Podcasts about medical biophysics

How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life's experiences. In this episode, Dr Camidge sat down with Alexandra Rink, PhD, a medical physicist at Princess Margaret Cancer Centre; a clinician scientist at the Princess Margaret Research Institute; and an associate professor in the Departments of Radiation Oncology and Medical Biophysics at the University of Toronto in Canada. Drs Camidge and Rink discussed how Dr Rink's early career interest in forensics led her down the path toward becoming a medical physicist, how physics factor into radiation therapy delivery, and the importance of multidisciplinary collaboration to deliver optimal patient care.

Peter A. Levine, Ph.D. is the originator and developer of Somatic Experiencing® and the Director of Somatic Experiencing® International.Dr. Levine holds doctorate degrees in Medical Biophysics and in Psychology, and during his thirty five-year study of stress and trauma, has contributed to a variety of scientific and popular publications.Among his many accomplishments, Dr. Levine has received Lifetime Achievement awards from Psychotherapy Networker, the US Association for Body-Oriented Psychotherapy, and the Association for Training on Trauma and Attachment in Children. He served as a Stress consultant for NASA in the early space shuttle development. He served on the American Psychological Association task force for responding to the trauma of large-scale disasters and ethnopolitical warfare.He is currently a Senior Fellow and consultant at The Meadows Addiction and Trauma Treatment Center in Wickenburg, Arizona, and continues to teach trauma healing workshops internationally.In This EpisodePeter's Instagramhttps://www.somaticexperiencing.com/https://traumahealing.org/---If you'd like to support The Trauma Therapist Podcast and the work I do  you can do that here with a monthly donation of $5, $7, or $10: Donate to The Trauma Therapist PodcastClick here to join my email list and receive podcast updates and other news.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-trauma-therapist--5739761/support.

Peter A. Levine, Ph.D. is the originator and developer of Somatic Experiencing® and the Director of Somatic Experiencing® International.Dr. Levine holds doctorate degrees in Medical Biophysics and in Psychology, and during his thirty five-year study of stress and trauma, has contributed to a variety of scientific and popular publications.Among his many accomplishments, Dr. Levine has received Lifetime Achievement awards from Psychotherapy Networker, the US Association for Body-Oriented Psychotherapy, and the Association for Training on Trauma and Attachment in Children. He served as a Stress consultant for NASA in the early space shuttle development. He served on the American Psychological Association task force for responding to the trauma of large-scale disasters and ethnopolitical warfare.He is currently a Senior Fellow and consultant at The Meadows Addiction and Trauma Treatment Center in Wickenburg, Arizona, and continues to teach trauma healing workshops internationally.In This EpisodePeter's Instagramhttps://www.somaticexperiencing.com/https://traumahealing.org/---If you'd like to support The Trauma Therapist Podcast and the work I do  you can do that here with a monthly donation of $5, $7, or $10: Donate to The Trauma Therapist PodcastClick here to join my email list and receive podcast updates and other news.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-trauma-therapist--5739761/support.

Bring joy back to meal time! Sarah Ballantyne, PhD, shares the radical new science for getting the nutrients that your body needs from the food that you eat. It's that simple! Refreshing, compelling, and guilt free, Dr. Ballantyne's science-backed message focuses on the power of fully enjoying a wide variety of nutrient-dense foods to fuel vitality.  Earning a PhD in Medical Biophysics at age 26, this spunky scientist has the gift of storytelling and simplifying difficult information. You will love this episode!Visit my website DrDebbieOzment.com for valuable free downloads. Additionally, you will find shopping links which I have curated on the website. Please follow me on instagram at drdebbieozment.

Synopsis: In a recent episode of Biotech2050, hosted by Alok Tayi, Kristen Fortney, CEO of BioAge, provides valuable insights into the evolving landscape of aging biology and the innovative approach BioAge is taking to identify therapeutic targets. Kristen's background in aging biology, genetics, and statistics underscores her expertise in the field. The conversation delves into the shift towards translational research in aging biology, emphasizing the increasing interest in targeting aging-related diseases such as heart disease, Alzheimer's, and cancer. Kristen highlights the importance of leveraging human data, utilizing relevant animal models, and strategically allocating resources to enhance the success rate of drug development in the biotech industry. She shares BioAge's unique approach to drug discovery, focusing on human data sets collected over decades, and emphasizes the importance of identifying novel targets for aging-related diseases. This episode is essential listening for entrepreneurs in biotech and aging research, providing valuable insights into the current state and future prospects of the field, and highlighting the potential for driving innovation through collaboration and strategic partnerships. Biography: Kristen leads BioAge in its mission to develop a broad pipeline of therapies that target metabolic aging by harnessing the science of human longevity.Kristen draws from a deep background in geroscience and systems biology to advance BioAge's data-driven approach to identifying and targeting the molecular pathways that drive aging. Kristen received her PhD in Medical Biophysics from the University of Toronto, followed by postdoctoral training at Stanford University where she was a fellow of the Ellison Medical Foundation / American Federation for Aging Research. She has over 15 years of experience developing novel bioinformatics approaches for data-driven investigation into the mechanisms of aging and age-related disease, with 18 published papers spanning computational drug discovery, biomarkers of aging, and the genetics of exceptional human longevity. BioAge recently closed a Series D financing bringing the company's total raise above $300 million.

 In this special Resident Review episode of the PRS Global Open Keynotes Podcast, Dr. Blake Murphy discusses the role of augmented reality in plastic surgery education. This episode discusses the following PRS Global Open article: The Role of Augmented Reality in the Next Phase of Surgical Education by Mark S. Shafarenko, Joseph Catapano, Stefan O. P. Hofer and Blake D. Murphy. Read the article for free on PRSGlobalOpen.com: https://bit.ly/ARinPlasticSurgery Dr. Blake Murphy is an Assistant Professor and Plastic Surgeon within the Division of Plastic, Reconstructive & Aesthetic Surgery at the University of Toronto. He completed his PhD in Medical Biophysics, and fellowships in craniofacial surgery and reconstructive microsurgery. This “PRS Global Open Keynotes Podcast Resident Ambassador Special Edition” is hosted by 2023 PRS Global Open Resident Ambassadors: Dr. Kevin Kinuthia #PRSGlobalOpen #KeynotesPodcast #PlasticSurgery

This week, hosts Amalie Hutchinson and Charan Mandur interview our very own SOGS VP Academic, Kevin Moore. In addition to his role on the Society of Graduate Students advocating for and making grad student's voices heard, Kevin is a PhD Candidate in the department of Medical Biophysics where he studies blood flow. We chat about what his lab days look like, learn a bit more about how blood flows through our veins, hear about the best part about Kevin's grad experience: friendships made along the way. How very heart (..and the blood flowing through it..) warming. Recorded on October 4, 2022. Produced by Amalie Hutchinson. Theme song provided by https://freebeats.io/ Produced by White Hot.

From SAND 18 with Peter Levine, the father of trauma therapy work, and Thomas Huebl, a spiritual teacher known for his work integrating healing of collective trauma, discussing the relationship between healing trauma and spiritual growth. One theme that repeats throughout the discussion is that we are all connected through the traumatization of the world and that the healing of trauma is a way of returning to the wholeness and fullness of living. This talk was hosted by SAND co-founder Zaya Benazzo. In the episode they discuss Bliss states Holding lightness and darkness Nonduality of existence State and process awareness Meeting Albert Einstein Waves of Trauma healing Free Will Collective Trauma Processing Apologies for a few audio issues with this live recording. Hopefully, you can listen past that to the content of what they are offering! And you'll hear there's QA from the audience at the end. Peter Levine, Ph. D. is the founder and pioneer of Somatic Experiencing® (SE®)and has made it his life-time's work to continue developing it. He holds doctorates in both Medical Biophysics and Psychology. Peter's work led him to become a stress consultant for NASA during the development of the Space Shuttle. somaticexperiencing.com Thomas Hübl is a contemporary mystic, international spiritual teacher, and author of Healing Collective Trauma: A Process for Integrating Our Intergenerational and Cultural Wounds (2020), whose work seeks to integrate the core insights of the great wisdom traditions with the discoveries of modern science. thomashuebl.com And Zaya Benazzo is a filmmaker, producer, activist, and co-founder of SAND. Science and Nonduality is a community inspired by timeless wisdom, informed by cutting-edge science, and grounded in direct experience. We come together in an open-hearted exploration while celebrating our humanity. scienceandnonduality.com

Dr. Sarah Ballantyne is a New York Times bestselling author and creator of the award-winning website, The Paleo Mom. She joins JJ in today's podcast episode to explore the ketogenic diet and talk about the best options for healthy weight loss. Listen as Dr. Ballantyne explains the pros and cons of the ketogenic diet, including how it can negatively impact everything from your thyroid and sex hormones to your metabolism and bone health. Dr. Ballantyne also shares her top tips for losing weight, with scientific studies to back up each one. Dr. Ballantyne has a Ph.D. in Medical Biophysics and has lost 120 pounds herself – she's here to share her wealth of knowledge and inspiration with us all! Get Dr. Sarah Ballantyne's free Paleo Quick Start Guide and Autoimmune Protocol Quick Start Guide https://www.thepaleomom.com/free-gift/

Functional MRI is a profoundly successful and powerful technique that so many of us use. It's still developing and adding to our insight about the human brain. While MRI was developed in the late 1970's and early 80's, it would be another decade before it was realized that MRI could be used to detect and map, non-invasively, human brain activation. My guests today, Ken Kwong, Bob Turner, and Ravi Menon were the first who showed this capability. Ken's successful experiment in early May of 1991 was arguably the first. Ravi, who was the key player in the Minnesota group, had produced solid fMRI results by the summer of 1991, and I had my first successful experiment in Sept of 1991. Bob Turner was a key player in his physiologic manipulation experiments in Cats. He collaborated with Ken, and also showed results of his own at 4T shortly after as well. We were all there at the Society for Magnetic Resonance Imaging Meeting in San Francisco in August of 1991 when Tom Brady (who headed MGH NMR Center at the time), first showed in his plenary lecture, the crude but stunning jaw dropping brain activation movies. The moment I saw that, I knew what I wanted to do for the rest of my career. We have them all here to reflect on those heady days, what led up to their findings, and the bright future of fMRI. Guests: Ken Kwong has been conducting MRI research at the Mass General Hospital since the late 80's when he pioneered diffusion imaging, as well as perfusion imaging approaches. He's currently associate professor at the MGH Martinos Center. Robert Turner trained with inventor of Echo Planar Imaging, Peter Mansfield, among others, and while working at the NIH, performed those first critical experiments, demonstrating BOLD contrast as well as obtaining some of the first results in humans at 4T using his home built gradient coil. One of Bob's major contributions to the field was his early work in gradient coil design - which remains fundamental to what we do. From 2006 to 2014 he was the Director of the Department of Neurophysics at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig and is currently retired and living in Cambridge, England. Ravi Menon was a post doc at Minnesota and a driving force in the effort to produce functional images using a highly challenging non-EPI approach at 4T. He has been a steady contributor to fMRI methods ever since and is currently a Robarts Scientist and Canada Research Chair in Functional Magnetic Resonance Imaging, Co-Scientific Director of BrainsCAN which is Canada First Research Excellence Fund, Scientific Director, Centre for Functional and Metabolic Mapping, and Professor of Medical Biophysics, Medical Imaging & Psychiatry at The University of Western Ontario

The current pandemic has led to explosive investments in future of health technologies, primarily through venture capital channels. This is the first episode of the TechLink Wealth series discussing various thesis in the realm of venture capital and alternative investment strategies. The episode covers topics ranging from health as a foundation to a nation's wealth to differences in Eastern and Western philosophies to ways of getting involved in private sector investments. This episode's guest is Joseph Mocanu, a healthtech investor currently serving as a Managing Director of Verge HealthTech Fund and Verge Capital Management as well as a Non-Executive Director and Advisory Board Member to a variety of startups. In his work, he invests in ​​ technology-led solutions that enable prevention, health system efficiency, or definitive cures, with a particular focus on Asian markets. Joseph has a Ph.D. in Medical Biophysics from the University of Toronto, an MBA focused on health sector entrepreneurship from the Ivey School of Business at Western University, and a Molecular Genetics and Molecular Biology focused degree from the University of Toronto. To note, the information, statements, comments, views, and opinions expressed in this podcast do not constitute and should not be construed as an offer to buy or sell any securities or to make or consider any investment or course of action. For more details visit TechLink Health @ https://www.techlink.health or connect with Verge HealthTech Fund @ https://vergehc.com. This episode was hosted by Justine Reiss. If you're a healthcare practitioner or thought leader and interested in leveraging the TechLink Health platform for telehealth, e-consults, or advisory services, feel free to connect with us by visiting our site or downloading the TechLink Health app. iOS - https://apps.apple.com/app/techlink-health/id1492325493 Google Play - https://play.google.com/store/apps/details?id=millennialtech.techlinkhealth

In this episode we're going to learn about cancer radiotherapy, the use of radiation to treat cancer. So many people are afraid that nuclear radiation causes cancer, and yes this is possible if you receive a sudden megadose of radiation, but it is very difficult to get enough just enough radiation to increase the risk of cancer while not getting too much dose and dying from acute radiation sickness.  In the real world, radiation is used to kill cancer cells and save lives. I'm going to interview one of the world experts in this field of medicine. Dr. Blake Walters received an M.Sc. in Medical Biophysics at the University of Toronto in 1992. He joined the Ionizing Radiation Standards Group at the National Research Council of Canada in 1994. He received a PhD in Medical Physics from Maastricht University, The Netherlands, in 2017. With the NRC, Blake helped to develop new computational techniques to greatly improve the accuracy of cancer radiotherapy. This work helps to spare healthy tissue while maximizing the dose to the tumour. This work has been adopted in radiotherapy clinics around the world, and has become the gold standard for accurate radiotherapy planning. Currently, he continues his work for the NRCC, developing and implementing Monte Carlo techniques to meet the increasingly complex demands of current radiotherapy technologies.  He is also the in-house physicist, specializing in dose calculations for low energy X-rays, for a company that designs and manufactures pre-clinical and clinical irradiators sold around the world. Come check out The Rational View on YouTube! Join our Facebook discussion group Twitter @AlScottRational Instagram @The_Rational_View #TheRationalView #radiationtherapy #cancer #linearnothreshold #nuclear #radiation #health

On this week's episode of Race to Academia, we interview Dr. Tamara Walker who is an associate professor in the History Department at the University of Toronto. Her research interests are on slavery and racial formation in Latin America and how slaveries legacy still has a lasting impact today. Sun Eui Choi will tell us about her research in our student highlight. Sun Eui is a first year Master's student in the Department of Medical Biophysics at the University of Toronto. She is looking at neurological changes in pediatric acute lymphoblastic leukemia.

Welcome back to the TRANPHONX podcast, where I interview various experts on their various topics. In today's episode, I talk to a former classmate of mine in Theoretical Physics courses, Samal Munidasa. Samal is currently pursuing his Ph.D. in Medical Biophysics, and today we talk about various topics such as his research in MRI Lung Damage detection, coronavirus, his fascination with biology and physics, its relationship with life and consciousness, animal rights, free will and determinism, and much more. 0:00 Introduction : Ph.D. Medical Biophysics and MRI Lung Damage Detection Using Hyperpolarized Gas 6:32 Coronavirus Damage Detection, An MRI Analysis on Covid-19 Symptoms 8:55 Future Research and Thoughts of The Future in Medical Biophysics 12:12 Biology VS Physics, Biophysics As The Best of Both Worlds 15:20 Animals, Biology, Humans, Where Do We Fit In? 17:20 Animal Rights, Vegetarianism, Consciousness and Global Warming 26:30 The Solution to Our Problems: Alternative Food Sources, Morals, and Nature 30:40 Consciousness & Self Awareness, Where Do We Draw The Line? 34:27 Determinism & Free Will -- Fate, Destiny, or Randomness? 45:55 The Universal Simulation -- Are We Simulated, Are We Alone In The Universe? 52:20 Animals, the Nature of the Food Chain, the Right to Survival? 59:10 Outro

Welcome back to episode 437 of the Whole View. (0:27) Stacy welcomes new listeners and takes a quick moment to introduce herself. Stacy had a 20-year career in Federal Regulation and Law. She jokes about how she tries not to talk about it because it's such a boring topic. Discovering how what she put in and her body affected her health was a life-changing experience for her. Now she works as her own boss. Stacy leads a large team (mostly women) focused on getting safer, non-toxic products into consumers' hands. She also does weekly podcasts with her co-host, Dr. Sarah Ballantyne. Sarah also introduces herself to any new listeners. She has a medical research background and a Ph.D. in Medical Biophysics. Sarah also had a similar translational type experience as Stacy. While navigating her academic research career and struggling with over a dozen different health conditions, Sarah discovered just how much the food we eat impacts the way our bodies work. Looking at her lifestyle choices and their impact on her life opened a new pathway for her. Now Sarah is an author, blogger, health educator, and thinks of herself as a "science translator." Her goal is to dig deep into the literature and act as a bridge to the academic research community she used to bring that information to everyday people who can benefit from it. The Mission Of Nutrivore Stacy tells listeners that one of the best things they've done to help bridge that gap looks at the specific nutrients within different forms of food and how they affect our bodies. She adds that they've gotten so deep in the weeds, they want to look more big picture as to what being a "nutrivore" means from a whole health perspective. Stacy also hopes that doing this will provide more context for the science of past and future shows. Sarah tells the audience that she and Stacy have been throwing the word "nutrivore" around a lot lately. She thinks that it would be helpful to ground ourselves in understanding what the ultimate goal is. That means getting away from diet jargon. Sarah also shares that this is a fantastic episode to share with friends and family overwhelmed with diets. There are so many "fad diets" approaches out there that can be next to impossible to separate out what is an influencer making commissions off of selling a supplement line versus something rooted in science that may be misinterpreted. Sarah and Stacy try to stay as close to science as they possibly can. They use science to guide recommended health principles. The vast majority of scientific studies tell us that focusing on a nutrient-rich fuel source, as well as other lifestyle factors, are the things that support health. Diets vs. Health and Wellness Stacy shares a huge mental shift of focusing on the outcome being health helped her navigate. (6:18) "Diet" is a word used to sell you a weight loss product that actually depletes your body of nutrients. Or it could be referring to how you eat. And so, instead of using a term used that way, it's easier for Stacy to think of nutrient-density as a way to achieve the ultimate goal: health. Stacy tells listeners that the justification for all the things we do are all around this idea of health and wellness. As so, as confusing as that is, one of the things that people get askew is the idea of nutrients. She attributes this to macro and micronutrients. And they are entirely different. Stacy suggests they start with the very basics and go over what they mean by "nutrient." She also reminds listeners that the goal of every one of these shows is never to cause shame or guilt, whether for past choices or future ones. Stacy adds one is perfect, and no one ever will be perfect. But we can make choices if we know what health looks like, and the more choices we make toward that goal, the better off we'll be. What Are Nutrients? Sarah dives into what the different nutrients are. (8:53) She explains that Macronutrients are protein, carbohydrates, and fats, and they amount to energy. So what they do is supply our body with the energy required for chemical reactions to occur.  Micronutrients are amino acids, fatty acids, vitamins, and vitamin-like compounds, minerals, and phytonutrients.  These are the building blocks for cellular structures and resources needed for all those chemical reactions to happen. Sarah explains that they're called "macro" and "micro" due to the amount of each that we need to consume. So we need larger amounts of energy to drive all these chemical reactions. And then we need smaller amounts of building blocks and resources. Sarah explains that our body breaks it down into individual amino acids when we digest a protein before it's absorbed. The protein itself is a macronutrient, while the amino acid is a micronutrient. However, the body needs both equally. Without either nutrient, our cells stop being able to do the things they need to do their jobs. Sarah believes it would be helpful to talk about a few examples of a biological system. And how it uses nutrients to sustain itself or drive its function in some way. When you understand that we use these nutrients are up in chemical reactions, it becomes a lot easier to see why we need to replenish them by consuming those nutrients constantly. Essential and Nonessential Stacy shares how it's been helpful for her to think about things in terms of essential and nonessential things. Sarah agrees, saying that the classification of essential and nonessential nutrients is very interesting. Anything labeled essential has two things in common: We know that our bodies can't make it at all or anywhere near enough of what we need, so we need to get it from outside sources There is an identified disease that occurs from deficiency of that nutrient Vitamin C and Iron are both classified as essential because Scurvy or Anemia comes from insufficient quantities. With nonessential nutrients, we can make them ourselves in a dire situation, or there's never been a deficiency-disease identified from not getting enough. Fiber would be an example of a nonessential nutrient. Sarah explains that this is a misnomer because we do actually need both to function properly. She adds that with nonessential, it means that you won't die without them. And that it's very different from saying you'll be healthy without them. What It All Means Stacy shares how mind-blowing it is to think about how her body and make something automatically when it needs to. Sarah talks a little bit about Vitamin A and how some people are genetically unable to make their own. And how this relates to how we need to think about consuming active forms of vitamins that we can get from food. Stacy agrees, sharing how we much rather get the nutrients her body needs from food, and not supplements, whenever she can. Sarah also takes a minute to emphasize there is a lot of science showing that nutrients in a multivitamin are very poorly absorbed. They tend to go straight through you, and part of that has to do without the nutrients are put into the tablet or capsules. Sarah explains the steps folic acid goes through as an example and what can impact our ability to absorb it into our bodies. She also reiterates that it's best to get as much as we can from our food because it's so much easier for us to get the nutrients we can use from there. How Are Nutrients Used in Our Body? Sarah wants to use this next example mostly just to show how complex these processes are. (23:22) There are about twelve biological systems, and they are things like the muscular and skeletal systems. Central Nervous System She will be talking about the central nervous system in this example. She also explains that the central nervous system controls much more than just your brain, but also your heart, lungs, etc. Biologically speaking, without your brain controlling your central nervous system, your body can't do anything. It turns out brains are really necessary for health! For example, B-vitamins are used by the mitochondria in our cells in the chemical reactions (together called the Kreb's cycle or citric acid cycle) to make the cellular energy molecule (called ATP) from sugars and fat we eat, as well as glycogen at fat we store. The nervous system (brain, spinal cord and nerves) needs: Vitamin B1: neurotransmitter production Vitamin B6:  neurotransmitter production Choline:  neurotransmitter production Vitamin B12: myelin sheath Copper:  myelin sheath B vitamins in general: ATP production / mitochondrial function Vitamin D: gene expression, biorhythms Calcium: nerve impulses Potassium: nerve impulses Sulfur: cell regeneration, oxygen use Omega-3 Fats: nerve signaling and cellular health, maintains blood-brain barrier Tryptophan:  serotonin, melatonin Phenylalanine: dopamine Glutamate, glutamic acid: GABA Polyphenols: promote neuronal signaling, increase production of antioxidant and anti-inflammatory agents Our brains are very unique because it has this special barrier. Not everything in the blood can get into the brain, which's different from other tissues. This barrier protects the brain from pathogens and toxins that might be in the blood, and without sufficient Omega-3 fats, we can't maintain that barrier's integrity. Sarah adds that this is a very generalized list of nutrients the central nervous system needs to function. Check out this study for more information on how dietary factors influence the central nervous system! The Immune System She adds that she often talks about the immune system as a "nutrient hog" because it's the most greedy system in terms of nutrients it requires to function optimally. When it's not working properly, it tends to turn on inflammation and not be able to turn it off. This is often called "systemic inflammation" and contributes to every chronic illness, such as autoimmune disease, cardiovascular disease, asthma, diabetes, kidney disease, etc. Sarah sums up that an immune system that cannot regulate itself is a very bad thing. The immune system needs: Vitamin A:  immune regulator, differentiation Vitamin D: immune regulator, Treg cells Vitamin E: antioxidant Vitamin K2: antioxidant Vitamin B12: cell production, methylation Vitamin C: antioxidant Zinc: T-cell development and activation, cytokines Selenium: antioxidant, cell function and activation Iodine: phagocyte health Iron: antioxidant enzymes Magnesium: thymus gland Copper: cytokine production, cell proliferation Flavonoids: antioxidants Omega 3 fats: phagocytes It turns out that nutrient insufficiencies (which is different from deficiencies because we're getting some, just not enough) pretty dramatically impact how the immune system is functioning. Sarah says that specifically Vitamins A and D are really important for immune regulation, which reigns in the system, so you don't get that system-wide inflammation. Our immune system also identifies cells that may be up to some cancer-like shenanigans and kill them off before becoming cancerous. So part of the process of cancer development is the immune system failing to identify those cells.   Deficiency vs. Insufficiency Sarah explains that just between these two systems, nearly every essential and nonessential nutrient is represented.   (33:55) Stacy takes a moment say how interesting she finds insufficiencies versus deficiencies. She adds that due to the high levels of deficiencies there are, the levels of insufficiencies much be way higher. Sarah defines insufficiencies as not consuming the recommended daily allowance of a specific nutrient. The "recommended" numbers are set based on a body of scientific literature for which 97.5% of the population will not show a deficiency. Sarah also explains that that recommended number should be seen as a minimus and not a goal. And there's still a percentage of the population that that won't be enough for. She defines a deficiency as, if doctors measured it in your blood, you wouldn't have the amount considered in the normal range, or you have some sort of symptom associated with not having enough of that nutrient. Sarah explains that deficiency in a single nutrient can impact the function of multiple biological systems. If a biological system is missing a nutrient required for optimal function, the body can not be optimally healthy. In fact, nutrient deficiencies are linked to every chronic illness! How Prevalent are Nutrient Deficiencies? Stacy asks about how prevalent nutrient deficiencies are. (39:10) Sarah explains that one of the main ways deficiencies are studied is through food journals. Scientists have people send in their meals, and they study them that way. The following chart includes food and supplements like multivitamins: Sarah repeats how each of the nutrients is important to every system of the body. They all use them. And when you're deficient in something, a system that needs it to function isn't functioning to its highest capacity. Sarah adds that when you take supplements out of the equation, these numbers get even worse: For example, the immune system not operating at full capacity can't heal a cut, fight off an illness, or even turn itself off as best as it should. Sarah also includes examples from the liver and brain not functioning optimally. She also explains that our genetics play a big role in how susceptible we are to nutritional deficiencies. And it's not always predictable how long our bodies can go "running on fumes." Top 10 Nutrients We’re Deficient In Stacy asks about which nutrients are the most common for deficiencies and where we might find a solution. (43:54) Sarah says that an estimated 90% of Americans are deficient in at least 1 essential nutrient! She also explains there are ten nutrients out there that over half of us are said to be deficient in. Vitamin A Sarah tells the audience that roughly 56% of us are diffident in Vitamin A and recaps how Vitamin A is very often found in animal food sources. Vitamin A is important for our bones, eyes, immune health, maintenance and normal regeneration of all our barriers (like the gut and blood-brain barriers), and more. Sarah drops that the top food source for gaining Vitamin A is the liver and pauses for dramatic effect. Stacy adds that organ meat is a high-optimized source for almost all of the deficiencies on this list. But before Sarah gets too deep into that, Stacy reminds listeners not to worry- you can take a pull for that. Stacy also wants listeners to understand that she and Sarah go so deep into where you can find all of these things in foods because taking a multivitamin isn't always as readily absorbed or as high in quality as something you can get from a food source. Stacy shares that she's not actively putting organ meat on her family's table, and so for her, the best way to get it is in supplement form. She adds that it is not an extraction; it is a whole food that is dehydrated and powdered. Sarah lists red meat, organ meat, pork, poultry, fish, and shellfish are all good sources of Vitamin A. Vegetable sources must be converted into an active form, which is very inefficient (as low as 3%). How It Effects Us Stacy adds it takes a few years for these deficiencies to catch up with us, and we won't notice how being deficient is affecting us right away. She recognizes that not everyone eats meat, and that's okay. Fish and eggs also get you very far if you're able to prioritize them. Stacy shares that in her youth, being a vegetarian did affect her health negatively long-term because she wasn't eating the correct kinds of foods to supplement what she wasn't getting from animal sources. Vitamin B6 Sarah explains that approximately 54% of us are deficient in Vitamin B6. (51:02) Vitamin B6 is essential for cellular energy, metabolism of amino acids and lipids, required for gluconeogenesis, synthesis of neurotransmitters, and hemoglobin, supporting the methylation cycle. Sarah takes a minute to explain to listeners how the methylation cycle works for turning proteins on and off. Peppers, onion family, pistachios, liver, fish, meat (poultry and red meat), sunflower seeds, garlic, and dark leafy greens are all great sources of Vitamin B6. Stacy asks about other forms of B Vitamins and if they're found in similar food sources. Sarah answers that it's a good general rule. Vitamin B9 Sarah tells the audience that 75% of us are deficient in this B Vitamin. She explains that it's essential to metabolize nucleic acids and amino acids, cell division, and production of red blood cells, supporting the methylation cycle. Food sources for B9 are organ meat, green veggies, leafy greens, legumes, beets, asparagus, avocados, papayas, strawberries, and seaweed. Vitamin D 75% of us are deficient in Vitamin D. Stacy tells viewers that the best source of vitamin D is from the sun! Sarah adds that where this vitamin comes from is due to our cholesterol's response to that UV radiation. Stacy and Sarah went further into detail in Episode 354! This nutrient controls the expression of over 200 genes. Vitamin D is critical for the function of mineral metabolism, bone mineralization and growth, biosynthesis of neurotrophic factors, hormone regulation, cell survival and division, circadian rhythms, barrier tissue health, and immune system health. Sarah tells the audience that it's very important to get their vitamin D levels tested. And if they're low, look at supplementation. The dose sufficient to bring you up to the level you need to be at varies wildly from person to person. And that is controlled by how your body regulates vitamin D and your environmental factors. Too Much Is A Thing? Sarah also explains that it's very hard to get enough from food on its own if you're already deficient. She also adds that there's a happy medium range and such a thing as too much Vitamin D. She does say it's usually cured by supplements and very hard to do with just food alone. Top food sources include fish, grass-fed dairy, oysters, pastured eggs, grass-fed meat, pasture-raised meat, shrimp, other shellfish, mushroom (D2), and tofu (D2). Stacy loves the idea of animals living a happy life outside in the sun and that the best animal products for our health come full circle. Sarah says this goes as far as plants grown in depleted soil as well. So how our food is raised is very important to our health as well. She also reminds listeners that eating snout to tail means nothing is going to waste. Vitamin E Sarah explains that around 60% of people are deficient in Vitamin E. She adds that it functions as an antioxidant throughout the body, which is quite important for immune function. It's also very important for anti-aging of cells. Top food sources for Vitamin E are nuts, seeds, leafy greens, avocado, olives, organ meat, shellfish, unrefined plant oil, fatty fish, and winter squash. Sarah also explains that high-fat plant products are the best producers of this vitamin. Calcium Approximately 65% of us are deficient in calcium. Both calcium and magnesium are electrolytes. Sarah explains that calcium is a large component of bones and teeth, is a cofactor for many enzymes, cell signaling (metabolism, cell division, gene expression), blood clotting, neurotransmitter release and nerve conductance, and muscle contraction. Sarah explains what being a cofactor is and how it works. Top food sources for calcium are grass-fed dairy, tofu, sesame seeds, chives, chia seeds, radishes, seaweed, beef, dark leafy greens, and sardines. Stacy points out that there's more than just dairy on the list. Sarah agrees and points out how the body more easily absorbs the calcium in dark leafy greens than the calcium in dairy. In fact, studies on dairy are pretty mixed in terms of osteoporosis. Stacy adds that stress is big for depleting calcium. Magnesium  Around 68% of people are magnesium deficient. Sarah and Stacy covered magnesium in detail in Episode 409! Sarah explains that three hundred different enzymes use magnesium. It's also key for ATP synthesis, DNA and RNA synthesis, a constituent of bones and teeth, neuromuscular contractions, production of testosterone and progesterone, metabolism of phosphorus, calcium, potassium, sodium, B vitamins, and vitamins C and E, cofactor in methylation, and the immune system. Top food sources for magnesium are seaweed, dark leafy greens, chives, pumpkin seeds, fish, soy, Brazil nuts, sunflower seeds, other nuts and seeds, and avocados. Sarah tells listeners that the "superstar" foods for this nutrient are leafy greens. She also explains that it's one of the harder nutrients to get adequate amounts of from food sources alone. Sarah explains why she loves food journals from the point of view of piecing together the puzzle of what we're getting, what we need, and where we need to get it from. Which is exactly the idea behind nutrivore! Zinc Around 73% of people are zinc deficient. Sarah tells the audience that zinc is everywhere and kind of a do-it-all nutrient. Sarah explains the diverse functions of zinc include the activity of approximately three hundred different enzymes, DNA and RNA transcription, regulates apoptosis, absorption and activity of B vitamins, muscle contraction, connective tissue formation, insulin production, and testosterone, a component of vitamin D receptor, and immune system. Stacy says that without looking, she can name the number one source of zinc: oysters! If they are in season and on the menu, she orders them. Sarah claims that you will have met your zinc quota for the week if you eat oysters once a week. Sarah adds liver, crab, wild game (red meat), loser, farmed red meat, clams, organ meat, mushrooms, and seaweed are all great food sources for zinc. She reiterates that so many of us are deficient and so much of our body relies on zinc, that there's never been a better reason to try organ meat and shellfish. DHA & EPA Around 70% of people are DHA & EPA deficient. These are also known as Omega fats. Sarah tells listeners DHA & EPA are used by the body for anti-inflammatory, immune health, vascular health, neural/brain health, vision health, fetal development, supports healthy microbiome, and cellular health in general. Fish, shellfish, grass-fed meat, organ meat, grass-fed dairy, and seaweed are great food sources for DHA and EPA. Sarah adds that nuts and seeds can be very high in ALA (especially flax, chia, walnuts), which can be converted into DHA and EPA. Although this is usually inefficiently done- again 3%. Fiber Stacy says you can never talk about fiber enough. In fact, if she's eating carbohydrates, she wants to be eating fiber as well. Sarah says about 90% of us are deficient in fiber! Sarah explains we need fiber because it feeds the gut microbiome, helps eliminate toxins, helps regulate hormones, regulates gut motility, fermentation produces SCFA, and promotes better sleep. Plus, it helps you poop! Sarah explains what happens in our intensities if we don't have enough fiber to bind our waste eliminated by the body. Some stuff we want to get rid of can actually be reabsorbed into the body if we don't have enough fiber to aid in getting rid of. Fruits, veggies, mushrooms, and legumes are all great food sources of fiber. Sarah also reminds listeners that we want diversity in our fibers for the sake of our gut microbiome. Nutrivore: Frequent Flyer Nutrient-Dense Foods Sarah and Stacy have done several different shows on the importance of vegetables and vegetable diversity for any listeners interested in checking them out. (1:19:15) Stacy also recaps a previous show about needing 30 different types of fruits and veggies a week. And how it is not as scary as it sounds. Sarah shares that certain foods, like liver and other organ meat, vegetables, and seafood, come up repeatedly as the best sources of these nutrients. Stacy shares how mushrooms and seaweed were on several lists and found that very interesting. Sarah explains the term "nutrient density" refers to micronutrients' concentration (mainly vitamins and minerals) per calorie of food.  She also knows that organ meat is a "big ask" for people. There is a big market out there for encapsulating these foods, so don't run away! Sarah also explains that nutrient-dense foods supply a wide range of vitamins and minerals relative to the calories they contain.  Low nutrient density foods supply lots of energy without much in the way of additional nutrition.  Sarah tells listeners that a nutrivorous, or nutrient-sufficient, diet is practically achieved by consuming more nutrient-dense foods, in ratios that provide synergistic quantities of every nutrient. More Episodes: A nutrient-sufficient diet must focus on the most nutrient-dense foods available: Offal (how to eat nose to tail EP 347) Seafood (fish, shellfish, sea vegetables) (seafood safety concerns EP 366) Vegetables (8+ servings daily!!!!)  (most recent is 30 a week, EP 424) 373, 335, 304, 286, 152, plus a ton more, talk about different aspects of high veggie consumption, why, what counts, and what that looks like Edible fungi (EP 392, 307) Fruit (3-5 servings per day) (Case for more carbs, 305) Other nutrient-dense foods: High-quality meat and dairy (Ep 317 Budget vs Quality) Healthy fats (EVOO EP 326) (Best fats for gut health EP 414) Nuts and seeds (EP 413) Herbs and spices Fermented foods (EP 155) Eggs Properly-prepared legumes Sarah tells the audience that she recognizes that we are all human and that change is hard. She wants to be sure to permit listeners not to have to go "all-in" immediately if that's not the best way for you to make a long-lasting, positive change in your life. Sarah also reminds listeners to aim for 30 different fruits and veggies a week! Nutrivore: The Whole Diet Stacy loves the idea of taking this all into account when looking at a nutrivore diet. This is because the focus is on eating what we need to feel like our best selves. A nutrivorous diet is one in which the goal is to fully meet the body’s physiologic needs for both essential and nonessential nutrients from the foods we eat.  This is also called a nutrient-sufficient diet. Stacy tells listeners that a nutrivore diet is about the overall quality of the whole diet. And not about a list of yes-foods and no-foods.   Stacy shared that, as a person with many food intolerances, she learned the hard way that if you continue to eat a food your body is intolerant to, you're keeping your body from absorbing more of everything else. That means you then need to consume more of everything because your body still hasn't absorbed everything it needs to function because something like gluten or nightshades are gumming up the works. Be Nice To Yourself Sarah explains that though eliminating empty calorie foods helps to achieve nutrient sufficiency, no food is strictly forbidden. There are no "yes" food and "no" foods. You can "buy" yourself wiggle room with your favorite "junk foods" by eating more nutrient-dense superfoods. Also, food sensitivities and other dietary priorities can be layered on top of this approach. Sarah suggests thinking of nutrivore as a diet modifier: you can do nutrivore Mediterranean, nutrivore vegetarian, nutrivore Paleo, etc. Don't Be Afraid Of Going Nutrivore! Stacy shares that her body had been able to handle more stress in life because her body is less involved with dealing with inflammatory foods. (1:37:14) Sarah shares that this might be a great time to emphasize that it only takes a few weeks for our taste buds to adapt to big shifts in our diets.  Studies looking at taste adaptation to one of a low-sugar, low-salt, or low-fat diet have shown that participants develop a preference for the healthier foods they've been eating over a few weeks.  This is attributable to our taste buds becoming more sensitive.  Sarah explains that familiarity and flavor association with positive experiences is another key driver of food preference.  Studies show that with repeated exposure to foods that we innately dislike, we can lose our aversions to those foods and actually develop a preference for them.  In fact, we can learn to like new flavors after trying them as few as four or five times.  What does this mean? If you aren't enjoying the new healthy foods you're adding to your diet, don't give up. The more of these healthy foods you eat, the more you'll enjoy them! Final Thoughts on Nutrivore Stacy shares that her favorite thing she used to tell her kids is your tongue sheds tastebuds like a snake sheds its skin. And you just have to wait until the next round to see if you like whatever it is then. Stacy also said it's not so much as figuring out to like a certain food but finding a way to prepare. She invites listeners to stay open-minded, ready, and willing to get there. Thanks so much for listening!

Dr. Peter Levine with Micheál O'Mathúna on Covid19, Fear, Trauma, Resilience, Presence + Shamanism   Find out more below... This interview was conducted by Micheál O'Mathúna who is a Journalist, Author, Filmmaker, Media Relations Consultant and Radio Show presenter. He also conducts one-to-one coaching, group coaching and delivers transformative workshops in various areas of health and wellbeing. He is also the founder of The Health Zone, which an inspiring, motivational and educational platform to empower people to be healthier, happier, more authentic and realise their true potential in their lives. You can find out more about Micheál O'Mathúna and The Health Zone here. You listen to every episode of The Health Zone here ------> http://www.thehealthzones.com/ Follow us on Instagram here ---> https://www.instagram.com/dhealthzone/ Follow us on Facebook here ----> https://www.facebook.com/thehealthzoneshow/ Follow us on Twitter here ---> https://twitter.com/dhealthzone Subscribe to our YouTube channel here ---> https://www.youtube.com/channel/UCkbZXDYJF_ypdjEmQk-BEIg ---> Join our Facebook Group here ---> https://www.facebook.com/groups/thehealthzone/ Peter tells us: ✓  How Fear is The Killer of The Mind ✓  The Importance of Opening Into The Fear ✓  How You Can Disassociate From Pain or Trauma in Your Body ✓  How Trauma Effects Whole Communities, Nations and The World ✓  How the Somatic Experiencing Method Can Promote Resilience During Covid19 ✓  How Emotional Pain Gets Stored In Your Body Cells  ✓  What You Can Learn From Shamanic Traditions in Healing Trauma ✓  How You Can Only Be Present For Another When You Are Present in Yourself    Dr Peter Levine, Ph.D. is the founder and pioneer of Somatic Experiencing® (SE®)and has made it his life-time's work to continue developing it. He holds doctorates in both Medical Biophysics and Psychology. Dr Peter A. Levine received his PhD in medical biophysics from the University of California in Berkeley and also holds a doctorate in psychology from International University. He has worked in the field of stress and trauma for over 40 years and is the developer of the Somatic Experiencing® method. Peter's original contribution to the field of Body-Psychotherapy was honoured in 2010 when he received the Lifetime Achievement award from the United States Association for Body Psychotherapy (USABP). That same year he also received the honorary Reis Davis Chair in Child Psychiatry for his innovative contribution to therapy for children and adolescents. Beginning in the 1970s, Peter's explorations into how animals deal with threat led to the development of the Somatic Experiencing method, a method that is highly effective in dealing with the effects of overwhelm on our nervous system, called Somatic Experiencing® (SE™). SE™ is a clinical methodology based upon an appreciation of why animals in the wild are not traumatized by routine threats to their lives, while humans, on the other hand, are readily overwhelmed and often subject to the traumatic symptoms of hyperarousal, shutdown and dysregulation. Dr Levine was a stress consultant for NASA on the development of the space shuttle project and was a member of the Institute of World Affairs Task Force of Psychologists for Social Responsibility in developing responses to large-scale disasters and ethnopolitical warfare. He is also a Senior Fellow at The Meadows Addiction and Trauma Treatment Center in Wickenburg, Arizona. Levine's international bestseller, Waking the Tiger: Healing Trauma, has been translated into twenty-two languages. His recent interests include the prevention of trauma in children, and he has co-written two books, with Maggie Kline, in this area: Trauma Through a Child's Eyes and Trauma-Proofing Your Kids. His most recent book: In an Unspoken Voice: How the Body Releases Trauma and Restores Goodness, was released to rave reviews.  https://somaticexperiencing.com/  

Paul FRASER, Jeno Diener Chair in Neurodegenerative Diseases, Tanz Centre and Department of Medical Biophysics, University of Toronto, CANADA speaks on "SUMOylation pathways in neuronal function and neurodegeneration". This movie has been recorded at ICGRB Trieste, Italy.

Karla Badger-Brown is the Director of ASPIRE, a Toronto Finance International program developed to grow the talent pool of work-ready talent for the financial services industry. Karla has experience working in financial services, life sciences, retail, healthcare, and sales. She has a Ph.D. in Medical Biophysics from the University of Toronto and a Bachelor of Science in Genetics from the University of Manitoba.   Karla joins me today to share how the ASPIRE program is changing the perspective of roles in the financial industry and helping students find opportunities to grow and expand their skills. She shares three core ways that ASPIRE helps students, including job matching, the ASPIRE Challenge, and free resources. Karla also reveals the details of the upcoming ASPIRE Edge program and shares tips for students to avoid common business etiquette mistakes.    “A lot of financial services organizations are moving far more toward being technology organizations that happen to work in finance.” - Karla Badger-Brown This Week on Young Money:   Changing the perspective of financial services companies The exciting and innovative roles in finance, from data scientists to graphic designers and psychologists How ASPIRE is helping students grow and expand their skills How the job matching platform at ASPIRE helps students find internships and co-ops The opportunities for students who take part in the ASPIRE Challenge  The ASPIRE resources to help students build business skills The upcoming ASPIRE Edge program Tips to help students avoid business etiquette mistakes  Why students should take full advantage of work opportunities   Key takeaways:   Take advantage of the ASPIRE opportunities ASPIRE is for students of any discipline Follow ASPIRE on social media for updates, employment and networking opportunities   Resources Mentioned:   EP050 The Canadian financial services sector revealed with Jennifer Reynolds, President & CEO of TFSA   Connect with Karla Badger-Brown:   ASPIRE Toronto Finance International Toronto Finance International on LinkedIn Toronto Finance International on Twitter Karla Badger-Brown on LinkedIn ASPIRE on LinkedIn ASPIRE on Facebook ASPIRE on Twitter ASPIRE on Instagram Get Your Young Money Questions ANSWERED!   Want to learn more about how you can stay financially fit? Leave a voice message to get all of your Young Money questions answered.    Remember - there is no silly question when it comes to your financial fitness.   Rate, Share & Inspire Other Young Millionaires-in-the-Making    Thanks for tuning into the Young Money Podcast - the advice show for young millionaires-in-the-making! If you enjoyed this week’s episode, head over to Apple Podcasts and leave us a rating and review. Visit our website to learn how easy it is to leave a review on Apple Podcasts.   Don’t forget to share your favorite episodes on social media!    Subscribe to the Young Money Podcast on iTunes so you never miss an episode and reach out to us on Facebook, Twitter, LinkedIn, our LinkedIn Company Page, or by visiting our website.

In this informative episode, we discuss why we have many discrepancies and issues between science and the public interpretation of science through modern social media while talking about applications of biotech in the modern world, especially pertaining to human health outcomes and improving agriculture. BIO: Kathleen Hefferon received her Ph.D. from the Department of Medical Biophysics, University of Toronto and completed her postdoctoral fellowship at Cornell University. Kathleen has published multiple research papers, chapters, and reviews, and has written three books. Kathleen is the Fulbright Canada Research Chair of Global Food Security and has been a visiting professor at the University of Toronto over the past year. Her research interests include virus expression vectors, food security agricultural biotechnology and global health. Kathleen lives in New York with her husband and two children. TIMESTAMPS: 0:15: Ketogeek mindset, updates, and product information 9:45: Dr. Kathleen’s story 11:46: Traveling abroad and her recent educational trip to Botswana 14:38: Issues with lack of women in livestock farming in Botswana 15:45: Traditional healing in Botswana 18:58: Potential applications of GMOs and drought-resistant plants in Africa 21:36: What challenges do you face when applying new technology in a developing country? 25:53: How did you end up engaging people on social media on scientific and controversial topics such as GMOs and glyphosate 38:04: Ambiguity in science and problems with establishing causality with certain chemicals 42:52: Why don’t many scientists engage with the public through social media and podcasting 50:49: What’s the biggest anti-GMO argument you hear? 55:50: Problem with science communication in the modern world 58:02: Kathleen’s research on using transgenic plants to produce vaccines 1:03:36: What are “plant virus nanoparticles”? 1:07:50: What are the potentials and limitations of transgenic derived vaccines? 1:10:31: Where did chemophobia originate from in the modern world? 1:18:33 Concerns with food wastage in developed and developing countries 1:21:50: Potential applications of GM crops for sequestering carbon and help with climate change 1:25:25: Given a billion dollars, what study would you do? 1:27:17: Final message and plugs GUEST LINKS: Twitter: https://twitter.com/KHefferon Research Gate: https://www.researchgate.net/profile/Kathleen_Hefferon Personal Link: https://micro.cornell.edu/people/kathleen-hefferon/ KETOGEEK LINKS: Shop Energy Pods Amazon: https://www.amazon.com/Ketogeek-Chocolate-Energy-Organic-Vanilla/dp/B07B88S36J Ketogeek Ghee on Amazon: https://www.amazon.com/dp/B07B29HM3D Ketogeek Merchandise, Ghee & Energy Pods: https://ketogeek.com/collections Ketogeek Newsletter: https://ketogeek.com/pages/sign-up Shop Energy Pods: https://ketogeek.com/collections/energy-pods Wholesale: https://ketogeek.com/pages/wholesale OTHER LINKS Bad Science by Ben Goldacre (Book & Affiliate Link)

Dr. Terry Peters is a Professor at Western University (London, ON, Canada) in Medical Biophysics. His research interests include image-guided surgery, virtual reality, and brain imaging. The blog post for this episode can be found at prof-talks.com.

Dr. Sarah Ballantyne is a New York Times bestselling author and creator of the award-winning website, The Paleo Mom. She joins JJ in today's podcast episode to explore the ketogenic diet and talk about the best options for healthy weight loss. Listen as Dr. Ballantyne explains the pros and cons of the ketogenic diet, including the impact it can have on your metabolism and hormonal health. Dr. Ballantyne also shares her top tips for losing weight and keeping it off, with scientific studies to back up each one. Dr. Ballantyne has a Ph.D in Medical Biophysics and has lost 120 pounds herself – she's here to share her wealth of knowledge and inspiration with us all!   Freebies From Today’s Episode Get Dr. Sarah Ballantyne’s free 15-Part Paleo ABC’s by going to JJVirgin.com/paleomom.   Main Points From Today’s Episode ** Need to revise The ketogenic diet has shown some real therapeutic benefits in patients with neurodegenerative and neurological diseases. However, there are some problems with a diet that's designed to mimic starvation when it comes to overall health. A recent study showed that 1 in 6 patients on a long-term keto diet for epilepsy developed hypothyroidism. Most of these patients became hypothyroid within the first month. Getting enough sleep is crucial to weight loss. Studies show that folks consume anywhere between 10 and 25 percent more calories the day after getting 6 hours of sleep compared to 8 hours.   Episode Play-By-Play [1:12] Dr. Sarah Ballantyne’s career briefing [3:50] What is the ketogenic diet?  [5:33] Uses of the ketogenic diet in patients with epilepsy [7:17] The ketogenic diet has shown some real therapeutic benefits in patients with neurodegenerative and neurological diseases. [7:52] There are some problems with a diet that's designed to mimic starvation when it comes to overall health. [9:06]  Busting the myth that you have to be in ketosis to burn fat. [11:23] The importance of metabolic flexibility [12:46] How a long-term ketogenic diet can lower your basal metabolic rate  [14:32] Common side effects of the ketogenic diet [17:09] The impact that the keto diet can have on thyroid health [18:27] The connection between your thyroid and other systems in your body [19:30] A recent study showed that 1 in 6 patients on a long-term keto diet for epilepsy developed hypothyroidism.   [21:34] The relationship between insulin and thyroid hormones [23:00] How the keto diet can affect female sex hormones [27:57] Dr. Ballantyne’s top recommendations for weight loss include a higher protein intake and plenty of veggies. [30:21] Studies show that exercise boosts weight loss success by helping with hormone regulation. [30:57] Getting enough sleep is crucial to weight loss. [33:15] Dr. Sarah Ballantyne’s free gift includes awesome ideas, resources, food lists, priorities, and cooking tips. [34:13] Starting your day off with the right breakfast sets your metabolic tone for the day. The perfect and easiest way to do this is with JJ’s All-In-One Paleo-Inspired Protein Shake! [35:33] Listener’s question: JJ, how many carbs should I eat? [37:00] The source of your carbs matters. [37:35] The Sugar Impact Diet helps you figure out the right amount and type of carbs for you.   Mentioned in this episode: Paleo-Inspired All-In-One Shake Sugar Impact Diet Jjvirgin.com JJ Virgin Official Facebook page JJ Virgin on Instagram JJ Virgin on YouTube

Inflammation, the gut, microbes, cortisol, and sore joints…what do these things have in common? Tune in to this week’s episode as we explore what it’s like living with an autoimmune condition. You’ll hear the perspectives of four individuals – Vanessa, Bonnie, Yohanna, and Megan – as they reflect on their journeys to receiving their diagnoses. They share their thoughts on navigating the Canadian Healthcare System and give advice for those newly diagnosed. You'll also hear from Dr. Kenneth Croitoru - gastroenterologist at Mount Sinai Hospital and Professor in the Department of Immunology at U of T – as well as Dr. Jayne Danska - Senior Scientist at The Hospital for Sick Children and Professor in Medical Biophysics and Immunology at U of T – who breakdown autoimmunity, debunk some common myths associated with autoimmune diseases, and discuss some of their exciting work in identifying factors causing susceptibility to Crohn’s and Type I Diabetes respectively. Until next time, #KeepItRaw!

Inflammation, the gut, microbes, cortisol, and sore joints…what do these things have in common? Tune in to this week’s episode as we explore what it’s like living with an autoimmune condition. You’ll hear the perspectives of four individuals – Vanessa, Bonnie, Yohanna, and Megan – as they reflect on their journeys to receiving their diagnoses. They share their thoughts on navigating the Canadian Healthcare System and give advice for those newly diagnosed. You'll also hear from Dr. Kenneth Croitoru - gastroenterologist at Mount Sinai Hospital and Professor in the Department of Immunology at U of T – as well as Dr. Jayne Danska - Senior Scientist at The Hospital for Sick Children and Professor in Medical Biophysics and Immunology at U of T – who breakdown autoimmunity, debunk some common myths associated with autoimmune diseases, and discuss some of their exciting work in identifying factors causing susceptibility to Crohn’s and Type I Diabetes respectively. Until next time, #KeepItRaw!

Former MBP graduate students return to the University of Toronto for an evening of networking and discussion. Listen to advice and unique perspectives in non-academic careers. ----Credits--- Organizers: Nina Wang and Deborah Ng (MBPCDA) Moderator: Danielle Croucher Panelists: Maude Tessier (Merck) Allison Aiken (Top Hat) Michelle Lenarduzzi (Optimus SBR) Ryan Doherty (iamsick.ca) Danielle Croucher (MBP PhD Candidate) Video and Audio Editing: Danielle Denisko (MBP Podcast) Ronald Wu (MBP Podcast) Brief overview of MBP Alumni by MBPGSA President Tonny Huang. Welcome address by MBP Chair Dr. Thomas Kislinger. The Alumni-Student networking reception was hosted by the Department of Medical Biophysics at The University of Toronto on June 13 2018.

http://www.alainguillot.com/john-robertson-the-value-of-simple/ Who is John Roberson? Dr. Robertson is a scientist, writer, investor, teacher, and an all-around nice guy. He specializes in explaining complex topics – scientific or financial – for regular people. He has a Ph.D. from the University of Western Ontario in Medical Biophysics, and he writes about personal finance in his blog Blessed by the Potato. Personal finance and investing have long been personal passions for John, and he has been an active part of the Canadian personal finance community for nearly a decade. In 2014 he published The Value of Simple to help investors move away from relying on commissioned sales staff to planning and investing on their own. The book focuses on helping people implement simple investment plans and get over behavioral pitfalls to success. He also has a course available to beginner do-it-yourself investors. Highlights from the interview Alain found out about John after listening to him in another podcast, Canadian Couch Potato #15. John started blogging about 20 years ago. Started to focus on personal finance after the 2008 financial crisis. When he was 18 years old, his dad helped him set up his first broker's account. John mentioned TD e-series as one of the less expensive Canadian Mutual Funds, but buyer be wear, if you contact a mutual fund representative, they might want to suggest a more expensive mutual fund. The way to find out how expensive is your mutual fund is to look at the MER (Management Expense Ratio). Managed Funds have an expense ratio of 2% to 3%. You want to avoid. You want to get mutual funds with expense ratios of less than 0.5%. Be careful buyers. This is not like a one time commission you pay when buying an object. This 2%-3% is taken out of your account EVERY YEAR. If you are expecting your mutual fund to have a return of 7%-8%, when you take out 2%-3%, that's almost 1/3 of your money going to the bank. If your investment horizon is 30-35 years, you are losing half of your investment value in fees. We spoke about diversifying investments out of Canada. Canada is only 2% of the global economy. In order to avoid home base bias, we should consider investing in the economies of other geographical sectors such as the U.S., Europe, Asia, etc. We suggested an equal split between Canada, U.S., and international index funds. We spoke about how to rebalance a portfolio. We spoke about stocks vs. bonds; how much to have of each. We spoke about setting up an account with Tangerine, with TD e-series and robot advisers. What's the difference between an ETF and a mutual fund? I have some money to invest. should I pay my mortgage or should I invest it in the market? Take away point: Fees matter but being invested and having a plan that can be followed matters just as more. John Robertson's recommendations Book: Stop Over-Thinking Your Money! by Preet Banerjee Blogs: Canadian Couch Pototato Podcast Because Money Mostly Money Moolala        

In the news this week, the launch of NeuroCDRD – a new initiative to accelerate development of treatments for neuro diseases; OICR researchers invent a new molecular barcode technology; and Aurinia Phramceuticals prices a US$150.5 million public offering of common shares. We have all this and more coming up on Biotechnology Focus Radio. Story 1 Our first story this week highlights Calgary, AB’s Oncolytics Biotech® Inc. The company has entered into a collaborative research project  with cancer charity Myeloma UK and multi-national biotech firm, Celgene.  In the joint initiative Myeloma UK has launched MUK eleven, a first-of-its-kind immunotherapy trial that aims to modulate the immune system to target myeloma. The Phase 1b trial will study Oncolytics immuno-viral therapy and lead product REOLYSIN®, in combination with Celgene Corporation's immunomodulatory drugs (IMiDs), Imnovid® (pomalidomide) or Revlimid® (lenalidomide), as a rescue treatment in relapsing myeloma patients. MUK eleven’s chief investigator Gordon Cook, Consultant Haematologist at Leeds Teaching Hospitals Trust  says this trial is about taking a new approach of activating a patient's own immune system to target their myeloma (immunotherapy) using a natural virus and lenalidomide or pomalidomide. REOLYSIN will be combined with Celgene's Imnovid® or Revlimid® in patients whose myeloma is progressing while on these IMiD treatments. The dose escalation trial will look at the safety and tolerability of these combinations, and will investigate whether the addition of REOLYSIN extends disease control in this patient group. This clinical study expands on earlier pre-clinical work by Professor Cook that demonstrated that REOLYSIN has dual modes of action against multiple myeloma; being both directly cytotoxic and also activating immune effector cells to target and destroy cancer cells. Further, this immune-mediated activity can be enhanced by immunomodulatory agents to eliminate disease. The trial will aim to recruit 44 patients across up to six Myeloma UK Clinical Trial Network centres in the UK. MUK eleven is part of the Myeloma UK Clinical Trial Network, a portfolio of early stage trials coordinated by the Clinical Trials Research Unit at the University of Leeds, focused on testing and speeding up access to promising new treatments for patients. Story 2 In a unique public-private partnership, Montreal’s Cyclenium Pharma Inc. and Toronto’s Hospital for Sick Children (SickKids) have entered into a research agreement designed to facilitate the discovery of novel modulators for multiple new and existing biological targets of pharmacological interest across a variety of disease areas, including cardiovascular, immunology and oncology.  Cylenium is a company focused on discovery and development of novel drug candidates through the use of its proprietary macrocyclic chemistry. The collaboration will give SickKids researchers immediate access to the company’s QUEST Library™ of next generation macrocyclic molecules and associated chemical hit and lead optimization capabilities. The initial objective of the partnership is to identify compounds capable of interacting with specific therapeutic targets being studied at SickKids, thereby providing tools to improve the understanding of their involvement in the pathophysiology of specific diseases, with the ultimate goal of discovering novel therapeutic or diagnostic agents. Cyclenium president, CSO and CEO Dr. Helmut Thomas.adds that his company’s library will be made available to researchers through the SickKids Proteomics, Analytics, Robotics & Chemical Biology Centre (SPARC BioCentre). The SPARC BioCentre is a high-throughput drug screening facility at SickKids. One of the first studies to be initiated involves targets implicated for the treatment of cancer and immune disorders. For Cyclenium, this is the latest in an extensive series of international discovery collaborations established with prominent companies and research institutions to explore the exciting potential of its unique macrocycle chemistry technology, including Astellas Pharma, Haplogen GmbH, Fundación MEDINA, German Cancer Research Center (DKFZ), McGill University/Goodman Cancer Research Centre, Institute for Research in Immunology and Cancer (IRIC)/Université de Montréal, and Southern Research Institute. Story 3 Clinical-stage drug developer Aurinia Pharmaceuticals last week announced the pricing of secondary public offering for gross proceeds of approximately $150.5 million US. As part of the offereing the company is selling 22.3 million shares at $6.75 per share. Leerink Partners LLC and Cantor Fitzgerald & Co. are acting as joint book-running managers for the Offering, that is expected to close March 20th. The cash will be very beneficial as the Victoria-based company intends to initiate a Phase 3 trial for its lead drug candidate, voclosporin, in treating lupus nephritis. The trial will commence in the second quarter. The drug successfully went through a positive 48-week data phase 2b trial in 2016 and 2017, and seems on track to becoming the first drug to demonstrate a clear benefit for the disease. As an aside, Aurinia’s stock had hit an all-time high of $10.50 per share on March 13, the eve of the public offering announcement. By offering its shares at $6.75 the next day, new investors received a 36 percent discount. Canada’s Motley Fool reported that while it may seem as if investors are getting a raw deal, it should be noted that the stock began 2017 at just $2 per share. Motley Fool further commented that there are only 53.45 million shares outstanding today, and the company ended 2016 with less than $40 million in cash. In other words, while the number of shares will be diluted by 41.7%, the company will more than quadruple its cash. Story 4 In Toronto,  a team of cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high-grade serous ovarian cancer, the most common and lethal subtype of the disease. The findings, featured on the cover of the March 7 issue of Cell Reports, show that patients with high levels of the biomarker, CD151, have a poor prognosis, says lead author Mauricio Medrano, a molecular biologist and research associate at Princess Margaret Cancer Centre, University Health Network. “Ovarian cancer is many diseases,” says Dr. Medrano. “By identifying CD151 and its underlying role in cancer cell survival, we hope to develop a therapy to target it. As a marker for poor prognosis, with further research, there is the potential to develop a clinical screening tool to help personalize cancer treatment for patients.” The research was led by principal investigator Dr. Robert Rottapel, senior scientist and Professor, Departments of Medical Biophysics and Immunology, University of Toronto. In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high-grade serous ovarian cancer origin. The team further analysed tissue samples from a cohort of approximately 1,000 patients to establish the correlation of high levels of CD151 to poor prognosis. Dr. Medrano says the study provides a lot of new information about other possible targets, not only CD151, that could be important and can provide new ideas for how to target ovarian cancer.” The research was supported by the Ontario Institute for Cancer Research, Ovarian Cancer Canada, the Canadian Ovarian Cancer Research Consortium’s biobank funded by the Terry Fox Research Institute, and The Princess Margaret Cancer Foundation. Story 5 Also In Toronto, Researchers at the Ontario Institute for Cancer Research (OICR), together with international collaborators, have invented a technique to avoid a major problem with common laboratory techniques and improve the sensitivity of important cancer tests. The findings, recently published in the journal Nature Protocols, describe a process by which the sensitivity of DNA sequencing can be improved. The technology, called SiMSen-Seq, could aid in detecting the recurrence of cancers, catching possible disease relapses faster than current methods and improving patient outcomes. Essentially the scientists have created a DNA barcode with a hairpin structure that as Dr. Paul Krzyzanowski, Program Manager of OICR’s Genome Technologies Program explains opens up to be read when heated and contracts when cooled. This allows researchers to ‘hide’ the barcode and analyze more patient DNA fragments in a single reaction he says. Cirrently, for DNA sequencing, scientists often use a technique called polymerase chain reaction (PCR) to increase the amount of DNA available from a sample. However, PCR can introduce mistakes that can limit researchers’ ability to detect real mutations in the original DNA molecules. To track the original molecules in a sample, molecular tags called DNA barcodes are added. This technique is essential for sensitive detection of mutations but can lead to other errors, as components of the tags can interfere with each other and affect the final results. Dr. Krzyzanowski led the development of analysis pipeline software used in SiMSen-Seq which flags errors in sequencing results and corrects them computationally. Current genome sequencing technologies return results with error rates of about one per cent, meaning that for researchers to be certain that a mutation exists it has to be detected in a sample at a rate of greater than one per cent. Dr. Krzyanowski says that the SimSen-Seq technology has lowered this error rate 100-fold, meaning that the recurrence of cancers could be detected at lower levels and earlier than before, allowing patients to receive additional treatment sooner. His team has already patented the technique, and while it can conceivably be performed in any molecular biology lab, the group also hopes to make their expertise in using the method available to the research community. Those interested in accessing this service can do so through OICR’s Collaborative Research Resources directory. Story 6 In our final story, three leading players in Canada’s health sciences sector are joining forces to create a novel drug development platform that will help advance new therapeutics for some of the most debilitating conditions such as amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and Parkinson’s disease. The initiative, under the banner of ‘NeuroCDRD’, is jointly led by The Centre for Drug Research and Development (CDRD), the Montreal Neurological Institute and Hospital at McGill University (MNI), and Merck. Its initial focus is the creation of a high-content hiPSC (human-induced pluripotent stem cell) screening platform that will help researchers better model neurological disease. Development of new drugs for neurological diseases has long been hampered by the lack of predictive humanized models, and many treatments that have looked promising in animal studies have in turn failed in subsequent human clinical trials. To mitigate this challenge, this new collaboration will use the MNI’s renowned hiPSC platform and bring together experts from MNI’s neurological and CDRD’s drug screening and assay development teams to develop a new generation of disease-specific research models using patient-derived hiPSCs. The idea is to significantly reduce research timelines and costs, making it possible to develop future hiPSC models for neurological diseases with smaller patient populations. As Gordon McCauley, President and CEO of CDRD explains this collaborative initiative not only combines the cutting-edge science of academia, that it will also benefit from CDRD’s translational abilities, and the commercial resources of a top industry partner like Merck. “By working together, we are a catalyst for Canadian life sciences leading the world,” he said. And that wraps up another weekly episode of the Biotechnology Focus RADIO. A special shout out to Laskey Hart who works tirelessly to produce each weeks show, and to the Biotechnology Focus research team for tracking this weeks stories.  As we’re always on the lookout for your story ideas and podcast suggestions we’d love to hear from you our listeners, to let us know what’s hot on the Canadian biotech scene.  Be sure reach out to us via twitter @biotechfocus, or by email at  press@promotivemedia.ca with your suggestions. And of course, you can also catch up on past episodes online via our podcast portal at www.biotechnologyfocus.ca .

Welcome to Biotechnology Focus Podcast. I’m your host Shawn Lawrence. We kick things off this week with the release of our latest issue of Biotechnology Focus and as such we thought we should give you our listeners a rundown or sneak peak of all the stories you’d see. As most or our listeners know, there are comprehensive changes to the way the Federal Government supports science and innovation in Canada coming with consultations on Canada’s Innovation Agenda drawing to a close and this issue reaches your desk with this Call to Action in mind, beginning with our cover story on the results from our latest Hot Button Issue Survey. The survey was open to everyone in both the private and public sectors and at all organizational levels, from the c-level right on down. In all, 163 of you got back to us with what you’d like to see from the Innovation Agenda. Under the microscope for many of you was one of the biggest sources of government cash for private sector research and innovation in Canada, the Scientific Research and Experimental Development program or SR&ED’s as they are more commonly known. It was interesting to see how many of you rely on this program, and why many of you feel this program needs not only to be maintained but expanded upon. Be sure to check out this and what other priorities were included in our special report. And for further reading on the SR&ED program, Elizabeth Pringle, the National Life Sciences Industry Lead for Ernst & Young LLP’s Business Tax Incentives Practices, discusses recent changes to the program itself while suggesting more alternatives to strengthening the overall tax credit regime for life science companies in Canada, including looking south of the border for some inspiration. Moreover, she highlights some of the recent CRA programs added to help increase tax claim certainty and reduce the administrative burden of applying for SR&EDs including the Pre-Claim Consultation program which launched on June 29 and the Pre-Claim Review (PCR) pilot project which launched August 2. In addition to underlining your priorities that you’d like to get before As most or our listeners know, there are comprehensive changes to the way the Federal Government supports science and innovation in Canada coming with consultations on Canada’s Innovation Agenda drawing to a close and this issue reaches your desk with this Call to Action in mind, beginning with our cover story on the results from our latest Hot Button Issue Survey. The survey was open to everyone in both the private and public sectors and at all organizational levels, from the c-level right on down. In all, 163 of you got back to us with what you’d like to see from the Innovation Agenda. Under the microscope for many of you was one of the biggest sources of government cash for private sector research and innovation in Canada, the Scientific Research and Experimental Development program or SR&ED’s as they are more commonly known. It was interesting to see how many of you rely on this program, and why many of you feel this program needs not only to be maintained but expanded upon. Be sure to check out this and what other priorities were included in our special report. And for further reading on the SR&ED program, Elizabeth Pringle, the National Life Sciences Industry Lead for Ernst & Young LLP’s Business Tax Incentives Practices, discusses recent changes to the program itself while suggesting more alternatives to strengthening the overall tax credit regime for life science companies in Canada, including looking south of the border for some inspiration. Moreover, she highlights some of the recent CRA programs added to help increase tax claim certainty and reduce the administrative burden of applying for SR&EDs including the Pre-Claim Consultation program which launched on June 29 and the Pre-Claim Review (PCR) pilot project which launched August 2. In addition to underlining your priorities that you’d like to get before government, this issue also spotlights what makes Canadian biotech great, and highlights some of the areas we can become stronger. It starts with Wayne Schnarr’s roundup piece, “Looking for success stories in Canadian Healthcare.” As he explains, measuring success in Canada’s health technology sector is no easy task, and varies depending on one’s perspective. His article looks at the Canadian biotech landscape from the viewpoint of an investor and reminds us that they judge successful companies differently than government, economic development offices and the companies themselves. With the investors wish list in mind, he highlights some Canadian companies to keep an eye on, including one who is featured later in this podcast Cynapsus. Unfortunately, investors may have missed the boat on that company, but we’ll get to that later. Next in our editorial lineup TO Health’s Ella Korets-Smith, Montreal In Vivo’s Frank Beraud and Teralys Capital’s Cedric Bisson cowritten piece “Canada Poised to be best in the World in Life Sciences Sector” recognizes Canada as a world class biotech hub whose greatest strength is working together to promote our successes in this arena. However, they add that there is still room to grow, and we must begin by looking to other jurisdictions for best practices especially in areas such as venture capital investment. Next, Zymeworks lead man Ali Tehrani, no stranger to success, and perhaps the type of entrepreneur we need to hear more ideas from on how to improve the industry, asks the question why isn’t Canadian biotech with all its great science, visionary entrepreneurs and angel investors, ranked among the best in the world. In addition to posing the question, he endevors to answer it, offering three near and long-term solutions. We have all this and more packed into this issue, so be sure to sign up for our digital edition service to see this issue and past issues as well. Story 2 Our first news story this week is a science story, and features a breast cancer research breakthrough. Specifically, a team of researchers in Canada have discovered that mutations found outside of genes that accumulate in estrogen receptor positive breast tumours throughout their development act as the dominant culprits that drive the disease. The multi-institutional research team collaborated with the Princess Margaret Genomics Centre and Bioinformatics group to analyze changes in the DNA sequence that accumulate in patients’ tumours with respect to the epigenetic identity of estrogen receptor-positive breast cancer cells.. The research, published online in Nature Genetics, focuses on the most common type of breast cancer, estrogen receptor positive, and was led by principal investigator Dr. Mathieu Lupien, senior scientist, Princess Margaret Cancer Centre, University Health Network and associate professor in the Department of Medical Biophysics, University of Toronto. His team investigated acquired mutations found outside of genes through the power of epigenetics, and identified that functional regulatory components can be altered to impact the expression of genes to promote breast cancer development. Dr. Lupien discusses the study in the following audio provided by UHN Toronto Dr.Lupien’s research builds on a previous study that identified why 44 known genetic variations increased breast cancer risk (Nature Genetics, Sept. 23, 2012). He adds that the convergence of more knowledge about inherited risk variants and the role of acquired mutations should readily enable translating the science into more precise clinical tests to diagnose and monitor patients. His work was funded by The National Cancer Institute at the National Institute of Health, The Princess Margaret Cancer Foundation, Canadian Cancer Society, Susan G. Komen Foundation, the Ontario Institute for Cancer Research, the Canadian Institute of Health Research and a Movember Rising Star award from Prostate Cancer Canada. Story 3 Enerkem Inc., a Canadian headquartered waste-to- biofuels and chemicals producer, has obtained certification from the International Sustainability and Carbon Certification (ISCC) system and will now be able to begin biomethanol production at its Biofuels full-scale facility in Edmonton,AB. According to the company the third-party certification confirms that Enerkem meets high ecological and social sustainability requirements. Enerkem makes biofuels and renewable chemicals from non-recyclable municipal solid waste. The company owns a full-scale commercial facility in Alberta as well as a demonstration plant and a pilot facility in Quebec. The company is also developing additional biorefineries in North America and globally, based on its modular manufacturing approach. With the certification, the Edmonton biorefinery is now the first ISCC certified plant in the world to convert municipal solid waste into biomethanol. Story 4 In business news, Laval’s ProMetic Life Sciences has entered into a binding agreement to acquire Belleville, Ontario’s Telesta Therapeutics in an all share transaction. By way of a plan of arrangement under the Canada Business Corporations Act, ProMetic will acquire all of the share capital of Telesta at a share price of $0.14 payable in ProMetic common shares. The number of common shares to be issued by ProMetic will be based on the volume-weighted average closing price (VWAP) of ProMetic’s common shares for the five (5) trading days prior to the closing date of the acquisition. According to ProMetic, the deal gives the company the opportunity for further integration of its manufacturing capabilities and longer term capacity expansion in a 150,000 sq. ft. facility in Belleville, ON. At the same time it gives  ProMetic  a significant foothold in Ontario, consolidating its presence as a major player in the Canadian market. Completion of the deal is subject to the approval of Telesta’s shareholders and a number of customary closing conditions including court and regulatory approvals (such as the approval of the Toronto Stock Exchange). The acquisition is expected to close in early November, 2016. Story 5 Rapid infectious disease test developer bioLytical Laboratories has filed two patent applications with the U.S. Patent and Trademark Office relating to its multiple colour rapid detection assay systems for the detection of antibodies to pathogens including Zika and other flaviviruses. The two new patent applications are based on the company’s INSTI platform and describe methods and kits allowing either simultaneous or sequential detection of different antibody classes to multiple pathogens using a single sample of blood or blood product. The first patent application describes a method for detecting active or past infection using Zika as an example. The second patent application describes a method for differentiating early from later stages of infection. According to the company, these technology breakthroughs could revolutionize point-of- care rapid assays for detection of acute infections including Zika. The Flaviviridae family has become a major concern in many areas of South America and more recently in the continental U.S.  As of early February 2016, the Brazil Ministry of Health has estimated that 500,000 to 1,500,000 cases of Zika virus disease have occurred since the beginning of the outbreak. The company says that with the high degree of cross-reactivity within the flaviviridae family, a diagnostic assay that can rapidly detect and differentiate between them, and determine new vs old infection, is of upmost importance. Story 6 Our final, and perhaps biggest story this week is a Canadian biotech business news story with Marlbourough, MA based-Sunovion Pharmaceuticals announcing that it is buying Toronto’s Cynapsus Therapeutics Inc. for approximately CDN$820 million. The transaction is the biggest the industry has seen in awhile for sure and has already received unanimous approval by the board of directors of both companies and The acquisition will be funded with cash on hand and is expected to close in the fourth quarter of 2016 (third quarter of Sunovion’s fiscal year). Pursuant to the terms of the agreement, and upon closing of the proposed transaction, shareholders of Cynapsus will receive US$40.50 per common share in cash, and holders of warrants and stock options will receive a cash payment equal to the difference between US$40.50 and the exercise price of such warrant or stock option. The offer of US$40.50 per common share in cash represents a premium of 123 per cent based on the volume weighted average closing price of Cynapsus’ common shares on the NASDAQ Global Market for the last twenty trading days. As part of the acquisition, Sunovion is getting Cynapsus’ lead product candidate, APL-130277, a sublingual thin film formulation of apomorphine designed to be an easy-to- use on-demand treatment option for managing OFF episodes associated with Parkinson’s disease (PD), a chronic, progressive neurodegenerative disease that affects more than four million worldwide. One of the biggest benefits of the sublingual thin film delivery of apomorphine is that avoids the normal gastrointestinal route of delivery used by most PD medications. Prior to the deal, Cynapsus had just announced that the Phase 3 clinical program for APL-130277 was nearing completion and that the company had plans to submit a new drug application (NDA) to the FDA in the first half of 2017.Nobuhiko Tamura, chairman and CEO, Sunovion said that his company sees APL-130277 as a novel late-stage candidate with the potential to make a real difference for patients and their families. He adds that Sunovian has high regard for the Cynapsus team led by Anthony Giovinazzo, president and CEO of Cynapsus and the work they have done with the APL-130277 program. For Cynapsus, the deal culminates years of dedicated work, and Anthony J. Giovinazzo, president and CEO, Cynapsus believes Sunovian is the ideal company to take APL-130277 forward. values Cynapsus at approximately CDN$820 million. The transaction will be completed by way of a plan of arrangement under the Canada Business Corporations Act. The arrangement will require approval of at least two-thirds of the votes cast by Cynapsus shareholders and warrantholders voting together as a single class at a special meeting of such securityholders of Cynapsus. This meeting will be held in October. With that we’ve come to the end of this week’s program. We hope you enjoyed it. A big thanks to our production manager Laskey Hart and the rest of the Biotechnology Focus team. You can find past episodes online at www.biotechnologyfocus.ca and we’re always looking for your feedback, story ideas and suggestions so we’d love to hear from you. Simply reach out to us on twitter: @BiotechFocus or by email biotechnology_focus@promotive.net.

Jayne Danska, PhD, Professor, Dept. of Immunology and Dept. of Medical Biophysics at University of Toronto

Join Sarah Ballantyne, founder of award-winning blog The Paleo Mom, for a discussion of autoimmune disease and the Paleo diet. With a Ph.D. in Medical Biophysics, Ballantyne bases her approach to the Paleo lifestyle on established scientific concepts. Listen as she discusses both the scientific and the emotional-psychological hurdles of the Paleo lifestyle. Learn about … The post The Tricky Language of Food with Sarah Ballantyne appeared first on Paleo Blog.

Peter A. Levine, Ph.D. is the originator and developer of Somatic Experiencing® and the Director of The Somatic Experiencing Trauma Institute.Peter holds doctorate degrees in Medical Biophysics and in Psychology and during his thirty five-year study of stress and trauma, has contributed to a variety of scientific and popular publications.Among his many accomplishments…Peter has been stress consultant for NASA in the development of the first Space Shuttle; he's been a member of the Institute of World Affairs Task Force with Psychologists for Social Responsibility and has also served on the APA initiative for response to large scale disaster and Ethno-political warfare.He is on the ‘distinguished faculty’ of Santa Barbara Graduate Institute and is a Senior Fellow at The Meadows Addiction and Trauma Treatment Center in Wickenburg, Arizona.Peter is the author of the best selling book Waking the Tiger - Healing Trauma, (published in twenty languages) as well as four audio learning series for Sounds True including the book CD, Healing Trauma, a Pioneering Program in Restoring the Wisdom of Our Bodies; and Sexual Healing, Transforming the Sacred Wound.He is the co-author of Trauma through a Child’s Eyes, Awakening the Ordinary Miracle of Healing. And Trauma-Proofing Your Kids, A Parents Guide for Instilling Confidence, Joy and Resilience. Support this podcast at — https://redcircle.com/the-trauma-therapist-podcast-with-guy-macpherson-phd-inspiring-interviews-with-thought-leaders-in-the-field-of-trauma/donationsWant to advertise on this podcast? Go to https://redcircle.com/brands and sign up.

Peter A. Levine, Ph.D. is the originator and developer of Somatic Experiencing® and the Director of The Somatic Experiencing Trauma Institute. Peter holds doctorate degrees in Medical Biophysics and in Psychology and during his thirty five-year study of stress and trauma, has contributed to a variety of scientific and popular publications. Among his many accomplishments… Peter has been stress consultant for NASA in the development of the first Space Shuttle; he's been a member of the Institute of World Affairs Task Force with Psychologists for Social Responsibility and has also served on the APA initiative for response to large scale disaster and Ethno-political warfare. He is on the ‘distinguished faculty’ of Santa Barbara Graduate Institute and is a Senior Fellow at The Meadows Addiction and Trauma Treatment Center in Wickenburg, Arizona. Peter is the author of the best selling book Waking the Tiger - Healing Trauma, (published in twenty languages) as well as four audio learning series for Sounds True including the book CD, Healing Trauma, a Pioneering Program in Restoring the Wisdom of Our Bodies; and Sexual Healing, Transforming the Sacred Wound. He is the co-author of Trauma through a Child’s Eyes, Awakening the Ordinary Miracle of Healing. And Trauma-Proofing Your Kids, A Parents Guide for Instilling Confidence, Joy and Resilience.  Support this podcast at — https://redcircle.com/the-trauma-therapist-podcast-with-guy-macpherson-phd-inspiring-interviews-with-thought-leaders-in-the-field-of-trauma/donationsWant to advertise on this podcast? Go to https://redcircle.com/brands and sign up.