Podcast appearances and mentions of scott sherr

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Jup Kuipers, and Jodi Duval take a deep dive into the gut-brain-microbiota axis. Moving past the simplistic, pathogenic "pill-for-an-ill" approach of conventional psychiatry and the mainstream hype around over-the-counter probiotics, the faculty breaks down why establishing enteric safety must always precede biochemical optimization. Join us as we delve into: The Tripartite Axis: How the enteric microbiota, gut barrier, and central nervous system communicate at a molecular and metabolomic level to dictate brain state and mood. Epigenetic Signaling: How gut microbes act as active metabolic factories, fermenting dietary fibers into short-chain fatty acids (SCFAs) like butyrate that cross the blood-brain barrier to upregulate BDNF and support synaptic plasticity. The IDO Serotonin Hijack: How gut-driven inflammation activates indolamine 2,3-dioxygenase (IDO), shunting tryptophan down the kynurenine pathway to produce neurotoxic quinolinic acid instead of serotonin and melatonin. The Microglial Fire: How circulating cytokines cross the blood-brain barrier at the circumventricular organs, placing the brain's microglia into an active defense state that triggers cognitive fatigue and brain fog. The 3-Phase Gut-Brain Protocol: Why seeding probiotics into inflamed soil fails, and how to logically sequence clearing overgrowth, rebuilding mucosal integrity with L-glutamine, and seeding validated strains. This episode is for you if: You are running on high-dose over-the-counter probiotics for mood issues but feeling no relief or worsening symptoms. You want to understand the exact cellular and biochemical mechanisms connecting leaky gut to leaky brain and psychiatric distress. You want a practical, clinically sequenced blueprint to restore gut barrier safety before attempting to optimize your neurochemistry. You can also find this episode on… YouTube: https://youtu.be/A43LDN6FgvA  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Today we have Dr. Scott Sherr, an internal medicine physician who specializes in Hyperbaric Oxygen Therapy. Scott is the director of Integrative Hyperbaric Medicine and Heath Optimization at Hyperbaric Medical Solutions. It is a division of Hyperbaric Medical Solutions, an independent, hyperbaric oxygen therapy provider that aims to educate people about the benefits of hyperbaric oxygen therapy via telemedicine consulting. He also is COO of Troscriptions, which provides physician-formulated products including popular methylene blue products. In today’s interview, Scott talks about how he uses Hyperbaric Oxygen Therapy (HBOT) to treat a number of health conditions. He also shares how he incorporates methylene blue into some of his treatment strategies and explains how HBOT is now being used as a complementary treatment for autoimmune diseases by helping reduce inflammation, improve blood flow and support immune function. Show notes: [00:03:29] Dawn tells Scott that she heard a story that Scott had his spine adjusted when he was just five minutes old.  She asks Scott if he can share what happened. [00:04:15] Dawn mentions that Scott grew up in New York on Long Island and that as a child he spent a lot of time at his father's chiropractic office. Dawn asks Scott about his father and his practice. [00:05:38] Ken notes that Scott was into sports as a kid and asks him to talk about his childhood and what he was like as a kid. [00:07:09] Dawn notes that after high school, Scott left New York for the West Coast, landing at UCLA. Dawn asks Scott to talk about what led him there. [00:08:00] Dawn explains that Scott initially started to major in biology but quickly changed majors. Scott explains why he changed majors. [00:08:41] Dawn asks Scott why he chose to attend the University of Maryland for medical school after graduating from UCLA. [00:09:26] Dawn asks Scott about the story of how he met his wife at the University of Maryland. [00:09:50] Dawn pivots back to Scott's love of music, mentioning that Scott and three other medical school students at Maryland formed a band called The Airport Rocking Chairs. Scott describes how the band came together and how they performed at gigs around the Baltimore/D.C. area. [00:11:16] Ken asks Scott to talk about how his early ambition upon entering medical school was to find a way to bridge the gap between conventional and alternative/chiropractic medicine. [00:12:54] Ken explains that in Scott's third year of medical school, he did rotations at the University Shock and Trauma Facility. Ken asks Scott to talk about why this was such an important experience for Scott. [00:14:32] Dawn explains that hyperbaric chambers are used to treat injuries like necrotizing fasciitis and severe wounds. Dawn asks Scott to talk about finding a hyperbaric chamber in the basement of the University Shock and Trauma Facility and how that led to his fascination with the potential for hyperbaric oxygen therapy. [00:15:51] Dawn asks Scott to talk about how his initial research on hyperbaric therapies led him to conclude that they were being vastly underutilized in conventional medicine. [00:16:31] Dawn mentions that people are likely familiar with hyperbaric oxygen therapy (HBOT) in terms of treating divers suffering from decompression sickness. She asks Scott to give a primer on the mechanisms by which HBOT affects the body and why it has potential to treat other conditions besides decompression sickness. [00:19:38] Ken asks Scott to talk more about other conditions, both acute and chronic, that HBOT might be helpful in treating. [00:22:51] Dawn asks about Scott's experience as a hospitalist, which is an internal medicine physician who acts as a primary care physician in a hospital, and how this experience gave him a unique perspective on the strengths and limitations of modern medicine. [00:25:13] Ken asks Scott if it's fair to say that his experience as a hospitalist was foundational in developing his understanding of patient care and healthspan. [00:26:51] Dawn explains that when Scott's wife received a fellowship at Stanford University, Scott eventually left his career as a hospitalist to serve as the medical director for a hyperbaric medicine facility in the San Francisco Bay area. Dawn asks Scott to talk about how this experience deepened his understanding and expertise in hyperbaric oxygen therapy. [00:28:26] Ken asks Scott to talk about his relationship with Dominic D'Agostino, who was our recent guest on STEM-Talk episode 196, and who is very active in the field of hyperbaric oxygen therapy. [00:30:48] Dawn mentions that during Scott's work as a hospitalist, he began to develop a more integrated approach to hyperbaric medicine, taking nutritional status, sleep patterns, mitochondrial function, and a number of other factors into consideration. Doing this work, Scott noticed that a number of patients would require weeks or months of preparation before beginning HBOT, contrary to the status quo of the time. Dawn asks Scott to talk about his insights and how this experience changed his views on medicine. [00:33:19] Dawn asks Scott to talk about the evolution of his work in developing an integrative hyperbaric medicine model and how he caught the attention of HBOT practitioners around the world. [00:35:21] Ken notes that interest in hyperbaric oxygen therapy has grown substantially in the last 20 years and goes on to mention that a particularly promising application of HBOT is as a complementary treatment for autoimmune diseases, being shown to reduce inflammation, improve blood flow and support immune function. Ken asks Scott to talk in depth about HBOT in the context of autoimmune disease treatment. [00:39:13] Following up on Scott's mention of epigenetic changes following HBOT, Ken asks if this has been directly measured and if so, how long are these changes sustained. [00:41:14] Dawn asks Scott about the potential for HBOT to be used for athletes looking to speed up their recovery times from injuries. [00:43:19] Dawn asks Scott if there are certain populations who should avoid HBOT. [00:46:27] In order to optimize HBOT, Dawn explains that Scott works with people to tailor their treatment to their individual needs and asks Scott to walk listeners through how this process works in practice. [00:50:00] Ken notes that most HBOT studies describe dosages of HBOT in terms of oxygen concentration, oxygen pressure and number of sessions. He asks Scott how he defines a “dose” biologically and what metrics he uses to tell whether a patient has received enough treatment to induce durable change? [00:53:40] Ken asks Scott if his experience treating patients has informed him on different characteristics that can predict whether a patient will have a robust response to HBOT. [00:56:01] Dawn mentions that the benefits of HBOT are often explained in terms of either improved oxygen delivery or improved mitochondrial signaling and neuroplasticity. Dawn asks Scott what mechanisms are most important in the context of chronic neurological disease. [00:58:04] Dawn asks Scott for his thoughts on the hyperoxic-hypoxic paradox (HHP) as an explanation of HBOT-induced adaptation. [01:00:28] Ken asks Scott if he could only measure three variables before and after HBOT treatment, what would they be. [01:03:43] Ken goes on to asks Scott what he sees as the most important unanswered question in HBOT today. [01:06:22] Dawn mentions that in 2017 Scott met Dr. Ted Achacoso, who is the founder of Health Optimization Medicine. Dawn asks Scott to explain how Ted introduced him to a fundamentally different framework for understanding health. [01:10:08] Circling back to the topic of bridging the gap between conventional and alternative medicine, Dawn mentions that Scott has become part of a practice that isn't afraid to tap into therapies that break from conventional medicine. As an example, Dawn explains that Scott sometimes integrates psychedelic therapy with HBOT. Dawn asks Scott to talk about the framework he uses, combining HBOT with psychedelic therapy. [01:13:56] Ken mentions that Scott also incorporates methylene blue into some of his treatment strategies, Ken directs listeners interested in learning more about how methylene blue can improve cognitive function and energy production to listen to STEM-Talk episode 191 with Francisco Gonzalez-Lima. Ken asks Scott to talk about his use of methylene blue in his practice. [01:20:15] Dawn asks Scott where people can go to learn more about him and his practice. [01:22:33] Ken asks Scott if he has any new projects looming on the horizon. [01:23:54] Dawn closes our interview with Scott by asking if he still plays guitar and if his old band The Airport Rocking Chairs have any plans for a reunion. Links: Scott Sherr bio Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio  

In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma exchange and "blood washing". Moving past the mainstream marketing of plasmapheresis as a longevity cure-all, the team breaks down why mechanical filtering is only a surface-level fix for microplastic toxicity. From the autonomic anxiety caused by biological lockdown to the clinical application of precision metabolomics, this roundtable shifts the conversation from invasive procedures to measurable, cellular safety signals.   Join us as we delve into: The Protein Corona: How circulating microplastics masquerade as pathogens, triggering localized purinergic signaling and the release of extracellular ATP. The Cell Danger Response (CDR1): Why the body halts oxidative phosphorylation and locks down the cell membrane when invaded, and why blood washing can't touch toxins stuck inside tissue matrices. The Problem with Plasmapheresis: The clinical realities and physiological costs of invasive vascular filtering, including the removal of essential immunoglobulins and clotting factors. The True Detox Protocol: Utilizing organic carbon binders (humic and fulvic acids), phase two liver conjugation (glucuronidation/sulfation), and barrier integrity support to properly excrete microplastics. Pulsed Antioxidant Support: When and why to use targeted NAD, alpha-lipoic acid, NAC, and ubiquinol to transition cells out of a defensive lockdown.   This episode is for you if: You are considering expensive therapies like plasmapheresis to clear environmental toxins. You want to learn how to test your cellular metabolomics for organic acids and brain inflammation. You want to understand how your unique exposome interacts with your cellular safety mechanisms.   You can also find this episode on… YouTube: https://youtu.be/5b4jWqByRAU   Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics   Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

You've cleaned up your diet. You're taking the supplements. You're exercising, sleeping more, and doing everything "right." So why do you still feel exhausted, inflamed, anxious, or stuck? In this encore episode—one of the most impactful Office Hours conversations we've shared—I explore a question that could change the way you think about healing: What if your nervous system is the missing piece? When your body doesn't feel safe, it prioritizes survival over repair, affecting everything from your metabolism and hormones to your gut, immune system, and brain. In today's episode, I break down: Why chronic stress changes your biology—and how nervous system dysregulation can drive inflammation, hormone imbalance, digestive issues, weight gain, and autoimmune disease The difference between living in constant "fight-or-flight" versus a regulated nervous system that supports healing, resilience, and recovery Simple, science-backed strategies to regulate your nervous system, including breathwork, blood sugar balance, strength training, sleep, and daily safety cues Why you can't out-supplement or out-biohack chronic stress—and how creating physiological safety unlocks your body's natural ability to heal Healing isn't just about finding the right supplement or following the perfect diet. It's about creating an environment where your body feels safe enough to repair itself. When you begin working with your nervous system instead of against it, everything else—from your energy and metabolism to your mood and resilience—can start to change. Check out my full conversation with Dr. Scott Sherr HERE. Track your health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.) Have a question you'd love answered on Office Hours? Submit it here Resources Mentioned: Listen to my full conversation with Dr. Scott Sherr on nervous system regulation and mitochondrial health.

Today, I'm delighted to share a compilation of adrenal-centric discussions with experts Drs. Sonya Jensen, Carrie Jones, Scott Sherr, and Will Bulsiewicz, and geneticist Dr. Yael Joffe, Nurse Practitioner Heather Quaile, and Physician's Assistant McCall McPherson. In this masterclass, we explore the effects of generational silence and how the thrifty genotype impacts the likelihood of poor metabolic health outcomes over time. We define the GABAergic system and the effects of decreased progesterone in perimenopause, and examine how our immune and nervous systems are impacted in midlife. We discuss the impact of GABA cofactors, the connection between adrenal and thyroid health, how stress affects ovarian aging, and the impact of genetics on our lifestyle choices and responses. We also unpack shift work and circadian rhythm disruption, and their influence on the gut microbiome. Join us for today's action - and information-packed, adrenal-centric podcast. I know you will enjoy listening to it as much as I enjoyed putting it all together. IN THIS EPISODE, YOU WILL LEARN: The impact of generational trauma on stress resilience and metabolic health across generations How famine exposure, family history, and cultural background could contribute to our metabolic and hormonal health How estrogen metabolism pathways can influence hormone balance and long-term health The importance of B vitamins, magnesium, amino acids, protein, and overall nutritional status for healthy liver function and detoxification How ongoing fight-or-flight activation can impair energy production and contribute to a cycle of worsening stress and fatigue How hormones, sleep, toxins, infections, and insulin resistance can influence mitochondrial performance The importance of optimizing thyroid and adrenal dysfunction together  How chronic stress and adverse childhood experiences can influence ovarian aging  How gut barrier dysfunction can contribute to chronic low-grade inflammation How genetics and epigenetics can affect our appetite, hormone metabolism, mood, and treatment responses Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Sonya Jensen On her book website: Heal Your Hormones, Reclaim Yourself Instagram Connect with Dr. Carrie Jones On Instagram Estrogen Detox Made Easy Hello Hormones with Dr. Carrie Jones - Podcast Connect with Dr. Scott Sherr On his ⁠website⁠ Troscriptions ⁠Health Optimization Medicine   One Base Health⁠⁠ Connect with McCall McPherson On Modern Thyroid Clinic Instagram and TikTok Modern Thyroid and Wellness Podcast Thyroid Lab Guide Connect with Heather Quaile On her website  Instagram Connect with Dr. Will Bulsiewicz On his website Connect with Yael Joffe On 3X4 Genetics Instagram Facebook Podcast Links: Ep. 559 Heal Your Hormones, Reclaim Yourself: Women's Health in Midlife with Dr. Sonya Jensen | Perimenopause, Menopause & Hormones Ep. 567 “Timing Is Everything” – The Best Way to Test Hormones, Cortisol & Thyroid for Real Answers with Dr. Carrie Jones BONUS: "The Sympathetic Spiral of Doom!” – The Fastest Way To Reset Your Nervous System & End Burnout with Dr. Scott Sherr Ep. 478 Thyroid Truths: Labs, Adrenals & Appetite Explained with McCall McPherson Ep. 498 Chronic Stress Is Aging Your Ovaries – The Shocking Link Between Trauma, Hormones & Menopause with Heather Quaile Ep. 537 The #1 Longevity Nutrient You're Missing – How Fiber Supercharges Your Gut, Immunity & Sleep with Dr. Will Bulsiewicz Ep. 558 Your DNA Isn't Your Destiny – The Most Actionable Way to Use Genetics for Weight Loss with Dr. Yael Joffe

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern biohacking: sleep tracking. Moving past the mainstream obsession with daily device scores, the team breaks down the biochemical realities of how tracking your HRV might actually be sabotaging your sleep architecture. From the autonomic anxiety caused by digital wearables to the clinical application of precision chronobiology, this roundtable shifts the conversation from algorithmic scores to measurable, cellular safety signals. Join us as we delve into: The Orthosomnia Epidemic: Why waking up to a red recovery score immediately triggers your prefrontal cortex, activates your HPA axis, and flattens your diurnal cortisol curve. The HRV Paradox: Understanding the actual biological markers of Heart Rate Variability and why an algorithmic score doesn't dictate your physical reality. The Cell Danger Response: How the body is only able to sleep when it feels safe, and why the ultimate "detox" might just be a sleep divorce. Your "Do This on Monday" Protocol: Dr. Ted's clinical sleep anchoring technique, and why prioritizing sleep as the first activity of your day changes your entire circadian rhythm. Precision Cellular Nutrients: The clinical difference between taking generic sedatives and utilizing precision magnesium, glycine, and even strategic carbohydrates (like honey) to optimize GABA and melatonin. This episode is for you if: You are experiencing worsening sleep anxiety and chronic insomnia despite meticulously tracking your data every night. You want to learn how to test your cellular metabolomics for brain inflammation instead of relying on a generic smartwatch algorithm. You want to understand how your unique chronobiology dictates your sympathetic and parasympathetic balance. You can also find this episode on… YouTube: https://youtu.be/n71oG96M1Ek Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Dr. Scott Sherr is an Internal Medicine Physician certified in Health Optimization Medicine (HOMe), a hyperbaric oxygen therapy (HBOT) expert with over a decade of clinical experience, and the COO of Troscriptions, a company that creates precision-dosed buccal troches with cutting-edge ingredients, including methylene blue and GABA modulators.

In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern nutrition: fiber. Moving past the mainstream trend of "fiber-maxing," the team breaks down the actual biochemical realities of how different forms of fiber interact with your unique gut microbiome. From the surprising hormonal impacts of over-consuming fiber to the rise of localized conditions, this roundtable shifts the conversation from generic dietary rules to precise, measurable, cellular data. Join us as we delve into: The Classification of Fiber: Understanding the biological differences between soluble fiber (which breaks down into calories) and insoluble fiber (which adds bulk to stool). The Fiber Maxing Trap: Why forcing massive amounts of psyllium husk, acacia powder, and green drinks can aggravate conditions like Small Intestinal Bacterial Overgrowth (SIBO) and IBS. The Estrogen Heist: The hidden clinical correlation between high-fiber diets (60g+ per day) and the cessation of menstruation (amenorrhea) in female athletes. Short-Chain Fatty Acids (SCFAs): The crucial roles of propionate, acetate, and butyrate as genetic signalers and the primary fuel source for your large intestine. The Gut as an Immune Organ: Why managing the "gut-associated lymphoid tissue" (GALT) forms the basis of roughly 80% of human immune system function. This episode is for you if: You are experiencing worsening gas, bloating, and discomfort despite eating a "clean, high-fiber" vegetarian or whole-food diet. You want to learn how to test your stool for real-time butyrate levels instead of relying on generic probiotic protocols. You want to understand how your unique gut ecosystem mirrors a complex, balancing rainforest. You can also find this episode on… YouTube:  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

Are you suffering from chronic "adult tiredness," or wondering why you immediately get sick the second you finally go on vacation? In this episode of Beauty Bytes, I am joined by Dr. Scott Sherr, a board-certified internal medicine physician, specialist in hyperbaric oxygen therapy, and leader in health optimization medicine. We are doing a massive deep dive into the true powerhouse of your cells: the mitochondria. With only 6% of the US population having optimized mitochondrial function, it is no wonder so many of us are completely exhausted. Dr. Sherr explains why the traditional approach to feeling better is backward, revealing why you must fix your cellular energy before trying to lower your stress and anxiety. We also talk about a fascinating synthetic compound called methylene blue. Dr. Sherr explores how taking it via buccal troches can hack jet lag, eliminate brain fog, and safely jumpstart your biological system. Plus, we cover the real science of hyperbaric oxygen therapy and why your skin is actually your "reverse gut".Guest Information: Dr. Scott Sherr is the Chief Medical Officer of Troscriptions and One Base Health. You can find his products at troscriptions.com and learn more about his health optimization practice at drscottsherr.com.

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears. Join us as we delve into: •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology. •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly. •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture. •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress. •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end. This episode is for you if: •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work. •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers. •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint. You can also find this episode on… YouTube: https://youtu.be/DygsezbmZxM  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

In this episode, Leigh Ann welcomes Dr. Scott Sherr, co-founder of Troscriptions, for a conversation on GABA, anxiety, stress, sleep, and fast-acting nervous system support. Dr. Sherr shares how his background in internal medicine, hyperbaric oxygen therapy, and health optimization medicine led him to help create products designed to support people while they are on a longer healing journey. He explains why many people may be struggling with GABA deficiency, how chronic stress can deplete the body's calming pathways, and why anxiety, insomnia, racing thoughts, and low energy are often interconnected. Leigh Ann and Dr. Sherr discuss the unique buccal troche delivery method, how it differs from capsules and sublingual supplements, and why it can allow for faster absorption and more flexible dosing. The conversation also explores TroCalm, Trozy, alcohol's impact on the GABA-glutamate balance, sleep architecture, and why calming the nervous system does not have to mean feeling sedated.Product Discount Codes + LinksHoolest: Website (Discount Code: THEACCRESCENT10)Froya Hair Care: Website (Link gives 10% off)Herbal Face Food: Website (Discount Code: LAL30)Episode LinksTroscriptions - Website (Discount Code: LEIGHANN)Guest InfoDr. Scott Sherr - WebsiteRelated EpisodesPodcast Ep. 203: Anna Finck - Reconnecting to Our Bodies, Reclaiming Our Health, and Remembering Our PowerPodcast Ep. 150: Michael Byrne - The Bia Smart Sleep MaskWork w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Healing Alchemy MembershipConnect w/Me & Learn MoreWebsiteInstagramTiktokYoutube

If you've been doing everything right and still feel exhausted, anxious, and like your body just won't cooperate — this episode is for you. I sat down with Dr. Scott Sherr, a board-certified internal medicine physician and COO of Troscriptions, to talk about the sympathetic spiral: a chronic fight-or-flight loop most people don't even know they're in. And here's what surprised me most — you don't have to feel stressed to be stuck in it. We get into why your cellular energy and your anxiety are locked in a loop, what mitochondrial dysfunction actually means for your daily life, and how a specific sequence of support can help you finally start feeling better. We also go deep on methylene blue — the history, how it works, the right dosing range, and the sourcing and safety details that most people skip (including who should absolutely not use it). Plus: why GABA deficiency is so common, how to calm your nervous system without sedating yourself, and why sleep is a full-day practice — not just a bedtime routine. For the complete show notes, links and transcripts, visit inspiredliving.show/247

Hyperbaric oxygen therapy or HBOT is one of the most scientifically validated yet underutilized treatments in modern medicine. And Dr. Scott Sherr has spent his career proving exactly why. In this episode, Dr. Sherr board certified internal medicine physician, hyperbaric oxygen specialist, and COO of Troscriptions breaks down everything you need to know about HBOT: how it works at the cellular level, which conditions it treats, how to access it, and how to combine it with cutting-edge molecules like methylene blue for maximum results. Whether you're dealing with brain fog, chronic fatigue, long COVID, TBI, or simply want to optimize your health and slow down aging this episode is for you.

In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty, they dive deep into the specific biology of preconception, pregnancy, and pediatric health optimization. Moving beyond typical disease management, they explore how to foster both psychological and cellular safety across the entire family unit. Join us as we delve into: The Masterclass Blueprint: Navigating the fastest period of human growth and biological wiring from preconception to age 12. The Energy Demands of Fertility: Why oocytes (eggs) and reproductive organs hold the highest mitochondrial density per cell in the body. Pediatric Shifts: Addressing modern rises in childhood insomnia, allergies, immune dysregulation, and pediatric autoimmunity through an exposomic lens. The Testing Trap: Why traditional adult lab testing templates aren't always required—or appropriate—for resilient, self-correcting children. Family Attunement & Nervous System Regulation: Understanding why adult parent optimization directly dictates child behavior, sleep quality, and home environment stressors. This episode is for you if: You are a parent looking to leverage practical bioenergetics, chronobiology, and clean exposomics for your household. You are preparing for pregnancy and want to optimize cellular health during the critical 90-day preconception timeline. Your child is struggling with modern issues like appetite dysregulation, blue-light toxicity, or environmental heavy metal burden. You want a sustainable template for family health that values parent self-care over self-sacrifice. You can also find this episode on… YouTube: https://youtu.be/WsvoFXcIuZ4 Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics  Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

If you're eating well, exercising, taking supplements, and still don't feel like yourself, your nervous system may be stuck in survival mode. Most people assume low energy means they need more discipline, another supplement, or the latest health hack. But what if the real problem isn't effort at all? Studies estimate that over 70% of primary care visits are linked to stress-related disorders. At the same time, mitochondrial dysfunction is increasingly recognized as a contributor to fatigue, poor recovery, and reduced resilience.  In this episode of Uncover Your Eyes, Dr. Meenal Agarwal sits down with Dr. Scott Sherr, a Physician who specializes in health optimization medicine. They explore the connection between chronic stress, nervous system dysregulation, and cellular energy production. Together, they discuss hyperbaric oxygen therapy, methylene blue, and practical strategies to improve recovery and performance.  In this episode, you'll uncover:

Our trusted source for Methylene Blue: https://www.troscriptions.com/muscle (10% off) Functional medicine Dr. Scott Sherr joins Ben Pakulski to break down methylene blue — the 100-year-old compound that's become one of Ben's favorite tools for energy, focus, and endurance. Dr. Sherr explains how it reboots mitochondrial function in days (not months), how one endurance athlete he coaches cut three hours off a 100-mile race, and how to dose it safely. Plus the warning most people never hear: why the majority of methylene blue sold online is contaminated, and what to look for in a clean source. In this episode… → The bottleneck behind almost everything (energy, brain, recovery, fat loss)  → The four complexes of your electron transport chain, and where most men are blocked → Why statins might be quietly trashing the system you're trying to optimize → Which molecule does "ninja moves" for mitochondrial dysfunction → The exact dosing protocol Scott uses for performance, travel, sauna, and endurance About Dr. Sherr Dr. Scott Sherr is a board-certified Internal Medicine physician and one of the leading clinical voices on methylene blue and mitochondrial medicine. He is certified to practice Health Optimization Medicine (HOMe) — a root-cause framework he helped bring to the U.S. as founder of HOMe-SF, the country's first HOMe clinic — and is a specialist in Hyperbaric Oxygen Therapy (HBOT). He is the COO of Troscriptions (the precision-dosed troche company behind Just Blue, Tro+ Blue, and Blue Cannatine) and its parent, Smarter Not Harder, as well as COO of the nonprofit Health Optimization Medicine and Practice (HOMe/HOPe) USA, which trains doctors to detect and correct the root causes of health. He is also co-founder of OneBase Health, an integrative HBOT ecosystem. He has consulted for Upgrade Labs, Remedy Place, and other wellness ventures, and lives in Louisville, CO with his wife and four kids. Key credentials Board-Certified Internal Medicine Physician  Hyperbaric Oxygen Therapy (HBOT) specialist  COO, Troscriptions / Smarter Not Harder COO, Health Optimization Medicine & Practice (HOMe/HOPe) USA  Co-Founder, OneBase Health  Connect with Dr. Sherr Instagram: https://www.instagram.com/drscottsherr/ LinkedIn: https://www.linkedin.com/in/drsherr Website: https://drscottsherr.com/ Work with Muscle Intelligence The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply/ If you're interested in working with Ben. ben@muscleintelligence.com Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter

We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling. In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions. This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition. If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on. In this episode, we cover: Why brain fog is such a common midlife complaint What mitochondria actually are and why they matter for brain energy How estrogen loss may contribute to mitochondrial dysfunction How methylene blue may support mitochondria, energy production, and mental clarity The difference between low-dose and high-dose methylene blue use The truth about methylene blue and nitric oxide Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain How stress and sympathetic overload affect mood, sleep, and focus Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support Why HRT may help, but may not be the whole story for every woman Who this episode is for This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms.   Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He's the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients. Troscriptions: Use coupon code HORMONE for 10% off your order.     Sponsors Get 15% off Masszymes at bioptimizers.com/hormone  Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back!  Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system.

There is a state where the body gets locked in sympathetic activation and mitochondrial dysfunction at the same time and no matter what supplements you take, no matter what protocols you run, nothing actually works. Dr. Scott Sherr calls it the sympathetic spiral of doom, and in this episode we break down exactly what it is, why so many people are stuck in it without knowing it, and the right sequence to actually get out.Dr. Scott is a board certified internal medicine physician, certified in hyperbaric oxygen therapy and health optimization medicine, and the chief medical officer of One Base Health, the company behind the hyperbaric chamber you see in every episode. He advises me personally on my hyperbaric protocols, including the ovarian longevity protocol I have been running, and this conversation goes deep into the science behind why that protocol makes sense and what we are actually trying to achieve.This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off.⁠https://zenbasil.com/shopzenbasil/zenbasilseedbag⁠Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityExplore Troscriptions' mitochondrial, immune, and nervous system support products. Use code KAYLA10 at checkout for 10% off.https://troscriptions.comIn This Conversation:- Why Autoimmunity Risk Rises In Women During Perimenopause - Why The Body Can't Heal When Stuck In Stress Mode- How Chronic Stress And Social Media Can Reduce Recovery Capacity- What Methylene Blue Does- Why The Gaba System Matters- When Hyperbaric Therapy HelpsConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Scott Sherr and his work:Websites:drscottsherr.comhomehope.orgonebasehealth.comTroscriptions.comInstagram:https://www.instagram.com/troscriptions/https://www.instagram.com/drscottsherr/https://www.instagram.com/onebasehealth/https://www.instagram.com/homehopeorg/Youtube:https://www.youtube.com/@troscriptionshttps://www.youtube.com/@drscottsherrLinkedIn:https://www.linkedin.com/in/drsherr/https://www.linkedin.com/company/troscriptions/https://www.linkedin.com/company/onebasehealth/

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization and the "more is better" mentality. They explore real clinical case studies of patients who inadvertently damaged their health by blindly following supplement trends. Join us as we delve into: The dangers of over-supplementing with high-dose Fish Oil and Vitamin B6. How shifting to an "Omega-3 dominant" ratio can actually hinder your immune system's ability to heal injuries. Why you should treat metabolomic testing like the dashboard of a car to prevent the "check engine light" of chronic disease. How clinical metabolomics allows you to stop guessing and start subtracting unnecessary pills from your daily routine. This episode is for you if: You are experiencing wellness burnout and taking a massive handful of supplements every day without knowing if they are working. You want to understand the difference between being "fit" (e.g., running a marathon) and being truly cellularly "healthy." You are curious about functional testing and how it differs from the standard disease-focused bloodwork at a primary care clinic. You want a clear strategy to cut through social media influencer noise and build a foundational, personalized health protocol. You can also find this episode on… YouTube: https://youtu.be/WSNOBi1e7WY  Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its reputation as just a performance supplement for "gym bros," Boomer Anderson, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Ted Achacoso break down how creatine functions as a critical cellular battery buffer. Join us as we delve into: How creatine bypasses the "methylation tax" by saving the body from depleting SAMe reserves to produce energy. Why muscle is a metabolic determinant of resilience and not just a cosmetic feature. The evolutionary mismatch that increases our cellular energy demands due to a highly sympathetic, stressed lifestyle. The role of creatine in brain health is particularly important for supporting working memory, mitigating cognitive fatigue, and protecting against excitotoxicity. This episode is for you if: You are curious about how to support your body's cellular energy and mitochondrial function. You follow a vegetarian or plant-based diet and want to understand your specific creatine supplementation needs. You want to understand the difference between maintaining muscle for aesthetic reasons versus metabolic health. You are looking for strategies to mitigate mental fatigue and sleep deprivation. You can also find this episode on... YouTube: https://youtu.be/R4x9tu56FXg  Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics  Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/  Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you've been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You're not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn't Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

In this episode of the HOMe Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz explore a foundational principle of Health Optimization Medicine: What's toxic to the cell is toxic to every organ. Through real clinical cases — including mercury toxicity, arsenic exposure, and environmental toxin accumulation — the team reveals how modern medicine often misses the root cause of disease by focusing on isolated organ systems instead of cellular function. From chronic low-level toxin exposure to acute breakdown events, this episode highlights how toxins disrupt mitochondrial energy production, leading to widespread dysfunction across the body. Most importantly, the conversation emphasizes the role of metabolomics in identifying these hidden stressors early — before they manifest as disease. Join us as we delve into: • Why toxins affect every organ through the cell • A real case of mercury toxicity missed by multiple specialists • How chronic exposure becomes acute illness • Why traditional medicine misses root causes • The role of mitochondria in energy production and health • How metabolomics detects early toxicity and dysfunction This episode is for you if: • You want to understand the root cause of chronic illness • You're exposed to environmental toxins (food, water, air) • You're interested in preventative and optimization-based medicine • You want to take a proactive approach to long-term health You can also find this episode on…Youtube: https://youtu.be/CMhFC5IUKl0 Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with JJ Virgin — nutrition expert, bestselling author, and founder of the Health Business Growth Collective — to explore how healthcare practitioners can build trust, authority, and impact in today's rapidly evolving landscape. With the rise of AI and what JJ calls a "trust recession," the traditional ways of building a practice are no longer enough. Instead, practitioners must learn how to stand out as a trusted authority — combining credibility, authenticity, and real-world proof. JJ breaks down her powerful "Trusted Authority Framework," explaining how clinicians can differentiate themselves, connect with patients, and grow their influence without becoming influencers. This episode is a must-listen for practitioners looking to grow, scale, and future-proof their practice in the age of AI. Join us as we delve into: The "Trust Recession" and why it's reshaping healthcare The difference between being an influencer vs a trusted authority Why vulnerability and storytelling build trust faster than credentials How to develop a contrarian stance that defines your expertise The power of patient stories as proof (and why they outperform credentials) Why most practitioners struggle with imposter syndrome — and how to reframe it This episode is for you if: You're a practitioner looking to grow your practice You want to build authority without becoming a social media influencer You're navigating AI, personal branding, and patient trust You want to stand out in a crowded health and wellness space You can also find this episode on… YouTube: https://youtu.be/rmyDXStM_Dk Find more from JJ Virgin Website: https://jjvirgin.com Health Business Growth Collective: https://hbgc.co Instagram: https://www.instagram.com/jj.virgin/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

What if a 150-year-old compound could still outperform modern solutions? I'm so excited to dive into the world of mitochondrial health today with Dr. Scott Sherr, a physician who specializes in health optimization and chronic illness protocols. We're exploring the fascinating history and science of methylene blue, a powerful tool that can help you reclaim your energy and support your body's natural detoxification processes. You'll learn why this "old-school" dye is hitting the zeitgeist and how to use it safely to age powerfully. What you'll learn: (00:00:11) What methylene blue is and how it was originally developed as a textile dye. (00:00:54) How methylene blue became one of the first synthetic antimicrobial drugs in history. (00:01:35) Why the “natural vs synthetic” debate can be misleading for your health decisions. (00:03:24) How methylene blue supports mitochondrial function and energy production. (00:03:59) Why you feel fatigued on airplanes and how oxygen levels impact your body. (00:04:54) Who may benefit from daily methylene blue use and who may not need it. (00:06:01) How to dose methylene blue properly for energy, stress, and performance. (00:09:04) Why supplement quality and testing are critical for safety and effectiveness. Watch the full episode: https://youtu.be/UKIJcM5zhWs?si=pR_nDOlBeL6UdWIP Full show notes (including all links mentioned): https://jjvirgin.com/hyperbarichealth Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Ted Achacoso, Dr. Scott Sherr, and Jodi Duval explore mental health through the lens of health optimization medicine. Rather than viewing mental health as a set of diagnoses, the conversation reframes it as a function of cellular health — where brain function is driven by mitochondrial performance, inflammation, nutrient status, and environmental inputs. From neurotransmitter imbalances to brain inflammation and the gut-brain-microbiome axis, this episode breaks down how modern stressors, lifestyle, and environment impact mental health at the cellular level. Most importantly, the team explains why true mental health optimization must begin with optimizing the health of the cell. Join us as we delve into: • Why mental health should be viewed at the cellular level • The role of mitochondria in brain energy and signaling • Brain inflammation and its impact on mood and cognition • The gut-brain-microbiome axis and neurotransmitter production • Why stress, sleep, and environment drive mental health outcomes This episode is for you if: • You struggle with brain fog, anxiety, or low mood • You want a deeper, root-cause understanding of mental health • You're a practitioner looking beyond traditional psychiatry • You want to optimize cognitive performance and resilience You can also find this episode on…YouTube: https://youtu.be/5xqAzkMUpBs Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Dr. Scott Sherr is a clinician, hyperbaric medicine specialist, co-founder of Troscriptions, and one of the founding faculty of the Health Optimization Medicine and Practice nonprofit — and in this return episode, he comes with a very different perspective than his first appearance. What changed? He stopped putting everyone in the chamber. In this conversation, Scott and Freddie unpack the two hyperbaric chamber deaths that shook the industry in 2025 — what actually went wrong, what safety standards clinics and home users are missing, and why a sympathetically dominant nervous system may render even the best biohacking tools completely ineffective. From there they go deep on mitochondrial function as the master upstream driver of energy, detox, digestion, healing, and longevity — and why most people need to subtractbefore they can optimize. The second half of this episode is a complete masterclass on methylene blue — what it actually does at the mitochondrial level, how to find your ideal dose (hint: you'll know within three to five days), why 94% of American adults are metabolically compromised enough to benefit from it, and how one ultramarathoner shaved three hours off his Leadville 100 finish time using it strategically. Scott and Freddie also tackle epigenetic age testing, immunosenescence, the dopamine-draining effects of smartphones on libido and focus, and why screen time may be the most underrated threat to your nervous system recovery. Plus — a full breakdown of the Troscriptions product suite: TruCalm, TruZ, TruImmune, and methylene blue's role in each.Episode Highlights [04:27] – Dr. Scott explains how his work now spans clinical care, practitioner training, and product development [06:35] – Why mitochondrial function has become the foundation of his approach to health and recovery [07:42] – What likely caused recent hyperbaric chamber accidents and why safety protocols matter [13:12] – Why stacking devices inside a chamber creates unnecessary risk [15:16] – The problem with influencer protocols and overcomplicating health routines [18:52] – Soft-shell vs. hard-shell chambers and how pressure impacts oxidative stress [22:42] – A practical framework for intensive vs. maintenance hyperbaric use [27:59] – Why direct mitochondrial testing is limited and how metabolomics fills the gap [29:55] – Common signs of mitochondrial dysfunction, from brain fog to poor recovery [35:53] – Dr. Scott revisits methylene blue and challenges common misconceptions [39:28] – Why most people may benefit from mitochondrial support despite “not being sick” [41:44] – How to think about dosing and what a proper response should feel like [44:04] – The role of sympathetic dominance in blocking healing and recovery [46:04] – Why longevity metrics need context beyond just improving numbers [50:16] – How screen time and dopamine overload impact energy, libido, and focus [53:08] – The expanding Troscriptions product line and the goal of needing less over time Scott's First Episode: https://open.spotify.com/episode/42vjXWQ9HAFqOd2avJsj6n?si=76da7d2114694e6a   Links & Resources Connect with Dr. Scott Sherr: https://www.instagram.com/drscottsherr/ Buy Troscriptions: https://troscriptions.com/?rfsn=9066612.3f3859&utm_source=refersion&utm_medium=affiliate&utm_campaign=9066612.3f3859 Use Code: BeautifullyBroken Silver Biotics: https://bit.ly/3JnxyDD Use Code: beautifullybroken   CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What early signs could indicate your metabolism is breaking down? I sat down with Dr. Scott Sherr, a physician focused on health optimization and mitochondrial function, to unpack why so many women feel exhausted despite doing everything “right.” We explored how chronic stress and declining energy production create a hidden cycle that leaves you burned out, especially in midlife. I wanted to help you understand what's really going on beneath the surface so you can start rebuilding your energy and resilience. Today's topics: (00:00) What the “sympathetic spiral of doom” is and how constant stress keeps your body stuck in overdrive. (00:44) How mitochondria produce energy and why your body struggles when demand exceeds capacity. (01:19) Why hustle culture and chronic stress deplete your energy reserves over time. (02:12) How midlife hormonal changes amplify fatigue, weight gain, and poor recovery. (03:27) Why this issue is more widespread than most people realize and often goes undetected. (06:17) How your body compensates for dysfunction until it suddenly crashes. (07:14) The difference between top-down stressors and bottom-up biological dysfunction. (10:48) Why supporting mitochondrial health first is key before addressing stress directly. Listen to the full episode: https://youtu.be/SHtizobaR1E?si=kjk4MPmOwgzjFYz9 Full show notes (including all links mentioned): https://jjvirgin.com/cellularhealth Learn more about your ad choices. Visit megaphone.fm/adchoices

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection

What if feeling better didn't have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn't what it used to be, and there's a constant sense of stress that doesn't seem to resolve. We walk through what's actually happening beneath the surface, why it can be so hard to break out of that pattern once you're in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What's keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn't always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn't have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Korrus, Timeline, BON CHARGE, BIOptimizers and Pique. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. (0:00) Introduction and guest Dr. Scott Scherer (3:31) Understanding the sympathetic spiral of doom (5:06) Symptoms and signs of sympathetic overdrive (7:10) Sympathetic activation, mitochondrial function, and stress (10:02) Mitochondria: their role and impact in the body (12:31) Stress, metabolic dysfunction, and their effects (17:43) Nervous system, mitochondria, and the cell danger response (21:25) Survival, stress, and breaking the sympathetic spiral (23:11) Contributors to stress: top-down and bottom-up (25:56) Mitochondria, microbiome, and medication impacts (29:38) Mitochondrial dysfunction and mental health (32:19) Limitations of parasympathetic activation and addressing root causes (36:46) How mitochondrial stress leads to fight-or-flight (37:52) Steps to break the sympathetic spiral and support mitochondria (42:41) Methylene blue: benefits, uses, and safety (50:35) Methylene blue as an MAO inhibitor and for chronic infections (57:17) Case studies, third-party testing, and Transcriptions' evolution (1:02:36) Parasympathetic edge, recovery, and the GABA system (1:07:44) GABA, supplements, and interventions for stress (1:12:23) Addressing root causes and methylene blue usage (1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem (1:19:49) OneBase Health, hyperbaric space, and final information

What happens when chronic stress and low energy begin feeding each other in a loop that feels impossible to escape? This week on Health Coach Talk, Dr. Sandi welcomes Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization medicine and hyperbaric oxygen therapy, for a fascinating conversation about the connections between the nervous system, mitochondrial health, and healing. Together, they explore why so many people feel “wired but tired” and what may be happening beneath the surface when clients are doing all the right things but still not feeling better.Full show notes: https://functionalmedicinecoaching.org/podcast/scott-sherr-175/

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.Ready to nerd out in this with us?Let's dive in!What's Discussed:(4:00) The number that changes how you think about skin aging.(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.(8:18) The three enzyme families consuming your NAD+ as a substrate.(8:23) Sirtuins: the police of your cells and what they cost you.(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.(11:16) CD38: the NAD+ Pac-Man that gets worse with age.(15:10) The five-fold decline: what the 2012 tissue study actually found.(16:15) CD38 and the zombie cell feedback loop driving the decline.(19:39) What the depletion actually looks like in the mirror.(28:04) Why NAD+ decline is reversible & supplementation deep dive.(28:41) NMN: how it works and what the studies actually show.(31:50) NR: the most clinically studied precursor and who it's best for.(33:27) Niacin: the $5 option and why most people can't tolerate it.(38:14) Why timing your NAD+ to your circadian rhythm matters.(38:35) TMG and methylation: what to stack and the two-to-one ratio.Learn more about NAD from our previous podcasts and videos:Previous NAD YouTube Videos:NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0 The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XM Previous NAD Podcasts:NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123 The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462 The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098 Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945 Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344 Research Studies Mentioned: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357 CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7 Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3 Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/ Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1 Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7 Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% offBody Cream: Head to younggoose.com/products/youth-body-cream for 20% off

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems.  Dr. Sherr also shares how he's used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework. Sponsors: TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde CODE: DRMIKE Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Coming up: ISSN 2026: https://www.sportsnutritionsociety.org/ Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:11 Why Methylene Blue Now 04:29 Scott Cher Origin Story 05:05 Health Optimization Framework 07:08 Transcriptions and Safe Sourcing 08:46 Natural vs Synthetic Debate 11:49 How Methylene Blue Works 17:42 Who Benefits Most 22:13 Athletic Performance and Recovery 29:41 Dosing Timing and MAOI Effects 32:13 Mitochondria and Fertility 32:28 Energy Anxiety and Brain Fog 33:13 Depression Beyond Serotonin 35:30 Stress Pathways and Cell Danger 37:00 ADHD or Sympathetic Overdrive 38:50 Recovery Metrics and Downregulation 42:21 GABA Support and BBB Clues 47:50 Building Mitochondrial Capacity First 51:35 Methylene Blue Dosing Guide 57:54 Where to Learn More 01:00:24 Podcast Wrap and Disclaimer  Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw Connect with Dr Sherr: Instagram: https://www.instagram.com/drscottsherr/ Website: https://drscottsherr.com/ YouTube: https://www.youtube.com/@drscottsherr Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

Could a low dose of methylene blue be the missing "bridge" to help you overcome chronic brain fog and fatigue? In this episode, I sit down with Dr. Scott Sherr, a leading expert in health optimization and hyperbaric medicine, to dive deep into the world of cellular energy and recovery. We explore why foundational health is the key to making "biohacks" like methylene blue and hyperbaric oxygen therapy actually work for your body instead of just causing more stress. My goal is to help you understand how to master your nervous system and support your mitochondria so you can age powerfully and maintain your independence for years to come. What you'll learn: (00:00) How methylene blue supports both energy production and detoxification at the cellular level. (05:33) Why calming your nervous system can initially feel uncomfortable—and why that's normal. (06:34) How shifting between stress and recovery states improves performance and reduces injury risk. (07:10) Why post-workout recovery habits like breathwork and rest are essential for results. (09:24) What methylene blue actually is and how it became a powerful tool for health. (13:30) How low oxygen environments like airplanes impact your energy and mitochondria. (22:57) The real benefits of hyperbaric oxygen therapy and who should use it. (34:41) Why your evening routine matters more than your morning routine for better sleep. Love the podcast? Here's what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you're ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/hyperbarichealth Learn more about your ad choices. Visit megaphone.fm/adchoices

Hyperbaric oxygen therapy is one of the most powerful tools in modern integrative medicine… but most people don't actually understand what it does or when it should be used. This week we are joined by Dr. Scott Sherr, a board-certified internal medicine physician and hyperbaric oxygen therapy specialist, to explore how oxygen under pressure influences healing at the cellular level. He unpacks how hyperbaric therapy supports stem cell activity, reduces inflammation, improves mitochondrial function, and helps the body repair itself more efficiently. Just as importantly, Dr. Sherr explains why timing matters and why advanced therapies often work best after foundational health systems are optimized first. The conversation also explores methylene blue for mitochondrial support and GABA's role in calming an overactive nervous system, offering practical insight into how energy, stress, and recovery are deeply connected. If you've ever wondered whether hyperbaric oxygen therapy could support brain health, chronic illness recovery, or long-term resilience, this episode brings clarity to what's really happening inside the chamber. Dr. Scott Sherr is a board-certified internal medicine physician, Health Optimization Medicine practitioner, and hyperbaric oxygen therapy specialist. He serves as Chief Medical and Health Education Officer at Troscriptions and works with integrative technologies supporting energy, recovery, and nervous system health. ✴️ Connect with Dr. Sherr on Instagram, YouTube, or Linkedin ✳️ Learn more about Dr. Sherr's work through his organizations Troscriptions, HomeHope, and One Base Health.    

In this episode, Dr. Jockers sits down with Dr. Scott Sherr to break down why so many people are stuck in fight or flight and what it's really doing to your brain and body. You'll learn how GABA acts as the "brake system" for your nervous system and why low levels are linked to anxiety, poor sleep, and burnout. They also unpack why fixing stress is not just mental, but deeply biological.   You'll get a clearer picture of what's actually going on inside your cells when you feel exhausted, wired, or mentally foggy. Dr. Sherr explains how your mitochondria play a central role in all of it and why supporting them can change how you feel day to day. They also talk about tools like methylene blue and oxygen therapy, and when they can actually make a difference.   They also get into why constantly pushing harder isn't the answer, and how being able to slow your system down can actually improve your performance. You'll hear what it really means to shift into a parasympathetic state and why so many people struggle to get there. It may change the way you think about stress, recovery, and what your body actually needs.   In This Episode:  00:24 Show Intro and Guest 05:04 Sympathetic Spiral of Doom Explained 08:40 The Parasympathetic Edge 12:32 GABA Gas and Brakes System 15:22 Gut Inflammation and GABA Connection 16:49 Safer Ways to Support GABA 19:55 Alcohol, Benzos and Dependence 22:26 Why Calming Alone Can Backfire 27:13 Mitochondrial Dysfunction Root Causes 30:29 Methylene Blue as an Energy Bridge 32:40 Methylene Blue Controversies 36:20 SSRI Safety Considerations 37:47 High Dose Clinical Use 38:27 Versus CoQ10, PQQ and Creatine 41:29 Hyperbaric Oxygen Basics 43:29 Acute vs Chronic Protocols 46:01 Chamber Pressure Differences 47:17 Health Optimization Medicine Explained 49:55 Trauma and the Sympathetic Loop 55:26 Vagus Nerve Tools and Limits 01:02:54 Performance, Recovery and Closing Insights If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   Experience faster, more effective health optimization with Troscriptions. Their innovative buccal troche delivery system sends ingredients directly into your bloodstream for rapid results, bypassing the digestive system. Whether you need a boost in energy, immune support, or relaxation, Troscriptions has a solution for you. Visit Troscriptions.com/DrJockers and use the code DRJOCKERS for 10% off your first order.  Most people have no idea how polluted their indoor air actually is. I didn't either until I looked into it. The air inside your home can be significantly worse than outside, which is a big deal when you're spending most of your time indoors. That's why I use Air Doctor. It removes 99.99% of contaminants like dust, mold, smoke, and even viruses, so you're breathing cleaner air every day. You can go to airdoctorpro.com and use the code NUTRITION to get up to $300 off. You'll also get a 30 day money back guarantee and a free 3 year warranty. It's one of the simplest upgrades you can make for your health. If you feel like you need caffeine or nicotine just to get through the day, you're definitely not alone. But there's a better option that doesn't come with the crash or the edge. Ultra Pouches give you clean, steady focus using ingredients like L theanine, Alpha GPC, and B vitamins. No caffeine, no nicotine, just smooth energy that actually feels good. Most people notice better focus, more stable energy, and even an improved mood. If you want to try it out, go to takeultra.com and use the code JOCKERS to get 15% off your order. It's a simple switch that can make a big difference in how you feel day to day.     "Most GABA is made in the brain from glutamate using magnesium and vitamin B6. If you're deficient, your nervous system struggles to slow down."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio Resources: Visit takeultra.com and get 15% off with code JOCKERS Visit airdoctorpro.com using code NUTRITION. Visit Troscriptions.com/DrJockers and use the code DRJOCKERS for 10% off.   Connect with Dr. Scott Sherr: Website: https://drscottsherr.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Dr. Scott Sherr is a physician and health optimization expert focused on cellular performance and longevity. Through his HOMe framework, he helps high performers move beyond burnout by mastering foundational health, personalized data, and sustainable optimization strategies. Connect with Dr. Scott: Troscriptions: https://troscriptions.com/ One Base Health: https://onebasehealth.com/ Website: https://drscottsherr.com/ LinkedIn: https://www.linkedin.com/in/drsherr/ Instagram: https://www.instagram.com/drscottsherr  

Why does your metabolism seem to grind to a halt even when you're doing everything "right"? I'm joined by Dr. Scott Sherr, a specialist in health optimization and internal medicine, to dive deep into why so many of us feel completely exhausted and metabolically stuck. We explore the "Sympathetic Spiral of Doom," a state where chronic stress and failing mitochondria leave you wired, tired, and unable to recover. You'll learn why supporting your cellular energy is the foundational first step to reclaiming your resilience and finally breaking free from the cycle of burnout. What you'll learn: (05:30) Why feeling wired and exhausted at the same time is a major red flag. (06:00) What the “sympathetic spiral of doom” is and how it starts. (07:00) How chronic stress and mitochondrial dysfunction feed off each other. (10:00) Why traditional lab tests often miss early warning signs of burnout. (13:00) The difference between top-down stress and bottom-up biological stress. (20:00) How being stuck in fight-or-flight impacts digestion, sleep, and muscle. (24:30) What cortisol really does to your body over time. (29:30) How supporting your mitochondria can improve sleep and reduce anxiety. Love the podcast? Here's what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you're ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/cellularhealth Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Health Optimization Medicine Podcast, join Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore the hidden cost of convenience and comfort in modern life.   From ultra-processed foods and low-fiber diets to sedentary lifestyles and technology-driven comfort, the conversation dives into how convenience is quietly reshaping our biology. The HOMeHOPe Faculty explains why small daily habits — like eating whole foods, moving regularly, and embracing mild discomfort — are essential for maintaining cellular health and resilience.   Rather than trying to "hack" health with quick fixes, the discussion emphasizes consistent lifestyle behaviors that support the microbiome, metabolic function, and long-term health optimization.   Join us as we delve into: • Why fiber is the fastest disappearing macronutrient in modern diets • The role of gut microbiota and short-chain fatty acids in health • Why habits like sleep, eating, and exercise cannot be "banked" • The physiological consequences of ultra-convenient lifestyles • Practical ways to introduce beneficial stress back into daily life   This episode is for you if: • You want to understand how convenience affects human physiology • You're interested in the role of fiber and gut health in disease prevention • You want practical ways to improve resilience and metabolic health • You're curious about the philosophy behind Health Optimization Medicine   You can also find this episode on… YouTube: https://youtu.be/6wLPUuLQgcY   Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/   Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the core philosophical framework behind Health Optimization Medicine. Dr. Scott Sherr, Boomer Anderson, and Dr. Allen Bookatz break down the three fundamental perspective shifts that redefine how we think about health, disease, aging, and the human body itself. Rather than focusing on disease management, this episode introduces the foundational principles behind building health from the cellular level up. Join us as we delve into: • The shift from pathogenesis (studying disease) to salutogenesis (creating health) • Why longevity alone isn't enough without vitality and morbidity compression • How neotenization focuses on restoring youthful biological function • The concept of the holobiont: humans as ecosystems of interconnected organisms This episode is for you if: • You want to understand the philosophy behind Health Optimization Medicine • You're curious why modern healthcare focuses on disease instead of health • You're interested in metabolomics, cellular health, and systems biology • You want a deeper framework for longevity, vitality, and resilience You can also find this episode on… Youtube: https://youtu.be/wuCXmT783_o Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/ Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

I am delighted to reconnect with Dr. Scott Sherr today. In our conversation, we explore the sympathetic spiral of doom that middle-aged women often experience during a pivotal time of life marked by constant shifts in mitochondrial health, hormones, and neurotransmitters. We explore what it is and how to reframe it, and offer advice on navigating that stage of life and setting the tone for the decades to follow. Join us for an empowering discussion where we share practical strategies to interrupt the spiral, reset your nervous system, avoid burnout, and shape the trajectory of your future. IN THIS EPISODE, YOU WILL LEARN: Why the intense practices promoted by wellness trends are not advisable for stressed-out individuals The importance of having a flexible nervous system that can rise under stress and return to parasympathetic calm How calming the nervous system improves your mental clarity, focus, and decision-making ability Many stress reactions may be more about how we respond than the actual event that occurred The value of doing micro-resets to regulate your emotions quickly How sighing, prolonged exhales, humming, and gargling stimulate the vagus nerve and strengthen the parasympathetic system Sleep is essential for supporting mitochondrial function, mood, and the ability to handle stress Fight-or-flight mode  may damage your cellular energy systems Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Scott Sherr On his website Troscriptions - Use promo code CYNTHIA10 for 10% off Health Optimization Medicine One Base Health  Previous Episodes with Cynthia Thurlow and Dr. Scott Sherr Calm, Clear, & Balanced: How GABA & Progesterone Unlock Stress Relief & Hormone Harmony | S. Sherr The Future of Healing: HBOT, Methylene Blue & Cellular Regeneration | Dr. Scott Sherr

In this episode of the Smarter Not Harder Podcast, Dr. Helen Messier joins Dr. Scott Sherr for a wide-ranging and thought-provoking conversation about longevity, epigenetics, AI-powered medicine, and the real meaning of healthspan. From whole genome sequencing to digital twins and emotional resilience, this episode bridges cutting-edge science with deeply human healing in a way that challenges how we think about aging. Join us as we delve into: The difference between lifespan and healthspan — and why resilience matters more than years Whole genome sequencing, polygenic risk scores, and the limits of genetic hype Multi-omics medicine: genomics, metabolomics, proteomics, and systems biology AI in healthcare, digital twins, and the return of the "country doctor" model This episode is for you if: You're curious about biological age vs. chronological age You want to understand what genetic testing can (and can't) tell you You're fascinated by AI's role in the future of personalized medicine You want smarter, not harder ways to build resilience and optimize longevity You can also find this episode on… Youtube: https://youtu.be/QQ-kIH3XbF0 Learn more about Dr. Helen Messier: Fountain Life: https://www.fountainlife.com/ Instagram: https://www.instagram.com/fountainlife/ Website: https://www.ifm.org/educator/helen-messier LinkedIn: https://www.linkedin.com/in/helen-messier-phd-md/ Find more from Smarter Not Harder: Website: Smarter Not Harder Podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRG and save up to 39% off your Mitopure® Gummies. → Puori | Go to https://puori.com/DRG and use the code DRG at checkout to get 32% off your first Puori Creatine+ subscription order. → My one stop shop for quality supplements: https://theswellscore.com/pages/drg Episode Description Your body isn't broken. It's stuck — and there's a very specific reason why. 94% of U.S. adults have some degree of mitochondrial dysfunction. That means the majority of people walking around right now can't make energy efficiently — and they're using caffeine, stimulants, and willpower to paper over it. Dr. Scott Sherr has spent over a decade figuring out why, and more importantly, how to actually fix it. Board-certified in internal medicine and one of the leading voices in health optimization medicine, Dr. Sherr introduces one of the most important concepts Dr. G has heard in a long time: the sympathetic spiral of doom — the feedback loop between chronic stress and mitochondrial breakdown that keeps you wired, exhausted, and unable to heal no matter what you try. In this episode, you'll discover: • Why more caffeine, more supplements, and more biohacks are making the spiral worse — and what to do instead • The GABA system: why depression and anxiety may have nothing to do with serotonin, and everything to do with your brain's brakes failing • The leaky gut → leaky brain connection most doctors have never heard of • How methylene blue works at the mitochondrial level — and why dose and source matter more than you think • What it actually means to optimize your health back to the resilience of your 20s — at any age If you've seen 10 doctors, tried every supplement, and still feel like you can't recover — this episode is the missing piece. Find Dr Sherr: Website: https://www.hyperbaricmedicalsolutions.com/integrative-hbot/scott-sherr Instagram: https://www.instagram.com/drscottsherr  Timestamps: 0:00 - Introduction 0:35 - Rapid Fire Q&A: Caffeine, Methylene Blue & Mitochondria 2:05 - Dr. Scott's Background: From Hospitalist to Health Optimization 8:50 - What Is Health Optimization Medicine? (Ages 21–30 Blueprint) 16:20 - The Sympathetic Spiral of Doom Explained 24:30 - Signs You're Stuck in Fight-or-Flight Mode 33:00 - The GABA System: Why Supplements Don't Cross the Blood-Brain Barrier 43:57 - Methylene Blue Deep Dive: How It Works & Who It's For 51:17 - How to Shop for Methylene Blue (Quality & Dosing Guide) 56:29 - Dr. Scott's Personal Routine for Mitochondria & Nervous System Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Smarter Not Harder Podcast, Dr. Linda Kiley joins Dr. Scott Sherr for a groundbreaking conversation on functional urogynecology — exploring the real causes of pelvic and bladder pain that most conventional models miss. Dr. Kiley shares how she uses muscle exams, peptide protocols, and root-cause diagnostics to treat conditions like interstitial cystitis, chronic UTIs, pelvic floor dysfunction, and endometriosis — often without surgery or long-term antibiotics. If you or someone you love has been told "there's nothing wrong" but still struggles with pelvic discomfort, bladder issues, or sexual pain, this episode is a must-listen. Join us as we explore: • The pelvic floor as a dynamic system — not just "tight or weak" • Biofilms, interstitial cystitis, and smart testing for chronic infections • How gut health and systemic inflammation drive pelvic pain • Natural, non-invasive approaches to bladder and pelvic restoration This episode is for you if: • You experience chronic UTIs, bladder discomfort, or pelvic pain • You've been dismissed or misdiagnosed by conventional providers • You're a clinician seeking better diagnostics for pelvic dysfunction • You want to understand how muscle tone, breathing, and biofilms intersect You can also find this episode on… YouTube: https://youtu.be/S0i5vKoLfEk Find more from Dr. Linda Kiley: Website: https://drlindakiley.com/ Instagram: https://www.instagram.com/drkileyurogyn/ YouTube: https://www.youtube.com/@theholisticurogynecologist3891 LinkedIn: https://www.linkedin.com/in/linda-kiley-5999462b/ More from Smarter Not Harder: Website: Smarter Not Harder podcast Instagram: https://instagram.com/troscriptions/ HOMeHOPe Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Get 10% off your purchase of the Clinical Metabolomics module with code PODCAST10 at https://www.homehope.org/ Get 10% off your Troscriptions purchase with code POD10 at https://www.troscriptions.com/ Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

In this episode of the Evolving Wellness Podcast, host Sarah Kleiner welcomes back Dr. Scott to discuss the 'sympathetic spiral of doom' and how modern lifestyles contribute to chronic stress and energy depletion. Dr. Scott shares insights into how overstimulation, poor diet, and interrupted sleep cycles can lead to nervous system dysregulation and mitochondrial dysfunction. The conversation covers the importance of circadian rhythm, hydration, and low-hanging fruit lifestyle changes to support overall wellbeing. They also explore the potential benefits of methylene blue, red light therapy, and other practical tools for regaining optimal health. Tune in to learn more about foundational steps to improve energy levels and break free from chronic stress.About Dr. ScottDr. Scott Sherr is a Board-Certified Internal Medicine Physician Certified to Practice Health Optimization Medicine (HOMe), a specialist in Hyperbaric Oxygen Therapy (HBOT), and COO of Troscriptions (a Smarter Not Harder company). His clinical telepractice includes HOMe as its foundation alongside an integrative approach to HBOT that includes cutting edge and dynamic HBOT protocols, comprehensive testing (using the HOMe framework), targeted supplementation, personal practices, synergistic technologies (new, ancient, psychedelic), and moreConnect with Dr. Scott - https://www.linkedin.com/in/drsherr/ _________Sponsored By:→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide.→ VivaRays | This episode is sponsored by VivaRays - VivaRays Blue - code YOGI https://vivarays.com/ → Organifi | For an exclusive offer, go to https://www.organifi.com/SARAHK for 20% off your order._________Timestamp:00:00 Introduction and Personal Experience with Coffee00:51 Welcome to the Evolving Wellness Podcast03:37 Understanding the Sympathetic Spiral of Doom06:29 The Role of the Nervous System and Mitochondria10:53 Practical Tips for Nervous System Regulation16:53 The Importance of Circadian Rhythm and Light Exposure25:31 Supporting Mitochondrial Health and Energy Production36:17 The State of Metabolic Health in the US36:55 Improving Mitochondrial Function37:27 Addressing Trauma and Sympathetic Overdrive38:31 The Importance of a Supportive Environment40:38 Sleep and Its Impact on Health44:35 The Role of Blue Blockers and Sleep Aids48:21 Caffeine and Its Effects on the Body50:46 The Benefits of Exogenous Ketones58:56 Navigating the Sympathetic Spiral of Doom01:05:14 Final Thoughts and Resources——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

We talk with Dr. Scott Sherr rto talk health optimization from the practical to the “hold up… what?” level.We get into light and red light therapy, mitochondria and metabolism, nitric oxide (and why mouthwash can wreck it), the “toxic bucket” concept for modern exposures, EMF/5G concerns and mitigation, and why environment matters more than most people think.Then we go deeper: psychedelics, default mode network, ketamine and integration, marijuana risks for younger users, and how perspective and nervous system regulation can change the game for recovery, sleep, and performance.Special perks for our listeners below!

In this episode, we're joined by Dr. Scott Sherr to break down how the nervous system actually drives performance, recovery, sleep, and long-term health.We dive into sympathetic vs parasympathetic balance, why being overly stimulated before training can limit gains, how to down-regulate between sets and after workouts, and why many people struggle with sleep even when they “do everything right.”We also cover cortisol rhythms, late-night training, GABA, melatonin misconceptions, recovery strategies, and why optimizing health isn't about one supplement—it's about the whole system working together.Special perks for our listeners below!

Dr. Scott Sherr is a Board Certified Internal Medicine Physician Certified in Hyperbaric Oxygen Therapy (HBOT) and Health Optimization Medicine (HOMe). He's a methylene blue expert. Show partners: Troscriptions - 10% off your first order by using the code "JESSE" at checkout LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Quicksilver Scientific - 15% off your first order by using the code "jesse15" at checkout Show notes: https://jessechappus.com/689