Podcasts about troscriptions

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Jup Kuipers, and Jodi Duval take a deep dive into the gut-brain-microbiota axis. Moving past the simplistic, pathogenic "pill-for-an-ill" approach of conventional psychiatry and the mainstream hype around over-the-counter probiotics, the faculty breaks down why establishing enteric safety must always precede biochemical optimization. Join us as we delve into: The Tripartite Axis: How the enteric microbiota, gut barrier, and central nervous system communicate at a molecular and metabolomic level to dictate brain state and mood. Epigenetic Signaling: How gut microbes act as active metabolic factories, fermenting dietary fibers into short-chain fatty acids (SCFAs) like butyrate that cross the blood-brain barrier to upregulate BDNF and support synaptic plasticity. The IDO Serotonin Hijack: How gut-driven inflammation activates indolamine 2,3-dioxygenase (IDO), shunting tryptophan down the kynurenine pathway to produce neurotoxic quinolinic acid instead of serotonin and melatonin. The Microglial Fire: How circulating cytokines cross the blood-brain barrier at the circumventricular organs, placing the brain's microglia into an active defense state that triggers cognitive fatigue and brain fog. The 3-Phase Gut-Brain Protocol: Why seeding probiotics into inflamed soil fails, and how to logically sequence clearing overgrowth, rebuilding mucosal integrity with L-glutamine, and seeding validated strains. This episode is for you if: You are running on high-dose over-the-counter probiotics for mood issues but feeling no relief or worsening symptoms. You want to understand the exact cellular and biochemical mechanisms connecting leaky gut to leaky brain and psychiatric distress. You want a practical, clinically sequenced blueprint to restore gut barrier safety before attempting to optimize your neurochemistry. You can also find this episode on… YouTube: https://youtu.be/A43LDN6FgvA  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Today we have Dr. Scott Sherr, an internal medicine physician who specializes in Hyperbaric Oxygen Therapy. Scott is the director of Integrative Hyperbaric Medicine and Heath Optimization at Hyperbaric Medical Solutions. It is a division of Hyperbaric Medical Solutions, an independent, hyperbaric oxygen therapy provider that aims to educate people about the benefits of hyperbaric oxygen therapy via telemedicine consulting. He also is COO of Troscriptions, which provides physician-formulated products including popular methylene blue products. In today’s interview, Scott talks about how he uses Hyperbaric Oxygen Therapy (HBOT) to treat a number of health conditions. He also shares how he incorporates methylene blue into some of his treatment strategies and explains how HBOT is now being used as a complementary treatment for autoimmune diseases by helping reduce inflammation, improve blood flow and support immune function. Show notes: [00:03:29] Dawn tells Scott that she heard a story that Scott had his spine adjusted when he was just five minutes old.  She asks Scott if he can share what happened. [00:04:15] Dawn mentions that Scott grew up in New York on Long Island and that as a child he spent a lot of time at his father's chiropractic office. Dawn asks Scott about his father and his practice. [00:05:38] Ken notes that Scott was into sports as a kid and asks him to talk about his childhood and what he was like as a kid. [00:07:09] Dawn notes that after high school, Scott left New York for the West Coast, landing at UCLA. Dawn asks Scott to talk about what led him there. [00:08:00] Dawn explains that Scott initially started to major in biology but quickly changed majors. Scott explains why he changed majors. [00:08:41] Dawn asks Scott why he chose to attend the University of Maryland for medical school after graduating from UCLA. [00:09:26] Dawn asks Scott about the story of how he met his wife at the University of Maryland. [00:09:50] Dawn pivots back to Scott's love of music, mentioning that Scott and three other medical school students at Maryland formed a band called The Airport Rocking Chairs. Scott describes how the band came together and how they performed at gigs around the Baltimore/D.C. area. [00:11:16] Ken asks Scott to talk about how his early ambition upon entering medical school was to find a way to bridge the gap between conventional and alternative/chiropractic medicine. [00:12:54] Ken explains that in Scott's third year of medical school, he did rotations at the University Shock and Trauma Facility. Ken asks Scott to talk about why this was such an important experience for Scott. [00:14:32] Dawn explains that hyperbaric chambers are used to treat injuries like necrotizing fasciitis and severe wounds. Dawn asks Scott to talk about finding a hyperbaric chamber in the basement of the University Shock and Trauma Facility and how that led to his fascination with the potential for hyperbaric oxygen therapy. [00:15:51] Dawn asks Scott to talk about how his initial research on hyperbaric therapies led him to conclude that they were being vastly underutilized in conventional medicine. [00:16:31] Dawn mentions that people are likely familiar with hyperbaric oxygen therapy (HBOT) in terms of treating divers suffering from decompression sickness. She asks Scott to give a primer on the mechanisms by which HBOT affects the body and why it has potential to treat other conditions besides decompression sickness. [00:19:38] Ken asks Scott to talk more about other conditions, both acute and chronic, that HBOT might be helpful in treating. [00:22:51] Dawn asks about Scott's experience as a hospitalist, which is an internal medicine physician who acts as a primary care physician in a hospital, and how this experience gave him a unique perspective on the strengths and limitations of modern medicine. [00:25:13] Ken asks Scott if it's fair to say that his experience as a hospitalist was foundational in developing his understanding of patient care and healthspan. [00:26:51] Dawn explains that when Scott's wife received a fellowship at Stanford University, Scott eventually left his career as a hospitalist to serve as the medical director for a hyperbaric medicine facility in the San Francisco Bay area. Dawn asks Scott to talk about how this experience deepened his understanding and expertise in hyperbaric oxygen therapy. [00:28:26] Ken asks Scott to talk about his relationship with Dominic D'Agostino, who was our recent guest on STEM-Talk episode 196, and who is very active in the field of hyperbaric oxygen therapy. [00:30:48] Dawn mentions that during Scott's work as a hospitalist, he began to develop a more integrated approach to hyperbaric medicine, taking nutritional status, sleep patterns, mitochondrial function, and a number of other factors into consideration. Doing this work, Scott noticed that a number of patients would require weeks or months of preparation before beginning HBOT, contrary to the status quo of the time. Dawn asks Scott to talk about his insights and how this experience changed his views on medicine. [00:33:19] Dawn asks Scott to talk about the evolution of his work in developing an integrative hyperbaric medicine model and how he caught the attention of HBOT practitioners around the world. [00:35:21] Ken notes that interest in hyperbaric oxygen therapy has grown substantially in the last 20 years and goes on to mention that a particularly promising application of HBOT is as a complementary treatment for autoimmune diseases, being shown to reduce inflammation, improve blood flow and support immune function. Ken asks Scott to talk in depth about HBOT in the context of autoimmune disease treatment. [00:39:13] Following up on Scott's mention of epigenetic changes following HBOT, Ken asks if this has been directly measured and if so, how long are these changes sustained. [00:41:14] Dawn asks Scott about the potential for HBOT to be used for athletes looking to speed up their recovery times from injuries. [00:43:19] Dawn asks Scott if there are certain populations who should avoid HBOT. [00:46:27] In order to optimize HBOT, Dawn explains that Scott works with people to tailor their treatment to their individual needs and asks Scott to walk listeners through how this process works in practice. [00:50:00] Ken notes that most HBOT studies describe dosages of HBOT in terms of oxygen concentration, oxygen pressure and number of sessions. He asks Scott how he defines a “dose” biologically and what metrics he uses to tell whether a patient has received enough treatment to induce durable change? [00:53:40] Ken asks Scott if his experience treating patients has informed him on different characteristics that can predict whether a patient will have a robust response to HBOT. [00:56:01] Dawn mentions that the benefits of HBOT are often explained in terms of either improved oxygen delivery or improved mitochondrial signaling and neuroplasticity. Dawn asks Scott what mechanisms are most important in the context of chronic neurological disease. [00:58:04] Dawn asks Scott for his thoughts on the hyperoxic-hypoxic paradox (HHP) as an explanation of HBOT-induced adaptation. [01:00:28] Ken asks Scott if he could only measure three variables before and after HBOT treatment, what would they be. [01:03:43] Ken goes on to asks Scott what he sees as the most important unanswered question in HBOT today. [01:06:22] Dawn mentions that in 2017 Scott met Dr. Ted Achacoso, who is the founder of Health Optimization Medicine. Dawn asks Scott to explain how Ted introduced him to a fundamentally different framework for understanding health. [01:10:08] Circling back to the topic of bridging the gap between conventional and alternative medicine, Dawn mentions that Scott has become part of a practice that isn't afraid to tap into therapies that break from conventional medicine. As an example, Dawn explains that Scott sometimes integrates psychedelic therapy with HBOT. Dawn asks Scott to talk about the framework he uses, combining HBOT with psychedelic therapy. [01:13:56] Ken mentions that Scott also incorporates methylene blue into some of his treatment strategies, Ken directs listeners interested in learning more about how methylene blue can improve cognitive function and energy production to listen to STEM-Talk episode 191 with Francisco Gonzalez-Lima. Ken asks Scott to talk about his use of methylene blue in his practice. [01:20:15] Dawn asks Scott where people can go to learn more about him and his practice. [01:22:33] Ken asks Scott if he has any new projects looming on the horizon. [01:23:54] Dawn closes our interview with Scott by asking if he still plays guitar and if his old band The Airport Rocking Chairs have any plans for a reunion. Links: Scott Sherr bio Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio  

In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz, Dr. Ted Achacoso, and Jodi Duval tackle the widespread trend of supplement fatigue. As biohacking becomes a mindset of treating symptoms with heavy stimulants and endless pills, the faculty breaks down why forcing adaptation on an exhausted system only drives the body deeper into a chronic state of inflammatory defense. From the biophysics of the Cell Danger Response (CDR1) to practical parasympathetic upregulation, this roundtable shifts the focus from treating disease to establishing true autonomic safety. Join us as we delve into: The Cell Danger Response (CDR1): How a sympathetic fight-or-flight state physically stiffens cell membranes and halts aerobic respiration. The Vagal Superhighway: How sympathetic dominance halts gut motility, triggers dysbiosis, and blocks neurotransmitter synthesis. The Autonomic Safety Protocol: The critical importance of chronobiology, early morning sunlight, and circadian anchors. Vagal Upregulation & GABA Support: Utilizing transcutaneous auricular vagus stimulation (taVNS), L-theanine, and Kava to quiet the central alarm and exit CDR1. The Myth of Extreme Hormesis: Why intense stressors like ice baths and strict fasts act as active threats, not adaptation triggers, when your cells are already depleted. This episode is for you if: You are running on a continuous cycle of intense workouts, strict fasts, and multiple wearables, yet feel more exhausted. You want to understand why your cells cannot use nutrients for energy production when they perceive an active attack. You want to learn how to pulse carefully calibrated hermetic stressors only after restoring baseline energy reserves. You can also find this episode on… YouTube: https://youtu.be/uE3LhioxwZQ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Boomer Anderson: The Archimedes Lever - Why Health Is the Missing Ingredient to High Performance About Boomer Anderson: CEO of Troscriptions and Health Optimization Medicine and Practice Former investment banker who led South Asia debt capital markets while living in Singapore Entrepreneur, investor, and health optimization advocate helping leaders move from reactive healthcare to proactive performance   Health as the Foundation for High Performance: Health is the overlooked ingredient that drives focus, leadership, and sustainable success Investing in health delivers measurable returns in productivity, decision making, and career growth Recovery should match the intensity of work to avoid burnout and improve long-term performance   The Power of Sleep and Recovery: Sleep deprivation impacts decision making similarly to alcohol impairment Sleep debt accumulates over time, affecting relationships, leadership presence, and mental clarity Simple habits, including intentional evening routines, can dramatically improve sleep quality and performance   Movement and Measuring What Matters: Walking, zone two cardio, and consistent movement improve energy, focus, and longevity Aerobic exercise supports brain function through increased brain-derived neurotrophic factor (BDNF) Wearable technology can help leaders monitor sleep, recovery, stress, and overall health to build sustainable habits   Presence Before Performance: Multitasking reduces effectiveness and limits meaningful human connection Being fully present unlocks intuitive intelligence and improves communication, leadership, and decision making Paying attention to body language and subtle cues creates stronger relationships and better business outcomes   Purpose Driven Leadership: Great leadership begins with service rather than ego Enlightened leadership emphasizes contribution, collaboration, and genuine care for others Leading with purpose builds trust, stronger teams, and a lasting legacy   Key Insights: Sustainable success begins by treating health as seriously as professional development Recovery is a competitive advantage, not a luxury Presence creates better conversations, stronger relationships, and more effective leadership Leadership rooted in service and purpose creates greater impact than leadership driven by status or promotion   Connect with Boomer Anderson: Companies: Troscriptions and Health Optimization Medicine and Practice LinkedIn: Boomer Anderson Instagram: @boomersnh Connect with Julie Riga: Stacklist: https://stacklist.app/julieriga Coaching: Learn more about leadership coaching, authentic leadership, and purpose-driven growth Subscribe to Stay On Course wherever you listen to podcasts. #stayoncourse #leadership #highperformance #healthoptimization #selfleadership Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma exchange and "blood washing". Moving past the mainstream marketing of plasmapheresis as a longevity cure-all, the team breaks down why mechanical filtering is only a surface-level fix for microplastic toxicity. From the autonomic anxiety caused by biological lockdown to the clinical application of precision metabolomics, this roundtable shifts the conversation from invasive procedures to measurable, cellular safety signals.   Join us as we delve into: The Protein Corona: How circulating microplastics masquerade as pathogens, triggering localized purinergic signaling and the release of extracellular ATP. The Cell Danger Response (CDR1): Why the body halts oxidative phosphorylation and locks down the cell membrane when invaded, and why blood washing can't touch toxins stuck inside tissue matrices. The Problem with Plasmapheresis: The clinical realities and physiological costs of invasive vascular filtering, including the removal of essential immunoglobulins and clotting factors. The True Detox Protocol: Utilizing organic carbon binders (humic and fulvic acids), phase two liver conjugation (glucuronidation/sulfation), and barrier integrity support to properly excrete microplastics. Pulsed Antioxidant Support: When and why to use targeted NAD, alpha-lipoic acid, NAC, and ubiquinol to transition cells out of a defensive lockdown.   This episode is for you if: You are considering expensive therapies like plasmapheresis to clear environmental toxins. You want to learn how to test your cellular metabolomics for organic acids and brain inflammation. You want to understand how your unique exposome interacts with your cellular safety mechanisms.   You can also find this episode on… YouTube: https://youtu.be/5b4jWqByRAU   Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics   Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

Dr. John Lieurance is a chiropractic neurologist & naturopath focused on regenerative medicine. He's an expert on melatonin & methylene blue.Show partners:Troscriptions - 10% off your first order by using the code "JESSE" at checkoutLMNT - Claim your free LMNT Sample Pack with any purchase by using this linkShow notes:jessechappus.com/712

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern biohacking: sleep tracking. Moving past the mainstream obsession with daily device scores, the team breaks down the biochemical realities of how tracking your HRV might actually be sabotaging your sleep architecture. From the autonomic anxiety caused by digital wearables to the clinical application of precision chronobiology, this roundtable shifts the conversation from algorithmic scores to measurable, cellular safety signals. Join us as we delve into: The Orthosomnia Epidemic: Why waking up to a red recovery score immediately triggers your prefrontal cortex, activates your HPA axis, and flattens your diurnal cortisol curve. The HRV Paradox: Understanding the actual biological markers of Heart Rate Variability and why an algorithmic score doesn't dictate your physical reality. The Cell Danger Response: How the body is only able to sleep when it feels safe, and why the ultimate "detox" might just be a sleep divorce. Your "Do This on Monday" Protocol: Dr. Ted's clinical sleep anchoring technique, and why prioritizing sleep as the first activity of your day changes your entire circadian rhythm. Precision Cellular Nutrients: The clinical difference between taking generic sedatives and utilizing precision magnesium, glycine, and even strategic carbohydrates (like honey) to optimize GABA and melatonin. This episode is for you if: You are experiencing worsening sleep anxiety and chronic insomnia despite meticulously tracking your data every night. You want to learn how to test your cellular metabolomics for brain inflammation instead of relying on a generic smartwatch algorithm. You want to understand how your unique chronobiology dictates your sympathetic and parasympathetic balance. You can also find this episode on… YouTube: https://youtu.be/n71oG96M1Ek Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Zane's calling in from a hostel kitchen in Tokyo and Nico's posted up at Gino the Righty's place in California, but somehow they still pulled off the wildest PicklePod yet. This week: the New Jersey Fives win their third straight MLP event and take over first place in the standings, the league's first-ever four-team trade reshuffles the Chicago Slice and St. Louis Shock, and the guys break down the Casey Diamond/Grayson Goldin injured reserve controversy that's got every GM in the league fired up. Oh, and we finally talk about the scoreboard that collapsed on Brooklyn's Rachel Rohrabacher mid-match — and why MLP's statement on it might have made things worse.

In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont. Moving away from the traditional, siloed medical model of "organology" (treating the heart, gut, and brain as isolated systems managed by different specialists), the faculty discusses why true health optimization requires viewing the human body as a complex, interconnected ecosystem of ecosystems. Join us as we delve into: The Holobiont Paradigm: Why you are not just a single organism, but a super-ecosystem made up of human cells and trillions of cooperating microbiota (including in your cornea, ureters, and gut). The Danger of "Organ" Medicine: How specializing solely in individual organs leads to clinical blind spots, and why common prescriptions like statins and PPIs can quietly disrupt cellular energy (CoQ10) and nutrient absorption system-wide. Metabolomics vs. Genetics: Why your DNA only tells you what might happen, while clinical metabolomics tells you exactly what is happening right now. The Cell Danger Response (CDR): How your metabolites act as powerful epigenetic signalers, turning genes on and off to regulate systemic health and recovery. The N-of-1 Future: Why large randomized controlled trials (RCTs) often fail by completely ignoring the gut microbiome, and why personalized, N-of-1 medicine is the only true path forward. This episode is for you if: You are tired of being bounced between specialists for interconnected symptoms like mood disturbances, fatigue, and chronic bloating. You want to understand the limitations of DNA testing and why measuring real-time metabolites is the gold standard for biohacking. You are a clinician looking to shift your practice from illness management to foundational cellular optimization. You can also find this episode on… YouTube: https://youtu.be/ILwab838zVM Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference: https://homehope.org/ Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

This week I interviewed Dr. Adrijana Kekic!  She is the founder of Futurama, which applies integrated genetic, metabolic, and molecular analysis to individuals who look healthy on paper but feel metabolically stuck, fatigued, or inflamed. We discussed the concept of “cellular drift”, and how dysfunction progresses silently despite normal labs along with: - the importance of understanding fasting insulin  - how she leverages AI to create your roadmap to health - the benefits and downsides to peptidesand her one tip to get your body back to what it once was!Connect with Dr. Kekic: https://www.futurome.com/---FREE Pro-Metabolic Window Eating Guide:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min----Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----If you're serious about building strength and muscle while protecting your joints, grab the B Strong Blood Flow Restriction bands I use and recommend:Go Here: https://bit.ly/4ektMvGUse Coupon Code: BRIANGRYN-----How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

Dr. Scott Sherr is an Internal Medicine Physician certified in Health Optimization Medicine (HOMe), a hyperbaric oxygen therapy (HBOT) expert with over a decade of clinical experience, and the COO of Troscriptions, a company that creates precision-dosed buccal troches with cutting-edge ingredients, including methylene blue and GABA modulators.

In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern nutrition: fiber. Moving past the mainstream trend of "fiber-maxing," the team breaks down the actual biochemical realities of how different forms of fiber interact with your unique gut microbiome. From the surprising hormonal impacts of over-consuming fiber to the rise of localized conditions, this roundtable shifts the conversation from generic dietary rules to precise, measurable, cellular data. Join us as we delve into: The Classification of Fiber: Understanding the biological differences between soluble fiber (which breaks down into calories) and insoluble fiber (which adds bulk to stool). The Fiber Maxing Trap: Why forcing massive amounts of psyllium husk, acacia powder, and green drinks can aggravate conditions like Small Intestinal Bacterial Overgrowth (SIBO) and IBS. The Estrogen Heist: The hidden clinical correlation between high-fiber diets (60g+ per day) and the cessation of menstruation (amenorrhea) in female athletes. Short-Chain Fatty Acids (SCFAs): The crucial roles of propionate, acetate, and butyrate as genetic signalers and the primary fuel source for your large intestine. The Gut as an Immune Organ: Why managing the "gut-associated lymphoid tissue" (GALT) forms the basis of roughly 80% of human immune system function. This episode is for you if: You are experiencing worsening gas, bloating, and discomfort despite eating a "clean, high-fiber" vegetarian or whole-food diet. You want to learn how to test your stool for real-time butyrate levels instead of relying on generic probiotic protocols. You want to understand how your unique gut ecosystem mirrors a complex, balancing rainforest. You can also find this episode on… YouTube:  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

Dr. Lily Johnston is a board-certified vascular surgeon and public health expert trying to put herself out of business by preventing disease. Show partners: Paleovalley - Save 15% off your first order by using this link Troscriptions - 10% off your first order by using the code "JESSE" at checkout Show notes: jessechappus.com/709

Are you suffering from chronic "adult tiredness," or wondering why you immediately get sick the second you finally go on vacation? In this episode of Beauty Bytes, I am joined by Dr. Scott Sherr, a board-certified internal medicine physician, specialist in hyperbaric oxygen therapy, and leader in health optimization medicine. We are doing a massive deep dive into the true powerhouse of your cells: the mitochondria. With only 6% of the US population having optimized mitochondrial function, it is no wonder so many of us are completely exhausted. Dr. Sherr explains why the traditional approach to feeling better is backward, revealing why you must fix your cellular energy before trying to lower your stress and anxiety. We also talk about a fascinating synthetic compound called methylene blue. Dr. Sherr explores how taking it via buccal troches can hack jet lag, eliminate brain fog, and safely jumpstart your biological system. Plus, we cover the real science of hyperbaric oxygen therapy and why your skin is actually your "reverse gut".Guest Information: Dr. Scott Sherr is the Chief Medical Officer of Troscriptions and One Base Health. You can find his products at troscriptions.com and learn more about his health optimization practice at drscottsherr.com.

Do you feel exhausted but can't seem to wind down? That wired-but-tired feeling so many women experience in midlife has a name, and a cause most doctors never address. In this episode of The Art of Living Well Podcast®, Marnie and Stephanie are joined by Dr. Scott Sherr, a board-certified internal medicine physician and expert in health optimization, to explore the connection between chronic stress, hormone changes, and mitochondrial dysfunction. Dr. Scott introduces the concept of the "sympathetic spiral of doom" — the cycle of stress, poor sleep, and cellular energy breakdown that keeps so many women stuck, and shares practical, science-backed ways to break it. The conversation covers methylene blue (what it is, how it works, and who should use it), GABA and nervous system support, and hyperbaric oxygen therapy. Dr. Scott also explains why only 6% of US adults have optimally functioning mitochondria, and what the other 94% can do about it. Key Takeaways: Chronic stress and hormone fluctuations directly impair mitochondrial function Estrogen is a critical mitochondrial optimizer, losing it in perimenopause has real cellular consequences Only 6% of US adults are metabolically healthy; symptoms of the rest range from brain fog to poor sleep to slow recovery Methylene blue supports mitochondrial energy production and works as a bridge while you optimize your health more broadly If a GABA supplement works for you, that's a warning sign worth paying attention to Down-regulating the nervous system too fast, without mitochondrial support, can cause a crash Hyperbaric oxygen therapy is most effective once you have a foundational health plan in place Sleep is one of the most powerful levers for mitochondrial health 00:00 – Introduction and Dr. Scott's background 04:13 – Why midlife women's bodies stop responding the way they used to 07:32 – Progesterone, GABA, and sleep disruption 09:04 – What mitochondria actually do and why they matter 13:16 – The 6% metabolic health statistic 17:00 – The sympathetic spiral of doom, explained 21:01 – Cortisol: misunderstood and mismanaged 29:32 – What methylene blue is and how to use it 33:55 – Who should not take methylene blue 38:33 – Performance, travel, and targeted use 47:17 – GABA support and down-regulating the nervous system 55:18 – Hyperbaric oxygen therapy: benefits, timing, and protocols 01:00:52 – One action to take today 01:03:09 – Where to find Dr. Scott and his products Guest Links: Dr. Scott Sherr: drscottsherr.com Troscriptions: troscriptions.com Use code LIVINGWELL for 10% off Products mentioned: Just Blue, Blue Cannatine, Tro Calm, Tro Zzz This episode is brought to you by Good Health Saunas. Visit goodhealthsaunas.com and mention The Art of Living Well Podcast® for exclusive pricing. Ready for a Reset, On Your Own Time? If you've been feeling sluggish, bloated, inflamed, foggy, or just not like yourself, our Vitality Reboot Anytime is a simple way to give your body the reset it's been craving. This is our do-it-yourself version of The Art of Living Well Podcast® community detox, designed so you can move through the program whenever it works best for you. You'll receive everything you need to support your body with nourishing foods, targeted detox support, and simple daily practices that help you feel lighter, clearer, and more energized. Subscribe to our Substack for wellness tips, episode updates, and your free Midlife Travel Resilience Checklist: theartoflivingwell.substack.com Follow us: Instagram: @theartofliving_well YouTube: @theartoflivingwellpodcast LinkedIn: The Art of Living Well Podcast TikTok: @theartoflivingwel Spotify and Apple Podcasts Connect with your hosts: theartoflivingwell.us/about-us

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears. Join us as we delve into: •The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology. •Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly. •The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture. •The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress. •Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end. This episode is for you if: •You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work. •You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers. •You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint. You can also find this episode on… YouTube: https://youtu.be/DygsezbmZxM  Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

This week I interviewed Dr. Aleksandra Gajer, MD—a board-certified physician, metabolic health expert, and founder of The Gajer Practice. Her clinic is dedicated to a root-cause focused approach, helping patients reclaim energy, balance hormones, and optimize whole-body performance. We discussed how she uses peptides to optimize metabolic health along with:- Important Labs to look for - The problem with too much restriction-  Why weight gain in midlife isn't your faultand her one tip to get your body back to what it once was!Connect with Dr. Gajer:  https://thegajerpractice.com/-------------Click to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

In this episode, Leigh Ann welcomes Dr. Scott Sherr, co-founder of Troscriptions, for a conversation on GABA, anxiety, stress, sleep, and fast-acting nervous system support. Dr. Sherr shares how his background in internal medicine, hyperbaric oxygen therapy, and health optimization medicine led him to help create products designed to support people while they are on a longer healing journey. He explains why many people may be struggling with GABA deficiency, how chronic stress can deplete the body's calming pathways, and why anxiety, insomnia, racing thoughts, and low energy are often interconnected. Leigh Ann and Dr. Sherr discuss the unique buccal troche delivery method, how it differs from capsules and sublingual supplements, and why it can allow for faster absorption and more flexible dosing. The conversation also explores TroCalm, Trozy, alcohol's impact on the GABA-glutamate balance, sleep architecture, and why calming the nervous system does not have to mean feeling sedated.Product Discount Codes + LinksHoolest: Website (Discount Code: THEACCRESCENT10)Froya Hair Care: Website (Link gives 10% off)Herbal Face Food: Website (Discount Code: LAL30)Episode LinksTroscriptions - Website (Discount Code: LEIGHANN)Guest InfoDr. Scott Sherr - WebsiteRelated EpisodesPodcast Ep. 203: Anna Finck - Reconnecting to Our Bodies, Reclaiming Our Health, and Remembering Our PowerPodcast Ep. 150: Michael Byrne - The Bia Smart Sleep MaskWork w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Healing Alchemy MembershipConnect w/Me & Learn MoreWebsiteInstagramTiktokYoutube

If you've been doing everything right and still feel exhausted, anxious, and like your body just won't cooperate — this episode is for you. I sat down with Dr. Scott Sherr, a board-certified internal medicine physician and COO of Troscriptions, to talk about the sympathetic spiral: a chronic fight-or-flight loop most people don't even know they're in. And here's what surprised me most — you don't have to feel stressed to be stuck in it. We get into why your cellular energy and your anxiety are locked in a loop, what mitochondrial dysfunction actually means for your daily life, and how a specific sequence of support can help you finally start feeling better. We also go deep on methylene blue — the history, how it works, the right dosing range, and the sourcing and safety details that most people skip (including who should absolutely not use it). Plus: why GABA deficiency is so common, how to calm your nervous system without sedating yourself, and why sleep is a full-day practice — not just a bedtime routine. For the complete show notes, links and transcripts, visit inspiredliving.show/247

Hyperbaric oxygen therapy or HBOT is one of the most scientifically validated yet underutilized treatments in modern medicine. And Dr. Scott Sherr has spent his career proving exactly why. In this episode, Dr. Sherr board certified internal medicine physician, hyperbaric oxygen specialist, and COO of Troscriptions breaks down everything you need to know about HBOT: how it works at the cellular level, which conditions it treats, how to access it, and how to combine it with cutting-edge molecules like methylene blue for maximum results. Whether you're dealing with brain fog, chronic fatigue, long COVID, TBI, or simply want to optimize your health and slow down aging this episode is for you.

In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty, they dive deep into the specific biology of preconception, pregnancy, and pediatric health optimization. Moving beyond typical disease management, they explore how to foster both psychological and cellular safety across the entire family unit. Join us as we delve into: The Masterclass Blueprint: Navigating the fastest period of human growth and biological wiring from preconception to age 12. The Energy Demands of Fertility: Why oocytes (eggs) and reproductive organs hold the highest mitochondrial density per cell in the body. Pediatric Shifts: Addressing modern rises in childhood insomnia, allergies, immune dysregulation, and pediatric autoimmunity through an exposomic lens. The Testing Trap: Why traditional adult lab testing templates aren't always required—or appropriate—for resilient, self-correcting children. Family Attunement & Nervous System Regulation: Understanding why adult parent optimization directly dictates child behavior, sleep quality, and home environment stressors. This episode is for you if: You are a parent looking to leverage practical bioenergetics, chronobiology, and clean exposomics for your household. You are preparing for pregnancy and want to optimize cellular health during the critical 90-day preconception timeline. Your child is struggling with modern issues like appetite dysregulation, blue-light toxicity, or environmental heavy metal burden. You want a sustainable template for family health that values parent self-care over self-sacrifice. You can also find this episode on… YouTube: https://youtu.be/WsvoFXcIuZ4 Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics  Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Dr. Deanna Minich is a nutrition scientist, author, and educator specializing in nutrition, circadian health, metabolism, and the connections between diet, lifestyle, and whole-body wellness. Show partners: LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Troscriptions - 10% off your first order by using the code "JESSE" at checkout Show notes: jessechappus.com/707

If you're eating well, exercising, taking supplements, and still don't feel like yourself, your nervous system may be stuck in survival mode. Most people assume low energy means they need more discipline, another supplement, or the latest health hack. But what if the real problem isn't effort at all? Studies estimate that over 70% of primary care visits are linked to stress-related disorders. At the same time, mitochondrial dysfunction is increasingly recognized as a contributor to fatigue, poor recovery, and reduced resilience.  In this episode of Uncover Your Eyes, Dr. Meenal Agarwal sits down with Dr. Scott Sherr, a Physician who specializes in health optimization medicine. They explore the connection between chronic stress, nervous system dysregulation, and cellular energy production. Together, they discuss hyperbaric oxygen therapy, methylene blue, and practical strategies to improve recovery and performance.  In this episode, you'll uncover:

Our trusted source for Methylene Blue: https://www.troscriptions.com/muscle (10% off) Functional medicine Dr. Scott Sherr joins Ben Pakulski to break down methylene blue — the 100-year-old compound that's become one of Ben's favorite tools for energy, focus, and endurance. Dr. Sherr explains how it reboots mitochondrial function in days (not months), how one endurance athlete he coaches cut three hours off a 100-mile race, and how to dose it safely. Plus the warning most people never hear: why the majority of methylene blue sold online is contaminated, and what to look for in a clean source. In this episode… → The bottleneck behind almost everything (energy, brain, recovery, fat loss)  → The four complexes of your electron transport chain, and where most men are blocked → Why statins might be quietly trashing the system you're trying to optimize → Which molecule does "ninja moves" for mitochondrial dysfunction → The exact dosing protocol Scott uses for performance, travel, sauna, and endurance About Dr. Sherr Dr. Scott Sherr is a board-certified Internal Medicine physician and one of the leading clinical voices on methylene blue and mitochondrial medicine. He is certified to practice Health Optimization Medicine (HOMe) — a root-cause framework he helped bring to the U.S. as founder of HOMe-SF, the country's first HOMe clinic — and is a specialist in Hyperbaric Oxygen Therapy (HBOT). He is the COO of Troscriptions (the precision-dosed troche company behind Just Blue, Tro+ Blue, and Blue Cannatine) and its parent, Smarter Not Harder, as well as COO of the nonprofit Health Optimization Medicine and Practice (HOMe/HOPe) USA, which trains doctors to detect and correct the root causes of health. He is also co-founder of OneBase Health, an integrative HBOT ecosystem. He has consulted for Upgrade Labs, Remedy Place, and other wellness ventures, and lives in Louisville, CO with his wife and four kids. Key credentials Board-Certified Internal Medicine Physician  Hyperbaric Oxygen Therapy (HBOT) specialist  COO, Troscriptions / Smarter Not Harder COO, Health Optimization Medicine & Practice (HOMe/HOPe) USA  Co-Founder, OneBase Health  Connect with Dr. Sherr Instagram: https://www.instagram.com/drscottsherr/ LinkedIn: https://www.linkedin.com/in/drsherr Website: https://drscottsherr.com/ Work with Muscle Intelligence The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply/ If you're interested in working with Ben. ben@muscleintelligence.com Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter

We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling. In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions. This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition. If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on. In this episode, we cover: Why brain fog is such a common midlife complaint What mitochondria actually are and why they matter for brain energy How estrogen loss may contribute to mitochondrial dysfunction How methylene blue may support mitochondria, energy production, and mental clarity The difference between low-dose and high-dose methylene blue use The truth about methylene blue and nitric oxide Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain How stress and sympathetic overload affect mood, sleep, and focus Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support Why HRT may help, but may not be the whole story for every woman Who this episode is for This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms.   Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He's the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients. Troscriptions: Use coupon code HORMONE for 10% off your order.     Sponsors Get 15% off Masszymes at bioptimizers.com/hormone  Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back!  Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system.

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization and the "more is better" mentality. They explore real clinical case studies of patients who inadvertently damaged their health by blindly following supplement trends. Join us as we delve into: The dangers of over-supplementing with high-dose Fish Oil and Vitamin B6. How shifting to an "Omega-3 dominant" ratio can actually hinder your immune system's ability to heal injuries. Why you should treat metabolomic testing like the dashboard of a car to prevent the "check engine light" of chronic disease. How clinical metabolomics allows you to stop guessing and start subtracting unnecessary pills from your daily routine. This episode is for you if: You are experiencing wellness burnout and taking a massive handful of supplements every day without knowing if they are working. You want to understand the difference between being "fit" (e.g., running a marathon) and being truly cellularly "healthy." You are curious about functional testing and how it differs from the standard disease-focused bloodwork at a primary care clinic. You want a clear strategy to cut through social media influencer noise and build a foundational, personalized health protocol. You can also find this episode on… YouTube: https://youtu.be/WSNOBi1e7WY  Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

For this week's PicklePod, we're joined by two of the most exciting young stars in pickleball: Hayden Patriquin and Gabe Tardio of the St. Louis Shock. We dive into everything from Shock team culture and MLP pressure to why Gabe ignored traditional pickleball advice and built his own game from scratch. Hayden also opens up about his on-court personality, social media backlash, and finding the balance between playing with emotion and staying under control. We also get into: - The “Shock are chokers” debate - Why Hayden might have the highest ceiling in pickleball - What makes Ben Johns so difficult to beat - Signature shots and unique techniques - The future of pickleball strategy - Gambling stories, trash talk, and complete chaos This episode goes all over the place in the best way possible. One minute we're breaking down elite strategy and the next we're talking baccarat, sleep habits, and why nobody actually knows the “right” way to play pickleball. Subscribe and let us know: Who has the highest ceiling in pickleball right now?

Dr. Bill Harris is a leading omega-3 researcher, founder of the Omega-3 Index, and co-founder of OmegaQuant, specializing in fatty acids, cardiovascular health, and nutrition science. Show partners: Troscriptions - 10% off your first order by using the code "JESSE" at checkout Ketone-IQ - Save 30% off your subscription order plus youʼll get a free gift with your second shipment by using this link LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Show notes: jessechappus.com/705

This week I interviewed Jay Campbell. Jay is a 5x international best-selling author, men's physique champion, and the Owner and Co-Founder of BioLongevity Labs. Widely recognized as a leading expert on hormonal optimization, therapeutic peptides, and biohacking, Jay helps individuals break free from the failing “sick care” system and take control of their health. We discussed the right and wrong way to use peptides along with: - What is GLP-1, 2 and 3 - How can someone start using peptides to optimize their health -  What's the fastest, healthiest way to lose those extra 10-15 poundsand his one tip to get your body back to what it once was!Connect with Jay:https://biolongevitylabs.com/https://jaycampbell.com/----------How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/FREE Nutrition Cheatsheets:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the science and clinical application of creatine. Moving beyond its reputation as just a performance supplement for "gym bros," Boomer Anderson, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Ted Achacoso break down how creatine functions as a critical cellular battery buffer. Join us as we delve into: How creatine bypasses the "methylation tax" by saving the body from depleting SAMe reserves to produce energy. Why muscle is a metabolic determinant of resilience and not just a cosmetic feature. The evolutionary mismatch that increases our cellular energy demands due to a highly sympathetic, stressed lifestyle. The role of creatine in brain health is particularly important for supporting working memory, mitigating cognitive fatigue, and protecting against excitotoxicity. This episode is for you if: You are curious about how to support your body's cellular energy and mitochondrial function. You follow a vegetarian or plant-based diet and want to understand your specific creatine supplementation needs. You want to understand the difference between maintaining muscle for aesthetic reasons versus metabolic health. You are looking for strategies to mitigate mental fatigue and sleep deprivation. You can also find this episode on... YouTube: https://youtu.be/R4x9tu56FXg  Find more from Health Optimization Medicine and Practice (HOMeHOPe):Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics  Find more from Troscriptions:Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/  Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you've been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You're not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn't Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

The guys break down the top 5 data-backed reasons people actually stay consistent with fitness, and why aesthetics (the most common motivation) is actually the weakest long-term motivator. They also cover why exercise outperforms antidepressants and talk therapy for depression and anxiety, a study on which professions age people's faces fastest, and an income-vs-attractiveness study showing women are 1,000x more sensitive to a man's earnings when rating attraction. Plus: Adam's Catrina gets mistaken for a much younger woman at the gym, Justin's son wins his gymnastics competition after seeing a sports psychologist, and the Push Scroll app that locks your social media behind squats and push-ups. Then it's live coaching calls with Lindsay, Sandy, Maggie, and Nikki. SPONSORS Joovv — https://joovv.com/mindpump Code: MINDPUMP — $50 off your first purchase Troscriptions — https://troscriptions.com/MINDPUMP Code: MINDPUMP — 10% off your first order Seed Daily Synbiotic — https://seed.com/mindpump Code: 25MINDPUMP — 25% off your first month MAPS 15 BOGO — https://maps15bogo.com Buy 1 get 1 FREE — limited time LINKS Submit a live caller question: https://mplivecaller.com Mind Pump Fitness Coaching: https://mindpumpfitnesscoaching.com Mind Pump Store: https://mindpumpstore.com Instagram: @mindpumpmedia   0:00 - Intro, sponsors & shirt giveaway 2:36 - Top 5 reasons people stay consistent — #1: Enjoyment 11:18 - #2: Mental health — exercise vs. therapy and medication for depression & anxiety 20:23 - #3: Physical health & pain relief — the real fountain of youth 23:30 - #4: Aesthetics — why it's the least reliable long-term motivator 25:21 - #5: Community — why Gen Z now ranks the gym as the #1 social venue 30:01 - Which occupation ages your face the fastest? (Study breakdown) 31:14 - Katrina overheard at the gym — "figures he'd date someone younger" 35:04 - Income vs. attractiveness study — women 1,000x more sensitive to men's earnings 43:10 - Justin's son wins first place + skateboarding kids try to punk Justin 50:27 - Troscriptions True Moon — cordyceps deep dive (75mg vs. typical 2–15mg) 52:53 - Push Scroll app — earn social media time by doing squats and push-ups 56:03 - Caller: Lindsay (NC) — Social worker, almost 50, wants to become a personal trainer 1:14:14 - Caller: Sandy (UT) — 73-year-old with MS, lifting 3x/week, asks about body fat 1:24:01 - Caller: Maggie (BC) — Perimenopausal, wants to run a half marathon while building muscle 1:38:30 - Caller: Nikki (ON) — Overtrained, low libido, gets offered 3 free months of coaching  

In this episode of the HOMe Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz explore a foundational principle of Health Optimization Medicine: What's toxic to the cell is toxic to every organ. Through real clinical cases — including mercury toxicity, arsenic exposure, and environmental toxin accumulation — the team reveals how modern medicine often misses the root cause of disease by focusing on isolated organ systems instead of cellular function. From chronic low-level toxin exposure to acute breakdown events, this episode highlights how toxins disrupt mitochondrial energy production, leading to widespread dysfunction across the body. Most importantly, the conversation emphasizes the role of metabolomics in identifying these hidden stressors early — before they manifest as disease. Join us as we delve into: • Why toxins affect every organ through the cell • A real case of mercury toxicity missed by multiple specialists • How chronic exposure becomes acute illness • Why traditional medicine misses root causes • The role of mitochondria in energy production and health • How metabolomics detects early toxicity and dysfunction This episode is for you if: • You want to understand the root cause of chronic illness • You're exposed to environmental toxins (food, water, air) • You're interested in preventative and optimization-based medicine • You want to take a proactive approach to long-term health You can also find this episode on…Youtube: https://youtu.be/CMhFC5IUKl0 Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products 

Dr. Andrew Koutnik is an award-winning scientist committed to producing and translating cutting-edge research into solutions for health. Show partners: Ketone-IQ - Save 30% off your subscription order plus youʼll get a free gift with your second shipment by using this link Troscriptions - 10% off your first order by using the code "JESSE" at checkout Show notes: https://jessechappus.com/703

This week I interviewed the founder of Body Systems - Ben Brown.  Body Systems is a global health and nutrition coaching company behind the revolutionary PrimeFit OS™, a system that has helped clients lose over 15,000 pounds and reclaim their lives. With more than two decades of experience, he has coached Fortune 500 executives, professional athletes, along with thousands of driven men and women seeking sustainable health solutions. We discussed how different styles of eating work for different individuals along with:  - Problems with too much restriction - Importance of Accountability - Taking Willpower out of the Equationand his one tip to get your body back to what it once was!Connect with Ben: https://bodysystems.com/-----------How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/FREE Nutrition Cheatsheets:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min------------Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with JJ Virgin — nutrition expert, bestselling author, and founder of the Health Business Growth Collective — to explore how healthcare practitioners can build trust, authority, and impact in today's rapidly evolving landscape. With the rise of AI and what JJ calls a "trust recession," the traditional ways of building a practice are no longer enough. Instead, practitioners must learn how to stand out as a trusted authority — combining credibility, authenticity, and real-world proof. JJ breaks down her powerful "Trusted Authority Framework," explaining how clinicians can differentiate themselves, connect with patients, and grow their influence without becoming influencers. This episode is a must-listen for practitioners looking to grow, scale, and future-proof their practice in the age of AI. Join us as we delve into: The "Trust Recession" and why it's reshaping healthcare The difference between being an influencer vs a trusted authority Why vulnerability and storytelling build trust faster than credentials How to develop a contrarian stance that defines your expertise The power of patient stories as proof (and why they outperform credentials) Why most practitioners struggle with imposter syndrome — and how to reframe it This episode is for you if: You're a practitioner looking to grow your practice You want to build authority without becoming a social media influencer You're navigating AI, personal branding, and patient trust You want to stand out in a crowded health and wellness space You can also find this episode on… YouTube: https://youtu.be/rmyDXStM_Dk Find more from JJ Virgin Website: https://jjvirgin.com Health Business Growth Collective: https://hbgc.co Instagram: https://www.instagram.com/jj.virgin/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

You think your motivation is the reason you keep showing up… but it might actually be the exact reason you keep quitting. Sal, Adam, and Justin break down why basing your entire fitness identity around how you LOOK is a ticking time bomb… and why the most disciplined, hardest working people are often the first ones to burn out and walk away. This is the episode that changes how you think about fitness forever. The guys go deep on what it actually means to have a HEALTHY relationship with fitness… one that carries you through surgeries, stress, new babies, bad sleep, and every curveball life throws at you. They share real client stories, including a woman who went through surgery and major life stress and almost couldn't see the massive progress she had made because she was so locked in on the wrong metrics. Sound familiar? It should. Because this is almost EVERYONE. Plus… Sal shares the gorilla suit psychology experiment that perfectly explains why fixating on appearance causes you to completely miss all the other incredible benefits fitness is giving you. And Adam opens up about the pivotal moment he finally gave himself permission to just go do four sets of squats and leave… and why that single shift made him look BETTER than his peak shape in his mid twenties. This is the mindset upgrade your fitness journey has been missing. Live caller coaching follows the intro for even more real world application. MAPS PPL SALE ! mapsppl.com - code for 40% off is "PPL" Included:  Building Diet Guide & Supplement Guide. At-Home Version (Dumbbells only).  Separate programs for Male & Female Sponsors: Legion ⇨⇨go to buylegion.com/mindpump Code "MINDPUMP" for buy one, get one 50% off for new customers, and 20% cash back for returning customers! Troscriptions ⇨⇨go to troscriptions.com/MINDPUMP Use code "MINDPUMP" for 10% off your first order  KION ⇨⇨go to getkion.com/mindpump 20% off, No code needed automatically applied at check out!

In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Ted Achacoso, Dr. Scott Sherr, and Jodi Duval explore mental health through the lens of health optimization medicine. Rather than viewing mental health as a set of diagnoses, the conversation reframes it as a function of cellular health — where brain function is driven by mitochondrial performance, inflammation, nutrient status, and environmental inputs. From neurotransmitter imbalances to brain inflammation and the gut-brain-microbiome axis, this episode breaks down how modern stressors, lifestyle, and environment impact mental health at the cellular level. Most importantly, the team explains why true mental health optimization must begin with optimizing the health of the cell. Join us as we delve into: • Why mental health should be viewed at the cellular level • The role of mitochondria in brain energy and signaling • Brain inflammation and its impact on mood and cognition • The gut-brain-microbiome axis and neurotransmitter production • Why stress, sleep, and environment drive mental health outcomes This episode is for you if: • You struggle with brain fog, anxiety, or low mood • You want a deeper, root-cause understanding of mental health • You're a practitioner looking beyond traditional psychiatry • You want to optimize cognitive performance and resilience You can also find this episode on…YouTube: https://youtu.be/5xqAzkMUpBs Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Dr. David Unwin is a UK-based physician and leading researcher in low-carbohydrate medicine, known for helping patients reverse type 2 diabetes and metabolic disease through dietary change. Show partners: Troscriptions - 10% off your first order by using the code "JESSE" at checkout LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Ketone-IQ - Save 30% off your subscription order plus youʼll get a free gift with your second shipment by using this link Show notes: https://jessechappus.com/701

PicklePod 2.0 is presented by Marek Health. Use our code THEDINK for 10% off your $299 Intake Assessment at https://MarekHealth.com/ This week on the PicklePod, everything goes off the rails. From controversial line calls at the US Open to a shocking paddle-toss disqualification in Sacramento, this might be the most chaotic week in pro pickleball yet. We break down: - The “hooking” controversy everyone is talking about - Why some calls went viral… and others didn't - The paddle toss DQ that has players divided - Anna Leigh Waters & the Pickleball Slam fallout - Jack Sock's rise (and what's next) - Federico's dominance in men's singles - Nico's silver medal run (and what went wrong

Dr. Scott Sherr is a clinician, hyperbaric medicine specialist, co-founder of Troscriptions, and one of the founding faculty of the Health Optimization Medicine and Practice nonprofit — and in this return episode, he comes with a very different perspective than his first appearance. What changed? He stopped putting everyone in the chamber. In this conversation, Scott and Freddie unpack the two hyperbaric chamber deaths that shook the industry in 2025 — what actually went wrong, what safety standards clinics and home users are missing, and why a sympathetically dominant nervous system may render even the best biohacking tools completely ineffective. From there they go deep on mitochondrial function as the master upstream driver of energy, detox, digestion, healing, and longevity — and why most people need to subtractbefore they can optimize. The second half of this episode is a complete masterclass on methylene blue — what it actually does at the mitochondrial level, how to find your ideal dose (hint: you'll know within three to five days), why 94% of American adults are metabolically compromised enough to benefit from it, and how one ultramarathoner shaved three hours off his Leadville 100 finish time using it strategically. Scott and Freddie also tackle epigenetic age testing, immunosenescence, the dopamine-draining effects of smartphones on libido and focus, and why screen time may be the most underrated threat to your nervous system recovery. Plus — a full breakdown of the Troscriptions product suite: TruCalm, TruZ, TruImmune, and methylene blue's role in each.Episode Highlights [04:27] – Dr. Scott explains how his work now spans clinical care, practitioner training, and product development [06:35] – Why mitochondrial function has become the foundation of his approach to health and recovery [07:42] – What likely caused recent hyperbaric chamber accidents and why safety protocols matter [13:12] – Why stacking devices inside a chamber creates unnecessary risk [15:16] – The problem with influencer protocols and overcomplicating health routines [18:52] – Soft-shell vs. hard-shell chambers and how pressure impacts oxidative stress [22:42] – A practical framework for intensive vs. maintenance hyperbaric use [27:59] – Why direct mitochondrial testing is limited and how metabolomics fills the gap [29:55] – Common signs of mitochondrial dysfunction, from brain fog to poor recovery [35:53] – Dr. Scott revisits methylene blue and challenges common misconceptions [39:28] – Why most people may benefit from mitochondrial support despite “not being sick” [41:44] – How to think about dosing and what a proper response should feel like [44:04] – The role of sympathetic dominance in blocking healing and recovery [46:04] – Why longevity metrics need context beyond just improving numbers [50:16] – How screen time and dopamine overload impact energy, libido, and focus [53:08] – The expanding Troscriptions product line and the goal of needing less over time Scott's First Episode: https://open.spotify.com/episode/42vjXWQ9HAFqOd2avJsj6n?si=76da7d2114694e6a   Links & Resources Connect with Dr. Scott Sherr: https://www.instagram.com/drscottsherr/ Buy Troscriptions: https://troscriptions.com/?rfsn=9066612.3f3859&utm_source=refersion&utm_medium=affiliate&utm_campaign=9066612.3f3859 Use Code: BeautifullyBroken Silver Biotics: https://bit.ly/3JnxyDD Use Code: beautifullybroken   CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Boomer Anderson is not your typical health guru—he's a former investment banker turned health optimization pioneer who got the wake-up call of a lifetime when he was diagnosed with cardiovascular disease at just 30 years old. Instead of accepting the standard “take a pill and come back in ten years” approach, Boomer went all-in on understanding what true health actually means. Today he's the CEO of Troscriptions, building science-backed solutions for stress, sleep, focus, and immune function, and the driving force behind Health Optimization Medicine and Practice (HOMe HOPe), a nonprofit that trains doctors worldwide to optimize for health rather than just manage disease. With a background that spans global finance, over 65 countries, and a relentless passion for challenging the process, Boomer brings the kind of real-world, research-backed insights that every entrepreneur and leader needs to hear.Takeaways:Your Stress Bucket Is Probably Already Broken: Boomer introduces the concept of the stress bucket—a container for all the stress in your life from work, relationships, environment, and yes, even exercise. When that bucket overflows, what you think is helping you (like intense workouts) can actually accelerate damage. Leaders need to audit their total stress load before adding more to the pile.Sleep Is the ROI Play You're Ignoring: Getting just six hours of sleep has the same cognitive impact as drinking two to three beers. Pull an all-nighter and you're operating like you've had ten to twelve. For entrepreneurs whose greatest asset is their brain, sacrificing sleep is literally leaving performance and money on the table.Health Starts at the Cellular Level: Boomer breaks down his framework that true health is more than the absence of disease—it's about getting your body's basic cell optimized and balanced. When you bring biomarkers like hormones and nutrients back to their evolutionary optimal levels (ages 21 to 30), the symptoms that plague most executives—brain fog, low energy, poor sleep—begin to fall away.Sound Bytes:“The through line for everything that I do is challenging the process.”“Getting six hours of sleep a night versus eight is the cognitive impact of drinking two to three beers. An all-nighter is the equivalent of drinking ten to twelve.”“Your day doesn't start with when you wake up in your morning routine. It actually starts with your evening routine.”Connect & Discover Boomer:Instagram: @boomersnhWebsite: troscriptions.comX: @boomersnhLinkedIn: @boomerandersonNonprofit: homehope.orgYouTube: Troscriptions

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, and Jodi Duval as they break down one of the most important frameworks in Health Optimization Medicine — the Cell Danger Response (CDR). Originally developed by Dr. Robert Naviaux, the Cell Danger Response explains how cells respond to threat, adapt for survival, and either resolve or become "stuck" — leading to chronic disease. This episode walks through the three stages of the CDR, how mitochondria act as both sensors and signaling hubs, and why many modern conditions — from inflammation to chronic illness — are actually stalled healing processes. Most importantly, the team explains how clinicians and individuals can identify where the body is "stuck" and what to do (and NOT do) to support proper resolution. Join us as we delve into: What the Cell Danger Response (CDR) is and why it matters The 3 stages: defense, repair, and resolution How mitochondria act as sensors — not just energy producers Why inflammation is a protective response, not the problem How chronic disease reflects a "stalled" healing process This episode is for you if: You're dealing with chronic inflammation or unresolved health issues You want to understand the root cause of disease beyond symptoms You're a practitioner looking for a systems-based framework You want to optimize health by working with your biology, not against it You can also find this episode on… YouTube: https://youtu.be/NWEq32hlZrE Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/  Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Want the mental edge Ben trains with? Head to troscriptions.com and use code MUSCLE for 10% off Troscriptions.com/muscle   Curious about the REM and Boost patches Ben is testing? Head to superpatch.com to try them out   Join The #1 Online Community for Men Over 35 to Transform Their Bodies and Reclaim Their Vitality. muscleintelligence.com/VIPmembership   Most people are working hard in the gym and getting it wrong. In this episode, Ben Pakulski breaks down the real building block of muscle growth, and it starts with a single inch of a rep. Ben reveals why counting reps is one of the biggest mistakes in training, how to maximize tension in the exact range that matters most, why tightness signals weakness, and why breathing may be the most overlooked foundation in all of fitness. If your results have stalled or you've been putting in effort without answers, this episode will change how you train permanently. Do not skip this one. 5 Bullet Points: Muscles respond to tension and fatigue, not rep count One inch of a rep can transform your training Tightness in your body signals weakness, not age Diaphragmatic breathing is the foundation of every workout Path and profile determine which muscles actually work Call To Actions: The proven system 1000+ men use to stay lean, strong, clear, and capable. https://www.muscleintelligence.com/apply/   If you're interested in working with Ben. ben@muscleintelligence.com   Join 200,000 men in their prime, reading our weekly newsletter: http://muscleintelligence.com/newsletter   Unlock Your Full Muscle Building Potential With Our Complete Training Guides: https://go.muscleintelligence.com/bodypart/   Hypertrophy Execution Mastery: The most comprehensive MI40 muscle-building program EVER! https://hypertrophymastery.com/   Whenever you're ready... here are 3 ways we can help you look, feel and perform at your best:   1. Grab a free copy of 1 of our BRAND NEW Peak Performance Protocols. This is for high performers looking to 10x their training and nutrition results by becoming 10x more effective. Click here - https://go.muscleintelligence.com/high-performance-executive-report/   2. Join the Muscle Intelligence Community and connect with other men like you who want to uplevel their health and fitness. It's our new Facebook group where I coach members live, share what's working with my private clients and announce tickets to my upcoming trainings and events. Click here - https://www.muscleintelligence.com/community   3. Work with me 1-on-1 If you're a top performing executive or entrepreneur who wants a fully customized comprehensive health protocol and support from a team of world-class specialists, click here to speak with a member of my team to review all of your goals and options: https://www.muscleintelligence.com/apply?utm_campaign=YT About Ben Ben Pakulski is the Chief Performance Officer to elite executives, successful entrepreneurs, and top athletes.With over 25 years of experience, he coaches high achievers to build the physical, psychological, and metabolic resilience required to lead at the highest level. As the creator of the Muscle Intelligence framework, Ben specializes in aligning biology and behavior to drive sustained peak performance. His mission is to redefine what's possible for people in their prime and push the boundaries of human potential.

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Dr. Autumn Smith is the co-founder of Paleovalley and Wild Pastures, a functional nutrition expert, and a leading voice in regenerative food and metabolic health. Show partners: Ketone-IQ - Save 30% off your subscription order plus youʼll get a free gift with your second shipment by using this link Troscriptions - 10% off your first order by using the code "JESSE" at checkout Show notes: https://jessechappus.com/699

If you're only lifting weights to build muscle… you might be leaving serious gains on the table. In this episode, the guys break down why strength training alone isn't always enough, and how adding the right forms of cardio, mobility work, recovery, and even modalities like Pilates can actually improve muscle growth, performance, and longevity. They explain how your "gas tank" (cardiovascular fitness) can limit your strength, why mobility unlocks more muscle potential, and how tools like sauna use and recovery strategies can enhance results without overtraining. The conversation also expands into modern stress, community, and why human connection may be one of the most overlooked factors in overall health and resilience. Plus, they dive into new research on fish oil and mental health, and share some wild fitness and animal facts along the way.   The Spring Bundle: Symmetry ($187), Prime ($107), Advanced Training Techniques Guide ($47) all for $147 (over 50% off) mapsmarch.com This episode is brought to you by KION ! ⇨⇨go to ⁠getkion.com/mindpump⁠ 20% off, No code needed automatically applied at check out!   This episode is also brought to you by Troscriptions! ⇨⇨go to ⁠troscriptions.com/MINDPUMP⁠ Use code "MINDPUMP" for 10% off your first order   What does Seed Daily Synbiotic do for you? Supports benefits in and beyond the gut——yes, Seed will support ease of bloating, healthy regularity, but it will also support your gut barrier, skin health, heart health, and micronutrient synthesis. Note: Gut immune function is not "boosting the immune system." It is about supporting the 'cross talk' between your intestinal cells and your immune cells. ⁠seed.com/mindpump⁠ Code "20MINDPUMP" for 20% off your first month of Seed's Daily Synbiotic 00:00 Intro 00:39 Sponsors, Promotions & MAPS Bundle 01:55 You're Leaving Muscle Gains on the Table 06:01 How Cardio Actually Improves Strength & Performance 10:19 Using Cardio as a Strategic Tool (Not Constantly) 11:36 Mobility, Range of Motion & Unlocking More Muscle 14:39 Recovery Hacks: Massage, Sauna & Performance Boosters 17:06 Can Pilates Help Build Muscle? Programming for Goals 22:27 Fish Oil, Stress & Modern Health Problems 25:17 The Real Reason We're More Stressed Today (Community Loss) 33:08 Why Human Connection Matters More Than Fitness 45:16 Sleep, Supplements, Random Facts & Dad Life Stories

Neurologist Dr. Dale Bredesen shares clinical evidence that cognitive decline can be prevented — even reversed. Show partners:  LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Troscriptions - 10% off your first order by using the code "JESSE" at checkout Jaspr - Save $300 off your Jaspr air scrubber by using this link Show notes: https://jessechappus.com/697