Podcasts about Williams College

Our guest for today's podcast is Richard Chau, Chief Investment Officer of the Tulane University Endowment. Richard joined Tulane in 2013 and was promoted to CIO in 2021. Prior to Tulane, Richard helped manage a multi-billion dollar global private equity portfolio in Bessemer Trust's Private Equity Funds Group. Before Bessemer, Richard worked in the investment office at The Andrew W. Mellon Foundation. His previous experience also includes investment banking at Houlihan Lokey and investment consulting at Cambridge Associates.   Richard has a BA in Economics and Chinese from Williams College and an MBA from Columbia Business School.   Without further ado, here is our conversation with Richard Chau.

Justin Bradley joined the Loyola University Chicago men's basketball staff in August 2023 as an assistant coach. Bradley most recently served as an assistant coach at Seattle U during the 2022-23 season, helping the Redhawks to a 20-12 record last year and a fourth-place finish in the Western Athletic Conference (WAC). Additionally, Bradley helped coach Cameron Tyson and Riley Grigsby to All-WAC honors this past season. Bradley has proven to be one of the nation's top young basketball coaches, being named to Silver Waves Media's 2021-22 and 2022-23 Most Impactful Mid Major DI Assistant Coaches list. He also earned recognition on the National Association of Basketball Coaches (NABC) prestigious 30-under-30 Team in 2018.Bradley went to the Pacific Northwest after spending six years in the Northeast. He was an assistant coach on staff at Dartmouth College in 2015-16, then spent two successful seasons (2016-18) at Williams College in Williamstown, Mass., helping the Ephs advance to the NCAA Division III Final Four in 2017 and finish both campaigns ranked fifth in the country.He was involved in all aspects of the recruiting process, assisting in game preparation and strategy while overseeing the player development for perimeter players. Three players earned All-NESCAC honors during his time at Williams, including 2018 Player of the Year and second-team All-American James Heskett.Bradley returned to Dartmouth as an assistant coach beginning in 2018-19, before being elevated to associate head coach prior to the start of the 2020-2021 season while recruiting and coaching current Rambler Dame Adelekun. Regarded as a top-notch teacher and a global recruiter, Bradley helped mentor several all-conference players including former Rambler Chris Knight (second team twice), Brendan Barry (second team) and Evan Boudreaux (Rookie of the Year/second team).To View This Episode- https://youtu.be/tMY7_nvwbps#whoknewinthemoment #philfriedrich #loyolachicago #loyola #podcast #ncaabasketball

In this episode of the Gotta Be Saints Podcast, I'm joined by Professor James Nolan, sociologist at Williams College and author of Atomic Doctors, for a powerful conversation on memory, martyrdom, and healing—centered on the Catholic history of Nagasaki and his work on the Nagasaki Bell Project.James shares the remarkable story of his grandfather, Dr. James Nolan, who served as a physician on the Manhattan Project and later traveled to Hiroshima and Nagasaki in the immediate aftermath of the atomic bombings. What began as a family legacy of moral complexity became a personal mission for healing and reconciliation through the gift of a new bell—donated by American Catholics—to replace the one destroyed at Urakami Cathedral.Together, we explore the deep Catholic roots of Nagasaki, the heroic endurance of the hidden Christians, and how their suffering bore fruit through forgiveness, faith, and restoration.Topics Covered:The forgotten Catholic history of Nagasaki and its "hidden Christians"Why Urakami Cathedral was the ground zero for Japan's Catholic faithThe life and witness of Takashi Nagai and post-bomb theology of redemptive sufferingTensions faced by Catholic doctors during the Manhattan ProjectThe story behind the Nagasaki Bell Project and how Catholics today can helpWhy the legacy of martyrdom still speaks to us in a divided and war-torn worldHow the new bell—named The Kateri Bell of Hope—will ring out once again on August 9, 2025

Unlocking the Future of Smart Home Technology: Insights from Hagan Kappler, CEO of DaisyIn this episode of The Thoughtful Entrepreneur, host Josh Elledge welcomes Hagan Kappler, the founder and CEO of Daisy, a company on a mission to redefine smart home and small business technology services. Hagan shares how Daisy is creating a national brand in an otherwise fragmented industry—one that offers not just installation, but also consistent, long-term support.Whether you're a consumer seeking a better smart home experience or an entrepreneur interested in franchise ownership, this conversation uncovers the technology trends, business models, and growth opportunities shaping the future of connected living.Redefining Smart Home Services Through Standardization and SupportAs the smart home market continues to expand—now exceeding $30 billion in the U.S. alone—it still faces serious fragmentation. Many technology contractors are small, local operators with deep product knowledge but limited business infrastructure. Hagan Kappler launched Daisy to solve this problem by offering a platform where talented installers can operate under one cohesive, national brand with the support they need to scale.Daisy provides solutions ranging from home audio and visual systems to smart lighting, security, motorized shades, and fully integrated control panels. But what truly sets Daisy apart is their ongoing commitment to service. Unlike typical one-off installations, Daisy ensures homeowners, builders, and property managers receive continual updates, maintenance, and training—maximizing the longevity and effectiveness of their smart systems.For small business owners, Daisy's franchise model opens doors. Entrepreneurs can either start a new operation, convert an existing business, or acquire a company, all while receiving centralized support in operations, marketing, customer service, and technology. It's a win-win: customers enjoy trusted expertise, and franchisees get to grow under a brand backed by national reach.About Hagan KapplerHagan Kappler is the founder and CEO of Daisy, the first national brand in smart space installation and services. Previously, she served as CEO of Threshold Brands, leading nine service businesses across 550+ locations. Hagan has held leadership roles with ServiceMaster Clean, Merry Maids, and Ingersoll Rand/Trane, and began her career at McKinsey & Company and Goldman Sachs. She also helped launch Starbucks Blonde Roast. Hagan holds a bachelor's in history from Williams College and an MBA from the University of Virginia's Darden School. She lives in Newport Beach, CA with her four children.About DaisyDaisy is redefining smart home and business technology with a comprehensive, customer-first approach. By combining expert installation with long-term service, Daisy offers audio-visual, lighting, security, and automation solutions tailored to every client. Franchise partners benefit from marketing, HR, customer support, and operational tools that make running a tech business easier and more profitable. Learn more at joindaisy.com.Links Mentioned in this EpisodeVisit Daisy's WebsiteConnect with Hagan Kappler on LinkedInKey Episode HighlightsHow Daisy fills a major gap in the smart home market by providing both installation and ongoing serviceThe opportunity for small business owners to scale through Daisy's national franchise modelWhy the...

In this episode, Dr. Jason Storm returns to explore the relationship between science, religion, and meaning in the modern world. Starting with Storm's work on The Myth of Disenchantment, they discuss how the conventional narrative of modernity leading to widespread secularization and loss of magical/spiritual thinking is largely inaccurate. Storm explains how this narrative emerged in the 19th century while spiritualism and occult movements were actually flourishing. They examine the fragmentation of belief systems, the historical transformation of faith and epistemology, and how various "meaning crises" arise in contemporary society. The conversation touches on capitalism's relationship with environmental degradation, our connection to nature as a source of meaning, and the limitations of postmodernism. Storm advocates for a metamodern approach that encourages epistemic humility, community engagement, and brave spaces for meaningful dialogue to address complex social problems. You can read more about it in Metamodernism: The Future of Theory and check out his previous visit to the podcast, where we discuss it here. You can WATCH the conversation on YouTube Jason Ananda Josephson Storm is chair and professor of religion and chair of science and technology studies at Williams College. He is a scholar and author whose work focuses on the intersection of religion, science, and meaning in modern society. He has written several influential books including The Myth of Disenchantment, which challenges conventional narratives about secularization and modernity, and Metamodernism and the Future of Theory, which proposes new frameworks for moving beyond postmodern skepticism. Storm teaches courses on philosophy and meaning, including a popular class on "The Meaning of Life," where he introduces students to diverse philosophical and religious traditions. His research examines how individuals navigate belief systems in a fragmented cultural landscape, the relationship between institutional authority and personal meaning-making, and constructive approaches to addressing contemporary social crises. Storm advocates for epistemic humility, community engagement, and creating "brave spaces" for meaningful dialogue across differences. THEOLOGY BEER CAMP | Oct 16-18, 2025 | St. Paul, MN 3 Days of Craft Nerdiness with 50+ Theologians & God-Pods and 600 new friends. ONLINE CLASS ANNOUNCEMENT: The Many Faces of Christ Today The question Jesus asked his disciples still resonates today: "Who do you say that I am?" Join our transformative 5-week online learning community as we explore a rich tapestry of contemporary Christologies. Experience how diverse theological voices create a compelling vision of Jesus Christ for today's world. Expand your spiritual horizons. Challenge your assumptions. Enrich your faith. As always, the class is donation-based (including 0), so head over to ManyFacesOfChrist.com for more details and to sign up! _____________________ Hang with 40+ Scholars & Podcasts and 600 people at Theology Beer Camp 2025 (Oct. 16-18) in St. Paul, MN. This podcast is a Homebrewed Christianity production. Follow the Homebrewed Christianity, Theology Nerd Throwdown, & The Rise of Bonhoeffer podcasts for more theological goodness for your earbuds. Join over 80,000 other people by joining our Substack - Process This! Get instant access to over 45 classes at www.TheologyClass.com Follow the podcast, drop a review, send feedback/questions or become a member of the HBC Community. Learn more about your ad choices. Visit megaphone.fm/adchoices

ORIGINALLY RELEASED Jan 8, 2024 Dr. Joy James joins Breht and PM for the third installment of Rev Left's ongoing Du Bois series, but this conversation goes well beyond the life and work of Du Bois to cover James' newest book, her long history of organizing, the history of black liberation struggles in the US, and much more. Together, they discuss George Jackson, James' concept of the Captive Maternal, Erica Garner, "New Bones Abolition", Marxism, black history, Ida B. Wells, and much more. Overall its a wide-ranging conversation with an incredibly wise and experienced revolutionary intellectual.  Dr. James is Ebenezer Fitch Professor of Humanities at Williams College. Her book is New Bones Abolition: Captive Maternal Agency and the (After)life of Erica Garner.  Proceeds from New Bones Abolition: Captive Maternal Agency and the (After)Life of Erica Garner go to Prison Radio. Follow PM on IG ---------------------------------------------------- Support Rev Left and get access to bonus episodes: www.patreon.com/revleftradio Make a one-time donation to Rev Left at BuyMeACoffee.com/revleftradio Follow, Subscribe, & Learn more about Rev Left Radio HERE Outro Beat Prod. by flip da hood

Today on the Salience podcast we're diving deep into the complex world of health systems—and the concept of synergy. As demands on health systems grow, leaders are often caught in the tension between delivering day-to-day services and driving systemic change. So how do they balance it all?Joining us to unpack these challenges is Helena Harnik, co-founder and Program Executive Director at The Synergist. With a background spanning global corporations and a passion for collaborative innovation, Helena brings a unique lens to the conversation. She holds an international MBA from EM, Lyon in France, and a BA in English Literature from Williams College in the U.S.Whether you're a health professional, policy thinker, or just curious about how complex systems can evolve, this episode has something for you. For more information about The Salience Podcast and Frontline Mind please visit our website at https://www.frontlinemind.com/the-salience-podcast/ You can also sign up for our newsletter here https://frontlinemind.us17.list-manage.com/subscribe?u=ff181d12c77d7cea5f19a2c48&id=fd7357f614

Autism diagnoses are rising, but so is a quiet revolution in how we understand and address them. In this powerful conversation, Beth Lambert, Founder and Executive Director of Documenting Hope, shares her journey from conventional healthcare insider to trailblazing leader in root-cause healing for children with chronic conditions. Beth Lambert is the Founder and Executive Director of Documenting Hope, a 501(c)(3) nonprofit organization dedicated to reversing the epidemic of chronic health and developmental conditions in children. A former healthcare consultant and teacher, she has extensively researched the environmental and lifestyle factors contributing to modern pediatric health crises. Beth is the author of A Compromised Generation: The Epidemic of Chronic Illness in America's Children and co-author of Brain Under Attack: A Resource for Parents and Caregivers of Children with PANS, PANDAS, and Autoimmune Encephalitis. She has also co-authored peer-reviewed research on autism symptom reversal. Beth holds degrees from Williams College and Fairfield University, and has studied at Oxford University. Beth and Jamie dive deep into the environmental, medical, and lifestyle triggers contributing to the explosion of pediatric diagnoses—and what families can do to take back control. From gut health to toxic exposures, vaccine timing to generational patterns, this episode dismantles the myth that chronic illness is permanent and introduces a new, evidence-backed paradigm: personalized, bio-individual healing is possible—and it's happening. Documenting Hope is doing exactly what their name says—documenting these incredible, triumphant stories to provide proof and HOPE. Whether you're a parent, practitioner, or advocate for health freedom, this episode will challenge what you've been told and offer real hope backed by science. Resources from this Episode: Documenting Hope Learn more about Beth's organization, read real recovery stories, or get involved: https://documentinghope.com Healing Together Membership Community A supportive space for parents navigating chronic conditions in children, with live calls and resources: https://documentinghope.com/healing-together The Flight Study (Documenting Hope's longitudinal intervention study): https://documentinghope.com/flight-study CHIRP Study (Child Health Inventory for Resilience and Prevention): https://documentinghope.com/chirp-study Recommended Book How to Raise a Healthy Child in Spite of Your Doctor by Dr. Robert Mendelsohn: https://www.amazon.com/dp/0345342763 Nutritional Therapy Foundation Course Perfect for parents looking to level up their family's wellness with nutrition basics: https://nutritionaltherapy.com/ntf Donate to Documenting Hope Support independent, agenda-free research: https://documentinghope.com/donate Follow Jamie on X (formerly Twitter) For news, podcast clips, and community conversation: https://twitter.com/jamielynnbelz

In this episode of Talk Nerdy, Cara is joined by historian, ecologist, and environmental studies professor at Williams College, Dr. Laura J. Martin. They discuss her book, “Wild by Design: The Rise of Ecological Restoration.” Follow Laura: @Laura_J_Martin

Karen Russell's “The Antidote” follows five characters whose fates become entangled after a storm ravages their fictional small town of Uz, Nebraska. Together, the group of outcasts join forces to reveal the town's secrets and show the importance of remembering and acknowledging injustices to create a better future.Russell has received MacArthur and Guggenheim Fellowships and was a finalist for the Pulitzer Prize for her debut novel “Swamplandia.” She has taught literature and creative writing at the Iowa Writers' Workshop, the University of California-Irvine, Williams College, Columbia University, and Bryn Mawr College, and was the Endowed Chair of Texas State's MFA program. She serves on the board of Street Books, a mobile-library for people living outdoors. Born and raised in Miami, Florida, she now lives in Portland, Oregon with her husband, son and daughter. “The Antidote” is Russell's second novel. She will be at The Bookworm at 6 p.m. on April 3 in conversation with Broc Anderson of the Nebraska State Historical Society.Russell and Michael Griffin discuss the role of intellect and imagination in writing, the natural world's influence on the artistic process and the symbiotic relationship between the author and reader.

Katy Hays is the New York Times bestselling author of The Cloisters. She is an art history adjunct professor and holds an MA in art history from Williams College and pursued her PhD at UC Berkeley. Having previously worked at major art institutions, including the Clark Art Institute and SFMOMA, she now lives with her husband and their dog in Olympic Valley, California.Killer Women is copyrighted by Authors on the Air Global Radio Network#podcast #author #interview #authors #KillerWomen #KillerWomenPodcast #authorsontheair #podcast #podcaster #killerwomen #killerwomenpodcast #authors #authorsofig #authorsofinstagram #authorinterview #writingcommunity #authorsontheair #suspensebooks #authorssupportingauthors #thrillerbooks #suspense #wip #writers #writersinspiration #books #bookrecommendations #bookaddict #bookaddicted #bookaddiction #bibliophile #read #amreading #lovetoread #daniellegirard #daniellegirardbooks #ballantine #katyhays #newyorktimesbestseller

Katy Hays is the New York Times bestselling author of The Cloisters. She is an art history adjunct professor and holds an MA in art history from Williams College and pursued her PhD at UC Berkeley. Having previously worked at major art institutions, including the Clark Art Institute and SFMOMA, she now lives with her husband and their dog in Olympic Valley, California. Killer Women is copyrighted by Authors on the Air Global Radio Network #podcast #author #interview #authors #KillerWomen #KillerWomenPodcast #authorsontheair #podcast #podcaster #killerwomen #killerwomenpodcast #authors #authorsofig #authorsofinstagram #authorinterview #writingcommunity #authorsontheair #suspensebooks #authorssupportingauthors #thrillerbooks #suspense #wip #writers #writersinspiration #books #bookrecommendations #bookaddict #bookaddicted #bookaddiction #bibliophile #read #amreading #lovetoread #daniellegirard #daniellegirardbooks #ballantine #katyhays #newyorktimesbestseller

Katy Hays is the New York Times bestselling author of The Cloisters. She is an art history adjunct professor and holds an MA in art history from Williams College and pursued her PhD at UC Berkeley. Having previously worked at major art institutions, including the Clark Art Institute and SFMOMA, she now lives with her husband and their dog in Olympic Valley, California. Killer Women is copyrighted by Authors on the Air Global Radio Network #podcast #author #interview #authors #KillerWomen #KillerWomenPodcast #authorsontheair #podcast #podcaster #killerwomen #killerwomenpodcast #authors #authorsofig #authorsofinstagram #authorinterview #writingcommunity #authorsontheair #suspensebooks #authorssupportingauthors #thrillerbooks #suspense #wip #writers #writersinspiration #books #bookrecommendations #bookaddict #bookaddicted #bookaddiction #bibliophile #read #amreading #lovetoread #daniellegirard #daniellegirardbooks #ballantine #katyhays #newyorktimesbestseller

Kelly Bonnell is Chief Operations Officer of Constellation Wealth Partners.   Kelly brings expertise in process and strategic planning from a career dedicated to managing the organizational operations of scaling companies.She was instrumental in the success of her family's business, BGR, Inc. where she led the company's strategic planning and growth efforts in her position as COO.  In this role, she focused on integrating the major functions of the business to execute annual strategic plans and achieve the company's financial goals.Kelly is a graduate of Leadership Cincinnati Class 47. She was also a member of C-Change, Class 8 and WE Lead, Class 11 – all three leadership development programs offered by the Cincinnati USA Regional Chamber. She was named one of Cincinnati's Forty Under 40 by the Business Courier and winner of the 2018 Larry Grypp Rising Leader Award. Kelly is a graduate of the University of Dayton and Xavier University's Williams College of Business.   She lives in Greater Cincinnati with her husband Todd and two children.    

We delve into the life of mystery man Frank, a multifaceted individual whose contributions to early American football remain surprisingly obscure despite their profound significance. As a championship-winning captain at Williams College, he not only led his team to a Tri Collegiate Football Association championship but also excelled as a track star, showcasing his athletic prowess across multiple disciplines. Following his graduation, he transitioned into coaching, leaving an indelible mark on several collegiate programs, including Colgate and Columbia, where he successfully revitalized the football program. His legacy extends beyond the collegiate level, as he played a pivotal role in the inaugural indoor professional football game at Madison Square Garden. This episode invites listeners to uncover the remarkable and largely forgotten narrative of Frank Buck O'Neill, a true architect of the gridiron's history.Join us at the Pigskin Dispatch website and the Sports Jersey Dispatch to see even more Positive football news! Sign up to get daily football history headlines in your email inbox @ Email-subscriberDon't forget to check out and subscribe to the Pigskin Dispatch YouTube channel for additional content and the regular Football History Minute Shorts.Miss our football by the day of the year podcasts, well don't, because they can still be found at the Pigskin Dispatch website.

Send us a textIn this illuminating episode of Roots to Renewal, host Martin Ping engages with Spencer Beebe, a pioneering conservation leader who founded influential organizations including Salmon Nation, Conservation International and EcoTrust.Spencer shares his remarkable journey and the development of his visionary concept "Salmon Nation," which reimagines conservation through the lens of bioregional identity and community empowerment. Throughout the conversation, Spencer illustrates how grassroots leadership is transforming environmental stewardship across the Pacific Northwest and beyond.The discussion explores Spencer's philosophy that true ecological health is inseparable from community wellbeing, emphasizing the importance of empowering local "raven" leaders who understand their regions intimately. His approach focuses on restoring our fundamental connection to place as a critical pathway forward in addressing environmental challenges.Listeners interested in learning more about Spencer Beebe's transformative work can visit ecotrust.org and salmonnation.net.About Spencer Beebe:Spencer B. Beebe, Ecotrust Founder and Board Chairman, earned his MFS (Forest Science) degree in 1974 from Yale University's School of Forestry and Environmental Studies and a B.A. in Economics from Williams College in 1968. He served with the Peace Corps in Honduras from 1968-71 and, after serving 14 years with The Nature Conservancy as Northwest representative, Western Regional Director, Vice President and President of the Nature Conservancy's International Program, he was the founding President of Conservation International in 1987. In February 1991, Spencer founded Ecotrust; with Shorebank Corporation of Chicago he helped found ShoreBank Pacific, the first environmental bank, now OnePacific Coast Bank. In addition to his work with Ecotrust, Spencer serves on the board of Walsh Construction Company and the Ecotrust Board of Directors. He is the author of Cache: Creating Natural Economies. Thanks for listening to Hawthorne Valley's Roots to Renewal podcast. We are an association comprised of a variety of interconnected initiatives that work collectively to meet our mission. You can learn more about our work by visiting our website at hawthornevalley.org. Hawthorne Valley is a registered 501c3 nonprofit organization, and we rely on the generosity of people like you to make our work a reality. Please consider making a donation to support us today. If you'd like to help us in other ways, please help us spread the word about this podcast by sharing it with your friends, and leaving us a rating and review.If you'd like to follow the goings-on at the farm and our initiatives, follow us on Instagram!

Funding for the NIH and US biomedical research is imperiled at a momentous time of progress. Exemplifying this is the work of Dr. Anna Greka, a leading physician-scientist at the Broad Institute who is devoted to unlocking the mysteries of rare diseases— that cumulatively affect 30 million Americans— and finding cures, science supported by the NIH.A clip from our conversationThe audio is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.Transcript with audio and external linksEric Topol (00:06):Well, hello. This is Eric Topol from Ground Truths, and I am really delighted to welcome today, Anna Greka. Anna is the president of the American Society for Clinical Investigation (ASCI) this year, a very prestigious organization, but she's also at Mass General Brigham, a nephrologist, a cell biologist, a physician-scientist, a Core Institute Member of the Broad Institute of MIT and Harvard, and serves as a member of the institute's Executive Leadership Team. So we got a lot to talk about of all these different things you do. You must be pretty darn unique, Anna, because I don't know any cell biologists, nephrologists, physician-scientist like you.Anna Greka (00:48):Oh, thank you. It's a great honor to be here and glad to chat with you, Eric.Eric Topol (00:54):Yeah. Well, I had the real pleasure to hear you speak at a November conference, the AI for Science Forum, which we'll link to your panel. Where I was in a different panel, but you spoke about your extraordinary work and it became clear that we need to get you on Ground Truths, so you can tell your story to everybody. So I thought rather than kind of going back from the past where you were in Greece and somehow migrated to Boston and all that. We're going to get to that, but you gave an amazing TED Talk and it really encapsulated one of the many phenomenal stories of your work as a molecular sleuth. So maybe if you could give us a synopsis, and of course we'll link to that so people could watch the whole talk. But I think that Mucin-1 or MUC1, as you call it, discovery is really important to kind of ground our discussion.A Mysterious Kidney Disease Unraveled Anna Greka (01:59):Oh, absolutely. Yeah, it's an interesting story. In some ways, in my TED Talk, I highlight one of the important families of this story, a family from Utah, but there's also other important families that are also part of the story. And this is also what I spoke about in London when we were together, and this is really sort of a medical mystery that initially started on the Mediterranean island of Cyprus, where it was found that there were many families in which in every generation, several members suffered and ultimately died from what at the time was a mysterious kidney disease. This was more than 30 years ago, and it was clear that there was something genetic going on, but it was impossible to identify the gene. And then even with the advent of Next-Gen sequencing, this is what's so interesting about this story, it was still hard to find the gene, which is a little surprising.Anna Greka (02:51):After we were able to sequence families and identify monogenic mutations pretty readily, this was still very resistant. And then it actually took the firepower of the Broad Institute, and it's actually from a scientific perspective, an interesting story because they had to dust off the old-fashioned Sanger sequencing in order to get this done. But they were ultimately able to identify this mutation in a VNTR region of the MUC1 gene. The Mucin-1 gene, which I call a dark corner of the human genome, it was really, it's highly repetitive, very GC-rich. So it becomes very difficult to sequence through there with Next-Gen sequencing. And so, ultimately the mutation of course was found and it's a single cytosine insertion in a stretch of cytosines that sort of causes this frameshift mutation and an early stop codon that essentially results in a neoprotein like a toxic, what I call a mangled protein that sort of accumulates inside the kidney cells.Anna Greka (03:55):And that's where my sort of adventure began. It was Eric Lander's group, who is the founding director of the Broad who discovered the mutation. And then through a conversation we had here in Boston, we sort of discovered that there was an opportunity to collaborate and so that's how I came to the Broad, and that's the beginnings of this story. I think what's fascinating about this story though, that starts in a remote Mediterranean island and then turns out to be a disease that you can find in every continent all over the world. There are probably millions of patients with kidney disease in whom we haven't recognized the existence of this mutation. What's really interesting about it though is that what we discovered is that the mangled protein that's a result of this misspelling of this mutation is ultimately captured by a family of cargo receptors, they're called the TMED cargo receptors and they end up sort of grabbing these misfolded proteins and holding onto them so tight that it's impossible for the cell to get rid of them.Anna Greka (04:55):And they become this growing heap of molecular trash, if you will, that becomes really hard to manage, and the cells ultimately die. So in the process of doing this molecular sleuthing, as I call it, we actually also identified a small molecule that actually disrupts these cargo receptors. And as I described in my TED Talk, it's a little bit like having these cargo trucks that ultimately need to go into the lysosome, the cells recycling facility. And this is exactly what this small molecule can do. And so, it was just like a remarkable story of discovery. And then I think the most exciting of all is that these cargo receptors turn out to be not only relevant to this one mangled misshapen protein, but they actually handle a completely different misshapen protein caused by a different genetic mutation in the eye, causing retinitis pigmentosa, a form of blindness, familial blindness. We're now studying familial Alzheimer's disease that's also involving these cargo receptors, and there are other mangled misshapen proteins in the liver, in the lung that we're now studying. So this becomes what I call a node, like a nodal mechanism that can be targeted for the benefit of many more patients than we had previously thought possible, which has been I think, the most satisfying part about this story of molecular sleuthing.Eric Topol (06:20):Yeah, and it's pretty extraordinary. We'll put the figure from your classic Cell paper in 2019, where you have a small molecule that targets the cargo receptor called TMED9.Anna Greka (06:34):Correct.Expanding the MissionEric Topol (06:34):And what's amazing about this, of course, is the potential to reverse this toxic protein disease. And as you say, it may have applicability well beyond this MUC1 kidney story, but rather eye disease with retinitis pigmentosa and the familial Alzheimer's and who knows what else. And what's also fascinating about this is how, as you said, there were these limited number of families with the kidney disease and then you found another one, uromodulin. So there's now, as you say, thousands of families, and that gets me to part of your sleuth work is not just hardcore science. You started an entity called the Ladders to Cures (L2C) Scientific Accelerator.Eric Topol (07:27):Maybe you can tell us about that because this is really pulling together all the forces, which includes the patient advocacy groups, and how are we going to move forward like this?Anna Greka (07:39):Absolutely. I think the goal of the Ladders to Cures Accelerator, which is a new initiative that we started at the Broad, but it really encompasses many colleagues across Boston. And now increasingly it's becoming sort of a national, we even have some international collaborations, and it's only two years that it's been in existence, so we're certainly in a growth mode. But the inspiration was really some of this molecular sleuthing work where I basically thought, well, for starters, it cannot be that there's only one molecular node, these TMED cargo receptors that we discovered there's got to be more, right? And so, there's a need to systematically go and find more nodes because obviously as anyone who works in rare genetic diseases will tell you, the problem for all of us is that we do what I call hand to hand combat. We start with the disease with one mutation, and we try to uncover the mechanism and then try to develop therapies, and that's wonderful.Anna Greka (08:33):But of course, it's slow, right? And if we consider the fact that there are 30 million patients in the United States in every state, everywhere in the country who suffer from a rare genetic disease, most of them, more than half of them are children, then we can appreciate the magnitude of the problem. Out of more than 8,000 genes that are involved in rare genetic diseases, we barely have something that looks like a therapy for maybe 500 of them. So there's a huge mismatch in the unmet need and magnitude of the problem. So the Ladders to Cures Accelerator is here to address this and to do this with the most modern tools available. And to your point, Eric, to bring patients along, not just as the recipients of whatever we discover, but also as partners in the research enterprise because it's really important to bring their perspectives and of course their partnerships in things like developing appropriate biomarkers, for example, for what we do down the road.Anna Greka (09:35):But from a fundamental scientific perspective, this is basically a project that aims to identify every opportunity for nodes, underlying all rare genetic diseases as quickly as possible. And this was one of the reasons I was there at the AI for Science Forum, because of course when one undertakes a project in which you're basically, this is what we're trying to do in the Ladders to Cures Accelerator, introduce dozens of thousands of missense and nonsense human mutations that cause genetic diseases, simultaneously introduce them into multiple human cells and then use modern scalable technology tools. Things like CRISPR screens, massively parallel CRISPR screens to try to interrogate all of these diseases in parallel, identify the nodes, and then develop of course therapeutic programs based on the discovery of these nodes. This is a massive data generation project that is much needed and in addition to the fact that it will help hopefully accelerate our approach to all rare diseases, genetic diseases. It is also a highly controlled cell perturbation dataset that will require the most modern tools in AI, not only to extract the data and understand the data of this dataset, but also because this, again, an extremely controlled, well controlled cell perturbation dataset can be used to train models, train AI models, so that in the future, and I hope this doesn't sound too futuristic, but I think that we're all aiming for that cell biologists for sure dream of this moment, I think when we can actually have in silico the opportunity to make predictions about what cell behaviors are going to look like based on a new perturbation that was not in the training set. So an experiment that hasn't yet been done on a cell, a perturbation that has not been made on a human cell, what if like a new drug, for example, or a new kind of perturbation, a new chemical perturbation, how would it affect the behavior of the cell? Can we make a predictive model for that? This doesn't exist today, but I think this is something, the cell prediction model is a big question for biology for the future. And so, I'm very energized by the opportunity to both address this problem of rare monogenic diseases that remains an unmet need and help as many patients as possible while at the same time advancing biology as much as we possibly can. So it's kind of like a win-win lifting all boats type of enterprise, hopefully.Eric Topol (12:11):Yeah. Well, there's many things to get to unpack what you've just been reviewing. So one thing for sure is that of these 8,000 monogenic diseases, they have relevance to the polygenic common diseases, of course. And then also the fact that the patient family advocates, they are great at scouring the world internet, finding more people, bringing together communities for each of these, as you point out aptly, these rare diseases cumulatively are high, very high proportion, 10% of Americans or more. So they're not so rare when you think about the overall.Anna Greka (12:52):Collectively.Help From the Virtual Cell?Eric Topol (12:53):Yeah. Now, and of course is this toxic proteinopathies, there's at least 50 of these and the point that people have been thinking until now that, oh, we found a mangled protein, but what you've zeroed in on is that, hey, you know what, it's not just a mangled protein, it's how it gets stuck in the cell and that it can't get to the lysosome to get rid of it, there's no waste system. And so, this is such fundamental work. Now that gets me to the virtual cell story, kind of what you're getting into. I just had a conversation with Charlotte Bunne and Steve Quake who published a paper in December on the virtual cell, and of course that's many years off, but of course it's a big, bold, ambitious project to be able to say, as you just summarized, if you had cells in silico and you could do perturbations in silico, and of course they were validated by actual experiments or bidirectionally the experiments, the real ones helped to validate the virtual cell, but then you could get a true acceleration of your understanding of cell biology, your field of course.Anna Greka (14:09):Exactly.Eric Topol (14:12):So what you described, is it the same as a virtual cell? Is it kind of a precursor to it? How do you conceive this because this is such a complex, I mean it's a fundamental unit of life, but it's also so much more complex than a protein or an RNA because not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions. So this is a bold challenge, right?Anna Greka (14:41):Oh my god, it's absolutely from a biologist perspective, it's the challenge of a generation for sure. We think taking humans to Mars, I mean that's an aspirational sort of big ambitious goal. I think this is the, if you will, the Mars shot for biology, being able to, whether the terminology, whether you call it a virtual cell. I like the idea of saying that to state it as a problem, the way that people who think about it from a mathematics perspective for example, would think about it. I think stating it as the cell prediction problem appeals to me because it actually forces us biologists to think about setting up the way that we would do these cell perturbation data sets, the way we would generate them to set them up to serve predictions. So for example, the way that I would think about this would be can I in the future have so much information about how cell perturbations work that I can train a model so that it can predict when I show it a picture of another cell under different conditions that it hasn't seen before, that it can still tell me, ah, this is a neuron in which you perturbed the mitochondria, for example, and now this is sort of the outcome that you would expect to see.Anna Greka (16:08):And so, to be able to have this ability to have a model that can have the ability to predict in silico what cells would look like after perturbation, I think that's sort of the way that I think about this problem. It is very far away from anything that exists today. But I think that the beginning starts, and this is one of the unique things about my institute, if I can say, we have a place where cell biologists, geneticists, mathematicians, machine learning experts, we all come together in the same place to really think and grapple with these problems. And of course we're very outward facing, interacting with scientists all across the world as well. But there's this sort of idea of bringing people into one institute where we can just think creatively about these big aspirational problems that we want to solve. I think this is one of the unique things about the ecosystem at the Broad Institute, which I'm proud to be a part of, and it is this kind of out of the box thinking that will hopefully get us to generate the kinds of data sets that will serve the needs of building these kinds of models with predictive capabilities down the road.Anna Greka (17:19):But as you astutely said, AlphaFold of course was based on the protein database existing, right? And that was a wealth of available information in which one could train models that would ultimately be predictive, as we have seen this miracle that Demi Hassabis and John Jumper have given to humanity, if you will.Anna Greka (17:42):But as Demis and John would also say, I believe is as I have discussed with them, in fact, the cell prediction problem is really a bigger problem because we do not have a protein data bank to go to right now, but we need to create it to generate these data. And so, my Ladders to Cures Accelerator is here to basically provide some part of the answer to that problem, create this kind of well-controlled database that we need for cell perturbations, while at the same time maximizing our learnings about these fully penetrant coding mutations and what their downstream sequelae would be in many different human cells. And so, in this way, I think we can both advance our knowledge about these monogenic diseases, build models, hopefully with predictive capabilities. And to your point, a lot of what we will learn about this biology, if we think that it involves 8,000 or more out of the 20,000 genes in our genome, it will of course serve our understanding of polygenic diseases ultimately as well as we go deeper into this biology and we look at the combinatorial aspects of what different mutations do to human cells. And so, it's a huge aspirational problem for a whole generation, but it's a good one to work on, I would say.Learning the Language of Life with A.I. Eric Topol (19:01):Oh, absolutely. Now I think you already mentioned something that's quite, well, two things from what you just touched on. One of course, how vital it is to have this inner or transdisciplinary capability because you do need expertise across these vital areas. But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that, but it's not. Of course, as you mentioned, we have genome editing which allows to look at lots of different genome perturbations, like the single letter change that you found in MUC1 pathogenic critical mutation. There's also the AI world which is blossoming like I've never seen. In fact, I had in Science this week about learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human cell.Eric Topol (20:14):So this is exploding. As you said, the expertise in computer science and then this whole idea that you could take these powerful tools and do as you said, which is the need to accelerate, we just can't sit around here when there's so much discovery work to be done with the scalability, even though it might take years to get to this artificial intelligence virtual cell, which I have to agree, everyone in biology would say that's the holy grail. And as you remember at our conference in London, Demi Hassabis said that's what we'd like to do now. So it has the attention of leaders in AI around the world, obviously in the science and the biomedical community like you and many others. So it is an extraordinary time where we just can't sit still with these tools that we have, right?Anna Greka (21:15):Absolutely. And I think this is going to be, you mentioned the ASCI presidency in the beginning of our call. This is going to be the president gets to give an address at the annual meeting in Chicago. This is going to be one of the points I make, no matter what field in biomedicine we're in, we live in, I believe, a golden era and we have so many tools available to us that we can really accelerate our ability to help more patients. And of course, this is our mandate, the most important stakeholders for everything that we do as physician-scientists are our patients ultimately. So I feel very hopeful for the future and our ability to use these tools and to really make good on the promise of research is a public good. And I really hope that we can advance our knowledge for the benefit of all. And this is really an exciting time, I think, to be in this field and hopefully for the younger colleagues a time to really get excited about getting in there and getting involved and asking the big questions.Career ReflectionsEric Topol (22:21):Well, you are the prototype for this and an inspiration to everyone really, I'm sure to your lab group, which you highlighted in the TED Talk and many other things that you do. Now I want to spend a little bit of time about your career. I think it's fascinating that you grew up in Greece and your father's a nephrologist and your mother's a pathologist. So you had two physicians to model, but I guess you decided to go after nephrology, which is an area in medicine that I kind of liken it to Rodney Dangerfield, he doesn't get any respect. You don't see many people that go into nephrology. But before we get to your decision to do that somehow or other you came from Greece to Harvard for your undergrad. How did you make that connect to start your college education? And then subsequently you of course you stayed in Boston, you've never left Boston, I think.Anna Greka (23:24):I never left. Yeah, this is coming into 31 years now in Boston.Anna Greka (23:29):Yeah, I started as a Harvard undergraduate and I'm now a full professor. It's kind of a long, but wonderful road. Well, actually I would credit my parents. You mentioned that my father, they're both physician-scientists. My father is now both retired, but my father is a nephrologist, and my mother is a pathologist, actually, they were both academics. And so, when we were very young, we lived in England when my parents were doing postdoctoral work. That was actually a wonderful gift that they gave me because I became bilingual. It was a very young age, and so that allowed me to have this advantage of being fluent in English. And then when we moved back to Greece where I grew up, I went to an American school. And from that time, this is actually an interesting story in itself. I'm very proud of this school.Anna Greka (24:22):It's called Anatolia, and it was founded by American missionaries from Williams College a long time ago, 150 and more years ago. But it is in Thessaloniki, Greece, which is my hometown, and it's a wonderful institution, which gave me a lot of gifts as well, preparing me for coming to college in the United States. And of course, I was a good student in high school, but what really was catalytic was that I was lucky enough to get a scholarship to go to Harvard. And that was really, you could say the catalyst that propelled me from a teenager who was dreaming about a career as a physician-scientist because I certainly was for as far back as I remember in fact. But then to make that a reality, I found myself on the Harvard campus initially for college, and then I was in the combined Harvard-MIT program for my MD PhD. And then I trained in Boston at Mass General in Brigham, and then sort of started my academic career. And that sort of brings us to today, but it is an unlikely story and one that I feel still very lucky and blessed to have had these opportunities. So for sure, it's been wonderful.Eric Topol (25:35):We're the ones lucky that you came here and set up shop and you did your productivity and discovery work and sleuthing has been incredible. But I do think it's interesting too, because when you did your PhD, it was in neuroscience.Anna Greka (25:52):Ah, yes. That's another.Eric Topol (25:54):And then you switch gears. So tell us about that?Anna Greka (25:57):This is interesting, and actually I encourage more colleagues to think about it this way. So I have always been driven by the science, and I think that it seems a little backward to some people, but I did my PhD in neuroscience because I was interested in understanding something about these ion channels that were newly discovered at the time, and they were most highly expressed in the brain. So here I was doing work in the brain in the neuroscience program at Harvard, but then once I completed my PhD and I was in the middle of my residency training actually at Mass General, I distinctly remember that there was a paper that came out that implicated the same family of ion channels that I had spent my time understanding in the brain. It turned out to be a channelopathy that causes kidney disease.Anna Greka (26:43):So that was the light bulb, and it made me realize that maybe what I really wanted to do is just follow this thread. And my scientific curiosity basically led me into studying the kidney and then it seemed practical therefore to get done with my clinical training as efficiently as possible. So I finished residency, I did nephrology training, and then there I was in the lab trying to understand the biology around this channelopathy. And that sort of led us into the early projects in my young lab. And in fact, it's interesting we didn't talk about that work, but that work in itself actually has made it all the way to phase II trials in patients. This was a paper we published in Science in 2017 and follow onto that work, there was an opportunity to build this into a real drug targeting one of these ion channels that has made it into phase II trials. And we'll see what happens next. But it's this idea of following your scientific curiosity, which I also talked about in my TED Talk, because you don't know to what wonderful places it will lead you. And quite interestingly now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye in brain. So I tell people, do not limit yourself to whatever someone says your field is or should be. Just follow your scientific curiosity and usually that takes you to a lot more interesting places. And so, that's certainly been a theme from my career, I would say.Eric Topol (28:14):No, I think that's perfect. Curiosity driven science is not the term. You often hear hypothesis driven or now with AI you hear more AI exploratory science. But no, that's great. Now I want to get a little back to the AI story because it's so fascinating. You use lots of different types of AI such as cellular imaging would be fusion models and drug discovery. I mean, you've had drug discovery for different pathways. You mentioned of course the ion channel and then also as we touched on with your Cell paper, the whole idea of targeting the cargo receptor with a small molecule and then things in between. You discussed this of course at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state-of-the-art science that you're doing?Anna Greka (29:17):Sure, yeah, thank you. I think there are many ways in which even for quite a long time before AI became such a well-known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time. And so, this is actually a form of AI that we use in order to process millions of images. My lab has by produced probably more than 20 million images over the last few years, maybe five to six years. And so, if you can imagine it's impossible for any human to process this many images and make sense of them. So of course, we've been using machine learning that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.Anna Greka (30:06):And so, there's multiple different kinds of perturbations that we do to cells, whether we're using CRISPR or base editing to make, for example, genome wide or genome scale perturbations or small molecules as we have done as well in the past. These are all ways in which we are then using machine learning to read out the effects in images of cells that we're looking at. So that's one way in which machine learning is used in our daily work, of course, because we study misshape and mangled proteins and how they are recognized by these cargo receptors. We also use AlphaFold pretty much every day in my lab. And this has been catalytic for us as a tool because we really are able to accelerate our discoveries in ways that were even just three or four years ago, completely impossible. So it's been incredible to see how the young people in my lab are just so excited to use these tools and they're becoming extremely savvy in using these tools.Anna Greka (31:06):Of course, this is a new generation of scientists, and so we use AlphaFold all the time. And this also has a lot of implications of course for some of the interventions that we might think about. So where in this cargo receptor complex that we study for example, might we be able to fit a drug that would disrupt the complex and lead the cargo tracks into the lysosome for degradation, for example. So there's many ways in which AI can be used for all of these functions. So I would say that if we were to organize our thinking around it, one way to think about the use of machine learning AI is around what I would call understanding biology in cells and what in sort of more kind of drug discovery terms you would call target identification, trying to understand the things that we might want to intervene on in order to have a benefit for disease.Anna Greka (31:59):So target ID is one area in which I think machine learning and AI will have a catalytic effect as they already are. The other of course, is in the actual development of the appropriate drugs in a rational way. So rational drug design is incredibly enabled by AlphaFold and all these advances in terms of understanding protein structures and how to fit drugs into them of all different modalities and kinds. And I think an area that we are not yet harnessing in my group, but I think the Ladders to Cures Accelerator hopes to build on is really patient data. I think that there's a lot of opportunity for AI to be used to make sense of medical records for example and how we extract information that would tell us that this cohort of patients is a better cohort to enroll in your trial versus another. There are many ways in which we can make use of these tools. Not all of them are there yet, but I think it's an exciting time for being involved in this kind of work.Eric Topol (32:58):Oh, no question. Now it must be tough when you know the mechanism of these families disease and you even have a drug candidate, but that it takes so long to go from that to helping these families. And what are your thoughts about that, I mean, are you thinking also about genome editing for some of these diseases or are you thinking to go through the route of here's a small molecule, here's the tox data in animal models and here's phase I and on and on. Where do you think because when you know so much and then these people are suffering, how do you bridge that gap?Anna Greka (33:39):Yeah, I think that's an excellent question. Of course, having patients as our partners in our research is incredible as a way for us to understand the disease, to build biomarkers, but it is also exactly creating this kind of emotional conflict, if you will, because of course, to me, honesty is the best policy, if you will. And so, I'm always very honest with patients and their families. I welcome them to the lab so they can see just how long it takes to get some of these things done. Even today with all the tools that we have, of course there are certain things that are still quite slow to do. And even if you have a perfect drug that looks like it fits into the right pocket, there may still be some toxicity, there may be other setbacks. And so, I try to be very honest with patients about the road that we're on. The small molecule path for the toxic proteinopathies is on its way now.Anna Greka (34:34):It's partnered with a pharmaceutical company, so it's on its way hopefully to patients. Of course, again, this is an unpredictable road. Things can happen as you very well know, but I'm at least glad that it's sort of making its way there. But to your point, and I'm in an institute where CRISPR was discovered, and base editing and prime editing were discovered by my colleagues here. So we are in fact looking at every other modality that could help with these diseases. We have several hurdles to overcome because in contrast to the liver and the brain, the kidney for example, is not an organ in which you can easily deliver nucleic acid therapies, but we're making progress. I have a whole subgroup within the bigger group who's focusing on this. It's actually organized in a way where they're running kind of independently from the cell biology group that I run.Anna Greka (35:31):And it's headed by a person who came from industry so that she has the opportunity to really drive the project the way that it would be run milestone driven, if you will, in a way that it would be run as a therapeutics program. And we're really trying to go after all kinds of different nucleic acid therapies that would target the mutations themselves rather than the cargo receptors. And so, there's ASO and siRNA technologies and then also actual gene editing technologies that we are investigating. But I would say that some of them are closer than others. And again, to your question about patients, I tell them honestly when a project looks to be more promising, and I also tell them when a project looks to have hurdles and that it will take long and that sometimes I just don't know how long it will take before we can get there. The only thing that I can promise patients in any of our projects, whether it's Alzheimer's, blindness, kidney disease, all I can promise is that we're working the hardest we possibly can on the problem.Anna Greka (36:34):And I think that is often reassuring I have found to patients, and it's best to be honest about the fact that these things take a long time, but I do think that they find it reassuring that someone is on it essentially, and that there will be some progress as we move forward. And we've made progress in the very first discovery that came out of my lab. As I mentioned to you, we've made it all the way to phase II trials. So I have seen the trajectory be realized, and I'm eager to make it happen again and again as many times as I can within my career to help as many people as possible.The Paucity of Physician-ScientistsEric Topol (37:13):I have no doubts that you'll be doing this many times in your career. No, there's no question about it. It's extraordinary actually. There's a couple of things there I want to pick up on. Physician-scientists, as you know, are a rarefied species. And you have actually so nicely told the story about when you have a physician-scientist, you're caring for the patients that you're researching, which is, most of the time we have scientists. Nothing wrong with them of course, but you have this hinge point, which is really important because you're really hearing the stories and experiencing the patients and as you say, communicating about the likelihood of being able to come up with a treatment or the progress. What are we going to do to get more physician-scientists? Because this is a huge problem, it has been for decades, but the numbers just keep going lower and lower.Anna Greka (38:15):I think you're absolutely right. And this is again, something that in my leadership of the ASCI I have made sort of a cornerstone of our efforts. I think that it has been well-documented as a problem. I think that the pressures of modern clinical care are really antithetical to the needs of research, protected time to really be able to think and be creative and even have the funding available to be able to pursue one's program. I think those pressures are becoming so heavy for investigators that many of them kind of choose one or the other route most often the clinical route because that tends to be, of course where they can support their families better. And so, this has been kind of the conundrum in some ways that we take our best and brightest medical students who are interested in investigation, we train them and invest in them in becoming physician-scientists, but then we sort of drop them at the most vulnerable time, which is usually after one completes their clinical and scientific training.Anna Greka (39:24):And they're embarking on early phases of one's careers. It has been found to be a very vulnerable point when a lot of people are now in their mid-thirties or even late thirties perhaps with some family to take care of other burdens of adulthood, if you will. And I think what it becomes very difficult to sustain a career where one salary is very limited due to the research component. And so, I think we have to invest in our youngest people, and it is a real issue that there's no good mechanism to do that at the present time. So I was actually really hoping that there would be an opportunity with leadership at the NIH to really think about this. It's also been discussed at the level of the National Academy of Medicine where I had some role in discussing the recent report that they put out on the biomedical enterprise in the United States. And it's kind of interesting to see that there is a note made there about this issue and the fact that there needs to be, I think, more generous investment in the careers of a few select physician-scientists that we can support. So if you look at the numbers, currently out of the entire physician workforce, a physician-scientist comprised of less than 1%.Anna Greka (40:45):It's probably closer to 0.8% at this point.Eric Topol (40:46):No, it's incredible.Anna Greka (40:48):So that's really not enough, I think, to maintain the enterprise and if you will, this incredible innovation economy that the United States has had this miracle engine, if you will, in biomedicine that has been fueled in large part by physician investigators. Of course, our colleagues who are non-physician investigators are equally important partners in this journey. But we do need a few of the physician-scientists investigators I think as well, if you really think about the fact that I think 70% of people who run R&D programs in all the big pharmaceutical companies are physician-scientists. And so, we need people like us to be able to work on these big problems. And so, more investment, I think that the government, the NIH has a role to play there of course. And this is important from both an economic perspective, a competition perspective with other nations around the world who are actually heavily investing in the physician-scientist workforce.Anna Greka (41:51):And I think it's also important to do so through our smaller scale efforts at the ASCI. So one of the things that I have been involved in as a council member and now as president is the creation of an awards program for those early career investigators. So we call them the Emerging-Generation Awards, and we also have the Young Physician-Scientist Awards. And these are really to recognize people who are making that transition from being kind of a trainee and a postdoc and have finished their clinical training into becoming an independent assistant professor. And so, those are small awards, but they're kind of a symbolic tap on the shoulder, if you will, that the ASCI sees you, you're talented, stay the course. We want you to become a future member. Don't give up and please keep on fighting. I think that can take us only so far.Anna Greka (42:45):I mean, unless there's a real investment, of course still it will be hard to maintain people in the pipeline. But this is just one way in which we have tried to, these programs that the ASCI offers have been very successful over the last few years. We create a cohort of investigators who are clearly recognized by members of the ASCI is being promising young colleagues. And we give them longitudinal training as part of a cohort where they learn about how to write a grant, how to write a paper, leadership skills, how to run a lab. And they're sort of like a buddy system as well. So they know that they're in it together rather than feeling isolated and struggling to get their careers going. And so, we've seen a lot of success. One way that we measure that is conversion into an ASCI membership. And so, we're encouraged by that, and we hope that the program can continue. And of course, as president, I'm going to be fundraising for that as well, it's part of the role. But it is a really worthy cause because to your point, we have to somehow make sure that our younger colleagues stay the course that we can at least maintain, if not bolster our numbers within the scientific workforce.Eric Topol (43:57):Well, you outlined some really nice strategies and plans. It's a formidable challenge, of course. And we'd like to see billions of dollars to support this. And maybe someday we will because as you say, if we could relieve the financial concerns of people who have curiosity driven ideas.Anna Greka (44:18):Exactly.Eric Topol (44:19):We could do a lot to replenish and build a big physician-scientist workforce. Now, the last thing I want to get to, is you have great communication skills. Obviously, anybody who is listening or watching this.Eric Topol (44:36):Which is another really important part of being a scientist, no less a physician or the hybrid of the two. But I wanted to just go to the backstory because your TED Talk, which has been watched by hundreds of thousands of people, and I'm sure there's hundreds of thousands more that will watch it, but the TED organization is famous for making people come to the place a week ahead. This is Vancouver used to be in LA or Los Angeles area and making them rehearse the talk, rehearse, rehearse, rehearse, which seems crazy. You could train the people there, how to give a talk. Did you have to go through that?Anna Greka (45:21):Not really. I did rehearse once on stage before I actually delivered the talk live. And I was very encouraged by the fact that the TED folks who are of course very well calibrated, said just like that. It's great, just like that.Eric Topol (45:37):That says a lot because a lot of people that do these talks, they have to do it 10 times. So that kind of was another metric. But what I don't like about that is it just because these people almost have to memorize their talks from giving it so much and all this coaching, it comes across kind of stilted and unnatural, and you're just a natural great communicator added to all your other things.Anna Greka (46:03):I think it's interesting. Actually, I would say, if I may, that I credit, of course, I actually think that it's important, for us physician-scientists, again, science and research is a public good, and being able to communicate to the public what it is that we do, I think is kind of an obligation for the fact that we are funded by the public to do this kind of work. And so, I think that's important. And I always wanted to cultivate those communication skills for the benefit of communicating simply and clearly what it is that we do in our labs. But also, I would say as part of my story, I mentioned that I had the opportunity to attend a special school growing up in Greece, Anatolia, which was an American school. One of the interesting things about that is that there was an oratory competition.Anna Greka (46:50):I got very early exposure entering that competition. And if you won the first prize, it was in the kind of ancient Rome way, first among equals, right? And so, that was the prize. And I was lucky to have this early exposure. This is when I was 14, 15, 16 years old, that I was training to give these oratory speeches in front of an audience and sort of compete with other kids who were doing the same. I think these are just wonderful gifts that a school can give a student that have stayed with me for life. And I think that that's a wonderful, yeah, I credit that experience for a lot of my subsequent capabilities in this area.Eric Topol (47:40):Oh, that's fantastic. Well, this has been such an enjoyable conversation, Anna. Did I miss anything that we need to bring up, or do you think we have it covered?Anna Greka (47:50):Not at all. No, this was wonderful, and I thoroughly enjoyed it as well. I'm very honored seeing how many other incredible colleagues you've had on the show. It's just a great honor to be a part of this. So thank you for having me.Eric Topol (48:05):Well, you really are such a great inspiration to all of us in the biomedical community, and we'll be cheering for your continued success and thanks so much for joining today, and I look forward to the next time we get a chance to visit.Anna Greka (48:20):Absolutely. Thank you, Eric.**************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding and support for biomedical research at NIH and other US governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Internet scholar and activist Ethan Zuckerman is horrified by the American ban on TikTok. As a self-described “progressive” with a long and distinguished career advocating for internet freedom, Zuckerman expresses alarm at how the U.S. has moved from defending unfettered access to information in the 1960s to now being willing to ban popular Chinese platforms like TikTok and perhaps even DeepSeek. He suggests the ban stems from the anti-China hysteria and exaggerated fears about social media's impact on young people fueled by paranoid critics like Jonathan Haidt. If this trend toward online censorship continues, Zuckerman warns, America will become indistinguishable from other authoritarian states in its disdain for digital freedom. Here are the 5 KEEN ON takeaways from the interview with Zuckerman:* The TikTok ban represents a dramatic shift in American values - Zuckerman points out that the US has moved from defending unfettered access to information (even Communist propaganda) in 1965 to now being willing to ban popular platforms. He sees this as contradicting core First Amendment principles.* Anti-China sentiment and social media fears are driving policy - The push to ban TikTok stems from a combination of paranoia about Chinese influence and exaggerated concerns about social media's effects on youth. Zuckerman argues there's little evidence supporting claims of Chinese manipulation or widespread social media harm.* Young people view the TikTok ban as evidence of institutional disconnect - Students see the ban as proof that lawmakers don't understand modern technology or youth culture. Their response of moving to other Chinese platforms demonstrates their cynicism toward government actions.* Social media platforms have become too powerful to easily abandon - Despite disagreeing with the politics of platforms like Facebook and X, users remain because of network effects. Zuckerman himself confesses to still using these platforms to maintain connections, even while advocating for alternatives.* "Middleware" could offer a solution - Rather than banning platforms or creating new ones, Zuckerman (like Frank Fukuyama) advocates for tools that let users modify how they interact with existing platforms. However, he warns, major platforms like Meta actively resist these efforts through legal threats and technical barriers.Ethan Zuckerman is an associate professor of public policy, communication, and information, as well as director of the UMass Initiative for Digital Public Infrastructure, focused on reimagining the Internet as a tool for civic engagement. His research focuses on civic media, online community governance, digital public infrastructure, quantitative studies of media attention, technology, and social change. Before coming to UMass, Zuckerman was at MIT, where he served as director of the Center for Civic Media and as associate professor of practice in media arts and sciences at the MIT Media Lab. His research focuses on the use of media as a tool for social change, the role of technology in international development, and the use of new media technologies by activists. The author of Rewire: Digital Cosmopolitans in the Age of Connection, he will publish a new book, Mistrust: Why Losing Faith in Institutions Provides the Tools to Transform Them (W.W. Norton), in early 2021. In 2005, Zuckerman cofounded Global Voices, which showcases news and opinions from citizen media in more than 150 nations and 30 languages. Through Global Voices, and as a researcher and fellow for eight years at the Berkman Klein Center for Internet and Society at Harvard University, Zuckerman has led efforts to promote freedom of expression and fight censorship in online spaces. In 1999, Zuckerman founded Geekcorps, an international, nonprofit, volunteer organization that sent IT specialists to work on projects in developing nations, with a focus on West Africa. Previously, he helped found Tripod.com, one of the web's first "personal publishing" sites. In addition to authoring numerous academic articles, Zuckerman is a frequent contributor to media outlets such as The Atlantic, Wired, and CNN. He received his bachelor's degree from Williams College and, as a Fulbright scholar, studied at the University of Ghana at Legon.Named as one of the "100 most connected men" by GQ magazine, Andrew Keen is amongst the world's best known broadcasters and commentators. In addition to presenting the daily KEEN ON show, he is the host of the long-running How To Fix Democracy interview series. He is also the author of four prescient books about digital technology: CULT OF THE AMATEUR, DIGITAL VERTIGO, THE INTERNET IS NOT THE ANSWER and HOW TO FIX THE FUTURE. Andrew lives in San Francisco, is married to Cassandra Knight, Google's VP of Litigation & Discovery, and has two grown children.Keen On is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit keenon.substack.com/subscribe

Send us a textFaith and public policy are at a crossroads, making waves in national headlines. This intersection is deeply political, with Christians divided on all sides of the issue. As followers of Christ, it's essential to remember that while Jesus' message is undeniably political, it is never partisan.In this episode, Bishop Wright sits down with Rebecca Linder Blachly, the Director of the Office of Government Relations for The Episcopal Church. Together, they explore the nation's most pressing issues and the critical role the Church plays in advocating for humane immigration policies amidst political tension. Rebecca, whose journey took her from studying philosophy to navigating the corridors of the Pentagon, offers her unique perspective on how to maintain hope and stability, all while nurturing existing ministries. Listen in for the full conversation.Since 2016, Rebecca Blachly has served as The Director of The Office of Government Relations for The Episcopal Church. Prior to this role, she was the Senior Policy Advisor for Africa in the Office of Religion and Global Affairs at the U.S. Department of State. Her previous positions include Acting Chief of the Strategic Communication Division at U.S. Africa Command in Stuttgart, Germany, Special Assistant to the Principal Deputy Under Secretary of Defense for Policy, and Research Associate in the Post-Conflict Reconstruction Project at the Center for Strategic and International Studies. She has conducted fieldwork and research throughout Africa and the Middle East and she has published on civil-military relations and information sharing in complex environments. Ms. Blachly received her B.A. in philosophy from Williams College and her M.Div. from Harvard University, and she is a Term Member at the Council on Foreign Relations.Support the show Follow us on IG and FB at Bishop Rob Wright.

  A successful tech entrepreneur Andre Shadowman was one of the first 30 Airbnb employees he built a successful career helping expand business internationally coordinating with him being on the floor of the New York Stock Exchange as the VP of international expansion at five or when they went public in 2019 he has a masters degree in public policy from Harvard Kennedy school ABA from Williams College of these accolades among others matter less to him now that he has a current dream of showing the magic and the power of human connection around the world born and raised in New Orleans to Argentine Jewish parents with a broader Colombian immigrant community Andreas currently travels the world nomadically with a Mexican Bates https://www.youtube.com/@SchabelmaniaBecome a supporter of this podcast: https://www.spreaker.com/podcast/inspiring-stories--2917948/support.

A new book by the Pulitzer Prize finalist Nicholas Carr is always a major event. And today's release of SUPERBLOOM: How Technologies of Connection Tear Us Apart offers a prescient critique of our social media age. As Carr explains, our assumption that more communication leads to better understanding is fundamentally wrong. Instead, he suggests that excessive communication through digital platforms actually tears people apart. Carr's use of the “Superbloom” metaphor refers to an actual 2019 event in Southern California where people flocked to photograph wildflowers for social media, trampling the actual flowers in pursuit of the perfect image. Carr uses this as a metaphor for how we increasingly experience reality through online media rather than directly. Carr challenges the idea that new communication technologies automatically bring people together, noting how previous innovations like the telegraph and telephone came with similar utopian promises that were never fulfilled. He argues that modern smartphones and social media have created an unprecedented environment where we're constantly connected and socializing, which conflicts with how humans evolved to interact in bounded, physical spaces. Rather than offering simple solutions, Carr advocates for more mindful technology use and speculates that future generations might reject constant digital connectivity in favor of more meaningful direct experiences.Nicholas Carr writes about the human consequences of technology. His books, including the Pulitzer Prize finalist The Shallows: What the Internet Is Doing to Our Brains and the forthcoming Superbloom: How Technologies of Connection Tear Us Apart, have been translated into more than twenty-five languages. He has recently been a visiting professor of sociology at Williams College, and earlier in his career he was executive editor of the Harvard Business Review. In 2015, he received the Neil Postman Award for Career Achievement in Public Intellectual Activity from the Media Ecology Association. He writes the Substack newsletter New Cartographies. A New York Times bestseller when it was first published in 2010 and now hailed as “a modern classic,” Carr's The Shallows remains a touchstone for debates on the internet's effects on our thoughts and perceptions. A second edition of The Shallows, updated with a new chapter, was published in 2020. Carr's 2014 book The Glass Cage: Automation and Us, which the New York Review of Books called a “chastening meditation on the human future,” examines the personal and social consequences of our ever growing dependency on computers, robots, and artificial intelligence. His latest book, Utopia Is Creepy, published in 2016, collects his best essays, blog posts, and other writings from the past dozen years. The collection is “by turns wry and revelatory,” wrote Discover. Carr is also the author of two other influential books, The Big Switch: Rewiring the World, from Edison to Google (2008), which the Financial Times called “the best read so far about the significance of the shift to cloud computing,” and Does IT Matter? (2004).Named as one of the "100 most connected men" by GQ magazine, Andrew Keen is amongst the world's best known broadcasters and commentators. In addition to presenting KEEN ON, he is the host of the long-running How To Fix Democracy show. He is also the author of four prescient books about digital technology: CULT OF THE AMATEUR, DIGITAL VERTIGO, THE INTERNET IS NOT THE ANSWER and HOW TO FIX THE FUTURE. Andrew lives in San Francisco, is married to Cassandra Knight, Google's VP of Litigation & Discovery, and has two grown children.Keen On is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit keenon.substack.com/subscribe

Join us as we sit down with Billy Thom, Head Boys Basketball Coach at Millbrook School, for an insightful discussion about prep school basketball, college recruitment, and holistic student development. We explore Billy's journey from being a student manager during Davidson's historic Elite Eight run with Steph Curry to building a unique basketball program that emphasizes both athletic excellence and personal growth.

fWotD Episode 2814: William Robinson Brown Welcome to Featured Wiki of the Day, your daily dose of knowledge from Wikipedia’s finest articles.The featured article for Friday, 17 January 2025 is William Robinson Brown.William Robinson "W. R." Brown (January 17, 1875 – August 4, 1955) was an American corporate officer of the Brown Company of Berlin, New Hampshire. He was also an influential Arabian horse breeder, the founder and owner of the Maynesboro Stud, and an authority on Arabian horses.After graduating from Williams College, Brown joined the family corporation, then known as the Berlin Mills Company, and became manager of the Woods Products Division, overseeing the company's woodlands and logging operations. He became an early advocate for sustainable forest management practices, was a member of the New Hampshire Forestry Commission from 1909 until 1952, and served on the boards of several forestry organizations. As chair of the Forestry Commission, Brown helped send sawmills to Europe during World War I to assist the war effort. He was influenced by the Progressive movement, instituting employee benefits such as company-sponsored care for injured workers that predated modern workers' compensation laws. A Republican, he served as a presidential elector for New Hampshire in 1924.Brown founded the Maynesboro Stud in 1912 with foundation bloodstock from some of the most notable American breeders of Arabian horses. He looked abroad for additional horses, particularly from the Crabbet Arabian Stud, and imported Arabian horses from England, France and Egypt. At its peak, Maynesboro was the largest Arabian horse breeding operation in the United States. In 1929, he wrote The Horse of the Desert, still considered an authoritative work on the Arabian breed. He served as President of the Arabian Horse Club of America from 1918 until 1939. Brown was a remount agent and had a special interest in promoting the use of Arabian horses by the U. S. Army Remount Service. To prove the abilities of Arabians, he organized and participated in a number of endurance races of up to 300 miles (480 km), which his horses won three times, retiring the U. S. Mounted Service Cup. This accomplishment occurred even though The Jockey Club donated $50,000 to the U. S. Army to buy Thoroughbreds that tried but failed to beat the Arabians. Brown's legacy as a horse breeder was significant. Today, the term "CMK", meaning "Crabbet/Maynesboro/Kellogg" is a label for specific lines of "Domestic" or "American-bred" Arabian horses, many of which descend from Brown's breeding program. In 2012, the Berlin and Coös County Historical Society held a 100th anniversary celebration of the stud's founding.Although Brown family members sold personal assets to keep the Brown Company afloat during the Great Depression, including Brown's dispersal of his herd of Arabian horses in 1933, the business went into receivership in 1934. Brown remained in charge of the Woods Division through the company's second bankruptcy filing in 1941. He retired from the company in 1943 and died of cancer in 1955. His final book, Our Forest Heritage, was published posthumously, and his innovations in forest management became industry standards.This recording reflects the Wikipedia text as of 00:30 UTC on Friday, 17 January 2025.For the full current version of the article, see William Robinson Brown on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm standard Geraint.

Join Ocean House owner and author Deborah Goodrich Royce for a conversation with author Jenny Jackson, who will discuss her New York Times bestselling novel Pineapple Street, new in paperback. About Pineapple Street: A New York Times bestseller | A Good Morning America Book Club Pick Darley, the eldest daughter in the well-connected old money Stockton family, followed her heart, trading her job and her inheritance for motherhood but giving up far too much in the process; Sasha, a middle-class New England girl, has married into the Brooklyn Heights family, and finds herself cast as the arriviste outsider; and Georgiana, the baby of the family, has fallen in love with someone she can't have, and must decide what kind of person she wants to be. Rife with the indulgent pleasures of life among New York's one-percenters, Pineapple Street is a smart, escapist novel that sparkles with wit. Full of recognizable, loveable—if fallible—characters, it's about the peculiar unknowability of someone else's family, the miles between the haves and have-nots, and the insanity of first love—all wrapped in a story that is a sheer delight. About Jenny Jackson: Jenny Jackson is a Vice President and Executive Editor at Alfred A. Knopf. A graduate of Williams College and the Columbia Publishing Course, she lives in Brooklyn Heights with her family. Pineapple Street is her first novel. For more information about author Jenny Jackson, visit penguinrandomhouse.com. For details on Deborah Goodrich Royce and the Ocean House Author Series, visit deborahgoodrichroyce.com

Alice Albright, CEO of the Millennium Challenge Corporation (MCC), joins Mike Shanley to discuss MCC's role in US foreign policy, key MCC accomplishments, future countries and sectors of work, and how organizations can partner with MCC. RESOURCES: - MCC LinkedIn: https://www.linkedin.com/company/millennium-challenge-corporation - MCC Instagram: https://www.instagram.com/mccgov/ - Doing Business with MCC: https://www.mcc.gov/work-with-us/mcc-business/ - MCC Business Forecast: https://www.mcc.gov/resources/doc/report-business-forecast/ - Procurements on sam.gov BIOGRAPHY: Alice P. Albright is the Chief Executive Officer of the Millennium Challenge Corporation where she provides strategic leadership and vision to the agency helping deliver on programmatic priorities. Ms. Albright has more than 30 years of international experience in the private, non-profit and public sectors. Prior to MCC, Ms. Albright served as the CEO of the Global Partnership for Education (GPE). As a political appointee of the Obama Administration, between 2009 and 2013, she was the Executive Vice President and Chief Operating Officer of the Export-Import Bank of the United States (Ex-Im Bank). Beforehand, she was the Chief Financial and Investment Officer for the Global Alliance for Vaccines and Immunizations (GAVI). Prior to working in international development and government, Ms. Albright was a banker focusing on emerging markets, working principally at J.P. Morgan. Ms. Albright has served on two G7 Gender Equality Advisory Councils, appointed first by the President of France for the 2019 G7 and subsequently by the Prime Minister of the United Kingdom for the 2021 G7. Additionally, she has served on the Boards of Williams College and Mercersburg Academy. Ms. Albright received her MIA from Columbia University's School of International and Public Affairs and her BA from Williams College. She is a Chartered Financial Analyst and a member of the Council on Foreign Relations. LEARN MORE Thank you for tuning into this episode of the Aid Market Podcast. You can learn more about working with USAID by visiting our homepage: Konektid International and AidKonekt. To connect with our team directly, message the host Mike Shanley on LinkedIn.

What Does it Mean to Love a Forest? Ethan Tapper, a forester author from Vermont draws from his work as a forester and from his bestselling book "How to Love a Forest: The Bittersweet Work of Tending a Changing World " to discuss what it means to care for forests and other ecosystems at this moment in time. Ethan Tapper will be speaking on the Williams College campus in Williamstown, Massachusetts on February 11.

Nicholas Carr has been amongst the most persistently prescient observers of the digital revolution over the last quarter century. Take, for example, his 2012 essay "The Arc of Innovation Bends Towards Decadence," which, in many ways, foresaw our current technological and social predicament. Carr's thesis was that technological innovation increasingly moves toward fulfilling self-indulgent desires rather than addressing fundamental human needs, following a pattern similar to Maslow's hierarchy of needs. Carr accurately predicted the shift from idealistic views of technology as tools for self-actualization to their current role in feeding narcissism and anxiety. The timing of his essay proved particularly significant, as 2012 marked a crucial turning point when smartphones became dominant and social media reached mass adoption. This period coincided with what social psychologists like Jonathan Haidt identify as the beginning of a sharp rise in anxiety and decline in self-confidence, especially among young people. Carr's insights extend to current debates about AI, where he sees a potentially "decadent" trend of outsourcing fundamental human activities like writing and thinking to machines. He frames this as part of a broader pattern where technology, instead of enhancing human capabilities (in the manner of Steve Jobs' "bicycle for the mind"), increasingly substitutes for them entirely. Most notably, Carr recognized early on that digital technologies, while promising connection and democratization, often trigger "our worst instincts." His analysis helps explain why, despite growing awareness of social media's negative effects, we remain unable to disentangle ourselves from these technologies - a phenomenon he describes as "mis-wanting." Essential stuff, as always, from the great Nick Carr.Nicholas Carr writes about the human consequences of technology. His books, including the Pulitzer Prize finalist The Shallows: What the Internet Is Doing to Our Brains and the forthcoming Superbloom: How Technologies of Connection Tear Us Apart, have been translated into more than twenty-five languages. He has recently been a visiting professor of sociology at Williams College, and earlier in his career he was executive editor of the Harvard Business Review. In 2015, he received the Neil Postman Award for Career Achievement in Public Intellectual Activity from the Media Ecology Association. He writes the Substack newsletter New Cartographies. A New York Times bestseller when it was first published in 2010 and now hailed as “a modern classic,” Carr's The Shallows remains a touchstone for debates on the internet's effects on our thoughts and perceptions. A second edition of The Shallows, updated with a new chapter, was published in 2020. Carr's 2014 book The Glass Cage: Automation and Us, which the New York Review of Books called a “chastening meditation on the human future,” examines the personal and social consequences of our ever growing dependency on computers, robots, and artificial intelligence. His latest book, Utopia Is Creepy, published in 2016, collects his best essays, blog posts, and other writings from the past dozen years. The collection is “by turns wry and revelatory,” wrote Discover. Carr is also the author of two other influential books, The Big Switch: Rewiring the World, from Edison to Google (2008), which the Financial Times called “the best read so far about the significance of the shift to cloud computing,” and Does IT Matter? (2004).Named as one of the "100 most connected men" by GQ magazine, Andrew Keen is amongst the world's best known broadcasters and commentators. In addition to presenting KEEN ON, he is the host of the long-running How To Fix Democracy show. He is also the author of four prescient books about digital technology: CULT OF THE AMATEUR, DIGITAL VERTIGO, THE INTERNET IS NOT THE ANSWER and HOW TO FIX THE FUTURE. Andrew lives in San Francisco, is married to Cassandra Knight, Google's VP of Litigation & Discovery, and has two grown children. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit keenon.substack.com/subscribe

Join us for an in-depth conversation with MJumbe Williams, a seasoned College Basketball Official and the visionary Owner of Legacy Pro Am. In this episode, we explore the fascinating world of basketball officiating, diving into what sparked MJumbe's passion for refereeing and the rigorous preparation it takes to excel in this role. I met Mjumbe at the Rose Bowl when I went to Pasadena to watch Ohio State take on Oregon. He happened to be sitting right next to us and that's where we made that connection. MJumbe shares the behind-the-scenes details of his career, from studying game film to building mutual respect with players, coaches, and fellow referees. We also delve into his unique experiences in the iconic Drew League, where he's been a fixture since age 14, and his time as a professional basketball player in Japan. Discover MJumbe's favorite stadiums, his long-term aspirations as an official, and the incredible journey that's shaped his basketball career. Whether you're a fan of the game, an aspiring referee, or just curious about the challenges of officiating at the highest levels, this episode is packed with insights you won't want to miss. Tune in now to get an insider's perspective on the game we all love! Follow Legacy Pro Am on Instagram and checkout what he has going on over there: https://www.instagram.com/legacyproam/  Make sure to hit that follow button here on the channel and help us get this channel popping!  #Referee #WomensBasketball #DrewLeague _____________________________ If you are a business owner, and you have heard about ClickFunnels, then you know the power it can have on your business!!  EVERYONE is always looking for a discount to ClickFunnels, and I have it for you right here!  https://www.imallin.com/?aff=5cbea6d0-1f1c-435e-bf6f-489c8a4ac116-1WzEwLDIwNTZdc  If you want to get ClickFunnels at a MAJOR discounted rate, then click the link above and you can literally SAVE HUNDREDS PER YEAR on the subscription!  Get it TODAY!   

Equitable biomarker testing access, including pharmacogenomics testing, is critical for patients to experience optimal medication therapy outcomes. Be sure to tune in to this episode of the Precision Health and PGX Podcast as Dr. Becky Winslow, Dr. Behnaz Sarrami, and Hilary Goeckner, Director of State & Local Campaigns - Access to Care of the American Cancer Society Cancer Action Network (ACS CAN), educate listeners about ACS CAN's mission, how it executes on its mission, accomplishments, and future goals.  This episode is a must listen for anyone who wants the latest update on the American Cancer Society Cancer Action Network's work influencing state legislatures to pass legislation to expand coverage of biomarker testing, states who have already passed legislation and those with pending legislation, and to learn how they too can advocate.   After listening to this episode, listeners will be able to describe biomarker testing's importance in healthcare; describe how the American Cancer Society Cancer Action Network is championing biomarker testing coverage legislation; name states that have passed biomarker testing legislation and those with pending legislation; know how one can contribute to the efforts to increase biomarker testing coverage. Hilary Gee Goeckner is director of state and local campaigns for the American Cancer Society Cancer Action Network (ACS CAN), the advocacy affiliate of the American Cancer Society. In this role she leads work with ACS CAN staff and coalition partners across the country to improve access to comprehensive biomarker testing, clinical trials, fertility preservation and other health care access issues. Prior to this role, Hilary served as the Kansas government relations director for ACS CAN. Before joining ACS CAN, Hilary served as director of health policy at Kansas Action for Children. She holds a bachelor's degree in anthropology and global health from Williams College and a master's degree in social work from Boston College. She lives in San Diego with her husband and two children. As the CEO of inGENEious RX Incorporated and pharmacogenomics subject matter expert, Dr. Becky Winslow has dedicated over a decade to providing innovative solutions for pharmacogenomics stakeholders. Her extensive experience also includes directing pharmacy operations and medication safety programs across diverse clinical settings, spanning retail, hospital, long-term care, and public health. Dr. Winslow is a passionate educator, training Doctors of Clinical Pharmacy to work with molecular testing stakeholders and serving as an advanced pharmacy practice preceptor for Manchester University's Master of Science in Pharmacogenomics Program. She hosts an evidence-based educational podcast, The Precision Health and PGx Podcast, which Welp Magazine recognized as the ninth most listened to genetics podcast globally. Her involvement with prominent organizations like the Clinical Pharmacogenetics Implementation Consortium and the National Council for Prescription Drug Programs (NCPDP) PGx Task Force speaks to her expertise and commitment. Dr. Winslow frequently presents at national conferences such as The Association for Molecular Pathology and holds degrees from Campbell University.  Behnaz Sarrami, PharmD, MS, is a leading expert in pharmacogenomics and a dedicated Medical Science Liaison (MSL). She is named American Pharmacists Association's (APhA) "50 Most Influential Leaders in Pharmacy" and Medika's "Top 30 Women Transforming Healthcare". Behnaz is passionate about advancing personalized medicine to optimize treatments and improve patient outcomes, especially in underserved populations. She supports healthcare professionals through scientific training and presentations. As the host of the "Precision Health and PGx" podcast, she mentors pharmacists transitioning into MSL roles and those launching pharmacogenomics consulting careers. She earned her Master's in Biochemistry from Georgetown University and her Doctorate in Pharmacy from Creighton University. With significant contributions to research and education, she continues to drive innovation in pharmacogenomics through her work with healthcare professionals and community outreach programs.  

Doug Williams, College and NFL Legend with Vincent and Harper Broadcasting live from Atlanta, GA since 2018 with hosts Vincent Turner, Harper LeBel, and producer Jeremiah Long. We are 100 Yards of Football. Live from Atlanta, Georgia! Visit us online many.link/100yardsoffootball Listen to the PODCAST daily: 100 Yards of Football https://many.link/100yardsoffootball, Want to create live streams like this? StreamYard: https://streamyard.com/pal/d/58362923...

Equitable biomarker testing access, including pharmacogenomics testing, is critical for patients to experience optimal medication therapy outcomes. Be sure to tune in to this episode of the Precision Health and PGX Podcast as Dr. Becky Winslow, Dr. Behnaz Sarrami, and Hilary Goeckner, Director of State & Local Campaigns - Access to Care of the American Cancer Society Cancer Action Network (ACS CAN), educate listeners about ACS CAN's mission, how it executes on its mission, accomplishments, and future goals.  This episode is a must listen for anyone who wants the latest update on the American Cancer Society Cancer Action Network's work influencing state legislatures to pass legislation to expand coverage of biomarker testing, states who have already passed legislation and those with pending legislation, and to learn how they too can advocate.   After listening to this episode, listeners will be able to describe biomarker testing's importance in healthcare; describe how the American Cancer Society Cancer Action Network is championing biomarker testing coverage legislation; name states that have passed biomarker testing legislation and those with pending legislation; know how one can contribute to the efforts to increase biomarker testing coverage. Hilary Gee Goeckner is director of state and local campaigns for the American Cancer Society Cancer Action Network (ACS CAN), the advocacy affiliate of the American Cancer Society. In this role she leads work with ACS CAN staff and coalition partners across the country to improve access to comprehensive biomarker testing, clinical trials, fertility preservation and other health care access issues. Prior to this role, Hilary served as the Kansas government relations director for ACS CAN. Before joining ACS CAN, Hilary served as director of health policy at Kansas Action for Children. She holds a bachelor's degree in anthropology and global health from Williams College and a master's degree in social work from Boston College. She lives in San Diego with her husband and two children. As the CEO of inGENEious RX Incorporated and pharmacogenomics subject matter expert, Dr. Becky Winslow has dedicated over a decade to providing innovative solutions for pharmacogenomics stakeholders. Her extensive experience also includes directing pharmacy operations and medication safety programs across diverse clinical settings, spanning retail, hospital, long-term care, and public health. Dr. Winslow is a passionate educator, training Doctors of Clinical Pharmacy to work with molecular testing stakeholders and serving as an advanced pharmacy practice preceptor for Manchester University's Master of Science in Pharmacogenomics Program. She hosts an evidence-based educational podcast, The Precision Health and PGx Podcast, which Welp Magazine recognized as the ninth most listened to genetics podcast globally. Her involvement with prominent organizations like the Clinical Pharmacogenetics Implementation Consortium and the National Council for Prescription Drug Programs (NCPDP) PGx Task Force speaks to her expertise and commitment. Dr. Winslow frequently presents at national conferences such as The Association for Molecular Pathology and holds degrees from Campbell University.  Behnaz Sarrami, PharmD, MS, is a leading expert in pharmacogenomics and a dedicated Medical Science Liaison (MSL). She is named American Pharmacists Association's (APhA) "50 Most Influential Leaders in Pharmacy" and Medika's "Top 30 Women Transforming Healthcare". Behnaz is passionate about advancing personalized medicine to optimize treatments and improve patient outcomes, especially in underserved populations. She supports healthcare professionals through scientific training and presentations. As the host of the "Precision Health and PGx" podcast, she mentors pharmacists transitioning into MSL roles and those launching pharmacogenomics consulting careers. She earned her Master's in Biochemistry from Georgetown University and her Doctorate in Pharmacy from Creighton University. With significant contributions to research and education, she continues to drive innovation in pharmacogenomics through her work with healthcare professionals and community outreach programs.  

Dr. Bruce Beehler is an ornithologist and Research Associate in the Bird Division of the Smithsonian Institution's National Museum of Natural History. Bruce's research is focused on the birds of the boreal conifer forests of the U.S. and Canada. He is interested in understanding how the permanent resident birds survive in these forests year round. Bruce spends much of his free time outside and immersed in nature. He enjoys playing tennis, going for hikes, and kayaking, as well as watching wildlife at the feeders outside his home. He completed his undergraduate studies in American Civilization at Williams College and received his Masters and PhD degrees in Biology from Princeton University where he studied behavioral ecology of the birds of paradise. Afterwards, Bruce worked for ten years at the Smithsonian's Natural Museum of Natural history. Before returning to the Museum in 2014, Bruce worked for Conservation International, the Wildlife Conservation Society, the U.S. Department of State, Counterpart International, and the National Fish and Wildlife Foundation. Bruce is a Fellow of the American Ornithologists Union, and he is the author of eleven books including a field guide and a taxonomic checklist of Birds of New Guinea and the recently released book North on the Wing. In our interview, Bruce shared some of his fantastic stories about life and science.

In this inspiring episode, we sit down with Montserrat Hidalgo, a recent high school graduate and environmental justice advocate. Montserrat shares her journey from Girl Scout Gold Award recipient to an emerging leader in her community. Learn how her project tackled urban heating and environmental racism in South East Los Angeles, the collaborative research that fueled her work, and the global connections she forged. About Our Guest: Montserrat Hidalgo is a recent graduate of South Gate High School and will be attending Williams College in the fall to double major in Environmental Studies and Biology. She has been a Girl Scout from 5th grade through 12th grade and completed her Gold Award by addressing urban heating and environmental racism in South East Los Angeles. As a passionate environmental justice advocate, Montserrat founded Youth Action!, an environmental justice club at her high school. She also collaborated with Communities for a Better Environment (cbecal.org), a statewide environmental justice organization, to conduct NASA-funded research with UC Irvine and Chapman University on hot spots, air quality, and green spaces in South East LA. This groundbreaking work not only laid the foundation for her Gold Award project but also connected her with a global network of changemakers. Key Takeaways from This Episode: The Inspiration: How Montserrat's experiences in South East LA motivated her to tackle environmental justice issues. The Gold Award Project: The impact of her work addressing urban heating and environmental racism and how it serves as a model for others. Youth Leadership: How she founded Youth Action! and collaborated with key organizations to make a difference. Actionable Advice: Tips for youth and community members looking to create meaningful environmental change. Links and Resources Mentioned in the Episode: Communities for a Better Environment: cbecal.org Learn more about the Girl Scout Gold Award: girlscouts.org/en/our-program/highest-awards/gold-award.html For more information about NASA-funded research: nasa.gov

Dance Talk” ® with Joanne Carey and special guest, Samantha Géracht, Artistic Director, Sokolow Theatre/Dane Ensemble. In this episode of Dance Talk, host Joanne Carey speaks with Samantha Géracht, the Artistic Director of Sokolow Theatre/Dance Ensemble. Together they discuss the influence of Anna Sokolow's work, the legacy of Anna Sokolow's immense catalogue of work and what an integral modern dance pioneer Sokolow is to the dance community. They also discuss the upcoming concert that emphasizes joy and light during the winter season. Samantha shares insights into her role as artistic director the growth of the company, the transformative experience of working with Sokolow's choreography, and the vision for the future of the company. Samantha Géracht performed with Anna Sokolow's Players' Project for eleven years and is a founding member of the Sokolow Theatre/Dance Ensemble. In 2017 Ms. Géracht was appointed the ensemble's artistic director. She has toured and taught Sokolow's repertory nationally and internationally, setting Ms. Sokolow's works on professional companies, university dance programs, and solo dance artists, including the Centre de Danse Nationale de Paris, the Boston Conservatory, Williams College, The Ailey School/Fordham University, Loyola Chicago, Franklin and Marshall College, Barnard College, Clarence Brooks, Jennifer Conely, Sandra Kaufman, Kanopy Dance Company and Academy, Ellen Robbins Dance, and Christine Dakin. Ms. Géracht studied technique and composition with Alwin Nikolais and Murry Louis, Humphrey/Limon with Jim May, Betty Jones, Fritz Luden, and Gail Corbin, and Weidman with Deborah Carr. She has taught in the Professional Studies program at the Limon Institute, the Herbert Berghoff (‘HB') Studio, and is on the faculty of the Hoboken Charter School. Ms. Geracht performed the Humphrey/Weidman repertory with Deborah Carr Theater Dance Ensemble and Gail Corbin. She has appeared with Rae Ballard's Thoughts in Motion, and as a guest artist with David Parker and The Bang Group. In 2016 she choreographed Shadowbox Theatre's The Earth and Me, a critically acclaimed climate change puppet/dance opera created for NYC public schools and community centers. Ms. Géracht served as a panelist for the Library of Congress opening of the “New Dance Group” archives. She holds an MFA in dance from Montclair State University (NJ) and a BS in dance from the University of Wisconsin-Madison. Ms. Géracht is committed to the preservation of early American Modern Dance, making the works of modern dance pioneers more accessible to dance education programs, young artists, and new audiences. https://sokolowtheatredance.org/ Upcoming Performance: JOY: Dances for Midwinter Choreography of Anna Sokolow, Charles Weidman, and Claudia Gitelman, set to the music of Scriabin, Rachmaninoff, Bach, and Schubert. December 12 & 13, 2024, 7:00 pm Stone Circle Theatre 59-14 70th Avenue, Ridgewood, New York 11385 Tickets: https://stonecircletheatre.org/ “Dance Talk” ® with Joanne Carey wherever you listen to your podcasts. ⁠⁠⁠⁠https://dancetalkwithjoannecarey.com/⁠⁠⁠⁠ Tune in. Follow. Like us. And Share. Please leave us review about our podcast! “Dance Talk” ® with Joanne Carey "Where the Dance World Connects, the Conversations Inspire, and Where We Are Keeping Them Real."

How do schools navigate the complexities of inclusion, polarization, and freedom of expression while fostering a vibrant learning environment? Today, John Austin, Head of School at Deerfield Academy, joins Heterodox Out Loud to explore these questions and share insights from the groundbreaking report, Thriving in a World of Pluralistic Contention: A Framework for Schools.John reflects on his unique journey from aspiring surfer to educational leader, shaping student experiences across continents, including his tenure at King's Academy in Jordan. Drawing from decades of experience, John delves into the challenges and opportunities presented by diversity in schools, discussing how institutions can promote dialogue, trust, and intellectual growth through structured initiatives like randomized community meals and robust expressive frameworks. John also sheds light on the collaborative process behind the report and its three foundational pillars: disciplined nonpartisanship, expressive freedom, and intellectual diversity.In This Episode:Independent schools as laboratories for educational innovationBalancing inclusivity with robust academic inquiryThe significance of Robert Putnam's social capital theoryStrategies for fostering meaningful dialogue across differencesThe transformative potential of conscientious, courageous, and tolerant expressionAbout John:Dr. John Austin became Deerfield Academy's 56th Head of School in July of 2019. Prior to Deerfield, Dr. Austin served as Headmaster at King's Academy in Madaba, Jordan, and before that as Academic Dean at St. Andrew's School in Middletown, Delaware, where he joined the faculty in 1987. A graduate of Williams College, he holds a Master of Arts, Master of Philosophy, and Doctoral degrees in English and Comparative Literature from Columbia University, along with a Master's degree from the Bread Loaf School of English at Middlebury College. Last year, with funding from an E.E. Ford Foundation grant, Dr. Austin convened a group of renowned independent school leaders from across the United States to develop a framework for enhancing the expressive freedom of students, fostering in them habits of curiosity and critical analysis, and preparing them to thrive in a world of pluralistic contention. The resulting work, authored by Dr. Austin, Thriving in a World of Pluralistic Contention: A Framework for Schools, was published in May of 2024. Follow Heterodox Academy on:Twitter: https://bit.ly/3Fax5DyFacebook: https://bit.ly/3PMYxfwLinkedIn: https://bit.ly/48IYeuJInstagram: https://bit.ly/46HKfUgSubstack: https://bit.ly/48IhjNF

 With guest Tamanna Rahman, a textile artist, clothes maker, and psychiatric nurse practitioner who integrates holistic mental health practices into her craft. Tamanna shares her journey, from her early love for textiles inspired by her grandmother to how COVID sparked her passion for sewing and embroidery and drove home that life doesn't have to look like it always has.She discusses her work, Slow Work Sewing, and where she teaches embroidery workshops that guide students in translating daily experiences and emotions into abstract mark-making and stitch . The conversation touches on the therapeutic benefits of repetitive, bilateral motions in craft, the importance of aligning lifestyle with seasonal and personal cycles, and the concept of living a life that honors one's creative soul. Tamanna also share her exciting future workshop ideas and tips on self-care, creativity, and the freedom to live a fulfilling life on one's own terms.Tamanna studied literature and social movements at Williams College, and completed her graduate training at Yale University. She is originally from Los Angeles, and currently splits her time between New Haven, CT and Newfoundland, Canada. Find her online on Instagram @slow.work.sewing or www.slowworksewing.com.tina@kinshiphandwork.com

Dave Paulsen, the current head coach for Holy Cross men's basketball team, joins this week's episode of @Notevend2 . Coach Paulsen has been coaching since the late 80's and has a ton of knowledge that he gives throughout the episode. Paulsen played basketball for @WilliamsCollege and would later lead Williams to the programs first, and only, National Championship. Paulsen finished his career coaching the Ephs with a 170-53 record- giving him the 2nd most wins in Williams basketball history. After a successful career at Williams, Paulsen moved on to coach at Bucknell University. In his first head coaching role at the Division 1 level, coach Paulsen won three Patriot League Coach of the Year awards ('11, '12 & '15). Under Paulsen, Bucknell became the first Patriot League team to win three consecutive regular season titles. Paulsen currently holds the highest winning percentage in Bucknell history (.588). A big part to Bucknell's success was the addition of future NBA player, Mike Muscala. Muscala was a two-time Patriot League POTY while competing against future NBA all-star CJ McCollum. Coach Paulsen left Bucknell after seven seasons (2008-15) to coach at George Mason University and Fordham University. Paulsen coached plenty of players that would eventually become successful professional players, including Tyler Kolek. In 2023, Paulsen took the head coaching job at Holy Cross; in his second year leading the Crusaders, he's led the program to wins over high major programs, and the teams first conference tournament win since 2019. The Crusaders are currently 5-4 with 4 more games until Patriot League play begins. Hear about Paulsen's 28-year successful career, his experience coaching future NBA players, and what went into the dominance his teams had at Williams and Bucknell. This episode is available wherever you listen to podcasts. Make sure to subscribe to the podcasts YouTube channel @Notevend2 for more sports content. Enjoy the episode! Sneak Peek- 00:00-00:24 Alfred/Utica Updates- 00:24-02:31 Intro- 02:31-08:37 Recap of Holy Cross' 3-0 Weekend, Buzzer Beater Win, Coaching Philosophy in Late Game Situations- 08:37-15:25 Playing at Williams College in the 80's, Coach Harry Sheehy's Impact- 15:25-18:30 Experience as GA at Michigan University, Staying Connected with MU Players- 18:30-22:52Relationship with Tobin Anderson- 22:52-27:25 Coaching at Williams College, Winning Dlll National Championship in '03, Coaching against Coach David Hixon- 27:25-39:46 Success at Bucknell, Elite Coaching Tree, Advice for Aspiring Coaches- 39:46-50:23 Recruiting Mike Muscala, Dominance in the Patriot League, Relationship with Muscala Today- 50:23-57:10 Break- 57:10-57:22 Recruiting/Coaching Tyler Kolek, Opinion on Players Transferring- 57:22-01:05:53 Regret not Recruiting Duncan Robinson, Taking Risks on Players- 01:05:53-01:11:50Expectations/Future for Holy Cross MBB- 01:11:50-01:15:21 Rapid Fire (Funniest Players, Theme Song(s), Most Memorable Year Coaching)- 01:15:21-01:20:42 Starting 5: Best Players Coached- 01:20:42-01:23:22 Outro- 01:23:22-01:24:20

On the next episode of The MisFitNation, host Rich LaMonica welcomes Jeff Nelligan, a renowned commentator in the world of American parenting and the author of the newly released 2nd edition of “Four Lessons from My Three Sons – How You Can Raise Resilient Kids.” In his book, Jeff shares his parenting techniques that guided his three sons through childhood and adolescence to prestigious institutions like the U.S. Naval Academy, Williams College, and West Point. Jeff's expertise has been featured on National Public Radio and in numerous parenting publications, including Parents Magazine and Fatherly. As a public affairs executive in Washington, D.C., Jeff brings a wealth of experience, having worked for three Members of Congress and served as a Presidential appointee. An Army veteran with Polynesian ancestry (Māori Indian, New Zealand), Jeff is also a graduate of Williams College and Georgetown University Law School. Don't miss this insightful conversation as Jeff delves into the principles of resilient parenting and how they can be applied in today's world. check out Jeff's site : www.NelliganBooks.com Support The MisFitNation To keep The MisFitNation thriving and to continue providing this platform, we welcome sponsorships and donations. Our sponsorship tiers are Red ($750), White ($500), and Blue ($250), each with unique perks. You can also donate monthly at any amount of your choosing at https://ko-fi.com/themisfitnationpodcast Follow us on all your favorite podcast apps and our socials: https://www.facebook.com/rich.lamonica/ https://www.facebook.com/MisFitnation.Podcast https://www.imstagram.com/the_misfitnation Twitter @richlamonica https://www.YouTube.com/@The_MisFitNation LinkedIn: https://www.linkedin.com/in/richlamonica Twitch: the_misfitnation https://www.themisfitnation.com #JeffNelligan #RaisingResilientKids #ParentingTips #MisFitNation #RichLaMonica #ResilientParenting #MilitaryFamily #ParentingAdvice #Fatherhood #FamilySuccess #ParentingBooks #USNavalAcademy #WilliamsCollege #WestPoint #GeorgetownLaw #ParentingPodcast #ArmyVeteran #PolynesianHeritage #WashingtonDC #PodcastInterview #ViralParenting #LeadershipInParenting Learn more about your ad choices. Visit megaphone.fm/adchoices

Despite heart disease being the leading cause of death in the United States, cardiovascular care has been an overlooked opportunity in digital health. With 1 in 3 Americans facing cardiovascular disease in their lifetime, how can innovation help turn the tide?In this episode, we explore heart health in the digital age with Dr. Jeff Wessler, cardiologist and founder/CEO of Heartbeat Health, the nation's largest virtual-first cardiovascular company.We cover:⌚If we can trust cardiovascular data from wearable devices (and what doctors call “Apple Heart Syndrome”)

Join host Tess Connolly, LCSW, for an insightful conversation with Jeff Nelligan who is the father of three boys and a well-known commentator in the world of American parenting. His most recent book is the 2nd edition of “Four Lessons from My Three Sons – How You Can Raise Resilient Kids,” in which he outlined his parenting techniques and the path of his sons through childhood and adolescence to the U.S. Naval Academy, Williams College, and West Point. ⭐  Discover how Jeff's life experiences and lessons as a father inspired him to write his parenting books. ⭐ Tess and Jeff explore the importance of having a parenting strategy and being intentional in your journey as a parent. ⭐ Hear Jeff's practical strategies for raising resilient kids and his thoughts on challenging societal norms in parenting.  ⭐ Learn about the four simple yet powerful attributes Jeff emphasizes: personal courtesy, sustained confidence, grinding resilience in adversity, and ambition. ⭐ Tess shares examples from her own parenting journey with her son and Jeff offers insights from raising his sons, highlighting how these values can be taught in different ways.  ⭐ Get insights on supporting children through challenges and helping them push past obstacles they face in life. ⭐ Tess and Jeff discuss ways to inspire ambition in children and nurture their drive for success. ⭐ Jeff is most grateful for his three sons and his strategy and his fortitude to keep to his strategy along the journey.  Find out more about Jeff Nelligan and purchase his book here

When was the last time you read for 30 minutes straight? Uninterrupted? Ramon Javier, Head of School at George Jackson Academy, joins Articulating to discuss the importance of literacy in academic success, developing empathy, and building critical thinking skills. Listen for strategies on how to foster a love for reading not only for your scholar but also yourself!  ABOUT RAMON Ramón is a lifelong New Yorker, proud of his Afro-Latinx roots. A member of Prep for Prep, Ramón graduated from The Hackley School, Williams College, and received his Ed.M from Teachers College, Columbia University. He worked for Prep for Prep, The TEAK Fellowship, KIPP, Packer Collegiate, and The Trinity School in a variety of leadership roles. He also served on the NYSAIS Diversity Committee for six years.  Ramón sits on the boards of the International Boys' Schools Coalition, the New York State Association of Independent Schools. He is also a  member of the Education Committee of the Grace Church School Board of Trustees and sits on the Advisory Board of Parents In Action. Ramón is in his third year as Head of School at George Jackson Academy. Follow us at @artic.ulating on IG for more of Articulating!

1982 - Florida, Massachusetts. On a rainy Saturday evening in April 1982, 18-year-old Lynn Burdick was working alone at the Barefoot Peddlar, a small country store in the Berkshires. By the end of her shift, she had vanished—along with the cash in the register. Known for her reliability, Lynn's disappearance immediately raised alarms. Less than an hour before she went missing, just 14 miles away at Williams College, a man attempted to kidnap a student in his car. Investigators couldn't help but question whether the two events were connected.  Though decades have passed without answers, there is renewed hope that someone will finally come forward with the key to bringing Lynn home. If you have information on the disappearance of Lynn Burdick, please contact the Berkshire State Police Detective Unit at 413-499-1112 or submit a tip to the FBI at tips.fbi.gov. Episode sources and photos: https://murdershetold.com/episodes/lynn-burdick Support the show: https://www.murdershetold.com/support Instagram: @murdershetoldpodcast TikTok: @murdershetold Facebook: /mstpodcast Website: murdershetold.com ----- Sponsors: Jenni Kayne: Get 15% off with code SHETOLD15 at jennikayne.com/SHETOLD15 Branch Basics: Get 15% off Branch Basics with the code SHETOLD at branchbasics.com/SHETOLD HoneyLove: Get 20% OFF at honeylove.com/SHETOLD Learn more about your ad choices. Visit megaphone.fm/adchoices

For Beyond 50's "Personal Growth" talks, listen to an interview with Jeff Nelligan. He is a dad of three military officer sons. He'll talk about his parenting strategies that helped his sons develop the character and savvy to propel them to the U.S. Naval Academy, Williams College, West Point and beyond. The four main lessons he taught them were developing personal conduct, a confident worldview, grinding resilience in adversity, and spurring ambition. According to him, about 75 percent of the time we spend with our children is over by the age of 12, and 90 percent by the age of 18. Nelligan stresses that parents need a strategy in raising their children. Tune in to Beyond 50: America's Variety Talk Radio Show on the natural, holistic, green and sustainable lifestyle. Visit www.Beyond50Radio.com and sign up for our Exclusive Updates.

Shamim Momin is the Director of Curatorial Affairs at the Henry Art Gallery in Seattle, Washington. In this role since 2018, she has overseen the Curatorial Department and organized numerous exhibitions, including the museum-wide group exhibition In Plain Sight, as well as major commissions by Tala Madani, Gary Simmons, Kelly Akashi, Donna Huanca, Diana Al-Hadid, and others. Prior to joining the Henry, she was director, curator, and co-founder of LAND (Los Angeles Nomadic Division), a nonprofit public art organization committed to curating site- and situation-specific contemporary art projects. In that role, Momin organized over 100 exhibitions, projects, and programs with more than 300 artists, presented across the United States and internationally. Previously, Momin served for more than ten years at the Whitney Museum of American Art (New York) co-curating the 2004 and 2008 Whitney Biennials and overseeing the Contemporary Projects series. In addition to her extensive publication history, she serves regularly as guest lecturer, panelist, and advisor for a wide array of organizations and events. Momin was Adjunct Professor of Contemporary Art for Williams College for the 2007 and 2008 Semester in New York program, and is currently Affiliate Professor of Art at the School of Art, Art History and Design, University of Washington.She and Zuckerman discuss life transformations, never not thinking about something, founder's fatigue, regret, being useful, learning to listen,   accepting the world, personal responsibility, purpose driven work, humanity, being a mom, mentorship, what the next generation sees, and art as a means to be human!

Live at WSA in New York City on September 24, 2024. Academy Award‒winning filmmaker, drummer, DJ, producer, director, culinary entrepreneur and New York Times bestselling author Ahmir “Questlove” Thompson talks with Williams College pioneering developmental psychologist, Dr. Susan Engel about his debut children's picture book The Idea in You. The book was written to inspire kids to find and follow their own creative voice. We talk about Questlove's childhood, his creative roadblocks, his current relationship to supporting his inner child, Susan's pioneering work researching curiosity in children and what we know about how children come up with ideas. This podcast was produced in collaboration with Water Street Projects, NEW INC and the New Museum.

Chronic pain affects hundreds of millions worldwide, with conditions like gastrointestinal issues, back pain, and migraine topping the list. In many cases, psychological factors play a significant role in causing or worsening pain. Despite overwhelming evidence, the mind-body connection is often ignored or dismissed as "all in your head," as though that makes it less serious. My guest this week has dedicated his work to educating both medical professionals and patients on the power of the mind to relieve and even reverse chronic pain. Listen and learn: How adverse childhood experiences can contribute to or even cause chronic pain Why most medical professionals are not trained in psychological triggers for chronic pain How awareness, vocalization, and writing can potentially help The future of pain treatment Learn more at: EndChronicPain.org ABOUT OUR GUEST Dr. David Clarke is President of the Psycho-physio-logic Disorders Association (PPDA), a nonprofit focused on addressing chronic pain through a biopsychosocial approach. He is board-certified in internal medicine and gastroenterology, with an MD from the University of Connecticut and a bachelor's degree in psychology from Williams College. Dr. Clarke is an international lecturer, author, and advocate for non-invasive treatments of stress-related medical conditions. Like the Show? Leave us a review Check out our YouTube channel

Ep. 214 Kim Dacres is a first-generation American sculptor of Jamaican descent, who lives in Harlem and practices her studio work in the Bronx. She primarily uses rubber from recycled tires to create sculptures celebrating the influential forces in her life such as family, friends, artists and musicians. Dacres was born in the Bronx and has a Bachelor's degree from Williams College in Political Science, Art, and Africana Studies as well as a Masters in Teaching English as a Second Language from Lehman College City University of New York. She spent over a decade in New York City public and charter schools working as a teacher and middle school principal. Now, in her second full time career as an artist, Kim has had solo exhibitions in New York, Los Angeles, and Palm Beach, FL as well group exhibitions internationally and within the U.S., including Surrealism and Us: Caribbean and African Diasporic Artists Since 1940 at the Modern Art Museum of Fort Worth, Texas; Black American Portraits at Spelman College Museum of Fine Art and the Los Angeles County Museum of Art, Sounds of Blackness at The Metropolitan Museum of Manila in the Philippines, Godhead – Idols in Times of Crisis at Lustwarande in the Netherlands, and Bronx Calling Part I at the Bronx Museum as part of the esteemed AIM – Artist in the Marketplace Program. Kim is the recipient of the Artadia New York Award Grant in 2022 and the Bronx Recognizes Its Own (BRIO) Grant in 2023. Her work is in numerous private and public collections including – The Beth DeWoody Collection, the LACMA collection in Los Angeles, The ICA in Miami, the Nasher Museum at Duke University, and the International African American Museum in South Carolina. Portrait: Max Yawney Kim Dacres https://www.kimdacres.com/ Colossal https://www.thisiscolossal.com/2023/07/kim-dacres-tire-busts/ NYTimes https://www.nytimes.com/interactive/2023/06/22/t-magazine/art/kim-dacres-art-exhibit.html Juxtapoz https://www.juxtapoz.com/news/installation/we-insist-upon-ourselves-in-perpetuity-throughout-the-universe-april-bey-and-kim-dacres-in-atlanta/ Hyperallergic https://hyperallergic.com/871489/bronx-museum-sixth-aim-biennial-is-all-about-knowledge-and-agency/ The Hopper Prize https://hopperprize.org/kim-dacres/ Gavlak Gallery https://www.gavlakgallery.com/artists/kim-dacres Welancora Gallery https://www.welancoragallery.com/artists/86-kim-dacres/works/ The Bronx Museum https://bronxmuseum.org/aim-fellow/kim-dacres/ Observer https://observer.com/2023/06/becoming-an-artist-was-a-dream-deferred-for-sculptor-kim-dacres/ Artadia https://artadia.org/artist/kim-dacres/ Office Magazine https://officemagazine.net/skin-hair-muscles-and-bones-kim-dacres Charles Moffett https://charlesmoffett.com/exhibitions/55-kim-dacres-measure-me-in-rotations/ https://charlesmoffett.com/press/65-on-view-bantu-knots-and-braids-sculpted-from/

In this episode Garth interviews Steven Fein from Williams College in Williamstown, MA. Steve discusses his journey into psychology, his passion for teaching, and his ground-breaking research on audience reactions during presidential debates, as well as stereotypes and prejudice. They also discuss social psychology experiments related to unconscious biases, societal implications of political polarization, and modern research on changing conservative views regarding same-sex marriage and gun control. The importance of social science in public health crises, such as COVID-19, is also highlighted, demonstrating how education and social norms can influence prejudice and public opinion. [Note. Descript AI generated portions of the show notes.]

Jennifer Krouse is a real estate strategist and the CEO of Liberty House Plans, an architectural publishing house that provides architectural plans for neighborhood-friendly buildings. Previously, she served as a business advisor to real estate developers and a consultant in the field of municipal productivity. She is a member of the National Town Builders Association and holds a BA from Williams College and an MBA from the Stockholm School of Economics. Krouse returns in this episode of The Bottom-Up Revolution to dive deeper into what it means for an area to be productive. She and host Tiffany Owens Reed also discuss the importance of social capital and smart municipal investment strategies. ADDITIONAL SHOW NOTES Local recommendations: Peter Pan Donuts. Liberty House Plans. Columns Jennifer has written for Strong Towns. Tiffany Owens Reed (Instagram). Do you know someone who would make for a great Bottom-Up Revolution guest? Let us know here!

Good dystopian literature forces its readers to confront ideas of government, culture, community, and identity. This episode of the "Velshi Banned Book Club" will examine two of the most celebrated works of dystopian literature of all time: “The Giver” by Lois Lowry and “1984” by George Orwell. Both novels are staples in the American public education system, the dystopian literary canon, and they are among the most frequently challenged literary works. These books grow along with their readers – from elementary school with “The Giver” onto adulthood with “1984”. Today, perhaps more than ever, these books are necessary -- even critical -- to our collective futures.