Podcasts about exemplifying

Rose and Doug Phillips asked: “how can we spend every day, together, doing what we love?” Their answer was Conscious Clothing. For two decades they built their business on this premise - even building the gorgeous, sun-filled Michigan studio where their team of ten designs and makes each piece of organic and natural fiber clothing.  Things haven't always been dreamy, though. As the brand grew, work started to creep into the weekends. The pandemic hit. Then Doug lost his life and business partner. But, the heartfelt vision for Conscious Clothing remained. In this interview, Doug and General Manager Liz DeBraber share how they're intentionally restructuring the business for the sake of themselves, their team, and their customers. Doug Phillips is the owner of Conscious Clothing, an organic and natural fiber clothing company based in the Grand Rapids Michigan area. While navigating the challenges of designing and manufacturing in the US for over 23 years against a flood of cheap clothing imports, a mission was born. Exemplifying how a better way is possible by supporting local and organic is better for people and the planet. Doug hopes everyone realizes their power to create change with the purchase power they have and the brands they choose to support. This episode explores: Fitting the customer How Liz is completely revamping Conscious Clothing's pattern library to better fit their customers The process behind extending their sizing from XS-XL to XS-6X.  How their small team things about customer service Fitting the lifestyle How founders Doug and Rose built the business from the ground up to realize the life they wanted together What they changed to keep the growing business from taking over their life How a years-long season of grief forced Doug to make big changes in the business Why sustainability is just as much about the lifestyle of the team than it is about the products they are making How they are balancing R&D with production Fitting the values Why organic and natural fibers and made-in-USA production are important to Conscious Clothing How the industry and consumer values about organic clothing has changed over the 20+ years they've been in business Why Doug is happy that Conscious Clothing is not as unique as it once was People and resources mentioned in this episode: Conscious Clothing website Conscious Clothing Instagram Fox fiber® - breeder and grower of organic, naturally colored cotton Do you want fashion business tips and resources like this sent straight to your inbox? Sign up for the How Fitting newsletter to receive new podcast episodes plus daily content on creating fashion that fits your customer, lifestyle, and values.

Beacon artist opens studio to beginners Not too long ago, Beacon High School offered woodworking classes in a space now occupied by Rexhill Studio. An old sign outside one of the warren of rooms in the KuBe Art Center reads: "GO4 Wood Shop." Today, students can access a Construction Trade curriculum that includes some woodworking instruction through Dutchess BOCES. Two are enrolled. Exemplifying the decline of practical manual arts education, studio co-owner Justin King attended the Oregon College of Art and Craft, which shuttered in 2019 after 112 years. To fill the instructive void, King launched an eight-week introduction to the basics, Woodshop Beacon, which sold out fast and wrapped up on Wednesday (May 21). "We have fewer places to do this kind of thing," he says. "With YouTube and other videos, you're starting in the middle and backtracking to the beginning, so this helps plug in the knowledge gap." The endgame for the class is a handmade square box, a task that requires several basic skills. A model jewel case that King created is shaped to near perfection, with seamless joints; the top tray nestles inside with zero wiggle room. Press a button in the back and out pops a hidden drawer. "Boxes can be simple, but they require time, dedication and ability," says King. The name Rexhill, incorporating the Latin word for his last name, harks to the family farm in Ohio. After making his way to Portland, he met his wife, Paula, who plays an instrumental role at the studio. The couple drifted east with stopovers because there are lots of woodworkers in the Pacific Northwest and she grew up in New Jersey. In 2006, when they settled in Beacon, "it was pretty rough," she says. "But you could feel a change in the air." Justin King's first love is fine furniture, and he makes tables and credenzas with artistic and technical flair. The studio also devises custom installations in collaboration with architects, homeowners, contractors and interior designers. For the Woodshop Beacon class, students began by "playing around with planing," according to the curriculum. They progressed to joinery and working with machines, taking advantage of hands-on shop time on Saturday mornings. Building the box requires choosing the type of wood and assembling, sanding and completing the project. "Even if a finished piece is functional, it is art because no two designs are alike," says King, who worried about filling up seats and was comforted by the response. Dylan Assael, a friend, jumped at the chance to attend. "I thought, 'How great would it be to acquire this skill and level up my abilities?' " he says. Assael also took a sewing class and creates flags that mesh with the decor at boat and yacht clubs. Though woodworking presents inherent danger, he faced his fears. "Those tools can maim and injure and that scares the shit out of me, so I'm glad to get instruction from a pro and keep my digits intact," he says. "Sifting through videos is frustrating; it's so much easier to talk to a human being and get instant feedback." Rexhill Studio is located at 211 Fishkill Ave., Suite GO1 & 4B, in Beacon. See rexhillstudio.com or call 503-490-7280.

In this episode, we have a STEMulating Conversaion with Keith Conerly, a Sr. Vice President at Compass Group USA . A chemist by training, he shares how his time at Jackson State University, an HBCU in Mississippi, and his volunteer and mentoring roles in NOBCChE shaped his leadership principles. Keith reflects on the invaluable lessons he learned during his college years—lessons that continue to guide his approach to leadership today. A firm believer in meeting people where they are, Keith emphasizes the importance of embracing the whole person in the workplace. He discusses how true leadership goes beyond professional skills, focusing on empathy, understanding, and personal growth. His leadership and mentoring philosophy is simple yet profound: If one person touches one other person, then everyone is eventually touched. Liisten in for an inspiring conversation on leadership, mentorship, and the power of human connection in driving success. Who are Keith's Chaotic Connections?  Former President Barak Obama and NBA Legend Steph Curry.

A couple years ago I was interviewed on what I believe to be the most important aspects of high-quality leadership. And here is the in-depth interview.If you enjoyed this episode, can you please help and:1. Leave a 5-star rating and review? 2. Share this with one friend?3. Support the newsletter?  https://seedsofsuccess.beehiiv.com/subscribeThank You

Funding for the NIH and US biomedical research is imperiled at a momentous time of progress. Exemplifying this is the work of Dr. Anna Greka, a leading physician-scientist at the Broad Institute who is devoted to unlocking the mysteries of rare diseases— that cumulatively affect 30 million Americans— and finding cures, science supported by the NIH.A clip from our conversationThe audio is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.Transcript with audio and external linksEric Topol (00:06):Well, hello. This is Eric Topol from Ground Truths, and I am really delighted to welcome today, Anna Greka. Anna is the president of the American Society for Clinical Investigation (ASCI) this year, a very prestigious organization, but she's also at Mass General Brigham, a nephrologist, a cell biologist, a physician-scientist, a Core Institute Member of the Broad Institute of MIT and Harvard, and serves as a member of the institute's Executive Leadership Team. So we got a lot to talk about of all these different things you do. You must be pretty darn unique, Anna, because I don't know any cell biologists, nephrologists, physician-scientist like you.Anna Greka (00:48):Oh, thank you. It's a great honor to be here and glad to chat with you, Eric.Eric Topol (00:54):Yeah. Well, I had the real pleasure to hear you speak at a November conference, the AI for Science Forum, which we'll link to your panel. Where I was in a different panel, but you spoke about your extraordinary work and it became clear that we need to get you on Ground Truths, so you can tell your story to everybody. So I thought rather than kind of going back from the past where you were in Greece and somehow migrated to Boston and all that. We're going to get to that, but you gave an amazing TED Talk and it really encapsulated one of the many phenomenal stories of your work as a molecular sleuth. So maybe if you could give us a synopsis, and of course we'll link to that so people could watch the whole talk. But I think that Mucin-1 or MUC1, as you call it, discovery is really important to kind of ground our discussion.A Mysterious Kidney Disease Unraveled Anna Greka (01:59):Oh, absolutely. Yeah, it's an interesting story. In some ways, in my TED Talk, I highlight one of the important families of this story, a family from Utah, but there's also other important families that are also part of the story. And this is also what I spoke about in London when we were together, and this is really sort of a medical mystery that initially started on the Mediterranean island of Cyprus, where it was found that there were many families in which in every generation, several members suffered and ultimately died from what at the time was a mysterious kidney disease. This was more than 30 years ago, and it was clear that there was something genetic going on, but it was impossible to identify the gene. And then even with the advent of Next-Gen sequencing, this is what's so interesting about this story, it was still hard to find the gene, which is a little surprising.Anna Greka (02:51):After we were able to sequence families and identify monogenic mutations pretty readily, this was still very resistant. And then it actually took the firepower of the Broad Institute, and it's actually from a scientific perspective, an interesting story because they had to dust off the old-fashioned Sanger sequencing in order to get this done. But they were ultimately able to identify this mutation in a VNTR region of the MUC1 gene. The Mucin-1 gene, which I call a dark corner of the human genome, it was really, it's highly repetitive, very GC-rich. So it becomes very difficult to sequence through there with Next-Gen sequencing. And so, ultimately the mutation of course was found and it's a single cytosine insertion in a stretch of cytosines that sort of causes this frameshift mutation and an early stop codon that essentially results in a neoprotein like a toxic, what I call a mangled protein that sort of accumulates inside the kidney cells.Anna Greka (03:55):And that's where my sort of adventure began. It was Eric Lander's group, who is the founding director of the Broad who discovered the mutation. And then through a conversation we had here in Boston, we sort of discovered that there was an opportunity to collaborate and so that's how I came to the Broad, and that's the beginnings of this story. I think what's fascinating about this story though, that starts in a remote Mediterranean island and then turns out to be a disease that you can find in every continent all over the world. There are probably millions of patients with kidney disease in whom we haven't recognized the existence of this mutation. What's really interesting about it though is that what we discovered is that the mangled protein that's a result of this misspelling of this mutation is ultimately captured by a family of cargo receptors, they're called the TMED cargo receptors and they end up sort of grabbing these misfolded proteins and holding onto them so tight that it's impossible for the cell to get rid of them.Anna Greka (04:55):And they become this growing heap of molecular trash, if you will, that becomes really hard to manage, and the cells ultimately die. So in the process of doing this molecular sleuthing, as I call it, we actually also identified a small molecule that actually disrupts these cargo receptors. And as I described in my TED Talk, it's a little bit like having these cargo trucks that ultimately need to go into the lysosome, the cells recycling facility. And this is exactly what this small molecule can do. And so, it was just like a remarkable story of discovery. And then I think the most exciting of all is that these cargo receptors turn out to be not only relevant to this one mangled misshapen protein, but they actually handle a completely different misshapen protein caused by a different genetic mutation in the eye, causing retinitis pigmentosa, a form of blindness, familial blindness. We're now studying familial Alzheimer's disease that's also involving these cargo receptors, and there are other mangled misshapen proteins in the liver, in the lung that we're now studying. So this becomes what I call a node, like a nodal mechanism that can be targeted for the benefit of many more patients than we had previously thought possible, which has been I think, the most satisfying part about this story of molecular sleuthing.Eric Topol (06:20):Yeah, and it's pretty extraordinary. We'll put the figure from your classic Cell paper in 2019, where you have a small molecule that targets the cargo receptor called TMED9.Anna Greka (06:34):Correct.Expanding the MissionEric Topol (06:34):And what's amazing about this, of course, is the potential to reverse this toxic protein disease. And as you say, it may have applicability well beyond this MUC1 kidney story, but rather eye disease with retinitis pigmentosa and the familial Alzheimer's and who knows what else. And what's also fascinating about this is how, as you said, there were these limited number of families with the kidney disease and then you found another one, uromodulin. So there's now, as you say, thousands of families, and that gets me to part of your sleuth work is not just hardcore science. You started an entity called the Ladders to Cures (L2C) Scientific Accelerator.Eric Topol (07:27):Maybe you can tell us about that because this is really pulling together all the forces, which includes the patient advocacy groups, and how are we going to move forward like this?Anna Greka (07:39):Absolutely. I think the goal of the Ladders to Cures Accelerator, which is a new initiative that we started at the Broad, but it really encompasses many colleagues across Boston. And now increasingly it's becoming sort of a national, we even have some international collaborations, and it's only two years that it's been in existence, so we're certainly in a growth mode. But the inspiration was really some of this molecular sleuthing work where I basically thought, well, for starters, it cannot be that there's only one molecular node, these TMED cargo receptors that we discovered there's got to be more, right? And so, there's a need to systematically go and find more nodes because obviously as anyone who works in rare genetic diseases will tell you, the problem for all of us is that we do what I call hand to hand combat. We start with the disease with one mutation, and we try to uncover the mechanism and then try to develop therapies, and that's wonderful.Anna Greka (08:33):But of course, it's slow, right? And if we consider the fact that there are 30 million patients in the United States in every state, everywhere in the country who suffer from a rare genetic disease, most of them, more than half of them are children, then we can appreciate the magnitude of the problem. Out of more than 8,000 genes that are involved in rare genetic diseases, we barely have something that looks like a therapy for maybe 500 of them. So there's a huge mismatch in the unmet need and magnitude of the problem. So the Ladders to Cures Accelerator is here to address this and to do this with the most modern tools available. And to your point, Eric, to bring patients along, not just as the recipients of whatever we discover, but also as partners in the research enterprise because it's really important to bring their perspectives and of course their partnerships in things like developing appropriate biomarkers, for example, for what we do down the road.Anna Greka (09:35):But from a fundamental scientific perspective, this is basically a project that aims to identify every opportunity for nodes, underlying all rare genetic diseases as quickly as possible. And this was one of the reasons I was there at the AI for Science Forum, because of course when one undertakes a project in which you're basically, this is what we're trying to do in the Ladders to Cures Accelerator, introduce dozens of thousands of missense and nonsense human mutations that cause genetic diseases, simultaneously introduce them into multiple human cells and then use modern scalable technology tools. Things like CRISPR screens, massively parallel CRISPR screens to try to interrogate all of these diseases in parallel, identify the nodes, and then develop of course therapeutic programs based on the discovery of these nodes. This is a massive data generation project that is much needed and in addition to the fact that it will help hopefully accelerate our approach to all rare diseases, genetic diseases. It is also a highly controlled cell perturbation dataset that will require the most modern tools in AI, not only to extract the data and understand the data of this dataset, but also because this, again, an extremely controlled, well controlled cell perturbation dataset can be used to train models, train AI models, so that in the future, and I hope this doesn't sound too futuristic, but I think that we're all aiming for that cell biologists for sure dream of this moment, I think when we can actually have in silico the opportunity to make predictions about what cell behaviors are going to look like based on a new perturbation that was not in the training set. So an experiment that hasn't yet been done on a cell, a perturbation that has not been made on a human cell, what if like a new drug, for example, or a new kind of perturbation, a new chemical perturbation, how would it affect the behavior of the cell? Can we make a predictive model for that? This doesn't exist today, but I think this is something, the cell prediction model is a big question for biology for the future. And so, I'm very energized by the opportunity to both address this problem of rare monogenic diseases that remains an unmet need and help as many patients as possible while at the same time advancing biology as much as we possibly can. So it's kind of like a win-win lifting all boats type of enterprise, hopefully.Eric Topol (12:11):Yeah. Well, there's many things to get to unpack what you've just been reviewing. So one thing for sure is that of these 8,000 monogenic diseases, they have relevance to the polygenic common diseases, of course. And then also the fact that the patient family advocates, they are great at scouring the world internet, finding more people, bringing together communities for each of these, as you point out aptly, these rare diseases cumulatively are high, very high proportion, 10% of Americans or more. So they're not so rare when you think about the overall.Anna Greka (12:52):Collectively.Help From the Virtual Cell?Eric Topol (12:53):Yeah. Now, and of course is this toxic proteinopathies, there's at least 50 of these and the point that people have been thinking until now that, oh, we found a mangled protein, but what you've zeroed in on is that, hey, you know what, it's not just a mangled protein, it's how it gets stuck in the cell and that it can't get to the lysosome to get rid of it, there's no waste system. And so, this is such fundamental work. Now that gets me to the virtual cell story, kind of what you're getting into. I just had a conversation with Charlotte Bunne and Steve Quake who published a paper in December on the virtual cell, and of course that's many years off, but of course it's a big, bold, ambitious project to be able to say, as you just summarized, if you had cells in silico and you could do perturbations in silico, and of course they were validated by actual experiments or bidirectionally the experiments, the real ones helped to validate the virtual cell, but then you could get a true acceleration of your understanding of cell biology, your field of course.Anna Greka (14:09):Exactly.Eric Topol (14:12):So what you described, is it the same as a virtual cell? Is it kind of a precursor to it? How do you conceive this because this is such a complex, I mean it's a fundamental unit of life, but it's also so much more complex than a protein or an RNA because not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions. So this is a bold challenge, right?Anna Greka (14:41):Oh my god, it's absolutely from a biologist perspective, it's the challenge of a generation for sure. We think taking humans to Mars, I mean that's an aspirational sort of big ambitious goal. I think this is the, if you will, the Mars shot for biology, being able to, whether the terminology, whether you call it a virtual cell. I like the idea of saying that to state it as a problem, the way that people who think about it from a mathematics perspective for example, would think about it. I think stating it as the cell prediction problem appeals to me because it actually forces us biologists to think about setting up the way that we would do these cell perturbation data sets, the way we would generate them to set them up to serve predictions. So for example, the way that I would think about this would be can I in the future have so much information about how cell perturbations work that I can train a model so that it can predict when I show it a picture of another cell under different conditions that it hasn't seen before, that it can still tell me, ah, this is a neuron in which you perturbed the mitochondria, for example, and now this is sort of the outcome that you would expect to see.Anna Greka (16:08):And so, to be able to have this ability to have a model that can have the ability to predict in silico what cells would look like after perturbation, I think that's sort of the way that I think about this problem. It is very far away from anything that exists today. But I think that the beginning starts, and this is one of the unique things about my institute, if I can say, we have a place where cell biologists, geneticists, mathematicians, machine learning experts, we all come together in the same place to really think and grapple with these problems. And of course we're very outward facing, interacting with scientists all across the world as well. But there's this sort of idea of bringing people into one institute where we can just think creatively about these big aspirational problems that we want to solve. I think this is one of the unique things about the ecosystem at the Broad Institute, which I'm proud to be a part of, and it is this kind of out of the box thinking that will hopefully get us to generate the kinds of data sets that will serve the needs of building these kinds of models with predictive capabilities down the road.Anna Greka (17:19):But as you astutely said, AlphaFold of course was based on the protein database existing, right? And that was a wealth of available information in which one could train models that would ultimately be predictive, as we have seen this miracle that Demi Hassabis and John Jumper have given to humanity, if you will.Anna Greka (17:42):But as Demis and John would also say, I believe is as I have discussed with them, in fact, the cell prediction problem is really a bigger problem because we do not have a protein data bank to go to right now, but we need to create it to generate these data. And so, my Ladders to Cures Accelerator is here to basically provide some part of the answer to that problem, create this kind of well-controlled database that we need for cell perturbations, while at the same time maximizing our learnings about these fully penetrant coding mutations and what their downstream sequelae would be in many different human cells. And so, in this way, I think we can both advance our knowledge about these monogenic diseases, build models, hopefully with predictive capabilities. And to your point, a lot of what we will learn about this biology, if we think that it involves 8,000 or more out of the 20,000 genes in our genome, it will of course serve our understanding of polygenic diseases ultimately as well as we go deeper into this biology and we look at the combinatorial aspects of what different mutations do to human cells. And so, it's a huge aspirational problem for a whole generation, but it's a good one to work on, I would say.Learning the Language of Life with A.I. Eric Topol (19:01):Oh, absolutely. Now I think you already mentioned something that's quite, well, two things from what you just touched on. One of course, how vital it is to have this inner or transdisciplinary capability because you do need expertise across these vital areas. But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that, but it's not. Of course, as you mentioned, we have genome editing which allows to look at lots of different genome perturbations, like the single letter change that you found in MUC1 pathogenic critical mutation. There's also the AI world which is blossoming like I've never seen. In fact, I had in Science this week about learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human cell.Eric Topol (20:14):So this is exploding. As you said, the expertise in computer science and then this whole idea that you could take these powerful tools and do as you said, which is the need to accelerate, we just can't sit around here when there's so much discovery work to be done with the scalability, even though it might take years to get to this artificial intelligence virtual cell, which I have to agree, everyone in biology would say that's the holy grail. And as you remember at our conference in London, Demi Hassabis said that's what we'd like to do now. So it has the attention of leaders in AI around the world, obviously in the science and the biomedical community like you and many others. So it is an extraordinary time where we just can't sit still with these tools that we have, right?Anna Greka (21:15):Absolutely. And I think this is going to be, you mentioned the ASCI presidency in the beginning of our call. This is going to be the president gets to give an address at the annual meeting in Chicago. This is going to be one of the points I make, no matter what field in biomedicine we're in, we live in, I believe, a golden era and we have so many tools available to us that we can really accelerate our ability to help more patients. And of course, this is our mandate, the most important stakeholders for everything that we do as physician-scientists are our patients ultimately. So I feel very hopeful for the future and our ability to use these tools and to really make good on the promise of research is a public good. And I really hope that we can advance our knowledge for the benefit of all. And this is really an exciting time, I think, to be in this field and hopefully for the younger colleagues a time to really get excited about getting in there and getting involved and asking the big questions.Career ReflectionsEric Topol (22:21):Well, you are the prototype for this and an inspiration to everyone really, I'm sure to your lab group, which you highlighted in the TED Talk and many other things that you do. Now I want to spend a little bit of time about your career. I think it's fascinating that you grew up in Greece and your father's a nephrologist and your mother's a pathologist. So you had two physicians to model, but I guess you decided to go after nephrology, which is an area in medicine that I kind of liken it to Rodney Dangerfield, he doesn't get any respect. You don't see many people that go into nephrology. But before we get to your decision to do that somehow or other you came from Greece to Harvard for your undergrad. How did you make that connect to start your college education? And then subsequently you of course you stayed in Boston, you've never left Boston, I think.Anna Greka (23:24):I never left. Yeah, this is coming into 31 years now in Boston.Anna Greka (23:29):Yeah, I started as a Harvard undergraduate and I'm now a full professor. It's kind of a long, but wonderful road. Well, actually I would credit my parents. You mentioned that my father, they're both physician-scientists. My father is now both retired, but my father is a nephrologist, and my mother is a pathologist, actually, they were both academics. And so, when we were very young, we lived in England when my parents were doing postdoctoral work. That was actually a wonderful gift that they gave me because I became bilingual. It was a very young age, and so that allowed me to have this advantage of being fluent in English. And then when we moved back to Greece where I grew up, I went to an American school. And from that time, this is actually an interesting story in itself. I'm very proud of this school.Anna Greka (24:22):It's called Anatolia, and it was founded by American missionaries from Williams College a long time ago, 150 and more years ago. But it is in Thessaloniki, Greece, which is my hometown, and it's a wonderful institution, which gave me a lot of gifts as well, preparing me for coming to college in the United States. And of course, I was a good student in high school, but what really was catalytic was that I was lucky enough to get a scholarship to go to Harvard. And that was really, you could say the catalyst that propelled me from a teenager who was dreaming about a career as a physician-scientist because I certainly was for as far back as I remember in fact. But then to make that a reality, I found myself on the Harvard campus initially for college, and then I was in the combined Harvard-MIT program for my MD PhD. And then I trained in Boston at Mass General in Brigham, and then sort of started my academic career. And that sort of brings us to today, but it is an unlikely story and one that I feel still very lucky and blessed to have had these opportunities. So for sure, it's been wonderful.Eric Topol (25:35):We're the ones lucky that you came here and set up shop and you did your productivity and discovery work and sleuthing has been incredible. But I do think it's interesting too, because when you did your PhD, it was in neuroscience.Anna Greka (25:52):Ah, yes. That's another.Eric Topol (25:54):And then you switch gears. So tell us about that?Anna Greka (25:57):This is interesting, and actually I encourage more colleagues to think about it this way. So I have always been driven by the science, and I think that it seems a little backward to some people, but I did my PhD in neuroscience because I was interested in understanding something about these ion channels that were newly discovered at the time, and they were most highly expressed in the brain. So here I was doing work in the brain in the neuroscience program at Harvard, but then once I completed my PhD and I was in the middle of my residency training actually at Mass General, I distinctly remember that there was a paper that came out that implicated the same family of ion channels that I had spent my time understanding in the brain. It turned out to be a channelopathy that causes kidney disease.Anna Greka (26:43):So that was the light bulb, and it made me realize that maybe what I really wanted to do is just follow this thread. And my scientific curiosity basically led me into studying the kidney and then it seemed practical therefore to get done with my clinical training as efficiently as possible. So I finished residency, I did nephrology training, and then there I was in the lab trying to understand the biology around this channelopathy. And that sort of led us into the early projects in my young lab. And in fact, it's interesting we didn't talk about that work, but that work in itself actually has made it all the way to phase II trials in patients. This was a paper we published in Science in 2017 and follow onto that work, there was an opportunity to build this into a real drug targeting one of these ion channels that has made it into phase II trials. And we'll see what happens next. But it's this idea of following your scientific curiosity, which I also talked about in my TED Talk, because you don't know to what wonderful places it will lead you. And quite interestingly now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye in brain. So I tell people, do not limit yourself to whatever someone says your field is or should be. Just follow your scientific curiosity and usually that takes you to a lot more interesting places. And so, that's certainly been a theme from my career, I would say.Eric Topol (28:14):No, I think that's perfect. Curiosity driven science is not the term. You often hear hypothesis driven or now with AI you hear more AI exploratory science. But no, that's great. Now I want to get a little back to the AI story because it's so fascinating. You use lots of different types of AI such as cellular imaging would be fusion models and drug discovery. I mean, you've had drug discovery for different pathways. You mentioned of course the ion channel and then also as we touched on with your Cell paper, the whole idea of targeting the cargo receptor with a small molecule and then things in between. You discussed this of course at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state-of-the-art science that you're doing?Anna Greka (29:17):Sure, yeah, thank you. I think there are many ways in which even for quite a long time before AI became such a well-known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time. And so, this is actually a form of AI that we use in order to process millions of images. My lab has by produced probably more than 20 million images over the last few years, maybe five to six years. And so, if you can imagine it's impossible for any human to process this many images and make sense of them. So of course, we've been using machine learning that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.Anna Greka (30:06):And so, there's multiple different kinds of perturbations that we do to cells, whether we're using CRISPR or base editing to make, for example, genome wide or genome scale perturbations or small molecules as we have done as well in the past. These are all ways in which we are then using machine learning to read out the effects in images of cells that we're looking at. So that's one way in which machine learning is used in our daily work, of course, because we study misshape and mangled proteins and how they are recognized by these cargo receptors. We also use AlphaFold pretty much every day in my lab. And this has been catalytic for us as a tool because we really are able to accelerate our discoveries in ways that were even just three or four years ago, completely impossible. So it's been incredible to see how the young people in my lab are just so excited to use these tools and they're becoming extremely savvy in using these tools.Anna Greka (31:06):Of course, this is a new generation of scientists, and so we use AlphaFold all the time. And this also has a lot of implications of course for some of the interventions that we might think about. So where in this cargo receptor complex that we study for example, might we be able to fit a drug that would disrupt the complex and lead the cargo tracks into the lysosome for degradation, for example. So there's many ways in which AI can be used for all of these functions. So I would say that if we were to organize our thinking around it, one way to think about the use of machine learning AI is around what I would call understanding biology in cells and what in sort of more kind of drug discovery terms you would call target identification, trying to understand the things that we might want to intervene on in order to have a benefit for disease.Anna Greka (31:59):So target ID is one area in which I think machine learning and AI will have a catalytic effect as they already are. The other of course, is in the actual development of the appropriate drugs in a rational way. So rational drug design is incredibly enabled by AlphaFold and all these advances in terms of understanding protein structures and how to fit drugs into them of all different modalities and kinds. And I think an area that we are not yet harnessing in my group, but I think the Ladders to Cures Accelerator hopes to build on is really patient data. I think that there's a lot of opportunity for AI to be used to make sense of medical records for example and how we extract information that would tell us that this cohort of patients is a better cohort to enroll in your trial versus another. There are many ways in which we can make use of these tools. Not all of them are there yet, but I think it's an exciting time for being involved in this kind of work.Eric Topol (32:58):Oh, no question. Now it must be tough when you know the mechanism of these families disease and you even have a drug candidate, but that it takes so long to go from that to helping these families. And what are your thoughts about that, I mean, are you thinking also about genome editing for some of these diseases or are you thinking to go through the route of here's a small molecule, here's the tox data in animal models and here's phase I and on and on. Where do you think because when you know so much and then these people are suffering, how do you bridge that gap?Anna Greka (33:39):Yeah, I think that's an excellent question. Of course, having patients as our partners in our research is incredible as a way for us to understand the disease, to build biomarkers, but it is also exactly creating this kind of emotional conflict, if you will, because of course, to me, honesty is the best policy, if you will. And so, I'm always very honest with patients and their families. I welcome them to the lab so they can see just how long it takes to get some of these things done. Even today with all the tools that we have, of course there are certain things that are still quite slow to do. And even if you have a perfect drug that looks like it fits into the right pocket, there may still be some toxicity, there may be other setbacks. And so, I try to be very honest with patients about the road that we're on. The small molecule path for the toxic proteinopathies is on its way now.Anna Greka (34:34):It's partnered with a pharmaceutical company, so it's on its way hopefully to patients. Of course, again, this is an unpredictable road. Things can happen as you very well know, but I'm at least glad that it's sort of making its way there. But to your point, and I'm in an institute where CRISPR was discovered, and base editing and prime editing were discovered by my colleagues here. So we are in fact looking at every other modality that could help with these diseases. We have several hurdles to overcome because in contrast to the liver and the brain, the kidney for example, is not an organ in which you can easily deliver nucleic acid therapies, but we're making progress. I have a whole subgroup within the bigger group who's focusing on this. It's actually organized in a way where they're running kind of independently from the cell biology group that I run.Anna Greka (35:31):And it's headed by a person who came from industry so that she has the opportunity to really drive the project the way that it would be run milestone driven, if you will, in a way that it would be run as a therapeutics program. And we're really trying to go after all kinds of different nucleic acid therapies that would target the mutations themselves rather than the cargo receptors. And so, there's ASO and siRNA technologies and then also actual gene editing technologies that we are investigating. But I would say that some of them are closer than others. And again, to your question about patients, I tell them honestly when a project looks to be more promising, and I also tell them when a project looks to have hurdles and that it will take long and that sometimes I just don't know how long it will take before we can get there. The only thing that I can promise patients in any of our projects, whether it's Alzheimer's, blindness, kidney disease, all I can promise is that we're working the hardest we possibly can on the problem.Anna Greka (36:34):And I think that is often reassuring I have found to patients, and it's best to be honest about the fact that these things take a long time, but I do think that they find it reassuring that someone is on it essentially, and that there will be some progress as we move forward. And we've made progress in the very first discovery that came out of my lab. As I mentioned to you, we've made it all the way to phase II trials. So I have seen the trajectory be realized, and I'm eager to make it happen again and again as many times as I can within my career to help as many people as possible.The Paucity of Physician-ScientistsEric Topol (37:13):I have no doubts that you'll be doing this many times in your career. No, there's no question about it. It's extraordinary actually. There's a couple of things there I want to pick up on. Physician-scientists, as you know, are a rarefied species. And you have actually so nicely told the story about when you have a physician-scientist, you're caring for the patients that you're researching, which is, most of the time we have scientists. Nothing wrong with them of course, but you have this hinge point, which is really important because you're really hearing the stories and experiencing the patients and as you say, communicating about the likelihood of being able to come up with a treatment or the progress. What are we going to do to get more physician-scientists? Because this is a huge problem, it has been for decades, but the numbers just keep going lower and lower.Anna Greka (38:15):I think you're absolutely right. And this is again, something that in my leadership of the ASCI I have made sort of a cornerstone of our efforts. I think that it has been well-documented as a problem. I think that the pressures of modern clinical care are really antithetical to the needs of research, protected time to really be able to think and be creative and even have the funding available to be able to pursue one's program. I think those pressures are becoming so heavy for investigators that many of them kind of choose one or the other route most often the clinical route because that tends to be, of course where they can support their families better. And so, this has been kind of the conundrum in some ways that we take our best and brightest medical students who are interested in investigation, we train them and invest in them in becoming physician-scientists, but then we sort of drop them at the most vulnerable time, which is usually after one completes their clinical and scientific training.Anna Greka (39:24):And they're embarking on early phases of one's careers. It has been found to be a very vulnerable point when a lot of people are now in their mid-thirties or even late thirties perhaps with some family to take care of other burdens of adulthood, if you will. And I think what it becomes very difficult to sustain a career where one salary is very limited due to the research component. And so, I think we have to invest in our youngest people, and it is a real issue that there's no good mechanism to do that at the present time. So I was actually really hoping that there would be an opportunity with leadership at the NIH to really think about this. It's also been discussed at the level of the National Academy of Medicine where I had some role in discussing the recent report that they put out on the biomedical enterprise in the United States. And it's kind of interesting to see that there is a note made there about this issue and the fact that there needs to be, I think, more generous investment in the careers of a few select physician-scientists that we can support. So if you look at the numbers, currently out of the entire physician workforce, a physician-scientist comprised of less than 1%.Anna Greka (40:45):It's probably closer to 0.8% at this point.Eric Topol (40:46):No, it's incredible.Anna Greka (40:48):So that's really not enough, I think, to maintain the enterprise and if you will, this incredible innovation economy that the United States has had this miracle engine, if you will, in biomedicine that has been fueled in large part by physician investigators. Of course, our colleagues who are non-physician investigators are equally important partners in this journey. But we do need a few of the physician-scientists investigators I think as well, if you really think about the fact that I think 70% of people who run R&D programs in all the big pharmaceutical companies are physician-scientists. And so, we need people like us to be able to work on these big problems. And so, more investment, I think that the government, the NIH has a role to play there of course. And this is important from both an economic perspective, a competition perspective with other nations around the world who are actually heavily investing in the physician-scientist workforce.Anna Greka (41:51):And I think it's also important to do so through our smaller scale efforts at the ASCI. So one of the things that I have been involved in as a council member and now as president is the creation of an awards program for those early career investigators. So we call them the Emerging-Generation Awards, and we also have the Young Physician-Scientist Awards. And these are really to recognize people who are making that transition from being kind of a trainee and a postdoc and have finished their clinical training into becoming an independent assistant professor. And so, those are small awards, but they're kind of a symbolic tap on the shoulder, if you will, that the ASCI sees you, you're talented, stay the course. We want you to become a future member. Don't give up and please keep on fighting. I think that can take us only so far.Anna Greka (42:45):I mean, unless there's a real investment, of course still it will be hard to maintain people in the pipeline. But this is just one way in which we have tried to, these programs that the ASCI offers have been very successful over the last few years. We create a cohort of investigators who are clearly recognized by members of the ASCI is being promising young colleagues. And we give them longitudinal training as part of a cohort where they learn about how to write a grant, how to write a paper, leadership skills, how to run a lab. And they're sort of like a buddy system as well. So they know that they're in it together rather than feeling isolated and struggling to get their careers going. And so, we've seen a lot of success. One way that we measure that is conversion into an ASCI membership. And so, we're encouraged by that, and we hope that the program can continue. And of course, as president, I'm going to be fundraising for that as well, it's part of the role. But it is a really worthy cause because to your point, we have to somehow make sure that our younger colleagues stay the course that we can at least maintain, if not bolster our numbers within the scientific workforce.Eric Topol (43:57):Well, you outlined some really nice strategies and plans. It's a formidable challenge, of course. And we'd like to see billions of dollars to support this. And maybe someday we will because as you say, if we could relieve the financial concerns of people who have curiosity driven ideas.Anna Greka (44:18):Exactly.Eric Topol (44:19):We could do a lot to replenish and build a big physician-scientist workforce. Now, the last thing I want to get to, is you have great communication skills. Obviously, anybody who is listening or watching this.Eric Topol (44:36):Which is another really important part of being a scientist, no less a physician or the hybrid of the two. But I wanted to just go to the backstory because your TED Talk, which has been watched by hundreds of thousands of people, and I'm sure there's hundreds of thousands more that will watch it, but the TED organization is famous for making people come to the place a week ahead. This is Vancouver used to be in LA or Los Angeles area and making them rehearse the talk, rehearse, rehearse, rehearse, which seems crazy. You could train the people there, how to give a talk. Did you have to go through that?Anna Greka (45:21):Not really. I did rehearse once on stage before I actually delivered the talk live. And I was very encouraged by the fact that the TED folks who are of course very well calibrated, said just like that. It's great, just like that.Eric Topol (45:37):That says a lot because a lot of people that do these talks, they have to do it 10 times. So that kind of was another metric. But what I don't like about that is it just because these people almost have to memorize their talks from giving it so much and all this coaching, it comes across kind of stilted and unnatural, and you're just a natural great communicator added to all your other things.Anna Greka (46:03):I think it's interesting. Actually, I would say, if I may, that I credit, of course, I actually think that it's important, for us physician-scientists, again, science and research is a public good, and being able to communicate to the public what it is that we do, I think is kind of an obligation for the fact that we are funded by the public to do this kind of work. And so, I think that's important. And I always wanted to cultivate those communication skills for the benefit of communicating simply and clearly what it is that we do in our labs. But also, I would say as part of my story, I mentioned that I had the opportunity to attend a special school growing up in Greece, Anatolia, which was an American school. One of the interesting things about that is that there was an oratory competition.Anna Greka (46:50):I got very early exposure entering that competition. And if you won the first prize, it was in the kind of ancient Rome way, first among equals, right? And so, that was the prize. And I was lucky to have this early exposure. This is when I was 14, 15, 16 years old, that I was training to give these oratory speeches in front of an audience and sort of compete with other kids who were doing the same. I think these are just wonderful gifts that a school can give a student that have stayed with me for life. And I think that that's a wonderful, yeah, I credit that experience for a lot of my subsequent capabilities in this area.Eric Topol (47:40):Oh, that's fantastic. Well, this has been such an enjoyable conversation, Anna. Did I miss anything that we need to bring up, or do you think we have it covered?Anna Greka (47:50):Not at all. No, this was wonderful, and I thoroughly enjoyed it as well. I'm very honored seeing how many other incredible colleagues you've had on the show. It's just a great honor to be a part of this. So thank you for having me.Eric Topol (48:05):Well, you really are such a great inspiration to all of us in the biomedical community, and we'll be cheering for your continued success and thanks so much for joining today, and I look forward to the next time we get a chance to visit.Anna Greka (48:20):Absolutely. Thank you, Eric.**************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding and support for biomedical research at NIH and other US governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Talk or type with our new Team Bot: https://realestateteamos.com/botTop-line revenue growth of a real estate team is great. But driving that growth while preserving your gross profit margin and net profit margin is even better.In this conversation, Anthwon Thomas shares his numbers along with the story of starting and growing Silver Lining Real Estate Group brokered by Real in Lafayette, Indiana.Learn the key elements to preserving profit as you grow, including clarity on your operating model and equity in commission splits. Hear which roles they hired and in what order. Get their three-stage process for bringing great-fit people onto the team. Watch or listen to this conversation with Anthwon Thomas for insights into: - Exemplifying the values and principles of the team as a leader and as a leadership team- Dropping out of a pre-law university path and becoming a real estate agent- When and why he started a team with someone who's still a member today (and the “scary” part of the process)- Which staff and agents they hired and in what order- Growing production 50% with a new CRM, a database manager, and more accountability- Their main lead sources and their monthly ad spend- How onboarding and training have evolved over the past 7 years- Why he abandoned the idea of a NAVY Seal team in favor of recruiting more agents- The three minimum standards required from every agent on the team (20, 20, and Tuesday)- Details of their three-stage process to find people who fit their operating model (group call, one-way video interview, one-on-one meeting)- Why a 60% gross profit margin and 25% net profit margin are their goals- Why the key to preserving profit margin is managing your cost of sale / commission split- Why he started the High Value Agent podcastAt the end, learn about Team Thomas masterminds, G-Wagon anxiety, and the benefits of writing. Episode Mentions:- Episode 022 with Matt Smith https://www.realestateteamos.com/episode/real-estate-team-leader-leadership-lessons-matt-smith- FUBCON Session with Jon Cheplak https://www.realestateteamos.com/episode/jon-cheplak-real-estate-teams-traditional-brokerages- Episode 009 with Daniel Dixon https://www.realestateteamos.com/episode/daniel-dixon-lighthouse-real-estate-agentsAnthwon Thomas:- https://www.instagram.com/anthwonthomas/- https://www.facebook.com/AnthwonThomas/High Value Agent:- https://www.instagram.com/highvalueagent/- https://www.facebook.com/groups/858436428634711- https://highvalueagent.com/hva/Silver Lining Real Estate Group:- https://www.slreg.com/about/- https://www.instagram.com/_slreg_/- https://www.facebook.com/SLREG/Book Recommendation:- The Power of a Positive Team by John GordonReal Estate Team OS:- https://www.realestateteamos.com- https://linktr.ee/realestateteamos- https://www.instagram.com/realestateteamos/ Talk or type with our new Team Bot: https://realestateteamos.com/bot

On the 27th and 28th of November, Hexagon Manufacturing Intelligence invited MTD magazine to the official opening of its new Experience Centre in Holland. Located at the Brainport Industries Campus in the Northwest of Eindhoven, the two-day event was an opportunity to tour the new campus and participate in insightful presentations that demonstrated how Hexagon is driving innovation and, as a result, developing successful industrial partnerships. Eindhoven is responsible for the Philishave, the automatic gearbox, the cassette tape and the compact disc. To foster this culture of innovation for future generations, the Dutch government funded the Brainport Industries Campus, which broke ground in 2017. At around 100,000sq/m, the innovation centre is virtually fully subscribed, and that is why construction of a 225,000sq/m phase two on the 17-hectare site will commence this year. With dozens of high-tech businesses collaborating at the campus, Hexagon is alongside cutting-edge companies with brands like Siemens and Meta (Facebook), just a few located at the facility. MTD magazine attended and the itinerary for the innovation extravaganza promised an exciting lineup. The event started with a welcome from Jan Klingen, Vice President EMEA North, and Eric Veurink, Brainport Industries Campus Director, and a facility tour. As expected with a Hexagon LIVE event, the breadth and depth of technology and insights were so expansive that delegates could choose the most relevant content for their business. Exemplifying this was one of the first panel discussions on the ‘Future of Mobility in Aerospace and Automotive', hosted by Hexagon Senior Director for Industry Solutions, Johannes Mann, who was joined by speakers Rob van Loon, Additive Manufacturing Manager at KMWE and Thom Grobben, the Vice President of the Technology Hub at KLM Royal Dutch Airlines. The discussion flowed through the challenges of accelerating innovation and agility in the automotive sector to deliver the next generation of smart, connected vehicles. This conversation then moved on to the aerospace industry's challenges in redefining aircraft architecture and propulsion systems to become more sustainable. Other prominent seminars discussed ‘The challenges in production and collaboration', ‘Extending asset lifecycles and improving productivity with HxGN EAM', ‘Surfing the future now' and ‘Innovation beyond silos: Transforming Manufacturing through connectivity, collaboration, and Cloud/AI'. There was a lot more on show, with panel discussions, presentations, workshops and roundtable debates encompassing every industry sector. Nowhere was this more prominent than in Morgan Maia's presentation, the Partnership Manager at Oracle Red Bull Racing. Hexagon has partnered with the F1 team since its inception. Flying in from the F1 Teams' weekend win in Las Vegas, Morgan discussed how Hexagon supports the team in streamlining performance by ensuring compliance with FIA regulations, precision manufacturing, and ensuring the team ‘gets it right first time'. More than just a soundbite, Mike Hughes, Head of Quality Assurance and Manufacturing Engineering at Oracle Red Bull Racing, qualified the support of Hexagon with a statement: “With Hexagon's help, we've managed to reduce our faults by 50% over the last two years.” Morgan's presentation alluded to how Hexagon is involved throughout the process chain, from 3D CAD modelling and CFD simulations in the virtual wind tunnel to simulation and physical wind tunnel testing. With over one million components handled throughout the season, Oracle Red Bull Racing combines exceptional hardware with efficient software and digital twins to deliver rapid inspection rates. The team has four QA departments encompassing mechanical, external, composites, and race support. They all utilise Hexagon tools, from CAM software to 3D scanners, laser trackers, portable measuring arms and CMMs. The Leica AT960 scanner is a core element of the trackside equipment that improves accuracy and holistic measurement. Its custom orientation enables measurement from different perspectives. For legality checks, Oracle Red Bull Racing uses the AS1 scanner to scan the floor, front, and rear wings to extract key points of the car for performance set-up. With the arrival of Red Bull's first road car, the RB17, and the opening of its 5,000sq/ft powertrain manufacturing site in Milton Keynes, Red Bull's number of components produced is set to expand significantly, as will its relationship with Hexagon. The F1 car continually undergoes design cycles that follow the same structured path. With up to 100 projects in-cycle at any time, around 1,000 design cycles are completed yearly. It starts with developing a 3D CAD model and the subsequent digital twin, which is the foundation block for everything that comes after. With CFD, prototypes and a whole raft of processes before the team gets to a finished car, Morgan said: “When you work on a car in the factory and then take it to the track, if there is an issue in manufacturing – it's too late to do anything about it. We must be sure the car is 100% correct before shipping it. That is why we need Hexagon: to ensure that everything leaving the factory is perfect for when it arrives at the track. We have thousands of parts that need to fit together perfectly. We work to the micron. It's precision you would see in a high-end watch – but not typically in a 5m long vehicle.” A presentation on Hexagon's Nexus suite by Stephen Graham, Executive Vice President and GM of Nexus at Hexagon, followed this. Stephen explained: “Nexus is our cloud-based manufacturing platform. We initially conceived it to solve an internal problem. We have acquired over 150 companies in more than 25 years, which has helped us build this portfolio of technologies throughout the product life-cycle. Our challenge is a large portfolio of technology solutions that were never really intended to work together. We wanted to offer our customers a solution to join the dots and bring the next level of value with the technologies all being under one roof. Nexus was conceived to solve this problem of connectivity. As soon as we took the proposition to our customers, we found they had the same problem. Over decades, they had purchased different technologies to solve different problems.” “Nexus directly solves that problem, and what we have found in the last few months is an ability to connect to different technologies from different vendors - it doesn't just have to be Hexagon products. Since starting development, we have found that businesses are structured very hierarchically, with different disciplines arranged in different silos. The whole thing is very process-driven, and as we try to push the boundaries of manufacturing, this becomes a barrier to succeeding. The need to drive collaboration horizontally across an organisation is coming to the fore as a challenge that needs to be faced.” To demonstrate this, Stephen provided a slide show showing a reverse-engineered workflow using 10 products from Hexagon that facilitate different elements of a product's lifecycle. The demonstration alluded to new cloud-native apps, technologies and solutions connected to products in the portfolio for decades, such as PC-DMIS. Nexus creates an end-to-end solution that connects the dots. Stephen added: “Once these collaborative workflows have been strung together, engineers can work collaboratively. This provides the opportunity to bring automated and AI technologies into the workflow as automated collaborators in the workflow. A great example of this is ProPlanAI, which we just launched. This large NAPA language model provides precise engineering answers for CAM engineers who may be programming CNC machines. It automatically collates data and generates a G-Code to drive machines on the shop floor. This gives engineers superpowers to drive productivity to the next level.” Hexagon claims that ProPlan AI cuts the time to program machine tools by 75%. The new AI technology enables machine shops to achieve operational excellence at scale, powered by Microsoft Azure services built into Hexagon's cloud-based Nexus connectivity platform. Available in Q1 2025, ProPlanAI will ‘learn' from the data created by a company's CAM programmers. This will enable manufacturers to automatically explore existing programming information to predict ideal outcomes tailored to a company's preferences, production capabilities, and needs. ProPlanAI will continuously learn and adapt, ensuring programs are as efficient and productive as possible. ProPlanAI can be trained with a company's institutional knowledge to ensure machines can be quickly and efficiently programmed to their quality standards. Additionally, a Hexagon Copilot provides suggested pathways to advise on best practices without leaving their CAM software. The innovation has been developed in collaboration with Microsoft, and Ygal Levy, the EMEA Manufacturing Managing Director at Microsoft, discussed the company's strategic partnership with Hexagon in greater detail during an afternoon presentation on the ‘Transformation of manufacturing through Connectivity, Collaboration and Cloud/AI'. Clare Barclay, President of Enterprise and Industry at Microsoft EMEA, said: “Microsoft's collaboration with Hexagon is driven by a shared belief that we can transform manufacturing productivity. It's rewarding for us to see how the AI capabilities provided by Azure are empowering CNC programmers with productivity-boosting automation while helping new users upskill faster. This is exactly the sort of transformation AI can bring to the industry, and we are excited to see Hexagon apply its manufacturing expertise to transform workplace productivity.” Verifying the Solution Just over a year ago, MTD magazine visited RODIN Machining. A few miles north of Amsterdam, the start-up company set out to develop an autonomous factory. Incorporating FASTEMS automation, robot-loaded Mazak machines, and integrated innovations that made the mind boggle, RODIN has been a beta-test customer, putting ProPlanAI through its paces before market introduction. Paul Mooij, Director of Digital at RODIN Machining, said: “Machine tool programming is complicated to automate and requires experience. ProPlanAI is exciting because we can leverage our human capital for greater machine utilisation. Our team can program machines in a fraction of the time by applying their valued skills in supervising ProPlanAI suggestions and finalising the programme specifics.”  Paul added: “We have built an autonomous factory but are limited by the engineering input we can put into it. This boils down to a race for talent, and we all know it isn't easy to get good people. We have been working with Hexagon on the development of ProPlanAI, looking at how can we fill it with our data and train it with our models, our machines, tools and our way of working - providing a suggestion of how the model thinks our way of working should be. We can then position our engineer to supervise and undertake ‘prompt engineering'. ProPlanAI is very powerful and provides the right context for the features, model, machines, and tooling available. Using the given context, it then decides, ‘I think you should use these processes for this machining operation''.” “This has become powerful, and we are progressing rapidly to make big savings. We are leveraging our human capital to achieve more by using AI to provide suggestions. Then, our engineers decide whether to accept the suggestion and proceed or refine the process. For example, we may have a 2D PDF drawing that needs to meet specific tolerances, and ProPlanAI may not know this – and this is the experience we can add to the system. It's been a fantastic collaboration, and the system continually evolves.” Discussing the current situation, Paul told MTD magazine: “Our engineers will consider how they approach a job and create the CAM file in Esprit. We then feed our models to our developers. Over the last 18 months, we have been feeding the data to ProPlan AI, which uses our approach, machining strategies, cutting tools, machines, characteristics and experience. ProPlan AI creates suggestions for the next job and pre-populates our program, so our engineers are validating and refining the suggestions to meet our specifications. It amplifies the output of our staff.” “For example, if we have an aluminium job that needs a threaded hole with a chamfer, we would have a unique way of doing that with our machines and tools in our CAM files. Based on those patterns, the model learns our strategies and recognises the parameters for a threaded hole in aluminium, the feeds, speeds and so on.” Looking at benefits during testing, Paul adds: “It is amplifying our output and boosting our efficiency. At present, the savings are impressive. We continuously add data to our ProPlanAI suite, so the savings will cascade into ever greater efficiencies as we progress.”

Sermon Summary: It is often said that it's now how you start but how you finish that matters. For Christianity, it's not how you start but that you finish that matters in the end. Only those who finish will be saved in the judgment, and it is this doctrine of perseverance with which we are called to wrestle in this text.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, January 12, 2025

What does an award-winning technology strategy look like? Find out as we highlight two of the most recent winners of Forrester's Technology Strategy Impact Award, Best Buy and First Student.

Sermon Summary: The Christians we read about in the New Testament immersed themselves in the life of the church and labored diligently to make disciples of Jesus. For them, it was more than a willingness to participate in gospel ministry; the very heart was oriented toward it. Few lives demonstrate this heart for discipling as Paul's, and his testimony in these verses gives us a glimpse of what it looks like to truly have a heart for gospel work.     Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, January 5, 2025

In this episode of Balanced Warrior, we are joined by special guest Mike Regina, a serial entrepreneur who embodies the philosophy of multidimensional success. Mike successfully manages multiple businesses, oversees a team of over 40 employees, nurtures a nearly 25-year marriage, and prioritizes time for his three children, regular exercise, meditation, prayer, and giving back to his community.   Key Takeaways:   1. **Confidence and Enthusiasm**: Approach projects and businesses with confidence and excitement.   2. **Failure as a Stepping Stone**: View failure as a temporary setback on the path to success. Embrace fearlessness in the face of defeat.   3. **Building with the Right People**: Surround yourself with the right individuals as the foundation of any successful venture. Collaboration is key; great things are seldom achieved alone.   4. **Golden Rule**: Treat others with respect and love as you would want to be treated. Maintain a culture of mutual regard.   5. **Leading by Example**: As a leader, demonstrate that no task is above or below you. Lead with humility and responsibility.   6. **Creating a Positive Work Culture**: Focus on creating a work environment where your team looks forward to Mondays.   7. **Non-Negotiables for Team Members**:    - Be a proactive problem solver.    - Cultivate confidence in your abilities.    - Demonstrate emotional intelligence and self-control.    - Take ownership and fix mistakes promptly.    - Embrace failure as a learning opportunity for personal growth and improvement.   Tune in to this insightful episode of Balanced Warrior as Mike Regina shares his expertise on achieving success across various facets of life while embodying the principles of balance, leadership, and personal growth.

Sermon Summary: While the Thessalonians Christians represent those who, upon receiving the gospel–the Word of God–accept it, the unbelieving Jews represent those who continually reject it. This passage is a warning for those who refuse the gospel, and it is a reminder of the immense value of Christ to those who accept it and suffer for it.     Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, December 8, 2024

Sermon Summary: As he reflects on the miraculous conversion and perseverance of the Thessalonian Christians, Paul highlights the Spirit's work through the ministry of the Word of God–the preaching of the gospel of Jesus. This text teaches us that the Word of God works to save sinners and strengthen saints.    Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, December 1, 2024

Sermon Summary: One of the most difficult things to do in life is discerning who you can truly trust. Unfortunately, we are often betrayed by those whom we should be able to trust the most, including spiritual leaders. But is there a way to identify Christian ministers who are trustworthy? The Scriptures give us the criteria for such discernment, and this text is one that helps us understand the nature of authentic ministry.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, November 24, 2024

Sermon Summary: As in most places that he visited, it seems that enemies of the gospel in Thessalonica accused Paul of some improprieties in his ministry there. Though the Christians knew better and weren't persuaded, Paul still felt it necessary for their sake and the gospel's to defend the faithfulness of his ministry. The result is an incredibly helpful model of faithful ministry for us to follow.    Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, November 3, 2024

Sermon Summary: What comes to your mind when you consider the most important qualities of an individual in gospel ministry? In 1 Thessalonians 2:7-8, Paul described his ministry to the Thessalonians in ways that are often missing in many Christians today.    Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, November 10, 2024

Sermon Summary: Shockwaves of gospel impact were felt all over Macedonia and Achaia, and the epicenter of it all was the embattled congregation in Thessalonica. In this text, we learn that there is no limit to how God can use a faithful church, but the only church God uses is one that is rooted and grounded in the gospel of Jesus Christ.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, October 27, 2024

Who's someone you admire for his or her character? John and Danny share examples of people they appreciate for their character qualities. Then, Jim Daly and Dr. Kathy Koch talk about learning from the character of Jesus, and why He's the perfect example for our kids to emulate.   Find us online at focusonthefamily.com/parentingpodcast. Or call 1-800-A-FAMILY.   Receive the book Parenting Differently for your donation of any amount!   Take the 7 Traits of Effective Parenting Assessment   Listen Anytime   Age and Stage eNewsletters   Teaching Character to Your Kids   Support This Show!   If you've listened to any of our podcasts, please give us your feedback.

Who's someone you admire for his or her character? John and Danny share examples of people they appreciate for their character qualities. Then, Jim Daly and Dr. Kathy Koch talk about learning from the character of Jesus, and why He's the perfect example for our kids to emulate.   Find us online at focusonthefamily.com/parentingpodcast. Or call 1-800-A-FAMILY.   Receive the book Parenting Differently for your donation of any amount!   Take the 7 Traits of Effective Parenting Assessment   Listen Anytime   Age and Stage eNewsletters   Teaching Character to Your Kids   Support This Show!   If you've listened to any of our podcasts, please give us your feedback. To support this ministry financially, visit: https://www.oneplace.com/donate/1197/29

Sermon Summary: Though they may have been disdained and persecuted by their unbelieving neighbors, Paul was certain that the Thessalonian Christians were loved and chosen by God. But how could he be so sure? In this text, there are two proofs of God's electing love that will either be for you a line in the sand that exposes your actual standing with God or a tremendous encouragement and strength to your heart.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, October 20, 2024

Sermon Summary: In their opening thanksgiving, Paul, Silas, and Timothy underscored a triad of Christian virtues that are repeated throughout the New Testament: Faith, Love, and Hope. These three virtues are distinct perspectives of a person's genuine conversion to Jesus Christ, and they are all a work of grace accomplished by God.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, October 13, 2024

Sermon Summary: Though the opening greeting of Paul's first letter to the Thessalonians follows a typical structure for a letter of that day, it is teeming with gospel meaning. This study examines the three parts of 1 Thessalonians 1:1 and traces the history of the start of the Thessalonian Church (Acts 17:1-10) to expose the church's gospel beginnings, gospel identity, and gospel hope.   Series Summary: Called the "Cinderella Epistles of the New Testament" by some, 1-2 Thessalonians are an often overlooked treasure of gospel hope for those who follow Jesus. Despite intense persecution, the Church of the Thessalonians persevered in the faith, longing for the day that Jesus returns to deliver his people and judge the wicked. Exemplifying the unique and genuine bond that arises through a shared faith and struggle, the Apostle Paul wrote to remind the beleaguered Thessalonians of their hope in Christ and to instruct them on how to carry on until he comes. Join us as we study these divinely inspired letters!   Preached on Sunday, October 6, 2024

Philippians Principle 7 – Exemplifying the IncarnationTo demonstrate to the world who Jesus Christ is we are to work out our salvation.Support the show

Storytelling is critical, especially when you want to succeed in business. Not only does it humanise you, but it allows for people to connect with your brand in ways slogans, marketing and logos can't. Think about it: what is more interesting, a company's ‘About Us' page or the founder's personal journey to founding it? In this episode, Joel Hines will help you craft your best communication and storytelling skills yet. Joel is a facilitator, TEDx speaker, author, trainer and storyteller. Throughout a career spanning over 25 years working in mental health, IT, training, educational leadership and group facilitation, there has been a common theme of guiding others to explore the shared experience of being human. In that time, he was also the school principal at a school based on Buddhist philosophies, and talks about how that manifested in the day-to-day of managing the school - both for teachers and for students. Exemplifying integrity and authenticity, Joel motivates and enables leaders to cultivate engagement, foster collaboration and empower others. His natural gift for storytelling, combined with his calm and approachable demeanour, fuels his passion for enriching workplace connections and fostering the growth of facilitation skills and confidence.–Follow The Founder Tapes on Instagram, TikTok and LinkedInSubscribe to The Founder Tapes on YouTube! –Find Joel Hines on LinkedIn Find Being Human on LinkedIn or visit https://www.beinghuman.net.au/ Find Joel's book here: Holding Space: Strategies To Cultivate Connection and Enable Potential Watch Joel's TEDx speech here: https://youtu.be/-QpGJNtuYZo?si=rHYdEqgxD3Izg5l5 –Music License Number - QK7rZS Hosted on Acast. See acast.com/privacy for more information.

Faith That Passes the Test Exemplifying Faith Hebrews 11 JULY 28 2024

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An elder must be “above reproach” 1 Timothy 3:2. 2 Corinthians 6:3 — We put no stumbling block in anyone's path, so that our ministry will not be discredited. The post 6/9/24 — Exemplifying Godly Character appeared first on Eugene Church of Christ.

“If you only had two hours a day to work, what is the highest and best use of your value, relevance, and impact in that two hours?”In this episode, Rebecca shares a powerful coaching session she had with a client who experienced profound adversity. The episode explores the importance of intentional presence in leadership, the long-term perspective in decision-making, and the value of self-awareness and regulating one's nervous system. Listen in to discover practical insights for achieving greater clarity, impact, and personal growth in your life and business.In this episode, you'll learn:Explore how being fully present in your leadership role can positively impact your decision-making, communication, and overall effectivenessGain a deeper understanding of the value of taking a long-term view when making decisions in both life and businessDiscover self-awareness's significance and understanding of your nervous system responses in navigating challenges and adversityThings to listen for:[09:11] Unveiling true self-awareness[11:03] The journey towards self-awareness and human connection[16:52] Mastering self-regulation to unleash the power of your nervous systemResources:Learn more about Rebecca and her workGet your copy of Write Your Own StoryListen to Rebecca's Audiobook Write Your Own StoryTake the Badass QuizConnect with Rebecca:https://www.linkedin.com/in/rebeccafleetwoodhession/https://www.instagram.com/rebeccafleetwoodhession/https://www.facebook.com/fleetwoodhession/https://www.tiktok.com/@rebeccafleetwoodhession

In this captivating episode of Spoodcast, join your hosts Lauren and Laena with special guest Victor, an exotic pet proprietor and respected expositor. Victor shares his intriguing journey from a dinosaur admirer to becoming a specialist in tarantula breeding and management, while also revealing his broad experiences from attending various expos worldwide. Engaging and knowledgeable, Victor dispels common misconceptions about Old World tarantulas and provides insightful comparisons between New World and Old World tarantula species. He also shares insightful, often humorous anecdotes from his experiences handling peculiar creatures, offering a in-depth look into the exotic pet trade. Born and raised in Brazil, Victor discusses his life's journey – from interacting with local fauna, moving to the United States, and establishing a successful business in the exotic pet industry. He also discusses the contrasts between American and Brazilian fauna and shines a light on their respective pet industry regulations. This immersive discussion digs into unexpected venomous potential of certain animals, debunks popular myths about spiders, and is filled to the brim with intriguing animal facts and captivating anecdotes. From scorpion threats to a painful encounter with an octopus, Victor offers listeners a candid, riveting peek into his life and career. Exemplifying both passion and dedication, Victor provides honest insights into the challenging, yet rewarding world of tarantula breeding while shedding light on the overlooked aspects of the pet trade industry. With invaluable tips and tricks on handling tarantula emergencies, managing egg sacs, and feeding slings, the episode is a treasure trove of arachnid knowledge.

We had the pleasure of interviewing Matisyahu over Zoom video!The Grammy-nominated singer, songwriter, and alternative reggae rock musician Matisyahu recently release his new EP, Hold The Fire, via his own label Fallen Sparks Records.In his continued support of his Jewish roots, Matisyahu, who has never shied away from speaking his mind about current topics, his religion, and the history of the Jewish people, is also using his platform to speak out about the current war in Israel. He recently made a surprise appearance at the March for Israel in Washington, DC performing his global anthem “One Day” with The Maccabeats, a standout moment for the hundreds of thousands who gathered and watched, and also recently performed for and spoke at Columbia University to uplift the students amidst the rise of antisemitism on college campuses.Matisyahu has always used his music, which is rooted in the heritage of the Jewish people, as a source of empowerment and strength. “Fireproof” is another testament to that with its timely and hopeful message that is resonating with listening everywhere and has even been hailed as “an anthem of overcoming adversity.” “Fireproof” touches upon Matisyahu's unwavering ability to keep his artistic fire burning while exploring the topics of perseverance and gratitude in times of trouble, a theme everyone can relate to. The new single stems from a dream Matisyahu had about holding the fire, which became a metaphor for him as an artist and as a Jew and serves as the inspiration for the EP's title and theme. While the new EP is centered around the four earth elements, Matisyahu also reflects on celebrity and artistic success and the observation that we often find ourselves imitating other people or listening too much to their opinions of us, as he explores in “Fool's Gold.” For nearly two decades, Matisyahu has kept his creative spirit aflame by evolving his sound, melding genres, and testing the limits of the musical traditions that have inspired him. A special kind of fire spurred the creation of Hold The Fire.About Matisyahu:Like only the most gifted storytellers, Matisyahu spins the rare kind of stories that simultaneously enlighten, enthrall, and expand the audience's sense of possibility. Known for his skill in blending a shapeshifting collision of reggae, hip-hop, alt rock and boldly inventive pop – all while paying homage to his spirituality and roots in Judaism – Matisyahu's live shows consistently provide audiences with a dynamic and energetic performance full of life and illumination. With nearly 20 years under his belt, he's teamed up with the best improvisational musicians and artists for jam sessions and collaborations, and his long and winding career consists of seven studio albums including the chart-topping Light (2009), Youth (2006), and Spark Seeker (2012), as well as Akeda (2014), Undercurrent (2017), and Matisyahu (2022), and various live albums including his 2005 Gold-certified breakthrough Live At Stubb's. This past summer, the New York-raised and New Jersey-based multi-talent released Live In Brooklyn, recorded at the iconic Brooklyn Bowl New York during his annual Festival of Light. Exemplifying his transcendent live show, Live In Brooklyn features renditions of fan-favorites and global hits including the Gold-certified “One Day” – whose original version has been streamed over 150 million times on Spotify alone – and the genre-bending, Billboard Hot 100-charting and alt-radio topping breakthrough single “King Without A Crown.”We want to hear from you! Please email Hello@BringinitBackwards.comwww.BringinitBackwards.com#podcast #interview #bringinbackpod #Matisyahu #OneDay #KingWithoutACrown #NewMusic #ZoomListen & Subscribe to BiBhttps://www.bringinitbackwards.com/followFollow our podcast on Instagram and Twitter! https://www.facebook.com/groups/bringinbackpod

It is Christmas Eve, and I thought “what better way to celebrate the holidays than to have a special feature!!” So, with the quick response from Lily over DMs, we were able to schedule a meeting call to talk all things platforming, podcasting, and marketing! Yes, we will also mention our personal lives - which is why you all listen, right? Kidding! Without further rambling, I truly hope you have a very Merry Christmas and a Happy New Years!! Xx the WakeUpConservative

Principle 7, Philippians 2:9-18Exemplifying the IncarnationTo demonstrate to the world who Jesus Christ is, we are to work out our salvation.Support the show

The Torus, First identified by the ancient greeks, the torus is a donut-shaped flow of energy. Exemplifying the as above so below concept, the toridal is found at the micro and macro level. From the Milky Way Galaxy down to the atom with its invisible force field. Nature displays the torus in an abundance. The Law of Reciprocity demonstrates that an outward flow of energy will then return to the source of activation, as with the torus. The ultimate feedback loop. Today we will present a background of the toridal field, how to use the energy in your own body, how to create a torus field energy device, and the future implication of this abundant energy field. --- Support this podcast: https://podcasters.spotify.com/pod/show/thoughtrebellion/support

Philippians Principle 7 – Exemplifying the IncarnationTo demonstrate to the world who Jesus Christ is we are to work out our salvation.Support the show

How are you integrating core values into your nonprofit's everyday work? Are you utilizing these values as a decision tool and a means for navigating your organization through changes? How do all of your employees, from those on the front lines to the leadership team embody core values every day?  In this episode, special guest Chad Zibelman talks about how he and his organization integrate core values into their everyday work. He discusses how to use these values to help your organization grow by leveraging your professional network, building a flexible organization, and strategically looking at “failure.” Chad also gives us practical tips for building relationships with donors all while advocating for your organization's mission, and turning to these values to know when to say no. On top of all of that, Chad also tells us how he lands the ever-sought-after corporate partnerships.    About Chad: Chad Zibelman is the CEO of The Sonder Project, an international 501(c)(3) non-profit organization whose mission is to empower impoverished communities through high-impact, sustainable development. Chad grew up in the Philadelphia area and graduated from Temple University with a degree in Education. He then joined the Peace Corps and taught in a rural school in the African country of Namibia. Upon completion of his service, Chad returned to the US and began an 8-year career with the non-profit organization buildOn.  buildOn constructs schools in developing countries and Chad worked his way up to become Trek Director, responsible for a program that brought over 1,000 volunteers/year abroad to immerse in communities and help build schools. The founders of The Sonder Project came to know Chad when they participated in a buildOn Trek to Burkina Faso in 2015, and three years later, they asked him to lead the organization. Chad resides with his wife, two daughters, and their pet rabbit in Sonoma County, CA. Read the podcast transcript here.   Episode Summary: In today's episode, you'll learn strategies for meaningfully integrating your organization's core values into your everyday work including: Leveraging your professional network to help your organization grow (9:05) Strategies to implement for a more flexible organization (10:45) A different way to look at “failure” (14:10) Building relationships with donors and supporters (16:30) Advocating for your organization's vision (20:15) Exemplifying your core values in your everyday work (22:30) Utilizing your core values as a decision-making tool (24:20) Landing corporate partnerships (27:25) Incorporating core values into your interview process (36:00)   Teasers: “We really try to live by our values. One of our values is to listen to others, and that includes our beneficiaries, includes partners on the ground, includes our donors, but we take that seriously.” “I think it's important for individuals working, whether it's a small organization or a big organization, to not be afraid of the vision that you set and to make sure you are a constant advocate for that vision.” “It was a really collaborative experience with all of our board members and our staff to understand what drives us.” “Creating an environment where people are not afraid to speak their minds and share in a safe space only allows the whole organization to be more prosperous.”   Huge thank you to our sponsor, Grants Works! With billions of dollars in federal grant funding available, now is the time to learn about how to apply for and manage federal grants from Patrice Davis, an expert who simplifies federal grants. Her Federal Grants Simplified Bootcamp is a six-week hybrid training that gives you the freedom to access on-demand training on your schedule and to attend live weekly Q&A sessions with Patrice. Plus, GrantsWorks is an ACFRE approved continuing education provider. Use code DEGREES for 10% off your registration.   Resources: Connect with Chad on LinkedIn: www.linkedin.com/in/czibelman/ The Sonder Project: thesonderproject.org  Grantsworks: www.grantsworksacademy.com/federal-grants-simplified  Keep up to date with the podcast: @100degreesconsulting Follow Stephanie on Instagram: @stephanie.skry/  Connect with Stephanie on LinkedIn: https://www.linkedin.com/in/stephanieskryzowski/  Visit the podcast page: 100degreesconsulting.com/integrating-core-values   Want more of the podcast? New episodes are released weekly! Find them all plus show notes and exclusive bonus content at 100degreesconsulting.com/podcast. Leave us a review! Click here, scroll to the bottom, tap to rate with five stars, and select “Write a Review.” Let me know what you loved most about this episode! Subscribe to the show so you don't miss a thing!

Holy Shenanigans Practioner Rev. Tara L. Eastman caught up with her colleague Rev. Dr. Deborah Roof at this summer's Wild Goose Festival, to hear all about Words, Wonder and the Divine in You - a new book release. Deborah Roof, a queer Christian pastor, is an enthusiastic life-long learner and a passionate teacher. She is an ordained minister in the United Church of Christ with a Master of Divinity degree from Colgate Rochester Crozer Divinity School and a Doctor of Ministry in Preaching from the Chicago Theological Seminary.In her new book, “Words, Wonder, and the Divine in You”, Roof shares her experience, strength and hope and invites the reader to take their own spiritual journey.  Exemplifying her authentic gift of hospitality Roof shares the truth she has come to know: divinity dwells within each one of us. She finds God in the wonder of the created world and in the scriptures she has come to love. Deborah and her wife, Liz, have four adult daughters, their daughters' four spouses, and four grandchildrenSupport the showWhen in Western New York, please join Pastor Tara in worship at First Presbyterian Church of Jamestown NY on Sundays at 10:30 am.

Radhika Vekaria: Music as a Mirror to the SoulAired Monday, September 25, 2023 at 11:00 AM PST / 2:00 PM EST / 7:00 PM GMT / 8:00 PM CETEmbark on a transformative journey from the head to the heart as we welcome the extraordinary Radhika Vekaria to the Voice Rising Show. Exemplifying the essence of the Vedic goddess Radha, Radhika's voice is a potent blend of love, devotion, and vibrational healing, a fusion shaped by her Indian, East African, and British heritage.Our conversation will dive into Radhika's new soul-stirring single, “Kali,” an anthem celebrating the power of the feminine divine. As a teacher of Sound Coaching, Radhika will offer insights into harnessing the transformative and healing vibrations of your own voice to shape your reality—a concept as ancient as it is groundbreaking, a notion echoed by quantum physicists and ancient seers alike.Despite facing a lifelong speech impediment, Radhika courageously turned to music as her voice, stating, “While words struggled, music effortlessly carried them.” With a career that has seen her grace stages from Europe to the United States and collaborations with Grammy-nominated producers like George Landress, she continues to inspire audiences globally. Recently, Radhika has been a commanding presence in the digital realm, amassing over 100,000 listeners on Clubhouse and sharing the stage with legends like Rihanna and Sir Paul McCartney.From her early exposure to classical Indian music, led by her father's passion, to her transformative album ‘SAPTA: The Seven Ways,' Radhika is more than a musician; she's a healer, an advocate, and a spiritual guide. “I don't make music for you to see me. I make music for you to see yourself,” she asserts. Don't miss this opportunity to explore the vast universe of sound and its life-changing possibilities. Tune in as we unravel the layers of Radhika Vekaria's multifaceted artistry and commitment to global causes like Yoga Gives Back and Art of Living Global events.Join us for an experience that promises not only to entertain but also to enlighten and empower.Visit Radhika Vekaria at https://www.radhikavekaria.com#RadhikaVekaria #Music #VoiceRising #KaraJohnstadTo get in touch with Kara, go to http://www.karajohnstad.com/Visit the Voice Rising show page https://omtimes.com/iom/shows/voice-rising/Subscribe to our Newsletter https://omtimes.com/subscribe-omtimes-magazine/Connect with OMTimes on Facebook https://www.facebook.com/Omtimes.Magazine/ and OMTimes Radio https://www.facebook.com/ConsciousRadiowebtv.OMTimes/Twitter: https://twitter.com/OmTimes/Instagram: https://www.instagram.com/omtimes/Linkedin: https://www.linkedin.com/company/2798417/Pinterest: https://www.pinterest.com/omtimes/

BlueCollar.CEO –Chad Peterman is the CEO and President of Peterman Brothers Heating, Cooling & Plumbing, a family-owned and operated company that provides the best HVAC, plumbing, and electrical careers in Indiana. Established by Chad's father in 1986, the company employs more than 250 people and owns more than 100 trucks servicing satisfied customers. They maintain an A+ rating with the Better Business Bureau and are recipients of the Angie's List Super Service Award.Chad firmly believes growing your company begins with empowering your employees. Exemplifying his mission, Chad founded Peterman Top Tech Academy, a trade school specializing in restoring honor and tradition to the trades, which prepares its graduates for a career in the family business. In this episode, Ryan and Chad come together again to discuss the value of empowering your employees, leadership philosophies, and what Chad found to be the most beneficial decision he has ever made. 

Have you ever found yourself struggling to maintain your fitness and nutrition routines while traveling for competitions? Join us as we share our personal experiences and tips on how to take care of yourself during these trips, such as focusing on protein intake and maintaining your meal routines when possible. In this episode, the Director of Coaching at Hard Work Pays Off (HWPO), Jake Marconi and I explore how to maintain your fitness while traveling, the benefits of bodybuilding and powerlifting for Crossfitters and strength athletes alike, the critical role culture plays in coaching, and how it can be cultivated. Listen in as we reveal our experiences in building lasting culture and the importance of investing time in employees to guide them in the right direction. Discover our insights on how exemplifying the desired culture, being collaborative, and allowing for differing opinions can create a strong team environment that extends far beyond fitness. Lastly, join us as we take a deep dive into the importance of discovering your passion and influence and how it's essential to share your experiences and knowledge with others. We reflect on the concepts of legacy, mortality, and how gaining wisdom through perspective can lead to a more fulfilling life. Don't miss our conversation on the alignment of personal goals and the pursuit of high achievement, as well as the importance of understanding the utility of our beliefs. “Those beliefs could change the world…and they could also ruin your life, if you let them.” Click here to watch this week's episode on Youtube! --------- EPISODE CHAPTERS --------- (0:00:01) - Traveling Fitness Strategies (0:12:08) - The Benefits of Bodybuilding Training (0:22:30) - The Importance of Culture in Coaching (0:29:42) - Building Lasting Culture Slowly (0:35:25) - Discovering Your Passion and Influence (0:47:16) - Perspective on Legacy and Mortality (1:01:56) - Alignment and Fulfillment in High Achievement (1:12:30) - Defining Terms and Utility of Beliefs Links: Connect with Micah Connect With Jake Marconi Resources: Start your journey as an elite-level CrossFit athlete today. Our 1-to-1 coaching staff would love to hop on a free consultation with you to find out how we can help.  Click here to get started. Reviews:  Enjoy the show? Take a second to leave us a review! Your feedback will help us grow and continue to produce more sweet, sweet content in the future. Give us a follow on social media below for daily workouts & inspiration: Instagram Facebook Website Youtube

“If you only had two hours a day to work, what is the highest and best use of your value, relevance, and impact in that two hours?”In this episode, Rebecca shares a powerful coaching session she had with a client who experienced profound adversity. The episode explores the importance of intentional presence in leadership, the long-term perspective in decision-making, and the value of self-awareness and regulating one's nervous system. Listen in to discover practical insights for achieving greater clarity, impact, and personal growth in your life and business.In this episode, you'll learn:Explore how being fully present in your leadership role can positively impact your decision-making, communication, and overall effectivenessGain a deeper understanding of the value of taking a long-term view when making decisions in both life and businessDiscover self-awareness's significance and understanding of your nervous system responses in navigating challenges and adversityThings to listen for:[09:11] Unveiling true self-awareness[11:03] The journey towards self-awareness and human connection[16:52] Mastering self-regulation to unleash the power of your nervous systemResources:Learn more about Rebecca and her workGet your copy of Write Your Own StoryListen to Rebecca's Audiobook Write Your Own StoryTake the Badass QuizConnect with Rebecca:https://www.linkedin.com/in/rebeccafleetwoodhession/https://www.instagram.com/rebeccafleetwoodhession/https://www.facebook.com/fleetwoodhession/https://www.tiktok.com/@rebeccafleetwoodhession

Understanding the Ten Commandments; What you think Christianity is; Hypocrisy of modern Christianity; Passover; Eating a whole lamb; Sharing; Pure religion; Trees of Knowledge and of Life; In the beginning; Adamah; Divine spark; Artificial Intelligence; Are you self-aware?; Words having changed meanings; What do you know of God?; The Flood; Right to choose; vs "Pro Choice"; Forgiveness; Did God kill Pharaoh's men?; Do you listen to God?; Giving your neighbor freedom; Revealing truth; Men and Women; Families; Sacrifice for righteousness; Ex 20:1; I am; Elohim, the office; Brought out of = yod-tzdek-aleph; House of Jacob vs Israel; Nearing the Tree of Life; Seeing Moses' truth; Covenanting with other gods; Graven images; Idolatry; "Hate" lamad+shin-nun-aleph+yod; genetic memory; Serving idols; Saving your family; Joseph's weeping; Learning lessons; Having Holy Spirit within you; Taking God's name; It's not good that you be alone; "Within thy gates"; Sabbath; Debt; Honoring parents; Killing; Adultery/fornication; Stealing; Horse thieving; Gossip; Coveting; Drafting; Slavery in Egypt?; Corvee bondage; Institutions of forcing neighbor; Euthanasia; Degeneration of society; Loving God and neighbor; Modern church acceptance of covetousness; Becoming merchandise; Following God's guideposts; Seeking the fruits of God's kingdom; Fear from the light; Defeating evil; v19 - statement of pride; Fear not!; Hating wise counsel; Do you love the light?; Gods of silver and gold - reserve funds; Talking with animals; Exemplifying creation; Realizing God's patterns; Altars; Caring about neighbor as self; "Hewn stones"; Burnt offerings; Regulating ministers; Hierarchy in the kingdom; No exercising authority; Organize yourselves per God's spirit.

In episode 5 of The Salice Rose Show, Salice and her guest discuss the pain and life-altering effects that come with mental, emotional, and physical abuse in relationships. Exemplifying complete honesty throughout this triggering episode, Salice and her guest open up about their own personal experiences as victims of abuse in their very own romantic relationships as well as the obstacles they faced when attempting to leave those relationships. They vulnerably share their own coping mechanisms, resources for help, their own individual paths to healing, and the reasons behind why transitioning into a healthy relationship was so difficult. Tune in for an insightful and eye-opening episode that will simultaneously tug on some heart strings while encouraging the discovery of each person's own path to self-healing.The Salice Rose Show is intended for mature audiences only and is not suitable for children. This content may contain adult themes, explicit language, and sexual subject matter. The views, thoughts, and opinions expressed are the speaker's own.

Institution for Global Engagement's Nick Pitts talks about sharing with our culture the good design that God made for the human condition and the religious fervor that follows pandemics. Philos Project's Luke Moon outlines the factors involved with giving aid to struggling countries and how our God is still very much at work in the midst of serious conflict. Click here for today's show notes Faith Radio podcasts are made possible by your support. Give now: Click here

In this episode, Wellness Within Founder Patti Brown, MS LMFT is joined by our returning honored guest, Cynthia Li, MD. In this in-depth conversation, Dr. Li shares about her transformational experiences of grief, while providing insightful and uplifting wisdom for those who are ready to hear it. This episode invites listeners to see themselves in how they relate to the holding and release of their own grief.  Exemplifying how healing and grieving is not always linear, and how "you can't heal what you don't feel or what you are not connected to".  Are you ready?And in cased you missed their last podcast conversation together, be sure to check out the episode, Qigong Demystified with Dr. Cynthia Li where she shares how Zhineng (Wisdom Healing) Qigong contributed to her radical remission of  an autoimmune thyroid condition, and her observation of how science is evolving to measure and support the benefits of this ancient practice. Dr. Cynthia Li is a doctor and author whose personal healing journey through a disabling autoimmune condition took her from public health in underserved populations, to integrative and functional medicine.Her personal health challenges began in 2005, and they expanded her beyond her conventional training. She has studied and practiced with functional medicine experts, environmental health scientists, acupuncturists, qigong masters, and alternative healers, weaving together cutting-edge science and ancient healing arts. Currently, she has a private practice in Berkeley, CA, and serves as faculty for the Healer's Art program at the University of California San Francisco Medical School.After becoming an anchor for Awakin Calls, a podcast of the global, all-volunteer-run ServiceSpace community of 2M+, she modeled her clinical services on the gift economy, where patients contribute into a community fund according to their abilities, giving and receiving from each other based on trust.She is author of the book, Brave New Medicine: A Doctor's Unconventional Path to Healing Her Autoimmune Illness.This podcast is sponsored in part by UC Davis Health, Elizabeth A. Harmon D.D.S., and Columbia Bank. It is offered freely to ensure everyone has access to these practices and conversations offered by Wellness Within Cancer Support Services. If you feel inspired to donate to support Wellness Within offerings, please visit www.wellnesswithin.org/giveBEACON is a self-paced online system that provides cancer patients, caregivers, and survivors a place to learn and practice wellness. It is designed to support the individual based on where they are in their cancer experience. Enroll at https://beacon.wellnesswithin.org/Support the show

Principle 7, Philippians 2:9-18Exemplifying the IncarnationTo demonstrate to the world who Jesus Christ is, we are to work out our salvation.Support the show

(00:00-10:48): Abortion is turning out to be a major midterm issue, and came up again recently in an interview with Stacy Abrams. (10:48-20:25): Brian and Aubrey talk about how conspiracy theories undercut Christians' testimony. (20:25-29:57): Protesters threw tomato soup on Van Gogh's sunflower painting. One pastor related it to salvation. (29:57-40:20): On ESPN, football player Jason Taylor mentored a young boy in a way that exemplifies God's love. (40:20-50:22): What's your take on the He Gets Us campaign? Brian and Aubrey share their thoughts. (50:22-59:28): Pastor David Mathis, a pastor and editor of desiringGod.org, joins Brian and Aubrey to talk about his new book: Workers for Your Joy: The Call of Christ on Christian Leaders.See omnystudio.com/listener for privacy information.

Bernadette Butler of Storytap sits down with Fast Frontiers host Tim Schigel to discuss the power of storytelling and connection. Bernadette is the CEO and Co-Founder of Storytap, and in this conversation discusses her path to creating the company, it's goals working with clients to help them gather stories from customers, and what her experience of bootstrapping the company has been like.Key takeaways: [00:56 - 05:49] Benadette's background[05:50 - 07:09] The origin of StoryTap[07:11 - 09:04] Where Bernadette met her co-founder Sean Braacx[09:08 - 11:56] What StoryTap is, and the trends it is capturing[11:56 - 13:51] Text, video, and influencers impact on brands[13:53 - 15:48] Ownership of the brand and assets, repurposing content to amplify message[15:52 - 18:17] A renewed emphasis on text, and navigating fake BS[18:19 - 19:35] Exemplifying work through your own content and clients[19:36 - 20:37] Discussing working with KY and Durex, sex education[20:40 - 21:30] Stories and connection[21:32 - 22:21] Text reviews and getting what you get[22:24 - 23:09] Some of Bernadette's customers[23:12 - 23:53] An incredible melting pot society[24:02 - 25:00] What it is like running a startup in Vancouver[25:01 - 26:28] What is next for StoryTap[26:44 - 27:26] Next week's episode with Joseph Hanna

JB Owen is a fearless female leader and a believer in the power of empowerment. JB's true focus is on helping others, which is why she started Ignite Publishing, the leader in empowerment publishing, in 2018. She is a world-class speaker, 18-time bestselling author, and powerful business owner who is committed to raising the vibration of the planet and igniting a billion lives through Ignite. She is motivated by the opportunity to assist individuals in breaking through their limiting beliefs to experience their own ‘ignite moment' which changes their perspective and positively alters the course of their life.She has published over 700 authors, turning them into international best-sellers in over 13 countries, with Ignite Publishing's books reaching #1 in 197 categories. Her gift is to Ignite people to share their stories and build their brands. She also owns Ignite Moments Media, JBO Global, and Lotus Liners. She combines purpose, passion, and possibilities in everything she does. Exemplifying a new paradigm of what's possible, JB motivates and inspires her clients to impact others and IGNITE humanity. Time Stamps: 2:20 - Spending $27,000 for a garage full of books 4:20 - Having it all but feeling like you have nothing 5:40 - Who she wrote her first book for 7:15 - Building a business to support others and not yourself 8:50 - Currency of success between females and males 11:50 - Staying authentic to yourself 13:20 - How JB is igniting humanity 16:45 - Connecting through the human experience 18:00 - Commercial 19:10 - JB's work with over 700 authors 20:30 - The year of the Legacy 22:00 - Ignite Possibilities School of Hope 23:32 - Ways to connect with JB 24:40 - Free affirmations from JB 25:10 - Free virtual mentorship program

Dave Snehal gives advice about achieving success and share his experiences with deals.Join our multifamily investing community for FREE for in-depth courses and live networking with like-minded apartment investors at the Tribe of TitansLink to subscribe to YouTube channel: https://tinyurl.com/SubYouTubeDiaryPodcastApple Podcasts: https://tinyurl.com/AppleDiaryPodcast Spotify: https://tinyurl.com/SpotDiaryPodcast Google Podcasts: https://tinyurl.com/GoogleDiaryPodcast Follow us on:Facebook: https://www.facebook.com/DiaryAptInv/ Twitter: https://twitter.com/Diary_Apt_Inv Instagram: https://www.instagram.com/diary_of_an_apartment_investor This episode originally aired on September 2, 2022----Your host, Brian Briscoe, has been a general partner in 655 units worth $50 million and has been lead sponsor, asset manager, capital raiser, and key principal on these properties. He has developed a multifamily education community called the Tribe of Titans that helps aspiring investors learn the game, network with other like-minded professionals, and get their apartment investing business to the next level. He is founder of Streamline Capital Group, which will continue to acquire multifamily assets well into the future. He retired as a Lieutenant Colonel in the United States Marine Corps in 2021.Connect with him on LinkedIn----Dave SnehalAs a commercial real estate agent/investor, Dave Snehal currently serves clients located in Chicago and the surrounding western suburbs. Always holding client satisfaction as his highest priority, Dave works hard to make the acquisition or disposition experience as efficient, productive, and enjoyable as possible. Clients working with him never fail to appreciate his compassion, professional integrity and commitment to helping them achieve their goals.Dave has extensive knowledge and experience that allows him to handle wide range of clients and situations. While clients are seasoned investors or new entrepreneurs, Dave is certain to provide them with a high level of guidance. Being native to the Chicago area, Dave is incredibly well-versed in the local market and always manages to find those hidden gems for his clients.He values his clients and strives to build strong, lasting relationships that go far beyond business. He understands how much clients and their families put on the line when they invest in real estate. That's why works closely with them every step of the way, making the otherwise overwhelming process, stress-free. Exemplifying passion for real estate and finding the right investments for his clients is of the greatest importance.When Dave isn't hard at work, he enjoys spending time with his wife Shelly and daughter Trinity. He has a passion for staying active in biking, hiking, running, and playing softball. He aspires to make an impact by donating time and resources to causes such as Habitat for humanity, DuPage Pads, and Packages4Patriots. Learn more about him at https://www.linkedin.com/in/davesnehal/