Podcast appearances and mentions of Steve Huffman

This Week In Startups is made possible by:Plaud https://Plaud.ai/twistPilot https://pilot.com/twistAgree https://agree.comIM8 Health https://IM8health.com/twistAfter watching Elon build out his rocket (and AI) company over the past 20 years, Jason celebrates the SpaceX IPO on a new TWiST. He explains why some investments are evaluated based on earnings and current numbers, while other stocks are bets on expensive visions for the future, and why SpaceX why likely pay off across multiple time horizons.PLUS Polsia solo founder Ben Cera is back with guidance for founders on creating a “Purple Cow”: a unique experience that makes their brand memorable.Guest:Ben Cera on X: https://x.com/BenceraPolsia: https://polsia.com/Polsia on X: https://x.com/polsiaBen on TWiST E2256 (Feb 2026): https://www.youtube.com/watch?v=QCce8e02IswRelevant Links:SpaceX: https://www.spacex.com/SPCX on Yahoo Finance: https://finance.yahoo.com/quote/SPCX/Starlink: https://www.starlink.com/Planet Labs: https://www.planet.com/Palantir: https://www.palantir.com/Valor Equity Partners: https://www.valorep.com/Seth Godin's “Purple Cow” on Amazon: https://www.amazon.com/Purple-Cow-New-Transform-Remarkable/dp/1591843170Uber Ice Cream stunt article: https://finance.yahoo.com/news/ubers-brilliant-marketing-stunt-hail-195946535.htmlHillsborough Flintstones House article: https://www.sfgate.com/travel/article/The-Flintstone-House-is-now-for-rent-on-Airbnb-10420107.php“19 Hours Inside the Airbnb X-Mansion” article: https://www.theringer.com/2024/05/29/pop-culture/x-mansion-airbnb-x-men-icons-experienceWas The Pepsi Challenge based on LIES? https://www.historyoasis.com/post/the-pepsi-challengeCloudKitchens: https://cloudkitchens.com/Cluely: https://cluely.com/Timestamps:0:00 SpaceX IPO details2:12 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!7:21 The voting vs. weighing investment framework9:41 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to https://pilot.com/twist and get $1,200 off your first year.19:53 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life!22:25 The media's SpaceX criticisms and "hot takes"23:54 Ben Cera of Polsia is back26:53 Why Jason says no to a free tier29:10 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.34:27 The wisdom of Seth Godin's "Purple Cow"50:37 The "Pepsi Challenge" model1:05:45 Lon got a dog, Jason got routers1:10:37 The YouTuber to movie theater pipeline1:15:20 Jason's new favorite travel bagSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:NetSuite - Netsuite.com/TWiSTDeel - Deel.com/TWiSTSquarespace - Squarespace.com/TWiSTTwo days before SpaceX launches the largest IPO in history at a flat $135/share, our VC roundtable drops a scorcher: The top 1% of seed deals might actually be underpriced. Plus: the "Sequoia scam" dual-tranche controversy, tokens-for-equity deals, and whether Claude Fable 5 is a true step function.Tomasz Tunguz (Theory Ventures), Michael Downing (Castalia Capital), and Paige Doherty (Behind Genius Ventures) join Alex to go deep on Seed investing, startup economics, AI spend, and the impact of smarter AI on the founder journey.Guest Links:Tomasz Tunguz: https://x.com/ttunguzTheory Ventures: https://theoryvc.com/Michael Downing: https://www.linkedin.com/in/michaeldowning/Castalia Capital: https://castalia.capital/Paige Doherty: https://x.com/paigefinnnBehind Genius Ventures: https://www.behindgeniusventures.comShow Links:Anthropic's IPO announcement: https://www.anthropic.com/news/confidential-draft-s1-secOpenAI's IPO announcement: https://openai.com/index/openai-submits-confidential-s-1/Bending Spoons F-1 filing: https://www.sec.gov/Archives/edgar/data/2004711/000110465926071170/tm2613674-7_f1.htmSpaceX IPO filing: https://www.sec.gov/Archives/edgar/data/1181412/000162828026040364/spaceexplorationtechnologib.htmBrendan Foody's post on Sequoia: https://x.com/BrendanFoody/status/2063470286515683759Claude Fable 5: https://www.anthropic.com/news/claude-fable-5-mythos-5OpenRouter data on Chinese models: https://openrouter.ai/rankings?view=daySaronic: https://www.saronic.com/MotherDuck: https://motherduck.com/Nox Metals: https://noxmetals.co/Timestamps:0:00 Tomasz Tunguz, Michael Downing & Paige Doherty join2:07 The SpaceX IPO and the IPO window4:22 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!6:30 The new bar: 10x growth (not 3x) to raise a great Series A8:46 Net-new AI budgets9:46 Squarespace: Turn your idea into a beautiful website! Go to https://www.squarespace.com/twist for a free trial. When you're ready to launch, use offer code TWIST to save 10% off your first purchase of a website or domain.11:09 How some founders are outgrowing venture capital11:44 The power pendulum swings back to founders12:46 SpaceX vs. OpenAI vs. Anthropic: Which IPO is most enticing?19:53 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.26:07 Tokens-for-equity, GPU-hours-for-equity & the financialization of compute28:35 Founders airing VC dirty laundry (napping VCs included)29:56 Netsuite - The business landscape is very chaotic right now. That's why you need NetSuite, by Oracle. Get the free business guide Demystifying AI at https://Netsuite.com/TWiST36:38 Claude Fable 5 first impressions: pricing, benchmarks & orchestration45:42 Where value accrues: application layer vs. models vs. private data1:00:06 Nationalization of AI labs: Bernie Sanders, Sam Altman & Trump agree?!1:01:25 Portfolio spotlights: Saronic, MotherDuck, and Nox MetalsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanis

The AI Tutor That Makes Kids Actually Think | E2298This Week In Startups is made possible by:Northwest Registered Agent https://northwestregisteredagent.com/twistLinkedIn Jobs https://LinkedIn.com/twistShopify https://shopify.com/twistPlaud https://Plaud.ai/twistToday's show:*Schools teach kids to memorize formulas. AI helps them skip thinking entirely. Brilliant founder Sue Khim joins TWiST to tell us how her new AI tutor, Koji, uses the Socratic Method to help students solve complex problems on their own. Find out why she says “People aren't anti-AI. They're anti-being replaced and anti-slop.”PLUS Jason's take on the VC horror stories going around X… and his own anecdote about the tenacity and passion of legendary investor John Doerr.Guest:Sue Khim on X: https://x.com/suekhimBrilliant: https://brilliant.org/Viral Koji launch video: https://x.com/suekhim/status/2060378988606878147Relevant Links:Viral Greg Isenberg post about VCs: https://x.com/gregisenberg/status/2061794787825479818Travis Kalanick's story: https://x.com/travisk/status/2062224472426365045Matthew Prince's stories: https://x.com/eastdakota/status/2062860530360959273John Doerr on X: https://x.com/johndoerrRoelof Botha on X: https://x.com/roelofbothaMichael Moritz on LinkedIn: https://www.linkedin.com/in/michaelmoritz/Mohr Davidow Ventures: https://mdv.com/Jason's book “Angel: How to Invest in Technology Startups”: https://www.amazon.com/Angel-Invest-Technology-Startups-Timeless-Investor/dp/0062560700Timestamps:0:00 Sue Khim's Alltuition origin story1:41 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!4:10 Brilliant: from launch to product market pull10:46 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist15:08 Pricing against tutors, not apps19:25 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist21:22 Koji demo24:11 Keeping Brilliant local while expanding30:22 Shopify - Turn those What Ifs into sales with the e-commerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist40:10 Every founder has a VC horror story44:33 John Doerr went the extra mile to hear JCal's pitch52:55 The LAUNCH investment strategySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Grasshopper Bank https://grasshopper.bank/twistVanta https://www.vanta.com/twistRender https://render.com/twistPlaud https://Plaud.ai/twistToday's show:Anthropic wrote a blog post calling for a global AI slowdown. Meanwhile, Sen. Bernie Sanders wants the government to seize 50% of every major AI company's stock. Find out why JCal is reconsidering universal basic (or even high!) income policies, and why he thinks the 2028 presidential election will likely come down to AI policies.PLUS a live ComfyUI demo from founder Yoland Yan. Find out why the free-to-use open-source node-based platform has become a crucial part of millions of designers' and VFX experts' workflows, and how their tool has been used to create everything from “The Wizard of Oz” at the Vegas Sphere to those viral Coca-Cola holiday ads.GuestYoland Yan: http://x.com/yoland_yanComfyUI: https://comfy.org/AI Models and ToolsIdeogram 4.0: https://ideogram.ai/models/4.0/Stable Diffusion: https://stability.ai/LTX Video: https://github.com/Lightricks/LTX-VideoLoRa: https://huggingface.co/docs/diffusers/training/loraGoogle Veo: https://deepmind.google/models/veo/Relevant Links:Anthropic: “When AI Builds Itself”: https://www.anthropic.com/institute/recursive-self-improvementBernie Sanders: “The Public Should Own Half of the Big AI Companies”: https://www.sanders.senate.gov/op-eds/the-public-should-own-half-of-the-big-a-i-companies/Bloomberg: “Sam Altman-Backed Group Completes Largest US Study on Basic Income”: https://www.bloomberg.com/news/articles/2024-07-22/ubi-study-backed-by-openai-s-sam-altman-bolsters-support-for-basic-incomeTimestamps:0:00 Guest 1: Yoland Yan, ComfyUI — live demo intro2:06 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!4:34 Guest 1: Yoland Yan, ComfyUI — live demo intro9:47 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.20:05 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist22:24 What is Outpainting?30:01 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.32:13 Jason's insider sales team advice38:42 LA mayoral race: Bass vs. Pratt42:25 Anthropic wants AI to slow down?48:45 Will Sen. Sanders' argument resonate with the public?59:39 Why 2028 will be the AI jobs election1:05:32 Brian Chesky's new AI lab1:15:21 Jason's "Mandalorian and Grogu" review1:18:53 YouTubers take over the box office1:24:16 Dean Potter vs. Alex HonnoldSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Scott gets the latest on the Ohio Medicare fraud scandals from Ohio state Senator Steve Huffman.See omnystudio.com/listener for privacy information.

Scott talks with Ohio state Senator Steve Huffman about the latest in the Medicare scandal. Also Carole Osborne tells you how to tell if your pet has "doggie dementia". Finally Will Greenwald helps you get the most out of your TV.See omnystudio.com/listener for privacy information.

Scott gets the latest on the Ohio Medicare fraud scandals from Ohio state Senator Steve Huffman.See omnystudio.com/listener for privacy information.

Scott talks with Ohio state Senator Steve Huffman about the latest in the Medicare scandal. Also Carole Osborne tells you how to tell if your pet has "doggie dementia". Finally Will Greenwald helps you get the most out of your TV.See omnystudio.com/listener for privacy information.

This Week In Startups is made possible by:Northwest Registered Agent - NorthwestRegistereAagent.com/TWISTEvery - Every.ioSentry - Sentry.io/TWISTToday's show:Want to get to space? Several launch companies can help you. SpaceX, Rocket Lab, the Russians, the list goes on. But what about once you make it upstairs, then what? Impulse Space CEO and CTO Tom Mueller is building the next stage of our orbital economy. With its Mira and Helios spacecraft, we'll soon be able to take mass from lower orbits to higher orbits, or even to the Moon, with ease.Meanwhile, venture capitalists are enamored with the idea of humanoid robots — robots share our shape, our work environment, and even our tools. But startups like Dusty Robotics are taking a different tack; instead of building human-shaped robots, Dusty has built a small, wheeled 'bot that can mark out building sites quickly and accurately. And it's doing more revenue than all humanoid robotics companies combined, I reckon. Dusty's CEO, Dr. Tessa Lau, joins Alex to go deep on purpose-built robots in today's build-crazy market.Timestamps:0:00 Blue Origin, and why fixing things in orbit is hard2:19 What Mira is and what it does4:35 Why was the commercial demand for Mira softer than expected5:20 Space Force demand and the GEO-capable Mira7:08 Helios: a "rocket on top of a rocket."10:10 Sentry - Your team should be focused on shipping features — not chasing down bugs. New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST11:35 How Helios beats Falcon Heavy on price ($25M)13:35 Reusability, in-orbit refueling, and propellant depots15:38 Landers, the Moon base, and "Mega Helios."18:52 NSSL and the politics of flying government payloads20:16 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io20:51 Why the Moon matters: megastructures and data centers in space25:09 The space talent market and the SpaceX "mafia."30:16 Northwest Registered Agent: Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twistSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:Check out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Deel https://deel.com/twistQuo https://quo.com/TWiSTLinkedIn Jobs https://LinkedIn.com/twistToday's show:Cortical Labs is the world's first company selling biological computers. Their CL1 fuses lab-grown human neurons (derived from stem cells, not actual folks) with silicon hardware to create Synthetic Biological Intelligence (SBI).Founder Dr. Hon Weng Chong walks us through how the system works and why neurons are more efficient than GPUs at reinforcement learning. (Also… is this computer alive?)PLUS Pyka co-founder and CEO Michael Norcia explains the various uses for his autonomous aircraft, from crop-spraying drones in Brazil to a a hybrid-electric defense UAV for the military.Guests:Cortical Labs: ****https://corticallabs.com/Dr. Hon Weng Chong on X: https://x.com/dr1337Pyka: https://www.flypyka.com/Pyka on Instagram: https://www.instagram.com/flypyka/?hl=enFurther Reading:2022 Pong paper in Neuron: https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-62017 Paper: “Attention is All You Need”; https://arxiv.org/abs/1706.03762The “Barista Test” for Artificial Intelligence: Chris Rourk: https://medium.com/predict/the-turing-test-is-so-last-century-the-barista-test-for-artificial-general-intelligence-faf91034fa8cNotable Links:Playing “DOOM” on CL1: https://www.youtube.com/watch?v=yRV8fSw6HaEDayOne Data Center: https://dayonedc.com/NeurIPS 2026 Conference: https://neurips.cc/Neuralink: https://neuralink.com/CliniCloud Digital Stethoscope and Thermometer: https://www.design-industry.com.au/clinicloudAir Force Research Laboratory (AFWERX): https://afwerx.com/Joby Aviation: https://www.jobyaviation.com/Prime Movers Lab: https://www.primemoverslab.com/Timestamps:0:00 What is "biological computing"?2:49 Cortical's new $30 million raise4:15 The world's first biological data center9:48 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.10:51 Biological computers have a learning advantage19:43 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST29:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist38:46 From paper airplanes to Group 4 UAVs52:20 Introducing the DropShip defense drone58:28 How regulations block US drones1:00:40 Why Pyka builds everything in-houseSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Grasshopper Bank https://grasshopper.bank/twistLinkedIn Jobs https://LinkedIn.com/twistNorthwest Registered Agent https://northwestregisteredagent.com/twistToday's show:Jason breaks down the real math behind raising a seed round. Here's the funnel: contact 150 firms, get 50 first meetings, convert 2o into second meetings, and close 2 term sheets.PLUS Jason responds to viewer questions about why hardware is no longer a dirty word for investors, how to differentiate your startup from frontier-model companies like OpenAI, even when they're in your niche. Plus a pitch for “Founder Community College,” and anecdotes from Lon's European odyssey.Thanks for the Questions:Richard Corral: CEO of Quanto: https://quanto.co/ØnProtons on X: https://x.com/0nProtonsSergeDawg on X: https://x.com/sergedawgMahika GolaniPeridot: https://www.tryperidot.com/Shawn Sully on X: https://x.com/arooglePrograms and Accelerators Mentioned:Y Combinator: https://www.ycombinator.com/Techstars: https://www.techstars.com/Antler: https://www.antler.co/PearX: https://pear.vc/pearx/Sequoia ARC: https://www.sequoiacap.com/arc/Kauffman Fellows: https://www.kauffmanfellows.org/Companies and Startups Referenced:Whoop: https://www.whoop.com/Knightscope: https://knightscope.com/Eight Sleep: https://www.eightsleep.com/Cafe X: https://www.cafexapp.com/Media Referenced:New Yorker Sam Altman profile: https://www.newyorker.com/magazine/2026/04/13/sam-altman-may-control-our-future-can-he-be-trustedOff-Duty RecommendationsTerra Kaffe Demi compact automatic espresso machine: https://www.terrakaffe.com/products/tk-demiOsteria Pastella (Florence, Italy): https://www.osteriapastella.it/Timestamps:0:00 Inside the TWiST private group chat3:25 How to react when an investor says your "too early."6:50 The ultimate seed round funnel8:48 Jason's new Associate in Training program10:09 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.18:28 How have the metrics for early-stage companies changed?20:20 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist22:34 TWiST Bounties update23:43 Competing against frontier labs30:03 What signals real investor-founder alignment?30:14 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist36:07 A crash course in Bay Area startup culture40:15 Automatons-as-a-Service (AaaS)42:29 Who in Silicon Valley does Jason really not like?49:59 Museum Etiquette with Lon HarrisSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Render - render.com/twistDeel - deel.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistToday's show:The "Ryanair of drone delivery" just raised $50 million and plans to bring its technology from Europe to the United States. Manna founder Bobby Healy explains to TWiST how his Dublin-based company completed 300,000 deliveries while some rivals are still publishing blog posts, and why low-cost airline economics will decide who wins the autonomous skies.Sticking to the drone theme, TWiST welcomed Theseus co-founder Ian Laffey, who called in from Kyiv to tell us about his company's drone guidance system. It runs off a simple camera and Google Maps. The technology could rewrite the modern, GPS-jammed battlefield, and bring more firepower to smaller nations fending off larger foes.Guest Links:Manna https://www.manna.aeroBobby Healy https://www.linkedin.com/in/bhealy/Manna funding announcement https://www.manna.aero/blog/series-bTheseus https://www.theseus.us/Ian Laffey https://www.linkedin.com/in/ilaffey2/Most recent Theseus funding announcement https://techcrunch.com/2025/04/17/defense-tech-theseus-landed-y-combinator-the-us-special-forces-and-4-3m-from-a-tweet/The tweet that kickstarted Theseus: https://x.com/ilaffey2/status/1759353732075294766Timestamps:0:00 Bobby Healy of Manna joins TWiST1:41 How a Manna base works: drones migrate around the city like Waymos7:18 Battle-hardened in Irish weather: 97% uptime in wind and rain8:52 Margin-positive economics & the path to $0.20 per delivery9:25 Northwest Registered Agent: Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist12:32 $50M Series B vs competitors raising $600–800M19:51 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.22:53 The peer-to-peer drone future and hyper-local commerce25:46 Growing from 170 to 570 people and moving manufacturing to Oklahoma28:43 Ian Laffey of Theseus joins TWIST29:57 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.30:58 Inside Ukraine's drone industry: front-line iteration and free-market speed33:55 How GPS gets jammed across the spectrum35:10 Theseus's approach: cameras + satellite maps + ML37:04 The product: Raspberry Pi, SD card, camera — pretending to be GPS49:02 Ukraine: 6–8M drones a year. The US: 300K over two years.51:17 Are US drone primes actually reconstituting the supply chain?58:22 Y Combinator as a defense tech accelerator59:40 "Pick an issue and start working as hard as you can towards it"Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Every.io https://every.ioShopify https://shopify.com/twistRender https://render.com/twistPlaud https://Plaud.ai/twistToday's show:Startups like Divergent Technologies are producing components and aircraft for the military through new systems that are better, faster, and cheaper than conventional methods. CEO and co-founder Lukas Czinger stops by TWiST to share the company's vertically integrated, AI-driven manufacturing platform and how he transitioned from hypercar parts to working directly with the Pentagon on autonomous aircraft.Plus, 50 million Americans are on antidepressants, and it's not necessarily the right treatment for all of them. Outro Health co-founders Brandon Goode and Dr. Mark Horowitz share their hyperbolic tapering method, which helps patients get off drugs like Zoloft and Prozac without suffering through traumatic and potentially dangerous side effects.GuestsLukas Czinger: https://x.com/lukasczingerDivergent Technologies: https://www.divergent3d.comCzinger Vehicles: https://www.czinger.com/Brandon Goode: https://www.linkedin.com/in/goodebrandon/Dr. Mark Horowitz: https://x.com/markhoroOutro Health: https://outro.comTimestamps:0:00 Divergent shifted from hypercar development to 3D printing all kinds of components1:33 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!4:10 How 3D printing has exponentially improved8:18 Making military components faster, better, and cheaper9:58 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io11:00 How Divergent caught the Pentagon's attention19:51 Shopify - Turn those What Ifs into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist25:29 Why Outro Health helps patients taper off SSRIs30:06 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.36:37 Is depression caused by a "chemical imbalance"?46:37 Understanding the hyperbolic tapering method58:32 How Outro makes money1:10:01 Leaked Meta layoff audio1:13:41 Cloudflare CEO drops "measurer" roles1:18:16 CrowdHealth - CrowdHealth lets you ditch the bureaucracy with a peer-to-peer funding platform for your healthcare. Get started for $99 per month for your first three months by using the code TWIST at https://JoinCrowdHealth.com/twist.1:19:17 Why Trump canceled his AI executive order1:28:08 Polymarket sharps on Russia vs. Ukraine, SpaceX ticker symbol1:33:34 Luel vs. Kled update: Is this nepotism at work?1:37:02 Chris Nolan doesn't have a smartphone1:43:04 Jason's favorite new espresso machineSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Grasshopper Bank - https://grasshopper.bank/twistLinkedIn - https://linkedIn.com/twistNorthwest Registered Agent - https://northwestregisteredagent.com/twistPlaud - https://Plaud.ai/twist Why raise $200 million if you are already profitable? That's the question Jason and Alex put to Mercury's founder and CEO, Immad Akhund, after the entrepreneur raised another massive round for his upstart, technology-friendly bank. TWiST then welcomed Kled founder Avi Patel to discuss the startup he considers a clear ripoff of his own company. Jason gavels in verdicts on all parties involved, including Y Combinator and venture capital firm General Catalyst. The show closes with a news lightning round, including OpenAI's decision to offer $2 million in token credits to hundreds of startups.Guest Links:Mercury https://mercury.comMercury funding announcement https://www.businesswire.com/news/home/20260520511817/en/Mercury-Raises-$200-Million-Series-D-at-$5.2B-ValuationImmad Akhund on X https://x.com/immadKled https://www.kled.ai/Avi Patel on X https://x.com/avipat_/Avi's complaint https://x.com/avipat_/status/2055384102409253056General Catalyst https://www.generalcatalyst.com/Y Combinator https://www.ycombinator.com/Delve https://techcrunch.com/2026/04/23/another-customer-of-troubled-startup-delve-suffered-a-big-security-incident/Discussion links:Anthropic's attack on secondary trading https://techcrunch.com/2026/05/12/anthropic-warns-investors-against-secondary-platforms-offering-access-to-its-shares/Vanta https://www.vanta.com/twistTimestamps:0:00 Welcome to This Week in Startups!2:14 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:27 Immad Akhund (Mercury) joins to discuss $200M raise6:33 Mercury's origin story and path to $650M run rate9:53 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist14:23 Stablecoins: where they work, why Mercury won't launch its own20:13 LinkedIn - Thanks to our partners at LinkedIn! Post your job for free at https://linkedIn.com/twist then promote it to get access to LinkedIn Jobs' new AI assistant.22:38 AI agents, and the future of money movement27:30 Why Mercury raised less this round30:11 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.42:48 Avi Patel (Kled) joins to discuss copycat startups57:06 Jason's verdict on YC's hacker culture & "appearance of impropriety"1:17:39 Sam Altman's $2M-in-tokens-for-equity offer to YC founders1:24:32 NYC hotel housekeepers cross $100K in time under new union contract1:30:14 Minimum wage, immigration & the case for raising it slowlySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Vanta - Vanta.com/TWISTSentry - Sentry.io/TWISTDeel - Deel.com/TWISTToday's show:AI is the villain of the 2026 commencement cycle, with business luminaries — including Eric Schmidt — booed for discussing or praising the technology. As students graduate into a job market forcibly reshaped by AI, increasingly negative public polling on the potential impacts of artificial intelligence on society is clearly not missing the mark.Jason and Alex then discussed The Information's reporting that Anthropic and OpenAI earn nearly 90% of all startup AI revenue, a Stanford student's viral essay regarding their time at the university in a post-ChatGPT world, Flock Safety's impressive (and worrying) web of cameras, and the upcoming Mark II AI bookmark. The episode closes with questions from our live audience!TWIST Links:Bounty website https://www.thisweekinstartups.com/bountySidebar bounty challenge https://www.notion.so/launch1/5K-Bounty-Create-Sidebar-App-for-Podcasts-34150ff313d280adbd8ed6204676513cAnnotated.com bounty challenge https://annotated.lovable.app/Timestamps:0:00 TWiST All-Stars summer lineup announcement2:43 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!5:08 Eric Schmidt booed at University of Arizona commencement8:57 Why Gen Z feels "double-crossed" by AI leaders10:10 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.15:22 Is this AI's Vietnam moment? The anti-war parallel18:04 Theo Baker's NYT essay on Stanford's AI cheating culture19:24 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST22:30 Why Jason says everyone should start a company28:59 Anthropic + OpenAI capture 89% of AI startup revenue30:17 Vanta: Get $1000 off your SOC 2 at https://www.vanta.com/twist31:57 Are token sales a duopoly? Negative gross margins debate35:17 Risk of building app-layer startups on top of foundation models38:22 Inside Tracker bounty update: AI sidebar + Annotated.com41:18 Mark II: the $159 AI bookmark Alex wants49:31 Flock Safety solves Austin shooting via Manor PD53:39 DeFlock map and the geography of surveillance in Texas1:03:42 Noti Gang: AI for filing patents1:05:45 Noti Gang: Running AI models locally on Mac StudiosSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:IM8 Health: IM8health.com/TWISTSquarespace: Squarespace.com/TWISTRender - Render.com/TWISTSelf-driving just stopped being a science problem and became an engineering challenge instead. That's the through-line of today's double-header with the CEOs of two of the most important AV companies in the world — Wayve's Alex Kendall and Waabi's Raquel Urtasun. Between them: ~$2B raised in the last six months, Uber as a partner, Nissan and Volvo as OEMs, and a shared bet that end-to-end AI plus world models beats Waymo's city-by-city map-and-pray approach.If you want to understand the state of the self-driving industry beyond recent Waymo announcements, this is the episode for you.Guest Links:Wayve: wayve.ai/Waabi: http://waabi.ai/Alex Kendall https://www.linkedin.com/in/alexgkendall/Raquel Uratsun: https://www.linkedin.com/in/raquel-urtasun-298400139/Company Links:Wayve's GAIA-2 world model: https://wayve.ai/thinking/gaia-2/Wayve's 500 city roadshow: https://wayve.ai/thinking/ai-500-roadshow-500-cities/Wavye's most recent funding round: https://wayve.ai/press/series-d/Waybe + Uber: https://wayve.ai/press/wayve-nissan-uber-robotaxi-collaboration/Waabi closed-loop simulator: https://waabi.ai/insights/waabi-worldWaabi + Volvo: https://waabi.ai/insights/waabi-and-volvo-autonomous-solutions-partner-to-jointly-develop-and-deploy-autonomous-transportation-solutionsWaabi + Uber: https://www.uberfreight.com/en-US/blog/uber-freight-and-waabi-introduce-industry-first-autonomous-truck-deployment-solutionTimestamps:0:00 Alex Kendall (Wayve) joins the show1:19 The contrarian bet on end-to-end AI and world models in 20173:05 What is a world model? GAIA-2 and GAIA-3 explained7:34 Sensor agnosticism: camera, radar, LiDAR and minimum bar for safety9:56 $1.5B raised — have we cracked self-driving?10:09 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.20:38 Squarespace: Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST25:03 How consumers will actually pay: bundle, subscription, or free trial30:15 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.35:59 Raquel Urtasun (Waabi) joins the show36:25 World models as controllable simulators for physical AI43:34 One AI brain across trucks, robotaxis, and beyond47:35 What changed in AI to make 2026 the deployment year52:28 Why Waabi raised $1B when they're capital-efficient58:52 Where Waabi is today: Volvo VNL Autonomous, Dallas-Houston, Uber Freight1:00:50 Per-mile pricing and the Driver-as-a-Service model1:07:20 Has Uber tried to buy Waabi? "Not for sale"Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Pilot -⁠ https://Pilot.com/TWIST⁠Grasshopper Bank -⁠ https://Grasshopper.bank/TWIST⁠Quo -⁠ https://Quo.com/TWiST⁠Plaud - ⁠https://Plaud.ai/twist⁠Anthropic just declared every unauthorized secondary sale of its stock "void" — naming Hiive, Forge, Sydecar, Upmarket, and others in a public hit list. Jason and Alex sit down with Jenny Fielding (Everywhere Ventures), Dave McClure (Practical VC), and Sam Lessin (Slow Ventures) to unpack what the AI lab's move to limit secondary trades means for SPV operators, brokers, and the founders trying to keep control of their cap tables. Plus: a real story of a founder who returned a $15M Series A six months after closing because Claude was going to eat his startup, SaaS moats, and just what does it mean to be rich?Timestamps:0:00 Guest introductions0:48 Anthropic voids unauthorized SPV trades8:41 Accredited investor reform & the SEC sophisticated investor test8:58 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST11:43 Naval's USVC closed-end fund as a workaround16:41 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!17:48 Pro-rata rights battles: when Series A investors push seed investors out19:36 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.29:13 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to https://pilot.com/twist and get $1,200 off your first year.30:23 Storing wealth in stories vs. cash flows34:19 Cerebras and Fervo Energy IPOs — meaningful liquidity?37:54 Will SpaceX, Anthropic, OpenAI IPOs redistribute capital or compound it?45:58 The $15M Series A founder who returned the money because of Claude50:01 Should founders pivot or return capital when the world changes?56:43 OpenAI's $6.6B tender and Shruti Gandhi's viral SF cost-of-living tweet1:00:25 Intercom rebrands to Fin: the AI-first late-stage pivotSubscribe to the TWiST500 newsletter:⁠ https://ticker.thisweekinstartups.com⁠Check out the TWIST500:⁠ https://www.twist500.com⁠Subscribe to This Week in Startups on Apple:⁠ https://rb.gy/v19fcp⁠Follow Lon:X:⁠ https://x.com/lons⁠Follow Alex:X:⁠ https://x.com/alex⁠LinkedIn:⁠ ⁠https://www.linkedin.com/in/alexwilhelm⁠Follow Jason:X:⁠ https://twitter.com/Jason⁠LinkedIn:⁠ https://www.linkedin.com/in/jasoncalacanis⁠Check out all our partner offers:⁠ https://partners.launch.co/⁠Great TWIST interviews:⁠ Will Guidara,⁠⁠ Eoghan McCabe⁠,⁠ Steve Huffman⁠,⁠ Brian Chesky⁠,⁠ Bob Moesta,⁠⁠ Aaron Levie⁠,⁠ Sophia Amoruso⁠,⁠ Reid Hoffman⁠,⁠ Frank Slootman⁠,⁠ Billy McFarland⁠Check out Jason's suite of newsletters:⁠ https://substack.com/@calacanis⁠Follow TWiST:Twitter:⁠ https://twitter.com/TWiStartups⁠YouTube:⁠ https://www.youtube.com/thisweekin⁠Instagram:⁠ https://www.instagram.com/thisweekinstartups⁠TikTok:⁠ https://www.tiktok.com/@thisweekinstartups⁠Substack:⁠ https://twistartups.substack.com⁠

Today's show:Cerebras just jacked its IPO range to $150–$160 a share, OpenAI bought a consulting firm to seed its $4 billion private-equity joint venture, and a startup in Oakland is electrolyzing magnesium out of seawater for one-third the going price. Alex Wilhelm and Jason Calacanis go deep with AI21 co-CEO Ori Goshen on why model orchestration, not bigger LLMs, will decide who wins enterprise AI.The crew also covered the decline of OpenClaw, TikTok's new £3.99 ad-free tier, more entries in the live-show sidebar bounty, and had time for a little Off Duty before signing off.Guest Links:Ori Goshen on LinkedInAI21Alex Grant on LinkedInMagrathea MetalsTimestamps:0:00 Ori Goshen, CEO of AI21 joins the show1:20 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!5:14 Why enterprises care about token cost optimization6:01 Jamba as open-weight; Maestro as proprietary orchestration10:08 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist12:56 AI21 customer roster: FNAC, US tech giants, Israeli companies19:01 Alex Grant, CEO of Magrathea Metals joins to discuss pulling magnesium from seawater20:03 Live video of the Oakland pilot electrolyzer20:10 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.22:01 Magnesium as a "gateway metal" for aluminum, defense, aerospace23:20 TETRA joint venture & the Evergreen Project in Arkansas23:38 Series A close, JV economics: $3,000/ton vs. $7,000/ton market29:10 Sidebar bounty update: Glass Sidebar (Oliver Choy) demo30:47 Netsuite - Get the free business guide Demystifying AI at https://netsuite.com/twist31:47 Sidebar bounty update: Sidecast (Patrick Hughes) demo36:09 Reducing scope to "real-time fact checker only" for final round37:24 Ro.co: Ro's insurance checker will let you know if your coverage includes GLP-1s for FREE. Go to https://Ro.co/Twist for your free insurance check.39:07 Cerebras IPO: $115–$125 → $150–$160 per share44:19 Will OpenAI's compute commitments to Cerebras actually get funded?49:19 Fervo Energy IPO — venture-backed geothermal company going public49:40 OpenAI Deployment Company + Tomoro acquisition explained53:51 Anthropic's parallel $1.5B PE joint venture with Blackstone & Goldman56:05 Why Jason thinks these PE spinouts are convoluted financial engineering56:40 OpenClaw's decline + competition from Cowork, Perplexity, Grok1:04:22 TikTok's £3.99 ad-free subscription launches in the UK1:09:09 Knicks sweep 76ers — Jason's playoff predictions1:11:24 Off-duty: "There Is No Antimemetics Division" by qntm1:13:25 Off-duty: Fall of Civilizations podcast by Paul Cooper1:16:37 States' rights, federalism, housing supply & closing thoughtsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:IM8 Health - https://IM8health.com/TWISTEvery - Every.ioSentry - https://Sentry.io/TWISTBanks don't want to hand over their data to AI labs. So David Moscatelli built a $250,000 box that runs AI on-prem. He already has 1,600 pre-orders. On today's episode of TWiST, Jason and Alex sit down with the Go Abacus founder and Yanez's Jose Caldera to unpack how regulated industries are getting AI without the cloud, why Bittensor subnet 54 is incentivizing miners to attack identity systems, and why Cloudflare just laid off 20% of its workforce in the same week it raised guidance. The show closes with Jason explaining what it means to build an AI-first startup, and how workers can derisk their future employment!Guest Links:Go AbacusGo1 direct linkDavid Moscatelli on LinkedInYanezBittensor Subnet 54 on TAOstatsJose Caldera on LinkedInLAUNCH Links:Founder UniversityFounder University Japan application portalNews Links:Cloudflare lays off 20% of its staffCoinbase cuts 14% of its staffBlock post on how it is rebuilding its companyBlock's earnings, including its raised guidanceAnthropic's massive upcoming funding roundWHOOP's new on-demand cliniciansStripe Atlas's growthTimestamps:0:00 Introduction: Jason in Brooklyn, Knicks playoffs2:30 Go Abacus joins: AI infrastructure for regulated industries3:25 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!4:00 The Go1: 2,000-user on-prem AI appliance7:04 Pricing the Go1: How far does $250,000 go?7:24 1,600 orders and the hardware delivery challenge10:14 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST20:23 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io27:22 Chicago tech scene and in-office culture30:09 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.35:11 Yanez joins: How to prove personhood and uniqueness38:32 How biometric capture and bio-keys work40:05 Agent delegation: proving humans authorized AI agents44:19 Bittensor Subnet 54 and incentivizing adversarial miners47:11 Founder University Japan Cohort 2 applications open49:15 Tech layoffs: Cloudflare cuts 20%, Coinbase cuts 14%, Block raises guidance1:02:14 Anthropic's $50B round at $900B pre-money1:04:22 WHOOP adds on-demand clinicians1:06:42 Federalism, state-level regulation, and AI policySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Grasshopper Bank - https://grasshopper.bank/twistPaperOS - https://paperos.com/twistLinkedIn Jobs - https://linkedIn.com/twistPlaud - https://Plaud.ai/twistThe top 5 U.S. venture firms captured 73% of all LP commits in Q1, and three veteran VCs say the math may have officially broken. Aleph's Michael Eisenberg argues we may be witnessing the end of a 60-year run for venture capital as a craft business. Maniv's Mike Granoff and Oxcart's Larry Covert push back, arguing it's merely splitting into two asset classes: "Consensus VC" and traditional VC. Either way, the implications for founders, LPs, and the next decade of innovation are enormous.TWiST is back on the beat with a venture round table discussing investment concentration, the IPO drought, "bullshit ARR" in the AI era, AI gross margins, the U.S.-China chip war, the Iran conflict's impact on defense tech, the death of NATO and the rise of allied supply chains, why Tel Aviv's stock exchange could become the next NASDAQ, and a lightning round on each VC's favorite portfolio company. Let's go!Timestamps:0:00 Intro + sponsor reads (Grasshopper Bank, PaperOS, LinkedIn Jobs)0:58 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!2:13 Introductions: Eisenberg (Aleph), Granoff (Maniv), Covert (Oxcart)3:57 The impact of rising venture capital concentration6:43 "We may be witnessing the end of venture capital"9:17 Consensus VC vs. Traditional VC10:01 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist11:48 Why mid-size firms beat the behemoths on founder access19:35 Coining "Consensus Colossal Collaborative Capital" (CCCC)20:03 AngelList's USVC retail VC fund — does it help mid-size funds?20:18 PaperOS - Whether you're raising a round, launching a fund, or managing a venture portfolio, PaperOS can unlock simplicity and scale across your empire of capital, contracts, and companies. Claim your $10,000 credit at https://paperos.com/twist23:27 Are there more breakout startups today than 5 years ago?28:36 The "bullshit ARR" problem and AI gross margins30:03 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.32:08 Cursor's negative gross margins and the hyperscaler funding flywheel33:06 Are we all electron constrained?35:35 Are we headed for surge pricing on compute?40:22 Will anything replace NVIDIA? NextSilicon, Hailo & Israel's chip stack43:33 Distillation, small models, and Apple's edge advantage46:38 Public trust in AI: should government mandate Waymo & FSD?1:02:58 Defense tech: Saronic, Anduril & the coming defense M&A wave1:06:35 The Iran war timeline & supply chain impact1:18:52 Lightning round: Jiga, Divergent, Volaback, Firehawk, HarbingerSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Render - render.com/twistVanta - vanta.com/twistNorthwest Registered Agent - northwestregisteredagent.com/twistHave you wanted to invest in venture capital alongside your 401k contributions, but struggled to find a way to place a bet? Search no more, for the AngelList team has created USVC, a new fund that will accept investments of as little as $500 from folks who lack accreditation. USVC's Ankur Napgal swung by the show to chat about investment strategies, access, fees, and just how illiquid the venture-like vehicle will prove to be.Jason and Alex were then joined by Jon Durbin, core contributor at Chutes, and Yash Goenka, co-founder and CEO of Humwork. Chutes is the most valuable Bittensor subnet, focused on aggregating GPUs to offer trustless AI compute. Humwork wants to help bring a human into your agentic workflow to unstick your agent when it runs into a hitch. The show closes with a news lightning round — enjoy!Timestamps:0:00 Intro + Plaud AI sponsor read (Jason demos the NotePin S)2:06 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:50 Episode overview: USVC, Chutes, Humwork7:41 USVC structure: $500 min, no accreditation, quarterly redemptions10:28 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist11:39 Fee structure breakdown: 1% mgmt fee, ~2.5% net expense ratio15:41 USVC portfolio: xAI, Anthropic, OpenAI, Crusoe, Vercel16:17 Strategy: 1/3 emerging managers, 1/3 growth, 1/3 secondaries19:00 $1B cap and path to expanding the fund20:33 Vanta - Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 reports fast. Get $1,000 off for a limited time at https://www.vanta.com/twist28:00 What is sovereign compute? Permissionless GPU networks explained30:10 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.44:53 Usage history: 160B tokens/day peak, free-to-paid transition46:41 GPU pricing: from $0.77/hr to $3.50/hr as shortage bites49:13 DeepSeek censorship demo: Taiwan test on DeepSeek chat57:27 Permissionless supply curves: Uber/Airbnb analogy for induced demand59:20 Yash Goenka, co-founder of Humwork (YC S26)1:00:49 Lightning Round: Ryan Cohen wants to buy eBay — Jason's hot take1:12:36 Lightning Round: Cerebras IPO update ($27–36B valuation range)1:14:05 Lightning Round: Spirit Airlines / JetBlue / M&A regulation debate1:19:10 OFF-DUTY: Star Wars: Maul - Shadow Lord1:32:57 Alex's OFF-DUTY: Captain of IndustrySubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Pilot - https://pilot.com/twistShopify - https://shopify.com/twistGrasshopper Bank - https://grasshopper.bank/twistToday's show:An AI agent named Valerie is running a real vending machine in San Francisco — setting prices, ordering inventory, managing a bank account, and posting to Instagram. And it's not just a stunt. We're getting an early look at the future of one-agent companies. There's still work to do to help agents ease into the economy, potentially opening up new startup opportunities.Jason Calacanis and Alex Wilhelm cover a stacked docket: Christian van der Henst demos the Valerie AI vending machine powered by OpenClaw; Robert Myers, CEO of Manifold Labs, breaks down Targon, a confidential GPU compute marketplace running on Bittensor Subnet 4; Jason calls Bitcoin "played out;" Alex is impressed by Anthropic's stunning $900 billion upcoming valuation; and the guys discuss Big Tech's accelerating CapEx spend, Chinese AI models in Congress crosshairs, and the NBA Playoffs.Timestamps:0:00 Intro & sponsor reads (Pilot, Shopify, Grasshopper Bank)1:06 Christian van der Henst: Valerie the AI vending machine demo4:28 Legal structure: Giving an AI agent business ownership via trust7:23 Where agents can and can't operate today10:10 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.11:48 AI café in Stockholm running on agents18:21 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!19:05 Robert Myers, Manifold Labs: Targon & Bittensor Subnet 4 interview20:21 What is Bittensor? An "incubator with 128 subnets"21:08 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist25:21 Pricing, utilization caps, and why GPUs are sold out26:38 Who's using Targon? Customers, use cases, and the mom-and-pop data center argument30:06 Pilot: Focus on your product, let Pilot handle your bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. Head to https://pilot.com/twist and get $1,200 off your first year.35:07 Jason explains the annotated.com vision — 15 years in the making39:11 Polymarket: Will Anthropic flip Bitcoin by Dec 31?40:29 Jason's Bitcoin bear case: "It's played out. No incremental buyers."46:05 MicroStrategy / Strategy updates52:37 AI compute demand vs. the fiber overbuild analogy55:55 Congress pressuring startups over Chinese AI models (DeepSeek, Moonshot)57:11 A16z on the geopolitical risk of Chinese AI models1:00:08 Reflection AI — America's open source AI champion (or lack thereof)1:01:26 Off Duty: Knicks blow out Atlanta Hawks 140–89, Jason goes road-trippingSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

The TWiST AI Basics series is made possible by Google Cloud!Check out Google Cloud's new report, “Future of AI: Perspectives on generative media for startups,” Featuring thoughts from today's guest, Joaquín Cuenca AbelaVisit: goo.gle/futureofgenmedia to check it out!Today's show:In today's edition of TWiST AI Basics, J-Cal is joined by Joaquin Cuenca Abela, co-founder and CEO of Magnific (formerly known as Freepik). We're discussing how generative AI is transforming the creative landscape for startups.In watching today's show you'll have-consider your expectations of what AI video can actually do for you and your business. What used to take a high end production team months and tens of thousands of dollars now takes 24 hours and one person with patience to learn the right tools. This conversation explores how founders can use these tools to scale their creative output better, cheaper, and faster.Timestamps:0:00 Google Cloud - Check out Google Cloud's new report, "Future of AI: Perspectives on generative media for startups," Featuring thoughts from today's guest, Joaquín Cuenca Abela at https://goo.gle/futureofgenmedia1:10 Welcome to AI Basics, presented by Google Cloud!2:11 Meet Joaquín Cuenca Abela, CEO of Magnific (formerly Freepik)3:12 Building a post-apocalyptic SF ad for TWiST in 24 hours4:25 Storyboarding characters, blending images, and text-prompting scenes6:39 The finished product: post-apocalyptic Jason!7:56 How much cheaper is this than traditional advertising?9:34 The tech stack: Magnific's upscaler and 3rd party frontier models11:02 Which Hollywood productions are actually using AI?13:14 Hollywood's 180 from "F these tools" to enthusiastic adoption14:38 One director's 600-person AI-enabled production15:23 Why Magnific built in Málaga, Spain and how they recruit AI talent16:40 Can AI ever match human creative vision?18:43 The future: 100 versions of the same ad, hyper-localized by city21:35 Where to find Magnific + Google Cloud's Future of AI reportConnect with Joaquín and Magnific!Magnific (formerly Freepik) — Joaquín's AI creative platform, 150M+ MAU, $230M ARR → https://magnific.comJoaquín Cuenca Abela on X → https://x.com/cuencaJoaquín Cuenca Abela on LinkedIn → https://www.linkedin.com/in/joaquin-cuenca-abela-905717a/Magnific on X → https://x.com/magnificPanoramio — Joaquín's prior startup, acquired by Google in 2007 → https://en.wikipedia.org/wiki/PanoramioFortune feature on Magnific's $230M ARR rebrand (April 2026) → https://fortune.com/2026/04/28/freepik-magnific-joaquin-cuenca-abela-230-million-arr-video-generation-ai-pivot/Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partner!Google Cloud - Check out Google Cloud's new report, “Future of AI: Perspectives on generative media for startups,” Featuring thoughts from today's guest, Joaquín Cuenca Abela at goo.gle/futureofgenmediaCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:IM8 Health - IM8health.com/twistSentry - Sentry.io/twistDeel - Deel.com/twistPlaud - https://Plaud.ai/twistWhat's the technology story of the year? No, it's not Anthropic's Mythos model, nor any other AI model. Upcoming IPOs? Wrong again. Jason thinks it's China's government's decision to block Meta's acquisition of Manus. The multi-billion-dollar deal was heralded as evidence that AI companies founded in China could sidestep onerous government meddling by moving their operations to Singapore. That loophole now appears closed.Jason and Lon then dug into the newly-reforged OpenAI-Microsoft partnership. The two companies have had a mutually beneficial, if fractious, operating relationship to date; that they had to rework their agreement is not a shock.Then, your hosts watched and digested a video from China purportedly showing a self-driving car hitting a child at speed. What would happen in the United States if such a tragedy struck? And is that fait accompli?Closing the show, Jason and Lon reacted to the latest Russell Brand implosion, discussed Lon's new favorite show ‘Criminal Record,' and shared recommended foot pedals (for AI dictation) and headphones for the road warriors tuning in.Key Links: OpenAI and MicrosoftOpenAI's announcement of its new Microsoft dealMicrosoft's announcement of its new OpenAI dealOpenAI announces its deal with AWSNews that Microsoft was considering legal action against OpenAIMicrosoft-OpenAI negotiations late 2025 edition, and terms announced in early 2026Amazon announces that OpenAI models are coming to AWSTimestamps:0:00 Show starts1:24 OpenAI and Microsoft have a new deal3:22 Why would Microsoft cede exclusive access to OpenAI models?5:36 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!8:09 Why Jason thinks Microsoft and Apple should work together on AI9:45 China will block the Meta-Manus deal12:12 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.12:23 Golden Shares and what they provide14:57 How do you unravel a multi-billion-dollar deal?22:08 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST24:42 The Huawei ADC crash29:49 What happens when something similar happens in the United States?31:55 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.36:15 Russell Brand's public humiliation41:22 Don't trust palm reading!43:59 Lon's Off Duty streaming pick: Criminal Record46:25 Jason's Pick: Which foot pedal for AI dictation is right for you?48:43 Jason's Pick: In the market for new headphones?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Northwest Registered Agent - https://northwestregisteredagent.com/twist LinkedIn Jobs - https://LinkedIn.com/twistToday's show:It's a News and Off-Duty weekend roundup!AngelList's USVC fund is open to anyone with $500, but it's getting pushback on social media. Do the critics have a point?A Special Forces soldier made $409K betting on the military's capture of Venezuelan leader Nicolas Maduro. Is the world just a big casino now?And a NYT podcast defends shoplifting and explores “social murder.” Find out why Jason says they crossed the line.Plus: Why you should teach your kids about investment and more, Off-Duty streaming and book recommendations.Related LinksUSVC: https://usvc.com/AngelList: https://www.angellist.com/Naval Ravikant on X: https://x.com/naval“Don't Listen to the Peanut Gallery; USVC is a Watershed Moment” by Hari Raghavan: https://x.com/haridigresses/status/2047503944839016681@Covered_Call USVC tweet: https://x.com/covered_call/status/2047020060900733306Forge Global: https://forgeglobal.com/Calm: https://www.calm.com/Full DOJ indictment of Gannon Ken Van Dyke: https://www.justice.gov/opa/pr/us-soldier-charged-using-classified-information-profit-prediction-market-betsNYT “The Opinions” podcast: “The Rich Don't Play by the Rules. So Why Should I?” https://www.nytimes.com/video/opinion/100000010849055/the-rich-dont-play-by-the-rules-so-why-should-i.htmlHasn Piker on Twitch: https://www.twitch.tv/hasanabiNew Yorker: Jia Tolentino: https://www.newyorker.com/contributors/jia-tolentinoNYT: Nadja Spiegelman: https://www.nytimes.com/by/nadja-spiegelmanJia Tolentino on X: https://x.com/jiatolentinoGarry Kasparov on X: https://x.com/kasparov63Prof G Media: https://www.profgmedia.com/Kids Investment Club: https://www.kidsinvestmentclub.com/Time stamps:0:00 Intro1:18 Naval's $500 VC Fund Explained5:54 Should You Trust Critics With 2K Followers?7:21 Learn By Betting — Jason's Philosophy10:10 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist12:30 The Maduro Polymarket Scandal13:28 Should the Military Bet on Missions?19:55 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist29:32 NYT Defends Theft & "Social Murder"30:28 There Is No Moral Equivalence33:41 The Nepo Baby Behind the Article35:42 Prof G's "Resist & Unsubscribe" Movement37:54 Walk The Walk — Hasan, Bernie & Performative Outrage44:49 Teaching Kids About Money48:21 The Rich Get Richer & The Poor Stay PoorOff Duty Recommendations“The Complete Maus” by Art Spiegelman: https://www.amazon.com/Complete-Maus-Art-Spiegelman/dp/0679406417“Thinking in Bets” by Annie Duke: https://www.amazon.com/Thinking-Bets-Making-Smarter-Decisions/dp/0735216355“Queen of Chess” trailer: https://www.youtube.com/watch?v=8pmJgtLKBXgGreenlight app: https://greenlight.com/Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisvCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Northwest Registered Agent - https://northwestregisteredagent.com/twist Render - https://render.com/twist Agree - https://agree.com Ro - https://Ro.co/Twist Plaud - https://Plaud.ai/twistToday's show:The US military is running low on missiles, but now, Firehawk Aerospace is using 3D-printed solid rocket propellant to cut production costs in half and 5x U.S. output.Plus: PhD researcher Maruchi Kim just built camera-equipped earbuds that perform on par with Ray-Ban Meta smart glasses and could be the next wearable AI platform hiding in plain sight.GuestsWill Edwards: https://x.com/williewocketsFirehawk Aerospace: https://firehawkdefense.com/Maruchi Kim: https://x.com/maruchikimVueBuds project: https://vuebuds.cs.washington.edu/Related LinksThis Week in AI: https://www.thisweekinai.ai/“Ghost Murmur: The Heartbeat-Tracking Tech That Has Experts Questioning the Laws of Physics”: https://www.military.com/feature/2026/04/18/ghost-murmur-heartbeat-tracking-tech-has-experts-questioning-laws-of-physics.htmlNeurometric: https://www.neurometric.ai/Meta Ray-Bans: https://www.meta.com/ai-glasses/Hanwha Defense USA: https://www.hanwhadefenseusa.com/Raytheon: https://www.rtx.com/Pilatus PC-24 corporate jet: https://www.pilatus-aircraft.com/en/pc-24PlaneSense: https://www.planesense.com/Slopes app: https://slopesapp.com/Speechify: https://speechify.com/Electronic Frontier Foundation: https://www.eff.org/Timestamps:0:00 Are all these layoffs really AI's fault?8:51 Why laid off people should start their own companies9:27 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist13:18 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!15:25 Will Edwards of Firehawk joins the show15:46 What are Solid Rocket Motors (SRMs)?20:06 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.23:10 Who are Firehawk's customers?24:25 Reimagining and reinventing the US military28:35 How do missiles fit into the military's operations?29:34 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life!31:01 What's next on the roadmap for Firehawk?31:49 How to make propellant (with easy to find ingredients)33:13 A cheaper way to fly private38:03 Ro.co: Ro's insurance checker will let you know if your coverage includes GLP-1s for FREE. Go to https://Ro.co/Twist for your free insurance check.40:48 Maruchi Kim of Vuebuds joins the show!44:35 Why are VueBuds better than meta glasses?46:23 The biggest VueBud use cases48:09 Jason wants to use VueBuds on the slopes55:38 Jason's advice for angel investors: never underestimate anyone!Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by:LinkedIn Jobs - linkedIn.com/twistGrasshopper Bank - grasshopper.bank/twistNotion - notion.comToday's show:This week, SpaceX announced that it was partnering with AI coding startup Cursor on new AI models. xAI's parent company is bringing compute, while Cursor brings developer market share and recent successes, training its own coding models.The deal, while interesting, comes with a steep price tag. SpaceX will pay Cursor $10 billion for their shared work, with an option to buy the entire company for $60 billion later this year.After poking our way through the deal, Chris Zacharia and Brian McRindle of Bitstarter joined Lon and Alex. Bitstarter is a ‘Kickstarter for Bittensor,' helping founders get their subnet up and running without tripping over their shoelaces. The Bitstarter crew also broke some news on the show, telling TWIST that they have a new accelerator-ish program kicking off.Next, Ning Ren from Trajectory RL joined the program to explain how Bittensor subnet 11 is using decentralized competitions to design and release better skills. Skills — markdown files with words — have become a critical building tool in the agentic era; how Trajectory will monetize is an open, interesting question.Timestamps:2:27 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!4:07 SpaceX/ xAI "partners" with Cursor!9:35 Will the Cursor deal help pump a future SpaceX IPO?9:57 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.12:14 How AI coding models like Cursor help xAI grow recursively.17:24 Chris Zacharia and Brian McRindle of Bitstarter join the show.20:23 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.29:59 Notion - Notion brings all your notes, docs, and projects into one connected space that just works with AI built right in. Try Notion, with Notion Agent, at https://www.notion.com/twist33:03 How Bittensor subnets monetize and how it compares to VC funds.37:04 Is Bittensor hard-capped at 128 subnets?42:37 Bittensor's biggest weakness.46:10 Ning Ren of TrajectoryRL joins the show.47:34 Skills now need entire agents just to write them!48:26 Back up… What are skills?1:07:38 Amazon and Anthropic's 5 BILLION deal1:08:48 Google has 2 new chips!1:09:50 Apple CEO, Tim is COOKED! John Ternus is in!1:11:37 Alex is bullish on MacBook Neo!Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Quo - https://quo.com/TWiST Vanta - https://vanta.com/twist Pilot - https://pilot.com/twist Plaud - https://Plaud.ai/twistToday's show:*Eragon CEO Josh Sirota believes that you should “own your intelligence.” He demos a live enterprise AI operating system connecting email, Slack, calendar, and financial data into a single agentic layer that's pre-trained to understand any business inside and out.PLUS we've got IONA Drones founder Etienne Louvet, a first look at Moonshot's Kimi K2.6, and a brand new Off Duty with JCal and Lon.FULL SHOW NOTES ON NOTION: https://thisweekinstartups-docket.notion.site/TWiST-2278-SHOW-NOTES-34872ca918e380bd9c71e684ce2db7c9?source=copy_linkGuests :Eragon: https://eragon.aiJosh Sirota on X: https://x.com/joshua_sirotaIONA: https://ionadrones.com/Etienne Louvet on X: https://x.com/etienneldvaRelevant LinksEragon Seed Round coverage: https://techcrunch.com/2026/03/18/this-startup-wants-to-make-enterprise-software-look-more-like-a-prompt/Neurometric: https://www.neurometric.ai/Ollama model: https://ollama.com/Orange Slice: https://www.orangeslice.ai/Corgi Insurance: https://www.corgi.insure/Slash Financial: https://www.slash.com/The Syndicate: https://thesyndicate.com/FAA Part 108 Explained: https://pilotinstitute.com/part-108-explained/Zipline: https://www.zipline.com/Google Wing: https://wing.com/Joby Aviation: https://www.jobyaviation.com/Enterprise Ireland: https://www.enterprise-ireland.com/Éire Composites: https://www.eirecomposites.com/Kimi K2.6 blog post: https://www.kimi.com/blog/kimi-k2-6Kimi K2 series on GitHub: https://github.com/moonshotai/Kimi-K2NVIDIA GB300 NVL72 work station: https://www.nvidia.com/en-us/data-center/gb300-nvl72/Timestamps:0:00 Josh from Eragon AI joins the show2:01 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!5:07 Why founders should own and control their data sets8:33 What is a "company world model?"9:48 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST11:32 Eragon demo15:55 Giving agents their own bank accounts19:07 Inside Eragon's first partnerships20:14 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist25:50 How does Eragon make money?29:11 Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.39:33 Etienne Louvet of Iona Drones joins the show42:37 What is FAA's Part 108?47:13 How innovation in drones impacts the aviation industry50:26 Working with Enterprise Ireland58:28 Jason attended the Breakthrough Awards1:04:10 Doug Liman's AI-powered "Bitcoin" movie1:09:09 "Love Story" on FX and "Dust Bunny" on HBO Max1:13:10 Jason's love of tinned fishSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:IM8 Health - https://IM8health.com/twist Grasshopper Bank - https://grasshopper.bank/twist Northwest Registered Agent - https://northwestregisteredagent.com/twist Plaud - https://Plaud.ai/twistToday's show:Is 3D printing the key to not just solving the housing crisis but bringing us all into a more beautiful and utopian future? ICON founder Jason Ballard thinks so. His company is already building homes for the unhoused and delivering barracks to Fort Bliss at half the cost and a fraction of the time. On TWiST, he tells us space construction is also on the agenda.Explore the potential for robot-powered concrete construction can help build cheap homes for the unhoused, modernize our military infrastructure, AND colonize the solar system in this exclusive interview.Then Seby Rubino of Resi Labs demos his real estate “Oracle,” which can guess the price of any home with 98% accuracy… for just fractions of a penny.PLUS Jason tells a story of the rare founder who got one over on him, and why he's moving away from vengeance and anger and into love and acceptable.AND we've got more JCal and Lon recommendations in a brand-new Off Duty.Guests :Jason Ballard: https://x.com/JasonDBallardICON: https://www.iconbuild.com/ICON on X: https://x.com/ICON3DTechSeby Rubino: https://x.com/SebyverseResi Labs: https://portal.resilabs.ai/Timestamps:0:00 Intro + "balance the ledger" tease1:10 Jason Ballard (ICON) joins — 3D-printed homes + defense (ICON Prime)5:18 Housing basics: commutes, quality of life, "food/water/shelter"7:15 ICON Prime: military construction, survivability, speed, supply chain10:08 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.11:35 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!12:43 Fort Bliss barracks: 10 in 6 months, half the cost; blast/ballistics20:23 Beautiful + dignified housing: Community First Village; "where's the floor?"20:29 Grasshopper Bank: Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.30:10 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist37:27 Audience Q&A: longevity/cracking; plumbing + electrical41:33 ICON Titan printer + channel partners; hiring pitch45:47 Sebi Rubino (Rezzy Labs) joins — BitTensor subnet 46 real estate pricing51:18 Tau/BitTensor explained: subnet competitions, "narrow intelligence"59:15 Rezzy demo: portal + pricing engine; customers + business model1:07:49 "Got shivved for 500k" story: acquisition, investors get zero1:20:36 Bounties: annotated.com + AI sidebar + headless CMS on BitTensor1:31:10 Off-duty: View Buds (camera earbuds) + use cases1:38:13 Off-duty: Anker charger/cable/battery "trio"1:41:12 Off-duty: The Audacity (AMC) quick review1:46:43 Wrap-up + secret TWiST group chat on XSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by:LinkedIn Jobs - LinkedIn.com/twist Every.io - every.io Render - render.com/twistToday's show:*Imagine scrolling through mobile games the way your flip through your TikTok feed. What if you could build your own game in 90 seconds and share it with the world? That's what over 100,000 users are enjoying right now on Nanogram.On TWiST, we meet the co-founders: 22-year-old CEO Albert Brotherton and 24-year-old CTO Boris Radilov. They demo the app for us on the air, and Jason immediately spies the potential. Power users are playing 25+ games per session already.We're digging into the co-founders future plans, including the potential for ads in your game feed, in this TWiST exclusive.PLUS domestic helper bots are here. NEO from 1X Technologies can do the laundry, open the door for guests, and even read and understand Post-It Note messages.Alex talks with CEO Bernt Børnich about building the safety-first 66-lb humanoid, why world models are so crucial for training robots in particular, and why homes are even tougher places for robots to navigate than factory floors.Timestamps:0:59 Nanogram co-creators Albert and Boris join the show3:42 Nanogram is TikTok for casual AI-generated games4:27 Building Nanogram with Google Gemini5:49 Draper and Associates: https://www.draper.vc6:11 Integrating ads into the game feed7:36 Roblox: https://www.roblox.com World of Warcraft: https://worldofwarcraft.blizzard.com8:25 Building in New York9:07 Jason is obsessed with the Staples Baddie https://www.tiktok.com/@blivxx10:12 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist20:36 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io21:40 1X CEO and founder Bernt Børnich joins the show https://x.com/BerntBornich22:31 Designing robots to actually live around people26:30 Teaching NEO about movement in the physical world29:00 TechCrunch coverage: https://techcrunch.com/2026/01/13/neo-humanoid-maker-1x-releases-world-model-to-help-bots-learn-what-they-see/29:58 Render: Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.31:04 Moving beyond training data to true general intelligence33:17 Ensuring NEO pursues the safest possible path34:19 Why are world models so important?41:51 1X World Model Challenge on GitHub: https://github.com/1x-technologies/1xgpt45:14 Robots need to train on a lot of data… Where does it all come from?50:14 Manufacturing NEO from raw materials in San Carlos56:32 Robots building robotsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Sentry - https://sentry.io/twist Deel - https://deel.com/twist Netsuite - https://netsuite.com/twist Plaud - https://Plaud.ai/twistToday's show:*TAO just had its worst week since launch. One of Bittensor's most prominent subnet operators allegedly dumped $10 million in tokens and walked away. We're digging into what we know, how this could change the Bittensor community… and why dedicated builders still believe in this ecosystem.Jason and Lon are joined by Stillcore Capital Partner Mark Jeffrey to break down the Covenant AI and Templar controversy in real time. Then they're joined by three prominent subnet founders: Ken Miyachi of BitMind (Subnet 34) and Will Squires of Steffen Cruz of MacroCosmos (which owns Subnets 1, 9, and 13). Together, they're investigating how Bittensor incentives work, how real products are still emerging from the TAO ecosystem, and what governance fixes could arise to prevent the next (alleged) rug pull.Timestamps:0:00 Mark Jeffrey joins the show! https://x.com/markjeffrey2:18 How Mark Jeffrey learned about Bittensor. https://bittensor.com/6:17 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!7:22 Mark Jeffrey's Bittensor investments. https://stillcorecapital.com/9:25 Check out our discussion with Nova: https://youtu.be/gjRt4eUyiYc?si=HopdmmSarxECark110:16 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST10:41 Check out Ridges! https://www.ridges.ai/11:53 How trading alpha tokens works on Bittensor12:44 Subnet drama: what happened? https://x.com/covenant_ai/status/204238015283195130016:01 Do subnet owners have too much power?18:33 Check out our conversation with Sam Dare (2268): https://youtu.be/TN2RmNuX4-k?si=c58Byh7Fsw1ttnAY19:10 How Sam Dare should've handled walking away (per Mark Jeffrey)20:02 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.23:29 Who should subnets be owned by?24:02 Ken Miyachi from BitMind joins the show https://x.com/kenmiyachi30:56 Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist31:06 Ken's $3M raise & investors (Arch, Canonical, Mechanism)33:18 Token vs. equity: how to think about a subnet investment.41:57 Will Squires and Stefan Kruse of MacroCosmos join the show https://x.com/willsquires https://x.com/sczsteffencruz56:29 Stefan on the Covenant drama: "disappointing, but solvable"1:02:11 Off-duty with J-Cal, Mark Jeffrey, and Lon Harris1:02:48 Bieber vs. Carpenter: does Coachella owe you a spectacle? https://www.youtube.com/watch?v=hp5O72WUqTk https://x.com/FashionXGirl_/status/20432512705095929361:15:20 Jason says Staples should pay the "Staples baddie" $1M/year https://www.tiktok.com/@blivxxSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Lawmakers in Ohio are looking to ban sports betting in Ohio against the will of Ohio voters. Scott talks with Ohio Senator Steve Huffman about why Republicans can't stop overruling the people.

Lawmakers in Ohio are looking to ban sports betting in Ohio against the will of Ohio voters. Scott talks with Ohio Senator Steve Huffman about why Republicans can't stop overruling the people.See omnystudio.com/listener for privacy information.

Lawmakers in Ohio are looking to ban sports betting in Ohio against the will of Ohio voters. Scott talks with Ohio Senator Steve Huffman about why Republicans can't stop overruling the people.

Lawmakers in Ohio are looking to ban sports betting in Ohio against the will of Ohio voters. Scott talks with Ohio Senator Steve Huffman about why Republicans can't stop overruling the people.See omnystudio.com/listener for privacy information.

Anthropic just built a model so dangerous, they're not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction.Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council.Together, they'll test how quickly and easily the model can thwart today's most elite cybersecurity protocols, and try to develop fresh protocols to keep our most sensitive and critical software systems safe and intact. Once Mythos or a similarly powerful model hits the streets… it's all over!Plus, we're checking out the real-time SaaSpocalypse monitor Death By Clawd, and chatting with its creator, Gyani, about how it feels to have your startup one-shotted by Anthropic's latest model.GuestsRob May: https://x.com/robmayNeurometric: https://www.neurometric.ai/Neurometric SLM Marketplace: https://marketplace.neurometric.ai/Death by Clawd: https://deathbyclawd.com/Nick O'Neill: https://x.com/chooserichThis Week In Startups is made possible by:LinkedIn Jobs - LinkedIn.com/twistGrasshopper Bank - Grasshopper.bank/twistRender - Render.com/twistPlaud - https://Plaud.ai/twistToday's show:Timestamps:0:00 Anthropic's new, powerful 'Mythos' model3:50 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!5:26 Neurometric's Rob May joins the show10:04 Sam Altman's talent exodus10:50 Render - Go to https://render.com/twist to apply for the Render Startup Program. You'll get anywhere from $500 to $100,000 in free credits.11:50 Has Anthropic Passed OpenAI?15:44 When will Claude release Mythos? Polymarket: https://polymarket.com/event/claude-mythos-released-by18:32 The AI race turns existential19:16 Would Anthropic's model give the CIA the ability to hack a foreign government?20:04 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.21:19 Should AI be nationalized?29:43 Subsidizing secret AI development.30:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist31:29 How much of the military's $1.5T will go to AI cybersecurity?35:17 Nick O'Neill's "not sponsored" call-in.38:24 What is an SLM?42:01 Tactical/Practical: How can you tune SLMs45:43 How Neurometric can afford 100M free tokens per month for its users?49:04 What is "harness engineering"?50:58 Tactical/ Practical: Every Reddit rant is a startup idea1:00:25 Why Meta is the most un-innovative AI company in the world.1:03:43 Gyani of Deathbclawd joins the show — Is your company COOKED?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it's going to cost now, and whether this is truly the end of the subsidized AI era.And they all brought demos! We're checking out ClawChief from Ryan Carson, Alex Finn's agent Henry, and Yazin Alirhayim's Sidecast protocol, inspired by a special request from JCal!HostsJason Calacanis: http://x.com/jasonLon Harris: https://x.com/lonsGuestsRyan Carson: https://x.com/ryancarsonClawchief: https://github.com/snarktank/clawchiefAlex Finn: https://x.com/AlexFinnCreator Buddy: https://www.creatorbuddy.io/Yazin Alirhayim: https://x.com/yazinsOpenOats / Sidecast: https://github.com/yazinsai/OpenOatsFurther ReadingThe Checklist Manifesto by Atul Gawande: https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000Marc Andreessen on AI job loss: https://x.com/pmarca/status/2040919227641856307OpenAI acquires TBPN: https://openai.com/index/openai-acquires-tbpn/This Week In Startups is made possible by:Gusto - https://Gusto.com/twist Vanta - https://vanta.com/twist Shopify - https://shopify.com/twist Plaud - https://Plaud.ai/twistToday's show:Timestamps:0:00 Welcome back to TWiST0:32 Jason's thinks Andor is as good as Empire Strikes Back…2:30 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:26 Check out the checklist manifesto! https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/03124300006:36 Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show10:28 Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at https://Gusto.com/twist.10:46 People are automating their coworkers and getting them fired…18:32 Anthropic Bans OpenClaw20:06 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist24:06 How "caveman talk" makes AI works better27:31 Alex thinks $2000/ month subscription plans are inevitable for AI.29:31 Why is nobody using the leaked Anthropic Model?30:30 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist32:37 Open models have been 6 months behind for the past few years35:53 Why did OpenAI acquire TBPN?42:01 Tactical/ Practical: The product itself is the most important thing44:31 Demo or Die! Yazin is back to show off OpenOats55:05 Ryan's "Claw Chief" https://github.com/snarktank/clawchief/blob/main/skills/executive-assistant/SKILL.md?plain=11:02:14 Alex's big announcement, "Henry intelligent machines"1:12:33 Alex Finn DESTROYS Higgsfield's marketing strategy1:15:35 Throwback to "Pay Per Post"Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Deel - deel.com/twistGrasshopper Bank - grasshopper.bank/twistRender - render.com/twistPlaud - Plaud.ai/twistAn AI “holding company” rebuilt dozens of YC Winter ‘26 startups in one weekend. Now we're bringing the founder responsible into Jason's Courtroom to defend himself.PLUS a live demo of Boardy, the AI that acts like a virtual board member and makes crucial introductions. Find out why he gets to have so much agency, how creator Andrew D'Souza used him to raise his own $17 million round, and how this company ever plans to actually make money.Plus Jason celebrates Apple's 50th anniversary with a fiery rant about milking the ghost of Steve Jobs… Why OpenAI is acquiring a tech podcast… Jason's favorite weighted vest for rucking… AND Lon's Off Duty weekend streaming picks.GuestsMarik Hazan:⁠ https://x.com/MarikHazan⁠Feltsense:⁠ https://feltsense.com/⁠Andrew D'Souza:⁠ https://x.com/andrewdsouza⁠Boardy:⁠ https://www.boardy.ai/⁠Timestamps:0:00 Jason's direction for TWiST and thoughts on legacy media5:14 Marik of Feltsense joins the show6:10 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!7:10 Marik's viral YC replicator stunt9:45 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.20:39 Grasshopper bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.21:33 Feltsense founder goes on trial!25:26 Jason dunks on Bank of America's app27:59 TBPN acquired by OpenAI29:28 The All In Podcast is worth $1B!30:13 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.33:02 Andrew D'Souza joins the show along with his agent, Boardy!43:17 So how does Boardy make money?48:32 Lon is becoming more and more "AI-pilled."50:41 Tactical/ practical: "If we have data, let's look at data. If all we have are opinions, let's go with mine." -Jim Barskdale, former CEO of Netscape1:01:00 Tactical/ practical: hire a PR firm to report on your competitors' wrongdoings.1:02:58 Jason calls out Apple for being DISGRAZIAD!1:15:09 Lon's TV pick of the week: "Something Very Bad is Going to Happen https://www.youtube.com/watch?v=vMc_pWm7G7o1:19:52 Become an Angel Investor at https://thesyndicate.com/Subscribe to the TWiST500 newsletter:⁠ https://ticker.thisweekinstartups.com⁠Check out the TWIST500:⁠ https://www.twist500.com⁠Subscribe to This Week in Startups on Apple:⁠ https://rb.gy/v19fcp⁠Follow Lon:X:⁠ https://x.com/lons⁠Follow Alex:X:⁠ https://x.com/alex⁠LinkedIn:⁠ ⁠https://www.linkedin.com/in/alexwilhelm⁠Follow Jason:X:⁠ https://twitter.com/Jason⁠LinkedIn:⁠ https://www.linkedin.com/in/jasoncalacanis⁠Check out all our partner offers:⁠ https://partners.launch.co/⁠Great TWIST interviews:⁠ Will Guidara,⁠⁠ Eoghan McCabe⁠,⁠ Steve Huffman⁠,⁠ Brian Chesky⁠,⁠ Bob Moesta,⁠⁠ Aaron Levie⁠,⁠ Sophia Amoruso⁠,⁠ Reid Hoffman⁠,⁠ Frank Slootman⁠,⁠ Billy McFarland⁠Check out Jason's suite of newsletters:⁠ https://substack.com/@calacanis⁠Follow TWiST:Twitter:⁠ https://twitter.com/TWiStartups⁠YouTube:⁠ https://www.youtube.com/thisweekin⁠Instagram:⁠ https://www.instagram.com/thisweekinstartups⁠TikTok:⁠ https://www.tiktok.com/@thisweekinstartups⁠Substack:⁠ https://twistartups.substack.com⁠

This Week In Startups is made possible by:PaperOS - https://PaperOS.com/twistNorthwest Registered Agent- https://northwestregisteredagent.com/twistEvery.io - https://Every.ioPlaud - https://Plaud.ai/twistToday's show:Silicon Valley just lined up its biggest liquidity event in years: SpaceX filed confidentially for an IPO that could target a $1.75 trillion valuation — potentially the largest public offering in history. Meanwhile, a new Quinnipiac poll shows that 62% of Americans aren't excited about AI, and 70% think it will destroy their jobs. The disconnect between Sand Hill Road and Main Street has never been wider, and this panel is here to argue about what to do about it.Jason Calacanis and co-host Alex Wilhelm are joined by Delian Asparouhov, Partner at Founders Fund and co-founder of Varda Space Industries; Salen Churi, General Partner at Trust Ventures, focused on regulated industries and physical infrastructure; and Larsen Jensen, Founder and GP of Harpoon Ventures and former Navy SEAL.They dig into the SpaceX IPO and what it means for LP liquidity, founder formation, and venture capital's comeback story; the gap between Silicon Valley's AI optimism and public hostility; whether defense tech is in a bubble after $49 billion flooded the sector in 2025; the Marc Andreessen "zero introspection" thesis for founders; America's reindustrialization challenge and the rare earths supply chain crisis; and Artemis's path to putting boots back on the Moon.Timestamps:00:00 Intro1:09 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:50 SpaceX files confidentially for IPO: $1.75T valuation, June target9:00 Will the SpaceX IPO reinvigorate venture capital?10:25 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io14:40 Quinnipiac poll: Americans use more AI but trust it less17:31 AI's PR crisis: Dario vs. Jensen, and who's communicating well18:02 Jason's "Invest America" proposal: give workers equity stakes19:55 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://northwestregisteredagent.com/twist21:39 Larsen: Silicon Valley is walking into the same trap as China offshoring29:04 PaperOS - Whether you're raising a round, launching a fund, or managing a venture portfolio, PaperOS can unlock simplicity and scale across your empire of capital, contracts, and companies. Claim your $10,000 credit at https://paperos.com/twist29:50 Polymarket: 24% chance of a federal AI data center moratorium33:57 Marc Andreessen on zero introspection (David Senra podcast clip)46:48 Is defense tech in a bubble?1:10:32 Saronic raises $1.75B for autonomous drone boats1:25:07 Anthropic vs. OpenAI: where would you put your entire net worth?Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Quo - https://quo.com/TWiSTLinkedIn Jobs - https://LinkedIn.com/twistIru - https://iru.com/twistPlaud - https://Plaud.ai/twistToday's show:Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters.He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team:Start with one agent and onboard them like a new hireStop Googling fixes; just ask your agent how to use itPut your agents on fixed schedulesAdd shared memory so you don't have to repeat yourselfLet agents run self-reviews and rewrite their own instructions.Get the walkthrough to put this entire plan into practice on today's episode. PLUS fresh demos of the “Minecraft”-inspired virtual workspace MoltWorld and AgentMail, which is Gmail for your AI pals, and Jason explains the thinking behind his viral, controversy-stirring “don't talk to journalists” tweet.Follow Shubham: https://x.com/Saboo_Shubham_“How I Built an Autonomous AI Agent Team That Runs 24/7” on X: https://x.com/Saboo_Shubham_/status/2022014147450614038?s=20Follow Mike: https://x.com/mihalich1988MoltWorld: https://moltworld.io/Follow Haakam: https://x.com/haakamaujlaAgentMail: https://www.agentmail.to/Jason's post about talking to journalists: https://x.com/Jason/status/2037573025458016659NYT responds: https://x.com/NYTimesPR/status/2037648223771263082Translated Japanese tweets: https://x.com/melonneet40/status/2038020624015315289, https://x.com/rambling_28/status/2038041455999246422Japanese people singing “Country Roads”: https://x.com/harukaawake/status/2038081269830222259Trailer for “Nuremberg” (now on Netflix in the US): https://www.youtube.com/watch?v=WvAy9C-bipYTimestamps:0:00 Intro1:24 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:05 We're Claw-pilled once again; it's an all AI Agent showcase6:15 Google AI PM Shubham Saboo's Top 5 OpenClaw tips10:14 Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST.13:26 Tip #1 — Onboard your agent like a new hire17:31 Tip #2 — Talk to your agents constantly19:02 Tip #3 — Put your agents on a schedule19:51 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.23:41 Tip #4 — Add cross-agent memory29:33 Tip #5 — Let your agents self-improve29:51 Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://iru.com/twist!34:03 Why Jason says founders should avoid journalists38:24 How biased IS the New York Times?47:02 DEMO: Co-founder Mike Nosov shows us MoltWorld51:14 But what's the utility of this?1:05:15 DEMO: Haakam Aujla presents AgentMail (YC S25)1:09:59 How does AgentMail make money?1:17:03 How Grok Translations are creating cross-cultural dialogue on XSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanis

This Week In Startups is made possible by:Wispr Flow - https://wisprflow.ai/twistCircle - http://circle.so/twistDeel - http://deel.com/twistToday's show:AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk about the company's ambitious mission, what went wrong on their first two flights, and why Mission 3 could still change everything.PLUS Sam Dare from Templar stops by to talk about training AI models on a decentralized blockchain, and why it's so much cheaper and more efficient than the conventional “data center full of GPUs” method. AND a demo of OpenOats from creator Yazin Alirhayim of his open source Granola alternative.Astroforge: https://www.astroforge.com/Templar: https://www.tplr.ai/Epoch AI decentralized training post: https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scaleOpenOats on Github: https://github.com/yazinsai/OpenOatsTimestamps:0:00 Intro0:59 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:05 We aplaud Plaud!3:18 Astroforge is mining… asteroids?!6:11 How creating an abundance of Platinum will impact Humanity!9:56 Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.21:16 Circle: The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to https://circle.so/twist.22:01 How Astroforge uses capitalism to unlock abundance24:35 J-Cal subscribed to… A socialist magazine?26:19 Sam Dare of Templar joins the show!27:47 What is TAO doing that's uniquely different from Bitcoin30:15 What is the incentive mechanism that Templar uses?30:44 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.37:49 How much does it cost to run templar's model?45:16 Can decentralized training over the internet scale? https://epoch.ai/gradient-updates/how-far-can-decentralized-training-over-the-internet-scale47:16 Jason addresses his tao investment48:48 Why brand is the moat for startups49:47 When will a better, more exciting version of Bitcoin, can come along?52:20 Yazin of OpenGranola Joins the show53:36 How OpenGranola has local LLM's taking notes for you and giving you real time insights in your meeting!1:01:45 Jason's callout for a sidebar that shows all inputs from agents1:13:50 The economics of the new harry potter series and HBO/ Warner Brothers1:23:33 Why Jason wants government surveillance on Disney adults…Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistEvery.io -  https://every.ioLemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twistToday's show:What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.Metanova uses its subnet to run developer competitions to find exciting molecular candidates, parsing through a mountain of possibilities to pluck out the most promising for further investigation.Bitcast uses its subnet to collect visibility demand from brands, which is served by video creators. The company is focused on the crypto niche to start, but will expand in time to other technology topics.Score uses its subnet to generate highly performant, specialized vision models, which it then sells to customers through a platform (Manako).In each case, the Bittensor's economic engine unlocks global creativity to tackle tasks that were previously time-consuming, fragmented, or expensive to complete. Let's see how quickly each company can scale and whether startups building on Bittensor can grow faster than their non-decentralized peers.Timestamps:0:00 Intro2:19 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:40 What is Bittensor?7:22 Metanova Labs joins the show9:28 Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist17:16 How Metanova tackles the multi-billion dollar cost of drug discovery20:48 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io30:20 Bitcast joins the show31:23 Luma AI - Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at https://lumalabs.ai/twist32:30 Mining crypto with YouTube36:48 Why Bitcast is focused on the crypto space to start39:11 How healthy is the creator economy?47:26 When will the AI bubble collapse?53:44 Score joins the show54:42 How Score will make vision AI more accessible57:16 VLMs v. LLMs1:01:14 Demo of the Manako platformSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Northwest Registered Agent - https://www.northwestregisteredagent.com/twistCircle - https://circle.so/twistNetsuite - https://www.netsuite.com/twistToday's show:Zipline founder Keller Cliffton started his company with a simple premise: build automated logistics that serve everyone equally. The only problem? It was literally illegal in the US.In this live recording from LaunchFest in San Francisco, Keller shares how Zipline went from a 20-person team working on a cow farm in Rwanda to operating the largest commercial autonomous system on Earth. They now complete 130 million autonomous miles with zero accidents, while reducing maternal mortality by 51% in the regions they serve.PLUS we've got Rahul Vohra from Superhuman taking us through his entire founder journey, and discussing with Jason why “difficult” founders are often the smartest investments.Timestamps:0:00 Intro1:16 Keller Cliffton starts off the show3:05 Starting Zipline in Africa8:40 The magic of sky maps13:55 Building the drone was just the beginning15:11 Making a huge difference in maternal mortality23:48 The threats of Little Evil Jimmy and dogs29:37 The shift from Rwanda to Dallas31:14 Netsuite - Get the free business guide Demystifying AI at https://www.netsuite.com/twist32:28 The moral clarity of the mission41:17 The challenge of staying focused46:43 Rahul Vohra of Superhuman joins Jason49:40 Building Rapportive in Cambridge51:48 Scaling to millions of users via APIs1:11:46 How getting acquired made Rahul fearless1:12:31 The boldness of taking on Gmail1:22:12 Making everyone pay for the product1:31:24 Inside the Grammarly-Superhuman dealSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Deel - https://deel.com/twistLinkedIn Jobs - https://LinkedIn.com/twist.Iru - https://iru.com/twistToday's show:We've got a treat for you today on TWiST! Jason is live from LAUNCH Fest in San Francisco, where he's joined by Robinhood founder Vlad Tenev.The era of AI is here. Robinhood found success in the midst of the last great technological shift. What lessons did Vlad take from this, and how can founders apply these to this next transformative period? What elements are the same and what elements have changed?Let's get inside the mind of one of the greatest founders of the last decade!Timestamps:0:00 Why Jason runs events like LAUNCH Fest.3:25 The early days of Jason and Vlad.5:54 Why getting users before monetizing creates a bigger business.9:49 Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit https://deel.com/twist to learn more.11:03 Finding ways to launch a product multiple times.13:49 How Robinhood identified its initial customers.20:09 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.21:04 Robinhood's "give to get" and waitlist mechanics explained.25:07 Navigating mistakes that feel existential (they're not!)27:36 Leaning into negative press.30:30 Iru - Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://iru.com/twist32:13 Tackling competition in the AI era.37:20 How Vlad hires and develops talent.42:16 What is good design in an era of vibe coded slop?46:46 Vlad's top lessons from the last 10 years.Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Caldera + Lab - https://CalderaLab.com/TWISTNorthwest Registered Agent - https://northwestregisteredagent.com/twistLemon - https://Lemon.io/twistToday's show:Computers that read your mind? Jets that are all wings? Continuously tracking your body's vital signs to live longer? We've got all that and more on the show today.First, we sat down with the CEO of Paradromics, Matt Angle, to dig into the progress that his brain-computer interface startup has made. Yes, there are more companies working on BCIs than just Neuralink. Paradromics, in particular, is looking for early clinical trial subjects as it works to bring its technology out of the lab and into the market.If you ever wanted to know more about how BCIs work and how long it will be until we can all benefit from the tech, this is the interview for you.Next, we got JetZero CEO Tom O'Leary on the phone to tell us all about his startup's jet. No, it's not competing with Boom, a startup that wants to build a supersonic passenger airliner. Instead, JetZero is building jets that are mostly wing, allowing them to fly with far greater fuel efficiency. Best of all? The future JetZero planes can fit right into normal airports.Finally, we chatted with Nutrisense CEO Dan Zavorotny. While keeping tabs on your glucose levels may not be the sexiest topic in the world, the data that continuous monitoring can bring is incredibly valuable health information. Mix that signal with coaching, and Nutrisense reckons its combination of software, data, and dieticians can really improve health outcomes for its customers.If you needed a break from pure-play AI news, TWiST has you covered!Timestamps:0:00 Introduction1:47 Paradromics3:26 How do BCIs read your mind?9:58 Lemon - Get 15% off your first 4 weeks of developer time at Lemon.io/twist19:54 Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at northwestregisteredagent.com/twist27:24 JetZero29:07 The advantages of more wing30:13 Caldera Lab - Whether you're starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to CalderaLab.com/TWIST and use TWIST at checkout for 20% off your first order.55:30 NutrisenseSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisGreat TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Legendary British ad man Rory Sutherland invented a fake business on a podcast, a coffee shop appealing to the busy commuter called “Flat White or F**k Off.”But it's one thing to have a post go big on TikTok or Instagram… but to turn that viral moment into an actual COMPANY is a very different challenge.On TWiST, Jason and Lon chat with Charlie Hurst, Tom Noble, and Will Sudlow, founders of the online brand “Flat White or F**k Off,” about how they took a funny little slogan and turned it into a string of popular social media accounts, a line of merch, a pop-up café, and let's face it, an entire lifestyle.PLUS we've got Mog and Dubs from Subnet 75 — Hippius! Hear how they're using the blockchain for decentralized storage, and providing server space much cheaper than their famous hyperscaler rivals.This Week In Startups is made possible by:Plaud - https://Plaud.ai/twistLinkedIn Jobs - https://LinkedIn.com/twist.Wispr Flow - https://wisprflow.ai/twistNorthwest Registered Agent  - https://www.northwestregisteredagent.com/twistTimestamps:00:00:00 Intro00:01:28 Plaud - If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!00:03:22 What is "decentralized cloud storage"?00:05:42 How Hippius came together00:09:57 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.00:11:38 Incentivizing miners00:14:25 How many people are contributing?00:18:42 But where does the value accrue?00:20:18 Wispr Flow - Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.00:29:55 Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist00:35:53 The best places to eat in Dubai00:38:06 The inspo behind "Flat White or F Off"00:42:16 From social media to IRL business00:53:06 The secrets of experiential marketing00:57:28 Hospitality's "Rule of 3s"00:59:33 Inside the Flat White London pop-up01:13:11 Lon and Jason's Oscar picks01:26:06 Lon went "Inside the Manosphere"Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Circle - http://circle.so/twistSentry - http://Sentry.ioDeel - http://deel.com/twistPlaud - http://Plaud.ai/twistToday's show:It's self-driving time! We're going deep on one of the most exciting spaces developing in the world, autonomous vehicles! We've got 3 experts on the show to talk to us enlighten us, Ben Seidl of Autolane, Ming Maa of Moove, and Nathan Parker of EdgeCase.What's going on in the world of self-driving? How has the reliability of autonomous vehicles improved? What challenges are we still facing in the industry? Will the US reign victorious, or is China sneaking up? Let's find out on TWiST!Timestamps:00:00 intro02:21 Uber teams up with Zoox! 03:02 Does EdgeCase work with Zoox? 03:03 Operational design domains 06:47 The challenges of bringing self-driving to new environments. 00:10:53 Circle: The easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://circle.so/twist. 00:13:26 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at Plaud.ai/twist and use code TWIST for 10% off! 00:17:19 How has reliability of autonomous cars improved? 00:19:18 How Ben Seidl came up with the idea for Autolane! 00:21:08 Sentry: New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 00:27:47 How Moove helps autonmous vehicles go to market! 00:30:49 Deel: Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit https://deel.com/twist to learn more. 00:33:28 The logisitcs of managing fleets. 00:37:08 Why is it called Autolane and not multi-modal lane? 00:40:50 Does EdgeCase work with smaller self-driving vehicles as well? 00:41:52 How autonomous systems will interact with one-another! 00:43:14 Why AV's should not talk to other AV's on the road 00:45:07 The state of the self-driving market 00:49:12 Why Tesla isn't involving themselves in California 00:50:34 Why the US is leading the way with regulatory clarity in autonomous vehicles 01:02:51 Ben Seidl says federal regulation is a necessity 01:05:20 What is holding back self-driving growth in the US? 01:06:26 What companies make the most money in self driving Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Every Banking - https://Every.iohttps://Lemon.io - Lemon.io/twistWispr Flow - https://wisprflow.ai/twistPlaud - https://plaud.ai/twistRo.co - https://Ro.co/TwistToday's show:*Sure, we all love open source models, but what about completely decentralized AI? Rather than leaving the big decision-making in the hands of a few elite CEOs, shouldn't users have a say — and potentially even a stake — in how this incredible technology develops?On TWiST, we welcome Ala Shaabana of Crucible Labs, one of the co-founders of Bittensor. It's an open-source protocol powering a blockchain-based machine learning network. What does that mean? Users mine a crypto token — $TAO — but rather than using up their compute on solving extremely long equations, they devote it to actually powering a range of innovative AI apps (aka subnets).Plus we've got Mark Jeffrey, co-founder of the Bittensor Fund Stillcore Capital, to show us some of his favorite subnet projects, and walk us through how he trained his AI agent to mine crpyto.All that AND two amazing new OpenClaw demos.Mark Jeffrey: https://x.com/markjeffreyStillcore Capital: https://stillcorecapital.com/Ala Shaabana (Crucible Labs): https://x.com/CrucibleLabsMichael Ryaboy (Setup Claw): https://setupclaw.com/Pete and Maddie Reese (Bizzby AI): https://bizzby.ai/Timestamps:00:00 Intro01:28 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!04:11 The booming intersection of crypto, and AI agents05:49 Mark Jeffrey joins the show!06:13 Bittensor explained — how TAO subsidizes AI products07:37 Mark's top Bittensor projects00:10:40 https://Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io.00:12:20 How subnet tokens work00:17:34 How the Crucible Labs wallet simplifies subnet token allocation00:19:33 https://Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist00:22:42 The importance of private inference and encrypted AI prompts00:29:36 Wispr Flow: Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit https://wisprflow.ai/twist to get started for free today.00:33:07 How AI is restoring old movies and media!00:40:57 SetUpClaw's “set it and forget it” AI agents00:45:50 https://Ro.co: Ro's insurance checker will let you know if your coverage includes GLP-1s for FREE. Go to https://Ro.co/Twist for your free insurance check.00:54:35 “Off-duty” with Lon and JasonSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:LinkedIn Jobs - https://LinkedIn.com/twist.Deel - https://deel.com/twistIru - https://iru.com/twist!Today's show:It's a packed TWiST Today! WITH US, we've got Erik Voorhees of VeniceAI and Logan Allin of Fin Capital on to talk agents, crypto, and… you guessed it, OPENCLAW!Where does agentic AI meet the financial system? How will agents transact? And what does privacy look like in a world with omnipresent AI?Stick around for some demos! We've got George Pickett to demo OpenClaw studio and David Kaufman to show us what he's building at Siteline!Timestamps:00:04:31 What was Logan's original thesis in Circle?10:08 LinkedIn Jobs - Thanks to our partners at @LinkedIn! Post your job for free at https://⁠linkedIn.com/twist⁠ then promote it to get access to LinkedIn Jobs' new AI assistant.00:11:52 Logans thoughts on Open vs. Closed Source00:15:33 How to maintain privacy in AI20:02 Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit https://⁠deel.com/twist⁠ to learn more.00:23:29 Why LAUNCH's token usage is trending higher than payroll!00:25:05 How Fin capital uses personality types and AI to assess investments00:29:45 Why Erik thinks Anthropic's defiance of the federal gov. is bravery!32:10 Iru - Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://⁠iru.com⁠/twist!00:42:23 How Siteline is helping understand companies and their agent traffic.00:57:15 OpenClaw Studio makes OpenClaw as user friendly as possible.01:10:09 The layers and layers of Microstrategy's business model.01:11:44 Which AI tools are the most indispensable?01:12:25 How Jason uses the Grok button on threadsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

This Week In Startups is made possible by:Deel - http://deel.com/twistWispr Flow - https://wisprflow.ai/twistLuma AI - https://lumalabs.ai/twistToday's show:*$110 billion buys you 15% of OpenAI. Amazon, Nvidia, and SoftBank placed their bets on ChatGPT, which now has 900 million weekly active users and 50 million paying subscribers. Find out why Jason is anticipating the wildest J-Curve swing of all time, and believes we've ALREADY hit AGI… it's just not implemented yet.Plus a visit from our roving correspondent Nick O'Neill, checking in on the Crypto Chaos in Miami Beach, and hot demos from three young founders.GUESTS:Nick O'Neill: https://x.com/chooserichEverest Chris: https://openclaw.unloopa.com/Ben Broca: https://polsia.com/Adi Gabrani: https://makemyclaw.com/Timestamps:00:00 Intro01:33 We're hiring a new producer!05:42 OpenAI raised $110 billion08:59 Understanding the LLM J-Curve00:11:25 Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit ⁠https://deel.com/twist⁠ to learn more.00:15:02 CRYPTO CHAOS IN MIAMI BEACH!00:21:10 Wispr Flow - Stop typing. Dictate with Wispr Flow and send clean, final-draft writing in seconds. Visit ⁠https://wisprflow.ai/twist⁠ to get started for free today.00:22:54 Mass layoffs at Block00:30:50 Luma AI - Stop guessing and start directing with the all-in-one Dream Machine text-to-video platform. Visit ⁠https://lumalabs.ai/twist⁠ to try The Dream Machine for free.00:32:04 AI Scott Adams: The Saga Continues00:38:13 Make URLs for local businesses with Unloopa00:45:36 Rent a Polsia agent to run your company00:58:55 Deploy swarms in 60 seconds with MakeMyClaw01:05:05 LAUNCH FEST is coming to SF01:55:49 Will Paramount actually buy WBD?01:06:58 Why Lon loves “Knight of the 7 Kingdoms”01:07:21 On “Neighbors” and First Amendment Warriors01:13:43 All about Jason's favorite chargersSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com