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Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us
In this episode, Leigh Ann welcomes Dr. Scott Sherr, co-founder of Troscriptions, for a conversation on GABA, anxiety, stress, sleep, and fast-acting nervous system support. Dr. Sherr shares how his background in internal medicine, hyperbaric oxygen therapy, and health optimization medicine led him to help create products designed to support people while they are on a longer healing journey. He explains why many people may be struggling with GABA deficiency, how chronic stress can deplete the body's calming pathways, and why anxiety, insomnia, racing thoughts, and low energy are often interconnected. Leigh Ann and Dr. Sherr discuss the unique buccal troche delivery method, how it differs from capsules and sublingual supplements, and why it can allow for faster absorption and more flexible dosing. The conversation also explores TroCalm, Trozy, alcohol's impact on the GABA-glutamate balance, sleep architecture, and why calming the nervous system does not have to mean feeling sedated.Product Discount Codes + LinksHoolest: Website (Discount Code: THEACCRESCENT10)Froya Hair Care: Website (Link gives 10% off)Herbal Face Food: Website (Discount Code: LAL30)Episode LinksTroscriptions - Website (Discount Code: LEIGHANN)Guest InfoDr. Scott Sherr - WebsiteRelated EpisodesPodcast Ep. 203: Anna Finck - Reconnecting to Our Bodies, Reclaiming Our Health, and Remembering Our PowerPodcast Ep. 150: Michael Byrne - The Bia Smart Sleep MaskWork w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Healing Alchemy MembershipConnect w/Me & Learn MoreWebsiteInstagramTiktokYoutube
Hyperbaric oxygen therapy or HBOT is one of the most scientifically validated yet underutilized treatments in modern medicine. And Dr. Scott Sherr has spent his career proving exactly why. In this episode, Dr. Sherr board certified internal medicine physician, hyperbaric oxygen specialist, and COO of Troscriptions breaks down everything you need to know about HBOT: how it works at the cellular level, which conditions it treats, how to access it, and how to combine it with cutting-edge molecules like methylene blue for maximum results. Whether you're dealing with brain fog, chronic fatigue, long COVID, TBI, or simply want to optimize your health and slow down aging this episode is for you.
Our trusted source for Methylene Blue: https://www.troscriptions.com/muscle (10% off) Functional medicine Dr. Scott Sherr joins Ben Pakulski to break down methylene blue — the 100-year-old compound that's become one of Ben's favorite tools for energy, focus, and endurance. Dr. Sherr explains how it reboots mitochondrial function in days (not months), how one endurance athlete he coaches cut three hours off a 100-mile race, and how to dose it safely. Plus the warning most people never hear: why the majority of methylene blue sold online is contaminated, and what to look for in a clean source. In this episode… → The bottleneck behind almost everything (energy, brain, recovery, fat loss) → The four complexes of your electron transport chain, and where most men are blocked → Why statins might be quietly trashing the system you're trying to optimize → Which molecule does "ninja moves" for mitochondrial dysfunction → The exact dosing protocol Scott uses for performance, travel, sauna, and endurance About Dr. Sherr Dr. Scott Sherr is a board-certified Internal Medicine physician and one of the leading clinical voices on methylene blue and mitochondrial medicine. He is certified to practice Health Optimization Medicine (HOMe) — a root-cause framework he helped bring to the U.S. as founder of HOMe-SF, the country's first HOMe clinic — and is a specialist in Hyperbaric Oxygen Therapy (HBOT). He is the COO of Troscriptions (the precision-dosed troche company behind Just Blue, Tro+ Blue, and Blue Cannatine) and its parent, Smarter Not Harder, as well as COO of the nonprofit Health Optimization Medicine and Practice (HOMe/HOPe) USA, which trains doctors to detect and correct the root causes of health. He is also co-founder of OneBase Health, an integrative HBOT ecosystem. He has consulted for Upgrade Labs, Remedy Place, and other wellness ventures, and lives in Louisville, CO with his wife and four kids. Key credentials Board-Certified Internal Medicine Physician Hyperbaric Oxygen Therapy (HBOT) specialist COO, Troscriptions / Smarter Not Harder COO, Health Optimization Medicine & Practice (HOMe/HOPe) USA Co-Founder, OneBase Health Connect with Dr. Sherr Instagram: https://www.instagram.com/drscottsherr/ LinkedIn: https://www.linkedin.com/in/drsherr Website: https://drscottsherr.com/ Work with Muscle Intelligence The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply/ If you're interested in working with Ben. ben@muscleintelligence.com Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter
We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling. In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions. This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition. If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on. In this episode, we cover: Why brain fog is such a common midlife complaint What mitochondria actually are and why they matter for brain energy How estrogen loss may contribute to mitochondrial dysfunction How methylene blue may support mitochondria, energy production, and mental clarity The difference between low-dose and high-dose methylene blue use The truth about methylene blue and nitric oxide Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain How stress and sympathetic overload affect mood, sleep, and focus Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support Why HRT may help, but may not be the whole story for every woman Who this episode is for This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms. Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He's the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients. Troscriptions: Use coupon code HORMONE for 10% off your order. Sponsors Get 15% off Masszymes at bioptimizers.com/hormone Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back! Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication. Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are. Visit the website: https://karenmartel.com Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more! Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you). Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women. Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife. Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert Karen's Facebook Karen's Instagram
In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system.
There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we break down exactly what it is, why so many people are stuck in it without knowing it, and the right sequence to actually get out.Dr. Scott is a board certified internal medicine physician, certified in hyperbaric oxygen therapy and health optimization medicine, and the chief medical officer of One Base Health, the company behind the hyperbaric chamber you see in every episode. He advises me personally on my hyperbaric protocols, including the ovarian longevity protocol I have been running, and this conversation goes deep into the science behind why that protocol makes sense and what we are actually trying to achieve.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.https://zenbasil.com/shopzenbasil/zenbasilseedbagJoin the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityExplore Troscriptions' mitochondrial, immune, and nervous system support products. Use code KAYLA10 at checkout for 10% off.https://troscriptions.comIn This Conversation:- Why Autoimmunity Risk Rises In Women During Perimenopause - Why The Body Can't Heal When Stuck In Stress Mode- How Chronic Stress And Social Media Can Reduce Recovery Capacity- What Methylene Blue Does- Why The Gaba System Matters- When Hyperbaric Therapy HelpsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Scott Sherr and his work:Websites:drscottsherr.comhomehope.orgonebasehealth.comTroscriptions.comInstagram:https://www.instagram.com/troscriptions/https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/https://www.instagram.com/homehopeorg/Youtube:https://www.youtube.com/@troscriptionshttps://www.youtube.com/@drscottsherrLinkedIn:https://www.linkedin.com/in/drsherr/https://www.linkedin.com/company/troscriptions/https://www.linkedin.com/company/onebasehealth/
In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization and the "more is better" mentality. They explore real clinical case studies of patients who inadvertently damaged their health by blindly following supplement trends. Join us as we delve into: The dangers of over-supplementing with high-dose Fish Oil and Vitamin B6. How shifting to an "Omega-3 dominant" ratio can actually hinder your immune system's ability to heal injuries. Why you should treat metabolomic testing like the dashboard of a car to prevent the "check engine light" of chronic disease. How clinical metabolomics allows you to stop guessing and start subtracting unnecessary pills from your daily routine. This episode is for you if: You are experiencing wellness burnout and taking a massive handful of supplements every day without knowing if they are working. You want to understand the difference between being "fit" (e.g., running a marathon) and being truly cellularly "healthy." You are curious about functional testing and how it differs from the standard disease-focused bloodwork at a primary care clinic. You want a clear strategy to cut through social media influencer noise and build a foundational, personalized health protocol. You can also find this episode on… YouTube: https://youtu.be/WSNOBi1e7WY Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its reputation as just a performance supplement for "gym bros," Boomer Anderson, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Ted Achacoso break down how creatine functions as a critical cellular battery buffer. Join us as we delve into: How creatine bypasses the "methylation tax" by saving the body from depleting SAMe reserves to produce energy. Why muscle is a metabolic determinant of resilience and not just a cosmetic feature. The evolutionary mismatch that increases our cellular energy demands due to a highly sympathetic, stressed lifestyle. The role of creatine in brain health is particularly important for supporting working memory, mitigating cognitive fatigue, and protecting against excitotoxicity. This episode is for you if: You are curious about how to support your body's cellular energy and mitochondrial function. You follow a vegetarian or plant-based diet and want to understand your specific creatine supplementation needs. You want to understand the difference between maintaining muscle for aesthetic reasons versus metabolic health. You are looking for strategies to mitigate mental fatigue and sleep deprivation. You can also find this episode on... YouTube: https://youtu.be/R4x9tu56FXg Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you've been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You're not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES 744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn't Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen
In this episode of the HOMe Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz explore a foundational principle of Health Optimization Medicine: What's toxic to the cell is toxic to every organ. Through real clinical cases — including mercury toxicity, arsenic exposure, and environmental toxin accumulation — the team reveals how modern medicine often misses the root cause of disease by focusing on isolated organ systems instead of cellular function. From chronic low-level toxin exposure to acute breakdown events, this episode highlights how toxins disrupt mitochondrial energy production, leading to widespread dysfunction across the body. Most importantly, the conversation emphasizes the role of metabolomics in identifying these hidden stressors early — before they manifest as disease. Join us as we delve into: • Why toxins affect every organ through the cell • A real case of mercury toxicity missed by multiple specialists • How chronic exposure becomes acute illness • Why traditional medicine misses root causes • The role of mitochondria in energy production and health • How metabolomics detects early toxicity and dysfunction This episode is for you if: • You want to understand the root cause of chronic illness • You're exposed to environmental toxins (food, water, air) • You're interested in preventative and optimization-based medicine • You want to take a proactive approach to long-term health You can also find this episode on…Youtube: https://youtu.be/CMhFC5IUKl0 Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with JJ Virgin — nutrition expert, bestselling author, and founder of the Health Business Growth Collective — to explore how healthcare practitioners can build trust, authority, and impact in today's rapidly evolving landscape. With the rise of AI and what JJ calls a "trust recession," the traditional ways of building a practice are no longer enough. Instead, practitioners must learn how to stand out as a trusted authority — combining credibility, authenticity, and real-world proof. JJ breaks down her powerful "Trusted Authority Framework," explaining how clinicians can differentiate themselves, connect with patients, and grow their influence without becoming influencers. This episode is a must-listen for practitioners looking to grow, scale, and future-proof their practice in the age of AI. Join us as we delve into: The "Trust Recession" and why it's reshaping healthcare The difference between being an influencer vs a trusted authority Why vulnerability and storytelling build trust faster than credentials How to develop a contrarian stance that defines your expertise The power of patient stories as proof (and why they outperform credentials) Why most practitioners struggle with imposter syndrome — and how to reframe it This episode is for you if: You're a practitioner looking to grow your practice You want to build authority without becoming a social media influencer You're navigating AI, personal branding, and patient trust You want to stand out in a crowded health and wellness space You can also find this episode on… YouTube: https://youtu.be/rmyDXStM_Dk Find more from JJ Virgin Website: https://jjvirgin.com Health Business Growth Collective: https://hbgc.co Instagram: https://www.instagram.com/jj.virgin/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
What if a 150-year-old compound could still outperform modern solutions? I'm so excited to dive into the world of mitochondrial health today with Dr. Scott Sherr, a physician who specializes in health optimization and chronic illness protocols. We're exploring the fascinating history and science of methylene blue, a powerful tool that can help you reclaim your energy and support your body's natural detoxification processes. You'll learn why this "old-school" dye is hitting the zeitgeist and how to use it safely to age powerfully. What you'll learn: (00:00:11) What methylene blue is and how it was originally developed as a textile dye. (00:00:54) How methylene blue became one of the first synthetic antimicrobial drugs in history. (00:01:35) Why the “natural vs synthetic” debate can be misleading for your health decisions. (00:03:24) How methylene blue supports mitochondrial function and energy production. (00:03:59) Why you feel fatigued on airplanes and how oxygen levels impact your body. (00:04:54) Who may benefit from daily methylene blue use and who may not need it. (00:06:01) How to dose methylene blue properly for energy, stress, and performance. (00:09:04) Why supplement quality and testing are critical for safety and effectiveness. Watch the full episode: https://youtu.be/UKIJcM5zhWs?si=pR_nDOlBeL6UdWIP Full show notes (including all links mentioned): https://jjvirgin.com/hyperbarichealth Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Ted Achacoso, Dr. Scott Sherr, and Jodi Duval explore mental health through the lens of health optimization medicine. Rather than viewing mental health as a set of diagnoses, the conversation reframes it as a function of cellular health — where brain function is driven by mitochondrial performance, inflammation, nutrient status, and environmental inputs. From neurotransmitter imbalances to brain inflammation and the gut-brain-microbiome axis, this episode breaks down how modern stressors, lifestyle, and environment impact mental health at the cellular level. Most importantly, the team explains why true mental health optimization must begin with optimizing the health of the cell. Join us as we delve into: • Why mental health should be viewed at the cellular level • The role of mitochondria in brain energy and signaling • Brain inflammation and its impact on mood and cognition • The gut-brain-microbiome axis and neurotransmitter production • Why stress, sleep, and environment drive mental health outcomes This episode is for you if: • You struggle with brain fog, anxiety, or low mood • You want a deeper, root-cause understanding of mental health • You're a practitioner looking beyond traditional psychiatry • You want to optimize cognitive performance and resilience You can also find this episode on…YouTube: https://youtu.be/5xqAzkMUpBs Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
Dr. Scott Sherr is a clinician, hyperbaric medicine specialist, co-founder of Troscriptions, and one of the founding faculty of the Health Optimization Medicine and Practice nonprofit — and in this return episode, he comes with a very different perspective than his first appearance. What changed? He stopped putting everyone in the chamber. In this conversation, Scott and Freddie unpack the two hyperbaric chamber deaths that shook the industry in 2025 — what actually went wrong, what safety standards clinics and home users are missing, and why a sympathetically dominant nervous system may render even the best biohacking tools completely ineffective. From there they go deep on mitochondrial function as the master upstream driver of energy, detox, digestion, healing, and longevity — and why most people need to subtractbefore they can optimize. The second half of this episode is a complete masterclass on methylene blue — what it actually does at the mitochondrial level, how to find your ideal dose (hint: you'll know within three to five days), why 94% of American adults are metabolically compromised enough to benefit from it, and how one ultramarathoner shaved three hours off his Leadville 100 finish time using it strategically. Scott and Freddie also tackle epigenetic age testing, immunosenescence, the dopamine-draining effects of smartphones on libido and focus, and why screen time may be the most underrated threat to your nervous system recovery. Plus — a full breakdown of the Troscriptions product suite: TruCalm, TruZ, TruImmune, and methylene blue's role in each.Episode Highlights [04:27] – Dr. Scott explains how his work now spans clinical care, practitioner training, and product development [06:35] – Why mitochondrial function has become the foundation of his approach to health and recovery [07:42] – What likely caused recent hyperbaric chamber accidents and why safety protocols matter [13:12] – Why stacking devices inside a chamber creates unnecessary risk [15:16] – The problem with influencer protocols and overcomplicating health routines [18:52] – Soft-shell vs. hard-shell chambers and how pressure impacts oxidative stress [22:42] – A practical framework for intensive vs. maintenance hyperbaric use [27:59] – Why direct mitochondrial testing is limited and how metabolomics fills the gap [29:55] – Common signs of mitochondrial dysfunction, from brain fog to poor recovery [35:53] – Dr. Scott revisits methylene blue and challenges common misconceptions [39:28] – Why most people may benefit from mitochondrial support despite “not being sick” [41:44] – How to think about dosing and what a proper response should feel like [44:04] – The role of sympathetic dominance in blocking healing and recovery [46:04] – Why longevity metrics need context beyond just improving numbers [50:16] – How screen time and dopamine overload impact energy, libido, and focus [53:08] – The expanding Troscriptions product line and the goal of needing less over time Scott's First Episode: https://open.spotify.com/episode/42vjXWQ9HAFqOd2avJsj6n?si=76da7d2114694e6a Links & Resources Connect with Dr. Scott Sherr: https://www.instagram.com/drscottsherr/ Buy Troscriptions: https://troscriptions.com/?rfsn=9066612.3f3859&utm_source=refersion&utm_medium=affiliate&utm_campaign=9066612.3f3859 Use Code: BeautifullyBroken Silver Biotics: https://bit.ly/3JnxyDD Use Code: beautifullybroken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
What early signs could indicate your metabolism is breaking down? I sat down with Dr. Scott Sherr, a physician focused on health optimization and mitochondrial function, to unpack why so many women feel exhausted despite doing everything “right.” We explored how chronic stress and declining energy production create a hidden cycle that leaves you burned out, especially in midlife. I wanted to help you understand what's really going on beneath the surface so you can start rebuilding your energy and resilience. Today's topics: (00:00) What the “sympathetic spiral of doom” is and how constant stress keeps your body stuck in overdrive. (00:44) How mitochondria produce energy and why your body struggles when demand exceeds capacity. (01:19) Why hustle culture and chronic stress deplete your energy reserves over time. (02:12) How midlife hormonal changes amplify fatigue, weight gain, and poor recovery. (03:27) Why this issue is more widespread than most people realize and often goes undetected. (06:17) How your body compensates for dysfunction until it suddenly crashes. (07:14) The difference between top-down stressors and bottom-up biological dysfunction. (10:48) Why supporting mitochondrial health first is key before addressing stress directly. Listen to the full episode: https://youtu.be/SHtizobaR1E?si=kjk4MPmOwgzjFYz9 Full show notes (including all links mentioned): https://jjvirgin.com/cellularhealth Learn more about your ad choices. Visit megaphone.fm/adchoices
This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection
What if feeling better didn't have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn't what it used to be, and there's a constant sense of stress that doesn't seem to resolve. We walk through what's actually happening beneath the surface, why it can be so hard to break out of that pattern once you're in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What's keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn't always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn't have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Korrus, Timeline, BON CHARGE, BIOptimizers and Pique. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. (0:00) Introduction and guest Dr. Scott Scherer (3:31) Understanding the sympathetic spiral of doom (5:06) Symptoms and signs of sympathetic overdrive (7:10) Sympathetic activation, mitochondrial function, and stress (10:02) Mitochondria: their role and impact in the body (12:31) Stress, metabolic dysfunction, and their effects (17:43) Nervous system, mitochondria, and the cell danger response (21:25) Survival, stress, and breaking the sympathetic spiral (23:11) Contributors to stress: top-down and bottom-up (25:56) Mitochondria, microbiome, and medication impacts (29:38) Mitochondrial dysfunction and mental health (32:19) Limitations of parasympathetic activation and addressing root causes (36:46) How mitochondrial stress leads to fight-or-flight (37:52) Steps to break the sympathetic spiral and support mitochondria (42:41) Methylene blue: benefits, uses, and safety (50:35) Methylene blue as an MAO inhibitor and for chronic infections (57:17) Case studies, third-party testing, and Transcriptions' evolution (1:02:36) Parasympathetic edge, recovery, and the GABA system (1:07:44) GABA, supplements, and interventions for stress (1:12:23) Addressing root causes and methylene blue usage (1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem (1:19:49) OneBase Health, hyperbaric space, and final information
What happens when chronic stress and low energy begin feeding each other in a loop that feels impossible to escape? This week on Health Coach Talk, Dr. Sandi welcomes Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization medicine and hyperbaric oxygen therapy, for a fascinating conversation about the connections between the nervous system, mitochondrial health, and healing. Together, they explore why so many people feel “wired but tired” and what may be happening beneath the surface when clients are doing all the right things but still not feeling better.Full show notes: https://functionalmedicinecoaching.org/podcast/scott-sherr-175/
In this episode of the Forum Health Integrative Medicine Podcast, Dr. Scott Sherr breaks down the central role of mitochondria in energy production, aging, and chronic disease. He explains why modern lifestyles—marked by stress, toxins, and poor nutrition—disrupt cellular function, leading to symptoms like fatigue, brain fog, and anxiety. The conversation explores how methylene blue works as both an energy enhancer and antioxidant, supporting mitochondrial efficiency while reducing oxidative stress. From clinical applications in chronic illness to performance benefits for athletes and high achievers, this episode highlights a powerful shift in medicine—from treating symptoms to restoring cellular health.- - - - -About the Guest:Dr. Scott Sherr is a Board-Certified Internal Medicine Physician and a pioneer in Health Optimization Medicine and Hyperbaric Oxygen Therapy. As the Chief Medical and Health Education Officer and co-founder of Troscriptions, he focuses on restoring balance at the cellular level using tools like methylene blue, metabolic testing, and oxygen-based therapies.His work bridges the gap between advanced medical technologies and foundational health, helping both high performers and chronically ill patients improve energy, recovery, and resilience.- - - - -Social Handles:YouTube: https://www.youtube.com/@troscriptionsInstagram: https://www.instagram.com/drscottsherr/Website: https://drscottsherr.com/LinkedIn: https://www.linkedin.com/in/drsherrTroscriptions: https://troscriptions.com/- - - - -Forum HealthWebsite: https://forumhealth.com/Clinic Locator: https://forumhealth.com/clinics/Follow us on Social:Facebook: https://www.facebook.com/forumhealthco/Instagram: https://www.instagram.com/forum_health/- - - - -PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.comhttps://drtalks.com/podcast-service/
In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.Ready to nerd out in this with us?Let's dive in!What's Discussed:(4:00) The number that changes how you think about skin aging.(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.(8:18) The three enzyme families consuming your NAD+ as a substrate.(8:23) Sirtuins: the police of your cells and what they cost you.(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.(11:16) CD38: the NAD+ Pac-Man that gets worse with age.(15:10) The five-fold decline: what the 2012 tissue study actually found.(16:15) CD38 and the zombie cell feedback loop driving the decline.(19:39) What the depletion actually looks like in the mirror.(28:04) Why NAD+ decline is reversible & supplementation deep dive.(28:41) NMN: how it works and what the studies actually show.(31:50) NR: the most clinically studied precursor and who it's best for.(33:27) Niacin: the $5 option and why most people can't tolerate it.(38:14) Why timing your NAD+ to your circadian rhythm matters.(38:35) TMG and methylation: what to stack and the two-to-one ratio.Learn more about NAD from our previous podcasts and videos:Previous NAD YouTube Videos:NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0 The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XM Previous NAD Podcasts:NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123 The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462 The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098 Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945 Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344 Research Studies Mentioned: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357 CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7 Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3 Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/ Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1 Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7 Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% offBody Cream: Head to younggoose.com/products/youth-body-cream for 20% off
In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems. Dr. Sherr also shares how he's used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework. Sponsors: TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde CODE: DRMIKE Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Coming up: ISSN 2026: https://www.sportsnutritionsociety.org/ Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:11 Why Methylene Blue Now 04:29 Scott Cher Origin Story 05:05 Health Optimization Framework 07:08 Transcriptions and Safe Sourcing 08:46 Natural vs Synthetic Debate 11:49 How Methylene Blue Works 17:42 Who Benefits Most 22:13 Athletic Performance and Recovery 29:41 Dosing Timing and MAOI Effects 32:13 Mitochondria and Fertility 32:28 Energy Anxiety and Brain Fog 33:13 Depression Beyond Serotonin 35:30 Stress Pathways and Cell Danger 37:00 ADHD or Sympathetic Overdrive 38:50 Recovery Metrics and Downregulation 42:21 GABA Support and BBB Clues 47:50 Building Mitochondrial Capacity First 51:35 Methylene Blue Dosing Guide 57:54 Where to Learn More 01:00:24 Podcast Wrap and Disclaimer Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw Connect with Dr Sherr: Instagram: https://www.instagram.com/drscottsherr/ Website: https://drscottsherr.com/ YouTube: https://www.youtube.com/@drscottsherr Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us
Could a low dose of methylene blue be the missing "bridge" to help you overcome chronic brain fog and fatigue? In this episode, I sit down with Dr. Scott Sherr, a leading expert in health optimization and hyperbaric medicine, to dive deep into the world of cellular energy and recovery. We explore why foundational health is the key to making "biohacks" like methylene blue and hyperbaric oxygen therapy actually work for your body instead of just causing more stress. My goal is to help you understand how to master your nervous system and support your mitochondria so you can age powerfully and maintain your independence for years to come. What you'll learn: (00:00) How methylene blue supports both energy production and detoxification at the cellular level. (05:33) Why calming your nervous system can initially feel uncomfortable—and why that's normal. (06:34) How shifting between stress and recovery states improves performance and reduces injury risk. (07:10) Why post-workout recovery habits like breathwork and rest are essential for results. (09:24) What methylene blue actually is and how it became a powerful tool for health. (13:30) How low oxygen environments like airplanes impact your energy and mitochondria. (22:57) The real benefits of hyperbaric oxygen therapy and who should use it. (34:41) Why your evening routine matters more than your morning routine for better sleep. Love the podcast? Here's what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you're ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/hyperbarichealth Learn more about your ad choices. Visit megaphone.fm/adchoices
Hyperbaric oxygen therapy is one of the most powerful tools in modern integrative medicine… but most people don't actually understand what it does or when it should be used. This week we are joined by Dr. Scott Sherr, a board-certified internal medicine physician and hyperbaric oxygen therapy specialist, to explore how oxygen under pressure influences healing at the cellular level. He unpacks how hyperbaric therapy supports stem cell activity, reduces inflammation, improves mitochondrial function, and helps the body repair itself more efficiently. Just as importantly, Dr. Sherr explains why timing matters and why advanced therapies often work best after foundational health systems are optimized first. The conversation also explores methylene blue for mitochondrial support and GABA's role in calming an overactive nervous system, offering practical insight into how energy, stress, and recovery are deeply connected. If you've ever wondered whether hyperbaric oxygen therapy could support brain health, chronic illness recovery, or long-term resilience, this episode brings clarity to what's really happening inside the chamber. Dr. Scott Sherr is a board-certified internal medicine physician, Health Optimization Medicine practitioner, and hyperbaric oxygen therapy specialist. He serves as Chief Medical and Health Education Officer at Troscriptions and works with integrative technologies supporting energy, recovery, and nervous system health. ✴️ Connect with Dr. Sherr on Instagram, YouTube, or Linkedin ✳️ Learn more about Dr. Sherr's work through his organizations Troscriptions, HomeHope, and One Base Health.
In this episode, Dr. Jockers sits down with Dr. Scott Sherr to break down why so many people are stuck in fight or flight and what it's really doing to your brain and body. You'll learn how GABA acts as the "brake system" for your nervous system and why low levels are linked to anxiety, poor sleep, and burnout. They also unpack why fixing stress is not just mental, but deeply biological. You'll get a clearer picture of what's actually going on inside your cells when you feel exhausted, wired, or mentally foggy. Dr. Sherr explains how your mitochondria play a central role in all of it and why supporting them can change how you feel day to day. They also talk about tools like methylene blue and oxygen therapy, and when they can actually make a difference. They also get into why constantly pushing harder isn't the answer, and how being able to slow your system down can actually improve your performance. You'll hear what it really means to shift into a parasympathetic state and why so many people struggle to get there. It may change the way you think about stress, recovery, and what your body actually needs. In This Episode: 00:24 Show Intro and Guest 05:04 Sympathetic Spiral of Doom Explained 08:40 The Parasympathetic Edge 12:32 GABA Gas and Brakes System 15:22 Gut Inflammation and GABA Connection 16:49 Safer Ways to Support GABA 19:55 Alcohol, Benzos and Dependence 22:26 Why Calming Alone Can Backfire 27:13 Mitochondrial Dysfunction Root Causes 30:29 Methylene Blue as an Energy Bridge 32:40 Methylene Blue Controversies 36:20 SSRI Safety Considerations 37:47 High Dose Clinical Use 38:27 Versus CoQ10, PQQ and Creatine 41:29 Hyperbaric Oxygen Basics 43:29 Acute vs Chronic Protocols 46:01 Chamber Pressure Differences 47:17 Health Optimization Medicine Explained 49:55 Trauma and the Sympathetic Loop 55:26 Vagus Nerve Tools and Limits 01:02:54 Performance, Recovery and Closing Insights If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday. Experience faster, more effective health optimization with Troscriptions. Their innovative buccal troche delivery system sends ingredients directly into your bloodstream for rapid results, bypassing the digestive system. Whether you need a boost in energy, immune support, or relaxation, Troscriptions has a solution for you. Visit Troscriptions.com/DrJockers and use the code DRJOCKERS for 10% off your first order. Most people have no idea how polluted their indoor air actually is. I didn't either until I looked into it. The air inside your home can be significantly worse than outside, which is a big deal when you're spending most of your time indoors. That's why I use Air Doctor. It removes 99.99% of contaminants like dust, mold, smoke, and even viruses, so you're breathing cleaner air every day. You can go to airdoctorpro.com and use the code NUTRITION to get up to $300 off. You'll also get a 30 day money back guarantee and a free 3 year warranty. It's one of the simplest upgrades you can make for your health. If you feel like you need caffeine or nicotine just to get through the day, you're definitely not alone. But there's a better option that doesn't come with the crash or the edge. Ultra Pouches give you clean, steady focus using ingredients like L theanine, Alpha GPC, and B vitamins. No caffeine, no nicotine, just smooth energy that actually feels good. Most people notice better focus, more stable energy, and even an improved mood. If you want to try it out, go to takeultra.com and use the code JOCKERS to get 15% off your order. It's a simple switch that can make a big difference in how you feel day to day. "Most GABA is made in the brain from glutamate using magnesium and vitamin B6. If you're deficient, your nervous system struggles to slow down." Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Visit takeultra.com and get 15% off with code JOCKERS Visit airdoctorpro.com using code NUTRITION. Visit Troscriptions.com/DrJockers and use the code DRJOCKERS for 10% off. Connect with Dr. Scott Sherr: Website: https://drscottsherr.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
Dr. Scott Sherr is a physician and health optimization expert focused on cellular performance and longevity. Through his HOMe framework, he helps high performers move beyond burnout by mastering foundational health, personalized data, and sustainable optimization strategies. Connect with Dr. Scott: Troscriptions: https://troscriptions.com/ One Base Health: https://onebasehealth.com/ Website: https://drscottsherr.com/ LinkedIn: https://www.linkedin.com/in/drsherr/ Instagram: https://www.instagram.com/drscottsherr
Why does your metabolism seem to grind to a halt even when you're doing everything "right"? I'm joined by Dr. Scott Sherr, a specialist in health optimization and internal medicine, to dive deep into why so many of us feel completely exhausted and metabolically stuck. We explore the "Sympathetic Spiral of Doom," a state where chronic stress and failing mitochondria leave you wired, tired, and unable to recover. You'll learn why supporting your cellular energy is the foundational first step to reclaiming your resilience and finally breaking free from the cycle of burnout. What you'll learn: (05:30) Why feeling wired and exhausted at the same time is a major red flag. (06:00) What the “sympathetic spiral of doom” is and how it starts. (07:00) How chronic stress and mitochondrial dysfunction feed off each other. (10:00) Why traditional lab tests often miss early warning signs of burnout. (13:00) The difference between top-down stress and bottom-up biological stress. (20:00) How being stuck in fight-or-flight impacts digestion, sleep, and muscle. (24:30) What cortisol really does to your body over time. (29:30) How supporting your mitochondria can improve sleep and reduce anxiety. Love the podcast? Here's what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you're ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/cellularhealth Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Health Optimization Medicine Podcast, join Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore the hidden cost of convenience and comfort in modern life. From ultra-processed foods and low-fiber diets to sedentary lifestyles and technology-driven comfort, the conversation dives into how convenience is quietly reshaping our biology. The HOMeHOPe Faculty explains why small daily habits — like eating whole foods, moving regularly, and embracing mild discomfort — are essential for maintaining cellular health and resilience. Rather than trying to "hack" health with quick fixes, the discussion emphasizes consistent lifestyle behaviors that support the microbiome, metabolic function, and long-term health optimization. Join us as we delve into: • Why fiber is the fastest disappearing macronutrient in modern diets • The role of gut microbiota and short-chain fatty acids in health • Why habits like sleep, eating, and exercise cannot be "banked" • The physiological consequences of ultra-convenient lifestyles • Practical ways to introduce beneficial stress back into daily life This episode is for you if: • You want to understand how convenience affects human physiology • You're interested in the role of fiber and gut health in disease prevention • You want practical ways to improve resilience and metabolic health • You're curious about the philosophy behind Health Optimization Medicine You can also find this episode on… YouTube: https://youtu.be/6wLPUuLQgcY Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/ Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/
Once I started to connect the dots that the sympathetic nervous system plays a prominent role in food impulses and behaviors, I began teaching everyone I work with how to identify when their sympathetic nervous system is activated. This isn't something we're often taught as a kid and would be a game changer to learn earlier on in life. You may just be learning this language of your body and nervous system now though and feel exhausted from living in sympathetic nervous system dominance. And your bodily depletion makes so much sense. In this week's episode, I chat with Dr. Scott Sherr, Board Certified Internal Medicine Physician, about: Understanding the sympathetic nervous system The Sympathetic Spiral of DoomMitochondrial health and its impactThe connection between trauma and eating behaviorsIntegrating nutrition in trauma workAddressing long term health challengesPractical steps to support your mitochondrial health for improved regulation and metabolic signalingYou can also read the transcript to this week's episode here: https://www.stephaniemara.com/blog/get-unstuck-from-a-sympathetic-statePlease remember that your food behaviors can be bodily communication of your nervous system state. If you have any insights from this episode, email me anytime, and talk to you more soon! With Compassion and Empathy, Stephanie Mara FoxKeep in touch with Dr. Scott:Instagram: https://www.instagram.com/drscottsherr/Instagram: https://www.instagram.com/troscriptions/ Instagram: https://www.instagram.com/onebasehealth/YouTube: https://www.youtube.com/@troscriptions Website: https://drscottsherr.com/Support the showKeep in touch with Stephanie Mara:Instagram: https://www.instagram.com/_stephaniemara/Facebook: https://www.facebook.com/stephaniemarafoxWebsite: https://www.stephaniemara.com/https://www.somaticeating.com/Linkedin: https://www.linkedin.com/in/stephmara/TikTok: https://www.tiktok.com/@stephaniemarafoxContact: support@stephaniemara.comSupport the show:Become a supporter: https://www.buzzsprout.com/809987/supportAll affiliate links: https://www.stephaniemara.com/resourcesReceive 15% off my fave protein powder with code STEPHANIEMARA at checkout here: https://www.equipfoods.com/STEPHANIEMARAUse my Amazon Affiliate link when shopping on Amazon: https://amzn.to/448IyPl Special thanks to Bendsound for the music in this episode. www.benso...
Ever feel tired & anxious even when your labs look “normal”? Dr. Scott Sher explains how mitochondrial dysfunction & metabolomics reveal what's really happening at the cellular level & why optimizing your mitochondria changes energy, focus, & resilience. Meet our guest Dr. Scott Sherr is an integrative hyperbaric medicine specialist and co-founder of Troscriptions, the company behind the first commercial pharmaceutical-grade methylene blue product. He provides worldwide hyperbaric consultation, education, and advocacy. With nearly 6 years of clinical experience using methylene blue troches, he has developed protocols bridging mitochondrial dysfunction and nervous system recalibration. Dr. Sherr also co-founded Health Optimization Medicine and Practice (HOMe/HOPe), a nonprofit training clinicians in a 7-module framework for cellular health optimization. He is the founder of OneBase Health, developing next-generation sensor and app technology for health monitoring. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Your body operates as a holobiont—an ecosystem of human cells & microbes. True optimization requires influencing the entire internal network Data driven personalization beats influencer hype. Use targeted labs to build & adjust your own supplement stack over time Every organ system depends on cellular function. Optimize cells first before pursuing advanced protocols Metabolomics provides real time snapshots of unique biochemistry, guiding interventions based on actual needs Aim for optimal young adult biomarker ranges instead of settling for average aging norms Mitochondrial capacity drives cognition, recovery, & disease resistance. Most chronic issues trace back to energy dysfunction Chronic sympathetic activation locks the body in survival mode, draining cellular reserves & accelerating breakdown Short term mitochondrial support & stress downregulation create space for sustainable long term lifestyle upgrades Balanced excitatory & inhibitory neurotransmitters like GABA & glutamate support mood stability, anxiety regulation, & recovery Deep parasympathetic recovery unlocks greater cognitive & athletic return than constant stimulation or overwork Episode highlights 01:01 Holobiont concept: Why Dr. Sherr reframes biohacking as “biont hacking” 06:01 Sympathetic spiral of doom: How chronic fight-or-flight drains mitochondria 14:04 HRV as a nervous system barometer 21:25 Mitochondria beyond the textbook 41:00 Five root causes of mitochondrial dysfunction 48:50 Methylene blue as a mitochondrial bridge 50:58 GABA-glutamate imbalance in brain signaling 53:26 Obligatory pairs for GABA support 01:07:37 The parasympathetic edge for performance & recovery Links Watch it on YouTube: https://youtu.be/SImTojIu2aY Full episode show notes: outliyr.com/252 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick
In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the core philosophical framework behind Health Optimization Medicine. Dr. Scott Sherr, Boomer Anderson, and Dr. Allen Bookatz break down the three fundamental perspective shifts that redefine how we think about health, disease, aging, and the human body itself. Rather than focusing on disease management, this episode introduces the foundational principles behind building health from the cellular level up. Join us as we delve into: • The shift from pathogenesis (studying disease) to salutogenesis (creating health) • Why longevity alone isn't enough without vitality and morbidity compression • How neotenization focuses on restoring youthful biological function • The concept of the holobiont: humans as ecosystems of interconnected organisms This episode is for you if: • You want to understand the philosophy behind Health Optimization Medicine • You're curious why modern healthcare focuses on disease instead of health • You're interested in metabolomics, cellular health, and systems biology • You want a deeper framework for longevity, vitality, and resilience You can also find this episode on… Youtube: https://youtu.be/wuCXmT783_o Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/ Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/
I am delighted to reconnect with Dr. Scott Sherr today. In our conversation, we explore the sympathetic spiral of doom that middle-aged women often experience during a pivotal time of life marked by constant shifts in mitochondrial health, hormones, and neurotransmitters. We explore what it is and how to reframe it, and offer advice on navigating that stage of life and setting the tone for the decades to follow. Join us for an empowering discussion where we share practical strategies to interrupt the spiral, reset your nervous system, avoid burnout, and shape the trajectory of your future. IN THIS EPISODE, YOU WILL LEARN: Why the intense practices promoted by wellness trends are not advisable for stressed-out individuals The importance of having a flexible nervous system that can rise under stress and return to parasympathetic calm How calming the nervous system improves your mental clarity, focus, and decision-making ability Many stress reactions may be more about how we respond than the actual event that occurred The value of doing micro-resets to regulate your emotions quickly How sighing, prolonged exhales, humming, and gargling stimulate the vagus nerve and strengthen the parasympathetic system Sleep is essential for supporting mitochondrial function, mood, and the ability to handle stress Fight-or-flight mode may damage your cellular energy systems Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Scott Sherr On his website Troscriptions - Use promo code CYNTHIA10 for 10% off Health Optimization Medicine One Base Health Previous Episodes with Cynthia Thurlow and Dr. Scott Sherr Calm, Clear, & Balanced: How GABA & Progesterone Unlock Stress Relief & Hormone Harmony | S. Sherr The Future of Healing: HBOT, Methylene Blue & Cellular Regeneration | Dr. Scott Sherr
In this episode of the Smarter Not Harder Podcast, Dr. Helen Messier joins Dr. Scott Sherr for a wide-ranging and thought-provoking conversation about longevity, epigenetics, AI-powered medicine, and the real meaning of healthspan. From whole genome sequencing to digital twins and emotional resilience, this episode bridges cutting-edge science with deeply human healing in a way that challenges how we think about aging. Join us as we delve into: The difference between lifespan and healthspan — and why resilience matters more than years Whole genome sequencing, polygenic risk scores, and the limits of genetic hype Multi-omics medicine: genomics, metabolomics, proteomics, and systems biology AI in healthcare, digital twins, and the return of the "country doctor" model This episode is for you if: You're curious about biological age vs. chronological age You want to understand what genetic testing can (and can't) tell you You're fascinated by AI's role in the future of personalized medicine You want smarter, not harder ways to build resilience and optimize longevity You can also find this episode on… Youtube: https://youtu.be/QQ-kIH3XbF0 Learn more about Dr. Helen Messier: Fountain Life: https://www.fountainlife.com/ Instagram: https://www.instagram.com/fountainlife/ Website: https://www.ifm.org/educator/helen-messier LinkedIn: https://www.linkedin.com/in/helen-messier-phd-md/ Find more from Smarter Not Harder: Website: Smarter Not Harder Podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.
Chronic stress isn't just a mental or emotional burden. It creates a biological cascade that disrupts mitochondrial function, accelerates inflammation, and shows up visibly in the skin long before deeper symptoms appear.We dive deeper into this in the Biohacking Beauty Podcast with Dr. Scott Sherr. We also talk about the sympathetic spiral of doom, why skin reflects mitochondrial decline before other symptoms appear, and why sequencing interventions matter more than intensity.Dr. Scott Sherr is a board-certified internal medicine physician certified in Health Optimization Medicine (HOMe) and a specialist in Hyperbaric Oxygen Therapy. He is the COO of Troscriptions and focuses clinically on mitochondrial health, stress physiology, and advanced recovery protocols.What's Discussed:(01:52) Why chronic stress is not just mental and directly impacts cellular energy(05:17) How modern life keeps the nervous system stuck in chronic fight or flight(07:25) Cortisol and stress hormones disrupting mitochondria and accelerating skin aging(11:16) Why skin aging is often the first visible sign of mitochondrial decline(24:16) The sympathetic spiral of doom explained through energy loss and stress signaling(27:14) Why stress reduction and mitochondrial support must happen at the same time(46:22) Why aggressive skincare and biohacking fail without mitochondrial resilience(50:35) Hyperbaric oxygen therapy, sequencing, and why timing matters more than intensityFind more from Young Goose:The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change The Winter Skin Protocol → Build for How Skin Actually Behaves in Winter VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Dr. Scott Sherr:Website: https://troscriptions.comLinkedIn: @troscriptionsInstagram: @drscottsherr @troscriptionsFacebook: @TroscriptionsYoutube: @troscriptionsTiktok: @troscriptions
The Perfect Stool Understanding and Healing the Gut Microbiome
Learn about the benefits of Methylene Blue for mitochondrial health and how this unique compound helps clear brain fog, supports SIBO recovery and provides the "energy bridge" your body needs to heal with Scott Sherr, MD. We also cover how to calm your nervous system to move from "fight or flight" into deep restoration and practitioner-grade supplements for sleep and more from Troscriptions. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, Instagram, Pinterest, Mastodon or X, or reach her via email at lindsey@highdeserthealthcoaching.com to set up your free 30-minute Gut Healing Breakthrough Session. Show Notes
Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRG and save up to 39% off your Mitopure® Gummies. → Puori | Go to https://puori.com/DRG and use the code DRG at checkout to get 32% off your first Puori Creatine+ subscription order. → My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description Your body isn't broken. It's stuck — and there's a very specific reason why. 94% of U.S. adults have some degree of mitochondrial dysfunction. That means the majority of people walking around right now can't make energy efficiently — and they're using caffeine, stimulants, and willpower to paper over it. Dr. Scott Sherr has spent over a decade figuring out why, and more importantly, how to actually fix it. Board-certified in internal medicine and one of the leading voices in health optimization medicine, Dr. Sherr introduces one of the most important concepts Dr. G has heard in a long time: the sympathetic spiral of doom — the feedback loop between chronic stress and mitochondrial breakdown that keeps you wired, exhausted, and unable to heal no matter what you try. In this episode, you'll discover: • Why more caffeine, more supplements, and more biohacks are making the spiral worse — and what to do instead • The GABA system: why depression and anxiety may have nothing to do with serotonin, and everything to do with your brain's brakes failing • The leaky gut → leaky brain connection most doctors have never heard of • How methylene blue works at the mitochondrial level — and why dose and source matter more than you think • What it actually means to optimize your health back to the resilience of your 20s — at any age If you've seen 10 doctors, tried every supplement, and still feel like you can't recover — this episode is the missing piece. Find Dr Sherr: Website: https://www.hyperbaricmedicalsolutions.com/integrative-hbot/scott-sherr Instagram: https://www.instagram.com/drscottsherr Timestamps: 0:00 - Introduction 0:35 - Rapid Fire Q&A: Caffeine, Methylene Blue & Mitochondria 2:05 - Dr. Scott's Background: From Hospitalist to Health Optimization 8:50 - What Is Health Optimization Medicine? (Ages 21–30 Blueprint) 16:20 - The Sympathetic Spiral of Doom Explained 24:30 - Signs You're Stuck in Fight-or-Flight Mode 33:00 - The GABA System: Why Supplements Don't Cross the Blood-Brain Barrier 43:57 - Methylene Blue Deep Dive: How It Works & Who It's For 51:17 - How to Shop for Methylene Blue (Quality & Dosing Guide) 56:29 - Dr. Scott's Personal Routine for Mitochondria & Nervous System Learn more about your ad choices. Visit megaphone.fm/adchoices
Are you successful but secretly running on empty? Most high-performing men are chasing success while feeling isolated, overworked, and physically deteriorating—and they don't even realize it. In this masterclass, I sit down with Dr. Scott Sherr, a board-certified internal medicine physician and health optimization expert, to dismantle the "Success Lie" that is leading men to burnout. We dive into the biological "Warrior to Wizard" transition and how to optimize your cellular architecture so you can win at work without losing at home. Troscriptions Website: https://troscriptions.com/modernman STOP GUESSING. START LEADING. Take the "Where Did My Time Go?" Audit now to identify your time leaks and reclaim 10-20 hours of your week: https://themodernmanpodcast.com/wheredidmytimego What You Will Learn In This Masterclass: The Sympathetic Spiral of Doom: Why staying in "fight or flight" mode leads to mitochondrial suicide and chronic disease. Warrior vs. Wizard: How the biological definition of strength must change as you lead a business and family. The "Normal" Trap: Why the standard medical definition of "normal" is actually a dangerous baseline for a high-performing man. Cognitive Edge: The truth about Methylene Blue and low-dose nootropics for bypassing brain fog and entering flow state. GABA vs. Serotonin: Why your "anxiety" is likely a braking-system issue, not a happiness issue. CHAPTERS 00:00 – The "Normal = Deteriorating" Trap 02:11 – The Warrior to Wizard Transition (Parenting & Control) 05:58 – Signs Your Nervous System is Crashing 08:56 – Why High-Performance Men Shouldn't Want to be "Normal" 11:17 – Mitochondria: The Engine of Executive Focus 14:27 – The Truth About Trauma Center "Health" 17:22 – The Sympathetic Spiral of Doom Explained 22:31 – How ATP Deficiency Destroys Decision Making 28:46 – Methylene Blue: A Battery Charger for the Brain 40:31 – The GABA Solution for Calm in the Storm 45:26 – Breaking the Spiral: Actionable Routines 50:23 – Identity Beyond the Title (Fatherhood & Legacy) ABOUT DR. SCOTT SHERR: Dr. Scott Sherr is a board-certified internal medicine physician specializing in Health Optimization Medicine (HOMe). He is the COO of Troscriptions and a lead faculty member of the HOMe-HOPe nonprofit, where he translates complex biochemical mechanics into actionable protocols for high-stakes performance. Sherr's Links: Website: https://drscottsherr.com/ https://homehope.org/ Instagram: drscottsherr Free eBook Here: Mastering Self-Development: Strategies of the New Masculine: https://rebrand.ly/m2ebook ⚔️JOIN THE NOBLE KNIGHTS MASTERMIND⚔️ https://themodernmanpodcast.com/thenobleknights
In this episode of the Smarter Not Harder Podcast, Dr. Linda Kiley joins Dr. Scott Sherr for a groundbreaking conversation on functional urogynecology — exploring the real causes of pelvic and bladder pain that most conventional models miss. Dr. Kiley shares how she uses muscle exams, peptide protocols, and root-cause diagnostics to treat conditions like interstitial cystitis, chronic UTIs, pelvic floor dysfunction, and endometriosis — often without surgery or long-term antibiotics. If you or someone you love has been told "there's nothing wrong" but still struggles with pelvic discomfort, bladder issues, or sexual pain, this episode is a must-listen. Join us as we explore: • The pelvic floor as a dynamic system — not just "tight or weak" • Biofilms, interstitial cystitis, and smart testing for chronic infections • How gut health and systemic inflammation drive pelvic pain • Natural, non-invasive approaches to bladder and pelvic restoration This episode is for you if: • You experience chronic UTIs, bladder discomfort, or pelvic pain • You've been dismissed or misdiagnosed by conventional providers • You're a clinician seeking better diagnostics for pelvic dysfunction • You want to understand how muscle tone, breathing, and biofilms intersect You can also find this episode on… YouTube: https://youtu.be/S0i5vKoLfEk Find more from Dr. Linda Kiley: Website: https://drlindakiley.com/ Instagram: https://www.instagram.com/drkileyurogyn/ YouTube: https://www.youtube.com/@theholisticurogynecologist3891 LinkedIn: https://www.linkedin.com/in/linda-kiley-5999462b/ More from Smarter Not Harder: Website: Smarter Not Harder podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.
In this episode of the Evolving Wellness Podcast, host Sarah Kleiner welcomes back Dr. Scott to discuss the 'sympathetic spiral of doom' and how modern lifestyles contribute to chronic stress and energy depletion. Dr. Scott shares insights into how overstimulation, poor diet, and interrupted sleep cycles can lead to nervous system dysregulation and mitochondrial dysfunction. The conversation covers the importance of circadian rhythm, hydration, and low-hanging fruit lifestyle changes to support overall wellbeing. They also explore the potential benefits of methylene blue, red light therapy, and other practical tools for regaining optimal health. Tune in to learn more about foundational steps to improve energy levels and break free from chronic stress.About Dr. ScottDr. Scott Sherr is a Board-Certified Internal Medicine Physician Certified to Practice Health Optimization Medicine (HOMe), a specialist in Hyperbaric Oxygen Therapy (HBOT), and COO of Troscriptions (a Smarter Not Harder company). His clinical telepractice includes HOMe as its foundation alongside an integrative approach to HBOT that includes cutting edge and dynamic HBOT protocols, comprehensive testing (using the HOMe framework), targeted supplementation, personal practices, synergistic technologies (new, ancient, psychedelic), and moreConnect with Dr. Scott - https://www.linkedin.com/in/drsherr/ _________Sponsored By:→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide.→ VivaRays | This episode is sponsored by VivaRays - VivaRays Blue - code YOGI https://vivarays.com/ → Organifi | For an exclusive offer, go to https://www.organifi.com/SARAHK for 20% off your order._________Timestamp:00:00 Introduction and Personal Experience with Coffee00:51 Welcome to the Evolving Wellness Podcast03:37 Understanding the Sympathetic Spiral of Doom06:29 The Role of the Nervous System and Mitochondria10:53 Practical Tips for Nervous System Regulation16:53 The Importance of Circadian Rhythm and Light Exposure25:31 Supporting Mitochondrial Health and Energy Production36:17 The State of Metabolic Health in the US36:55 Improving Mitochondrial Function37:27 Addressing Trauma and Sympathetic Overdrive38:31 The Importance of a Supportive Environment40:38 Sleep and Its Impact on Health44:35 The Role of Blue Blockers and Sleep Aids48:21 Caffeine and Its Effects on the Body50:46 The Benefits of Exogenous Ketones58:56 Navigating the Sympathetic Spiral of Doom01:05:14 Final Thoughts and Resources——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) - https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free - https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
We talk with Dr. Scott Sherr rto talk health optimization from the practical to the “hold up… what?” level.We get into light and red light therapy, mitochondria and metabolism, nitric oxide (and why mouthwash can wreck it), the “toxic bucket” concept for modern exposures, EMF/5G concerns and mitigation, and why environment matters more than most people think.Then we go deeper: psychedelics, default mode network, ketamine and integration, marijuana risks for younger users, and how perspective and nervous system regulation can change the game for recovery, sleep, and performance.Special perks for our listeners below!
In this episode, we're joined by Dr. Scott Sherr to break down how the nervous system actually drives performance, recovery, sleep, and long-term health.We dive into sympathetic vs parasympathetic balance, why being overly stimulated before training can limit gains, how to down-regulate between sets and after workouts, and why many people struggle with sleep even when they “do everything right.”We also cover cortisol rhythms, late-night training, GABA, melatonin misconceptions, recovery strategies, and why optimizing health isn't about one supplement—it's about the whole system working together.Special perks for our listeners below!
94% of U.S. adults are metabolically unhealthy. In this episode, I sit down with Dr. Scott Sherr, internal medicine physician and hyperbaric oxygen therapy expert, to unpack how damaged mitochondria, toxins, mold, and chronic stress trap the body in a sympathetic “spiral of doom,” making true healing impossible. We explore why trying to calm the nervous system without cellular support can backfire, the overlooked role of GABA in mood and sleep, when hyperbaric oxygen actually helps, and practical strategies to finally shift out of survival mode, because taking care of yourself isn't selfish, it's the foundation of real health.
Oh hey y'all.I have wanted to have this conversation for a long time, and Dr. Scott Sherr absolutely delivered.We get into what mitochondria actually do, why almost all of us are dealing with some level of dysfunction, and how energy production sits at the center of mental clarity, recovery, stress resilience, and overall health.This is one of those episodes that completely shifts how you think about your body.We also talk about methylene blue, why the internet both loves and fears it, and how to think about nervous system training, oxygen therapy, and health optimization without getting overwhelmed.This one is science heavy but incredibly practical, and honestly, I did not want it to end.Highlights:(03:09) Why mitochondria might be the missing link in modern health(09:08) The real reasons energy production breaks down over time(16:18) What health optimization medicine actually means in practice(20:30) Methylene blue explained without the hype or fear(36:25) Hyperbaric oxygen therapy, when it helps and when it does not(42:05) Building health long term while still feeling better nowConnect with Dr Scott:https://www.linkedin.com/in/drsherr/ https://www.linkedin.com/company/troscriptions/ https://www.linkedin.com/company/onebasehealth/https://www.instagram.com/troscriptions/ https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/ https://www.instagram.com/homehopeorg/Qualia Mind - click hereCoupon Code: SHOCKANDYALL (15% off any purchase)Visit Nicole's on demand fitness platform for live weekly classes and a recorded library of yoga, strength training, guided audio meditations and mobility (Kinstretch) classes, as well: https://www.sweatandstillness.comGrab Nicole's bestselling children's book and enter your email for A FREE GIFT: https://www.yolkedbook.comFind Nicole on Instagram:https://www.instagram.com/nicolesciacca/Tik Tok: https://www.tiktok.com/@thenicolesciaccaFacebook: https://www.facebook.com/nicolesciaccayoga/Youtube:https://www.youtube.com/channel/UC1X8PPWCQa2werd4unex1eAPractice yoga with Nicole in person in Santa Monica, CA at Aviator Nation Ride. Get the App to book in: https://apps.apple.com/us/app/aviator-nation-ride/id1610561929Book a discovery call or virtual assessment with Nicole here: https://www.calendly.com/nicolesciaccaThis Podcast is proudly produced by Wavemakers Audio
In this episode of the Smarter Not Harder Podcast, Ryan Carter joins Dr. Scott Sherr for a refreshingly real, honest, and grounded conversation about what's broken in the "biohacking" and health optimization world — and how to fix it. Ryan, a UK-based remote health practitioner, shares his journey from extreme protocols and burnout to balanced clinical systems that support long-term health. From redox before detox to seasonal eating, mold, light, water, and remote testing, this is the practitioner's perspective you rarely hear. Join us as we explore: • The top 5 health mistakes smart people still make • Redox before detox: why energy must come first • The dangers of extreme tribes and supplement obsession • Clinical pearls for mold, light, and remote health testing This episode is for you if: • You're overwhelmed by protocols, labs, and conflicting health advice • You've tried everything but still feel stuck or exhausted • You're a clinician building an online or remote practice • You want smarter, not harder ways to test, treat, and live You can also find this episode on…YouTube: https://youtu.be/PdkzQmQMMdU Find more from Ryan Carter: Website: https://www.livevitae.com Instagram: https://www.instagram.com/livevitae LinkedIn: https://www.linkedin.com/in/livevitae/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast?utm_source=youtube&utm_medium=video&utm_campaign=snh_podcast_guest_episode_2025_10&utm_content=podcast_asset Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% Off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase with code POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.
Dr. Scott Sherr is a Board Certified Internal Medicine Physician Certified in Hyperbaric Oxygen Therapy (HBOT) and Health Optimization Medicine (HOMe). He's a methylene blue expert. Show partners: Troscriptions - 10% off your first order by using the code "JESSE" at checkout LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Quicksilver Scientific - 15% off your first order by using the code "jesse15" at checkout Show notes: https://jessechappus.com/689
You need stress to adapt, grow and survive, but at a certain point it becomes highly toxic to your body, creating a phenomenon called a "cell danger resposne", which is a survival state where your cells stop prioritizing healing and shift into defense mode instead, because it thinks you're under threat. Even though this is designed to protect you, in today's modern world, it actually creates disease. TOPICS DISCUSSED: Why chronis stress is actually a cellular problem (not just psychological) Why trauma, toxins, infections and overtraining all land in the same biological pathway of "stress" Why even the most powerful supplements fail when your nervous system is stuck in "fight-or-flight" mode Why healing isn't about doing more, but simply teaching your body that it's safe again. More from Dr. Scott Sherr: Instagram: @drscottsherr Supplements: TroScriptions + Methylene Blue All other links, website, etc: linktr.ee/drscottsherr Leave us a Review: https://www.reversablepod.com/review Need help with your gut? Visit my website gutsolution.ca to join a program: Get help now Contact us: reversablepod.com/tips FIND ME ON SOCIAL MEDIA: Instagram Facebook YouTube
In this episode of the Smarter Not Harder Podcast, Dr. Melissa Jones joins Dr. Scott Sherr for an insightful and groundbreaking conversation about pediatric neurology, inflammation, and the integrative treatment of conditions like PANS, PANDAS, autism, and dysautonomia. Dr. Jones shares her journey from conventional pediatric neurology to functional and integrative care, breaking down how chronic infections, gut health, mold toxicity, and inflammation play a critical role in neuropsychiatric disorders in children — and how these issues can often be reversed. Join us as we explore: • What PANS and PANDAS really are — and why they're often misdiagnosed • Mold, mycoplasma, and Lyme: stealth infections affecting kids' brains • Why gut health, mitochondria, and detox pathways matter in autism • The power of lifestyle, sleep, diet, and supplements to reduce neuroinflammation This episode is for you if: • You're a parent or clinician curious about the root causes of neuropsychiatric symptoms • You're looking for integrative strategies to address autism, OCD, anxiety, and more • You want to understand how mold, toxins, and chronic infections impact kids' brains • You believe in treating the whole child — not just the symptoms You can also find this episode on… YouTube: https://youtu.be/g2HDDtQGhnQ Learn more about Dr. Melissa Jones: Website: https://aiopwellness.com/ Find more from Smarter Not Harder: Website: Smarter Not Harder podcast Instagram: https://www.instagram.com/troscriptions HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% Off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% Off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.
When fatigue lingers, it can be a sign that the body's ability to produce energy isn't functioning the way it should. Could that be what's happening in your case?. In this episode, I'm joined by Dr. Scott Sherr to explain why energy dysfunction is so common in chronic illness, and how methylene blue is being used clinically to support mitochondrial function, oxidative stress balance, and detoxification.I also explain why this topic is especially relevant for people with thyroid and autoimmune conditions, based on what I see regularly in practice. We finish by discussing nervous system regulation, GABA support, and why calming the stress response is often necessary before energy can truly improve.If you've been feeling worn down despite “doing all the right things,” this episode will help you think differently about what your body may actually need.Episode Timeline: 00:02 – Episode Introduction01:43 – Dr. Scott's Background06:26 – When Hyperbaric Helps08:59 – Hyperbaric and Chronic Illness12:51 – What Is Methylene Blue13:10 – Why Methylene Blue Helps18:04 – Why Energy Breaks Down19:09 – Detox and Antioxidant Support23:09 – Antimicrobial Effects Explained26:59 – Acute vs Chronic Dosing29:20 – Methylene Blue for UTIs32:04 – Safety and Side Effects37:33 – Thyroid and Autoimmune Support38:55 – Energy Changes in Thyroid Patients41:54 – Who Should Not Use42:16 – Product Quality Differences51:55 – Understanding the GABA System52:41 – GABA, Anxiety, and Sleep59:49 – When GABA Support Helps1:03:06 – Final Thoughts and ResourcesAbout Dr. Scott Sherr: Is a Board-Certified Internal Medicine Physician certified to Practice Health Optimization Medicine (HOMe) and a Hyperbaric Oxygen Therapy (HBOT) specialist. His clinical practice is built on HOMe as its foundation, complemented by an integrative approach to hyperbaric oxygen therapy that incorporates cutting-edge and dynamic HBOT protocols, comprehensive laboratory testing (utilizing the HOMe framework), targeted supplementation, personalized practices, synergistic technologies (both new and ancient), and more.Connect with Dr. Scott Sherr: Dr. Scott Sherr's Personal Website - https://drscottsherr.com/ Instagram - https://www.instagram.com/drscottsherr/ Transcriptions Website - https://www.instagram.com/troscriptionsInstagram - To learn more about the Hyperthyroid Healing Diet Challenge visit Savemythyroid.com/challenge2026 Free resources for your thyroid healthGet your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.comHigh-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' s Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid?Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles Watch Dr. Eric's YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos Join Dr. Eric's Graves' disease and Hashimoto's group: https://www.facebook.com/groups/saveyourthyroid Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308 Read all of Dr. Eric's published books: http://savemythyroid.com/thyroidbooks Work with Dr. Eric: https://savemythyroid.com/work-with-dr-eric/
When it comes to optimizing our entire biological systems from the ground up, where do we start? This week, Dr. Scott Sherr introduces Health Optimization Medicine, a groundbreaking clinical framework targeting cellular and gut health to restore our bodies to their optimal state. He shares how modern tests can guide personalized, data-driven interventions, and why most people are missing this foundation in both traditional and functional medicine. Whether you're a biohacker or a health practitioner, this conversation offers a completely new perspective on longevity, resilience, and feeling your best.How long will you live? Take our quiz today to find out at ageist.com/longevity-quiz!Special Thanks to Our SponsorsTimeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.LMNT Electrolytes: Our #1 electrolytes for optimal hydration. Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.Our Place: Right now, Our Place is having their biggest sale of the New Year! Save up to 35% sitewide. Head to fromourplace.com/ageist and see why more than a million people have made the switch to Our Place kitchenware. And with their 100-day risk-free trial, free shipping, and free returns, you can shop with total confidence. Shop the Our Place Holiday Sale right now (no code needed). Key Moments“There's no specialty out there that's trying to keep you healthy, to optimize your health, to find the root causes of your health.”“If your gut is not optimized, you're not gonna be optimized no matter what you try.”“The beneficial side effect of optimizing your health is that everything else will likely improve as well.”Connect with Dr. ScottHOMeHOPeInstagramConnect with AGEISTNewsletterInstagramWebsiteLinkedInClick Here for the full interview transcript.Say hi to the AGEIST team!