to do. It was a very unusual process. People at the NIH picked you for their own personal lab. And because I had been working in this hematology lab, a scientist, an administrator actually at the NCI invited me to join his lab, Saul Perry. And I took him up on that because that seemed like my only alternative. But after I finished my internship and residency and showed up at the NIH, because I was part of Saul Perry's group which was the leukemia service, I had to spend a year on the wards taking care of extremely sick people, most of whom died during that year. But because of my love of endocrinology, I kept studying all kinds of stuff around endocrinology, took the molecular endocrinology courses. And then I met this wonderful mentor, Brad Thompson. And my first project with him actually was an attempt to combine leukemia and endocrinology. And I started measuring glucocorticoid receptors in leukemia. And that's, frankly, some of the best work I ever did. We showed that they existed, that they were receptors, and that they predicted response. I mean, we did in leukemia what people were doing in breast cancer, and I thought that was pretty interesting. And there was always this tension in my mind between the science of endocrinology and the almost complete lack thereof, at that time, in oncology. And I thought that I might try to think about putting them together. But I needed to do formal endocrine training. So after I finished my clinical year at the NIH and my two years in the laboratory with Brad Thompson, I went back to Yale to do endocrinology. And I thought that's where I would complete my career. After I'd been there about a year, Paul Carbone called me up and said, would I like to come back to the NCI and join the breast cancer service? And I have to tell you candidly, I had never treated a case in breast cancer in my life when I went to join the breast cancer program at the NCI. And I completely learned everything I learned about breast cancer absolutely on the fly. So what made Dr. Carbone call you to do breast cancer? Well, I'm not absolutely certain. I had done well at the NCI. I'd been very interested in a lot of things. And I'm not certain I can remember anymore. I don't remember why Paul called me, but he did. And at that time, I had been looking at several endocrine jobs at a variety of institutions, including University of Chicago. And I was thinking I'd just spend my life as an endocrinologist. But I thought this was such a great opportunity to pursue my research that I decided to take my chances. I was extremely full of myself in those days. And I didn't see the problem that I had never treated breast cancer. I know it sounds dumb to say it. But I actually said, well, OK, I'll figure this out. How hard can it be? And I guess I didn't find it all that hard. And at that time, because I had already gotten into what I would refer to as molecular endocrinology, half of which was steroid-hormone action, I was highly familiar with the work of Elwood Jensen, who was the real pioneer at that time, one of two actually. So naturally, it made sense to me to take the work I'd already done in glucocorticoid receptors and try to make models in tissue culture for how breast cancer responded to hormones, the kind of thing you would never suggest that a newly minted faculty member try a completely insane project, which I was extremely fortunate that it succeeded. You refer to Elwood Jensen. Tell us more about Dr. Jensen and what he did that got you where you were. Well, Elwood was a tremendous scientist and basically a chemist. And people don't understand how technology sometimes makes a field possible. And just as I mentioned before, radio immuno and radio receptor assay made the entire field of endocrinology and now so many other subspecialties of medicine possible as you measure pulmonary and GI and cardiac hormones, in the same exact sense, what Elwood succeeded in making was radiolabeled steroids. And you can't do receptor assays unless you have high specific activity compounds. We don't use radio isotopes touch so much anymore, and people don't appreciate that. But there was absolutely no way to measure the binding in picomolar and centimolar ranges without high specific activity steroids. And Elwood was able to manufacture created hexestrol, which is a similar compound to estradiol. And with that, he was able to basically separate bounds from free hormone and prove the existence of receptors. It was extremely important studies that he did at the time. And it opened up the entire field of hormone dependency in breast cancer, which, up until that time, had been based entirely on clinical criteria for response. And furthermore, what occurred almost simultaneously with that was finally the invention of some serious drugs that could interfere with hormone action, most notably tamoxifen but several others that were synthesized at the time. And so rather than just having to oblate organs or use very toxic super pharmacological doses of steroids to treat patients with breast cancer, there was now a readily obtainable and usable oral therapy. And so there was a tremendous need to figure out how and why it worked. And a lot of people got into that field relatively rapidly. Bill McGuire being among them. James [? Whitless ?] being among them, myself for sure. And all of us felt that this was an extremely important aspect. There was the clinical aspect, which became clear in the early '70s that there was, as you would expect, a very, very nice correlation between the presence of receptors and response. And that led up to the entire opening of this field of now that you could measure these receptors of how they worked, where they bound, what they did, what genes they induced. And so that became a lifetime exercise for many. My impression is that before about 1970, endocrine therapy, which dated back the 1890s, was mostly done by the surgeons. Did you have to muscle your way into that field? Or were they openly agreeable that some guy who had never even did oncology would start treating breast cancer patients? Well, I think that what was going on then, in England, there was a much greater delay in medical oncology as a field. And these patients were still treated by surgeons and radiation oncologists. I don't think there was any parallel issue in the United States. There were some very wonderful pioneering surgeons, but they didn't, I think, pretend to fundamentally want to get into molecular endocrinology. I don't recall that as being an area of conflict in terms of doing these kinds of studies. And of course, in this country, we were unbelievably blessed by the extraordinary, absolutely extraordinary pioneering and organizational skills of Bernie Fisher, tremendous scientist, in his own right, a tremendous surgeon, but, even more importantly, the ability to really form the most effective, ragtag, co-operative group the NSABP, which was able, from its very inception, to do some of the most groundbreaking studies not just around hormone therapy, which they certainly did, but obviously as we all know about, differences in surgical care. And so-- You eluded to Dr. Carbone. My impression is the NCI, mostly, in those days, was all about leukemia and lymphoma, the so-called gang of five, MOPP and CHOP and Doctors Frei and [INAUDIBLE]. Who was behind you to move out and start taking care of patients with cancer in a more scientific basis? Was it just Carbone or were there other people at the NCI who [INTERPOSING VOICES] Well, shortly after I got, there Paul left. He went to Wisconsin. And Doug Tormey, who had been nominally head of the breast group, departed. And so I was suddenly given an empty stage and said, well, why don't you do it? So within two years, I was running a program in which, the previous year, I hadn't even treated a patient. It was extraordinary. But right about that-- I was-- that's a very good question and a slightly personal one. About 30. About 30, 31. Yeah. Most 30-year-olds now are just starting their residency or their fellowship. Right. And it is unfortunate that people with the most energy and most intelligence get increasingly pushed downstream. I mean, the age of first RO1s in this country is horrible, as we all know. And that's a major other problem that people need to address. But at that time, as you may recall, several groups were developing the first multi drug combinations for breast cancers. CMF, or as Johnny [INAUDIBLE] used to refer to it as CMF, and of course other variations with the MD Anderson regimens of so-called FAC chemotherapy, F-A-C, and other regimens that included vinca and prednisone. And so for the first time, reasonably active regimens were available for metastatic disease. Where in the past, it had only been a handful of single agents, vinca, methotrexate, 5-FU. And at the same time, I think there were the extraordinary, a little bit later, the extraordinary first data that adjuvant therapy was successful. I mean, the studies done by the NSABP initially was single agents and then the CMF studies from Milan were extraordinary. I mean, breast cancer was and remains the most tractable of the solid tumors with the possible exception of testicular that we've treated in this country or anywhere. Tell us about your lab work and how you established what you did, and then really interested in how you looked at what you were doing in the lab and said, jeez, this relates to my clinical work. Well, thank you. As I said, when I had been working at Yale before I came back to the NCI. And at that point, at Yale, I was trying to develop models of gluconeogenesis in liver cells. It had nothing to do with cancer. And so I arrived at the NCI, recruited by Paul, offered some laboratory space, and said, go to it. And I literally, literally scratched my head and said, well, what am I going to do now? And because I hadn't had a previous thing I was just going to expand on. And because another great miracle that had been growing from very late '50s to the mid '60s was cell culture. I don't think people can now imagine how pioneering the results were to grow cancer cells and to get them to reflect, in any sense, the phenotype of human malignancy. I mean, now we take it for granted. But these were pioneers trying to figure out how to grow cells, Harry Eagle and Hamm and Dulbecco, and all of these other wonderful people. So anyway, it seemed to me, wouldn't it be great, since someone had described a cell line that had estrogen receptor, I said to myself, what would be more straightforward than to figure out how you could manipulate these breast cancer cells with hormone therapies and figure out the mechanisms by using cell culture as a model for steroid hormone action? So I set about doing that. And after about six months, I succeeded. And that was the good news. And ironically, the better news was that nobody else could reproduce it, including Dale McGuire. And lots of people said this was, frankly, garbage, that I was making it up. And so when eventually-- no. It was very upsetting. I don't think many people when they first start off and they have their first big set of papers, and I published this stuff in Nature and serious journals. And all of a sudden, everybody says, it's not true. I remember giving a lecture at Harvard. And somebody at the end at the questions said, we just can't reproduce this data. We don't think you're telling the truth. I mean, how often you want to have that happen in your career? And as I said, what turned out to be very fortuitous was that we were right. And so eventually, that made things even easier for me in terms of my career. There's no question about that. And a lot of people wanted to go to the NIH. I think it's now with so many wonderful-- what are there more than three dozen comprehensive cancer centers? But the United States in those days, there were just a handful. And most of them were doing leukemia and lymphoma, like Stanford, which certainly had almost no breast cancer program at the time. And so people who wanted to work in breast cancer came to work with me. And lots of people wanted to get a BTA degree, Been to America. So I was fortunate to have some very outstanding people from Europe and Asia come to participate in my work. And there was still the tail end of Vietnam. So some of the very best and brightest, if I could misuse that expression, people like Neil Rosen and Ed Gellman and Doug Yee and George Wilding, people who all became cancer center directors were people that I was very fortunate to have work with me. And I was pleasured to deal with them. When did you say you were doing the lab models of cell lines and discovering how ER mediated the effects of estrogen? When did you start saying, let's take this over to the clinic? I mean, what was the first thing you did that you translated into the clinic? Well, the first translational study I did when I was a fellow when I tried to do correlations of response to glucocorticoids in leukemic patients and ALL and AML. So I mean, I was used to going back and forth that kind of way. And we did a series of drug trials in breast cancer patients. I was seeing patients. I haven't spoken much about it. But I don't know how to say that any other way whether it sounds modest or not. I simply love being a physician. I found that the main appeal of oncology was dealing with people at times of enormous obvious stress and disturbance in their lives. And I found that that brought out some of my best skill sets. And so I was anxious. I was always involved with patients like that. One of the main trials that we got involved with involved Allen Lichter because Allen and I were endlessly discussing what was the right therapy for localized breast cancer. You may recall that Sam Hellman, the joint center, refused to be part of clinical trials looking at lumpectomy and radiation, as he was convinced, turns out correctly, that that was equivalent to doing mastectomy. And we felt, Allen and I, I think somewhat maybe arrogantly again, that we could do a single institution trial for lumpectomy versus radiation. And we did. We ran a randomized trial of about 350 women at the NCI, a prospective randomized trial of lumpectomy and radiation versus chemotherapy. And of course, all of these patients became fodder for advanced disease trials and everything else we were doing. And those are some of the happiest days of my life working with Alan side by side in what may have been the first multidisciplinary clinic in breast cancer. If I may, I'm going to interject. Allen Lichter, who started the department of radiation oncology at the University of Michigan, where I'm sitting right now, was my dean when I arrived here, became ASCO president at one point, and then was the ASCO CEO for years. Since this is an ASCO publication, if you will, I'd give him credit for all of that. And well he deserves it. Well he deserves it. Yeah. I can't agree more with that. That's for sure. The other thing I've heard you-- by the way, I've always wondered. How did you get 350 patients onto that trial at the NCI, since you've tended not to see walk in the door kind of breast cancer patients, right? So how did you? Well, the NCI remember, everybody was treated free. So fortunately or unfortunately, given American medical economics, people who had a diagnosis would come to see us because they had no other option. We would pay all their travel and everything else. So we treated patients. And I have to tell you, up until last year when she died, I still had patients from that study who had followed me around the country to be treated. That's a great story. It's true. It's absolutely true. So the other thing I've heard you talk about, and I think people should-- given the proliferation of medical journals now, there's one on every corner, I've heard you talk about the fact that you really have a hard time finding places to present your endocrine results, that the Endocrine Society didn't care about cancer. And AACR didn't care about endocrinology. ASCO didn't really exist almost in those days. Give us some stories about that. Well, that's completely true. It's completely true. There was always a session in the Endocrine Society called cancer and hormones, which was late on Friday afternoon. And everybody had gone home. And AACR had the same thing. Because at that time, there just wasn't an obvious niche for cancer. What began to make it more popular to both societies were when things like, quote, "growth factors," close quote, became more in evidence. And they clearly played a role in cancer. But clinical trials and clinical experience had no role in the Endocrine Society. And basically studies in molecular oncology just didn't seem all that attractive to AACR. It wasn't like you couldn't talk about it. It just wasn't front and center what people were interested in. Everything goes through vogues periods. We're now going through an immunooncology voguish period. And I'm not trying to suggest that that's not extremely important and going to have endless value for people. But now, if you're doing almost anything else, you can't even write a protocol. It's true. It's true in some ways. I was trained. [INAUDIBLE], who's an endocrinologist, was at the Dana Farber and told me that cancer is just endocrinology gone wild. In fact, I believe, in many respects, that's what precision medicine is all about is that we begun to take what you guys did 50 years ago and said, let's do it for all the diseases other than immunology, which is a different issue. I agree with you. I think that that's a good point. I think that one of the fundamental differences between normal and cancer, however, is genomic elasticity. If you had psoriasis, and I put you on methotrexate. Then 10 years later, I doubled the dose, it would kill you. Because you never amplify the target gene, dihydrofolate reductase. And you remain sensitive throughout your entire life. Whereas doing that with a leukemic cell, in a couple of months, you'd be completely resistant. And that is, in my mind, one of the shortcomings of so-called precision medicine in which you're trying to match a pathway, an oncogene, to a specific therapy. In that, oftentimes, these studies are in end stage patients with multiple resistant clones now has become endlessly clear from single cell sequencing studies. And I think that there is, I think, personally, slightly less to most efforts in precision medicine than most people think. And I believe that it's amusing that precision medicine has come to include immunooncology, which has little, in my mind, to do with the initial way in which precision medicine was touted, which is find the oncogene. And we will give you the drug. And I think, by and large, that, except for some incredible successes like Gleevec for CML, hasn't really panned out. Personally, I think what we're going to do is head back to what doctors Hall and Frei and [INAUDIBLE] taught us, which is that resistance is a heterogeneous issue, and we need to combine drugs. We just need to do it more thoughtfully than perhaps we've been doing in the past. Couldn't agree more. I want to change the paths for just a moment. To my knowledge, you are one of the few and maybe you were the first oncologist who's been both a cancer center director at Georgetown's Lombardi Cancer Center but also a chair of medicine. You've been at two major academic centers, here at the University of Michigan and University of Miami. Why do you think there have been so few oncologists who have been chiefs of medicine, chairs of medicine? Well, your personal favorite institution, UT Southwestern, would be an example as well of a chair of medicine who's an oncologist. Right. But no particular reason comes to mind. I think that the skill sets and interests of a chair of medicine, at least as it used to be, up until maybe about 10 years ago, were someone who actually wanted to, A, have somewhat less of a research footprint, which would discourage some people, and something less of the same focus on curing a specific disease, which would certainly describe a cancer center director. And I think that exactly explains some of my clinical interest in becoming a chair of medicine at Michigan. I went there, there are always push and pull reasons. The push reasons were that Georgetown was economically a disaster. And they had sold both the hospital and the clinical practice to a large non-profit community-based hospital. And I thought that would be, more or less, the end of the cancer center as I knew it in. And unfortunately, that prediction turned out to be, in many ways, correct. So there was push issues. I just didn't want to officiate over the deconstruction of the cancer center that I had helped to build. And in addition, I felt clinically, I was raised in the era of great chairs of medicine. I was raised in the era of Don Seldon and Dan Foster and A. Magee Harvey, and people who knew everything and would teach at the bedside and knew everything about disease. And frankly, I felt that breast cancer clinically, not emotionally and not from a research point of view, but clinically is relatively straightforward and not that complicated. And I wouldn't say I was bored. But I was looking for a new challenge. And I thought the notion of really trying to bring other areas to bear in terms of my research would be fun. And so I was thrilled to be chair of medicine. But I don't think that's necessarily the career path that many oncologists or any other subspecialist would want. Which did you enjoy most, being cancer center director or being chair of medicine? Unquestionably, being cancer center director here at Georgetown. It was the thrill of a lifetime. When I came here, there were three people in the division of hematology, oncology. Two of them immediately left. And by the time I moved to Michigan, the Department of Oncology that I had created had more faculty than all of the basic science departments at Georgetown combined and more research money than all of the basic science departments at Georgetown combined. It was tremendously happy, very successful. And I felt we were doing really wonderful things. It was just a fantastic time, just like that, which is one of the reasons why I've come back. And I was going to say, although Georgetown did fall on hard times. My opinion is grown back into a major institution. And I'm sure they're happy to have you back. So we're running out of time. I really just touched the surface of many of your contributions. In addition to your scientific contributions, you really touched on it. You've been one of the most prolific mentors in our field in my opinion. I looked over your CV. I count at least six cancer center directors. I think five, four PIs and probably hundreds of others who are proud to have been under your watchful training eye, by the way, including myself, in our careers. So of all the things you've done, your science, your administration, your mentoring, we've touched on all three of those. How do you want people to remember Mark Lippman when it's all said and done? So there's a wonderful joke about that. These three guys are standing around saying what would they like to hear said around their coffin when they're dead. And one guy was a teacher, and he says, you know, I'd like them to remember what a wonderful teacher I was, how I helped people. And another guy's a physician, and I'd like to hear if I'm lying in my coffin, them say, what a wonderful physician. He did everything for his patients. The third guy says, what I'd like to hear is, look, he's moving. So it's hard to-- right. I am certain that the place that I feel most happy, it's not even a close call, is the ability to have played an important role in helping people's careers succeed. I mean, I'm something of a tough guy. But I have been, I feel, very willing to see people grow up and leave the nest and keep them nurtured and look after them for many additional years in their career and enjoy those relationships. It's incredibly enriching. Well, I also have to say there are hundreds of thousands, if not millions of women who have benefited from the contributions you and your colleagues made 50 years ago at the NCI and since then. I've tried to make it clear through all these podcasts how much we owe all of you for what you've done and where we are now. And the reason we're doing this is so people don't forget about those things as we move into medical economics and some of the other things that I think are less fun. So it's time to conclude here. I want to thank you for taking your time. And again, thank you for all you've done for the field, for those of us who've trained with you, and again, mostly for our patients. And I hope you've enjoyed this conversation as much as I have. Very much, Dan. Thanks for including me in this podcast. Until next time, thank you for listening to this JCO's Cancer Stories, The Art of Oncology podcast. If you enjoyed what you heard today, don't forget to give us a rating or a review on Apple Podcasts or wherever you listen. While you're there, be sure to subscribe, so you never miss an episode. JCO's Cancer Stories, The Art of Oncology podcast is just one of ASCO's many podcasts. You can find all the shows at podcast.asco.org.

Wes sits down with #MNUFC owner Dr. Bill McGuire to talk about stadium development, 2019, the technical staff shakeup, and the future of Minnesota United.

Happy New Year! It is totally our goal this year to come back better than ever! Our reality shows were on a hiatus last week, so we're back today with a new true crime episode about the murder of Bill McGuire, a software analyst at NJIT who was never reported missing until his remains were found in three separate suitcases hundreds of miles away from home in the Chesapeake Bay. Suspicion immediately turned to Bill's wife, Melanie, who was having an affair and planning on leaving her husband. Was Melanie responsible for Bill's murder? Tune in to hear all of the evidence in this case and our thoughts on the outcome. We will be back on Friday with a new tv time episode on the new season of THE BACHELOR!! We can't wait to discuss all of Pilot Pete's ladies on the upcoming season. Until then, thanks so much for listening! IG: winecrimetvtimepod FB: Wine, Crime, & TV Time Podcast --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Episode Notes In the far future, beauty and confidence are used to determine station.Contact info for Bill McGuire Website---- Story Submission ----Got a short story you'd like to submit? Submission guidelines can be found at TallTaleTV.com---- About Tall Tale TV ----My name is Chris Herron, and I narrate audiobooks.In 2015, poor control of my diabetes left me legally blind for the better part of a year. The doctors predicted an 80% chance I would never see again, but I changed the way I was living and through sheer willpower beat the odds.During this time I couldn't read or write. Two things that I had been turning to for comfort since I was a small child. With the sheer amount of stress I was under, this was devastating. My wife took me by the arm, lead me into the local library, and read out titles of audiobooks to me. I chose the audiobook versions of books I had loved such as the Disc World series, Name of the Wind, Harry Potter and more. They brought my favorite stories to life in ways I never thought possible and helped me through the darkest time of my life.Once my vision recovered, I maintained a love for audiobooks. I decided I would turn my focus from being a writer to becoming a narrator. I devised Tall Tale TV as a way to help out all the amazing authors in the writing communities I had come to love before my ordeal.I created Tall Tale TV to help aspiring authors by providing them with a promotional audiobook video. A way to showcase their skills with the written word. They say the strongest form of advertisement is word of mouth, so I provide a video to a platform of readers to help get people talking. Help them spread the word.Click the share button and let the world know about this author.---- legal ----All images used in this video are either original or Royalty and Attribution free. Most stock images used are provided by http://www.pixabay.com . Image attribution will be declared only when required by the copyright owner. All stories on Tall Tale TV have been submitted in accordance with the terms of service provided on http://www.talltaletv.com or obtained with permission by the author. Common Affiliates are: Amazon, SmashwordsFlair Flair is shown at the bottom of your show notes when your listeners see it in their podcast app and on your podcast website.Powered by PinecastPinecast referral code Show feedback prompt Show more optionsTerms Privacy Blog Help

Welcome to Crawlspace. In this episode Tim Pilleri and Lance Reenstierna chat with Meghan Sacks and Amy Shlosberg of the podcast Direct Appeal about convicted killer Melanie McGuire and the murder of Bill McGuire. Did she do it? Check out Direct Appeal: https://directappealpodcast.com/ Apple: https://podcasts.apple.com/us/podcast/direct-appeal/id1462493685 Stitcher: https://www.stitcher.com/podcast/direct-appeal Spotify: https://open.spotify.com/show/3Ri7yzCO33V0er61dIPXew?si=BhiRyy9NQJmdi2KRPLmeBw Sign up for our Patreon page at https://www.patreon.com/crawlspacepodcast. Five bucks a month gets you access to new content every week. Check out the new Crawlspace Discussion Facebook group: https://www.facebook.com/groups/talkcrawlspace/ Follow Missing Maura Murray: Twitter: https://twitter.com/MauraMurrayDoc FB: https://www.facebook.com/MauraMurrayDoc/ IG: https://www.instagram.com/missingmauramurray/ Youtube: https://www.youtube.com/MissingMauraMurray Apple: https://podcasts.apple.com/us/podcast/missing-maura-murray/id1006974447 Stitcher: https://www.stitcher.com/podcast/missing-maura-murray Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri Check out Criminal Perspective with Chris Duett and Andrew Dodge! Apple: https://podcasts.apple.com/us/podcast/criminal-perspective/id1471068303. Stitcher: https://www.stitcher.com/podcast/criminal-perspective. Patreon: https://www.patreon.com/criminalperspective/posts. Twitter: https://twitter.com/crmnlprspctv. Instagram: https://www.instagram.com/criminalperspective/ --- This episode is sponsored by · The Colin and Samir Podcast: The Colin and Samir Podcast hosted by LA - based friends and filmmakers Colin and Samir takes a look into what it’s like to make creativity your career. https://open.spotify.com/show/5QaSbbv2eD4SFrlFR6IyY7?si=Dj3roVoJTZmOime94xhjng

It was a dark green suitcase. Given its proximity to the bridge, the men assumed it must have blown off the luggage rack of a vehicle driving above and hauled it onboard... Episode narrated by the Anonymous Host (https://twitter.com/casefilehost) Episode researched by Flossie Arend Episode written by Flossie Arend, Elsha McGill, and Milly Raso This episode's sponsors: Never Thought I'd Say This (https://audioboom.com/channels/4995112) – New parenting podcast from Audioboom starring Jodie Sweetin and Celia Behar Quip (https://www.getquip.com/casefile) – Get your first refill pack FREE with a QUIP electric toothbrush Grove (https://www.grove.co/casefile) – get FREE Mrs. Meyer’s Set worth $30 with your first order of $20 or more Calm (https://www.calm.com/casefile) – Get 25% off Calm Premium subscription For all credits and sources please visit casefilepodcast.com/case-120-bill-mcguire (https://casefilepodcast.com/case-120-bill-mcguire/)

03: Bill and Melanie manage to piece together their relationship after dealing with tumultuous times.  They forge ahead with their dreams of owning a home in the suburbs of New Jersey even though their relationship is not entirely a happy one.  They find a home and close on it April 28th, 2004, but Bill McGuireContinue reading The Closing →

The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care, and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Welcome to Cancer Stories. I'm Dr. Daniel Hayes, a medical oncologist. And I'm a translational researcher at the University of Michigan Rogel Cancer Center. And I'm also the past president of ASCO. Over the next several podcasts, I am privileged to be your host for a series of interviews with the founders of our field. Over the last 40 years, I've been fortunate to have been trained, mentored, and frankly, inspired by many of these pioneers. It's my hope that through these conversations, we can all be equally inspired by gaining an appreciation of the courage, the vision, and the scientific understanding that led these men and women to establish the field of cancer clinical care over the last 70 years. By understanding of how we got to the present, and what we now consider normal in oncology, we can also imagine and work together towards a better future, where we offer patients better treatments, and are also able to support them and their families during and after cancer treatment. Today, I am very pleased to have as my guest on this podcast, Dr. John Minna. John is generally considered one of the pioneers of translational research in solid tumors, and he's widely recognized as a leader in lung cancer. Dr. Minna is currently the director of the Hammond Center for Therapeutic Oncology Research, and Professor of Internal Medicine and Pharmacology at the University of Texas Southwestern Medical Center in Dallas, where he also holds the Max L. Thomas Distinguished Chair in Molecular Pulmonary Oncology, and the Sarah M. and Charles E. Seay Distinguished Chair in Cancer Research. Dr. Minna received undergraduate medical degrees from Stanford in the mid-1960s, which were followed by a residency at Harvard's Massachusetts General Hospital in Boston. He then went to the NIH, and the National Heart, Lung, and Blood Institute for his fellowship in biochemical genetics at the NIH with Dr. Marshall Nirenberg. And then he stayed at the NHLBI as the head of the section on somatic cell genetics. In 1975, he became chief of the NCI-VA Medical Oncology branch within the Clinical Oncology program of the Division of Cancer Treatment. And in 1991, he then moved to University of Texas Southwestern in Dallas, where he served as the director of the Sammons Cancer Center and Chief of the Division of Medical Oncology for four years. And since, he has held his current position. Doctor Minna has authored over 700 peer-reviewed papers, and well over 100 other reviews, book chapters, and educationally related manuscripts. He's won too many awards and honors for me to go through in detail. But these include the AACR's Rosenthal award, and ASCO's Scientific Achievement Award, two of the highest in those two organizations. He's also received the ASCO Statesman Award, and he's served on both the AACR and the ASCO boards of directors. He's been PI of the combined UTSW and M.D. Anderson Cancer Center Lung Cancer Specialized Program in Research Excellence. And in 2015, he was named one of the Giants of Oncology by OncLive. Dr. Minna, that's quite a mouthful, though. Welcome to our program. Thank you so much, Dan. And thanks for all your work in ASCO and everything, too. Well, actually, it was, as you can imagine, a great privilege. I just had a fabulous time. Just as an aside, when I got elected, I interviewed about 10 former presidents. And at the end of each of my set of questions, I said, well, fill in the blanks. What do you want to talk about? Almost everyone of them said the saddest day of their career was the day they had to quit being president of ASCO. And I know that now. Anyway, now I know you went to Stanford. Were you always a California boy? Or how did you get to Stanford? Well, yes. I was born in San Francisco, actually at the Presidio, which is now a fancy movie set-- some of the priciest real estate. And then, my dad was in the Army. My mom was a nurse. And then I grew up in San Diego. And my Dad had the largest family practice in San Diego. And my mom was the nurse that ran the office. I never forget, I called them one day when I was an intern at Mass General and complained I had 25 outpatients that I saw that day. And they laughed. They'd seen 80. And I made maybe 500 house calls with my dad, carrying his bag when I was younger. And so, he obviously was in medical school just before and then right after the Depression. And so, he had had an opportunity. He was going to do a fellowship in pediatrics at Harvard, but couldn't do it. He had to support all his parents and everything. And, by the way, he had immigrated from Italy when he was a kid. So this was quite a story. And so they always encouraged me to go into academic medicine. It was interesting, because all his buddies were surgeons that kept telling me to come back and be a general surgeon in San Diego. So anyways, I grew up in San Diego. And then was lucky enough to get into Stanford undergraduate medical school. So I went back and looked at your publication list, which dates back to the mid-1960s. By the way, I was in junior high then. It looks to me from your list of publications that you weren't originally headed to a career in oncology. In fact, it looks like you were doing genetics. So you've done a lot in lung cancer. Tell us what happened at the NIH that you sort of changed gears and went into lung cancer. Well, actually, the cancer decision was actually made back in medical school. And it was those-- two of the people that you mentioned when we were talking before, Henry Kaplan and Saul Rosenberg, that really inspired me at Stanford. And they both took me under their wing. I remember the last six months of medical school I spent full-time on radiation oncology. Actually, I worked up nearly 100 new patients with Hodgkin's, if you can imagine that. It's all because of the clinical trials going on there at Stanford. So there were all these new patients coming in. So both of them absolutely got me committed to a career in cancer way back in medical school, and then helped get me internships, residencies. It was Henry's letter to get me a position with Marshall Nirenberg. But both of them were instrumental. And they took a group of young people-- another person that was a year behind me was Ron Levy, obviously, a very prominent person in oncology. And there was a group of us at Stanford that they took under wing. And so as medical students, we were going to these clinical protocol conferences in cancer, which probably didn't exist anywhere else in the United States at that time. And it was just amazing to see the two of them work together-- totally different personalities, but extremely skilled clinically and in terms of clinical trials. So that was an exciting time. And so the decision for me was made way back there when. And as part of it, at Stanford Medical School, I was fortunate enough to do my research in the Department of Genetics. And the person that took me under his wing there was Leonard Herzenberg, who was the guy that invented the fax machine. Obviously, probably should have won the Nobel Prize for that. And so it was kind of genetics on the one side, and cancer on the other. So you can see how that kind of evolved going forward. What struck me at Mass General was that there were fantastic clinicians and everything. Obviously, a lot of cancer. But nobody wanted to take care of the cancer patients in Mass General. So an intern resident, I kind of volunteered for all of that. And then when I got to the NIH with Marshall, it was more genetics and everything. And we can talk about that. But I realized after five to seven years there I was either going to be a basic researcher, or get back to my clinical love. And that would have been cancer. So those were the ties that brought genetics and cancer together for me. So can I ask you, when you were in Boston, who was the chief of medicine at Mass General? Oh, gosh. [INAUDIBLE]. The real question I'm asking is, had Dr. Farber's work filtered across town to you guys? That was just about the same time he was starting to give chemotherapy to kids over at Children's. Right. No. Obviously, they knew about it. But it really wasn't discussed at all there. And there was obviously a separation between what was going on at Farber and the Brigham and then at Mass General. Now, obviously, things are much more integrated. So what made you go into lung cancer after you got to the NIH? I think it was Vince DeVita. But it happened because I actually-- so I'd been with Marshall and they had given me my own group to work with there that we mentioned. And I'd been working on somatic cell genetics. And so I went to Vince and I said, look it, I have to do an oncology fellowship so I can learn about this stuff now and get ready. Of course, this is-- the boards came in '75, which were later. And so he said, well, John, I'm not going to do that. But I tell you what. There's this branch of the VA hospital that [INAUDIBLE] [? Anson ?] and Frank [INAUDIBLE] and [INAUDIBLE] are running. And I'm trying to decide whether or not to shut it down. So I tell you what. Why don't you go down and run that? And then you'll kind of learn on the job. And, of course, being 35, 36 years old, you think you can do everything. And I said, well, who's the staff there? And he said, well, they're all leaving. And fortunately, one guy [AUDIO OUT]. So I said, well, who are the fellows coming out of the program that are the best fellows? He said, well, that's easy. It's Dan [INAUDIBLE], Paul Bunn, and Jack McDonald. And so I said, well, if I go talk to them, will you at least back me up? And so I did. And fortunately, two of the three agreed to come. I said, you're going from being a fellow to being a senior investigator here in one fell swoop. But this is it. Jack went with Phil [? Stein ?] and did all the work on GI. Phil was leaving the NCI to go down to Georgetown. So they did that. And fortunately, Marty Cohn was down at the VA. He is fantastic clinical trials [INAUDIBLE] and done work with lung cancer. And we did all of that. And so, we went down there. And so, I said, well, OK, got to work on lung cancer. And so we've got to then start working on the genetics of lung cancer. Of course, everybody said that was totally stupid and not possible. And fortunately, I had my collaborator who had been part of the oncogenic virus program, a pathologist, Dr. Adi Gazdar [INAUDIBLE]. So I said, Adi, come on down, and we can do that. So there was people that really gambled on me. Yeah. I wanted to talk about your association with Adi. Before I get to that though, what were you doing for lung cancer in the mid '70s? It must have been pretty crude. Well, we thought it was pretty sophisticated. And, in fact, what we-- obviously, there was the whole series of the first phase of small cell lung cancer clinical trials. There were first reports that occasionally patients respond, have these dramatic responses. And so we set up these whole series of trials. And, of course, at that time, nobody out in the private world wanted to take care. So these patients would come flooding in. And we would do all the staging, get their tissues, and then try to start cell lines from them that nobody had been able to that before. But then they all went on to randomized clinical trials. And Marty Cohn played a big role in that. Obviously, Dan [INAUDIBLE] and Paul Bunn were instrumental. Des Carney came on. And so, these were various combination therapies that [INAUDIBLE] essentially leukemia-like treatment. But Vince always thought the reason we weren't in small cell lung cancer was that we weren't tough enough. And I kept saying, Vince, we're getting-- we're putting them in isolation. We're treating them with more intensive regimens than with leukemia. And so odd responses, but not. And then the other important component of that was Eli Glatstein's recruitment to the NCI as head of the NCI radiation oncology branch. And he really was-- I mean, briefly had known each other at Stanford. And because we were both tied to Henry Kaplan, that made Eli and me instant friends. And basically, we were like brothers. And so he totally threw the support of the radiation oncology branch behind that. And then there were a series of trials with that. Allen Lichter, former president, obviously, and Joel Tepper, he [? added ?] parts to that. So that was fantastic. Anyone from-- So it must have been pretty exciting for you to see some of the first complete responses with chemotherapy in a solid tumor with a small cell. Absolutely. And that's what-- you know, at that time, and particularly then when we started putting this with limited stage, we were really hoping there was going to be a big tail on the survival curve with people who got put into complete remission being able to remain there. And obviously, the therapies would combine modality with chemo and radiotherapy were complex, too. And we were very fortunate to have the various skillful skill set from the radiation oncologists to work with that. And then in '81, by the way-- so we were at the VA from '75 to '81. And then from '81 to '91, it was the NCI-Navy Medical Oncology Branch, when Vince moved us all up to the new National Naval Medical Center. So you and Dr. Gazdar obviously have had a decades-long collaboration. And how did the two of you even hook up? Was it just because you were providing specimens to him in the pathology lab? Or-- No, no. It all actually started five or six years before. We were-- as part of the somatic cell genetics effort is-- I don't know if you remember, there was also a big effort in terms of isolating tumor viruses and the study of retroviruses. And it turned out that the genetics that I was doing with somatic cell genetics could be used to map receptors for retroviruses. And so he and I collaborated on studying the genetics of RNA viruses in human cells and assigning the various linkages to different chromosomes. And so when, again, as I said, when Vince offered me this battlefield promotion, I knew were going to need a laboratory thing. So I said, Adi, come on down. I said that we were going to have to-- we can't study viruses. We're going to need to study something else. And it's going to probably be lung cancer. And so he agreed. And obviously, he has trained as a pathologist, even better part. And he's now, obviously, one of the world's leading lung cancer pathologists. The other person that was at the VA whose name you may not know is Dr. Mary Matthews, who is a pathologist. And she did a lot of the first VA studies, actually determining that small cell lung cancer was highly metastatic, even when it appeared to be localized. So she was-- I've seen her work. Yeah. Actually, so you were there when viruses were going to be the cause of every cancer. Did you get a lot of pushback if you began to say, I don't think that's the case? Well, it's kind of what goes around comes around. We didn't-- no. As it turned out, it was oncogenes that are cause of cancer, which were discovered through Bishop and [INAUDIBLE] thing too. But you do know the other interesting connection with us and viruses and cancer is that we were obviously studying lung cancers and patients and that. But then, Paul Bunn was extremely still interested in lymphomas. But the way the politics, the Onco politics at the NCI intramural program went, that was already the domain of the medicine branch, Bob Young's branch-- Bruce [? Jander ?] and Dan Longo and Bob Young. But there was one lymphoma that they absolutely wanted to have nothing to deal with. And that was Sézary syndrome mycosis fungoides. So Paul said, OK, we're going to study mycosis fungoides. So both at the VA and at the Navy, we had just huge numbers of patients with [? MF ?] come in. And that involved a variety of studies with electron beam and various therapies and staging that Paul was a major figure in. Well, as part of that-- so we started cell lines, tried to start cell lines from those as well. Well, the other thing that was happening was Bob Gallo's discovery of IL-2, T-cell growth factor. And so we got some of that from him, and were able to study, to grow several of these. And it turned out, one of these was from a young patient with highly aggressive HTLV-1 disease. It was a young black guy from the South. He had one of the first-- you know, his bone scan was a super scan with [INAUDIBLE]. Now, we know. So we didn't do that. And it turned out that Bernie Poiesz was a fellow rotating with us. And he went back to work in Gallo's lab and took those cells. And, of course, Gallo was searching everywhere for oncogenic viruses and retroviruses. And the super [? agent ?] from this cell line, H102, blew the roof off. And it turned out to produce HTLV-1. And that was [INAUDIBLE]. Actually, Henry Kaplan submitted for us to PNAS that was with Bernie and Bob Gallo. And that was the first human retrovirus that was discovered. And then it turned out there were other patients that we had, obviously with T-cell lymphomas, that didn't produce virus. But it turned out that those were ones that the virus could replicate in. And that leads off into a whole separate story that you probably need to talk to Adi Gazdar about, because he started this line. And that's the whole Bob Gallo thing. But the point is that Bob knew that if you could get a T-cell line to grow, it could make the retrovirus, and you could identify it. And so, he kept trying to grow T-cells from patients, at that time young, gay guys from New York and San Francisco. Of course, nothing would grow because they were all being killed by HIV. But there were these T-cell lymphoma lines that had that property. So, in any event, this whole thing came back to viruses, that-- it's not my [INAUDIBLE] study. But it was Adi's and Bob Gallo's. You know, you've through this talked a lot about the basic science and the observations. And the term translational medicine really hadn't been invented yet. But you, and I would argue, Marc Lippman and Bill McGuire in breast cancer, were really some of the first to span the gap between [INAUDIBLE] in the clinic in solid tumors. My impression is leukemia and lymphoma had been going on, but it was the solid tumors where you made your big step. Were you thinking about that the whole time? How can I take this and take better care of Mr. Smith or Mr. Jones? Were people trying to stop you from doing that? Who was your role model to give you the courage to move forward? No. I think if you were present back at the NCI-VA and NCI-Navy, it was pretty clear-- and this didn't require any set of smarts-- that the whole idea to start these things was to have models that you could then test to see about new therapies in order to find out what were the underlying causes. And so you remember back there was the [? Amberg ?] and Dan Von Hoff assays for tumor cell sensitivities. So a lot of our first studies were looking at drug response and radiation response phenotypes. And one of the interesting first things was that the small cells, most of them were exquisitely-- they were like lymphocytes, sensitive to radiotherapies, which was what it was like in the clinic. So I think that there was probably kind of obvious some of the things to do. I think the obstacles were-- first of all, the major obstacle was everybody blamed the lung cancer patient for having lung cancer because they smoke. And I'm sure Franco and anybody working in the lung cancer field with Franco Muggia would tell you this. And we're finally over that, I think, and also with the never smoking lung cancer cases. So that was one big obstacle. I think having these models to work with was another. And then just having the genomic techniques to study them. I look at our first publications in Nature with Southern blots and a few samples. And now, you couldn't even-- this wouldn't even qualify as supplementary supplementary data. Actually, I don't know if you were at ASCO. Bruce Johnson's presidential address was an elegant description of the progress made in lung cancer. And he showed pie charts of 10 years ago. And the entire treatment was chemotherapy. And now it's broken up into all the different precision medicine and immunoncology. I've got to think if you were in the audience, and if you weren't, that's fair. But if you were sitting here thinking, boy, shake my head. We've made a lot of progress. Oh, [INAUDIBLE]. Well, I tell you, I get-- some of those slides I know Bruce was-- I was giving those to Bruce. So, you know, clearly, those were the types of obstacles. And everybody thought that-- first of all, everybody thought that lung cancer was not a genetic disease. And in retrospect now, it's obvious. But, you know, so I think there's that-- the technologies. So one brief anecdote about-- and you probably saw this, too, at the Farber. I'll never forget at the NCI-Navy, all of the senior staff rotated. And we had several months worth of attending in there. And we were taking care of patients with all kinds of tumors-- breast, lung, everything. And we had our own ward with 40 beds. And we saw about 70 patients elsewhere in the hospital. And we had 100 patients a day in clinic. So it was a huge service. So I go up, and I'm doing my first day of attending. And I introduce myself. And I'll tell you who my fellows were on that round. So one of them was Nancy Davidson. The other was [INAUDIBLE]. The other was Neal Rosen. And one was George Morstyn, who subsequently became a-- Australian guy became a VP at Amgen. And so they're presenting these cases and everything. And I go back, and I sit down with Paul and [INAUDIBLE] and Dan [INAUDIBLE]. And I say, Jesus. I said, I can't believe it. We have some really good fellows this time. At another time offline when it's not recorded, I'll tell you some of the presentation that Neal Rosen gave that time, which was vintage Neal. And I say this mainly because to our oncology fellows now, I say, look right, look left, and there's going to be some really interesting people that you're meeting right now. Just remember them several years down the line. You know? Nancy was no different in her presentation today than when she gave her presidential address. She had all the [AUDIO OUT] and everything. And so, that was great. Nancy and I are the same age, but she's been my role model for 25 years. [AUDIO OUT] The other thing-- Well, a couple of other questions-- you've been on the board of both the AACR and ASCO. And I'm interested in what you see as both the contrasts and the mutual initiatives going forward and how they've evolved. Do you have any insights into that? Well, I think Saul Rosenberg may have said something about this [INAUDIBLE] to you. He always, from early on, lamented that, quotes, "commercialization" of ASCO, as opposed to its academic thing. I think, number one, ASCO has done a fantastic job in terms of medical education at many different levels. So I think that's a major success. I think also what clearly is needed now is that we get more of the real world experience. So if patients are treated with checkpoint inhibitors with lung cancer, we don't need to know the results of 300, or 400 patients, or 500. We need to know what happens in 10,000 or 20,000 patients. And the only way we're going to get this is to have some kind of interaction with everything that's going on in the real world. And I think ASCO is positioned to do that. And so, I see that type of interaction being very important. Back when I was on the board, there was-- well, how many people from the private sector should be on the board? And we need to have them have a voice, and all of this. And there was kind of the-- then some people in the private sector trying to take control of ASCO for their own group practices. And we won't go into any names or anything here. But I think what's eventually come out is the possibility to really be the best for everything, both educational, translation of findings. So if there's real improvement in discoveries which have happened to be made, we obviously want to get them out as quickly as possible. Patients demand it. But then also, that we can work out some way to get feedback. Actually, this is one of the reasons-- you've hit on a couple of big initiativies over the last 10 years that I've been involved with. One is the development of CancerLinQ. And we hope that CancerLinQ will provide exactly the kind of data you just asked for. The other is the establishment of the Department of Clinical Affairs, and reaching out to the state-affiliated councils. Steve Grubbs is our Vice-President for that. And it's made a big difference. So that instead of being us versus them, academic versus private practice, it's us versus cancer all together. I'm glad you noticed that, actually. One final question, and this is a bit of a trite question. But I'm asking each of my guests on the show, what do you consider your legacy, your greatest accomplishment? In the end, what are people going to remember John Minna has done to change the face of oncology? Is it your science, or your mentoring? Or what's the one thing you would put your finger on? Well, I think Bob Young and I have an agreement about this. It's the mentoring and everything. And I think training the next generation, setting the example, is very important. I would say one other thing that's really important about ASCO that I see going forward is integrating surgery, radiotherapy, other disciplines, too. And I think it's been very successful. It wasn't necessarily all that way at first. But it's been really key. And getting a chance to know some of the giants in surgery and giants in radiation oncology, like Sam Hellman and Eli Glatstein. And I think Vince, in his book, in many ways saw that, too. The DeVita textbook with Hellman and Steve Rosenberg was an important example of that. So I think that's another important legacy from ASCO too. I agree. Well, actually, I think we've run out of time. Dr. Minna, I can't tell you how much I appreciate your taking the time to speak with us today. I'm sure the memberships can be thrilled to listen to the stories you've told. It's interesting, you've referred to several people I've actually already interviewed, or have planned to interview in the near future. You dropped a lot of names. And that's because-- and you sort of alluded to this. I'm not sure any of us recognize where we are in history at the time that history is being made. And then you look back and say, wow, I was there. And that you were fortunate to be at the NIH in those days. I was fortunate to be at the Dana-Farber in a few years after that. And you shed a lot of light. It's been terrific. Any final comments or parting words? Well, no. I think the one thing I would say is I was thinking back to those early ASCO meetings where there would be 5,000, 7,000, 8,000. So you couldn't even walk from one place to another, because you were always stopping and talking. And now you go to 15,000, 17,000 more. And I remember John Niederhuber and I, when he was director of the NCI, on the third day of ASCO walks through and he grabbed me, and he said, John, you're the first person I recognize. And I [INAUDIBLE]. We had roughly 40,000 people at the meeting this year. Yeah. I think that the question-- so going forward is how we need this family, but how do we get it so it could also be on the personal level? Anyway, Dan, it's been good talking to you. And we thank you for your service, Dan. Thank you. It's been great. For more original research, editorials, and review articles, please visit us online at JCO.org. This production is copyrighted to the American Society of Clinical Oncology. Thank you for listening. [MUSIC PLAYING]

Sid, Dave and Mike with MN United co-owner Dr Bill McGuire and Gopher fooball coach PJ Fleck

In this hour: Gopher basketball coach Richard Pitino, MN United CEO Dr. Bill McGuire, Gopher football P.J. Fleck, and Gopher baseball coach John Anderson.

Almost five years after he watched his first professional soccer match, Dr. Bill McGuire is finishing his first season as managing partner of Minnesota United FC in MLS. Dr. McGuire joins Wes in the studio to talk about that time. He reflects back on the decisions that led them to MLS and assesses the team's debut in the top league.

Melvyn Bragg and guests discuss the formation of volcanoes. In 79AD Mount Vesuvius erupted on the Bay of Naples, buried Pompeii in ash and drowned nearby Herculaneum in lava. The great letter writer Pliny the Younger was staying with his uncle in Misenum and was a witness to the cataclysm. He described it to the historian Tacitus, It seemed as though the sea was being sucked backwards, as if it were being pushed back by the shaking of the land. Certainly the shoreline moved outwards, and many sea creatures were left on dry sand. Behind us were frightening dark clouds, rent by lightning twisted and hurled, opening to reveal huge figures of flame. These were like lightning but bigger. This eruption, which claimed the life of Pliny's uncle, is one of about 500 volcanoes to have erupted in the last two thousand years, some of which are now categorised by vulcanologists as Plinian, after Pliny's famous description.What causes volcanoes? What role do they play in the formation and maintenance of our planet? And is it ever possible to predict when and where they are about to erupt?With Hilary Downes, Professor of Geochemistry at Birkbeck, University of London; Steve Self, Professor of Vulcanology at the Open University; Bill McGuire, Benfield Professor of Geophysical Hazards at University College London.

Melvyn Bragg and guests discuss the formation of volcanoes. In 79AD Mount Vesuvius erupted on the Bay of Naples, buried Pompeii in ash and drowned nearby Herculaneum in lava. The great letter writer Pliny the Younger was staying with his uncle in Misenum and was a witness to the cataclysm. He described it to the historian Tacitus, It seemed as though the sea was being sucked backwards, as if it were being pushed back by the shaking of the land. Certainly the shoreline moved outwards, and many sea creatures were left on dry sand. Behind us were frightening dark clouds, rent by lightning twisted and hurled, opening to reveal huge figures of flame. These were like lightning but bigger. This eruption, which claimed the life of Pliny's uncle, is one of about 500 volcanoes to have erupted in the last two thousand years, some of which are now categorised by vulcanologists as Plinian, after Pliny's famous description.What causes volcanoes? What role do they play in the formation and maintenance of our planet? And is it ever possible to predict when and where they are about to erupt?With Hilary Downes, Professor of Geochemistry at Birkbeck, University of London; Steve Self, Professor of Vulcanology at the Open University; Bill McGuire, Benfield Professor of Geophysical Hazards at University College London.

In 2004, three suitcases were discovered by different people in the Chesapeake Bay in Virginia, and they all contained the dismembered remains of an unknown person. But when police released a composite sketch of the victim, someone came forward believing it to be an old friend from New Jersey. As police began to question his family, co-workers, and friends, one person in particular stood out as a clear suspect, and suspicions against them just kept coming in. This is the story of Bill McGuire, also known as Suitcase Murder. *BONUS EPISODES* patreon.com/goingwestpodcast *CASE SOURCES* https://www.nytimes.com/2004/06/10/nyregion/light-is-shed-on-victim-but-no-clues-in-murder.html https://caselaw.findlaw.com/nj-superior-court-appellate-division/1559582.html https://www.findagrave.com/memorial/72310107/william-theodore-mcguire https://en.wikipedia.org/wiki/Melanie_McGuire https://www.dailypress.com/news/dp-xpm-20040609-2004-06-09-0406090098-story.html https://abcnews.go.com/Primetime/story?id=3301941&page=1 https://thecinemaholic.com/where-is-melanie-mcguires-family-now/ https://www.cbsnews.com/news/the-mcguire-diaries/ https://www.nytimes.com/2004/06/10/nyregion/light-is-shed-on-victim-but-no-clues-in-murder.html https://archive.centraljersey.com/2007/03/28/mcguires-lover-tells-jury-of-their-affair/ https://www.nj.com/ledgerupdates/2007/03/mcguire_murder_trial_continues_1.html https://archive.centraljersey.com/2007/04/18/defense-defendant-did-not-conduct-internet-searches/ https://murderpedia.org/female.M/m/mcguire-melanie-evidence.htm https://murderpedia.org/female.M/m/mcguire-melanie.htm https://www.nj.com/ledgerarchives/2007/07/mcguire_timeline.html Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy