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3 episodes with proteolytic
2 episodes with proteolytic
2 episodes with proteolytic
4 episodes with proteolytic
4 episodes with proteolytic
2 episodes with proteolytic
Story at-a-glance A targeted brain rehabilitation program combining digital exercises and coaching helped 80% of long COVID patients return to work, while none in the standard care group did Long COVID cognitive symptoms affect 9 million to 10 million Americans, with nearly one in seven unable to return to work three months after infection Early neurorehabilitation helped unconscious COVID ICU patients regain awareness; over half showed improvement after just eight days off sedation Proteolytic enzymes like lumbrokinase help break down lingering spike protein, reducing inflammation and supporting recovery from neurological symptoms Resources like the Front Line COVID-19 Critical Care Alliance's (FLCCC) I-RECOVER protocol provide comprehensive treatment plans for those experiencing persistent symptoms after COVID infection or injection
Kickstart your Monday with a fresh perspective! Today, we talk all about our free lab selection call and how it can set you on the right path. We're also diving deep into the concept of 'chi'—what it is, how to balance it, and our top TCM guidelines you should definitely consider incorporating into your daily routine. We also explore serrapeptase, and the right dosages to make the most of its powerful benefits. Stay tuned, because this episode is packed with insights you won't want to miss! Tune in to hear: Your subconscious is always listening (2:02) Your life force (7:15) A cauliflower dish you have to try! (8:22) Enzymes explained (9:06) The origin of serrapeptase (12:30) Acute inflammation: next steps (15:00) Head to www.paulabenedi.com/episode259 for the show notes Join our newsletter: www.synergised.info/newsletter Follow Synergised on Instagram: @synergiseduk Follow Paula on Instagram: @paulabenedi . P.S. This podcast and website represent the opinions of Paula Benedi. The content here should not be taken as medical advice and is for informational purposes only, and is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare professional for any medical questions.
In this part 2 episode, we dive into the pathology and symptoms of Babesiosis, exploring how the Babesia parasite infects red blood cells and evades the immune system. We discuss various labs and biomarkers to look out for. We then address various treatment protocols featuring anti-malarials including herbal supplements such as artemisinin and cryptolepis, and proteolytic enzymes like lumbrokinase and nattokinase. Additionally, we cover the use of methylene blue and its impact on Babesia parasites. Topics: 1. Introduction - Brief overview of Babesiosis and previous discussion - Overview of Babesia infection and its impact on red blood cells (RBCs) 2. Pathology of Babesiosis - Infection and multiplication within RBCs - Mechanisms of immune evasion - Expression of specific proteins on RBC surface - Adherence to capillary endothelial cells - Avoidance of spleen clearance - Antigenic variation and immune system evasion 3. Symptoms of Babesiosis - Air hunger - High fever - Severe fatigue - Muscle and joint pain - Persistent headaches - Jaundice - Dark urine - Organ failure (in severe cases) 4. Labs and Markers for Babesiosis - Hematological markers - Hemolytic anemia - Thrombocytopenia - Leukopenia - Hemoglobinuria - Hyperbilirubinemia - Elevated LDH levels - Reticulocytosis - Other markers - High C4a levels - Low CD57 count 5. Protocols - Importance of medical supervision and potential Herxheimer reaction - Overview of treatment approaches 6. Anti-Malarial Protocols for Babesiosis - Prescription Medications - Mepron (Atovaquone), Mechanism of action: inhibition of mitochondrial electron transport chain. - Azithromycin, Mechanism of action: blocking protein synthesis. - Herbal Approaches for Babesiosis - Artemisinin: Derived from sweet wormwood plant. Mechanism of action: production of reactive oxygen species (ROS). - Cryptolepis: Bioactive compound is Cryptolepine, Mechanism of action: disruption of DNA synthesis. 7. Proteolytic Enzymes - Lumbrokinase - Nattokinase 8. Methylene Blue - Synthetic dye - Mechanism of action: disrupting mitochondrial function and generating ROS within Babesia - Administration methods and effects 9. Conclusion - Recap of supplements and treatments discussed - Emphasis on individualized treatment plans, bioindividuality, and working with a medical physician Thank you to our episode sponsor: Liver Medic Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Did you know there is an enzyme that can help you break down abnormal cells and proteins in the body like cysts, scar tissue, and blood clots, as well as detoxifying your blood at a cellular level? On this episode of Vitality Radio, Jared interviews our favorite enzyme educator, Julia Craven, VP of Education for Enzymedica. They do a deep dive on all of the amazing things Nattokinase can do in the body. You'll learn how it works and why it can replace baby aspirin for cardiovascular health and so many other amazing functions in the body. Wondering if it's something you should add to your regimen? Listen and decide if it's best for you!Products:Enzymedica Natto-KEnzymedica Enzyme DefenseSource Natural NattoAdditional Information:#383: The Incredible Benefits of Enzymes For Digestion, Immunity, and Overall Health With Julia Craven#301: Systemic Enzymes for Mucus, Candida, Immune Support, Heart Health and more. Also a Brand New Magnesium! Guest, Julia Craven#292: Food Sensitivities and Digestive Enzymes. How to Ease The Burden with Julia CravenVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Hello! We are discussing proteolytic enzymes today and how they could be beneficial in your health journey, especially for inflamed joints from spider guard, grips in general etc. Also, we touch on UFC fight pass invitational and the issues with it. Hey, if you have any questions for Dr. Chris or Bill and Olivia. Just email GrapplingWithPodcast@gmail.com or message the social media pages. Check us out on our social and YouTube where we have full episodes. Instagram: @GrapplingWithPodcast Facebook: www.facebook.com/GrapplingWithPodcast YouTube: /grapplingwithpodcast Dr. Hardy is a licensed physician and BJJ practitioner, but the contents of the podcast are meant for educational purposes only, and should not be taken as medical advice. Please seek out personalized care from your own medical provider prior to implementing any medical treatment or intervention.
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Anonymous: Hi Doc! Asking for a 36 year old male. He ran the big 5 last year. I'm not sure on the particulars of his results, but I know he has done the detox CBO. Chronic back pain, a reverse curve in his neck shown in chiropractic X-rays. Chronic high blood pressure. Healthy weight, exercises diligently, healthy whole food plant based diet, fairly decent sleep, regular corrective chiropractic care. We recently pieced together that he has systematic vein problems. Temporal Arteritis (self diagnosed), Vericose veins, hemorrhoids, and Varicocele of the scrotum. What would cause this and how can we support his venous/circulatory system? He's been dealing with the varicocele since teen years. Left temple vein pain came a couple of years ago as a result of excessive Wim Hoff breathing. Thanks so much!! Anonymous: Hi dr cabral, I wanted to ask you about your thoughts on raspberry leaf tea to reduce painful period cramps. I have painful periods and I've heard that raspberry leaf tea can help ease the pain. Do you have any studies that you can share regarding this? I'd really like to get your insight on how I can reduce period pain. Thank you. Cara: Hi Dr. Cabral, I'm an IHP2 and I have a friend who has a daughter who has suffered for over 2 years. I have not worked with them yet. However I think this case needs more expertise. She frequently gets lockjaw and it's also osteomyelitis of the jaw, jaw infection, scar tissue from two surgeries, jaw bone deterioration. She's also a bit auto immune. We've seen 4 different naturopaths, 15 different doctors, holistic and regular, mental therapists, all kinds of different western and eastern type of doctors. It's really tough because everyone really doesn't know. They are doing myofunctional + oral posture work currently. She has gone from being vibrant and happy to hurting and shy. Ana: Hi Doc! What are your thoughts on onions and garlic? I'm aware that they're not CBO approved but if someone doesn't have any candida or bacterial overgrowth or any other digestive issues, do you think they should be avoided?According to Ayurveda, onion is tamasic (makes people irritable, agitated and aggressive) in nature and garlic to be rajasic (energy-draining, disturbed sleep and drained energy) in nature. As per Ayurveda, both these ingredients produce excessive heat in the body. However, these vegetables are highly recommended in Naturopathy because raw, crushed garlic has potent therapeutic benefits and red onion for example has loads of antioxidants including quercetin. How often do you consume those foods if you don't mind me asking? Once a week or more regularly? Lindsey: Hello Dr. Cabral, I know you will have an answer to this question. I have asked 3 naturopaths, my midwife and pelvic floor therapist and none have ever done this, but I don't see why it wouldn't work. I had a c-section last October and wanted to use proteolytic enzymes to work on the scar tissue in my body. Any issues you see? Can I do it while breastfeeding? Recommended dose? Also, what would you use to strengthen (or make more elastic) the tissue in my uterus, so that I may have less issues in that area if I want to have another baby via VBAC? Thank you for your insight. Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/2647 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
My guest this week is Dr. David Minkoff with LifeWorks Wellness Center. In this episode, Dr. David Minkoff and I discuss how to optimize health and the unique methods and lens that Dr. Minkoff uses in order to help people with his unique approach to medicine. In this episode we cover everything from peptides to ozone to cooking with tinfoil. We cover quite a few topics that give you little tips on how to make your life healthier. There are lots of options that are virtually free as well as more expensive ideas such as doing maintenance IV ozone treatments multiple times a year. Dr. Minkoff is an alternative healthcare expert, guest lecturer, writer, tv and radio show guest. He also authors two weekly newsletters, the BodyHealth Fitness Newsletter and the Optimum Health Report. Dr. David Minkoff graduated from the University of Wisconsin Medical School in 1974 and was elected to the “Phi Beta Kappa” of medical schools, the prestigious Alpha Omega Alpha Honors Medical Fraternity for very high academic achievement. He is board certified in pediatrics and has completed a fellowship in Infectious Diseases at the University of California in San Diego, which included research in developing new medicines to fight viral disease. As a clinical faculty member at the University, he also served as co-director of the Neonatal Intensive Care Unit at Palomar Medical Center. Learn more about Perfect Aminos and try them for yourself at https://affiliates.bodyhealth.com/1491.htm. Use code NAT20 to get 20% off Follow Dr. David Minkoff https://www.lifeworkswellnesscenter.com/ https://www.facebook.com/lifeworkswellnesscenter/ https://www.instagram.com/lifeworkswellnesscenter/ https://twitter.com/LifeWorksWC ------ Episode Sponsors Nootopia - If you're a biohacker who's looking to push your brain and body to the outer limits of what's possible then check out Nootopia, the most powerful nootropics on the market today. These nootropic stacks are taking the industry by storm because they're safe, legal, and highly effective. Every formula is customized for you based on your strengths, weaknesses, and goals, and formulated by the most advanced brain chemistry nootropics formulator alive today. Taking the right formulas at the right time can help you focus intensely, block out distractions, reduce stress and anxiety, enhance your creativity, boost your memory, and so much more. Within just 15 to 30 minutes, you should begin to feel and notice the mental effects. These formulas come with a full one year guarantee, so there is zero risk to you to try them for yourself. If you want to fully maximize your potential, both personally and professionally, then you owe it to yourself to try Nootopias formulas. They are a total game changer. I use them before every podcast. Just go to https://nootopia.com/ and use Bionat to receive 10% off any order. Oxford HealthSpan brings us Primeadine, the best formulated Spermidine supplement on the market! What makes it stand out – it includes Spermine & Putrescine two other Polyamines that work hand in hand with Spermidine PLUS FOS, a prebiotic to feed the bacteria in your gut that make Spermidine! I take Spermidine daily as do my family and my clients – it has become a solid member of my “foundation stack”. Research has shown that Spermidine upregulates autophagy, helps the immune system to rejuvenate and it protects DNA – visible benefits experienced by myself and my clients include better sleep, hair, skin and nails! Oxford HealthSpan is now offering gluten-free Primeadine! Sponsor offer: If you haven't tried it yet go to Primeadine.com and use promo code BIONAT15 to save 15% of your first order at https://oxfordhealthspan.com/products/best-spermidine-supplement. ------ Episode Takeways [06:15] About Dr. David Minkoff and what led him to functional medicine… [15:00] Blood thinners for post COVID symptoms… [18:00] Proteolytic enzymes, are they helpful?.. [23:50] How to break up biofilm?.. [29:15] Thoughts on EMF's?.. [37:00] How do we keep minerals in the body in balance and heavy metals out of the body?.. [47:00] Glyphosate levels in the body… [49:15] How to keep your body healthy on a maintenance level?.. [60:25] Peptides for lyme, coinfections and general health… ------ Follow Nat Facebook Facebook Group Instagram Mighty Networks BSP Community Work with Nat: Book Your 20 Minute Optimization Consult
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Luis: Hi Dr. Cabral, I was wondering what your thoughts are on DMSO and MMS (Miracle Mineral Supplement), particularly when it comes to taking them for the elimination of things like SIBO, for example, but also for any other purpose? Thanks Melissa: What is the safest water system for an inground pool ? Patrick: Hey doc hope all is well. Huge fan here. I know you did allot of podcasts on proteolytic enzymes but I'm not sure if you mentioned if it would be good to take for acne. I believe you say acne is a result of dirty blood and this enzyme cleans blood so thought this might work good. Thank you for everything you do Lara: Hi, dr. Cabral :) I'm finally on my first FM detox, day 4 & I already feel a bit better, can't wait to see the results after 21 days! And then straight into CBO.. and CBO finisher afterwards.. I wanted to ask when during CBO would be a good time to start with the Heavy Metal Detox, Mold protocol and Ultimate Sleep Help Protocol? Should I wait until the end of CBO or even the Finisher? And when would you recommend my next detox then..? It wouldn't have to be another 21 days, right? After all these protocols my body should be much less toxic? vI would also like to ask if you could do an episode about how to properly brew different teas to get the most benefits.. I'm mostly interested in herbal teas and ginger tea, but I think information about all teas would be beneficial.. Thank you Tonya: Hello Dr Cabral! I have 2 quick questions for you please and thank you! 1. What are the long term effects of donating plasma? 2. Is it okay for people to use exlax every day? (I've seen several moms say their kids with encopresis use ex lax daily and they also say it's safe because it comes from the senna plant.) I also have 2 things you could look into for a review if you'd like, one is the K8 machine (to filter water) ans the other is emf blocking stickers for iPhone and airpods by Waveblock. Take care! Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/2529 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Secrets to upper GI Health: Heartburn and Indigestion When your digestive system doesn't work, you don't work. Did you know most heartburn comes from too little digestion, and taking anti-acids prolongs the problem? Here are five tips on how to improve digestion and get rid of heartburn 1. Eat healthily: Put the healthiest food possible in your stomach. The closer the food is to the earth, the healthier it is. If the food is picked out of your garden, it's way healthier than food that comes from a bag, box, or wrapper. 2. Chew more: Chew your food well and don't eat too fast. 3. Water: Get enough hydration. Your digestive system needs water to function properly. 4. Acid Levels: Do you have too much acid or the wrong kind of acid? Proteolytic enzymes or apple cigar vinegar can help break down the food. If the stomach needs help breaking the food down faster this will help, and it means you have the wrong kind of acid. If enzymes or vinegar make it worse, it's an indication you have too much acid. Too much acid means there is an overstimulation of the vagus nerve. Phosphorus is the magic mineral to help down-regulate this nerve and solve the overproduction of acid. 5. Stomach Protector: Heal and soothe irritated GI tissue with Vitamins A, D, E, & K. Nutritional Recommendations: Fat-soluble vitamins ADE&K help soothe irritated GI tissue, probiotics help when there is a bacterial problem, slippery elm and okra can help clean out the GI system, and magnesium or vitamin c can help with constipation. If you haven't already, hit the subscribe button for more health tips from Dr. J and the West Clinic Team.
Videos: 1. Assange Countdown: In Depth with Dr. George Szamuely (0:20) 2. Frank Zappa – 1979 3. Our freedom is under attack by those who care more for power than for the Constitution, the Bill of Rights & the American people. – Tulsi Gabbard (0:41) 4. Woody Allen speech from movie The Front (0:60) 5. A Christian Response to Wokeness (FULL VIDEO) | Noelle Mering | Leadership Institute (21:51) 6. NBC News just SMEARED real journalists in shameful hit piece | Redacted with Clayton Morris (22:00) 7. Propaganda disguised as education | Let's talk about it – Riks (Start @ 0:58) Nuts Increase Cognitive Scores Among Elderly Women Harvard University and Brigham and Women's Hospital, June 4th 2022 Researchers from Harvard University and Brigham and Women's Hospital have confirmed that eating more nuts every day will increase cognitive skills – at least among elderly women. For six years, the researchers followed 16,010 women who 70 years old or older, and 15,467 completed the final cognitive interviews. The researchers found those women who consumed five servings or more of nuts each week had higher scores on their cognitive testing compared to those who did not consume nuts. The average difference in scores was 0.08 units, which is equivalent to two years of cognition decline during the aging process. The mechanism may be related to the fact that nuts are heart-healthy. And nut consumption has been associated with cardiovascular healthand mortality in other research. Stress accelerates immune aging, study finds University of Southern California, June 13, 2022 Stress—in the form of traumatic events, job strain, everyday stressors and discrimination—accelerates aging of the immune system, potentially increasing a person's risk of cancer, cardiovascular disease and illness from infections such as COVID-19, according to a new USC study. The research, published in the Proceedings of the National Academy of Sciences (PNAS), could help explain disparities in age-related health, including the unequal toll of the pandemic, and identify possible points for intervention. USC researchers decided to see if they could tease out a connection between lifetime exposure to stress—a known contributor to poor health—and declining vigor in the immune system. As expected, people with higher stress scores had older-seeming immune profiles, with lower percentages of fresh disease fighters and higher percentages of worn-out white blood cells. The association between stressful life events and fewer ready to respond, or naive, T cells remained strong even after controlling for education, smoking, drinking, BMI and race or ethnicity. CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial Shahid Sadoughi University of Medical Sciences (Iran), June 8 2022. A double-blind trial reported in a recent issue of the International Journal of Vitamin and Nutrition Research found a reduction in markers of inflammation in mildly hypertensive patients given coenzyme Q10 (CoQ10) for twelve weeks. Participants who received CoQ10 also experienced an increase in adiponectin: a protein secreted by adipose tissue that has an anti-inflammatory effect and which has been found to be reduced in high blood pressure and cardiovascular disease. “Considering that coenzyme Q10 has attracted noticeable attention in recent years for the treatment of cardiovascular diseases and hypertension in regard to its effect on inflammatory factors such as cytokines, it is therefore hypothesized that supplementation with coenzyme Q10 reduces the proinflammatory factors,” write Nasim Bagheri Nesami of Iran's Shahid Sadoughi University of Medical Sciences and colleagues. “This study was conducted in order to determine the effects of coenzyme Q10 on proinflammatory factors as well as on adiponectin in patients with mild hypertension.” Sixty men and women were randomized to receive 100 milligrams CoQ10 or a placebo for a twelve week period. Plasma adiponectin, high-sensitivity C-reactive protein (hs-CRP, a marker of inflammation) and the cytokines interleukin 2, interleukin6 and tumor necrosis factor-alpha were measured before and after treatment. At the end of the study, participants who received CoQ10 had significant declines in interleukin-6 and hs-CRP compared with levels measured upon enrollment. They also experienced an increase in adiponectin, while levels in the placebo group slightly declined. Probiotics prevent deadly complications of liver disease Govind Ballabh Pant Hospital, New Delhi, India June 6, 2022 Probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver, according to a new study in Clinical Gastroenterology and Hepatology. Hepatic encephalopathy is a deterioration of brain function that is a serious complication of liver disease. “This rigorous new research finds that probiotics modify the gut microbiota to prevent hepatic encephalopathy in patients with cirrhosis of the liver,” said David W. Victor III, MD. “These results offer a safe, well-tolerated and perhaps cheaper alternative to current treatments.” When comparing treatment with probiotics versus placebo, the researchers found that the incidence of hepatic encephalopathy was lower in patients treated with probiotics. Probiotic supplementation was not associated with any side effects and none of the patients required discontinuation of therapy. These results suggest that probiotics are similar in effectiveness to the current standard of care, lactulose, in the prevention of hepatic encephalopathy, yet they appear to be much better tolerated. The effectiveness of lactulose, a nonabsorbable disaccharide, is limited by side effects (diarrhea, bloating and gas) and a narrow therapeutic window. Chelation therapy and vitamin supplements cut heart disease risk by over 25% Columbia University, June 9, 2022 A combination of high-dose multivitamins and chelation therapy may protect heart attack survivors from future cardiovascular events and death, according to a multicenter study published in the American Heart Journal. Intravenous chelation, in which the chemical ethylenediaminetetraacetic acid (EDTA) is injected into the bloodstream in order to bind to minerals and help flush them from the body, is an FDA-approved treatment for heavy metal poisoning that was first used during World War I. “They're all in our environment. Any of us who are of an age to have been exposed to leaded gasoline have lead in our bones. If we get an infusion of EDTA, we'll have lead in our urine. It's just the way it is. And as you get older and become osteoporotic, that lead starts getting released.” In a randomized, double-blind trial, the researchers randomly assigned 1,708 stable heart attack survivors at 134 clinics across the United States to one of four experimental conditions: high-dose oral multivitamins plus chelation, chelation plus a vitamin-mimicking placebo, vitamins plus a chelation-mimicking placebo or double placebo. Participants had to get a 500 cc intravenous infusion once per week for 30 weeks, followed by another 10 infusions spaced two to eight weeks apart. All participants also had to take six large capsules daily. The researchers found that chelation alone led to a statistically significant 18 percent reduction in primary endpoint, relative to placebo. Chelation plus multivitamins led to a 26 percent reduction in risk over placebo. Chelation plus multivitamin also reduced the secondary endpoint by 34 percent, compared with placebo. Diabetic participants benefited even more dramatically. Among diabetics, chelation resulted in a 41 percent reduction in primary endpoint, while chelation plus vitamins resulted in a 51 percent reduction. The rate of all-cause mortality in diabetic patients dropped 43 percent with chelation alone, and the secondary endpoint was also reduced. Natural Pain Killer With Powerful Ability to Remove Blood Clots and Dead Tissue GreenMed Info, June 13th 2022 Serrapeptase, also known as serratiopeptidase or serralysin, is a systemic enzyme, specifically it is a proteolytic enzyme. Serrapeptase was first derived from a species of bacteria found in the intestine of the silkworm. The bacteria, Serratia mercesans E1, produces serrapeptase to help breakdown the silkworm coccoon to free the silk moth. A review study summarized that serrapeptase has immense applications in therapeutic areas which have been validated by several in vitro, in vivo, and clinical studies. “These applications are attributable to its versatile properties including anti-inflammatory, anti-biofilm, analgesic, anti-edemic, and fibrinolytic effects.” Serrapeptase has been used for a wide range of health concerns: Serrapeptase for Joint Swelling Serrapeptase is effective in reducing post-operative joint swelling in comparison to other therapies such as applying ice. Serrapeptase Dissolves Blood Clots, Dead Tissue, Biofilms Anticoagulants and antiplatelet drugs are used for managing cardiovascular diseases but they are unable to dissolve an existing blood clot. Serrapeptase dissolves a fibrin clot within a blood vessel. Studies have shown that serrapeptase can digest dead tissues, blood clots, cysts, biofilm and arterial plaques. Serrapeptase for Acute or Chronic Ear, Nose and Throat Conditions The Journal of International Medical Research published the results of a study evaluating the efficacy and tolerability of serrapeptase using a double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. Patients treated with serrapeptase reported significant symptom regression within 3 – 4 days. It was concluded that serrapeptase “has anti-inflammatory, anti-oedemic and fibrinolytic activity and acts rapidly on localized inflammation.” COVID-19 and Chronic Respiratory Conditions A 2021 study, showed, “Proteolytic enzymes can be useful in the treatment of nosocomial, viral, and resistant infections, especially in pediatric and geriatric age groups due to its relative safety, less tolerance and resistance and its synergic effects.” Physicians have observed many COVID-19 cases with heart problems, kidney problems, and the presence of blood clots. Serrapeptase helps patients with chronic airway disease by reducing coughing and lessening viscosity of sputum. As a natural anticoagulant it interferes with platelet aggregation and the blood coagulation cascade. Serrapeptase has an anti-inflammatory impact on the tissue inflammation that contributes to the blood clot formation.
Clive De Carle returns to InnerVerse to share his nutritional knowledge about the myriad of methods to help our meat-suits mend from any and all maladies, using the building blocks of nature found in natural, food-based medicines. We discuss growing your own "garden-variety" supplements, repairing damage with protoeolytic enzymes, "Factor X" and Vitamin K2, healing our teeth, medical mercury, and water strategies.Video of this episode: https://youtu.be/Qow5-fnhOHIGet InnerVerse Plus+Rokfin: https://rokfin.com/stream/17985Patreon: https://www.patreon.com/posts/66059625In the Plus+ Extension we talk about Clive's experience with mitigating diabetes, the connection between selenium, nutrition and willpower, the innate intelligence of the body, MSM Sulpher, fixing damaged lungs, varieties of Vitamin C, neutralizing toxic tap water with Vitamin C and Borax, wearable laser-therapy devices, and much more!EPISODE LINKSGet Clive's Supplements & Support InnerVerse with this link: https://clivedecarle.ositracker.com/197164/11489Music in this episode: "The Cudgel" by LC King - https://rokfin.com/lcKinghttps://www.innerversepodcast.com/season-8/clive-de-carle-proteolytic-enzymesTELEGRAM LINKSInnerVerse Channel - https://t.me/innerversepodcastInnerVerse Group Chat - https://t.me/innerversepodcastchatWORK WITH MESound Healing Therapy: https://www.innerversepodcast.com/sound-healingOracle Card Counseling: https://www.innerversepodcast.com/oracle-cardsSUPPORT INNERVERSESpirit Whirled: July's End (Audiobook narrated by Chance) - https://tinyurl.com/2dhsarasInnerVerse T-Shirts, Posters & Art Store - https://www.designbyhumans.com/shop/TripFlipArt/t-shirts/Add to your metaphysical toolkit at Secret Energy - https://store.secretenergy.com/?ref=chancegartonThe Aquacure AC50 (Use "innerverse" as a coupon code for a 15% discount) - https://eagle-research.com/product/ac50 See acast.com/privacy for privacy and opt-out information.
#Adrian #health #CliveDeCarle If you want to buy Clive's Natural Health Essentials and join The Secret Health Club which gives you access to very rich detailed (and censored) content please use this affiliate link: https://clivedecarle.ositracker.com/239640/11489My book:I have written a book on health and well-being. Nothing mainstream in here, just things I've observed and worked out that have helped me and others who have used the ideas.You can read more about it here:http://alternativeprinciplesforhealth.info/—Drinking distilled water is one of the best things you can do for your health. To buy a distiller via our affiliate link:https://www.makewaterpure.co.uk/?cmid=THVmWlZFWFJYRVk9&afid=YVJqdUJQMWI2Tms9&ats=YXErRWFBS3hCd1E9To listen to the entire episode:YouTube: https://youtu.be/FVzeWkBFYEYBitchute: https://www.bitchute.com/video/TTojzWfxAusp/Brighteon: https://www.brighteon.com/1976a000-c828-4b2e-a5a8-663a167d12cfOddysey: https://odysee.com/@adrianr:8/ep.-249-clive-de-carle-nutritional:7Podcast: https://fortheloveoftruth.co.uk/podcast/ or https://fortheloveoftruth.buzzsprout.com/Make sure to sign up for my newsletter so you never miss any new content and offers: https://fortheloveoftruth.co.uk/newsletter-signup/—Support the show
The Pipeman interviews Sara Banta. Everyone in Sara's town got covid. During Christmas Sara got covid with minor symptoms. Pipeman had chicken pox as an adult. The vaccine for chicken pox you must get a booster every seven years. Immune system remembers illnesses. The best thing you can do is boost your immune system. Accelerated silver for your immune system. It's a physical product with he smallest silver particle product possible. People who are sick, taking a dose 3 to 5 times a day. You can put it in your eyes, mouth, nose, safe for all applications. Accelerated iodine. Iodine deficiency is a main cause of depression. Increases atp in the cells. Atp increases everything increases. 3 drops 3 times a day. Work up to 25 drops 3 times a day. Most pills have a 10% absorption rate. When you take something so pure, liquid form is best. The number of heavy metals our bodies take increased since last year. 5G is messing up their flight patterns so they want to hold up on that in aircrafts. When preventing flu make sure you're doing your electrolytes. Sea water is great for all minerals. Hydration of the cells. Getting the proper ratios. To much water could dehydrate you. Accelerated keto, triggers detoxification. Helps you intermittent fast. Cleanses the liver. Supports a stronger immune system. Stem cells activation patches. The 2 are glutathione patch and x 39 stem cell patch. Over 300%. Proteolytic enzymes help with inflammation. Stress and fear will lower your immune system. You can find Sara and acceleratedhealthproducts.com.Take some zany and serious journeys with The Pipeman aka Dean K. Piper, CST on The Adventures of Pipeman also known as Pipeman Radio syndicated globally “Where Who Knows And Anything Goes”. Listen to & Watch a show dedicated to motivation, business, empowerment, inspiration, music, comedy, celebrities, shock jock radio, various topics, and entertainment. The Adventures of Pipeman is hosted by Dean K. Piper, CST aka “The Pipeman” who has been said to be hybrid of Tony Robbins, Batman, and Howard Stern. The Adventures of Pipeman has received many awards, media features, and has been ranked for multiple categories as one of the Top 6 Live Radio Shows & Podcasts in the world. Pipeman Radio also consists of multiple podcasts showing the many sides of Pipeman. These include The Adventures of Pipeman, Pipeman in the Pit, and Positively Pipeman and more. You can find all of the Pipeman Podcasts anywhere you listen to podcasts. With thousands of episodes that focus on Intertainment which combines information and entertainment there is something for everyone including over 5000 interviews with celebrities, music artists/bands, authors, speakers, coaches, entrepreneurs, and all kinds of professionals.Then there is The Pipeman Radio Tour where Pipeman travels the country and world doing press coverage for Major Business Events, Conferences, Conventions, Music Festivals, Concerts, Award Shows, and Red Carpets. One of the top publicists in music has named Pipeman the “King of All Festivals.” So join the Pipeman as he The Pipeman Radio Tour to Life right before your ears and eyes.All Pipeman Radio Podcasts are heard on Talk 4 Podcasting, iHeartRadio, Pandora, Amazon Music, Audible, Spotify, Apple Podcast, Google Podcasts and over 100 other podcast outlets where you listen to Podcasts. The following are the different podcasts to check out and subscribe to:•The Adventures of Pipeman•Pipeman Radio•Pipeman in the Pit•Positively PipemanFollow @pipemanradio on all social media outletsVisit Pipeman Radio on the Web at theadventuresofpipeman.com, pipemanradio.com, w4cy.com, talk4tv.com, talk4podcasting.comPhone/Text Contact – 561-506-4031Email Contact – dean@talk4media.com The Adventures of Pipeman is broadcast live daily at 8AM ET.The Adventures of Pipeman TV Show is viewed on Talk 4 TV (www.talk4tv.com).The Adventures of Pipeman Radio Show is broadcast on W4CY Radio (www.w4cy.com) and K4HD Radio (www.k4hd.com) – Hollywood Talk Radio part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com). The Adventures of Pipeman Podcast is also available on Talk 4 Podcasting (www.talk4podcasting.com), iHeartRadio, Amazon Music, Pandora, Spotify, Audible, and over 100 other podcast outlets.
The Pipeman interviews Sara Banta. Everyone in Sara's town got covid. During Christmas Sara got covid with minor symptoms. Pipeman had chicken pox as an adult. The vaccine for chicken pox you must get a booster every seven years. Immune system remembers illnesses. The best thing you can do is boost your immune system. Accelerated silver for your immune system. It's a physical product with he smallest silver particle product possible. People who are sick, taking a dose 3 to 5 times a day. You can put it in your eyes, mouth, nose, safe for all applications. Accelerated iodine. Iodine deficiency is a main cause of depression. Increases atp in the cells. Atp increases everything increases. 3 drops 3 times a day. Work up to 25 drops 3 times a day. Most pills have a 10% absorption rate. When you take something so pure, liquid form is best. The number of heavy metals our bodies take increased since last year. 5G is messing up their flight patterns so they want to hold up on that in aircrafts. When preventing flu make sure you're doing your electrolytes. Sea water is great for all minerals. Hydration of the cells. Getting the proper ratios. To much water could dehydrate you. Accelerated keto, triggers detoxification. Helps you intermittent fast. Cleanses the liver. Supports a stronger immune system. Stem cells activation patches. The 2 are glutathione patch and x 39 stem cell patch. Over 300%. Proteolytic enzymes help with inflammation. Stress and fear will lower your immune system. You can find Sara and acceleratedhealthproducts.com.The Power of Pipeman is a Motivational, Business, Marketing, Empowerment & Inspirational segment of The Adventures of Pipeman Radio Show (#pipemanradio). The live show is broadcast live on W4CY Radio (www.w4cy.com), W4VET Radio, and K4HD Radio - Hollywood Talk Radio (www.k4hd.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com). This podcast is also available on Talk 4 Podcasting (www.talk4podcasting.com).
The Pipeman interviews Sara Banta. Everyone in Sara's town got covid. During Christmas Sara got covid with minor symptoms. Pipeman had chicken pox as an adult. The vaccine for chicken pox you must get a booster every seven years. Immune system remembers illnesses. The best thing you can do is boost your immune system. Accelerated silver for your immune system. It's a physical product with he smallest silver particle product possible. People who are sick, taking a dose 3 to 5 times a day. You can put it in your eyes, mouth, nose, safe for all applications. Accelerated iodine. Iodine deficiency is a main cause of depression. Increases atp in the cells. Atp increases everything increases. 3 drops 3 times a day. Work up to 25 drops 3 times a day. Most pills have a 10% absorption rate. When you take something so pure, liquid form is best. The number of heavy metals our bodies take increased since last year. 5G is messing up their flight patterns so they want to hold up on that in aircrafts. When preventing flu make sure you're doing your electrolytes. Sea water is great for all minerals. Hydration of the cells. Getting the proper ratios. To much water could dehydrate you. Accelerated keto, triggers detoxification. Helps you intermittent fast. Cleanses the liver. Supports a stronger immune system. Stem cells activation patches. The 2 are glutathione patch and x 39 stem cell patch. Over 300%. Proteolytic enzymes help with inflammation. Stress and fear will lower your immune system. You can find Sara and acceleratedhealthproducts.com.Positively Pipeman is a Motivational, Business, Marketing, Empowerment & Inspirational segment of The Adventures of Pipeman Radio Show (#pipemanradio). The live show is broadcast live on W4CY Radio (www.w4cy.com), W4VET Radio, and K4HD Radio - Hollywood Talk Radio (www.k4hd.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com). This podcast is also available on Talk 4 Podcasting (www.talk4podcasting.com).Positively Pipeman features international authors, speakers, trainers, & coaches here to help you in business & personal life with motivation, empowerment, inspiration, self-help, relationships, goal setting, belief, mindset, marketing, sales, and a journey to success, freedom, and happiness!
Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world's premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He's been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME – noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We're fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. Resources: Learn More about Organixx Enzymes 17 Shop Organixx Enzymes 17 Proteolytic Enzymes What Is the pH of the Stomach? National Center for Health Statistics Digestive Diseases Statistics for the United States Collagens: Hype or Healthy – Episode 15 Proteolytic Enzymes: What They Are & Why Your Body Needs Them to Live Why You Need Enzymes for Good Digestion & Health (+ 8 Signs You May Have an Enzyme Deficiency) Enzymes: Often Overlooked, but Critically Important
Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world's premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He's been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME – noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We're fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. Resources: Learn More about Organixx Enzymes 17 Shop Organixx Enzymes 17 Proteolytic Enzymes What Is the pH of the Stomach? National Center for Health Statistics Digestive Diseases Statistics for the United States Collagens: Hype or Healthy – Episode 15 Proteolytic Enzymes: What They Are & Why Your Body Needs Them to Live Why You Need Enzymes for Good Digestion & Health (+ 8 Signs You May Have an Enzyme Deficiency) Enzymes: Often Overlooked, but Critically Important
So, you've had an endometriosis surgery and you're really hopeful that's this is it – you're going to have some relief, for a while at the least. Maybe your periods are better, your chronic pelvis pain is better, things are improving. But after a few months, the endo belly comes back. Or maybe you get it for the first time ever. You're bloated all the time or maybe you bloat badly after meals, or maybe it gets worse over the day? Perhaps it's also accompanied by IBS issues like constipation, gas, or loose stools. If any of this sounds familiar, this episode is for you. Whilst surgery is essential for many people, it doesn't come without its risks. And I honestly feel like it's a disservice that these aren't more talked about. So today, I'm talking about why you may get endo belly for the first time, a return of it or a worsening of it as a result of adhesions, and what you can do to prevent them. If you haven't heard me bang on about these guys before, adhesions are a form of scar tissue. They are web-like structures and bands of collagen that grow in response to injury and trauma, to ‘knit' back together a wounded area and as part of the healing process from infection and inflammation. Collagen strands bond together to protect the damaged area to allow healing to occur in a safe and isolated environment, and if an infection is present, they protect the rest of the body by preventing the spread. Adhesions occur in nearly all cases of abdominal surgery, the results vary from study to study, but one large and long study found that between 55% to 100% of women who had pelvic surgery developed adhesions, and up to 90% of people who had major abdominal surgery - so something like a caesarean - developed adhesions. So, if you've had even one or more surgeries for endo, it's very likely that you have some adhesions. Now adhesions are a leading cause of the condition, small intestine bacterial overgrowth. This is another topic I bang on about all the time, but if you're new here, I am specialised in endometriosis and SIBO, because SIBO is so prevalent in our community, the research at present is indicating that 80% of us have it. And SIBO is a condition where the normal bacteria which should be in our large intestine (this is referred to as our gut microbiome), starts accumulating in our small intestine, where it shouldn't be. Normally, bacteria are moved through the small intestine into the large intestine with the help of something called the migrating motor complex, and this MMC is a wave like motion that sweeps the small intestine of any left-over food bits and bacteria, and it kicks in about two hours after meals and at night whilst we're asleep. Now a number of things can damage the MMC or prevent it from doing its job. Food poisoning or gastroenteritis is the main cause of damage to the MMC, and that actually damages nerves and muscles that control it. But adhesions, even if the MMC is working well, they can stop it from doing its job properly. And they do this by pulling on our intestines. So, imagine you have an adhesion that is going from your pelvis to somewhere on your intestines, it's going to be pulling down on your intestines and distorting the shape or the flow of the intestines. In fact, your intestines need to be able to slip and slide over each other, they need to be able to expand and accommodate food and waste, but if they're being yanked in different directions and they're being held in place by adhesions, the flow is going to disrupted. There may even be adhesions wrapped around the intestine, which would create an obstruction, or the adhesions may have caused the intestine to loop over itself, creating a pocket area that the bacteria can't escape from. Whatever is happening, the result is the same. The small intestine can't get clean, and bacteria builds up, causing SIBO. And the small intestine isn't designed to house bacteria, so this causes all sorts of problems like bloating, which is a main cause of the endo belly and IBS issues. The gases that are released from the bacteria can also cause brain fog, fatigue, joint pain, and body pain to name a few symptoms. I've linked to a couple of episodes where I break down SIBO in more detail, so if you're not familiar with it, have a listen to that. Now even if SIBO hasn't developed yet, adhesions may still be a source of your bloating. If they're not affecting your small intestine, they could still be affecting your large intestine and may be causing a build-up of waste or gas, you may not be able to have regular bowel movements or your intestines might be sluggish and slow, allowing for gases to accumulate, creating that swelling. So, what's the solution? Prevent the adhesions from taking root in the first place, or if they have, start to break them down. So first up, just as a caveat, we want to be lowering inflammation levels before and after surgery with good anti-inflammatory nutrition. Now inflammation occurs during healing, it's actually part of the healing process, but too much of it for too long will encourage adhesion formation. We want a healthy level of inflammation that aids in healing, not a chronic level that accelerates the growth of adhesions. So, before your surgery and during your healing phase, make sure you're filling your diet with those anti-inflammatory foods I always harp on about: colourful vegetables and fruits; healthy fats like avocado, olive oil, nuts, seeds, and fatty fish; antioxidant packed herbs and spices; and organic lean protein sources beans and lentils, free range organic omega 3 rich eggs, wild caught fish and free range, organic, grass-fed meat. If you want to learn more, I've linked to a few of my podcast episodes on anti-inflammatory nutrition and a free copy of my cookbook in the show notes. I should also be bringing out a nutrition for endo workshop in the next few weeks too, so keep your eyes peeled for that. Okay, so now that's cleared up, let's dive into the extra strategies. I'm going to start with what you can do before and initially after the surgery, and then what you can do once the scars have healed. 1. Number one is supplementing with omega 3 fatty acids. Fish oil was shown to reduce adhesion formation following surgery on mice with induced endometriosis, and reduced the inflammatory healing process post-surgery, which could reduce the chances of further endo development as inflammatory chemicals like prostaglandins fuel endometriosis. This led to the mice who were fed with fish oil to have fewer lesions than those who were fed a standard diet without fish oil supplementation, so even though we don't have research specifically on adhesion formation and omega 3 on humans with endo, this could be a potential helpful supplement before and after surgery (though I would argue it's an essential daily supplement). The therapeutic dose is between 1000mg to 3000mg a day. I personally find I get more pain relief from the higher doses, but it can be tricky to get hold of those levels without exceeding the dose recommendations on the bottle. I have linked to a few higher dose supplements in the show notes, but if you chose to exceed the dose recommendations on the label, obviously that's your choice but you'll need to consult with a practitioner to be on the safe side. However, omega 3 fatty acids are generally very safe at these doses. If you're vegan, look for an algae-based supplement that contains both DHA and EPA, because we need both. I've linked to a few in the handout. The only risk is that they can sometimes thin blood, so speak to your surgeon ahead of surgery to see whether you need to stop taking them a few days beforehand, for keyhole surgery it's unlikely, but just check. 2. Number 2 is proteolytic enzymes. Proteolytic enzymes are natural substances that break down protein, and of course, the building blocks of muscle and tissue are amino acids, which form protein. As a result, proteolytic enzymes help to reduce adhesion formation and they also reduce inflammation post-surgery and aid in clearing waste products from the wound site. The research is limited, with most of the research being in oral surgery or sports related injuries but there is one study on endometriosis. So, the only study we have on enzymes for endo is the use of a brand we use commonly at IWHI and that's Wobenzyme. In the study, Wobenzyme was shown to reduce pain and inflammation post-surgery, reducing the chances of adhesions growth and it also inhibited the formation of new blood vessels, reducing the chances of further endo development. The dose used in the study was the label dose for 40-60 days pre-op and then 60 days post op. One thing to note is that because proteolytic enzymes reduce adhesion formation, there is the risk that if there is an infection at the site of the wound, that it could spread, as adhesions play a role in isolating infection sites from the rest of the body. This is rare but has been known to happen. 3. Number three is home Arvigo Massage. Now, everyone is different, but my recommendation is as soon as your scars have healed and the therapist gives you the go ahead, learn Arvigo massage from a licensed therapists and start practising on yourself every day or a couple times a week. This really increases blood flow and helps to clear away scar tissue. It only takes 10 minutes and can be part of your evening routine, because if you do it at night, it actually helps to stimulate your MMC, so that will also help to reduce your chances of clearing SIBO. So that's a great tool you can be trying at home and that's like your daily maintenance. But we do want to go in with the bigger guns and that's so that's number four. 4. Number four is having some form of professional abdominal massage known as manual therapy, which is designed to break up adhesions. Manual therapy is a form of organ massage and manipulation to break down and prevent adhesions from forming, unstick organs and release a frozen pelvis. Your main options are visceral manipulation or Clear Passage. Visceral manipulation is a form of manual therapy which was designed by Jean-Pierre Barral. It's generally the more affordable and accessible option and is very effective for treating adhesions. Not much research has been specifically done on its effects on endometriosis, but there is plenty of research on its effects for pain conditions and lots of clinical research with endo patients experiencing success from treatment. The holy grail of manual therapy is Clear Passage. This is a unique form of manual therapy which is designed for adhesions and is incredibly effective for SIBO and endometriosis. In fact, there is even amazing research behind it for these conditions, showing its effectiveness. If you're contemplating a surgery but you're not sure it's necessary or the right path for you, for whatever reason, and you have the money to afford Clear Passage, you may want to look into it first because it can even prevent the need for surgery with endometriosis. Of course, if you have cysts that need removing or deep infiltrating endo that's damaging your organs, I am not saying to ignore the advice of a surgeon and not have surgery, but in some cases, surgery isn't the best option – especially if you've already had a few. Research has shown that the pain relief from Clear Passage is the same as surgery and is long lasting, and they all have remarkable results for endometriosis related infertility, pain during sex, and menstrual or ovulatory pain. They also have wonderful results for SIBO and are endorsed by many of the world's leading SIBO doctors. Honestly, I wish all of my clients with SIBO, and endo could have Clear Passage because the results from the studies are so positive. However, it's very expensive so if you can't afford it, honestly, don't worry and try the Arvigo massage and visceral manipulation approach. 5. Lastly, you could also try regular castor oil packs. I know countless leading women's health practitioners who use castor oil to soften and break down adhesions and who experience great success with it with their clients. However, it's generally considered that more research needs to be done, though there is research on castor oil's abilities to lower inflammation, reduce symptoms of constipation, improve circulation, and stimulate muscle relaxation. I actually asked Arvigo Therapist Tara Ghosh about using castor oil packs for breaking down adhesions and she explained how it works. So, castor oil actually triggers the immune system, due to some of its chemical components, but once it responds to the call and finds no poison to clear, the immune system goes about utilising its tools on repairing and healing the pelvic area seeing as it's already there, which in turn helps to break down and clear adhesions. She also emphasises that it lowers of inflammation and improves of blood flow to the area, and that this also helps to clear adhesions or prevent their formation. If you want to learn how to make your own castor oil pack and how and when to safely use them, I advise listening to my interview with Tara who has a really quick and easy method as opposed to the often messy and sticky traditional approach! You can try a castor oil pack alongside your Arvigo massage a couple of times a week once your scars have healed. And if you're years past surgery, don't worry – other than the proteolytic enzymes, you can use all of these strategies to break down any old adhesions that have formed! With the proteolytic enzymes, we only have research that focuses on pre- and post-surgery, so I really couldn't say whether they would work years after surgery, you could try, but I just can't make any guarantees! So that's it! I hope that this episode provides you with a bit of a protocol for healing post-surgery and preventing adhesion formation. I think it's actually appalling that we're not told about them and how to manage them, given that they cause people with endometriosis so many problems, but hopefully this gives you some tools to get to work with. Listen and subscribe on your favourite player or listen directly/download MP3 here or just listen below! Let's get social! Come say hello on Instagram or sign up to my newsletter. Sign up to my free Endo Belly Challenge here. To become a The Endo Belly Course Founding Member, email me at hello@thisendolife.com with ‘Yes' in the subject line. Sign up to the wait list for my course, Live and Thrive with Endo here. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. This episode is sponsored by The Pod Farm. Learn all about how to start your own podcast with the complete course from The Pod Farm. Aimed at beginners, this course takes a simple and straightforward approach to planning, equipment buying, setting up, recording, editing and hosting your own podcast. With hours of audio and video materials, and downloadable guides and useful links, this multimedia approach aims to have something for every kind of learner. From now until April 15, newsletter subscribers get 20% off the course price. Visit www.thepodfarm.com to enroll or find out more This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk
As some of you may know, I’m doing a lot of work at present to free up my pelvic area from adhesions and tightness caused by pulled fascia and a tight pelvic floor, which in physio speak is a hypertonic pelvic floor. So I thought this would be a great time to talk about some strategies you can bring into your daily life to help loosen adhesions and a frozen pelvis. Transcript: I’ve talked about adhesions and fascia before, but let’s do a quick recap of what adhesions and fascia are. So fascia is a thin sheet of tissue made from collagen that sits beneath your skin and holds your organs and muscles in place. It also surrounds all the organs, nerves, blood vessels, etc. Fascia surrounding the body is like a bed sheet, if you pinch it or one end, the rest will wrinkle. So what can happen when we’ve had surgery is that these incisions create puckering and scarring in the fascia, which ends up tightening the fascia and pulling it in other directions. Fascia can also become distorted from inflammation, injuries and muscular problems like pelvic floor dysfunction. Adhesions are a form of scar tissue. They are web-like structures and bands of collagen that grow in response to injury and trauma, to ‘knit’ back together a wounded area and as part of the healing process from infection and inflammation. Collagen strands bond together to protect the damaged area to allow healing to occur in a safe and isolated environment, and if an infection is present, they protect the rest of the body by preventing the spread. Adhesions occur in nearly all cases of abdominal surgery, the results vary from study to study but one large and long study found that between 55% to 100% of women who had pelvic surgery developed adhesions, and up to 90% of people who had major abdominal surgery - so something like a caesarean - developed adhesions. So, if you’ve had one or more surgeries for endo, it’s very likely that you have some adhesions. Adhesions can also form from inflammation, which we know occurs in those of us with endo due to the lesions and can occur in those of us with SIBO, because the body sees it as an infection. Again, as you probably know by now, research has shown that up to 80% of us with endo may have SIBO, so this could be an additional cause of your adhesions and frozen pelvis. It’s also worth noting here that adhesions can actually cause SIBO too, because they prevent the normal flow of gut. So, what can we do about it? Thankfully, there are numerous ways to loosen adhesions and free up a frozen pelvis, and as a result, lower the pain and other challenges associated with them. So let’s dive in to my top 8 strategies. This list isn’t exhaustive by any means, and you don’t need to do them all! Just pick those that feel the most helpful for you and suit your lifestyle and budget. 1. Foam Rolling Number one is foam rolling, which is an effective and affordable at home strategy which you can use every day if you’d like to! With foam rolling, we’re really looking at loosening the fascia rather than working on the adhesions directly. As I said earlier, fascia can get tight, pulled, puckered, and wrinkled, and if it’s experiencing it in one place, it can affect other areas in the body. Foam rolling helps to release a distorted fascia and is when we literally use a long foam cylinder to roll back and forth across various areas of our body. With foam rolling for endo or other pelvic pain issues, we’re not just rolling back and forth on our pelvis, we’re rolling across our hips, bums, back, upper back and legs. In the show notes I have linked to videos on how to do this, by physiotherapist Dr. Nicole Cozean. You can order foam rollers from Amazon for about £11 and in the beginning, I would suggest starting gently with a soft roller that’s smooth, especially if you’ve experiencing a lot of pain. Now with all of these methods, listen to your body. Some discomfort is normal when we’re working with releasing facia and adhesions, but if it’s really painful, ease up and go lightly or if it doesn’t feel right at all, appreciate that this may not be the right approach for you at first. In an ideal world, we’d use these strategies under the guidance of a physiotherapist, but I know that’s not always an affordable option for everyone, so carefully watch the tutorials and if you’d like to do some further research to be really comfortable, I suggest reading Know Your Endo by Jessica Murnane, as she interviews Heba Shaheed, who I’ve had on the podcast before as well, and they talk about foam rolling extensively in the book. 2. Visceral Manipulation Next up is visceral manipulation, which honestly, if you can afford it, I really believe is worth a try! Visceral manipulation is a form of organ massage which was designed by physiotherapist Jean-Pierre Barral with the particular intention to free up organs from adhesions and other structural issues that are restricting them. Organs are supposed to be able to expand and move gently as our body moves, and glide smoothly over muscles and nerves as we go about our day. When adhesions or some kind of other structural problem is keeping them stuck, that’s when we can experience pain and organ dysfunction. Visceral manipulation is very effective for releasing these organs and loosening adhesions and I’ve seen some incredible results with my clients. What I will caution here is that it can feel quite intense and aggressive at times, and if your pelvis is very stuck, you may be better off starting more gently with a different type of massage like some kind of womb massage such as the one I’m going to suggest in the next point. If you’re going to try visceral manipulation, make sure you’re comfortable with your therapist and be very clear with them about the pain or discomfort you experience within the session, so they know when to ease up or when to stop working on an area if it feels too much. I can tell you from personal experience that gritting your teeth and baring it does not always end well! Other greats forms of organ/abdominal massage include Mercier Therapy and Clear Passage. Clear Passage is really the holy grail with lots of research behind it for endo and SIBO, but it’s incredibly expensive, so you may be better off trying the other techniques first. However, I do highly recommend it if you can afford it! I’ve linked in the show notes how to find practitioners for all of these that I’ve just mentioned. 3. Arvigo Massage Third on our list is Arvigo Therapy, which is a form of abdominal massage that is much more gentle than the ones I just mentioned previously. The benefit of Arvigo Therapy is that you only need one session, which can be done over Zoom, to learn it from a therapist, and then you can just practice it daily at home every evening. Now in my conversation with Tara Ghosh, who is an Arvigo Therapist and actually taught me personally, she shares that whilst Arvigo Therapy doesn’t directly loosen adhesions like visceral manipulation does, it does encourage circulation to the area and helps to relax the muscles and organs in the area, which can then have the indirect effect of loosening a frozen pelvis. However, I have seen some articles by therapists claiming it can loosen adhesions, perhaps they mean indirectly or perhaps there are differing opinions, but you can listen to the interview with Tara in episode 127 to learn more. I highly recommend working with Tara because she’s just the loveliest person, and you can reach out to her directly via the details she shared in the interview (and I’ll put her Instagram in the show notes) but if you want to find another therapist, I’ve linked to the directory in the show notes. I’m pretty sure Tara sees clients from all over the world. 4. Breaking up your time sitting down Number four is all about breaking up the time you spend sitting down at your desk, specifically by using a standing desk and by taking regular breaks. Now, there’s been a lot of debate and controversy over this in the past few days. You may have seen in my stories I posted about my standing desk, which I use at varying intervals during the day, alternating between sitting and standing. I do this because my own physios and my colleagues, many of who are pelvic floor physios and my pelvic pain training, have always taught me that sitting for long periods of time without a break can worsen pelvic floor dysfunction symptoms through shortening and weaking the muscles in the area and restricting blood flow. My understanding was that sitting down for long periods of time without breaks shortens the muscles in the front of our hips and pelvis, which means when we stand, walk or do anything else that isn’t sitting, we have restricted movement, tension, tightness and are more likely to experience pain. And if we have adhesions in the area, sitting down for long periods of time lessens the opportunity to stretch them and release them, making their hold on our organs stronger and tighter. However, I had quite an strongly worded message form a physio informing me that this simply isn’t true and that muscles don’t shorten or lengthen, which absolutely threw me. So I went away and spoke to some colleagues and they all said that yes, muscles shorten and that sitting for prolonged periods of time causes this and can worsen pelvic floor issues. So I was quite confused! I wanted to dig a bit deeper to understand why this physio said they don’t and I think what it boils down to is terminology, and oversimplification to make physio language easy for patients to understand. From what I gather through my own research and conversations is that the muscles don’t actually change length, but they lose their ability to stretch so they become restricted. Here’s how one of the PTs I spoke to put it. Martha Spalding, Circle of Health Physical Therapy, CA: “Muscle length stays the same so no, they don’t elongate but they can be contracted, weak in both eccentric and concentric contractions, strained, sprained, torn and severed. Ligaments can be overstretched and they can have laxity, which is common during pregnancy and some people just have genetic ligamentous laxity. Prolonged sitting is stressful on the entire spine and pelvic floor as it is a prolonged static position in weight bearing on the pelvis. The pelvis is generally rotated posteriorly. Depending on the muscles, you can determine the stress component in the sitting position. This prolonged position does impact the fascial slings which can become restricted.” So to help understand this better, eccentric contraction means when muscle length increases from tension during a movement, like a stretch. In contrast, concentric contraction is when a muscle shortens and tenses in order to bear weight and counteract resistance, so think about lifting a dumbbell in a bicep curl. So in short, the ability to perform these contractions can become weaker. Laxity is defined as ‘looseness of muscle’, but I wouldn’t say this would be occurring here, it’s just an example she’s providing to demonstrate how muscles change. After these conversations, the physio who originally contacted me also replied to say that sitting all day without any movement would cause joint and muscle stiffness, but she was also very clear to state that there are no detrimental effects on the pelvis with sitting. So clearly there are some cross overs here, but also some differing of opinions. As I’m not a physio, I can’t really give you a definite answer so I’m providing you with the information I have gained and also what I have learned in my own time in training and working with physios. To my knowledge, yes, sitting without breaks and movement can have an impact, but I’ll leave it to you to decide. My practice is to alternate between sitting and standing throughout the day, as I feel comfortable. When I start to feel tired and my legs need a break, I sit down, and when I feel like I’ve been sitting for long enough, I stand. And every 30 minutes to an hour of sitting at my desk working, I get up and do some form of movement, usually it’s a couple of minutes of rebounding, stretching, walking around the house or a few minutes of exercise and literally it’s just like 3 to 5 minutes. Now I appreciate that if you have chronic pelvic pain and a weak core from pelvic floor dysfunction and from living with chronic pain, that using a standing desk can be difficult to do. So I suggest starting when only you’re ready with smaller periods of time to build up the strength in the core and to also have a cushioned mat under your feet or cushioned slippers to soften the impact. If you need to first spend some time just practicing taking breaks with gentle movement to build up your strength, or if you need to do some physio first or work on pain alleviation, do that first. This is just an option and you have to do what feels right for you – don’t rush into using a standing desk just because I’ve talked about it today, make sure it’s the right choice for you. If you do buy a standing desk, you should also be swapping your positions when you’re standing up, so you’re not just constantly bearing down on your joints. I’ve linked to a helpful article in the show notes on different positions to adopt and how to stand in a healthy way when using a standing desk. There’s now mounting information on the health risks of sitting for long periods of time without breaks or movement, including heightened inflammation, which you guys know is super important for us to keep on top of, so if you’re employed by a company, they really shouldn’t be surprised by you asking for a standing desk. And in fact, it should fall under reasonable adjustments to help make you feel more comfortable when living with endometriosis. If you have trouble getting your company to agree, I suggest having a listen to my interviews with Vickie Williams and Clare from See Her Thrive, which are both about your rights as an employee with endometriosis in the workplace. If you’re curious to learn more about the health considerations and research behind prolonged sitting, I’ve linked to a couple of articles in the show notes. If you’re self-employed like I am, you can easily order a standing desk online. Prices range dramatically from whole desks which adjust to become either a seated or standing desk at about £1000 or cardboard desk toppers that you just put on top of your desk, and that you rest your keyboard and computer or laptop on, and these are around £15. If you’re not quite ready for a standing desk or you’d like something extra to support your pelvis further when sitting, it’s best to take a quick break from sitting every 30 minutes if possible. I recently spoke to Rachal Dutton, The Period Whisperer, and she suggested getting up and doing hip circles both clockwise and anticlockwise for a minute or so or doing cat cow stretches whilst still in your chair. There are tonnes of movements you can do whilst seated to give your pelvis a quick break, so if you’d like more options, do some extra research until you find some that suit you! To bring this unusually controversial tip to an end, I want to reassure you that if you need to sit down or lay down regularly, it’s okay. The key really is about trying to add in healthy movement as and when your health allows, and to take frequent short breaks from the sitting position, again as and when your health allows. I understand that there are days when all you can do is stay curled up, I’ve been there too! But on the days when you feel stronger, consider some small movements like rotating your hips or a quick cat cow to break things up a bit. 5. Pelvic floor stretches You knew I was going to go there. Pelvic floor physio stretches are essential, in my opinion, to loosening adhesions and freeing up a frozen pelvis. Of course, in an ideal world, we’d all go to pelvic floor physiotherapists who can give us tailored stretches to do daily at home, but that’s not an option for some people on smaller incomes. So if that’s you, you’ll be pleased to know that there are so many pelvic floor stretches for endo and chronic pelvic pain available online and in books. I’ve linked to videos, articles and books in the show notes for you to choose from, and all of these are designed by professional and specialised women’s health pelvic floor physiotherapists. What I will say is to listen to your body here. If you’re experiencing pain, or you have a strong reaction, ease up or try a different stretch – you may be currently too tight or ‘frozen’ in the pelvic area to attempt certain stretches for the time being, so start slower and allow some space and flexibility to build before attempting those pain triggering ones again. You could add these in during your day, as part of your break from sitting, or in the morning as a way to wake your body up, or in the evening to help you to wind down. Whatever it is, find a time that suits you and don’t worry, you don’t have to spend half an hour on this! Ten or even five minutes is fine! Just start and try to get them in as often as possible, daily if you can – but don’t stress if you can’t! Now of course, I don’t know your personal circumstances, so if stretching isn’t the right choice for you right now, don’t worry, try something else from this list that is. 6. Proteolytic enzymes Alright, number six is proteolytic enzymes. Proteolytic enzymes are enzymes which break down proteins into amino acids. Proteolytic enzymes, when used for healing, help to reduce inflammation post-surgery and aid in clearing waste products from the wound site, and help to reduce adhesion formation. This is because of course, the building blocks of tissue are proteins! However, because they reduce adhesion formation, there is the risk that if there is an infection at the site of the wound, that it could spread, as adhesions play a role in isolating infection sites from the rest of the body. This is rare but has been known to happen. Another thing to note is that the research is limited, with most of the research being in oral surgery or sports related injuries. The only study we have on enzymes for endo specifically is one we use commonly at IWHI and that’s Wobenzyme. Wobenzyme was shown to reduce pain and inflammation post-surgery and inhibit the formation of new blood vessels, reducing the chances of further endo development and adhesion formation. The dose used in the study was the label dose for 40-60 days pre-op and then 60 days post op. You need to take Wobenzyme away from food, otherwise the enzymes will just be used for digestion. Now most of the studies on adhesion formation are conducted pre and post-op, so I really can’t say whether they’d make a difference if you surgery was five years ago for example, my instinct is that they wouldn’t aid with the adhesions but they might help with inflammation. 7. Castor oil So number seven is castor oil and this one is also a little controversial, so I’ll provide you with the info and you can make your own decision about it. I know countless leading women’s health practitioners who use castor oil to soften and break down adhesions and who experience great success with it with their clients. However, it’s generally considered that more research needs to be done, though there is research on castor oil’s abilities to lower inflammation, reduce symptoms of constipation, improve circulation, and stimulate muscle relaxation. You may have heard Arvigo Therapist Tara Ghosh break it down in my interview with her. She explained that castor oil actually triggers the immune system, due to some of its chemical components, however, on responding to the call and finding no poison to clear, the immune system goes about utilising its tools on repairing and healing the pelvic area, which in turn helps to break down and clear adhesions. She also emphasises that the lowering of inflammation and improving of blood flow to the area, thanks to castor oil, is part of how this process works. She’s not the only fan either. I had a conversation about castor oil with my colleagues and so many of them used castor oil packs to break down adhesions, and Nicole Jardim is a fan of using them for endometriosis and period pain. So if you want to learn how to make your own castor oil pack and how and when to safely use them, I advise listening to my interview with Tara who has a really quick and easy method as opposed to the often messy and sticky traditional approach! 8. Heat Therapy Last up is heat therapy. Yet another controversial one. Heat therapy is often used by practitioners to help loosen fascia, muscles and break down adhesions. I recently spoke to Rachel Dutton who strongly recommended it to me to help with the lower right side of my pelvis, which is really stuck and isn’t responding well to body work therapy because it’s just too frozen and so I need to start with a gentler approach. She explained to me that heat therapy stimulates blood flow, which as a result helps to break down scar tissue and suggested this as one of the first options I should try. Additionally, increased blood flow will allow the muscles to relax as more oxygen is delivered and so any muscles which were contracting due to restricted access to oxygen, which is common when you have a tight, bunched up pelvis, can start to loosen and become more mobile. There’s also research showing how heat therapy can prevent adhesions from building up so much after injury. Unfortunately PubMed was down at the time of writing this, so I haven’t got a tonne of studies to stick in the show notes but I’ve put in a few articles and one or two studies, and of course you can do some of your own research as well. So now the controversy comes in. Some sources, but not many, claim that heat can loosen adhesions and fascia and then as they cool, they stiffen up again, and become stiffer than before. I dug into this further and honestly, I couldn’t really decipher how they sources came to that conclusion, and I spoke to multiple colleagues about this who were equally as baffled and looked at the articles with me, and didn’t really feel the claims were fully supported. However, one research paper does discuss the rebound phenomenon, where the positive effects of heat therapy are actually only present for 20-30 minutes. So for 20 to 30 minutes, blood vessel dilate and blood flow increases, but afterwards, the blood vessels actually start to constrict again, preventing blood flow, so this is definitely worth taking into consideration. After I raised this to my colleagues, they all agreed that they only use heat therapy for 20 to 30 minutes in terms of hot water bottles, normally applied alongside castor oil packs and perhaps alongside a massage therapy treatment. They were also very keen to stress that they never use boiling water in a hot water bottle, only warm water. However, I’m curious about whether we can go a step further than hot water bottles. For a long time now, I’ve been very interested in the research behind infrared therapy, which has been shown to heal muscle injury, tissue damage and lower inflammation. For this reason, I’ve been really curious about infrared sauna belts and infrared heat pads for my chronic bladder pain, because they have so many benefits, but I just haven’t bought one yet as I’m spending so much on SIBO healing. The prices that I have seen range between £50 and £60, so not that expensive, but for some of us a hot water bottle is the more affordable choice. So whilst I can be sure about the theory that adhesions and muscles get worse after heat therapy, clinically, heat therapy seems to achieve remarkable results, especially when combined with castor oil packs and massage. Of course, if you’re going to use hot water bottles, just keep it to less than 30 minutes and don’t use water straight off the boil. I think a wonderful way to try heat therapy is to use heat 30 minutes prior to a home massage, like Arvigo Therapy, to relax and soften the muscles so they’re more pliable and open to movement and stretch. So I hope that has given you some ideas to help you soften your fascia, loosen adhesions and release a frozen pelvis. Remember, what works for one may not work for another, always listen to your body and be guided by what it’s telling you and ideally, consult a practitioner if you can afford to do so. I would love to hear which strategies you try and how you get on! Please remember I am not a physiotherapist or a masseuse. This information comes from my training as a health coach, my conversations and interviews with leading pelvic floor physios and my experiences a patient. This podcast is here for educational purposes only. Let's get social! Come say hello on Instagram or sign up to my newsletter. This episode is sponsored by my free guide ‘A Natural Pain Relief Tool Kit for Endometriosis’. This four page guide includes evidence based and effective remedies which you can use at home to reduce your pain with endo. Download your copy here. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. This episode is sponsored by The Pod Farm. Learn all about how to start your own podcast with the complete course from The Pod Farm. Aimed at beginners, this course takes a simple and straightforward approach to planning, equipment buying, setting up, recording, editing and hosting your own podcast. With hours of audio and video materials, and downloadable guides and useful links, this multimedia approach aims to have something for every kind of learner. From now until April 15, newsletter subscribers get 20% off the course price. Visit www.thepodfarm.com to enroll or find out more This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk Show Notes Adhesions https://pubmed.ncbi.nlm.nih.gov/11528133/ Foam Rolling https://www.youtube.com/watch?v=xJOzcFS6fGE https://www.youtube.com/watch?v=umTObqSYay0 https://www.youtube.com/watch?v=V6cR3knKFIA Visceral Manipulation https://www.iahp.com/pages/search/index.php https://clearpassage.com https://www.merciertherapy.com (You currently need to email them directly for a referral) Arvigo Therapy https://www.arvigotherapy.com/team-members Sitting https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/sitting/faq-20058005 https://www.nhs.uk/live-well/exercise/why-sitting-too-much-is-bad-for-us/ https://www.startstanding.org/standing-desks/10-standing-desk-mistakes/#positions Stretching https://www.youtube.com/channel/UCXigFK5hLLF82uZ72jzTvmg/videos https://www.harpercollins.com/products/beating-endo-iris-kerin-orbuch-mdamy-stein-dpt?variant=32903931691042 https://thepelvicexpert.com/blog/6-simple-exercises-to-ease-endometriosis/ Heat Therapy https://pubmed.ncbi.nlm.nih.gov/31115522/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214933/ https://www.researchgate.net/publication/300270473_Superficial_Heat_and_Cold_Applications_in_the_Treatment_of_Knee_Osteoarthritis Castor Oil https://nicolejardim.com/castor-oil/
Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. * * * Deeper Dive Resources Organixx Enzymes 17 https://organixx.com/p3e?gl=5e29babe02e26bdb05020909 Proteolytic Enzymes https://www.britannica.com/science/proteolytic-enzyme What Is the pH of the Stomach? https://www.thoughtco.com/ph-of-the-stomach-608195 National Center for Health Statistics https://www.cdc.gov/nchs/fastats/digestive-diseases.htm Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases Collagens: Hype or Healthy – Episode 15 https://organixx.com/empowering-you-organically/collagens-hype-or-healthy-episode-15/?gl=5d37204c02e26bc012183af2 Subscribe to Empowering You Organically Never miss an episode! 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Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. * * * Deeper Dive Resources Organixx Enzymes 17 https://organixx.com/p3e?gl=5e29babe02e26bdb05020909 Proteolytic Enzymes https://www.britannica.com/science/proteolytic-enzyme What Is the pH of the Stomach? https://www.thoughtco.com/ph-of-the-stomach-608195 National Center for Health Statistics https://www.cdc.gov/nchs/fastats/digestive-diseases.htm Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases Collagens: Hype or Healthy – Episode 15 https://organixx.com/empowering-you-organically/collagens-hype-or-healthy-episode-15/?gl=5d37204c02e26bc012183af2 Subscribe to Empowering You Organically Never miss an episode! 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Show notes at https://thesternmethod.com/mary-swander Mary Swander is an award-winning American author, dramatist, performer, speaker, and teacher. She is the former Poet Laureate of Iowa and a professor emerita Distinguished Professor of Iowa State University. Mary is the Artistic Director of Swander Woman Productions, a theatre troupe that performs dramas about food, farming, and the wider rural environment. She is also the Executive Director of AgArts, a nonprofit designed to imagine and promote healthy food systems through the arts. Her latest book is The Maverick M.D.: Dr. Nicholas Gonzalez and His Fight for a New Treatment for Cancer (New Spring Press). The Maverick M.D. is the story of how Dr. Nick Gonzalez perfected the scientific theory behind Dr. William Kelley's work and put the protocol into practice in New York City. Gonzalez drew courage from his Christian faith, from Mexican-Italian-American family, and from key loved ones, colleagues and mentors. He spent years treating patients with the most serious conditions--from cancer to diabetes to lupus. But he wasn't satisfied as an outlier in the medical community. He wanted his work put to the test with a clinical trial. This book portrays a man who fought for the acceptance of a nutritional cancer treatment in the halls of some of the most established U.S. medical institutions. Against intense opposition, Nick Gonzalez's determination held up until the end--a scientist who developed a therapy that saves lives and promotes the healing of the human mind, body and spirit. ***Resources Mentioned*** Mary Swander Swander Woman Productions Agarts: Imagine a healthy food system New Spring Press Nutricology Pancreas Pork Natural Glandular Capsules Nutricology ImmoPlex Natural Glandulars The Nicholas Gonzalez Foundation The Maverick MD *** In This Episode: Ryan takes a candid look at Dr. Nicholas Gonzalez’s life and “the man behind the suit” in the discussion with his biographer, Mary Swander. You’ll learn about why Ryan thinks so highly of Dr. Gonzalez, his life and personality, the Gonzalez Protocol and the results it produced. Ryan and Mary delve into Dr. Gonzalez’s attempts to take his enzyme therapy protocol to clinical trials in the conventional medical arena. They also discuss Mary’s experience as a patient of Dr. Gonzalez for over 20 years. You’ll gain insight into the brilliant mind of Dr. Gonzalez, his spiritual life, his concept of balance, and his mysterious death. And speaking of brilliant minds...at the end, you’ll be treated to a special creation by Ryan’s son, Ryder! Timestamps: 2:35 How Ryan learned about Dr. Nicholas Gonzalez Dr. Gonzalez was speaking at The Truth About Cancer conference Smartest guy in the whole field - genius Didn’t consider himself an integrative medical practitioner Helping people with cancer and other degenerative diseases Ivy-league doctor, traditional medical training 5:15 What was the paradigm shift which caused Dr. Gonzalez to go into the realm of unconventional medicine? His two loves : literature/arts and medicine Accomplished investigative journalist - worked for Time, Inc. Linus Pauling encouraged him to go to medical school after an interview Sloan Kettering Medical School When Dr. Gonzalez’s father got cancer, he stood beside his father’s death-bed and vowed he would find a cure for cancer. Met dentist William Kelley who had cured himself from pancreatic cancer Dr. Gonzalez wanted to know how Dr. Kelley cured himself and his patients - went to Texas to investigate how Came back to Sloan Kettering and tried to prove Dr. Kelley’s method in the conventional setting Wanted clinic trials but conventional medicine wasn’t cooperative Dr. Gonzalez had family in Mexico and could have gone there to practice alternative medicine but wanted to stay in the US. 11:45 Mary Swander’s experience as a patient of Dr. Gonzalez Dr. Gonzalez passed away in 2015 MaryBeth Gonzalez (widow) has worked hard to keep his legacy alive Mary Swander was patient of Dr. Gonzalez for 20 years Group of scientists with breast cancer wanted to work with Dr. Gonzalez to heal metastasis On the advice of a friend, Mary worked with Dr. Gonzalez to clear up her fibrocystic tumors and to build up her depleted immune system Mary didn’t want people to forget Dr. Gonzalez and his work. She felt a book needed to be written about his life and therapy. Dr. Gonzalez’s widow, Mary Beth, agreed. 17:00 What surprised Mary about Dr. Gonzalez’ life During the time Dr. Gonzalez was a journalist, he used to read a book a day. He researched and was fascinated with ecology As a child, Dr. Gonzalez used to spend his summers camping at Lake George, NY. The rest of the year, his family lived in NYC. Went to Brown University but transferred for a short time to Cornell to study agriculture Read Sir Albert Howard and other sustainable agricultural teachers Thinking holistically at a very young age 21:25 The experience of trying to explain unconventional healing to conventional medical practitioners Dr. Gonzalez identified 12 different metabolic types Dr. Gonzalez was very “balanced” on his own scale of metabolic types Dr. Gonzalez’s grandparents were immigrants, exceptionally bright and accomplished. Mexican-Italian heritage. Ancestors helped lead the Revolution in Mexico and included accomplished musicians. Story of how Dr. Gonzalez’s grandfather almost didn’t make it through customs at Ellis Island but succeeded by playing the cello in the customs building halls. Anthropologist Margaret Mead said it takes 3 generations to create the super-accomplished person and Dr. Gonzalez was just that. 25:00 Combining the physical with the meta-physical/spiritual world The archetype of the wounded healer - physical wounds and healing can lead to spiritual awareness, healing, transformation Not only was Dr. Gonzalez incredibly bright and balanced, he was also very spiritual Dr. Gonzalez spent a lot of time with his patients and always had a Bible nearby Dr. Gonzalez grew up Catholic and became fascinated with the Bible during his first marriage He had a photographic memory and became a biblical scholar 29:00 Dr. Gonzalez’s personality and drive to develop his program Small in stature, athlete, fighter, quick and motivated, driven Part of the program is use of pancreatic enzymes Dr. Gonzalez learned about enzymes from Dr. William Kelley The enzymes are formulated in a precise way - Dr. Gonzalez worked on this for years Pancreatic enzymes go back to the end of the 19th century with a biologist (embryologist) named John Beard, DSc in Scotland Beard studied placental growth and embryonic development and theorized pancreatic enzymes might control tumor growth in the same way they control the growth of the placenta At the turn of the 20th century, pancreatic enzymes were being used with modest success Beard was forgotten about after Marie Curie’s discovery of radiation Dr. Gonzalez’s enzymes are still in production through NutriCology Dr. Gonzalez had to finance his own research Number of enzymes and frequency taken varies with the type of condition Everyone on the program does coffee enemas to help detox Dr. Gonzalez asked the Merk Manual editors why they took coffee enemas out of the manual (lack of space) Protocol uses liver and colon cleanses, some juicing Dr. Gonzalez’s widow Mary Beth is working to formalize the Gonzalez program and train doctors in the protocol Metabolic scale/typing determines which diet is used on the protocol 46:55 Balance is key Acid v. alkaline - don’t go off the scale in either direction The genius of Dr. Gonzalez and Dr. William Kelley Not possible to use same protocol for everyone because of unique metabolic types 12 different diets with 99 variations 51:24 Metabolic typing Testing and bloodwork pH Personality type Physical characteristics Ancestry Geographical location 57:05 Dr. Gonzalez’s thoughts on meat Didn’t look as much at individual (chemical) components of foods as he did using foods to bring the body back into balance Eliminate the whole food dislikes- listen to your body 1:02:15 Clinical study of the Gonzalez protocol Dr. Gonzalez worked most of his earlier career trying to find funding for his clinical trials (Nestle, Proctor and Gamble) Nestle funded a study by Dr. Gonzalez and Dr. Linda L. Isaacs on pancreatic cancer and enzymes published in medical literature Encouraged by doctors at the NIH to do a clinical trial Trial took place at Columbia University over course of 10 years Dr. Gonzalez wrote a book called What Went Wrong because so many procedures weren’t followed In the end, researchers at Columbia published a paper which said the protocol didn’t work Success of the protocol often depends on the compliance of the patient Dr. Gonzalez didn’t cure everyone who walked through his doors 1:09:33 Mystery surrounding Dr. Gonzalez’s death News articles are not definitive Facts of the death (not conspiracies) are in the book Autopsy and second round of tests were performed Heart attack was ruled out Died suddenly at age 67 Not much reliable information on the internet about Dr. Gonzalez 1:13:45 Book: The Maverick MD Engaging book Readers want to know when the movie is coming out Book available on Amazon and New Spring Press Gonzalez Foundation- widow Mary Beth working to bring into print all the books Dr. Gonzalez was writing 5 books published so far 1:17:00 Picking up the torch where Dr. Gonzalez left off 1:19:30 Ryder’s first knitting project :) If you have a question or comment about this episode let us know below!! Keywords Volume CPC PPC SCORE Pancreatic enzymes 27100 1.3 .87 45 Enzyme therapy 1300 1.11 .9 41 Alt:pancreatic enzyme replacement 1000 1.62 1.0 42 Alt:enzyme treatment 720 1.07 1.0 26 Proteolytic enzymes 9900 .91 1 48 Alt: Proteolytic 18100 1.37 .02 49 Alt: Enzymes proteolytic 27100 1.15 .96 43 Alt: Enzyme supplements 5400 1.85 1 49 Enzymes 165000 .47 .78 64 Digestive enzymes 90500 1.39 1 59 Gonzalez protocol 90 1.1 .16 37 Dr. Nicholas Gonzalez 590 1.13 .11 37 Dr. Nicholas Gonzalez death 480 3.36 .12 24 Nicholas Gonzalez Foundation 10 .78 .04 33 Maverick MD 0 Mary Swander 70 0 .03 39 Mary Swander author 0 Metabolic typing 9900 .67 .06 37 Dr. William Kelley 90 0 .04 31 Nutritional cancer treatment 110 3.49 .45 50 Nutritional therapy for cancer 210 1.45 .5 44 Alternative cancer treatment 4400 7 .03 51 Dr. Linda Isaacs 290 0 .02 25
Proteolytic enzymes have been used as part of many popular natural health protocols for decades now… But why have they been gaining more popularity over recent years? The truth is that the research is now concrete on their ability to assist in healing many hard to treat health issues… On today’s #CabralConcept 1775 I explain why they’re so effective and reveal “the miracle” of serrapeptase & proteolytic enzymes - Enjoy the show and let me know what you thought! - - - Show Notes & Resources: http://StephenCabral.com/1775 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - - Dr. Cabral’s Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.01.258665v1?rss=1 Authors: Garcia-Gonzalez, L., Paumier, J.-M., Louis, L., Pilat, D., Bernard, A., Stephan, D., Jullien, N., Checler, F., Nivet, E., KHRESTCHATISKY, M., Baranger, K., Rivera, S. Abstract: We have previously discovered the implication of membrane-type 5-matrix metalloproteinase (MT5-MMP) in AD pathogenesis. Here we shed new light on pathogenic mechanisms by which MT5-MMP controls APP processing and the fate of amyloid beta peptide (A{beta}) and its precursor C99. We found that MT5-MMP in HEK carrying the APP Swedish familial mutation (HEKswe) processed APP to release a soluble form of 95 kDa (sAPP95). This process was hampered by the removal of the C-terminal non-catalytic domains of MT5-MMP. Catalytically inactive MT5-MMP variants increased the levels of A{beta} and promoted APP/C99 sorting in the endolysosomal system. We found interaction of C99 with the C-terminal portion of MT5-MMP, de deletion of which caused a strong degradation of C99 by the proteasome, preventing A{beta} accumulation. These findings reveal novel mechanisms for MT5-MMP control of APP metabolism and C99 fate involving proteolytic and non-proteolytic actions mainly mediated by the C-terminal part of the proteinase. Copy rights belong to original authors. Visit the link for more info
Delayed onset muscle soreness (DOMS). It's that deep ache in your legs that makes it challenging to sit down without holding onto the arms of a chair, or the pain in your chest when you hug someone in the days following an intense workout. The good news is, it means you did something in the gym that'll help build muscle. The bad news is, you might need to endure the pain for a day or two. In this blog post, I've outline what doesn't work, what might work, and what does work to deal with sore muscles and speed recovery. What Is Delayed Onset Muscle Soreness? Delayed onset muscle soreness (DOMS) is the pain, stiffness, and slight swelling you feel in the hours or days following an intense exercise session. DOMS is classified as a type I muscle strain injury and presents with tenderness or stiffness to palpation and/or movement."Cheung K et al. Delayed Onset Muscle Soreness. 2012 It is usually triggered by: Starting a new training program after a layoff or for the first timeHigher-rep or higher-volume trainingEccentric or ballistic training (weights, downhill running, plyometrics, etc.)Any other intense physical activity you might not be accustomed to (golf, moving furniture, gardening, etc.) The soreness hits you 12-36 hours after your training session or physical activity. What causes delayed onset muscle soreness? According to the most current research, there are six possible causes of delayed onset muscle soreness: Lactic acid accumulation: Lactate accumulation creates the burning sensation you feel when completing dozens of squats or pushups. Most people feel sore following these types of workouts, which led researchers to believe lactate accumulation contributes to DOMS. However, concentric-only exercise can create significant lactic acid buildup but rarely causes DOMS. Also, you metabolize lactic acid within an hour following training, and DOMS doesn't even show up for many hours after that.Muscle spasm: The muscle spasm theory suggests that your muscles go into a minor spasm following intense training. The microscopic contractions are small, but significant enough to trigger nerves and cause pain, which causes the muscles to spasm even more. Research on this theory is inconclusive.Connective tissue damage: Connective tissue wraps your muscle fibers. According to this theory, muscle contraction stretches the connective tissue enough to cause microscopic injury, triggering the soreness. This theory is difficult to prove.Muscle damage: The muscle damage theory is the most-accepted of the six opinions, but it probably isn't the only factor causing muscle soreness. Following intense muscle contraction, components of muscle fibers get damaged. The damage causes an immune response and an increase in enzymes like creatine kinase (CK).Inflammation: Inflammation plays a role in any injury in the body, even a minor and beneficial injury like workout-related muscle tissue damage. Proteolytic enzymes break down the damaged tissue, while other inflammatory-related compounds, including bradykinin, histamine, prostaglandins, monocytes, and neutrophils, play other roles. All these inflammatory compounds draw fluid into the muscle, causing inflammation. Enzyme efflux: Following damage to the muscle cell, calcium escapes from the damaged sarcoplasmic reticulum, which activates proteases and phospholipases, or proteolytic enzymes. This theory suggests the proteolytic enzymes cause further damage to the area and stimulate pain-related nerves. In reality, it's probably a combination of all these theories and then some. What Doesn't Reduce Muscle Soreness Why do I include what doesn't work? Like anything else in health and fitness, there are many myths about how to reduce muscle soreness. Though the following offer other health benefits, they don't reduce muscle soreness according to the research. Cryotherapy: When it comes specifically to reducing delayed onset muscle soreness,
About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. * * * Deeper Dive Resources Organixx P3E Enzymes https://organixx.com/p3e?gl=5e29babe02e26bdb05020909 Proteolytic Enzymes https://www.britannica.com/science/proteolytic-enzyme What Is the pH of the Stomach? https://www.thoughtco.com/ph-of-the-stomach-608195 National Center for Health Statistics https://www.cdc.gov/nchs/fastats/digestive-diseases.htm Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases Collagens: Hype or Healthy – Episode 15 https://organixx.com/empowering-you-organically/collagens-hype-or-healthy-episode-15/?gl=5d37204c02e26bc012183af2 Subscribe to Empowering You Organically Never miss an episode! 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Join Jonathan and Wade Lightheart as we dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity. * * * Deeper Dive Resources Organixx P3E Enzymes https://organixx.com/p3e?gl=5e29babe02e26bdb05020909 Proteolytic Enzymes https://www.britannica.com/science/proteolytic-enzyme What Is the pH of the Stomach? https://www.thoughtco.com/ph-of-the-stomach-608195 National Center for Health Statistics https://www.cdc.gov/nchs/fastats/digestive-diseases.htm Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases Collagens: Hype or Healthy – Episode 15 https://organixx.com/empowering-you-organically/collagens-hype-or-healthy-episode-15/?gl=5d37204c02e26bc012183af2 Subscribe to Empowering You Organically Never miss an episode! 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Today’s guest is Matt Gallant, the savant-like and incredibly successful entrepreneur and CEO of BiOptimizers who has turned his life into a brain and body biohacking experiment! He is here to talk about all his practices and the supplements he uses to perform at a super high level. We begin by considering a theme that plays out through our whole conversation – the fine line between being hyperfocused and neurotically obsessed and the role gratitude plays in this. From there, we chat with Matt about the value of doubling down on one thing and how doing extensive personality tests can help in this respect. We turn our attention to the meat of our conversation next – neurofeedback, a method of clearing the limbic system of traumas and the central place it occupies in Matt’s biohacking practice. The intensive, days-long neurofeedback challenges Matt embarks on are taxing on the nervous system and we hear about the compounds he uses to help him withstand them, many of which are produced by his own company! He speaks to the extremely positive impact that his biohacking experiments have had on his relationships, well-being, and business. We are proud to say that BiOptimizers is the sponsor of our show today, and we spend the last moments of our exchange talking about a few more of their products that help to fortify the digestive tract and the benefits of this. BiOptimizers is a leader in supporting a "biologically optimized state of health" through their range of gut-health and digestive support supplements and other related products. Peruse their products at bioptimizers.com and use the code MUSCLE10 for a discount; Ben specifically recommends their MagTech product, since magnesium is a mineral vital to so many health processes that many of us are deficient in - go to magbreakthrough.com/muscle to learn more. Timestamps Introducing Matt Gallant and his work in biohacking his brain and body! [0:17] The benefits of an amazing magnesium product by BiOptimizers! [1:53] Managing the line between hyper-focus and obsession by practicing gratitude. [6:35] Matt’s gift for ideation and how he has learned the power of focusing on one thing. [9:02] How personality tests and experimenting can help you find & focus on your strengths. [14:25] Aligning your purpose, passion, and proficiency for optimizing your business. [16:44] The thrill of biologically optimized systems, not to be confused with maximized ones. [20:11] Healing from trauma and how its legacy has fueled Matt’s drive to optimize. [24:06] How these small traumas burn brain RAM and Matt’s ideal RAM level. [29:02] Learning to control your state by doing neurofeedback and other training types. [30:50] What Matt would tell his younger self at the moment his dad traumatized him. [35:00] The double-edged sword of aspirations: achievements at the cost of self-abuse. [36:00] Matt’s experiences and lessons learned doing neurofeedback boot camps. [39:09] Boosting the nervous system by taking ketone ester, magnesium, and more. [40:40] Using lion’s mane and other compounds for neurogenesis and neuroplasticity. [47:02] Being cautious when taking compounds that affect receptors like CBD and caffeine. [49:52] How to take magnesium for the nervous system and brain function. [51:12] Being calm but alert: the optimal alpha state. [52:30] Safe neurofeedback cycles ad other brain hacking methods like TMS. [53:38] How Matt’s neurofeedback has had positive effects on his life and relationships. [55:38] Breathing, mantras, gratitude, visualization: Matt’s meditation practices. [58:48] Proteolytic enzymes and products from BiOptimizers that maximize digestion [1:03:03] Stress’s effects on the digestive tract and how to fortify it using BiOptimizers. [1:08:19] Parasympathetic/sympathetic types of exercise, biohacking, neurotransmitters, emotions, lifestyles, supplements, brainwaves. [1:10:22] Where to access BiOptimizers and a special product for days of bad eating! [1:15:10]
00:08:43 - Skip setup music 00:10:05 - Sinus related issues, endotoxin, allergens in food 00:13:03 - My supplementation routine 00:15:56 - Can a person overdo sugars in the beginning? 00:18:26 - Is nizoral (ketoconazole) safe? 00:19:45 - Danny's own experience with antibiotics 00:28:43 - Shampoo for hair loss 00:29:18 - Randle cycle, food combining, oral health, SIBO, testosterone, pulse and temperature, lipid peroxidation, the bioenergetic elevator pitch, iodine 00:42:13 - Oysters how many times a week? The importance of zinc 00:44:03 - Problems with milk? What are the benefits of fasting? 00:49:39 - Danny's experience EMF 00:53:00 - Thoughts on supplemental digestive enzymes 00:55:03 - Oral health, vitamin K, vitamin D, disinfecting the intestine, CO2 00:56:12 - Bacterial and fungal issues despite good nutrition 00:58:54 - Is stinging nettle useful for hair loss? 00:59:33 - Concentration difficulties, feeling "keyed up" 01:00:32 - Hormones, smell, and taste 01:01:57 - So-called "orthorexia" 01:04:21 - Interconnection between hair loss and libido problems, testosterone, prolactin, hypothyroidism 01:07:34 - Antibiotic resistance, evolutionary foods, amino acid recycling 01:10:41 - What's Danny's life like in Thailand? 01:12:43 - Thoughts on the safety of Mexico 01:16:36 - The effects of living at high altitude 01:17:34 - Muscles as fatty acid sinks 01:18:27 - The bioenergetic view of heavy metal detox 01:21:55 - Vegetarian alternative to liver, exercise, food additive gums, working with a traditional MD 01:24:07 - Proteolytic enzymes for scalp fibrosis? 01:24:34 - Correcting the hypercarotenemia of hypothyroidism 01:26:05 - Danny's opinion of Stephanie Buttermore's "all in" approach to health 01:27:33 - A bioenergetic view of paralysis 01:27:45 - Danny's thoughts on Weston A. Price 01:31:04 - Danny's thoughts on food combining 01:32:06 - Any way to mitigate Tourettes? 01:32:17 - Water loading, prolactin, libido, hypothyroidism 01:35:39 - Why do some people experience hair loss while others do not? 01:38:42 - Can phytoestrogens reduce estrogen? 01:38:17 - Supplemental creatine 01:40:20 - Alopecia areata, vitamin D 01:42:15 - Vitiligo, finasteride, estrogen, food for kids 01:43:22 - What does Danny think about inversion tables? 01:43:34 - Does no one have any success on the bioenergetic approach to pattern baldness? 01:51:28 - Varicocele, nitric oxide 01:52:40 - Danny hasn't experimented with his casein yet 01:54:28 - Danny's thoughts on the changing society
Having trouble with your gout? In this video you will learn about foods that trigger gout, the best gout diet to get rid of it, and more! ▸ [FREE]
Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down the all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity.
Join Jonathan and Wade Lightheart dive deeper into understanding how enzymes are critical to your health and vitality. We really help you understand what you are looking for in an effective enzyme supplement. Tune in to understand what proteolytic means, the various enzymes needed in your digestive tract, the powerful punch of AstraZyme™, and why cultured enzymes matter. About Wade Lightheart 3-Time Canadian All Natural Bodybuilding Champion who competed as vegetarian, former Mr. Universe Competitor, host of The Awesome Health podcast, Wade Lightheart is one of the world’s premier authorities on Natural Nutrition and Training Methods. Having majored in Sports Science at the University of New Brunswick, he has authored numerous books on health, nutrition and exercise which have sold in over 80 countries. Wade also serves as an advisor to the American Anti-Cancer Institute. He’s been in the health industry for over 25 years, coached thousands of clients, and is sought out by athletes and high-performance oriented individuals worldwide for his advice on how to optimize their health and fitness levels. What Are Enzymes? ENZYME - noun BIOCHEMISTRY a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction. There are approximately 25,000 different enzymatic functions in the body The number of enzymes that you have present in your body is directly proportion to the amount of chemical reactions that you can engage in in the body. The difference between stones, plants, and people is enzymes, the amount and the role of those enzymes. They are the most critical component to all metabolic transactions. Enzyme Bank It's like having a bank account. In other words, your ability to write metabolic checks, to build, to repair, to heal, to digest your food, to make your hormones work, to break down the smallest chemical reactions, to make your skin nice, you name it, requires an enzymatic pathway. What is a PROTEOLYTIC enzyme? also called protease, proteinase, or peptidase, any of a group of enzymes that break the long chainlike molecules of proteins into shorter fragments (peptides) and eventually into their components, amino acids. Proteolytic enzymes are present in bacteria, archaea, certain types of algae, some viruses, and plants; they are most abundant, however, in animals. The two major groups are the exopeptidases, which target the terminal ends of proteins, and the endopeptidases, which target sites within proteins. What to Look for in an Enzyme Supplement Loaded up with proteolytic enzymes Make sure it covers the various pH levels of digestion; 3.0, 4.5 & 6.0 Contains amylase to break down your carbohydrates Contains alpha galactosidase, which will help break down some of the sugars that you will find in food Contains glucoamylase, another one that'll cover the different range of sugars that you might consume inadvertently Invertase, maltase, to help with hidden sugars that cause interruptions and metabolic problems and blood sugar issues Contains lipase to break down fats Contains phytase to break down plant fibers Contains hemicellulose and the cellulase, which will actually break down those difficult proteins that are actually a fibrous protein Contains lactase for people that can't digest milk (it's because they don't produce lactase) Contains AstraZyme™ to bolster all the benefits Enzymes are cultured What is AstraZyme™ We studied Chinese medicine and found out there is a particular root, called the astragalus root, that is used in almost every single Chinese compound. When we found out why it was used, that it turns out that that particular root actually activates and accelerates, it increases the potential of the enzymatic response. So, we took that extract through this into that formulation as well and precise dosages. And that gave a 30 to 60% boost depending on the enzyme and its effectiveness. What is a Cultured Enzyme? A cultured enzyme means this is an enzyme grown on a very specific medium that allows you to increase the potency over a normal enzyme from 100 to 1000 times. This process takes about eight weeks to get that kind of potency. So just like if you were fermenting beer or wine or something, you've got to let it work for a period of time before you get that premium spirit. It's the exact same process inside of the enzyme formula. We’re fermenting and creating a specific medium and then extracted enzymes. No chemicals are used in the extraction process. So, you just get the pure working enzymes to deliver an incredible result. What happens if I don't have the protease in my body to break down all the protein that I'm ingesting? Gas Bloating Skin problems Brain fog The reason? Because you're feeding bad bacteria who are producing a variety of endotoxins inside the body that are interrupting your natural activity.
Full Shownotes: MelanieAvalon.com/BiOptimizers Stuff I Like: MelanieAvalon.com/StuffILike 2:00 - MASSZYMES: Go To Masszymes.com/melanieavalon With The Coupon Code Melanie10 To Get 10% Discount On Your Order! 02:15 - FOOD SENSE GUIDE: Get Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Amine, Histamine, Glutamate, Oxalate, Salicylate, Sulfite, Thiol, Lectin, FODMAP, and Gluten Status! Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 2:55 - LISTEN ON HIMALAYA!: Follow The Melanie Avalon Podcast In Himalaya For Early Access 24 Hours In Advance! 03:10 -IF Biohackers: Intermittent Fasting + Real Foods + Life (Melanie Avalon): Join Melanie's Facebook Group To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 03:30 - BEAUTY COUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Black Friday SALE: 15% Off Sitewide With Free Shipping! Shop At Beautycounter.com/MelanieAvalon To Receive A Free Beauty Counter Gift From Melanie! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beauty Counter Email List At MelanieAvalon.com/CleanBeauty 6:30 - Biohacking Frameworks: The BiOptimization Triangle: Asthetics, Performance, And Digestion/Health 9:45 - The Biggest Mistake When Switching To A New Diet 12:20 - Toxins From Our Gut 14:00 - Carnivore And Plant Toxins 15:45 - What Is A Healthy Approach To Biohacking? How Intuitive Should Diet Be? 19:30 - Competition Bodybuilding, Yo Yo Dieting, And The Consequences Of Aesthetics Only 28:30 - Glycemic Response Individuality And Seasonal Variability 36:00 - Overcoming Extreme Dietary Protocols: Can You Always Return To Health? 46:20 - The Levels Of TransHumanism : Bioenhancement & Biotransformation 50:00 - Changes In Women And Reproduction Choices 52:15 - The Cons And Potential Pros Of GMOs 54:00- How Pesticides Affect Our Gut Bacteria 56:35 - JOOVV: Red Light And NIR Therapy For Fat Burning, Muscle Recovery, Mood, Sleep, And More! Use The Link Joovv.com/Melanieavalon With The Code MelanieAvalon For A Free Gift From Joovv, And Also Forward Your Proof Of Purchase To Contact@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine! 59:20- What Are Enzymes? 1:00:15 - The Enzyme Potential Of The Body And Food Today 1:04:45 - The Purpose Of Plant Enzymes 1:06:00 - The Human Color Vision Connection To Fruit 1:09:10 - Using Enzymes For Exercise Recovery, Neurotransmitters, Combatting Protein Accumulation 1:11:45 - Proteolytic Enzymes While Fasting 1:17:15 - Food Vs. Supplemental Vs. Cultured Enzymes 1:25:15- Is There A Danger To Taking Too Much Enzymes? 1:26:40 - How To Maximize Digestion With Enzymes + HCL + P30M 1:29:15 - Supplement Dosing Protocols 1:33:15 - Using Enzymes To Gain Weight (Bodybuilding) Go To Masszymes.com/melanieavalon With The Coupon Code Melanie10 To Get 10% Discount On Your Order!
Cardiac troponins are recognized as the primary biomarkers used in the diagnosis of acute myocardial infarction. These are commonly detected by immunoassays, which offer the wide availability and rapid results needed in clinical care scenarios to rule out myocardial infarction. However, immunodetection methods can be limited when there is degradation of the target analyte, as is the case with cardiac troponin I. Early studies suggested that the central region, located between amino acid residues 30 and 110, was the most stable part of the molecule. This was a driver for the majority of current diagnostic systems to utilize antibodies with epitopes located within the central region. A down side to this approach is that auto antibodies also bind to this region, potentially causing interference and erroneous results. As more recent studies have identified additional cardiac troponin I proteolytic fragments, it is important to understand their composition and prevalence in the blood of patients with acute myocardial infarction. Furthermore, there is a need to evaluate whether monoclonal antibodies specific to the regions beyond the central section of the molecule can be used to develop cardiac troponin I assays with improved performance over those currently available. An original article appearing in the July 2018 issue of Clinical Chemistry describes a study investigating these concepts.
Digestive enzymes might be the most overlooked, underappreciated part of a good nutrition plan. Even the healthiest diet does little if you don't have good digestive health. Unfortunately, most people don't think about using them unless they have issues with their gut health. As you'll see, they're essential for more than breaking down the food you eat. They can play a role in weight loss, muscle growth, and aging well. Not surprisingly, they're part of my Foundational Five. About 20% of the US population is known to have a digestive issue. That's about 60-70 million people. The percentage continues to grow in the US and across the world. Symptoms can be as subtle as gas and bloating to more extreme symptoms like constant diarrhea or intermittent pain. Exercise, increased core body temperature, injury, stress, and certain diseases can compromise enzyme production. Processed foods may deplete enzyme activity and availability. Digestive enzyme insufficiency may contribute to: Irritable Bowel Syndrome (IBS)hyperthyroidismCeliac diseaseCrohn's disease Excessive exercise and diets high in processed foods contribute to a lack of enzymes. What are Digestive Enzymes? Enzymes speed up chemical reactions in the body. You use more than 5000 different enzymes every day. Most of those enzymes are metabolic enzymes, responsible for everything from your thoughts to the thickness of your blood. A relatively small group of your 5000 enzymes convert the food you eat to nutrients that fuel and build your body. Without digestive enzymes, you wouldn't break down protein, fat, and carbohydrates, and your foods would pass through you undigested. Along the way, the food would destroy your intestines' lining, cause immune reactions, and cause inflammation. Nutritionally, you'd starve, no matter how much food you ate. Digestive enzymes fall into three different categories, based on the macronutrient they act on: Proteases and peptidases: Convert protein to peptides and amino acids. They also act on other parts of the body to support normal immune function, inflammation levels, tissue repair, and blood viscosity.Common proteases and peptidases: Bromelain, Pancreatin, Papain, Peptidase, Protease, TrypsinCarbohydrases: Convert carbohydrates to glucose and fructose.Common carbohydrases: Alpha-galactosidase, Amylase, Cellulase, Diastase, Glucoamylase, Invertase, Lactase, PhytaseLipases: Convert fat to fatty acids.Common lipases: Lingual Lipase, Gastric Lipase, Pancrealipase Proteases and Peptidases (Proteolytic Enzymes) Proteases (also known as proteolytic enzymes) act on protein in the digestive system. However, they also affect many other areas of the body. The average healthy adult breaks down 250-300 grams of protein throughout the body every day. Your body does this to replace damaged or aged tissues with new ones. Proteolytic enzymes play an essential role in this process. They also help maintain healthy inflammation levels, modulate pain, and support normal immune function. Because the body can produce a limited number of proteolytic enzymes, demand can exceed supply. Following an injury or extreme physical stress, proteolytic enzymes can be directed to the tissue repair, leaving the digestive system without enough to complete digestion. This could be why athletes often deal with digestive issues. If they don't get extra proteolytic enzymes through food or supplements, their available enzymes take part in tissue repair, leaving them short on what they need for proper digestion. On the other hand, in some people, enzymes are directed to digestion, leaving the rest of their body short. In this case, inflammation could get out of hand, or tissues and joints could get irritated. When supplemented in the diet, proteolytic enzymes have been shown to reduce stiffness and exercise-related soreness.* European practitioners regularly recommend proteolytic enzymes to support overall healt...
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06
Fri, 6 Jun 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/18577/ https://edoc.ub.uni-muenchen.de/18577/1/Dau_Therese_Thuy_Dung.pdf Dau, Thérèse Thuy Dung ddc:570, dd
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19
Thu, 23 Jan 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/17796/ https://edoc.ub.uni-muenchen.de/17796/1/Taverna_Mara.pdf Taverna, Mara
Click to Subscribe to All Ben's Fitness & Get A Free Surprise Gift from Ben. Click here for the full written transcript of this podcast episode. Do you have a future podcast question for Ben? Scroll down on this post to access the free "Ask Ben" form... In this June 1, 2011 free audio episode: Estrogen dominance, indoor trainer vs. stationary bike, achilles pain, natural anti-inflammatories, dimethylamylamine in supplements, Juice Plus, Mona Vie, and shaky hands. Remember, if you have any trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com. And don't forget to leave the podcast a ranking in iTunes - it only takes 2 minutes of your time and helps grow our healthy community! Just click here to go to our iTunes page and leave feedback. Scroll down to donate anything over $15 to the show, and Ben will send you a BenGreenfieldFitness.com t-shirt...you can also conveniently donate any amount with your phone by simply clicking here. --------------------------------------------------------------- Featured Topic: "Why You Shouldn't Slap Any Old Sunscreen On Your Skin." In Episode #92: The Things You Always Wanted to Know About Sunscreen, But Were Afraid to Ask , I interviewed Dr. Nic Martens about the same sunblock that Ironman World Champions Craig Alexander and Mirinda Carfrae use. In today's episode, Nic is back, specifically to talk about how certain types of sunscreen can inhibit body cooling, and how sunscreen can block pores. Nic discusses the formulation called "Scape Sunblock", which is available at http://www.scapelabs.com. You'll get Dr. Marten's formulation sent straight to you. ----------------------------------------------------- Special Announcements: -Click here to donate $1 to keep this podcast going! -BenGreenfieldFitness Inner Circle is now just $1 for a 14 Day Sneak Peek! Click here to join now. - Get insider VIP tips and discounts from Ben - conveniently delivered directly to your phone! Just complete the information below... First Name Last Name Email Cell # (1+area code) --------------------------------------------------------------- Listener Q&A: ====================================== [contact-form 3 "AskBen"] ====================================== Melanie asks: I need advice on how to reduce estrogen dominance. I'm not interested (at least right now) in using a progesterone cream. I'd like to reduce estrogen naturally. Which foods will help reduce and which foods will increase the problem? I avoid soy like the plague and I eat a mostly organic, whole foods diet. I exercise (maybe not enough) and I try to avoid drinking from plastic and avoid parabens in cosmetics. Also, I read that high fat diet should be avoided. Does this apply to healthy fats? I eat lots of fats, but the good ones (love nuts and seeds). Any advice is appreciated since PMS derails my exercise and healthy eating. Joy asks: I'm doing my 1st Sprint Triathlon in July. I own a stationary bike and was wondering if and or what the big difference is between using an indoor trainer or a stationary bike? Was thinking of buying an indoor trainer but didn't know if I should spend the money when I Do own a SB. Chris asks: Do you have any advice for general Achilles health? I've had to modify a lot of the hill training simply because after I do the hills my Achilles will ache. I've also noticed (all the sudden) that at distances greater than 13-14 miles I start getting achilles pain. Suzanne asks: I saw that you were taking Phenocane as a COX2 inhibitor. In your opinion how would you compare this to Saligesic or White Willow stem bark for pain management? And for inflammation comparing Boswellia and Proteolytic enzymes (and of course fish oils -omega 3's)? I know that everyone is different and you have to be willing to be your own test dummy sometimes, but it's helpful to gain insight from others. Also, do you recommend a specific high quality supplement company for Phenocane? Brian asks: I noticed a lot of pre workout supplements have 1,3 dimethylamylamine is this a safe ? I currently take Jack3d with the following ingredients: Arginine Alpha-Ketoglutarate, Creatine Monohydrate, Beta Alanine, Caffeine, 1,3-Dimethylamylamine (Geranium [Stem]), Schizandrol A Rich asks: What are your thoughts on the supplements: Juice Plus & Mona Vie from a general health point of view? I have been taken these two supplements for awhile and as a new listener I am thinking about maybe switching to or at least adding the Living Fuel Supergreens to my diet. Jack asks: I'm 17 years old, and for as long as I can remember I've had very shaky hands. Usually not a big deal, but I'm a competitive rock climber and going into the Army, which both require steady hands. I've been to many doctors with little success. Any diet or supplementation advice that might help? I eat pretty healthy, especially for my age, but my diet still isn't perfect. I've been trying Natural Calm Magnesium for a little while, but no success yet. -------------------------------------------- Remember, if you have any trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com And don't forget to leave the podcast a ranking in iTunes - it only takes 2 minutes of your time and helps grow our healthy community! 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Background: As cell-free circulating DNA exists predominantly as mono-and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant breast diseases. Methods: The concentrations of cell-free DNA and nucleosomes as well as the protease and caspase activities were measured in serum of patients with benign breast disease (n = 20), primary breast cancer (M0, n = 31), metastatic breast cancer (M1, n = 32), and healthy individuals (n = 28) by PicoGreen, Cell Death Detection ELISA, Protease Fluorescent Detection Kit and Caspase-Glo (R) 3/7 Assay, respectively. Results: Patients with benign and malignant tumors had significantly higher levels of circulating nucleic acids in their blood than healthy individuals (p = 0.001, p = 0.0001), whereas these levels could not discriminate between benign and malignant lesions. Our analyses of all serum samples revealed significant correlations of circulating nucleosome with DNA concentrations (p = 0.001), nucleosome concentrations with caspase activities (p = 0.008), and caspase with protease activities (p = 0.0001). High serum levels of protease and caspase activities associated with advanced tumor stages (p = 0.009). Patients with lymph node-positive breast cancer had significantly higher nucleosome levels in their blood than node-negative patients (p = 0.004). The presence of distant metastases associated with a significant increase in serum nucleosome (p = 0.01) and DNA levels (p = 0.04), and protease activities (p = 0.008). Conclusion: Our findings demonstrate that high circulating nucleic acid concentrations in blood are no indicators of a malignant breast tumor. However, the observed changes in apoptosis-related deregulation of proteolytic activities along with the elevated serum levels of nucleosomes and DNA in blood are linked to breast cancer progression.
Regulated intramembrane proteolysis of the amyloid precursor protein (APP) by the protease activities α-, β- and γ-secretase controls the generation of the neurotoxic amyloid β peptide. APLP2, the amyloid precursor-like protein 2, is a homolog of APP, which shows functional overlap with APP, but lacks an amyloid β domain. Compared to APP, less is known about the proteolytic processing of APLP2, in particular in neurons, and the cleavage sites have not yet been determined. APLP2 is cleaved by the β-secretase BACE1 and additionally by an α-secretase activity. The two metalloproteases ADAM10 and ADAM17 have been suggested as candidate APLP2 α-secretases in cell lines. Here, we used RNA interference and found that ADAM10, but not ADAM17, is required for the constitutive α-secretase cleavage of APLP2 in HEK293 and SH-SY5Y cells. Likewise, in primary murine neurons knock-down of ADAM10 suppressed APLP2 α-secretase cleavage. Using mass spectrometry we determined the proteolytic cleavage sites in the APLP2 sequence. ADAM10 was found to cleave APLP2 after arginine 670, whereas BACE1 cleaves after leucine 659. Both cleavage sites are located in close proximity to the membrane. γ-secretase cleavage was found to occur at different peptide bonds between alanine 694 and valine 700, which is close to the N-terminus of the predicted APLP2 transmembrane domain. Determination of the APLP2 cleavage sites enables functional studies of the different APLP2 ectodomain fragments and the production of cleavage-site specific antibodies for APLP2, which may be used for biomarker development.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 12/19
Proteolytic processing of the amyloid precursor protein (APP) by α-secretase prevents the formation of the amyloid β-peptide (Aβ), which is the main constituent of amyloid plaques in brains of Alzheimer's disease (AD) patients. In AD α-Secretase activity is decreased, and overexpression of the α-secretase ADAM10 (a disintegrin and metalloprotease 10) in an AD animal model prevents amyloid pathology. ADAM10 features a 444-nucleotide-long, very GC-rich 5′-untranslated region (5′UTR) with two upstream open reading frames. Because similar properties of 5′UTRs are found in transcripts of many genes, which are regulated by translational control mechanisms, we asked whether ADAM10 expression is translationally controlled by its 5′UTR. Here we demonstrate that the 5′UTR of ADAM10 represses the rate of ADAM10 translation. In the absence of the 5′UTR, we observed a significant increase of ADAM10 protein levels in HEK293 cells, whereas mRNA levels were unchanged. Moreover, the 5′UTR of ADAM10 inhibits translation of a luciferase reporter in an in vitro-transcription/-translation assay. Successive deletion of the first half of the ADAM10 5′UTR revealed a striking increase in ADAM10 protein expression in HEK293 cells, suggesting that this part of the 5′UTR contains inhibitory elements for translation. In contrast, the deletion of the 3'-part of the 5'UTR led to significantly reduced protein levels. Thus, we provide evidence that the 5′UTR of ADAM10 may have an important role for post-transcriptional regulation of ADAM10 expression. Therefore these findings might be of significant importance for future research in Alzheimer's disease and the development of novel therapeutic strategies of this devastating disorder.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06
Mon, 14 Dec 2009 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/11029/ https://edoc.ub.uni-muenchen.de/11029/1/Westendorf_Jens.pdf Westendorf, Jens ddc:570, ddc
Enhanced Video PodcastAired date: 4/28/2008 3:00:00 PM Eastern Time
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Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-secretase. Both proteases compete for APP cleavage, but have opposite effects on A beta generation. At present, little is known about the cellular pathways that control APP alpha- or beta-secretase cleavage and thus A beta generation. To explore the contributory pathways in more detail we have recently employed an expression cloning screen and identified several activators of APP cleavage by alpha- or beta-secretase. Among them were known activators of APP cleavage, for example protein kinase A, and novel activators, such as endophilin and the APP homolog amyloid precursor-like protein 1 (APLP1). Mechanistic analysis revealed that both endophilin and APLP1 reduce the rate of APP endocytosis and strongly increase APP cleavage by alpha-secretase. This review summarizes the results of the expression cloning screen in the context of recent developments in our understanding of the cellular regulation of APP alpha-secretase cleavage. Moreover, it highlights the particular importance of endocytic APP trafficking as a prime modulator of APP shedding. Copyright (c) 2006 S. Karger AG, Basel.
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented by major histocompatibility complex (MHC) class I molecules. Here we demonstrate that treatment of mouse fibroblast cells with 20 U interferon qr (IFN-y) for 3 d induces a change in the proteasome subunit composition and that the B-type subunit LMP2, which is encoded in the MHC class II region, is incorporated into the enzyme complex. This is paralleled by reduction of the homologous 6-subunit. IFN-3' stimulation results in a downregulation of the chymotrypsin-like Suc-LLVY-MCA peptide hydrolyzing activity of 20S proteasomes whereas the trypsin-like activity remains unaffected. When tested as a substrate a synthetic 25-mer polypeptide whose sequence covers the antigenic nonapeptide YPHFMPTNL of the MCMV pp89, 20S proteasomes of IFN-3'-induced cells exhibit altered chymotrypsin-like cleavage site preferences. In the absence of IFN-qr induction, the naturally processed nonamer peptide that is presented by MHC class.I molecules appears as a minor cleavage product. IFN-'y activation does not result in an increase of the final peptide but results in a different set of peptides. We hypothesize that these peptides represent precursor peptides that can be trimmed to final peptide size.
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9435/1/9435.pdf Fritz, Hans; Machleidt, W.; Jochum, Marianne ddc:610, Medizin
Proteolytic degradation of receptor sites on the mitochondrial surface strongly reduces the efficiency of mitochondrial protein import. The remaining residual import still involves basic mechanisms of protein import, including: insertion of precursors into the outer membrane, requirement for ATP and a membrane potential, and translocation through contact sites between both membranes. The import of a chloroplast protein into isolated mitochondria which occurs with a low rate is not inhibited by a protease-pretreatment of mitochondria, indicating that this precursor only follows the bypass pathway. The low efficiency of bypass import suggests that this unspecific import does not disturb the uniqueness of mitochondrial protein composition. We conclude that mitochondrial protein import involves a series of steps in which receptor sites appear to be responsible for the specificity of protein uptake.
Fri, 1 Jan 1988 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9337/1/9337.pdf Kortmann, H.; Jochum, Marianne; Fröhlich, D.; Billing, A.
Sun, 1 Jan 1984 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9228/1/9228.pdf Heidland, August; Jochum, Marianne; Scheidhauer, K.; Schäfer, R. M.; Hörl, W. H. ddc:610, Medizin
Many nuclear-coded mitochondrial proteins are synthesized as larger precursor polypeptides that are proteolytically processed during import into the mitochondrion. This processing appears to be catalyzed by a soluble, metal-dependent protease localized in the mitochondrial matrix. In this report we employ an in vitro system to investigate the role of processing in protein import. Intact Neurospora crassa mitochondria were incubated with radiolabeled precursors in the presence of the chelator o-phenanthroline. Under these conditions, the processing of the precursors of the beta-subunit of F1-ATPase (F1 beta) and subunit 9 of the F0F1-ATPase was strongly inhibited. Protease- mapping studies indicated that import of the precursor proteins into the mitochondria continued in the absence of processing. Upon readdition of divalent metal to the treated mitochondria, the imported precursors were quantitatively converted to their mature forms. This processing of imported precursors occurred in the absence of a mitochondrial membrane potential and was extremely rapid even at 0 degrees C. This suggests that all or part of the polypeptide chain of the imported precursors had been translocated into the matrix location of the processing enzyme. Localization experiments suggested that the precursor to F1 beta is peripherally associated with the mitochondrial membrane while the precursor to subunit 9 appeared to be tightly bound to the membrane. We conclude that proteolytic processing is not necessary for the translocation of precursor proteins across mitochondrial membranes, but rather occurs subsequent to this event. On the basis of these and other results, a hypothetical pathway for the import of F1 beta and subunit 9 is proposed.
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