Podcasts about sleuthing

Sleuthing over viral Deion Sanders quote full 924 Tue, 25 Mar 2025 10:39:23 +0000 8LvqAB67Q9N7mQmMTKRRwZR6otyajHK1 nfl,sports,football,cleveland browns The Ken Carman Show with Anthony Lima nfl,sports,football,cleveland browns Sleuthing over viral Deion Sanders quote The only place to talk about the Cleveland sports scene is with Ken Carman and Anthony Lima. The two guide listeners through the ups and downs of being a fan of the Browns, Cavaliers, Guardians and Ohio State Buckeyes in Northeast Ohio. They'll help you stay informed with breaking news, game coverage, and interviews with top personalities.Catch The Ken Carman Show with Anthony Lima live Monday through Friday (6 a.m. - 10 a.m ET) on 92.3 The Fan, the exclusive audio home of the Browns, or on the Audacy app. For more, follow the show on X @KenCarmanShow. 2024 © 2021 Audacy, Inc. Sports False https://player.amperwavepodcasting.com?feed-link=htt

Hour 1: Sleuthing Sanders, ALN, Accepting Abdul Carter full 2055 Tue, 25 Mar 2025 14:25:19 +0000 xnGLDlf5E8D0LeFLKzyrBY48rj5rkNRi sports The Ken Carman Show with Anthony Lima sports Hour 1: Sleuthing Sanders, ALN, Accepting Abdul Carter The only place to talk about the Cleveland sports scene is with Ken Carman and Anthony Lima. The two guide listeners through the ups and downs of being a fan of the Browns, Cavaliers, Guardians and Ohio State Buckeyes in Northeast Ohio. They'll help you stay informed with breaking news, game coverage, and interviews with top personalities.Catch The Ken Carman Show with Anthony Lima live Monday through Friday (6 a.m. - 10 a.m ET) on 92.3 The Fan, the exclusive audio home of the Browns, or on the Audacy app. For more, follow the show on X @KenCarmanShow. 2024 © 2021 Audacy, Inc. Sports False https://player.amperwavepodcasting.com

Funding for the NIH and US biomedical research is imperiled at a momentous time of progress. Exemplifying this is the work of Dr. Anna Greka, a leading physician-scientist at the Broad Institute who is devoted to unlocking the mysteries of rare diseases— that cumulatively affect 30 million Americans— and finding cures, science supported by the NIH.A clip from our conversationThe audio is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.Transcript with audio and external linksEric Topol (00:06):Well, hello. This is Eric Topol from Ground Truths, and I am really delighted to welcome today, Anna Greka. Anna is the president of the American Society for Clinical Investigation (ASCI) this year, a very prestigious organization, but she's also at Mass General Brigham, a nephrologist, a cell biologist, a physician-scientist, a Core Institute Member of the Broad Institute of MIT and Harvard, and serves as a member of the institute's Executive Leadership Team. So we got a lot to talk about of all these different things you do. You must be pretty darn unique, Anna, because I don't know any cell biologists, nephrologists, physician-scientist like you.Anna Greka (00:48):Oh, thank you. It's a great honor to be here and glad to chat with you, Eric.Eric Topol (00:54):Yeah. Well, I had the real pleasure to hear you speak at a November conference, the AI for Science Forum, which we'll link to your panel. Where I was in a different panel, but you spoke about your extraordinary work and it became clear that we need to get you on Ground Truths, so you can tell your story to everybody. So I thought rather than kind of going back from the past where you were in Greece and somehow migrated to Boston and all that. We're going to get to that, but you gave an amazing TED Talk and it really encapsulated one of the many phenomenal stories of your work as a molecular sleuth. So maybe if you could give us a synopsis, and of course we'll link to that so people could watch the whole talk. But I think that Mucin-1 or MUC1, as you call it, discovery is really important to kind of ground our discussion.A Mysterious Kidney Disease Unraveled Anna Greka (01:59):Oh, absolutely. Yeah, it's an interesting story. In some ways, in my TED Talk, I highlight one of the important families of this story, a family from Utah, but there's also other important families that are also part of the story. And this is also what I spoke about in London when we were together, and this is really sort of a medical mystery that initially started on the Mediterranean island of Cyprus, where it was found that there were many families in which in every generation, several members suffered and ultimately died from what at the time was a mysterious kidney disease. This was more than 30 years ago, and it was clear that there was something genetic going on, but it was impossible to identify the gene. And then even with the advent of Next-Gen sequencing, this is what's so interesting about this story, it was still hard to find the gene, which is a little surprising.Anna Greka (02:51):After we were able to sequence families and identify monogenic mutations pretty readily, this was still very resistant. And then it actually took the firepower of the Broad Institute, and it's actually from a scientific perspective, an interesting story because they had to dust off the old-fashioned Sanger sequencing in order to get this done. But they were ultimately able to identify this mutation in a VNTR region of the MUC1 gene. The Mucin-1 gene, which I call a dark corner of the human genome, it was really, it's highly repetitive, very GC-rich. So it becomes very difficult to sequence through there with Next-Gen sequencing. And so, ultimately the mutation of course was found and it's a single cytosine insertion in a stretch of cytosines that sort of causes this frameshift mutation and an early stop codon that essentially results in a neoprotein like a toxic, what I call a mangled protein that sort of accumulates inside the kidney cells.Anna Greka (03:55):And that's where my sort of adventure began. It was Eric Lander's group, who is the founding director of the Broad who discovered the mutation. And then through a conversation we had here in Boston, we sort of discovered that there was an opportunity to collaborate and so that's how I came to the Broad, and that's the beginnings of this story. I think what's fascinating about this story though, that starts in a remote Mediterranean island and then turns out to be a disease that you can find in every continent all over the world. There are probably millions of patients with kidney disease in whom we haven't recognized the existence of this mutation. What's really interesting about it though is that what we discovered is that the mangled protein that's a result of this misspelling of this mutation is ultimately captured by a family of cargo receptors, they're called the TMED cargo receptors and they end up sort of grabbing these misfolded proteins and holding onto them so tight that it's impossible for the cell to get rid of them.Anna Greka (04:55):And they become this growing heap of molecular trash, if you will, that becomes really hard to manage, and the cells ultimately die. So in the process of doing this molecular sleuthing, as I call it, we actually also identified a small molecule that actually disrupts these cargo receptors. And as I described in my TED Talk, it's a little bit like having these cargo trucks that ultimately need to go into the lysosome, the cells recycling facility. And this is exactly what this small molecule can do. And so, it was just like a remarkable story of discovery. And then I think the most exciting of all is that these cargo receptors turn out to be not only relevant to this one mangled misshapen protein, but they actually handle a completely different misshapen protein caused by a different genetic mutation in the eye, causing retinitis pigmentosa, a form of blindness, familial blindness. We're now studying familial Alzheimer's disease that's also involving these cargo receptors, and there are other mangled misshapen proteins in the liver, in the lung that we're now studying. So this becomes what I call a node, like a nodal mechanism that can be targeted for the benefit of many more patients than we had previously thought possible, which has been I think, the most satisfying part about this story of molecular sleuthing.Eric Topol (06:20):Yeah, and it's pretty extraordinary. We'll put the figure from your classic Cell paper in 2019, where you have a small molecule that targets the cargo receptor called TMED9.Anna Greka (06:34):Correct.Expanding the MissionEric Topol (06:34):And what's amazing about this, of course, is the potential to reverse this toxic protein disease. And as you say, it may have applicability well beyond this MUC1 kidney story, but rather eye disease with retinitis pigmentosa and the familial Alzheimer's and who knows what else. And what's also fascinating about this is how, as you said, there were these limited number of families with the kidney disease and then you found another one, uromodulin. So there's now, as you say, thousands of families, and that gets me to part of your sleuth work is not just hardcore science. You started an entity called the Ladders to Cures (L2C) Scientific Accelerator.Eric Topol (07:27):Maybe you can tell us about that because this is really pulling together all the forces, which includes the patient advocacy groups, and how are we going to move forward like this?Anna Greka (07:39):Absolutely. I think the goal of the Ladders to Cures Accelerator, which is a new initiative that we started at the Broad, but it really encompasses many colleagues across Boston. And now increasingly it's becoming sort of a national, we even have some international collaborations, and it's only two years that it's been in existence, so we're certainly in a growth mode. But the inspiration was really some of this molecular sleuthing work where I basically thought, well, for starters, it cannot be that there's only one molecular node, these TMED cargo receptors that we discovered there's got to be more, right? And so, there's a need to systematically go and find more nodes because obviously as anyone who works in rare genetic diseases will tell you, the problem for all of us is that we do what I call hand to hand combat. We start with the disease with one mutation, and we try to uncover the mechanism and then try to develop therapies, and that's wonderful.Anna Greka (08:33):But of course, it's slow, right? And if we consider the fact that there are 30 million patients in the United States in every state, everywhere in the country who suffer from a rare genetic disease, most of them, more than half of them are children, then we can appreciate the magnitude of the problem. Out of more than 8,000 genes that are involved in rare genetic diseases, we barely have something that looks like a therapy for maybe 500 of them. So there's a huge mismatch in the unmet need and magnitude of the problem. So the Ladders to Cures Accelerator is here to address this and to do this with the most modern tools available. And to your point, Eric, to bring patients along, not just as the recipients of whatever we discover, but also as partners in the research enterprise because it's really important to bring their perspectives and of course their partnerships in things like developing appropriate biomarkers, for example, for what we do down the road.Anna Greka (09:35):But from a fundamental scientific perspective, this is basically a project that aims to identify every opportunity for nodes, underlying all rare genetic diseases as quickly as possible. And this was one of the reasons I was there at the AI for Science Forum, because of course when one undertakes a project in which you're basically, this is what we're trying to do in the Ladders to Cures Accelerator, introduce dozens of thousands of missense and nonsense human mutations that cause genetic diseases, simultaneously introduce them into multiple human cells and then use modern scalable technology tools. Things like CRISPR screens, massively parallel CRISPR screens to try to interrogate all of these diseases in parallel, identify the nodes, and then develop of course therapeutic programs based on the discovery of these nodes. This is a massive data generation project that is much needed and in addition to the fact that it will help hopefully accelerate our approach to all rare diseases, genetic diseases. It is also a highly controlled cell perturbation dataset that will require the most modern tools in AI, not only to extract the data and understand the data of this dataset, but also because this, again, an extremely controlled, well controlled cell perturbation dataset can be used to train models, train AI models, so that in the future, and I hope this doesn't sound too futuristic, but I think that we're all aiming for that cell biologists for sure dream of this moment, I think when we can actually have in silico the opportunity to make predictions about what cell behaviors are going to look like based on a new perturbation that was not in the training set. So an experiment that hasn't yet been done on a cell, a perturbation that has not been made on a human cell, what if like a new drug, for example, or a new kind of perturbation, a new chemical perturbation, how would it affect the behavior of the cell? Can we make a predictive model for that? This doesn't exist today, but I think this is something, the cell prediction model is a big question for biology for the future. And so, I'm very energized by the opportunity to both address this problem of rare monogenic diseases that remains an unmet need and help as many patients as possible while at the same time advancing biology as much as we possibly can. So it's kind of like a win-win lifting all boats type of enterprise, hopefully.Eric Topol (12:11):Yeah. Well, there's many things to get to unpack what you've just been reviewing. So one thing for sure is that of these 8,000 monogenic diseases, they have relevance to the polygenic common diseases, of course. And then also the fact that the patient family advocates, they are great at scouring the world internet, finding more people, bringing together communities for each of these, as you point out aptly, these rare diseases cumulatively are high, very high proportion, 10% of Americans or more. So they're not so rare when you think about the overall.Anna Greka (12:52):Collectively.Help From the Virtual Cell?Eric Topol (12:53):Yeah. Now, and of course is this toxic proteinopathies, there's at least 50 of these and the point that people have been thinking until now that, oh, we found a mangled protein, but what you've zeroed in on is that, hey, you know what, it's not just a mangled protein, it's how it gets stuck in the cell and that it can't get to the lysosome to get rid of it, there's no waste system. And so, this is such fundamental work. Now that gets me to the virtual cell story, kind of what you're getting into. I just had a conversation with Charlotte Bunne and Steve Quake who published a paper in December on the virtual cell, and of course that's many years off, but of course it's a big, bold, ambitious project to be able to say, as you just summarized, if you had cells in silico and you could do perturbations in silico, and of course they were validated by actual experiments or bidirectionally the experiments, the real ones helped to validate the virtual cell, but then you could get a true acceleration of your understanding of cell biology, your field of course.Anna Greka (14:09):Exactly.Eric Topol (14:12):So what you described, is it the same as a virtual cell? Is it kind of a precursor to it? How do you conceive this because this is such a complex, I mean it's a fundamental unit of life, but it's also so much more complex than a protein or an RNA because not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions. So this is a bold challenge, right?Anna Greka (14:41):Oh my god, it's absolutely from a biologist perspective, it's the challenge of a generation for sure. We think taking humans to Mars, I mean that's an aspirational sort of big ambitious goal. I think this is the, if you will, the Mars shot for biology, being able to, whether the terminology, whether you call it a virtual cell. I like the idea of saying that to state it as a problem, the way that people who think about it from a mathematics perspective for example, would think about it. I think stating it as the cell prediction problem appeals to me because it actually forces us biologists to think about setting up the way that we would do these cell perturbation data sets, the way we would generate them to set them up to serve predictions. So for example, the way that I would think about this would be can I in the future have so much information about how cell perturbations work that I can train a model so that it can predict when I show it a picture of another cell under different conditions that it hasn't seen before, that it can still tell me, ah, this is a neuron in which you perturbed the mitochondria, for example, and now this is sort of the outcome that you would expect to see.Anna Greka (16:08):And so, to be able to have this ability to have a model that can have the ability to predict in silico what cells would look like after perturbation, I think that's sort of the way that I think about this problem. It is very far away from anything that exists today. But I think that the beginning starts, and this is one of the unique things about my institute, if I can say, we have a place where cell biologists, geneticists, mathematicians, machine learning experts, we all come together in the same place to really think and grapple with these problems. And of course we're very outward facing, interacting with scientists all across the world as well. But there's this sort of idea of bringing people into one institute where we can just think creatively about these big aspirational problems that we want to solve. I think this is one of the unique things about the ecosystem at the Broad Institute, which I'm proud to be a part of, and it is this kind of out of the box thinking that will hopefully get us to generate the kinds of data sets that will serve the needs of building these kinds of models with predictive capabilities down the road.Anna Greka (17:19):But as you astutely said, AlphaFold of course was based on the protein database existing, right? And that was a wealth of available information in which one could train models that would ultimately be predictive, as we have seen this miracle that Demi Hassabis and John Jumper have given to humanity, if you will.Anna Greka (17:42):But as Demis and John would also say, I believe is as I have discussed with them, in fact, the cell prediction problem is really a bigger problem because we do not have a protein data bank to go to right now, but we need to create it to generate these data. And so, my Ladders to Cures Accelerator is here to basically provide some part of the answer to that problem, create this kind of well-controlled database that we need for cell perturbations, while at the same time maximizing our learnings about these fully penetrant coding mutations and what their downstream sequelae would be in many different human cells. And so, in this way, I think we can both advance our knowledge about these monogenic diseases, build models, hopefully with predictive capabilities. And to your point, a lot of what we will learn about this biology, if we think that it involves 8,000 or more out of the 20,000 genes in our genome, it will of course serve our understanding of polygenic diseases ultimately as well as we go deeper into this biology and we look at the combinatorial aspects of what different mutations do to human cells. And so, it's a huge aspirational problem for a whole generation, but it's a good one to work on, I would say.Learning the Language of Life with A.I. Eric Topol (19:01):Oh, absolutely. Now I think you already mentioned something that's quite, well, two things from what you just touched on. One of course, how vital it is to have this inner or transdisciplinary capability because you do need expertise across these vital areas. But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that, but it's not. Of course, as you mentioned, we have genome editing which allows to look at lots of different genome perturbations, like the single letter change that you found in MUC1 pathogenic critical mutation. There's also the AI world which is blossoming like I've never seen. In fact, I had in Science this week about learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human cell.Eric Topol (20:14):So this is exploding. As you said, the expertise in computer science and then this whole idea that you could take these powerful tools and do as you said, which is the need to accelerate, we just can't sit around here when there's so much discovery work to be done with the scalability, even though it might take years to get to this artificial intelligence virtual cell, which I have to agree, everyone in biology would say that's the holy grail. And as you remember at our conference in London, Demi Hassabis said that's what we'd like to do now. So it has the attention of leaders in AI around the world, obviously in the science and the biomedical community like you and many others. So it is an extraordinary time where we just can't sit still with these tools that we have, right?Anna Greka (21:15):Absolutely. And I think this is going to be, you mentioned the ASCI presidency in the beginning of our call. This is going to be the president gets to give an address at the annual meeting in Chicago. This is going to be one of the points I make, no matter what field in biomedicine we're in, we live in, I believe, a golden era and we have so many tools available to us that we can really accelerate our ability to help more patients. And of course, this is our mandate, the most important stakeholders for everything that we do as physician-scientists are our patients ultimately. So I feel very hopeful for the future and our ability to use these tools and to really make good on the promise of research is a public good. And I really hope that we can advance our knowledge for the benefit of all. And this is really an exciting time, I think, to be in this field and hopefully for the younger colleagues a time to really get excited about getting in there and getting involved and asking the big questions.Career ReflectionsEric Topol (22:21):Well, you are the prototype for this and an inspiration to everyone really, I'm sure to your lab group, which you highlighted in the TED Talk and many other things that you do. Now I want to spend a little bit of time about your career. I think it's fascinating that you grew up in Greece and your father's a nephrologist and your mother's a pathologist. So you had two physicians to model, but I guess you decided to go after nephrology, which is an area in medicine that I kind of liken it to Rodney Dangerfield, he doesn't get any respect. You don't see many people that go into nephrology. But before we get to your decision to do that somehow or other you came from Greece to Harvard for your undergrad. How did you make that connect to start your college education? And then subsequently you of course you stayed in Boston, you've never left Boston, I think.Anna Greka (23:24):I never left. Yeah, this is coming into 31 years now in Boston.Anna Greka (23:29):Yeah, I started as a Harvard undergraduate and I'm now a full professor. It's kind of a long, but wonderful road. Well, actually I would credit my parents. You mentioned that my father, they're both physician-scientists. My father is now both retired, but my father is a nephrologist, and my mother is a pathologist, actually, they were both academics. And so, when we were very young, we lived in England when my parents were doing postdoctoral work. That was actually a wonderful gift that they gave me because I became bilingual. It was a very young age, and so that allowed me to have this advantage of being fluent in English. And then when we moved back to Greece where I grew up, I went to an American school. And from that time, this is actually an interesting story in itself. I'm very proud of this school.Anna Greka (24:22):It's called Anatolia, and it was founded by American missionaries from Williams College a long time ago, 150 and more years ago. But it is in Thessaloniki, Greece, which is my hometown, and it's a wonderful institution, which gave me a lot of gifts as well, preparing me for coming to college in the United States. And of course, I was a good student in high school, but what really was catalytic was that I was lucky enough to get a scholarship to go to Harvard. And that was really, you could say the catalyst that propelled me from a teenager who was dreaming about a career as a physician-scientist because I certainly was for as far back as I remember in fact. But then to make that a reality, I found myself on the Harvard campus initially for college, and then I was in the combined Harvard-MIT program for my MD PhD. And then I trained in Boston at Mass General in Brigham, and then sort of started my academic career. And that sort of brings us to today, but it is an unlikely story and one that I feel still very lucky and blessed to have had these opportunities. So for sure, it's been wonderful.Eric Topol (25:35):We're the ones lucky that you came here and set up shop and you did your productivity and discovery work and sleuthing has been incredible. But I do think it's interesting too, because when you did your PhD, it was in neuroscience.Anna Greka (25:52):Ah, yes. That's another.Eric Topol (25:54):And then you switch gears. So tell us about that?Anna Greka (25:57):This is interesting, and actually I encourage more colleagues to think about it this way. So I have always been driven by the science, and I think that it seems a little backward to some people, but I did my PhD in neuroscience because I was interested in understanding something about these ion channels that were newly discovered at the time, and they were most highly expressed in the brain. So here I was doing work in the brain in the neuroscience program at Harvard, but then once I completed my PhD and I was in the middle of my residency training actually at Mass General, I distinctly remember that there was a paper that came out that implicated the same family of ion channels that I had spent my time understanding in the brain. It turned out to be a channelopathy that causes kidney disease.Anna Greka (26:43):So that was the light bulb, and it made me realize that maybe what I really wanted to do is just follow this thread. And my scientific curiosity basically led me into studying the kidney and then it seemed practical therefore to get done with my clinical training as efficiently as possible. So I finished residency, I did nephrology training, and then there I was in the lab trying to understand the biology around this channelopathy. And that sort of led us into the early projects in my young lab. And in fact, it's interesting we didn't talk about that work, but that work in itself actually has made it all the way to phase II trials in patients. This was a paper we published in Science in 2017 and follow onto that work, there was an opportunity to build this into a real drug targeting one of these ion channels that has made it into phase II trials. And we'll see what happens next. But it's this idea of following your scientific curiosity, which I also talked about in my TED Talk, because you don't know to what wonderful places it will lead you. And quite interestingly now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye in brain. So I tell people, do not limit yourself to whatever someone says your field is or should be. Just follow your scientific curiosity and usually that takes you to a lot more interesting places. And so, that's certainly been a theme from my career, I would say.Eric Topol (28:14):No, I think that's perfect. Curiosity driven science is not the term. You often hear hypothesis driven or now with AI you hear more AI exploratory science. But no, that's great. Now I want to get a little back to the AI story because it's so fascinating. You use lots of different types of AI such as cellular imaging would be fusion models and drug discovery. I mean, you've had drug discovery for different pathways. You mentioned of course the ion channel and then also as we touched on with your Cell paper, the whole idea of targeting the cargo receptor with a small molecule and then things in between. You discussed this of course at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state-of-the-art science that you're doing?Anna Greka (29:17):Sure, yeah, thank you. I think there are many ways in which even for quite a long time before AI became such a well-known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time. And so, this is actually a form of AI that we use in order to process millions of images. My lab has by produced probably more than 20 million images over the last few years, maybe five to six years. And so, if you can imagine it's impossible for any human to process this many images and make sense of them. So of course, we've been using machine learning that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.Anna Greka (30:06):And so, there's multiple different kinds of perturbations that we do to cells, whether we're using CRISPR or base editing to make, for example, genome wide or genome scale perturbations or small molecules as we have done as well in the past. These are all ways in which we are then using machine learning to read out the effects in images of cells that we're looking at. So that's one way in which machine learning is used in our daily work, of course, because we study misshape and mangled proteins and how they are recognized by these cargo receptors. We also use AlphaFold pretty much every day in my lab. And this has been catalytic for us as a tool because we really are able to accelerate our discoveries in ways that were even just three or four years ago, completely impossible. So it's been incredible to see how the young people in my lab are just so excited to use these tools and they're becoming extremely savvy in using these tools.Anna Greka (31:06):Of course, this is a new generation of scientists, and so we use AlphaFold all the time. And this also has a lot of implications of course for some of the interventions that we might think about. So where in this cargo receptor complex that we study for example, might we be able to fit a drug that would disrupt the complex and lead the cargo tracks into the lysosome for degradation, for example. So there's many ways in which AI can be used for all of these functions. So I would say that if we were to organize our thinking around it, one way to think about the use of machine learning AI is around what I would call understanding biology in cells and what in sort of more kind of drug discovery terms you would call target identification, trying to understand the things that we might want to intervene on in order to have a benefit for disease.Anna Greka (31:59):So target ID is one area in which I think machine learning and AI will have a catalytic effect as they already are. The other of course, is in the actual development of the appropriate drugs in a rational way. So rational drug design is incredibly enabled by AlphaFold and all these advances in terms of understanding protein structures and how to fit drugs into them of all different modalities and kinds. And I think an area that we are not yet harnessing in my group, but I think the Ladders to Cures Accelerator hopes to build on is really patient data. I think that there's a lot of opportunity for AI to be used to make sense of medical records for example and how we extract information that would tell us that this cohort of patients is a better cohort to enroll in your trial versus another. There are many ways in which we can make use of these tools. Not all of them are there yet, but I think it's an exciting time for being involved in this kind of work.Eric Topol (32:58):Oh, no question. Now it must be tough when you know the mechanism of these families disease and you even have a drug candidate, but that it takes so long to go from that to helping these families. And what are your thoughts about that, I mean, are you thinking also about genome editing for some of these diseases or are you thinking to go through the route of here's a small molecule, here's the tox data in animal models and here's phase I and on and on. Where do you think because when you know so much and then these people are suffering, how do you bridge that gap?Anna Greka (33:39):Yeah, I think that's an excellent question. Of course, having patients as our partners in our research is incredible as a way for us to understand the disease, to build biomarkers, but it is also exactly creating this kind of emotional conflict, if you will, because of course, to me, honesty is the best policy, if you will. And so, I'm always very honest with patients and their families. I welcome them to the lab so they can see just how long it takes to get some of these things done. Even today with all the tools that we have, of course there are certain things that are still quite slow to do. And even if you have a perfect drug that looks like it fits into the right pocket, there may still be some toxicity, there may be other setbacks. And so, I try to be very honest with patients about the road that we're on. The small molecule path for the toxic proteinopathies is on its way now.Anna Greka (34:34):It's partnered with a pharmaceutical company, so it's on its way hopefully to patients. Of course, again, this is an unpredictable road. Things can happen as you very well know, but I'm at least glad that it's sort of making its way there. But to your point, and I'm in an institute where CRISPR was discovered, and base editing and prime editing were discovered by my colleagues here. So we are in fact looking at every other modality that could help with these diseases. We have several hurdles to overcome because in contrast to the liver and the brain, the kidney for example, is not an organ in which you can easily deliver nucleic acid therapies, but we're making progress. I have a whole subgroup within the bigger group who's focusing on this. It's actually organized in a way where they're running kind of independently from the cell biology group that I run.Anna Greka (35:31):And it's headed by a person who came from industry so that she has the opportunity to really drive the project the way that it would be run milestone driven, if you will, in a way that it would be run as a therapeutics program. And we're really trying to go after all kinds of different nucleic acid therapies that would target the mutations themselves rather than the cargo receptors. And so, there's ASO and siRNA technologies and then also actual gene editing technologies that we are investigating. But I would say that some of them are closer than others. And again, to your question about patients, I tell them honestly when a project looks to be more promising, and I also tell them when a project looks to have hurdles and that it will take long and that sometimes I just don't know how long it will take before we can get there. The only thing that I can promise patients in any of our projects, whether it's Alzheimer's, blindness, kidney disease, all I can promise is that we're working the hardest we possibly can on the problem.Anna Greka (36:34):And I think that is often reassuring I have found to patients, and it's best to be honest about the fact that these things take a long time, but I do think that they find it reassuring that someone is on it essentially, and that there will be some progress as we move forward. And we've made progress in the very first discovery that came out of my lab. As I mentioned to you, we've made it all the way to phase II trials. So I have seen the trajectory be realized, and I'm eager to make it happen again and again as many times as I can within my career to help as many people as possible.The Paucity of Physician-ScientistsEric Topol (37:13):I have no doubts that you'll be doing this many times in your career. No, there's no question about it. It's extraordinary actually. There's a couple of things there I want to pick up on. Physician-scientists, as you know, are a rarefied species. And you have actually so nicely told the story about when you have a physician-scientist, you're caring for the patients that you're researching, which is, most of the time we have scientists. Nothing wrong with them of course, but you have this hinge point, which is really important because you're really hearing the stories and experiencing the patients and as you say, communicating about the likelihood of being able to come up with a treatment or the progress. What are we going to do to get more physician-scientists? Because this is a huge problem, it has been for decades, but the numbers just keep going lower and lower.Anna Greka (38:15):I think you're absolutely right. And this is again, something that in my leadership of the ASCI I have made sort of a cornerstone of our efforts. I think that it has been well-documented as a problem. I think that the pressures of modern clinical care are really antithetical to the needs of research, protected time to really be able to think and be creative and even have the funding available to be able to pursue one's program. I think those pressures are becoming so heavy for investigators that many of them kind of choose one or the other route most often the clinical route because that tends to be, of course where they can support their families better. And so, this has been kind of the conundrum in some ways that we take our best and brightest medical students who are interested in investigation, we train them and invest in them in becoming physician-scientists, but then we sort of drop them at the most vulnerable time, which is usually after one completes their clinical and scientific training.Anna Greka (39:24):And they're embarking on early phases of one's careers. It has been found to be a very vulnerable point when a lot of people are now in their mid-thirties or even late thirties perhaps with some family to take care of other burdens of adulthood, if you will. And I think what it becomes very difficult to sustain a career where one salary is very limited due to the research component. And so, I think we have to invest in our youngest people, and it is a real issue that there's no good mechanism to do that at the present time. So I was actually really hoping that there would be an opportunity with leadership at the NIH to really think about this. It's also been discussed at the level of the National Academy of Medicine where I had some role in discussing the recent report that they put out on the biomedical enterprise in the United States. And it's kind of interesting to see that there is a note made there about this issue and the fact that there needs to be, I think, more generous investment in the careers of a few select physician-scientists that we can support. So if you look at the numbers, currently out of the entire physician workforce, a physician-scientist comprised of less than 1%.Anna Greka (40:45):It's probably closer to 0.8% at this point.Eric Topol (40:46):No, it's incredible.Anna Greka (40:48):So that's really not enough, I think, to maintain the enterprise and if you will, this incredible innovation economy that the United States has had this miracle engine, if you will, in biomedicine that has been fueled in large part by physician investigators. Of course, our colleagues who are non-physician investigators are equally important partners in this journey. But we do need a few of the physician-scientists investigators I think as well, if you really think about the fact that I think 70% of people who run R&D programs in all the big pharmaceutical companies are physician-scientists. And so, we need people like us to be able to work on these big problems. And so, more investment, I think that the government, the NIH has a role to play there of course. And this is important from both an economic perspective, a competition perspective with other nations around the world who are actually heavily investing in the physician-scientist workforce.Anna Greka (41:51):And I think it's also important to do so through our smaller scale efforts at the ASCI. So one of the things that I have been involved in as a council member and now as president is the creation of an awards program for those early career investigators. So we call them the Emerging-Generation Awards, and we also have the Young Physician-Scientist Awards. And these are really to recognize people who are making that transition from being kind of a trainee and a postdoc and have finished their clinical training into becoming an independent assistant professor. And so, those are small awards, but they're kind of a symbolic tap on the shoulder, if you will, that the ASCI sees you, you're talented, stay the course. We want you to become a future member. Don't give up and please keep on fighting. I think that can take us only so far.Anna Greka (42:45):I mean, unless there's a real investment, of course still it will be hard to maintain people in the pipeline. But this is just one way in which we have tried to, these programs that the ASCI offers have been very successful over the last few years. We create a cohort of investigators who are clearly recognized by members of the ASCI is being promising young colleagues. And we give them longitudinal training as part of a cohort where they learn about how to write a grant, how to write a paper, leadership skills, how to run a lab. And they're sort of like a buddy system as well. So they know that they're in it together rather than feeling isolated and struggling to get their careers going. And so, we've seen a lot of success. One way that we measure that is conversion into an ASCI membership. And so, we're encouraged by that, and we hope that the program can continue. And of course, as president, I'm going to be fundraising for that as well, it's part of the role. But it is a really worthy cause because to your point, we have to somehow make sure that our younger colleagues stay the course that we can at least maintain, if not bolster our numbers within the scientific workforce.Eric Topol (43:57):Well, you outlined some really nice strategies and plans. It's a formidable challenge, of course. And we'd like to see billions of dollars to support this. And maybe someday we will because as you say, if we could relieve the financial concerns of people who have curiosity driven ideas.Anna Greka (44:18):Exactly.Eric Topol (44:19):We could do a lot to replenish and build a big physician-scientist workforce. Now, the last thing I want to get to, is you have great communication skills. Obviously, anybody who is listening or watching this.Eric Topol (44:36):Which is another really important part of being a scientist, no less a physician or the hybrid of the two. But I wanted to just go to the backstory because your TED Talk, which has been watched by hundreds of thousands of people, and I'm sure there's hundreds of thousands more that will watch it, but the TED organization is famous for making people come to the place a week ahead. This is Vancouver used to be in LA or Los Angeles area and making them rehearse the talk, rehearse, rehearse, rehearse, which seems crazy. You could train the people there, how to give a talk. Did you have to go through that?Anna Greka (45:21):Not really. I did rehearse once on stage before I actually delivered the talk live. And I was very encouraged by the fact that the TED folks who are of course very well calibrated, said just like that. It's great, just like that.Eric Topol (45:37):That says a lot because a lot of people that do these talks, they have to do it 10 times. So that kind of was another metric. But what I don't like about that is it just because these people almost have to memorize their talks from giving it so much and all this coaching, it comes across kind of stilted and unnatural, and you're just a natural great communicator added to all your other things.Anna Greka (46:03):I think it's interesting. Actually, I would say, if I may, that I credit, of course, I actually think that it's important, for us physician-scientists, again, science and research is a public good, and being able to communicate to the public what it is that we do, I think is kind of an obligation for the fact that we are funded by the public to do this kind of work. And so, I think that's important. And I always wanted to cultivate those communication skills for the benefit of communicating simply and clearly what it is that we do in our labs. But also, I would say as part of my story, I mentioned that I had the opportunity to attend a special school growing up in Greece, Anatolia, which was an American school. One of the interesting things about that is that there was an oratory competition.Anna Greka (46:50):I got very early exposure entering that competition. And if you won the first prize, it was in the kind of ancient Rome way, first among equals, right? And so, that was the prize. And I was lucky to have this early exposure. This is when I was 14, 15, 16 years old, that I was training to give these oratory speeches in front of an audience and sort of compete with other kids who were doing the same. I think these are just wonderful gifts that a school can give a student that have stayed with me for life. And I think that that's a wonderful, yeah, I credit that experience for a lot of my subsequent capabilities in this area.Eric Topol (47:40):Oh, that's fantastic. Well, this has been such an enjoyable conversation, Anna. Did I miss anything that we need to bring up, or do you think we have it covered?Anna Greka (47:50):Not at all. No, this was wonderful, and I thoroughly enjoyed it as well. I'm very honored seeing how many other incredible colleagues you've had on the show. It's just a great honor to be a part of this. So thank you for having me.Eric Topol (48:05):Well, you really are such a great inspiration to all of us in the biomedical community, and we'll be cheering for your continued success and thanks so much for joining today, and I look forward to the next time we get a chance to visit.Anna Greka (48:20):Absolutely. Thank you, Eric.**************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding and support for biomedical research at NIH and other US governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Wally’s luggage struggle, Gene Hackman’s passing, and we answer a would you rather question. You can join our Wally Show Poddies Facebook group at www.facebook.com/groups/WallyShowPoddies

From the archives: 12-1-22Whenever there is an unsolved mystery or murder that grabs the attention of the nation, it also leads to a lot of crazies coming out of the woodwork. It's one thing to follow a case and talk about it on a forum with strangers or friends, it's a whole different thing when you start inserting yourself in the case.Let's dive in and take a look.(commercial at 10:48)to contact me:bobbycapucci@protonmail.comsource:https://www.nbcnews.com/news/us-news/internet-sleuthing-unsolved-university-idaho-slayings-can-extremely-da-rcna59406

In this new episode, Tim Pilleri and Lance Reenstierna speak with author Theresa Payton about cyber security and best practices to keep your online life safe. Theresa M. Payton served as the first female Chief Information Officer for the White House during the President George W. Bush administration and is currently CEO and founder of Fortalice Solutions, a boutique cybersecurity and intelligence services company that's listed in the Global Cybersecurity Top 500. Check out Theresa's work: https://t.co/fFp92E8RVr. Her books: https://www.amazon.com/stores/author/B007ECYE4K. Follow Theresa on Twitter: https://x.com/trackerpayton. Follow Theresa on Facebook: https://www.facebook.com/Fortalice. Follow Missing: TikTok: https://www.tiktok.com/@missingcsm. YouTube: https://www.youtube.com/missingcsm. IG: https://www.instagram.com/MissingCSM/. Twitter: https://twitter.com/MissingCSM. FB: https://www.facebook.com/MissingCSM. Follow Crawlspace: Twitter: https://twitter.com/crawlspacepod . Facebook: https://www.facebook.com/Crawlspacepodcast . Instagram: https://www.Instagram.com/Crawlspacepodcast. TikTok: https://www.tiktok.com/@crawlspacepodcast. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews, Heather Deba, the founder of HD Body Academy.  Heather has helped 22K women regain control of their metabolisms and achieve ideal weight.  She's helping women learn how to study their body to reset their metabolism and maintain weight loss.  Heather helps her clients find value in working on the nervous system aspect of metabolism alongside sleuthing out your metabolism.   What You'll Learn In This Episode: How women over 40 increase their metabolism How to gain muscle fasted while skipping endless hours at the gym How to reset metabolism and stop yoyo dieting Why Heather doesn't recommend quick jumps up in calorie intake like in reverse dieting  Why prolonged caloric deficit on top of working out leads to weight gain A cost effective way to figure out your metabolic rate Why Heather sees food sensitivities as a sign of stress on the body Resources From The Show: Mind Metabolic Boost Kit - @heatherdeba on Instagram - DM her "NewYear" and she will send the kit to you.  Message Heather on Instagram @heatherdeba

Olympic champion Maggie Mac Neil and bestselling thriller author Samantha M. Bailey meet for the first time on air; Antonio Michael Downing and friends Christine Estima and JJ Lee gather for a book club meeting to chat about James by Percival Everett; How reading about the Saskatoon freezing deaths inspired Wiidaaseh's songwriting; and The Girl on the Train author Paula Hawkins answers the Proust Questionnaire on this episode of The Next Chapter.

Ann is a Baby Scoop-era adoptee. Born to teenage parents in the early 1960s, she was adopted when she was not quite two weeks old. She's always known she was adopted. Her adoptive mother told her against the wishes of her adoptive father when she was very young. Knowing caused her a great deal of angst growing up because she felt her adoptive parents were withholding information from her and that coupled with feeling and looking different from her adoptive family was a constant source of cognitive dissonance that lasted into adulthood.As an adult, Ann searched for her birth mother over the years but with little information to go on, and the imperfect search options available to her, she found nothing. It wasn't until her daughter convinced her to take a DNA test in 2019 that solid leads led her first to a maternal cousin and then to her birth mother's family and set her on the journey to discover where she came from, and how it shaped who she's become.You Should Be Grateful: Stories of Race, Identity, and Transracial Adoption by Angela Tucker Closure - Angela Tucker DocumentaryGet 45% off the Magic Mind bundle with with my link:https://www.magicmind.com/ADOPTEEJANJOIN US on March 8th in Atascadero, California - Live Podcast, Un-M-Othered, Jeff Forney & The Innocent People Project + More!Leave your email for more info!Thank you to our Patreons! Join at the $10 level and be part of our monthly ADOPTEE CAFE community. The next meeting is this Saturday, February 1st @ 1 PM ET.RESOURCES for AdopteesS12F Helping AdopteesAdoptee Mentoring SocietyJeff Forney - Innocent People ProjectGregory Luce and Adoptees Rights LawFireside Adoptees Facebook GroupReckoning with the Primal Wound DocumentaryDr. Liz Debetta: Migrating Toward Wholeness MovementMoses Farrow - Trauma therapist and advocateUnraveling Adoption with Beth SyversonAdoptees Connect with Pamela KaranovaSupport the showTo support the show - Patreon.

Happy 2025 from the two broads! So much has happened in the Bravoverse since the new year has started. Paige and Craig broke up, Craig and Austen potentially broke up, and od course Gary is still chasing Daisy. So much to chat about, so little time. Come by and hang out!

We're decking the halls and looking for clues with three holiday-themed old time radio mysteries. Peter Lorre plans the perfect crime, but he may be undone by a surprise gift from his victim in "Back for Christmas" from Suspense (originally aired on CBS on December 23, 1943). Then, it's a tale from The Damon Runyon Theatre - "Dancing Dan's Christmas," the story of a small-time crook who lands in hot water during the holidays. Finally, Bob Bailey deals with a Santa who gets gifts instead of gives them and who may be marked for death in "Christmas in January" from Let George Do It (originally aired on CBS on January 29, 1951).

Is your content feeling stale? Wondering what's working in marketing right now? In this episode of the Boss Mom Podcast, Dana sits down with Shannon McKinstrie, an expert social media strategist, to talk about the shift in marketing trends, why user-generated content is crushing it, and how personal storytelling can help your brand connect and convert.   They dive deep into: Why high-ticket programs are declining and smaller solutions are thriving. How to leverage user-generated content marketing to build trust. Why people are taking longer to buy and how to nurture your audience effectively. Simple content strategies you can implement right now to grow your social presence organically.   If you're ready to simplify your content, make deeper connections, and stand out in today's noisy online space, this episode is packed with actionable insights just for you. What You'll Learn in This Episode: Why polished, high-end content isn't connecting anymore. How user-generated content marketing brings trust and relatability. The power of POV-style storytelling and personal experiences. Why specificity in your messaging is key to attracting your audience. The “Age of Sleuthing” and why the buying process is now a long game. Connect with Shannon McKinstrie: Instagram: @ShannonMcKinstrie LinkedIn: Shannon McKinstrie TikTok: @ShannonMcKinstrie Reels Lab: Learn More Here About Shannon: Shannon is an engaging Social Media Strategist, Trainer & Mentor who guides small business owners into making a big splash online and growing their accounts through proven, organic, and sustainable strategies. Resources Mentioned: Reels Lab: Shannon's go-to program for creating scroll-stopping Instagram Reels that actually work.

Send us a textWelcome back to Headfirst: A Concussion Podcast! Today, we are thrilled to have Dr. Mu Yang with us. Dr. Yang is an Assistant Professor at Columbia University and the Director of the Mouse Neurobehavior Core. With over 25 years of experience, she's made significant contributions to the field of pre-clinical mouse models for human diseases and neurological disorders. In addition to her impressive academic work, Dr. Yang is known for her sharp skills as a research sleuth, uncovering inconsistencies and challenging false research. Dr Yang's began sleuthing in 2020, and her investigative reports have led to over 100 retractions, including an entire book. Perhaps her most high-profile case was her work involving Eliezer Masliah, Lastly Dr Yang's has published over 60 papers, which have been cited more than 8,500 times.  -       Introduction About Dr Yang-       What is Research: (3:04)-       Integrity in Research (6:30)-       What is a Research Sleuth (8:11)-       Beginnings of Investigations (13:04)-       What Happens to Associated Authors (15:00)-       Research Field Set Backs (18:18)-       Examples of Research and Trust (20:46)-       Most Common Forms of Manipulation (23:18)-       Concussion Q-Collar and Sleuthing (25:30)-       Push Back to Sleuthing (30:25)-       Vison for the Future (35:25)   James Smoliga and Q-Collar Episode 40 Dr Mu Yang Google Scholarhttps://scholar.google.com/citations?user=3lctnWAAAAAJ&hl=en Mouse-ology: https://www.mouse-ology.com Twitter/x: @mumumouse2   Subscribe, review and share for new episodes which will drop fortnightlySocial media:Twitter: @first concussionFacebook: Headfirst: A concussion podcastInstagram: Headfirst_ Concussion  Email: headfirstconcussion@gmail.com

Corey Quinn chats with Dylan Etkin, CEO and co-founder of Sleuth. He joins this episode of Screaming Into the Cloud to share his insights on reshaping engineering metrics to prioritize team success. Sleuth emphasizes team-level productivity over individual output, sidestepping controversial metrics like lines of code and focusing on alignment and iterative improvement. By aggregating data from tools like GitHub, Jira, and Datadog, Sleuth provides actionable insights, helping leaders reallocate resources for optimal impact without disrupting unique team workflows. Designed for collaborative review, Sleuth's slide deck-like interface supports meaningful discussions around DORA metrics and deploy tracking. Show Highlights(0:00) Intro(0:51) Sleuth sponsor read(1:12) What Sleuth is(2:02) How Sleuth evaluates engineers' work(5:41) The value that evaluations brings to a business(9:34) Who Dylan usually discusses results with(11:04) Sleuth sponsor read(11:30) The day-to-day experience of using Sleuth(14:23) The importance of meeting people where they are(18:21) The actual outcome of implementing Sleuth(20:27) Why engineering teams should care about metrics(24:27) The interface that people have when they're working with Sleuth(26:23) Where you can find more from SleuthAbout Dylan EtkinDylan was one of the first twenty employees of Atlassian, and a founding engineer and the first architect of Jira. He has led engineering at scale for Bitbucket and Statuspage. He has a Master's in Computer Science from ASU. Dylan is a bit of a space nut and has been seen climbing around the inside of a life-size replica of the Mir space station in Star City Russia.SponsorSleuth: https://www.sleuth.io/ 

Erin Moulton discusses her book, “The Beginner's Guide to Cemetery Sleuthing, Scavenger Hunt,” which is uniquely designed as a workbook. Moulton, a local history librarian at Derry Public Library, shares her journey from genealogy enthusiast to cemetery researcher. The book serves as a practical guide for collecting key details from cemeteries, which can then be further explored in archives for deeper genealogical research.Erin Moulton's book is structured as a workbook to enhance the learning experience through hands-on activities.Techniques in the book include how to extract and interpret data from headstones, such as names, dates, and symbols.Moulton emphasizes the use of local historical resources to aid in locating graves and understanding the broader historical context.The podcast also touches on ethical considerations in cemetery research and the future of genealogical resources with digital archiving. Related Episodes:Episode 203: Recipes on Gravestones with Rosie Grant Episode 246: Uncovering History with Kurt Deion: A Journey to Every Presidential GraveLinks:Erin Moulton's website. Sign up for my newsletter.Need help preserving your photos? Check out Maureen's Preserving Family Photographs ebook Need help identifying family photos? Check out The Family Photo Detective ebookHave a photo you need help identifying? Sign up for photo consultation.About My Guest:Erin E. Moulton writes books and tracks dead people. As a genealogical researcher, she has explored the lives of the departed for over 14 years. Erin is a member of the Association of Professional Genealogists, the New Hampshire Historical Society, and the New Hampshire Society of Genealogists. She holds a B.A. from Emerson College, an M.F.A. from the Vermont College of Fine Arts, and a Certificate in Genealogical Research from Boston University. She is an award-winning author of middle grade and young adult books.  You can find her online at www.erinemoulton.com.About Maureen Taylor:Maureen Taylor, The Photo Detective TM helps clients with photo related genealogical problems. Her pioneering work in historic photo research has earned her the title “the nation's foremost historical photo detective” by The Wall Street Journal and appearances on The View, The Today Show, Pawn Stars, and others.   Learn more at Maureentaylor.comDid you enjoy this episode? Please leave a review on Apple Podcasts. I'm thrilled to be offering something new. Photo investigations. These collaborative one-on-one sessions. Look at your family photos then you and I meet to discuss your mystery images. And find out how each clue and hint might contribute to your family history. Find out more by going to maureentaylor.com and clicking on family photo investigations. Support the show

Bella Mackie joins Gaby for a natter about all things joy. They discuss her new novel and why she has been working on it for such a long time. She also reveals how her Dad is very instrumental in the writing process! There's also a bit of running chat too - and some good mental health advice as well. You can find out more about Bella's new novel hereAnd see Gaby and Bella being a bit silly over on her instagram! (you can also follow Bella too) We hope you enjoy the episode! (and if you do, please like, follow and subscribe - and leave us a little comment too. Remember, we also have a YouTube channel now as well, so you can watch the podcasts if you so desire...) Hosted on Acast. See acast.com/privacy for more information.

Get up to 40% off at cozyearth.com/notforeveryone. Use code NOTFOREVERYONE. __ After the long weekend, Jess and Caroline have important business to cover. They're circling back on the F/M/K situation from last week (with new, helpful info!), on Jess's difficult conversation, and on Jess's hack for saving money. But that's not all on this assortment of matters: they also discuss weird baby names, mispronunciations, and why moving sucks so bad. But it's not over yet! Caroline has done some internet sleuthing and she has a report ready for you, featuring evidence, statistics, and names. Then the duo tackle a WHATADO that questions how appropriate it is to continue dating someone who's set off that little alarm in the back of your head. Is a cheater always a cheater? The answer may surprise you. __ This episode was produced by our prince, Abi Newhouse. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ __ Share with a friend! Follow, rate, and review on your favorite podcasting app! Subscribe on YOUTUBE for full episode video: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@Not4EveryonePod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Plus follow us on INSTAGRAM for more: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@not4everyonepod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@thegoodsitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@jzdebakey⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ And don't forget about our MERCH store: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://not4everyonepod.myshopify.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ __ Intro Music: “Doja Dance” by PALA __ DISCLAIMER: All opinions are our own. We are not therapists or health professionals, or professional of any kind, really. Please see your own professional or counselor for professional support. Do your research and be safe! --- Support this podcast: https://podcasters.spotify.com/pod/show/not4everyonepod/support

To donate to Whole Soul School and Foundation, click here: https://give.cornerstone.cc/wholesoulschoolandfoundation  In Global Spotlight #23, Dr. Terry Cole-Whittaker joins Marie Mohler to talk about Spiritual Sleuthing, Using Discernment, Starting Today With The Next Conscious Breath, Mastering The Now, and more!  Dr. Terry offers a wellspring of incredible stories, insights, and her keen awareness to assist you in remembering your courage, power, wisdom, and soul essence. Dr. Terry Cole-Whittaker is the author of 6 best-selling books: What You Think of Me is None of My Business, New York Times bestseller How to Have More in a Have Not World, The Inner Path, Love and Power in a World Without Limits, Dare to be Great, & Live Your Bliss.  Check them out!To learn more about Dr. Terry Cole-Whittaker, her offerings and published work, and to contact her, please visit her website:  https://terrycolewhittaker.com/To access Dr. Terry Cole-Whittaker's blog, visit: https://terrycolewhittaker.substack.com/  Please share this podcast with friends and family who might resonate and benefit from it.For more information and to check out Marie's channeled messages, songs, and products,  please visit:https://frequencywriter.com​​​​To contact her, send email to:  info@frequencywriter.comTo listen to more amazing podcasts and insightful broadcasts, or to make a donation, visit:  http://www.wholesoulschoolandfoundation.orgTo donate: https://give.cornerstone.cc/wholesoulschoolandfoundationTo shop our apparel: https://www.bonfire.com/store/whole-soul-school-and-foundation/You can follow Marie here:YouTube: https://www.youtube.com/@colorthemagicTwitter: https://twitter.com/marie_mohlerRumble.com: https://rumble.com/c/c-353585​​​​Telegram: https://t.me/wholesoulmasteryUgeTube: https://ugetube.com/@wholesoulmastery​​​​Truth Social: https://truthsocial.com/@frequencywriterTune into Frequency Writer Transmissions & Marinades, Whole Soul Mastery Podcasts with Amazing Guests, and Whole Soul School and Foundation's variety of inspiring podcasts via:Spotify, Apple iTunes, Buzzsprout, Stitcher, iHeartRadio, Google Play Music + other favorite podcast platforms Search:  Whole Soul Mastery or Whole Soul School and FoundationIf would like to support Marie and her work directly, please send donations to: https://buy.stripe.com/3csbIU4v8a52eR2aEEYou can also mail donations to:Whole Soul School and Foundationc/o Marie Mohler400 S. Elliott Rd., Suite D259Chapel Hill, NC 27514Every donation is appreciated! Thank you

To donate to Marie, click here: https://buy.stripe.com/3csbIU4v8a52eR2aEE In Episode #71 of the Live Well Live Whole podcast series, Dr. Terry Cole-Whittaker joins Marie Mohler to talk about Spiritual Sleuthing, Using Discernment, Starting Today With The Next Conscious Breath, Mastering The Now, and more!  Dr. Terry offers a wellspring of incredible stories, insights, and her keen awareness to assist you in remembering your Divine Roots. Dr. Terry Cole-Whittaker is the author of 6 best-selling books: What You Think of Me is None of My Business, New York Times bestseller How to Have More in a Have Not World, The Inner Path, Love and Power in a World Without Limits, Dare to be Great, & Live Your Bliss.  Check them out!To learn more about Dr. Terry Cole-Whittaker, her offerings and published work, and to contact her, please visit her website:  https://terrycolewhittaker.com/To access or subscribe to Dr. Terry's blog, visit: https://terrycolewhittaker.substack.com/  Please share this podcast with friends and family who might resonate and benefit from it.For more information and to check out Marie's channeled messages, songs, and products,  please visit: https://frequencywriter.com​​​​To contact her, send email to:  info@frequencywriter.comTo listen to more amazing podcasts and insightful broadcasts, or to make a donation, visit:  http://www.wholesoulschoolandfoundation.orgTo donate: https://give.cornerstone.cc/wholesoulschoolandfoundationTo shop our apparel: https://www.bonfire.com/store/whole-soul-school-and-foundation/Thank you!You can tune into these messages & more here:YouTube: https://www.youtube.com/@colorthemagicTwitter: https://twitter.com/marie_mohlerRumble.com: https://rumble.com/c/c-353585​​​​Telegram: https://t.me/wholesoulmasteryUgeTube: https://ugetube.com/@wholesoulmastery​​​​Truth Social: https://truthsocial.com/@frequencywriterTune into the Frequency Writer Messages & Marinades, Whole Soul Mastery Podcasts with Amazing Guests, and Whole Soul School and Foundation's variety of inspiring podcasts via:Spotify, Apple iTunes, Buzzsprout, Stitcher, iHeartRadio, Google Play Music + other favorite podcast platforms Search:  Whole Soul Mastery or Whole Soul School and FoundationIf would like to support me and my work directly, please send donations to: https://buy.stripe.com/3csbIU4v8a52eR2aEEYou can also mail donations to:Marie Mohler/Whole Soul Mastery400 S. Elliott Rd., Suite D259Chapel Hill, NC 27514Every donation is appreciated! Thank you

Go dust yourself off; you might be carrying some SENSITIVE information! 07/16/24

Fluent Fiction - Spanish: The Hidden Secrets Beneath Santiago: A Journalist's Quest Find the full episode transcript, vocabulary words, and more:fluentfiction.org/the-hidden-secrets-beneath-santiago-a-journalists-quest Story Transcript:Es: El sol brillaba intensamente sobre Santiago de Compostela, iluminando cada rincón de la ciudad con una luz cálida y dorada.En: The sun shone intensely over Santiago de Compostela, illuminating every corner of the city with a warm, golden light.Es: Era verano y las festividades del Día de Santiago estaban en pleno apogeo.En: It was summer, and the festivities for Saint James's Day were in full swing.Es: Los peregrinos y turistas llenaban las calles estrechas, disfrutando de la música y el ambiente festivo.En: Pilgrims and tourists filled the narrow streets, enjoying the music and festive atmosphere.Es: Lucía caminaba con determinación por la Plaza del Obradoiro.En: Lucía walked determinedly through the Plaza del Obradoiro.Es: Era periodista y estaba investigando unas desapariciones muy extrañas en la ciudad.En: She was a journalist investigating some very strange disappearances in the city.Es: Tenía una hipótesis: estas desapariciones estaban conectadas con la historia y la cultura de Santiago.En: She had a hypothesis: these disappearances were connected to the history and culture of Santiago.Es: Su colega, Manuel, la seguía de cerca, aunque se mostraba escéptico.En: Her colleague, Manuel, followed closely behind, though he remained skeptical.Es: —Lucía, ¿estás segura de esto?En: "Lucía, are you sure about this?"Es: —preguntó Manuel con desconfianza.En: Manuel asked distrustfully.Es: —Sí, Manuel.En: "Yes, Manuel.Es: Tengo que descubrir la verdad.En: I have to uncover the truth.Es: Algo oscuro está ocurriendo aquí y no podemos ignorarlo —respondió Lucía.En: Something dark is happening here, and we cannot ignore it," Lucía replied.Es: Se habían enterado de que Francisco, un misterioso tendero con un pasado vinculado al Camino de Santiago, podría tener información.En: They had heard that Francisco, a mysterious shopkeeper with a past tied to the Camino de Santiago, might have information.Es: Decidieron ir a su tienda, situada en una callejuela cercana a la catedral.En: They decided to go to his shop, located in an alley near the cathedral.Es: Francisco los recibió con una sonrisa, pero había algo en su mirada que inquietaba a Lucía.En: Francisco greeted them with a smile, but there was something in his gaze that unsettled Lucía.Es: Empezó a hacerle preguntas sobre las desapariciones.En: She started asking him questions about the disappearances.Es: —¿Sabes algo sobre estos casos?En: "Do you know anything about these cases?"Es: —preguntó ella.En: she asked.Es: —No sé nada, señorita.En: "I don't know anything, miss.Es: Solo soy un simple tendero —respondió Francisco evasivamente.En: I'm just a simple shopkeeper," Francisco answered evasively.Es: Pero Lucía no estaba convencida.En: But Lucía was not convinced.Es: Notó que Francisco se ponía nervioso, así que decidió seguirlo en secreto.En: She noticed Francisco becoming nervous, so she decided to follow him secretly.Es: Al caer la noche, vieron cómo Francisco cerraba apresuradamente su tienda y se adentraba en las sombras de la ciudad.En: As night fell, they saw Francisco hurriedly close his shop and disappear into the shadows of the city.Es: Lucía y Manuel lo siguieron hasta una puerta oculta en un callejón.En: Lucía and Manuel followed him to a hidden door in an alley.Es: La puerta conducía a un túnel subterráneo.En: The door led to an underground tunnel.Es: Era una red de pasadizos antiguos, usados por peregrinos hace siglos.En: It was a network of ancient passages, used by pilgrims centuries ago.Es: Bajaron con cuidado y descubrieron algo increíble: un pequeño altar con un relicario antiguo.En: They descended carefully and discovered something incredible: a small altar with an ancient reliquary.Es: En ese momento, Francisco se giró y los confrontó.En: At that moment, Francisco turned and confronted them.Es: —¡No deberíais haber venido!En: "You shouldn't have come!"Es: —exclamó con voz grave.En: he exclaimed in a grave voice.Es: —¿Qué está pasando aquí?En: "What's going on here?"Es: —preguntó Lucía, sin retroceder ni un paso.En: asked Lucía, not stepping back.Es: Francisco bajó la cabeza, visiblemente afectado.En: Francisco lowered his head, visibly affected.Es: —Intentaba proteger esto —dijo señalando el relicario—.En: "I was trying to protect this," he said, pointing to the reliquary.Es: Es un objeto sagrado.En: "It's a sacred object.Es: Hay personas malas que quieren apoderarse de él.En: There are bad people who want to take it.Es: Las desapariciones eran un señuelo para alejarlos.En: The disappearances were a decoy to keep them away."Es: Lucía comprendió la magnitud del secreto de Francisco.En: Lucía understood the magnitude of Francisco's secret.Es: Decidió ayudarlo.En: She decided to help him.Es: Juntos, compartieron la historia con las autoridades y consiguieron asegurar el relicario.En: Together, they shared the story with the authorities and managed to secure the reliquary.Es: Lucía escribió un artículo revelando la verdad y honrando la importancia histórica y cultural de Santiago de Compostela.En: Lucía wrote an article revealing the truth and honoring the historical and cultural importance of Santiago de Compostela.Es: Al final, Lucía ganó el respeto y la admiración de sus colegas, incluido Manuel, quien finalmente reconoció su intuición y coraje.En: In the end, Lucía earned the respect and admiration of her colleagues, including Manuel, who finally acknowledged her intuition and courage.Es: Y así, con la ciudad más segura y su historia protegida, Lucía y Manuel celebraron las festividades del Día de Santiago con un nuevo aprecio por los misterios y la rica herencia de su amada ciudad.En: And so, with the city safer and its history protected, Lucía and Manuel celebrated the festivities of Saint James's Day with a newfound appreciation for the mysteries and rich heritage of their beloved city. Vocabulary Words:the sun: el solthe festivities: las festividadesthe pilgrims: los peregrinosthe narrow streets: las calles estrechasthe music: la músicathe atmosphere: el ambientethe determination: la determinaciónthe journalist: la periodistathe hypothesis: la hipótesisthe disappearances: las desaparicionesthe colleague: el colegathe skepticism: el escepticismothe distrust: la desconfianzathe truth: la verdadthe shopkeeper: el tenderothe past: el pasadothe information: la informaciónthe alley: la callejuelathe cathedral: la catedralthe gaze: la miradathe questions: las preguntasthe cases: los casosthe night: la nochethe shadows: las sombrasthe hidden door: la puerta ocultathe underground tunnel: el túnel subterráneothe network: la redthe passages: los pasadizosthe altar: el altarthe reliquary: el relicario

Today's guest is Herb Greenberg, a veteran financial journalist and skeptical market commentator. In today's episode, Herb talks about the evolution of markets during his career, finding and following frauds like Herbalife, and advice for those starting in markets. As we wind down, Herb explains his new business venture, Wall Street Beats, an online investment media platform. (1:05) Introducing Herb Greenberg (1:29) Herb's early career (7:10) Market structure changes during his career (11:46) Herb's five simple lessons and their modern interpretations (17:58) The role of short sellers (23:00) Herb's investigation into Herbalife (31:10) Overview of Wall Street Beats (41:17) Herb's contrarian investment beliefs ----- Follow Meb on Twitter, LinkedIn and YouTube For detailed show notes, click here To learn more about our funds and follow us, subscribe to our mailing list or visit us at cambriainvestments.com ----- Sponsor: 10 East is a membership-based investment firm founded by Michael Leffell, former Deputy Executive Managing Member of Davidson Kempner, focused on providing targeted exposure to private markets. Members invest at their discretion in single-investment and niche fund vehicles across private credit, real estate, private equity, and venture capital. Follow The Idea Farm: Twitter | LinkedIn | Instagram | TikTok ----- Interested in sponsoring the show? Email us at Feedback@TheMebFaberShow.com ----- Past guests include Ed Thorp, Richard Thaler, Jeremy Grantham, Joel Greenblatt, Campbell Harvey, Ivy Zelman, Kathryn Kaminski, Jason Calacanis, Whitney Baker, Aswath Damodaran, Howard Marks, Tom Barton, and many more.  ----- Meb's invested in some awesome startups that have passed along discounts to our listeners. Check them out here!  Learn more about your ad choices. Visit megaphone.fm/adchoices

Friday's show a with some additional info at the front and back, namely women's tennis qualifying for the ITA Kickoff event for a second straight year, and some softball news. In between Darek has plenty including USF Hall of Famer Evelyne Viens being tabbed an Olympian for a second time (5-minute mark), more international news with Jose Fernandez and the U18 national team rolling into the Americup quarterfinals (8:00), and "schedule sleuthing" as Darek compiles the AAC women's soccer and volleyball announced schedules, giving a pretty strong indication of the Bulls until theirs get officially announced (17:00).

Sharks. Sleuthing. Stories. OH MY! Ellyn brought Rachel on this episode to play a game of riddles. The two see who are super sleuths and ask each other riddles to solve. Listen along to see if you can figure out the answer for yourself. Plus, you won't want to miss Ellyn sharing all about shark movies. She's made it a mission of hers to watch as many shark movies as possible this summer, starting with Sharks Under Paris. A movie she claims is a "must-watch."  There are so many great books coming out this week, including Same As It Ever Was by Claire Lombardo, who will be joining us for Cocktails and Convos on Thursday, July 11, at 7 PM.  What we're drinking | Cocktails from Della Viti! Ellyn's Currently Reading: The Inheritance Games by Jennifer Lynn Barnes Rachel's Currently Reading: The Frame-Up by Gwenda Bond Books coming out this week: The Midnight Feast by Lucy Foley Middle of the Night by Riley Sager The Art of Catching Feelings by Alicia Thompson Same As It Ever Was by Claire Lombardo Fun Things Happening: Get your ticket for Chloe Angyal at Dog-Eared Books: HERE Get your ticket for Claire Lombardo at Dog-Eared Books: HERE ______________________________________________________________________ Make sure to subscribe and rate the Bubbles & Books Podcast. And don't forget to share it with your friends. Learn more about a Dog-Eared Books book subscription HERE. Follow us on Instagram: @bubblesandbookspodcast Follow Dog-Eared Books on Instagram: @dogearedbooksames Interested in audiobooks? Listen while supporting Dog-Eared Books HERE. Visit us! www.dogearedbooksames.com

Your ancestors were tribal, thus a drive to fit in is primally woven into your DNA.  But what happens when you want to relate to someone but it's not working out as planned?  Trying to relate to those in your family and social circles can often provoke a cortisol spike. Relating drama can be the source of a lot of elevated cortisol and stress situations. As a cultural anthropologist Dr. Jonathan Marion has studied the art of relating in various cultures and is bringing his expertise to this episode of the health fix, which is the second podcast of a two part interview series.  Not only is Dr. Jonathan Marion a cultural anthropologist, he's also an author, speaker and health coach. In this episode we'll be talking about the art of relating to others and how to view rejection in a different light.    What You'll Learn In This Episode: Why relationships are actually a practice in relating Interpreting rejection as not being a fit vs something about you as a person How relating is based on meeting each other's needs Signs your attachment style is preventing you from creating a stable and fulfilling connection  Resources From The Show: Steps Along The Way Global Steps to Chat 

TSMC is taking on Arizona. How's it going? To discuss, ChinaTalk interviewed Viola Zhou, journalist at Rest of World. She has published pieces on Foxconn's quest to make iPhones in India and most recently, a gripping feature about the cultural challenges that TSMC is facing trying to manufacture semiconductors in the USA. Throughout her story, we get a peek into a world of rigid hierarchies, American workers who are slow on the uptake, and culture clash over pornographic desktop flair.  Today's interview discusses: Sleuthing techniques for independent journalism; The challenges faced by Taiwanese semiconductor engineers relocating to Arizona; TSMC's management style and the complaints raised by new American employees; The similarities and differences between TSMC's expansion to the USA and Foxconn's expansion to India; Whether adapting to American work culture will tank the prospects of the new Phoenix Fab. Learn more about your ad choices. Visit megaphone.fm/adchoices

TSMC is taking on Arizona. How's it going? To discuss, ChinaTalk interviewed Viola Zhou, journalist at Rest of World. She has published pieces on Foxconn's quest to make iPhones in India and most recently, a gripping feature about the cultural challenges that TSMC is facing trying to manufacture semiconductors in the USA. Throughout her story, we get a peek into a world of rigid hierarchies, American workers who are slow on the uptake, and culture clash over pornographic desktop flair.  Today's interview discusses: Sleuthing techniques for independent journalism; The challenges faced by Taiwanese semiconductor engineers relocating to Arizona; TSMC's management style and the complaints raised by new American employees; The similarities and differences between TSMC's expansion to the USA and Foxconn's expansion to India; Whether adapting to American work culture will tank the prospects of the new Phoenix Fab. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Hamish realises that if the show continues to call out confectionary related fails, then they should also celebrate all the chocolate heroes out there. Andy really struggles with giving advice to Bec, so gives Hamish & Jack a chance to prove their boyfriend capabilities. A local radio show is stealing segments from the podcast, Hamish has a car based game with his kids, and the listeners return to Upset Andy again.  1. Chocolate heroes 2. Boyfriend simulator 3. Upset Andy 4. Hamish's Sandstorm blowhole game 5. Segment Sleuth - Jack rips off Song Sleuth 

Whenever there is an unsolved mystery or murder that grabs the attention of the nation, it also leads to a lot of crazies coming out of the woodwork. It's one thing to follow a case and talk about it on a forum with strangers or friends, it's a whole different thing when you start inserting yourself in the case.Let's dive in and take a look.(commercial at 10:48)to contact me:bobbycapucci@protonmail.comsource:https://www.nbcnews.com/news/us-news/internet-sleuthing-unsolved-university-idaho-slayings-can-extremely-da-rcna59406

From the archives: 12-1-22Whenever there is an unsolved mystery or murder that grabs the attention of the nation, it also leads to a lot of crazies coming out of the woodwork. It's one thing to follow a case and talk about it on a forum with strangers or friends, it's a whole different thing when you start inserting yourself in the case.Let's dive in and take a look.(commercial at 13:57)to contact me:bobbycapucci@protonmail.comsource:https://www.nbcnews.com/news/us-news/internet-sleuthing-unsolved-university-idaho-slayings-can-extremely-da-rcna59406

In a room full of heroes - Dan Hanzus, Marc Sessler, and Colleen Wolfe take a deep dive into the top ten picks of the NFL Draft to uncover the truth. Before the the sleuthing begins, the heroes react to news from around the league including the NFL's new hybrid kickoff (08:44), penalties around the hip-drop tackle (17:05), L'Jarius Sneed getting a deal with the Titans (22:45), NFL games being played on Christmas (40:13), and more! Then, the top-ten NFL Draft picks are investigated starting with the Bears (45:08) followed by picks two through ten.  Note: time codes approximate.See omnystudio.com/listener for privacy information.

USA TODAY National Correspondent Will Carless looks at an Air Force Academy plan to monitor online extremism.The Justice Department sues Apple.USA TODAY Health Reporter Karen Weintraub explains the medical significance of the first-ever kidney transplant from a gene-edited pig.The U.S. fails to crack the top 20 in the World Happiness Report.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Grab a pint, don your green, and enjoy a trio of St. Patrick's Day old time radio mysteries. First, Basil Rathbone and Nigel Bruce investigate a murder at one of Ireland's landmarks in "The Adventure of the Blarney Stone" from The New Adventures of Sherlock Holmes (originally aired on Mutual on March 18, 1946). Then, George Valentine tries to prevent a spectral eviction in "The Ghost of Ireland Betty" from Let George Do It (originally aired on Mutual on September 27, 1954). Finally, Paladin comes to the aid of an Irishman accused of robbery and murder in "Irish Luck" (originally aired on CBS on April 24, 1960).

Are you ready to put your sleuthing skills to the test? Join us for an exhilarating journey through a brand new riddles marathon! Whether you're a seasoned solver or just dipping your toes into the world of brain teasers, this is the perfect opportunity to sharpen your wits and have a blast while doing it. With a diverse array of mind-bending riddles waiting to be cracked, there's something here for everyone to enjoy. Don't miss out—join us for the ultimate riddles marathon and see if you have what it takes to emerge victorious! #brightside Animation is created by Bright Side. ---------------------------------------------------------------------------------------- Music from TheSoul Sound: https://thesoul-sound.com/ Listen to Bright Side on: Spotify - https://open.spotify.com/show/0hUkPxD... Apple Podcast - https://podcasts.apple.com/podcast/id... ---------------------------------------------------------------------------------------- Our Social Media: Facebook -   / brightside   Instagram -   / brightside.official   Tik Tok - https://www.tiktok.com/@brightside.of... Snapchat -   / 1866144599336960   Stock materials (photos, footages and other): https://www.depositphotos.com https://www.shutterstock.com https://www.eastnews.ru ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me Learn more about your ad choices. Visit megaphone.fm/adchoices

A Grave Robbery (A Veronica Speedwell Mystery) by Deanna Raybourn https://amzn.to/3UTjvxl Veronica and Stoker discover that not all fairy tales have happy endings, and some end in murder, in this latest historical mystery from New York Times bestselling and Edgar Award–nominated author Deanna Raybourn. Lord Rosemorran has purchased a wax figure of a beautiful reclining woman and asks Stoker to incorporate a clockwork mechanism to give the Rosemorran Collection its own Sleeping Beauty in the style of Madame Tussaud's. But when Stoker goes to cut the mannequin open to insert the mechanism, he makes a gruesome discovery: this is no wax figure. The mannequin is the beautifully preserved body of a young woman who was once very much alive. But who would do such a dreadful thing, and why? Sleuthing out the answer to this question sets Veronica and Stoker on their wildest adventure yet. From the underground laboratories of scientists experimenting with electricity to resurrect the dead in the vein of Frankenstein to the traveling show where Stoker once toured as an attraction, the gaslit atmosphere of London in October is the perfect setting for this investigation into the unknown. Through it all, the intrepid pair is always one step behind the latest villain—a man who has killed once and will stop at nothing to recover the body of the woman he loved. Will they unmask him in time to save his next victim? Or will they become the latest figures to be immortalized in his collection of horrors? About the author New York Times and USA Today bestselling novelist Deanna Raybourn is a 6th-generation native Texan. She graduated with a double major in English and history from the University of Texas at San Antonio. Married to her college sweetheart and the mother of one, Raybourn makes her home in Virginia. Her novels have been nominated for numerous awards including the Edgar, two RT Reviewers' Choice awards, the Agatha, two Dilys Winns, and a Last Laugh. She launched a new Victorian mystery series with the 2015 release of A CURIOUS BEGINNING, featuring intrepid butterfly-hunter and amateur sleuth, Veronica Speedwell. Veronica's second adventure is A PERILOUS UNDERTAKING (January 2017), and book three, A TREACHEROUS CURSE, was published in 2018 and nominated for the Edgar Award. A DANGEROUS COLLABORATION was released in 2019, and A MURDEROUS RELATION appeared in 2020 and AN UNEXPECTED PERIL published in March 2021. The latest Veronica Speedwell adventure, AN IMPOSSIBLE IMPOSTOR, will be published in February, 2022. Deanna's first contemporary novel featuring four female assassins who must band together to take out their nemesis as they prepare for retirement, KILLERS OF A CERTAIN AGE, will be published in September of 2022.

Weekend Edition for February 24-25. 2024 Show Notes: Support 1517 1517 Podcasts The 1517 Podcast Network on Apple Podcasts 1517 on Youtube What's New from 1517: Remembering Rod Rosenbladt New 1517 Academy Course: The Early Church: Christ, Controversies and Characters with Bruce Hillman Preorder: Encouragement for Motherhood Edited by Katie Koplin Preorder: Be Thou My Song by Kerri Tom Here We Still Stand 2023 Videos are Available on YouTube Last Chance: NWA Conference May 3rd-4th More from the hosts: Dan van Voorhis SHOW TRANSCRIPTS are available: https://www.1517.org/podcasts/the-christian-history-almanac CONTACT: CHA@1517.org SUBSCRIBE: Apple Podcasts Spotify Stitcher Overcast Google Play FOLLOW US: Facebook Twitter Audio production by Christopher Gillespie (gillespie.media).

An internet sleuth, sometimes referred to as an online detective or digital investigator, is an individual who uses online resources, such as social media platforms, forums, and publicly available information, to investigate and analyze various events or mysteries. They are known for their ability to gather information, connect dots, and sometimes even solve cases from the comfort of their own homes.Here's what they're known for:Crowdsourcing Information: Internet sleuths often rely on the collective wisdom and resources of online communities to gather information. They may ask questions, share leads, and collaborate with others to piece together details of a case.Analyzing Digital Footprints: These sleuths are skilled at tracing digital footprints left behind by individuals involved in a case. This can include analyzing social media posts, online communications, and other digital breadcrumbs to uncover relevant information.Identifying Patterns and Connections: Internet sleuths excel at identifying patterns and connections that may not be immediately apparent to others. By analyzing disparate pieces of information, they can often uncover correlations and insights that can aid in an investigation.However, there are concerns surrounding the behavior of internet sleuths:Misinformation and False Accusations: Without proper training or oversight, internet sleuths may jump to conclusions or misinterpret information, leading to false accusations or misinformation being spread online.Privacy Violations: Internet sleuths may inadvertently or intentionally violate the privacy of individuals who are not directly involved in a case. This can include doxxing (publishing private or identifying information) or harassing innocent parties.Interference with Official Investigations: In some cases, the activities of internet sleuths may interfere with official investigations by compromising evidence or tipping off suspects. Law enforcement agencies may discourage or actively work to counteract the efforts of amateur investigators for this reason.Ethical Concerns: Internet sleuths may face ethical dilemmas when navigating issues such as invasion of privacy, victimization of vulnerable individuals, or the spread of sensitive information without proper consent.While internet sleuths can sometimes provide valuable assistance to law enforcement or uncover important information in cases, it's essential for them to approach their activities with caution, integrity, and respect for privacy and legal boundaries.In this episode we take a look at the new streaming docuseries on Paramount #cybersleuths. (commercial at 12:09)to contact me:bobbycapucci@protonmail.comsource:The Delusional #CyberSleuths Trying to Solve Idaho Murders (thedailybeast.com)

An internet sleuth, sometimes referred to as an online detective or digital investigator, is an individual who uses online resources, such as social media platforms, forums, and publicly available information, to investigate and analyze various events or mysteries. They are known for their ability to gather information, connect dots, and sometimes even solve cases from the comfort of their own homes.Here's what they're known for:Crowdsourcing Information: Internet sleuths often rely on the collective wisdom and resources of online communities to gather information. They may ask questions, share leads, and collaborate with others to piece together details of a case.Analyzing Digital Footprints: These sleuths are skilled at tracing digital footprints left behind by individuals involved in a case. This can include analyzing social media posts, online communications, and other digital breadcrumbs to uncover relevant information.Identifying Patterns and Connections: Internet sleuths excel at identifying patterns and connections that may not be immediately apparent to others. By analyzing disparate pieces of information, they can often uncover correlations and insights that can aid in an investigation.However, there are concerns surrounding the behavior of internet sleuths:Misinformation and False Accusations: Without proper training or oversight, internet sleuths may jump to conclusions or misinterpret information, leading to false accusations or misinformation being spread online.Privacy Violations: Internet sleuths may inadvertently or intentionally violate the privacy of individuals who are not directly involved in a case. This can include doxxing (publishing private or identifying information) or harassing innocent parties.Interference with Official Investigations: In some cases, the activities of internet sleuths may interfere with official investigations by compromising evidence or tipping off suspects. Law enforcement agencies may discourage or actively work to counteract the efforts of amateur investigators for this reason.Ethical Concerns: Internet sleuths may face ethical dilemmas when navigating issues such as invasion of privacy, victimization of vulnerable individuals, or the spread of sensitive information without proper consent.While internet sleuths can sometimes provide valuable assistance to law enforcement or uncover important information in cases, it's essential for them to approach their activities with caution, integrity, and respect for privacy and legal boundaries.In this episode we take a look at the new streaming docuseries on Paramount #cybersleuths. (commercial at 12:09)to contact me:bobbycapucci@protonmail.comsource:The Delusional #CyberSleuths Trying to Solve Idaho Murders (thedailybeast.com)

Starting Five02 Podcast is presented by Mr & Mrs BourbonLegendary Louisville Cardinal Russ Smith is changing the bourbon game one pour at at time. Get your hands on a bottle today! https://mrandmrsbourbon.com/On this episode of the Starting Five02 Podcast brought to you by Mr and Mrs Bourbon, Pres and Jake turn up the heat on an inevitable coaching search.Sleuthing for BBH... What do we know? What do we need to know? Why does Pres care so damn much?UofL is like Groundhog DayDo the comebacks mean anything?Who is the most feasible bball coach out there?Jake's top 10 coaches revealedWhat coach is the best recruiterWhy recruiting to UofL should be cakeWhy portal recruiting takes priorityUnderrate and overrated "candidates" + much more Subscribe or Mick Cronin is the next head coach!Stock Your Bar or Grab a Draft Beer at Frankfort Avenue Liquors & WineFeaturing a full bar with award winning mixologists along with a packaged store featuring over 600 whiskeys, some of the best local brews,and much more. Visit them today at 2115 Frankfort Ave, Louisville, KY 40206 - Right next to Manhattan Project or visit https://louisvilledrinks.com/The State of Louisville Podcast Network is powered by Kern's KornerVisit Kern's Korner in The Highlands for the cities best burger & chili! Follow them on Facebook!https://www.facebook.com/kernskorner/Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

I've always wondered how learning about people online affects our in-person relationship with them. It's a fascinating question that humans have recently had to answer. This episode will raise an eyebrow and leave you thinking about how you navigate your online social life. And it turns out that there is actually some big impacts with how we navigate getting to know people in-person and online. This was a fun episode. I used visual aids (that sorta failed while simultaneously panning out), I used the whiteboard, and I referenced anecdotes. Support me on Patreon here: https://www.patreon.com/talktopeoplepodcastSign up to the Social Fitness Lab newsletter here: https://socialfitnesslab.beehiiv.com/subscribeHere's the book Together by Dr. Vivek Murthy: https://www.amazon.com/Together-Healing-Connection-Sometimes-Lonely/dp/0062913301/ref=sr_1_1?crid=1D34WN34ZT4YS&keywords=together&qid=1705295295&sprefix=together%2Caps%2C112&sr=8-1Look at the GQ article I mentioned here: https://www.gq.com/story/sharing-is-not-caringHappy January!An easy way to send me a message? Click the link here.Have you enjoyed the podcast? If so, follow it, rate it, and share it with three people: Follow on Apple Podcasts Follow on Spotify Follow on Instagram Subscribe on YouTube If you want to share feedback, have a great idea, or have a question then email me: talktopeoplepodcast@gmail.comProduced by Capture Connection Studios: captureconnectionstudios.com

It's Q&A time! We're back, answering YOUR burning questions! Are we ALL pre-date sleuthing one another online, and should you mention what you found to your date? If you're dating someone "perfect", what does it mean when you keep thinking about your ex? And if someone who routinely got in car accidents asked to borrow your new car, what would you say? Come join us in our living room for the Shandy take! Thanks to our sponsors! - Go to https://www.rocketmoney.com/SHANDY to save money and cancel unwanted subscriptions the easy way! - Go to https://www.lomi.com/SHANDY and use promo code SHANDY at checkout to save $50! - Go to https://www.skims.com and get free shipping on orders over $75! - Go to https://hellofresh.com/SHANDYFREE and use code SHANDYFREE for free breakfast for life! Time Stamps: 0:00 - Q1: My Pre-Date Googling Revealed Something About My Date—Should I Bring It Up With Him? 12:33 - Q2: My Grandmother Has Passed But Wanted Me To Have Her Wedding Ring—How Do I Bring This Up With Family? 24:23 - Q3: My Boyfriend Is Perfect But I Keep Thinking About My Ex—Help! 39:50 - Q4: We've Gone From Friends To Dating To Friends Again—Shandy's Take? 56:30 - Q5: My Boyfriend Sucks At Driving And Wants To Borrow My New Car 1:06:55 - Announcements If you have a relationship question, write us at: dearshandy@gmail.com Subscribe and watch the episodes on YouTube! https://bit.ly/SubscribeDearShandy Follow us! Dear Shandy - https://www.instagram.com/dearshandy Sharleen Joynt - https://www.instagram.com/sharleenjoynt Andy Levine - https://www.instagram.com/machinelevine Privacy & Opt-Out: https://redcircle.com/privacy Support this podcast at — https://redcircle.com/dear-shandy/donations Learn more about your ad choices. Visit megaphone.fm/adchoices

Gather 'round for another episode of Constellation, Last Stand Media's conversational podcast. Joining the Brothers Moriarty this week is LSM's coordinator and shopkeep Micah Watson, alongside Sacred Symbols co-host Chris Ray Gun. Dagan gets us started by asking us each to pitch a new video game to the audience, and naturally delivers a delightful idea of his own as well. Micah's nail person recently moved shops, and that presents a problem: She has no idea what salon she's defected to. She's turned to internet sleuthing to solve the case. Chris wants to chat about breakups and how they present themselves in our lives. Sometimes they're our choice; other times we're blindsided by them. What memories come to mind when the topic comes up? Finally, Colin ends with something silly: The humble egg. Fresh off an 'argument' between he and Micah about how eggs should be cooked and consumed, he goes to bat for why eggs may be the best food of them all. Learn more about your ad choices. Visit podcastchoices.com/adchoices

They solve crimes and captivate our attention. Detectives on TV! Since at least the late 1930s, detectives have been a staple of television shows. Most are procedurals like the "Law & Order" contingent, a bunch are from prestige dramas a la "Sherlock," some are comedies (think "Monk" or “Brooklyn Nine-Nine”), and some are even animated ("Inspector Gadget" counts!). But regardless, there's something intrinsically fascinating about watch brilliant minds crack cases in an hour or less. And now, the Great Pop Culture Debate podcast wants to determine: Who is the Best TV Detective of all time? Join Host Eric Rezsnyak, GPCD panelists Amy Pilott and Kate Racculia, and special guest Josh Duggan from the Munch My Benson podcast as they discuss 16 of the most iconic detectives from television past and present. To listen to Round 1, showing how we got to the Sleuthing 16 down from the Top 32, become a Patreon supporter of the podcast today to access the exclusive Part 1 episode. EPISODE CREDITS Host: Eric Rezsnyak Panel: Amy Pilott, Kate Racculia Special Guest: Josh Duggan Producer: Curtis Creekmore Editor: Jeffery Perry Learn more about your ad choices. Visit megaphone.fm/adchoices

Courtney does some cyber sleuthing over alleged Belichick video

This week,  Landon and Jeremiah run through a grab bag of Austin FC roster news, rumors, and speculation. They also answer some listener questions. Other topics and questions include:- Nick Lima trade updates- Finlay renewal official- Cryptic Instagram messages- Not so cryptic Instagram messages- What we learned from Dani on Estamos Ready- Would you take Chicharito or Josef?- 11 Jon Gallaghers vs 11 Julio Cascantes- Free ticket giveaway- moreRemember to rate, review, and subscribe to the show at moontowersoccer.com or via your favorite podcasting app.This episode is brought to you by FVF LawSupport the show

The supernatural and the rational come together in the murder mystery. Thank you to my returning guest, Carla Valentine, for joining me. She is a trained mortuary technician and the technical curator at Barts Pathology Museum in London. She's also the author of Murder Isn't Easy: The Forensics of Agatha Christie. This episode marks the beginning of the 2023 Shedunnit Pledge Drive! Help ensure the future of the podcast and get your hands on some exclusive audio perks by becoming a Shedunnit member now at shedunnitshow.com/pledgedrive. Mentioned in this episode: — The Murders in the Rue Morgue by Edgar Allan Poe — The Moonstone by Wilkie Collins — The Hound of the Baskervilles by Arthur Conan Doyle — Hallowe'en Party by Agatha Christie — The Four Just Men by Edgar Wallace — The Pale Horse by Agatha Christie — The Halloween Murders by John Newton Chance — Wraiths and Changelings by Gladys Mitchell — Calendar of Crime by Ellery Queen — The Crime at Black Dudley by Margery Allingham — The Plague Court Murders by John Dickson Carr — The Red Widow Murders by John Dickson Carr — Footsteps in the Dark by Georgette Heyer — When Last I Died by Gladys Mitchell — Murder is Easy by Agatha Christie — The Unicorn Murders by John Dickson Carr — A Corpse at Camp Two by Glyn Carr — He Who Whispers by John Dickson Carr — The Spirit Murder Mystery by Robin Forsythe — Look to the Lady by Margery Allingham Related Shedunnit episodes: — Knock Knock — Murder Isn't Easy — The Golden Age Autopsy NB: Links to Blackwell's are affiliate links, meaning that the podcast receives a small commission when you purchase a book there (the price remains the same for you). Blackwell's is a UK bookselling chain that ships internationally at no extra charge. Become a member of the Shedunnit book club and get bonus audio, listen to ad free episodes and join a book-loving community at shedunnitshow.com/membership. To be the first to know about future developments with the podcast, sign up for the newsletter at shedunnitshow.com/newsletter. The podcast is on Twitter, Facebook, Tumblr and Instagram as @ShedunnitShow, and you can find it in all major podcast apps. Make sure you're subscribed so you don't miss the next episode. Click here to do that now in your app of choice. Find a full transcript of this episode at shedunnitshow.com/spookysleuthingtranscript. Music by Audioblocks and Blue Dot Sessions. See shedunnitshow.com/musiccredits for more details. Learn more about your ad choices. Visit megaphone.fm/adchoices

Trying to figure out your gut issues and can't seem to find a protocol that works for you?  Know you have SIBO (small intestine bowel overgrowth) and you can't seem to get it under control? Tried every cleanse, detox, kill protocol and even use pharmaceuticals and you're still struggling?  Diagnosed with Hashimoto's or celiac and looking to reverse your condition naturally? Lindsey Parsons, EdD is a Certified Health Coach and host of "The Perfect Stool: Understanding and Healing the Gut Microbiome" podcast.  In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews Lindsey Parsons on her unique approach to restoring the gut microbiome and reversing autoimmune conditions.    What You'll Learn In This Episode: How self fecal transplants can help with b12 absorption and digestion The connection between low B12, iron, ferritin, the gut microbiome and autoimmune conditions Lindsay's process of restoring her gut health to lower her Hashimoto's antibodies H Pylori infections and food poisoning and autoimmune conditions The benefit of max dosing tributyrin with each meal IBS Smart Test and the 2 antibodies it tests for IBS diarrhea types Resources From The Show: Lindsey Parsons - Website The Perfect Stool Podcast

Genetic genealogy can catch brutal killers. It can also unmask affairs, secret adoptions, and other dark secrets. As well as expose you—yes, you—to the unholy alliance of Big Tech and shady police work...Our Sponsors:* Check out Rosetta Stone and use my code TODAY for a great deal: https://www.rosettastone.com/Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This week's old time radio mysteries blend comedy with crimesolving. First, Jonathan Latimer's William Crane jumps from the page to the radio in an adaptation of his novel "Lady in the Morgue" from The Mollé Mystery Theatre (AFRS rebroadcast from "Mystery Playhouse"). Then, Albert Dekker and Mike Mazurki star as a pair of con men and reluctant detectives in Johnny Fletcher Mystery. This 1946 audition recording was adapted from Frank Gruber's novel "The Navy Colt." And finally, Nick and Nora Charles hunt for a missing dog in "The Adventure of the Passionate Palooka" from The New Adventures of the Thin Man (originally aired on NBC on July 6, 1948). Click here to watch Albert Dekker and Mike Mazurki as Johnny Fletcher and Sam Cregg in The French Key.