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Researchers recently found underground passages hidden beneath old buildings, matching designs from da Vinci's mysterious drawings. These tunnels might have been escape routes, secret workshops, or even part of a hidden defense system. Some believe da Vinci planned them for royalty or military strategies, using his genius to create something way ahead of his time. Some of these tunnels were completely forgotten for centuries until experts finally linked them to his old sketches. Now, archaeologists are exploring deeper, hoping to uncover more of da Vinci's lost secrets! Credit: Xpo Factory / YouTube SPIETV / YouTube CC BY-SA 3.0 https://creativecommons.org/licenses/... Vis aerienne Luc Viatour: By Photography Luc Viatour, https://commons.wikimedia.org/w/index... Monumento di Ludovico e Beatrice: By Ugo franchini, https://commons.wikimedia.org/w/index... Santa Maria delle Grazie: By Marcin Białek, https://commons.wikimedia.org/w/index... CC BY-SA 4.0 https://creativecommons.org/licenses/... Calco statua funebre di Beatrice d'Este al Victoria: By Beaest, https://commons.wikimedia.org/w/index... Rocca Sforzesca di Imola: By Vanni Lazzari, https://commons.wikimedia.org/w/index... Leonardo Da Vinci Robot: By Leonardo3 - Mario Taddei, https://commons.wikimedia.org/w/index... Tomb of Beatrice d Este: By Roberto Ferrari - https://flic.kr/p/5Hvfox, CC BY-SA 2.0 https://creativecommons.org/licenses/..., https://commons.wikimedia.org/w/index... Animation is created by Bright Side. ---------------------------------------------------------------------------------------- Music from TheSoul Sound: https://thesoul-sound.com/ Check our Bright Side podcast on Spotify and leave a positive review! https://open.spotify.com/show/0hUkPxD... Subscribe to Bright Side: https://goo.gl/rQTJZz ---------------------------------------------------------------------------------------- Our Social Media: Facebook: / brightside Instagram: / brightside.official TikTok: https://www.tiktok.com/@brightside.of... Telegram: https://t.me/bright_side_official Stock materials (photos, footages and other): https://www.depositphotos.com https://www.shutterstock.com https://www.eastnews.ru ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me ---------------------------------------------------------------------------------------- This video is made for entertainment purposes. We do not make any warranties about the completeness, safety and reliability. Any action you take upon the information in this video is strictly at your own risk, and we will not be liable for any damages or losses. It is the viewer's responsibility to use judgement, care and precaution if you plan to replicate. Learn more about your ad choices. Visit megaphone.fm/adchoices
Het tech-jaar wordt traditiegetrouw afgetrapt met de CES, 's werelds grootste techbeurs in Las Vegas. Voor Bright vlogen Eric en Mark naar de woestijn, om de nieuwste gadgets te bekijken. Ze zagen heel veel AI, maar wel slimmer dan vorig jaar. En gelukkig zijn er ook nog genoeg andere gadgets om te bespreken.Veel AI weer op de CES, zoals in tv's en zelfs in wasmachines. Maar gelukkig ook genoeg ouderwets verrassende gadgets. Zo komt Ballie van Samsung eindelijk echt uit, net als de auto van Sony waar het jaren over gaat. Er zijn opvallende e-bikes, een high-tech parasol, een robotstofzuiger met een arm en een hele slimme batterij-lader. In deze aflevering komen ze allemaal voorbij.Sponsor:Ga naar Calco.nl/talent voor meer informatie over betaalde traineeships om je naar IT te laten omscholen: voor hbo- en wo-opgeleiden die hun IT-carrière willen starten.Tips uit deze aflevering:YouTube-kanaal: Epic Spaceman, die zelf vanuit prachtig geanimeerde 3D-omgevingen vertelt over wetenschap en het universum. De omgevingen helpen daar enorm bij, want zijn naast mooi ook heel illustratief.Waarschuwing: Squid Game seizoen 2 had eigenlijk langer moeten zijn. Er komt later dit jaar een seizoen 3, maar dat maakt het einde abrupter dan je misschien zou verwachten. Vandaar de waarschuwing: geniet ervan, maar wees niet teleurgesteld.Game: Monument Valley 3, voor Android en iOS. Alleen te spelen als je een Netflix-abonnement hebt, maar dan is het ook gewoon inbegrepen. Het is meer van Monument Valley en dat is helemaal fijn. De eerste twee Monument Valley-games zijn trouwens ook gratis te spelen voor Netflix-abonnees.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Hoe lang gaat januari duren? Voor Malou was het een lange dag in een ernstig lastige positie en Tatjana drinkt tegenwoordig alleen nog maar champagne in elektrische auto's. We nemen het thema pleasen onder de loep, omdat een luisteraar dat vroeg, dus dat is pleasend - maar dat zijn we niet. Over mails van Malou en basic bitches. Een lieve levensvraag met een onmogelijke opgave om die te beantwoorden.
Ook deze week hebben we weer een gast: Niels van Straaten, bekend van het Instagram-account AppleDsign. We kijken met Niels samen terug op de hoogte- en dieptepunten van Apple in 2024.Verder: brain rot is het woord van het jaar, PlayStation is jarig en viert dat op een leuke manier, er zijn zorgen om de Sonos-app, Videoland doet het goed, en Bright Magazine komt weer terug!Sponsor:Ga naar Calco.nl/talent voor meer informatie over betaalde traineeships om je naar IT te laten omscholen: voor hbo- en wo-opgeleiden die hun IT-carrière willen starten.Tips uit deze aflevering:iPhone-tip: gooi een mp3-tje in de Notities-app op je iPhone, iPad of Mac, en je krijgt er automatisch een transcript van. Wel alleen in het Engels, maar toch verdraaid handig.Serie: Skeleton Crew op Disney+. Onze collega Peter bekeek de eerste drie afleveringen al en omschrijft het als Star Wars meets The Goonies. Spielberg dus, met een mysterieuze rol voor Jude Law. Er staat nu twee afleveringen klaar, het seizoen heeft er acht in totaal.Game: Animal Crossing Pocket Camp is er nu als niet-hebberige versie. De game verscheen ooorspronkelijk eind 2017 voor smartphones en tablets. Nintendo probeerde met de game ook een graantje mee te pikken van de free-to-play hype, waarbij je een game gratis kan spelen, maar wordt verleid om te betalen om verder te komen of meer items te krijgen. Die versie van de game sloot eind november: de servers zijn dicht, er kunnen geen aankopen worden gedaan. Nu is er Pocket Camp Complete, waarbij je eenmalig betaalt en daarna de hele game hebt, zonder die free-to–play onzin. Tot eind januari betaal je 10 euro voor de game, daarna het dubbele. Je voortgang in de game kan je meenemen, en ook nieuw: je kan ontwerpen uit Animal Crossing New Horizons voor de Switch overzetten naar de mobiele game.Productiviteit: Gebruik eens een notitieboekje – oldskool. In plaats van te zoeken naar dé to-do-app, kun je je taken ook gewoon ouderwets opschrijven. En verdomd, dan komt het wel echt een stuk beter binnen.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Malou staat in een lingeriewinkel en vraagt zich af of de vrouw van Rinse ook wel eens lingerie draagt en Tatjana heeft op een miraculeuze manier haar kaak op slot ge?????zet
Pieter Zwart, eindbaas van Coolblue, is te gast in Poki. Klaar voor de volgende stap in de IT? Meld je dan vandaag nog aan bij Calco via calco.nlMeer grip op je bedrijf? Met Teamleader Focus krijg je het voor elkaar. Ga naar focusopjebedrijf.nl en start vandaag nog met een gratis proefperiode van 14 dagen.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Per riascoltare Considera l'armadillo noi e altri animali che oggi ha ospitato Domenico Aiello di @Wwf per parlare di emergenza PSA e della richiesta di @wwf Lombardia di sospensione della mobilità venatoria, ma anche di galletto impiccato nella scuola per l'infanzia a Calco e di @enpa, di @oipa e le perplessità sul nome indicato al benessere animale nella Commissione Europea. A cura di Cecilia Di Lieto.
Ga voor de shownotes en het transcript naar damnhoney.nl/ruimteDAMN, HONEY wordt gemaakt door Marie Lotte Hagen en Nydia van VoorthuizenDeze aflevering wordt gesponsord door Calco en Independer.CalcoStart het IT traineeship van Calco en geef je loopbaan een boost! Ga naar Calco.nlIndependerEven Independeren, daar word je altijd wijzer van. Ga naar Independer.nleditwerk: Daniël van de Poppe jingles: Lucas de Gier website: Liesbeth Smit DAMN, HONEY is onderdeel van Dag & Nacht Media. Heb je interesse om te adverteren in deze podcast? Neem dan contact op met Dag en Nacht Media via adverteren@dagennacht.nlZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Tatjana is niet te stoppen en haar buikgriep ook niet. Het is een aflevering met emmer op schoot. Malou heeft een kort lontje en huilt bij discutabele reality-televisie. We sluiten af met het thema afsluiten, want hoe doe je dat, eindigen? Verder een mededeling zonder boodschap en tot de 19e. Of…………….
Ga voor de shownotes en het transcript naar damnhoney.nl/uitvaartenDAMN, HONEY wordt gemaakt door Marie Lotte Hagen en Nydia van VoorthuizenDeze aflevering wordt gesponsord door Calco en Blossom BooksCalcoStart het IT traineeship van Calco en geef je loopbaan een boost! Meer weten? Ga naar calco.nlBlossom BooksMet de kaartenset en het werkboek van And now what over de dood, bereid je je voor op het einde van het leven. Zolang de voorraad strekt koop je beide producten voor € 29,99 in plaats van € 49,98 op blossombooks.nleditwerk: Daniël van de Poppe jingles: Lucas de Gier website: Liesbeth Smit DAMN, HONEY is onderdeel van Dag & Nacht Media. Heb je interesse om te adverteren in deze podcast? Neem dan contact op met Dag en Nacht Media via adverteren@dagennacht.nlZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Er is een plekje in de hel gereserveerd voor een bepaald type mens met een bepaald type uitspraak. Malou kan niet meer praten en Tatjana is wakker genoeg om haar daarop te attenderen. Hoe is het om mee te doen aan reality-TV? Een van ons weet daar alles van. We kijken geen B&B Vol Liefde. Punt. Moeten wij weten. Punt. Een levensvraag en 100% orka-liefde!
Ga voor de shownotes en het transcript naar damnhoney.nl/aflevering-192DAMN, HONEY wordt gemaakt door Marie Lotte Hagen en Nydia van VoorthuizenDeze aflevering wordt gesponsord door Calco en Blossom Books.Start het IT traineeship van Calco en geef je loopbaan een boost! Ga naar calco.nlGa naar blossombooks.nl en gebruik de code DAMNHONEY10 voor 10% korting op alle Structuur Junkie-producten (geldig t/m 30 september 2024)editwerk: Daniël van de Poppe jingles: Lucas de Gier website: Liesbeth Smit DAMN, HONEY is onderdeel van Dag & Nacht Media. Heb je interesse om te adverteren in deze podcast? Neem dan contact op met Dag en Nacht Media via adverteren@dagennacht.nlZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Nella puntata di oggi ci addentreremo in un nuovo format: “IMPRESE D'ECCELLENZA - Le best practices di Plastica, Chimica, Farmaceutica”. Lo facciamo insieme all'azienda Charles River Laboratories che per l'occasione ci ha aperto le porte del loro stabilimento di Calco. A condurre il dialogo con Laura Zoia, Business Development Manager di Europa e Area del Golfo, abbiamo il Presidente della Categoria Merceologica Plastica, Chimica, Farmaceutica , Luigi Mario Ceruti Puricelli.
Hi My loves - this week's episode is a vulnerable and beautiful one. When I was a Freshman in high school at Portage Northern (whilst we lived in Kalamazoo, Michigan), I had a friend, who was in the grade above, she was my double's tennis partner the first year I was on the tennis team and the kindest soul. There was an instant connection and her passing broke so many of our hearts. I felt compelled to tell her story and her Mom was so gracious to give me the time to do so. "Kristina wrote in a 7th grade journal entry: “The only reason I even bother to tell my sad sob story is that someday the public might know what a teenage girl goes through. So as you know nice guys finish last….well it might as well be nice girls finish last, too”. Tragic as our story is to tell and live each day….I feel that there are things to be learned from Kristina's story. –Written in the hopes that no one else might ever have to awaken to a such a blustery snowy morning as we did." By Kristina's Mom: Michelle. To read more about Kristina's story, here is her Mom: Michelle's blog. Trigger Warning: This Episode Discusses Suicide This episode contains discussions about suicide that may be distressing to some listeners. If you or someone you know is struggling, please seek help. Here are some resources: National Suicide Prevention Lifeline (USA): Call 1-800-273-8255 or text "HELLO" to 741741. Samaritans (UK & Ireland): Call 116 123 or email jo@samaritans.org. Crisis Text Line: Text "HELLO" to 741741 (USA), 686868 (Canada), or 85258 (UK). Lifeline (Australia): Call 13 11 14. Remember, you are not alone. There is help available, and it is okay to reach out. ---------------- Link to sign up to the retreat is here - 2 SPOTS LEFT!!!!!! Stay connected with Magali here: InstagramSign up to the newsletter Podcast IGPodcast Youtube
Una cosa es traducir mal y la otra, calcar. Quédate y escucha esto que tela.Te invito a formar parte de La Comunidad ManchaPod:Espero tus audiocomentarios en https://www.speakpipe.com/manchapod y tus mensajes enTelegram (t.me/manchapod), donde podrás debatir con más escuchantes,Correo (manchapod@gmail.com)Mastodon (@manchapod@xerrem.xyz)Pixelfed (@manchapod@pixelfed.social)Twitter (@manchapod).Si te registras en la Asociación Podcast y usas el codigo JG6Q47 tendrás 5€ de descuento el primer año. http://asociacionpodcast.es/registrarse/socio/?coupon=JG6Q47Mecenas, Podcasts Amigos, Redes Colaboradoras:Víctor Gabriel "Argifonte"Toñi Martínez (Perretes)JoseteSergio MintauroVKLorena "Chispas"Álex (Puede Ser Una Charla Más PS1C+)Jose (Frente al Cliente)Iñaki Urdangarín (Restañando el Alma)Juanlu Uno y Sandra O (Estación Caladán)Dani Maverick (En Clave de Soundtrack y Podcaster al Desnudo)Zigor Vallejo (A Micro Descubierto)Carlos BissingerLa KompanioPaís InvisibleIlya HaykinsonEl Dr. Emilio Tejera PuenteLos Últimos de FEEDlipinasMoixa MentalEl ChiringuitoPodcast ForocochesY a ti, si decides hacerlo.
Veel Apple weer deze aflevering, want we bespreken de eerste reacties van Amerikaanse tech-reviewers op de Vision Pro. En we staan stil bij de controversiële aanpassingen die Apple doet aan de App Store in de EU. Verder: stilte op TikTok, nog meer gedoe bij fietsfabrikanten en Fitbits doen het al een maand niet meer.Sponsors:Ga naar Calco.nl voor meer informatie over betaalde traineeships om je naar IT te laten omscholen.Krijg 60 procent korting op een abonnement op Incogni, een dienst die je online-privacy verbetert. Incogni laat jouw gegevens verwijderen bij datahandelaren. Ga naar: incogni.com/brightTips uit deze aflevering:Podcast: De erfenis van Engel, over de meest beruchte camping van Nederland: Fort Oranje, van de omstreden Cees Engel (vader van Willem Engel). Een mooi stukje regiojournalistiek van BN De Stem en het AD.Podcast: De recap-show van de Nederlandse podcast Skip Intro op Patreon over de serie True Detective: Night Country. Voor 5 euro per maand krijg je extra afleveringen, waarin je bijvoorbeeld wordt gewezen op alle details in True Detective die je zelf misschien gemist hebt.Film: Argylle, de nieuwe film van Matthew Vaughn, onder meer bekend van de Kingsman-films. Argylle past in dat zelfde genre: ook spionage met veel geweld op een cartoon-achtige manier. De film neemt zichzelf geen seconde serieus en dat maakt het leuk. De insteek is: schrijfster van spionage-romans komt plots terecht in haar eigen boeken – meer moet je eigenlijk niet weten. Vanaf morgen in de bioscoop.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
In deze Knolcast is Tim, oftewel TowTruckTim (28) te gast. Hij vertelt met passie over zijn werk als berger, waarin hij soms met gevaar voor eigen leven auto's die in een ongeluk zitten van de weg te halen. Ook vertelt hij waarom hij dit werk doet en waarom hij dit deelt met duizenden mensen online. Dit en meer hoor je in deze Knolcast!Deze aflevering wordt mede mogelijk gemaakt door Calco. Ga naar www.calco.nl voor meer informatie.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Deze aflevering staat grotendeels in het teken van energie. Want we zijn vol in beweging, slimme gadgets veranderen de markt en daar praten we over met onze gast, Frank Breukelman van Zonneplan. Hij praat ons bij over de AI-batterij van Zonneplan die zichzelf terugverdient, en we doen een energie-deep-dive. Verder bespreken we de nieuwe Samsung Galaxy S24-toestellen en meer nieuws over batterijen, van in de Efteling tot in je fiets.Sponsors:Ga naar Calco.nl voor meer informatie over betaalde traineeships om je naar IT te laten omscholen.Claim je gratis ticket voor de Webwinkel Vakdagen op 23 en 24 januari in Jaarbeurs Utrecht.Tips uit deze aflevering:Podcast: De Groene Nerds, een podcast over slim omgaan met energie. Hun aanstaande aflevering staat zelfs in het teken van thuisbatterijen, voor als je door deze aflevering nieuwsgierig bent geworden.Serie: True Detective: Night Country, het vierde seizoen op HBO Max. Dit seizoen lijkt het niveau te evenaren van het veelgeprezen eerste seizoen met Matthew McConaughey en Woody Harrelson. Daarna zakte de misdaadserie wat weg. Dit keer speelt het verhaal zich af in Alaska waar acht wetenschappers zijn verdwenen. Met een nieuwe showrunner in plaats van Nic Pizzolatto, Issa Lopez, en ook vrouwelijke hoofdrolspelers dit keer: Jodie Foster en Kali Reis.Game: The Last of Us Part II Remastered voor de PlayStation 5. Kost 50 euro als je ‘m nog niet had, maar nog beter: 10 euro als je de game al wel hebt gekocht voor de PS4. Je krijgt natuurlijk verbeterde graphics: 4K, ray-tracing etc. Maar nog beter zijn de andere toevoegingen. Nieuw is de roguelike-modus No Return. Als een arcade-game vecht je jezelf dan door zombies, waarbij je zelf instelt hoe moeilijk alles is – je gaat door tot je dood bent, en je bekijkt daardoor de actie van de game op een heel andere manier, waardoor je in het verhaal misschien wat zelfverzekerder te werk gaat.Daarnaast zitten er drie deleted scenes in deze remaster. Drie levels dus, die de game uiteindelijk niet gehaald hebben. Die kan je alsnog spelen, maar ze zijn niet allemaal even af. Game-regisseur Neil Druckmann leidt de levels in en vertelt waarom ze de game niet gehaald hebben.Evenement: Games Done Quick, waarbij games met allerlei trucks en door bugs en glitches zo snel mogelijk worden uitgespeeld. Voor het goede doel, en met publiek en toelichting. Dat maakt dus veel vermakelijker en begrijpelijker dan de gemiddelde game-speedrun: die kunnen nog weleens ingewikkeld zijn. Games Done Quick doet het toch anders, met dit jaar bijvoorbeeld ook een hond.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Sven van de Wege, oftewel BlindWarriorSven (37) is een gepassioneerde gamer die bekend staat om zijn vaardigheden in vechtspellen, ondanks het feit dat hij blind is. Sven kon tot zijn 6e levensjaar zien maar verloor daarna zijn zicht... Hij heeft zich gespecialiseerd in het spelen van vecht games zoals Street Fighter. Sven vertelt in deze Knolcast over hoe hij blind is geworden, zijn persoonlijke leven en hoe het is om blind door het leven te gaan.Deze aflevering wordt mede mogelijk gemaakt door Calco. Ga naar www.calco.nl voor meer informatie.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Switch naar het meest innovatieve vakgebied wat er is: IT! Start het IT traineeship van Calco en geef je loopbaan een ongekende boost. Meer weten? Ga naar www.calco.nl.Deze week: Maxim en René als vertrouwd duo. Waggel als een pinguïn. Jan Smit heeft doorsneehoofd. Topjaar voor motorbranche. Links is luxe. Trad-woke in je broekje. Made in Africa nieuwste mode. Koop geen staatslot voor je familie. Roy Donders verkocht huispakken. Khalid voor het hekje. Geef alle slachtoffers hun poen. Luisteraars luisteren niet goed. Waterflesjes tsunamis van nanoplastic.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Hoe kun je een biologiedocent of verloskundige omscholen naar een -of Finance professional? Jan-Willem Gelderblom, topman van IT-detacheerder Calco is te gast in BNR Zakendoen. Macro met Mujagic Elke dag een intrigerende gedachtewisseling over de stand van de macro-economie. Op maandag en vrijdag gaat presentator Thomas van Zijl in gesprek met econoom Arnoud Boot, de rest van de week praat Van Zijl met econoom Edin Mujagić. Economenpanel Cao-lonen stegen vorig jaar gemiddeld met 6,1 procent. Maar de inflatie in december was 1,2 procent – een daling ten opzichte van november. En onder economen is de discussie losgebarsten: nemen de rentes in 2024 een duikvlucht? Dat en meer bespreken we om 11.10 in het economenpanel met Marijn Jongsma, macroredacteur bij het Financieele Dagblad; en Bas Jacobs, hoogleraar overheidsfinanciën. Luister l Economenpanel Contact & Abonneren BNR Zakendoen zendt elke werkdag live uit van 11:00 tot 13:30 uur. Je kunt de redactie bereiken via e-mail. Abonneren op de podcast van BNR Zakendoen kan via bnr.nl/zakendoen, of via Apple Podcast en Spotify. See omnystudio.com/listener for privacy information.
Hoe kun je een biologiedocent of verloskundige omscholen naar een IT of Finance professionel? Jan-Willem Gelderblom, topman van IT-detacheerder Calco is te gast in BNR Zakendoen Kan AI het personeelstekort in de IT en Finance sector verhelpen? Weten steeds meer vrouwen de IT sector te vinden? Is de buitenlandse stap van Calco een succes geworden? Over Calco Calco is een detacheerder voor de IT en Finance sector. Het bedrijf heeft klanten als Randstad en Heineken. Calco maakt onderdeel uit van de Britse investeerdersgroep Inflexion. Over Thomas van Zijl Thomas van Zijl is financieel journalist en presentator bij BNR. Hij presenteert dagelijks ‘BNR Zakendoen', het Nederlandse radioprogramma voor economisch nieuws en zakelijk inzicht, waar 'De top van Nederland' onderdeel van is. Ook is hij een van de makers van de podcast ‘Onder curatoren'. See omnystudio.com/listener for privacy information.
Ga voor de shownotes en het transcript naar damnhoney.nl/aflevering-165DAMN, HONEY wordt gemaakt door Marie Lotte Hagen en Nydia van VoorthuizenDeze aflevering wordt gesponsord door Calco. Start het IT traineeship van Calco en geef je loopbaan een ongekende boost. Meer weten? Ga naar www.calco.nleditwerk: Daniël van de Poppe jingles: Lucas de Gier website: Liesbeth Smit DAMN, HONEY is onderdeel van Dag & Nacht Media. Heb je interesse om te adverteren in deze podcast? Neem dan contact op met Dag en Nacht Media via adverteren@dagennacht.nlZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Ga voor de shownotes naar damnhoney.nl/aflevering-164Deze aflevering wordt gesponsord door MUBI en Calco. Volg @mubinederland op Instagram om op de hoogte te blijven van speciale screenings en events ennnn je krijg nu dus 30 dagen gratis - ga daarvoor naar www.mubi.com/damnhoneyStart het IT traineeship van Calco en geef je loopbaan een ongekende boost. Meer weten? Ga naar www.calco.nlDAMN, HONEY wordt gemaakt door Marie Lotte Hagen en Nydia van Voorthuizeneditwerk: Daniël van de Poppe jingles: Lucas de Gier website: Liesbeth Smit DAMN, HONEY is onderdeel van Dag & Nacht Media. Heb je interesse om te adverteren in deze podcast? Neem dan contact op met Dag en Nacht Media via adverteren@dagennacht.nlZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Elena Gijón reflexiona en 'Noticias mediodía' sobre la remodelación del Gobierno que ha realizado Pedro Sánchez tan solo 43 días después de haber nombrado el anterior.
Exclusieve, tijdelijke deal tot 9 januari: Ga naar https://nordvpn.com/wateenweek en krijg 4 extra maanden bij een 2-jaarabonnement + een Amazon.nl-cadeaubon tot € 30!Switch naar het meest innovatieve vakgebied wat er is: IT! Start het IT traineeship van Calco en geef je loopbaan een ongekende boost. Meer weten? Ga naar www.calco.nl.Maxim is terug uit tieten-Taiwan. Willem draagt onopvallend horloge. Billenknijper te zacht aangepakt. Ooginfecties nu in de mode. Thuiswonen is natuurlijk. Waar sta jij op de schaal van slachtoffer? Nieuwe wetten voor het plebs. Speel hard to get. René geslagen met ovenwant. Niemand wil geen plantaardige kroket. Varkensboeren stinkend rijk. Waarom zijn mensen... Vergeet Nieuwsuur, luister naar ons voor de enige waarheid.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Mix #1Andrea Laszlo De Simone / I nostri giorni / Ekler'O'ShockForever Pavot / Décalco / Born BadToni Esposito / L'eroe di plastica / Numero UnoQuasimodo / Esmeralda / Castel Le Hyporama : 18 ans c'est long, surtout pour un retour en petits chaussonsLe Tigre / I'm so excited / Le Tigre Mix #2Mauskovic Dance Band / People in the hall / Les Disques Bongo JoeVivian / I wish I could read the future / CiaoAlessandro Alessandroni / L'isola del piacere / Four FliesChassol / Manoeuvres sliding through the mess / Netflix Music L'Info du 20h : les anciens Daft toujours accros au dancefloor, mais les chorés ont un peu changéThomas Bangalter / Mythologies (Teaser) / Warner Classics Mix #3Rone / Parade / InfinéThe Juan Mac Lean / Happy house (Mark E remix of Matthew Dear vs Audion remix) / Vicious CharmSworn Virgins / The male man / DeeweeMarie Madeleine / Swimming pool / Ekler'O'Shock Le Fond Du Sac : à peine 3 ans que ce petit 45 tours cherche sa place dans Whizzz & LoveAki Kumar & Bollywood Band / Dum maaro dum / Needle To The Groove Mix #4Ice Spice / In ha mood / UMGRed Axes feat. Cohen / Bump city (Club version) / Nana DiscPatrick Cowley / Love me hot / Dark Entries
A Classic RISK! Singles episode! A story that CalCo first shared on the podcast in December of 2016 about being a victim of random gun violence. Support RISK! on Patreon at Patreon.com/RISKMake a one-time donation to RISK! at PayPal.me/RISKshowGet tickets to RISK! live shows at RISK-show.com/tourGet the RISK! book at TheRISKBook.comTake our storytelling classes at TheStoryStudio.orgHire Kevin Allison to make a personalized video at Cameo.com/TheKevinAllisonHire Kevin Allison as a coach at KevinAllison.com
Seemay Chou talks about the process of building a new research organization, ticks, hiring and managing entrepreneurial scientists, non-model organisms, institutional experiments and a lot more! Seemay is the co-founder and CEO of Arcadia Science — a research and development company focusing on underesearched areas in biology and specifically new organisms that haven't been traditionally studied in the lab. She's also the co-founder of Trove Biolabs — a startup focused on harnessing molecules in tick saliva for skin therapies and was previously an assistant professor at UCSF. She has thought deeply not just about scientific problems themselves, but the meta questions of how we can build better processes and institutions for discovery and invention. I hope you enjoy my conversation with Seemay Chou Links Seemay on Twitter (@seemaychou) Arcadia's Research Trove Biolabs Seemay's essay about building Arcadia Transcript [00:02:02] Ben: So since a lot of our conversation is going to be about it how do you describe Arcadia to a smart well-read person who has never actually heard of it before? [00:02:12] Seemay: Okay. I, I actually don't have a singular answer to this smart and educated in what realm. [00:02:19] Ben: oh, good question. Let's assume they have taken some undergraduate science classes, but perhaps are not deeply enmeshed in, in academia. So, so like, [00:02:31] Seemay: enmeshed in the meta science community.[00:02:35] [00:02:35] Ben: No, no, no, no, but they've, they, they, they, they they're aware that it's a thing, but [00:02:40] Seemay: Yeah. Okay. So for that person, I would say we're a research and development company that is interested in thinking about how we explore under researched areas in biology, new organisms that haven't been traditionally studied in the lab. And we're thinking from first principal polls about all the different ways we can structure the organization around this to also yield outcomes around innovation and commercialization. [00:03:07] Ben: Nice. And how would you describe it to someone who is enmeshed in the, the meta science community? [00:03:13] Seemay: In the meta science community, I would, I would say Arcadias are meta science experiment on how we enable more science in the realm of discovery, exploration and innovation. And it's, you know, that that's where I would start. And then there's so much more that we could click into on that. Right. [00:03:31] Ben: And we will, we will absolutely do that. But before we get there I'm actually really [00:03:35] interested in, in Arcadia's backstory. Cuz cuz when we met, I feel like you were already , well down the, the path of spinning it up. So what's, there's, there's always a good story there. What made you wanna go do this crazy thing? [00:03:47] Seemay: So, so the backstory of Arcadia is actually trove. Soro was my first startup that I spun out together with my co-founder of Kira post. started from a point of frustration around a set of scientific questions that I found challenging to answer in my own lab in academia. So we were very interested in my lab in thinking about all the different molecules and tick saliva that manipulate the skin barrier when a tick is feeding, but basically the, the ideal form of a team around this was, you know, like a very collaborative, highly skilled team that was, you know, strike team for like biochemical, fractionation, math spec, developing itch assays to get this done. It was [00:04:35] not a PhD style project of like one person sort of open-endedly exploring a question. So I was struggling to figure out how to get funding for this, but that wasn't even the right question because even with the right money, like it's still very challenging to set up the right team for this in academia. And so it was during this frustration that I started exploring with Kira about like, what is even the right way to solve this problem, because it's not gonna be through writing more grants. There's a much bigger problem here. Right? And so we started actually talking to people outside of academia. Like here's what we're trying to achieve. And actually the outcome we're really excited about is whether it could yield information that could be acted on for an actually commercializable product, right. There's like skin diseases galore that this could potentially be helpful for. So I think that transition was really important because it went from sort of like a passive idea to, oh, wait, how do we act as agents to figure out how to set this up correctly? [00:05:35] We started talking to angel investors, VCs people in industry. And that's how we learned that, you know, like itch is a huge area. That's an unmet need. And we had tools at our disposal to potentially explore that. So that's how tr started. And that I think was. The beginning of the end or the, the start of the beginning. However you wanna think about it. Because what it did, was it the process of starting trove? It was so fun and it was not at all in conflict with the way I was thinking about my science, the science that was happening on the team was extremely rigorous. And I experienced like a different structure. And that was like the light bulb in my head that not all science should be structured the same way. It really depends on what you're trying to achieve. And then I went down this rabbit hole of trying to study the history of what you might call meta science. Like what are the different structures and iterations of this that have happened over, over the history of even the United States. And it's, hasn't always been the same. Right? And then I think [00:06:35] like, as a scientist, like once you grapple with that, that the way things are now is not how they always have been. Suddenly you have an experiment in front of you. And so that is how Arcadia became born, because I realize. Couched within this trove experiment is so many things that I've been frustrated about that I, I, I don't feel like I've been maximized as the type of scientist that I am. And I really want to think in my career now about not how I fit into the current infrastructure, but like what other infrastructures are available to us. Right? [00:07:08] Ben: Nice. [00:07:09] Seemay: Yeah. So that, that was the beginning. [00:07:11] Ben: and, and so you, you then, I, I, I'm just gonna extrapolate one more, more step. And so you sort of like looked at the, the real, the type of work that you really wanted to do and determined that, that the, the structure of Arcadia that you've built is, is like perhaps the right way to go about enabling that. [00:07:30] Seemay: Okay. So a couple things I, I don't even know yet if Arcadia is the right way to do it. So I [00:07:35] feel like it's important for me to start this conversation there that I actually don't know. But also, yeah, it's a hypothesis and I would also say that, like, that is a beautiful summary, but it's still, it was still a little clunkier than the way you described it and the way I described it. So there's this gap there then of like, okay, what is the optimal place for me to do my science? How do we experiment with this? And I was still acting in a pretty passive way. You know, I was around people in the bay area thinking about like new orgs. And I had heard about this from like ju and Patrick Collison and others, like people very interested in funding and experimenting with new structures. So I thought, oh, if I could find someone else to create an organization. That I could maybe like help advise them on and be a part of, and, and so I started writing up this proposal that I was trying to actually pitch to other people like, oh, would you be interested in leading something like this? [00:08:35] Like, and the more that went on and I, I had like lots and lots and lots of conversations with other scientists in academia, trying to find who would lead this, that it took probably about six months for me to realize like, oh, in the process of doing this, I'm actually leading this. I think and like trying to find someone to hand the keys over to when actually, like, I seem to be the most invested so far. And so I wrote up this whole proposal trying to find someone to lead it and. It came down to that like, oh, I've already done this legwork. Like maybe I should consider myself leading it. And I've, I've definitely asked myself a bunch of times, like, was that like some weird internalized sexism on my part? Cause I was like looking for like someone, some other dude or something to like actually be in charge here. So that's actually how it started. And, and I think a couple people started suggesting to this to me, like if you feel so strongly about this, why aren't you doing this? And I know [00:09:35] it's always an important question for a founder to ask themselves. [00:09:38] Ben: Yeah, yeah, no, that's, that's really clutch. I appreciate you sort of going into the, the, the, the, the, the, like, not straight paths of it. Because, because I guess when we, we put these things into stories, we always like to, to make it like nice and, and linear and like, okay, then this happened and this happened, and here we are. But in reality, it was it's, it's always that ambiguity. Can, can I actually ask two, two questions based on, on that story? One is you, you mentioned that. In academia, even if you had the money, you wouldn't be able to put together that strike team that you thought was necessary. Like why can, can you, can you unpack that a little bit? [00:10:22] Seemay: Yeah. I mean, I think there's a lot of reasons why one of the important reasons, which is absolutely not a criticism of academia, in fact, it's maybe like my support of the [00:10:35] mission in academia is around training and education. That like part of our job as PIs and the research projects we set up is to provide an opportunity for a scientist to learn how to ask questions. How to answer those, how to go through the whole scientific process. And that requires a level of sort of like openness and willingness to allow the person to take the reigns on that. That I think is very difficult if you're trying to hit like very concrete, aggressive milestones with a team of people, right. Another challenge of that is, you know, the way we set up incentive structures around, you know, publishing, like we also don't set up the way we, you know, publish articles in journals to be like very collaborative or as collaborative as you would want in this scenario. Right. At the end of the day, there's a first author, there's the last author. And that is just a reality. We all struggle with despite everyone's best intentions. And so that inherently now sets up yeah. [00:11:35] Another situation where you're trying to figure out how you, we, this collaborative effort with this reality and. Even in the best case scenario, it doesn't always feel great. Right? Like it just like makes it harder to do the thing. And then finally, like it just, you know, for the way we fund projects in, in academia, you know, this wasn't a very hypothesis driven project. Like it's very hard to lay out specific aims for it. Beyond just the things we're gonna be trying to like, what, what, what is our process that we can lay [00:12:08] Ben: Yeah, it's a [00:12:09] Seemay: I can't tell you yeah. What the outcomes are gonna be. So I did write grants on that and that was repeatedly the feedback. And then finally, there's, you know, this other thing, which is that, like, we didn't want to accidentally land on an opportunity for invi innovation. We explicitly wanted to find molecules that could be, you know, engineered for products. Like that was [00:12:35] our hypothesis. If there is any that like. By borrowing the innovation from ticks who have evolved to feed for days to sometimes over a week that we are skipping steps to figure out the right natural product for manipulating processes in the skin that have been so challenging to, you know, solve. So we didn't want it to be an accident. We wanted to be explicitly translational quote unquote. So that again, poses another challenge within an academic lab where you, you have a different responsibility, right? [00:13:05] Ben: Yeah. And, and you it's there there's like that tension there between setting out to do that and then setting out to do something that is publishable, right? [00:13:14] Seemay: Mm-hmm mm-hmm . Yeah. Yeah. And I think one of the, the hard things that I'm always trying to think about is like, what are things that have out of the things that I just listed? What are things that are appropriately different about academia and what are the things that maybe are worth a second? [00:13:31] Ben: mm. [00:13:32] Seemay: they might actually be holding us back even [00:13:35] within academia. So the first thing I would say is non-negotiable that there's a training responsibility. So that is has to be true, but that's not necessarily mutually exclusive with also having the opportunity for this other kind of team. For example, we don't really have great ways in academia to properly, you know, support staff scientists at a, at a high level. Like there's a very limited opportunity for that. And I, you know, I'm not arguing with people about like the millions of reasons why that might be. That's just a fact, you know, so that's not my problem to solve. I just, I just see that as like a challenge also like of course publishing, right? Like I think [00:14:13] Ben: yeah, [00:14:14] Seemay: in a best case scenario publishing should be science should be in the driver's seat and publishing should be supporting those activities. I think we do see, you know, and I know there's a spectrum of opinions on this, but there are definitely more and more cases now where publishing seems to be in the [00:14:35] driver's seat, [00:14:36] Ben: yeah, [00:14:36] Seemay: dictating how the science goes on many levels. And, you know, I can only speak for myself that I, I felt that to be increasingly true as I advanced my career. [00:14:47] Ben: yeah. And just, just to, to make it, make it really explicit that it's like the, the publishing is driving because that's how you like, make your tenure case. That's how you make any sort of credibility. Everybody's gonna be judging you based on what you're publishing as opposed to any other. [00:15:08] Seemay: right. And more, I think the reason it felt increasingly heavy as I advanced my career was not even for those reasons, to be honest, it was because of my trainees, [00:15:19] Ben: Hmm. [00:15:20] Seemay: if I wanna be out. Doing my crazy thing. I have a huge responsibility now to my students, and that is something I'm not willing to like take a risk on. And so now my hands are tied in this like other way, and their [00:15:35] careers are important to me. And if they wanna go into academia, I have to safeguard that. [00:15:40] Ben: Yeah. I mean, it suggests. Sort of a, a distinction between sort of, regardless of academia or not academia between like training labs and maybe focused labs. And, and you could say like, yes, you, you want trainees in focus. Like you want trainees to be exposed to focused research. But like at least sort of like thinking about those differences seems really important. [00:16:11] Seemay: Yes. Yeah. And in fact, like, you know, because I don't like to, I don't like to spend too much time, like. Criticizing people in academia, like we even grapple with this internally at Arcadia, [00:16:25] Ben: Yeah. [00:16:25] Seemay: like there is a fundamentally different phase of a project that we're talking about sort of like new, creating new ideas, [00:16:35] exploring de-risking and then some transition that happens where it is a sort of strike team effort of like, how do you expand on this? How do you make sure it's executed well? And there's probably many more buckets than the, just the two I said, but it it's worthy of like a little more thought around the way we set up like approvals and budgets and management, because they're too fundamentally different things, you know? [00:17:01] Ben: Yeah, that's actually something I, I wanted to ask about more explicitly. And this is a great segue is, is sort of like where, where do ideas come from at Arcadia? Like how, you know, it's like, there's, there's some spectrum where everybody's from, like everybody's working on, you know, their own thing to like you dictating everything. Everything in between. So like, yeah. Can you, can you go more into like, sort of how that, that flow works almost? [00:17:29] Seemay: So I might even reframe the question a little bit to [00:17:35] not where do ideas come from, but how do ideas evolve? Because it's [00:17:39] Ben: please. Yeah. That's a much better reframing. [00:17:41] Seemay: because it's rarely the case, regardless of who the idea is coming from at Arcadia, that it ends where it starts. and I think that that like fluidity is I the magic sauce. Right. And so by and large, the ideas tend to come from the scientists themselves. Occasionally of course, like I will have a thought or Che will have a thought, but I see our roles as much more being there to like shepherd ideas in the most strategic and productive direction. And so we like, you know, I spent a lot of time thinking about like, well, what kind of resources would this take? And, you know, Che definitely thinks about that piece as well as, you know, like what it, what would actually be the impact of this if it worked in terms of like both our innovation, as well as the knowledge base outside of Arcadia Practically speaking, something we've started doing, that's been really helpful because we've gone. We've already gone through different iterations of this too. Like we [00:18:35] started out of like, oh, let's put out a Google survey. People can fill out where they pitch a project to us. And that like fell really flat because there's no conversation to be had there. And now they're basically writing a proposal. Yeah. More streamlined, but it's not that qualitatively different of a process. So then we started doing these things called sandboxes, which I'm actually really enjoying right now. These are every Friday we have like an hour long session. The entire company goes and someone's up at the dry erase board. We call it, throwing them in the sandbox and they present some idea or set of ideas or even something they're really struggling. For everybody to like, basically converse with them about it. And this has actually been a much more productive way for us to source ideas. And also for me to think collaboratively with them about like the right level of like resources, the right sort of inflection points for like, when we decide go or no, go on things. And so that's how we're currently doing it. I mean, we're [00:19:35] like just shy of about 30 people. I, this process will probably break again. once we hit like 50 people or something, cuz it's actually just like logistically a lot of people to cram into a room and there is a level of sort of like, yeah, and then there's a level of formality that starts to happen when there's like that many people in the room. So we'll see how it goes, but that's how it's currently working today. [00:20:00] Ben: that's that's really cool. And, and, and so then, then like, let's, let's keep following the, the evolutionary path, right. So an idea gets sandboxed and you collectively come to some conclusion that it's like, okay, like this idea is, is like, well worth pursuing then what happens. [00:20:16] Seemay: So then and actually we're like very much still under construction right now around this. We're trying to figure out like, how do, how do we think about budget and stuff for this type of step? But then presumably, okay, the person starts working on it. I can tell you where we're trying to go. I, I'm not sure where there yet, where we're trying to go is turning our [00:20:35] publications into a way to like actually integrate into this process. Like, ideally I would love it as CEO, if I can be updated on what people in the order are doing through our pub site. [00:20:49] Ben: Oh [00:20:50] Seemay: And that, like, I'm not saying they publish every single thing they do every day. Of course, that's crazy, crazy talk, but like that it's somewhat in line with what's happening in real time. That that is an appropriate place for me to catch up on what they're doing and think about like high level decisions and get feedback and see the feedback from the community as well, because that matters, right? Like if, if our goal is to either generate products in the form of actual products in the world that we commercialize versus knowledge products that are useful to others and can stimulate either more thought or be used by others directly. Like I need to actually see that data in the form of like the outside world interacting with their releases. Right. [00:21:35] So that's what we're trying to move towards, but there's a lot of challenges associated with that. Like if a, if a scientist is like needing to publish very frequently, How do we make sure we have the right resources in place to help them with that? There may be some aspects of that, that like anyone can help with like formatting or website issues or, you know, even like schematic illustrations to try and just like reduce the amount of friction around this process as much as possible. [00:22:00] Ben: And I guess almost just like my, my concern with the like publishing everything openly very early. And this is, this is almost where, where I disagree with with some people is that there's what, what I believe Sahi Baca called like the, the like Wardy baby problem, where ideas, when you're first sort of like poking at them are just like really ugly and you like, can't even, you can't even, like, you can barely justify it to [00:22:35] anybody on your team who like, trust you let alone people who like don't have any insight into the process. And so. Do do you, do you worry at all about like, almost just being like completely demoralized, right? Like it's just, it's so much easier to point out why something won't work early on than why it will. [00:22:56] Seemay: Yeah, totally. Yeah. [00:22:59] Ben: how do you [00:22:59] Seemay: Well, I mean, yeah, no, I think that's a hard, hard challenge. I mean, and, and people, and I would say at a metal level, I get, I get a lot of that too. Like people pointing out all the ways Arcadia [00:23:09] Ben: Yeah, I'm [00:23:10] Seemay: or potentially going to fail. So a couple things, I mean, I think one is that just, of course I'm not asking our scientists to. They have a random thought in the shower, like put that out into the world. right. Like there's of course some balance, like, you know, go through some amount of like thinking and like, you know, feedback with, with their most local peers on it. More, more in terms more than anything, like [00:23:35] just to like make sure by the time it goes out into the world that you're capturing precious bandwidth strategically. Right. [00:23:41] Ben: Yeah, [00:23:41] Seemay: On the other hand though, like, you know, while we don't want like that totally raw thing, we are so far on the, under the spectrum right now in terms of like forgiveness of some wards. And, and it also ignores the fact that like, it's the process, right? Like ugly baby. Great. That's that's like, like the uglier the better, like put it out there because like you want that feedback. You're not trying to be. trying to get to some ground truth here. And rigor happens through lots of like feedback throughout the entire process, especially at the beginning. And it's not even like that, that rigor doesn't happen in our current system. It's just that it doesn't make it out into the public space. People do share their thoughts with others. They do it at the dry erase board. They share proposals with each other. There's a lot of this happening. It's just not visible. So I mean, the other thing just like culturally, what I've been trying to like emphasize at [00:24:35] Arcadia is like process, not outcomes that like, you know, talking about it directly, as well as we have like an exercise in the beginning of thinking about like, what is the correct level of like failure rate quote unquote, and like what's productive failure. And just like, if we are actually doing like high risk, interesting science that's worth doing fundamentally, there's gotta be some inherent level of failure built in that we expect. Otherwise, we are answering questions. We already know the answer to, and then what's the fucking point. Right? [00:25:05] Ben: Yeah, [00:25:06] Seemay: So it almost doesn't matter what the answer to that question is. Like people said like 20%, some people said 80%, there's a very wide range in people's heads. Cuz there's this, isn't not a precise question. Right. So there's not gonna be precise answers, but the point is like the acceptance of that fact. Right? [00:25:24] Ben: Yeah. And also, I, I think I'm not sure if you would agree with this, but like, I, I feel like even like failure is a very fuzzy concept. In this, in this context, [00:25:35] right? [00:25:35] Seemay: totally. I actually really hate that word. We, we are trying to rebrand it internally to pivots. [00:25:42] Ben: Yeah. Yeah. I like that. I also, I also hate in this context, the idea of like risk, right? Like risk makes sense when it's like, you're getting like cash on cash returns, but [00:25:54] Seemay: right. [00:25:54] Ben: when [00:25:55] Seemay: Yeah. Yeah. I mean, you can redefine that word in this case to say like, it's extremely risky for you to go down this safe path because you will be very likely, you know, uncovering boring things. That's a risk, right? [00:26:13] Ben: Yeah. And then just in terms of process, I wanna go one, one step further into the, sort of like the, the like strike teams around an idea. Is it like something like where, where people just volunteer do do they get, like how, how, how do you actually like form those teams? [00:26:30] Seemay: Yeah. So far there has not been like sort of top down forcing of people into things. I [00:26:35] mean, we are a small org at this point, but like, I think like personally, my philosophy is that like, people do their best work when they're, they feel agency and like sort of their own deep, inner inspiration to do it. And so I try to make things more ground up because of that. Not, not just because of like some fuzzy feeling, but actually I think you'll get the best work from people, if you'd set it up that way. Having said that, you know, there are starting to be situations where we see an opportunity for a strike team project where we can, like, we need to hire someone to come. [00:27:11] Ben: Mm-hmm [00:27:12] Seemay: because no one existing has that skill set. So that that's a level of like flexibility that like not everybody has in other organizations, right. That you have an idea now you can hire more people onto it. So I mean, that's like obviously a huge privilege. We have to be able to do that where now we can just like transparently be like, here's the thing who wants to do it? You know? [00:27:32] Ben: yeah, yeah. [00:27:35] That's, that's very cool. [00:27:36] Seemay: One more thing else. Can I just say one more thing about that [00:27:39] Ben: of course you can see as many things as you [00:27:40] Seemay: yeah. Actually the fact that that's possible, I feel like really liberates people at Arcadia to think more creatively because something very different happens when I ask people in the room. What other directions do you think you could go in versus what other directions do you think this project should go, could go in that we could hire someone from the outside to come do. Because now they like, oh, it doesn't have to be me. Or maybe they're maybe it's because they don't have the skillset or maybe they're attached to something else that they're working on. So making sure that in their mind, it's not framed as like an either or, but in if, and, and that they can stay in their lane with what they most wanna do. If we decide to move forward on that, you know? Cause I, I think that's often something that like in academia, we don't get to think about things that way. [00:28:30] Ben: Yeah, absolutely. And then the, the people that you would hire onto a [00:28:35] project, would they, like, so say, say, say the, the project then ends it, it reaches some endpoint. Do they like then sort of go back into the, the pool of people who are, are sandboxing? How do, how does that [00:28:49] Seemay: So we, So we haven't had that challenge on a large scale yet. I would say from a human perspective, I would really like to avoid a situation where like standard biotech companies, you know, if an area gets closed out, there's a bunch of layoffs. Like it would be nice to figure out how we can like, sort of reshuffle everybody. One of the ways this has happened, but it's not a problem yet is like we have these positions called arcade scientists, which is kind of meant for this to allow people to kind of like move around. So there's actually a couple of scientists that Arcadia that are quote unquote arcade it's meant to be like a playful term for someone who's a, a generalist in some area like biochemistry, [00:29:35] generalist computational generalist, something like that, where their job is literally to just work on like the first few months of any project. [00:29:44] Ben: oh, [00:29:45] Seemay: And help kind of like, de-risk like, they're really tolerant of that process. They like it. They like trying to get something brand new off the ground. And then once it becomes like more mature with like clear milestones, then we can hire someone else and then they move on to like the next thing, I think this is a skill in itself that doesn't really get highlighted in other places. And I think it's a skillset that actually resonates with me very much personally, because if I were applying to Arcadia, that is the position that I would want. [00:30:14] Ben: I, I think I'm in the same boat. Yeah, that, and that's, that's critical is like, there aren't a lot of organizations where you sort of like get to like come in for a stage of a project. In research, like there, it it's generally like you're, you're on this project. [00:30:29] Seemay: And how often do you hear people complain about that in science of like, oh, so and so they're, they're [00:30:35] really great at starting things, but not finishing things. It's like, well, like how do we capitalize on that then? [00:30:39] Ben: yeah. Make it a feature and not a bug. Yeah, no, it's like, it it's sort of like having, I I'm imagining like sort of just different positions on a, a sports team, for example. And, and I feel like I, I was thinking the other day that that analogies between like research organizations and sports teams are, are sort of underrated right. Like you don't expect like the goal to be going and like, like scoring. Right. And you don't, you don't say like, oh, you're underperforming goalie. You didn't score any goals. [00:31:08] Seemay: Right. That's so funny. I like literally just had a call with Sam Aman before this, where, where we were talking about this a little bit, we were talking about in a slightly different context about a role that I feel like is important in our organization of someone to help connect the dots across the different projects. What we were sort of like conceptualizing in my call with him as like the cross pollinators, like the bees in the organization that like, know what get in the [00:31:35] mix, know what everyone's doing and help everybody connect the dots. And like, I feel like this is some sort of a supportive role. That's better understood on sports teams. Like there's always someone that's like the glue, right? Maybe they're not the MVP, but they're the, the other guy that's like, or, you know, girl, whatever, UN gendered, but very important. Everybody understands that. And like, it's like celebrated, you know, [00:31:58] Ben: Yeah. Yeah. And it's like, and, and the trick is, is really seeing it more like a team. Right. So that's like the, the overarching thing. [00:32:07] Seemay: And then I'll just like, I don't know, just to highlight again though, how like these realities that you and I are talking about that I think is actually very well accepted across scientists. We all understand these different roles. Those don't come out in the very hierarchical authorship, byline of publications, which is the main currency of the system. And so, yeah, that's been fascinating to like, sort of like relearn because when we started this publishing experiment, [00:32:35] I was primarily thinking about the main benefit being our ability to do different formats and in a very open way. But now I see that this there's this whole other thing that's probably had the most immediate impact on Arcadia science, which is the removal of the authorship byline. [00:32:52] Ben: Mm. So, so you don't, you don't say who wrote the thing at all. [00:32:57] Seemay: We do it's at the bottom of the article, first of all. And then it's listed in a more descriptive way of who did what, it's not this like line that's like hierarchical, whether implicitly or explicitly and for my conversations with the scientists at Arcadia, like that has been really like a, a wonderful release for them in terms of like, thinking about how do they contribute to projects and interact with each other, because it's like, it doesn't matter anymore that that currency is like off the table. [00:33:27] Ben: Yeah. That that's very cool. And can, can I, can I change tracks a little bit and ask you about model organisms? [00:33:34] Seemay: sure [00:33:34] Ben: [00:33:35] so like, and this is, this is coming really from my, my naivete, but like, like what, what are model organisms? And like, why is having more of them important? [00:33:47] Seemay: So there's, this is super, super important for me to clarify there's model organisms and there's non-model organisms, but there's actually two different ways of thinking about non-model organisms. Okay. So let me start with model organisms. A model organism is some organism that provides an extremely useful proxy for studying typically like either human biology or some conserved element of biology. So, you know, the fact that like we have. Very similar genetic makeup to mice or flies. Like there's some shortcuts you can take in these systems that allow you to like quickly ask experimental questions that would not be easy to do in a human being. Right. Like we obviously can't do those kinds of experiments there.[00:34:35] And so, and so, so the same is true for like ASIS, which can be a model for plants or for like biology more generally. And so these are really, really useful tools, especially if you think about historically how challenging it's been to set up new organisms, like, think about in the fifties before we could like sequence genomes as quickly or something, you know, like you really have to band together to like build some tools in a few systems that give you useful shortcuts in general, as proxies for biology now. [00:35:11] Ben: can I, can I, can I just double click right there? What does it mean to like set it up? Like, like what, what does it mean? Like to like, yeah. [00:35:18] Seemay: Yeah. I mean, there's basic anything from like Turing, right? Like you have to learn how to like cultivate the organism, grow it, proliferate it. Yeah. You gotta learn how to do like basic processing of it. Like whether it's like dissections or [00:35:35] isolating cell types or something, usually some form of genetics is very useful. So you can perturb the system in some controlled way and then ask precise questions. So those are kinda like the range of things that are typically challenging to set up and different organisms. Like, I, you can think of them as like video game characters, they have like different strengths, right? Like different bars. Some are [00:35:56] Ben: Yeah. [00:35:59] Seemay: fantastic for some other reason. You know, whether it's cultivation or maybe something related to their biology. And so that's that's model organisms and. I am very much pro model organisms. Like our interest in non-model organisms is in no way in conflict with my desire to see model organisms flourish, right. That fulfills an important purpose. And we need more, I would say, non-model organisms. Now. This is where it gets a little murky with the semantics. There's two ways you could think about it. At least one is that these are organisms that haven't quite risen to the level of this, the [00:36:35] canonical model organisms in terms of like tooling and sort of community effort around it. And so they're on their way to becoming model, but they're just kinda like hipster, you know, model or model organisms. Maybe you could think about it like that. There's a totally different way to think about it, which is actually how Arcadia's thinking about it, is to not use them as proxy for shared biology at all. But focus on the biology that is unique about that organism that signals some unique biological innovation that happened for that organism or plate of organisms or something. So for example, ticks releasing a bunch of like crap in their saliva, into your skin. That's not a proxy for us, like feeding on other, you know, vertebrates that is an innovation that happened because ticks have this like enormous job they've had to evolve to learn, to do well, which is to manipulate everything about your [00:37:35] circulation, your skin barrier, to make sure it's one blood meal at each of its life stages happen successfully and can happen for days to over a week. It's extremely prolonged. It can't be detected. So that is a very cool facet about tech biology that we could now leverage to learn something different. That could be useful for human biology, but that's, it's not a proxy, right? [00:37:58] Ben: Yeah. And so, so I was gonna ask you why ticks are cool, but I think that that's sort of self explanatory. [00:38:05] Seemay: Oh, they're wild. Like they, like, they have this like one job to do, which is to drink your blood and not get found out. [00:38:15] Ben: and, and I guess like, is there, so, so like with ticks, I I'm trying to, to frame this, like, is there something useful in like comparing like ticks and mosquitoes? Do they like work by the same mechanisms? Are they like completely different [00:38:30] Seemay: yeah. There's no, there's definitely something interesting here to explore because blood [00:38:35] feeding as a behavior in some ways is a very risky behavior. Right. Any sort of parasitism like that. And actually blood [00:38:42] Ben: That's trying to drink my blood. [00:38:44] Seemay: Yes. That's the appropriate response. Blood feeding actually emerged multiple times over the course of evolution in different lineages and mosquitoes, leeches ticks are in very different clouds of organisms and they have like different strategies for solving the same problem that they've evolved independently. So there's some convergence there, but there's a lot of divergence there as well. So for example, mosquitoes, and if you think about mosquitoes, leaches, and tick, this is a great spectrum because what's critically different about them is the duration of the blood [00:39:18] Ben: Mm, [00:39:19] Seemay: feed for a few seconds. If they're lucky, maybe in the range of minutes, leaches are like minutes to hours. Ticks are dazed to over a week. Okay. So like temporally, like they have to deal with very different. For, for mosquitoes, they tend to focus on [00:39:35] like immediately numbing of the local area to getting it out. Right. Undetected, Lees. They they're there for a little bit longer, so they have very cool molecules around blood flow like that there's a dilation, like speeding up the amount of blood that they can intake during that period. And then ticks have to deal with not just the like immediate response, but also longer term response, inflammation, wound healing, all these other sensations that happen. If, imagine if you stuck a needle in yourself for a week, like a lot more is going on, right? [00:40:08] Ben: Yeah. Okay. That, that makes a lot of sense. And so, so they really are sort of unique in that temporal sense, which is actually important. [00:40:17] Seemay: Yeah. And whether it's positive or not, it does seem to track that duration of that blood meal at least correlates with sort of the molecular complexity in terms of Sliva composition from each of these different sets of organisms. I just list. So there's way more proteins in other molecules that [00:40:35] have been detected int saliva as opposed to mosquito saliva. [00:40:39] Ben: And, and so what you're sort of like one of your, your high level things is, is like figuring out which of those are important, what mixture of them are important and like how to replicate that for youthful purposes? [00:40:51] Seemay: Yeah. Right, exactly. Yeah. [00:40:54] Ben: and, and, and are there other, like, I mean, I, I guess we can imagine like farther into Arcadia's future and, and think about like, what do you have, like, almost like a, like a wishlist or roadmap of like, what other really weird organisms you want to start poking at? [00:41:13] Seemay: So actually, so that, that is originally how we were thinking about this problem for non-model organisms like which organisms, which opportunities and that itself has evolved in the last year. Well, we realized in part, because of our, just like total paralysis around this decision, because [00:41:35] what we didn't wanna do is say, okay, now Arcadia's basically decided to double down on these other five organisms. We've increased the Canon by five now. Great. Okay. But actually that's not what we're trying to do. Right. We're trying to highlight the like totally different way. You could think about capitalizing on interesting biology and our impact will be felt more strongly if it happens, not just in Arcadia, but beyond Arcadia for this to be a more common way. And, and I think like Symbio is really pushing for this as a field in general. So we've gone from sort of like which organisms to thinking about. Maybe one of our most important contributions is to ask the question, how do you decide which organism, like, what is even the right set of experiments to help you understand that? What is the right set of data? That you might wanna collect, that would help you decide, let's say for example, cuz this is an actual example. We're very interested in produce diatoms, algae, other things, which, [00:42:35] which species should you settle on? I don't know. Like there's so many, right? Like, so then we started collecting like as many we could get our hands on through publicly available databases or culture collections. And now we are asking the meta question of like, okay, we have these, what experiments should we be doing in a high throughput way across all of these to help us decide. And that itself, that process, that engine is something that I think could be really useful for us to share with the worlds that is like hard for an individual academic lab to think about. That is not aligned with realities of like grants and journal publications and stuff. And so, yeah. Is it like RNA seek data sets? What kind of like pheno assays might you want, you want to collect? And we now call this broadly organismal onboarding process. Like what do you need in the profile of the different organisms and like, is it, phenomics now there's structural [00:43:35] prediction pipelines that we could be running across these different genomes depending on your question, it also may be a different set of things, but wouldn't it be nice to sort of just slightly turn the ES serendipity around, like, you know, what was around you versus like, can we go in and actually systematically ask this question and get a little closer to something that is useful? You know, [00:43:59] Ben: Yeah. [00:43:59] Seemay: and I think the amazing thing about this is. You know, I, and I don't wanna ignore the fact that there's been like tons of work on this front from like the field of like integrative biology and evolutionary biologists. Like there's so much cool stuff that they have found. What I wanna do is like couple their thinking in their efforts with like the latest and greatest technologies to amplify it and just like broaden the reach of the way they ask those questions. And the thing that's awesome about biology is even if you didn't do any of this and you grabbed like a random butterfly, you would still find extremely cool stuff. So that's the [00:44:34] Ben: [00:44:35] Right. Yeah. [00:44:36] Seemay: like, where can we go from here now that we have all these different technologies at our disposal? [00:44:41] Ben: Yeah. No, that's, that's extremely cool. And I wanted to ask a few questions about Arcadia's business model. And so sort of like it's, it's a public fact, unlike a lot of research organizations, Arcadia is, is a for-profit organization now, of course, that's that's a, you and I know that that's a legal designation. And there's like, I, I almost think of there as being like some multidimensional space where it's like, on the one hand you have like, like the Chan Zuckerberg initiative, which is like, is nominally a for-profit right. In the sense of [00:45:12] Seemay: Yeah. [00:45:13] Ben: not a, it's not a non-profit organization. And then on the other hand, under the spectrum, you have maybe like something like a hedge fund where it's like, what is like the only purpose of this organization in the world is to turn money into more money. Right. And so like, I, I guess I'd love to know like how you, how you think about sort of like where in that domain you [00:45:34] Seemay: [00:45:35] Yeah. Yeah. So, okay. This [00:45:38] Ben: and like how you sort of came to that, that [00:45:41] Seemay: Yeah. This was not a straightforward decision because actually I originally conceived of the Arcadia as a, a non-profit entity. And I think there were a lot of assumptions and also some ignorance on my part going into that. So, okay. Lemme try and think about the succinct way to tell all this. So I [00:45:58] Ben: take, take, take your time. [00:46:00] Seemay: okay. I started talking to a lot of other people at organizations. Like new science type of organizations. And I'll sort of like refrain from naming names here out of respect for people. But like they ran into a lot of issues around being a nonprofit, you know, for one, it, it impacted sort of like just sort of like operational aspects, maintaining a nonprofit, which if, if you haven't done it before, and I learned like, by reading about all this and learning about all this, like it maintaining that status is in and [00:46:35] of itself and effort, it requires legal counsel. It requires boards, it requires oversight. It requires reporting. There's like a whole level of operations [00:46:45] Ben: Yeah. And you always sort of have the government looking over your shoulder, being [00:46:49] Seemay: Yep. And you have to go into it prepared for that. So it also introduces some friction around like how quickly you can iterate as an organization on different things. The other thing is that like Let's say we started as a nonprofit and we realized, oh, there's a bunch of like for-profit type activities. We wanna be doing the transition of converting a nonprofit to a for-profit is actually much harder than the other way around. [00:47:16] Ben: Mm. [00:47:17] Seemay: And so that sort of like reversibility was also important to me given that, like, I didn't know exactly what Arcadia would ultimately look like, and I still dunno [00:47:27] Ben: Yeah. So it's just more optionality. [00:47:29] Seemay: Yeah. And another point is that like I do have explicit for profit interests for [00:47:35] Arcadia. This is not like, oh, I like maybe no. Like we like really want to commercialize some of our products one day. And it's, it's not because we're trying to optimize revenue it's because it's very central to our financial experiment that we're trying to think about, like new structures. Basic scientists and basic science can be, can capture its own value in society a little bit more efficiently. And so if we believe the hypothesis that discovering new biology across a wide range of organisms could yield actionable lessons that could then be translated into real products. Then we have to make a play for figuring out how this, how to make all this work. And I like also see an opportunity to figure out how I can make it work, such that if we do have revenue, I make sure our basic scientists get to participate in that. You know, because that is like a huge frustration for me as a basic scientist that like we haven't solved this problem. [00:48:35] Like basic science. It's a bedrock for all downstream science. Yet we some have to have, yeah, we have to be like siloed away from it. Like we don't get to play a part in it. And also the scientists at our Katy, I would say are not like traditional academic scientists. Like I would, I, my estimate would be like, at least a third of them have an intentional explicit interest in being part of a company one day that they helped found or spin out. And so that's great. We have a lot of like very entrepreneurial scientists at Arcadia. And so I I'm, I'm not shying away from the fact that like, we are interested in a, for profit mission. Having said all of that, I think it's important to remember that like mission and values don't stem from tax structure, right? Like you, there are nonprofit organizations that have like rotten values. And there are also for-profit organizations that have rotten values, like that is not the [00:49:35] dividing line for this. And so I think it puts the onus on us at Arcadia though, to continuously be rigorous with ourselves accountable to ourselves, to like define our values and mission. But I don't think that they are like necessarily reliant on the tax structure, especially in a for-profit organization where there's only two people at the cap table and their original motivating reason to do doing this was to conduct a meta science experiment. So we have like a unique alignment with our funders on this that I think also makes us different from other for-profit orgs. We're not a C Corp, we're an LC. And actually we're going through the process right now of exploring like B Corp status, which means that you have a, a fundamental, like mix of mission and for profit. [00:50:21] Ben: Yeah. That was actually something that I was going to ask about just in, in terms of, I think, what sort of like implicitly. One of the reasons that people wonder about [00:50:35] the, the mixture of like research and for profit status is that like the, the, the time scales of research is just, are just long, right? Like, like re, re research research takes a long time and is expensive. And if, if you're like, sort of answering to investors who are like really like, primarily looking for a return on their investment I feel like that, I, I mean, at least just in, in my experience and like my, my thinking about this like that, that, that's, that's my worry about it is, is that like so, so what, like having like, really like a small number of really aligned investors seems like pretty critical to being able to like, stick to your values. [00:51:18] Seemay: Yeah, no, it's true. I mean, there were actually other people interested in funding, our Arcadian every once in a while I get reached out to still, but like me Jud and Sam and Che, like we went through the ringer together. Like we went on this journey together to get here, to [00:51:35] decide on this. And I think there is, I think built in an understanding that like, there's a chance this will fail financially and otherwise. Um, but, but I think the important case to consider is like that we discussed is like, what would happen if we are a scientific success, but a financial failure. What are each of you interested in doing. and that that's such an important answer. A question, right? So for both of them, the answer was we would consider the option of endowing this into a nonprofit, but only if the science is interesting. Okay. If that is, and I'm not saying that we're gonna target that end goal, like I'm gonna fight with all my might to figure out another way, but that is a super informative answer, right? Because [00:52:27] Ben: yeah, [00:52:27] Seemay: delineating what the priorities are. The priority is the science, the revenue is [00:52:35] subservient to that. And if it doesn't work fine, we will still iterate on that like top priority. [00:52:42] Ben: Yeah, it would also be, I mean, like that would be cool. It would also be cool if, if you, I mean, it's just like, everybody thinks about like growing forever, but I think it would be incredibly cool if you all just managed to make enough revenue that you can just like, keep the cycle going right. [00:52:58] Seemay: Yeah. It also opens us up to a whole new pocket of investments that is difficult in like more standard sort of like LP funded situations. So, you know, given that our goal is sustainability now, like things that are like two to five X ROI are totally on the table. [00:53:22] Ben: Yeah. Yeah, yeah. [00:53:24] Seemay: actually that opens up a huge competitive edge for us in an area of like tools or products that like are not really that interesting to [00:53:35] LPs that are looking to achieve something else. [00:53:38] Ben: yeah, with like a normal startup. And I think that I, I, that that's, I think really important. Like I, I think that is a big deal because there's, there's so many things that I see And, and it's like the two to five X on the amount of money that you could capture. Right. But like the, the, the amount of value that you create could be much, much larger than that. Right. Like, and this is the whole problem. Like, I, I, I mean, it's just like the, the thing that I always run into is you look at just like the ability of people to capture the value of research. And it just is very hard to, to like capture the whole thing. And often when people try to do that, it ends up sort of like constraining it. And so you're, you're just like, okay, with getting a reasonable return then it just lets you do so many other cool things. [00:54:27] Seemay: yeah. I'm yeah. I think that's the vibe. [00:54:32] Ben: that is an excellent vibe. And, and speaking [00:54:35] with the vibe and, and you mentioned this I'm, I. Interested in both, like how you like find, and then convince people to, to join Arcadia. Right. Because it's, it's like, you are, you are to some extent asking people to like play a completely different game. Right? Like you're asking people who have been in this, this like you know, like citations and, and paper game to say like, okay, you're gonna like, stop playing that and play this other thing. And so like, yeah. [00:55:04] Seemay: yeah. It's funny. Like I get asked this all the time, like, how do you protect the careers or whatever of people that come to Arcadia? And the solution is actually pretty simple, even though people don't think of it, which is you Don. You don't try and convince people to come. Like we are not trying to grow into an infinitely large organization. I don't even know if we'll ever reach that number 150. Like I was just talking to Sam about like, we may break before that point. Like, that's just sort of like my cap. We may find that [00:55:35] 50 people is like the perfect number 75 is. And you know, we're actually just trying to figure out like, what is, what are the right ingredients for the thing we're trying to do? And so therefore we don't need everybody to join. We need the right people to join and we can't absorb the risk of people who ultimately see a career path that is not well supported by Arcadia. If we absorb that, it will pull us back to the means. because we don't want anyone at Arcadia to be miserable. We want scientists to succeed. So actually the easiest way to do that is to not try and convince people to do something they're not comfortable with and find the people for whom it feels like a natural fit. So actually think, I think I saw on Twitter, someone ask this question in your thread about what's like the, oh, an important question you asked during your interviews. And like one of the most important questions I ask someone is where else have you applied for jobs? [00:56:35] And if they literally haven't applied anywhere outside of academia, like that's an opportunity for me to push [00:56:43] Ben: Mm. [00:56:44] Seemay: I'm very worried about that. Like, I, I don't want them to be quote unquote, making a sacrifice that doesn't resonate with where they're trying to go in their career. Cuz I can't help them AF like once they come. Arcadia has to evolve like its own organism. And like, sometimes that means things that are not great for people who wanna be in academia, including like the publishing and journal bit. And so yeah, what I tell them is like, look, you have two jobs at Arcadia and both have to be equally exciting to you. And you have to fully understand that there both your responsibility, your job is to be a scientist and a meta scientist. And that those two things have to be. You understand what that second thing is that your job is to evolve with me, provide me with feedback on like, what is working and not working [00:57:35] for you and actively participate in all the meta science experiments that we're doing around publishing translation, technology, all these things, right? Like it can't be passive. It has to be active. If that sounds exciting to you, this is a great place for you. If you're trying to figure out how you're going to do that, have your cake and eat it too, and still have a CV that's competitive for academia in case like in a year, you know, like you go back, I, this is not the place for you. And I, I can't as a human being, like, that's, I, I can't absorb that because like, I like, I can't help, but have some empathy for you once you're here as an individual, like, I don't want you to suffer. Right. And so we need to have those hard conversations early before they join. And there's been a few times where like, yeah, I think like I sufficiently scared someone away. So I think it was better for them. Right? Like it's better for [00:58:25] Ben: Yeah, totally. [00:58:25] Seemay: if that happens. Yeah, it's harder once they're here. [00:58:29] Ben: and, and so, so the like, The, they tend to be people who are sort of like already [00:58:35] thinking, like already have like one foot out the door of, of academia in the sense of like, they're, they're already sort of like exploring that possibility. So they've so you don't have to like get them to that point. [00:58:48] Seemay: Right. Yes. Because like, like that's a whole journey they need to go on in, on their own, because there's so many reasons why someone might be excited to leave academia and go to another organization like this. I mean, there's push and pull. Right. So I think that's a challenge, like separating out, like, like what is just like push, because they're like upset with how things are going there versus like, do they actually understand what joining us will entail? And are they, do they have the like optimism and the agency to like, help me do this experiment. It does require optimism. Right. [00:59:25] Ben: absolutely. [00:59:25] Seemay: So like sometimes like, you know, I push people, like what, where else have you applied for jobs? And they, if they can't seem to answer that very well I say, okay, let me change [00:59:35] this question. You come to Arcadia and I die. Arcadia dissolves. It's, it's an easier way of like, it's like, I can own it. Okay. Like I died and like me and Che and Jed die. Okay. Like now what are you gonna do with your career? And like, I is a silly question, but it's kind of a serious question. Like, you know, just like, what is, how does this fit into your context of how you think about your career and is it actually going to move you towards where you're trying to go? Because, I mean, I think like that's yeah. Another problem we're trying to solve is like scientists need to feel more agency and they won't feel agency by just jumping to another thing that they think is going to solve problems for them. [01:00:15] Ben: Yeah, that's a really good point. And so, so this is almost a selfish question, but like where do you find these people? Right? Like you seem to, you seem to be very good at it. [01:00:26] Seemay: Yeah. I actually don't I don't, I, I don't know the answer to that question fully because we [01:00:35] only just recently said, oh my God, we need to start collecting some data through like voluntary surveys from applicants of like, how do they know about us? You know? It seems to be a lot of like word of mouth, social media, maybe they read something that I wrote or that Che wrote or something. And while that's been fine so far, we also like wanna think about how we like broaden that reach further. It's definitely not through their, for the most part, not through their institutes or PIs that I know. [01:01:03] Ben: Yeah, I, but, but it is, it is like, it sounds like it does tend to be inbounds, right? Like it tends to be people like reaching out to you as opposed to the other way around. [01:01:16] Seemay: Yeah. You know, and that's not for lack of effort. I mean, there have been definitely times where. We have like proactively gone out and tried to scout people, but it does run into that problem that I just described before of like, [01:01:29] Ben: Yeah. [01:01:30] Seemay: if you find them yourself, are you trying to pull them in and have they gone through their own [01:01:35] journey yet? And so in some of those cases, while it seemed like, like we entertain like conversations for a while with a couple of candidates, we tried to scout, but ultimately that's where it ended was like, oh, they like, they need to go on their own. And like, sort of like fully explore for a bit, you know, this would be a bit risky. But it hasn't, you know, it hasn't been all, you know a failure like that, but it, it happens a lot. [01:01:58] Ben: Yeah, no, I mean that, that, frankly, that, that squares with my, my experience sort of like roughly, roughly trying to find people who, who fit a similar mold. So that that's, I mean, and that, that suggests a strategy, right. Is like, be like, be good at setting up some kind of lighthouse, which you, you seem to have done. [01:02:17] Seemay: The only challenge with this, I would say, and, and we are still grappling with this is that sort of approach does make it hard to reach candidates that are sort of like historically underrepresented, because they may not see themselves as like strong candidates for such and such. And [01:02:35] so now we're, now we have this other challenge to solve of like, how do we make sure people have gone through their own process on their own, but also make sure that the opportunity is getting communicated to the right people and that they like all, everybody understands that they're a candidate, you know, [01:02:53] Ben: Yeah. And I guess so , as long as we're recording this podcast, like what, what is that like, like if you were talking to someone who was like, what does that process even look like? Like what would I start doing? Like what would you, what would you tell someone? [01:03:08] Seemay: Oh, to like explore a role at Arcadia. [01:03:11] Ben: yeah. Or just like to like, go through that, like, like to, to start going through that [01:03:16] Seemay: Yeah. Yeah, I mean, I guess like, there's probably a couple of different things. Like, I mean, one is just some deep introspection on like, what are your priorities in your life, right? Like what are you trying to achieve in your career? Beyond just like the sort of ladder thing, like what's the, what are the most important, like north stars for you? And I think [01:03:35] like for a place like Arcadia or any of the other sort of like meta science experiments, That has to be part of it somehow. Right. Like being really interested and passionate about being part of finding a solution and being one of the risk takers for them. I think the other thing is like very pragmatic, just like literally go out there and like explore other jobs, please. Like, I feel like, you know, like, like what is your market value? You know? Like what [01:04:05] Ben: don't don't [01:04:05] Seemay: Yeah. Like, and like go get that information for yourself. And then you will also feel a sense of like security, because like, even if I die and Arcadia dissolves, you will realize through that process that you have a lot of other opportunities and your skillset is highly valuable. And so there is like solid ground underneath you, regardless of what happens here, that they need to absorb that. Right. And then also just. Like, trust me, your negotiations with me will go way better. If you come in [01:04:35] armed with information, like one of my goals with like compensation for example, is to be really accurate about making sure we're hitting the right market val
Krijn Soeteman was vier keer eerder te horen in onze podcast, is wetenschapsjournalist en schreef het boek Cryptovaluta voor Dummies. Zijn nieuwe boek heet de Crypto Encyclopedie en is een naslagwerk voor iedereen die vragen heeft over Bitcoins en blockchains. We praten in deze extra gezellige aflevering over waarom games zo duur zijn en Randal's liefde voor Elden Ring en het karakter ‘Let Me Solo Her'.ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt, afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT.Tijdschema00:00:00 Reclame: ICT Group00:00:33 Weer corona?!00:03:09 Voorstellen: Krijn Soeteman00:04:34 Waarom een Crypto Encyclopedie00:18:39 Een ode aan Reply-All00:24:37 Waarom Diablo Immortal zo duur is00:38:27 Jezelf onderdompelen in Elden Ring00:50:02 Reclame: Calco00:51:42 Vragen van de luisteraars01:22:15 Tips01:30:57 AfkondigingTipsRandal PeelenDuw het laatste beetje plas wegRick Astley - Song Exploder over Never Gonna Give You UpFloris BotBuurman & BuurmanJurian UbachsTekengeld podcast door Yordi YamaliKrijn SoetemanAtlas podcastAnders - gender door de ogen van een primatoloog van Frans de WaalZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Davy van Iersel is directeur van Fujitsu Nederland. Hij lijkt in de wieg te zijn gelegd als manager en vond al snel zijn weg naar de IT langs werkgevers zoals SAP, CGI en Capgemini. Zijn nieuwe uitdaging is het lokaal aansturen van een gigantisch internationaal technologiebedrijf dat de oorsprong kent in Japan.We spreken Davy over de uitdagingen van een bedrijf dat bijna alles bouwt waar een stekker aan zit, en ook diensten levert zonder stekker. Wat zijn zijn grootste uitdagingen en hoe verenigt hij de Japanse cultuur met zijn oerhollandse werknemers?Davy noemt duurzaamheid als belangrijk doel en betoogt dat technische innovatie een belangrijke manier is om dat te bereiken. Bijvoorbeeld door leverketens beter en betrouwbaarder in kaart te brengen.Je leest het: meer een corporate C-level stropdas dan een die-hard nerd, maar wel een die met schaamteloos enthousiasme dagelijks naar zijn werk fietst.ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt, afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT.Tijdschema00:00:01 Reclame: ICT Group00:00:34 Vreugde en trots00:02:46 Voorstellen: Davy van Iersel00:05:27 Een nerd in colbert?00:08:35 Jarenlang sales via de webcam00:15:33 Wat doet Fujitsu allemaal?00:25:57 Data inzichtelijk maken00:29:11 De grote concurrenten van Fujitsu00:34:21 Kleding volgen met een blockchain00:46:54 Hoe Nederlanders omgaan met Japanse cultuur01:06:50 Reclame: Calco01:09:21 Vragen van de luisteraars01:36:05 Tips01:50:40 AfkondigingTipsFloris BotCreate kanaal op YoutubeRandal PeelenDigital Nomad Set van BellroyElectric Callboy Beginner vs Pro van Parker WalbeckDavy van IerselScoritoPloegleiderZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Alex Schoonkind is een veteraan in de betalingsindustrie en ziet een gat in de markt waar hij met zijn startup Fung middenin springt. Geïnspireerd door Pieter Thiel durft hij het aan een markt proberen wakker te schudden die al goed en wel verzadigd lijkt. Want waar de relatief ouderwetse betalingproviders moeite hebben nieuwe en veelzijdige manieren van betalen te implementeren bouwt Fung een ‘single checkout voor crypto & fiat'.Als kers op de taart leven wij mee met Anna-Eva en leggen we uit hoe je de beste schoenen ooit kunt kopen op StockX.ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt, afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT.Tijdschema00:00:00 Een nieuw uitzicht00:05:42 Voorstellen: Alex Schoonkind00:06:30 De sportieve kant van paaldansen00:08:31 Hoe werkt de betaalindustrie?00:19:05 Clearing and settling00:31:40 De invloed van PSD200:41:52 Valuta converteren tijdens het betalen00:52:44 Programmeerbaar geld waarmee de overheid bepaalt wat jij koopt01:06:22 Reclame: Calco01:08:45 Sneakers verzamelen01:18:12 Vragen van de luisteraars01:32:37 Tips01:57:58 AfkondigingTipsAlex Schoonkindweb3 with a16z podcastIntroducing the 2022 State of Crypto ReportRandal PeelenLightswing39x Tips for Better Sleep! van Mark Vletter op Youtube‘The end of the everything bubble' op The Ezra Klein ShowJurian UbachsLuka & The Lights (ALS inzamelingsactie)Peaky Blinders Seizoen 6 op NetflixVoyeur op NetflixVergeet Obi-Wan Kenobi niet!Floris BotGa naar de kwekerZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Een poosje geleden besloot de Europese Commissie dat Russia Today (RT) en Sputnik in de EU verboden zouden worden. Aanvankelijk leek het erop dat alleen de televisiekanalen uit de lucht moesten worden gehaald. Dat zou voor Nederland weinig impact hebben, gezien eigenlijk niemand de kanalen in het pakket had zitten. Al snel werd duidelijk dat ook internetproviders de toegang tot de betreffende websites onmogelijk moesten maken en alle andere vormen van openbaarmaking gestaakt moesten worden. Als voorbeeld: ook VPN-diensten zijn verplicht de sites te blokkeren.Een aantal internetproviders, de Nederlandse Vereniging van Journalisten (NVJ), het Persvrijheidsfonds en burgerrechtenorganisatie Bits of Freedom stappen naar het Europese Hof van Justitie. Ze vragen de rechter de blokkade te beoordelen omdat de manier waarop die tot stand kwam ‘de rechtstaat raakt'. De partijen noemen zich te samen de ‘Freedom of Information Coalition' en benadrukken daarbij met klem geen liefde te voelen voor RT en Sputnik. De huidige blokkade is volgens hen echter censuur en zou volgens democratische principes tot stand moeten komen.Gerdien Dalmulder werkt als Directeur Operations bij Freedom Internet en is een belangrijke speler in de FOIC. Wij spreken haar over de blokkade, de rechtszaak en als ze er toch zit: misschien nog even over hoe het met Freedom gaat.ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt, afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT.Tijdschema00:00:00 Een trotse start00:05:08 Voorstellen: Gerdien Dalmulder00:08:09 De blokkade van RT en Sputnik00:20:03 Een blokkade zonder democratisch proces00:37:00 Het Barbra Streisand effect00:47:49 Hoe gaat het met Freedom Internet?01:02:38 Reclame: Calco01:04:47 Vragen van de luisteraars01:25:49 Tips01:46:14 AfkondigingTipsSander BijleveldAiralo eSIMs in het buitenlandStranger Things playlists op SpotifyBoerderij van Dorst playlist op SpotifyGerdien DalmulderYakkay stijlvolle fietshelmenBevrijd kinderen uit de digitale wurggreepRandal PeelenDe Bier Exchange op onze SlackBoerderij van DorstHeeft omroep Ongehoord Nederland vrij spel? van NRC VandaagFloris BotTehran op Apple TV+Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Je merkt het steeds vaker, we zitten met z'n allen in een bus die gestaag op een afgrond afrijdt, en niemand lijkt er iets aan te willen doen. Dan hebben we het natuurlijk over: 112 of 911 bellen als je in het buitenland op reis bent. Want de VoLTE-standaarden laten enorm te wensen over en internationaal worden steeds meer 2G / 3G netwerken afgeschakeld. Om dat probleem een beetje te duiden: over 3 jaar is de kans dat een willekeurige toerist in de VS met diens mobiel 911 kan bellen nog maar 10%.Een gierput aan ellende die dieper is dan jij nu denkt. Maar gelukkig weet onze gastnerd Rudolf van der Berg hier alles van. Rudolf is senior consultant voor onderzoeksbureau Stratix en programmamanager 5G en digitale connectiviteit voor VNG. Zijn werkzame leven bracht hem langs meerdere zijdes van de tafel die de telecomsector heet en zodoende kan hij vanuit meerdere invalshoeken praten over bijna alle facetten van telecommunicatie.ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt, afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT.Tijdschema00:00:00 Studiogedoe00:02:14 oorstellen: Rudolf van der Berg00:04:07 Waarom jij straks geen 911 kunt bellen00:09:03 Waarom doet niemand er iets aan?00:25:56 Wie moeten de standaarden gaan fixen?00:39:34 Is het echt zo erg?01:01:46 Reclame: Calco01:03:38 Vragen van de luisteraars01:19:48 Tips01:46:03 AfkondigingTipsRuurd SandersEerlijke BankwijzerGreenPCGamer op YoutubeLone EchoSchool Police Last Week Tonight with John OliverWitlof: the MovieRudolf van der BergJoep Beving“Maar dat mag je niet zeggen” boek van Nikki SterkenburgHoe de FLAG kabel tussen Engeland en Japan werd gelegd , zoals beschreven door Neal Stephenson in WiredMin EZK publiceert Stratix rapporten over zeekabelsHow the Net works, over peering en transitJurian UbachsStranger Things seizoen 4HeardleHoordleTweakers Dev SummitRandal PeelenTHE INSIDE OUTTAKES - Bo Burnham (4K)Gun Violence in America - Sam HarrisZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
ve-spa-sià-no /Orinatoio pubblico in forma di edicola. Calco del francese vespasienne, dal nome dell'imperatore romano Vespasiano.Testi di unaparolaalgiorno.itSito: https://unaparolaalgiorno.it/Instagram: https://www.instagram.com/unaparolaalgiorno_it/Una produzione BonfireSito: https://bonfire.landInstagram: https://www.instagram.com/bonfire_land/
Deze aflevering noemen we liefkozend “De Reünie”. Dus dan weet je het wel: Daniel Kegel en Joost Schellevis schuiven terug aan onze tafel voor een gezellig weerzien van alle oprichters van Met Nerds om Tafel.Daniel Kegel, Floris Bot, Joost Schellevis, Jurian Ubachs én Randal Peelen in één aflevering!ReclameCalco is sponsor van deze aflevering. Calco biedt traineeships aan voor starters op de arbeidsmarkt. Afstudeerders of mensen met een paar jaar werkervaring die carrière willen maken in de IT. Tijdschema00:00:00 Hoe Spa Rood is ontstaan00:04:54 Voorstellen: Daniel en Joost00:05:36 Hoe gaat het met Daniel en Joost?00:20:21 Het licht is eindig00:23:15 Favoriete MNOT-momenten00:25:24 Hoe gaat het met Joost's zonnepanelen?00:47:30 Aannemers zijn kut en de crash komt eraan01:07:43 Reclame: Calco01:09:58 Vragen van de luisteraars01:34:16 Tips01:54:36 AfkondigingTipsDaniel KegelThe Nineties: A Book door Chuck KlostermanHow Real Is It? serie van InsiderFloris BotRace - Bubba Wallace op Netflix Koop een elektrische bakfiets.Joost Schellevis15 Piek van De HardheidNeem zonnepanelenHome Assistant voor je energie-dashboardDe Mol (WIDM maar dan uit België)HBO MaxHonkbal.netJurian UbachsElden Ring (dunkview)Randal PeelenTuna on Toast PodcastYC advises founders to ‘plan for the worst' amid market teardownZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
Your bluetooth will sign an armistice when HLS dives deep into the pain of actually doing a podcast, what's real and what's fake, the difference from being liked or making people think, discover OBE has nothing new to add even despite the perspective of time, hear friend of the show, and Pulpo Warrior's Calco's friend, behind the scenes no-shows, dropped balls and lack of communication, the wives, sisters weigh in, how Chumahan's anger bank account is low due to an overdraft on snappage, how Schwartz keeps driving Chumahan nuts, the curse of the Schwartz caused Rachel Sterling to have an allergic reaction. BONUS: HEAR OBE'S MOST HORRIFIC DISGUSTING VIDEO HE SENT CHUMAHAN.Support this podcast at — https://redcircle.com/the-hard-luck-show/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Your earbuds will slap themselves with aftershave when Calco and Marsala hit the bunker to discuss Male Grooming with the Kings of Controversy and the secrets of Pulpo Beard Oil. If you like to stink and are allergic to being handsome do not listen to this! Support this podcast at — https://redcircle.com/the-hard-luck-show/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
In this episode Antonio shares his thoughts on the future of work, including his work in leading an experimental approach, why listening is important in a volatile environment and the business benefits of giving everyone the opportunity to learn. Antonio also describes why all managers are leaders in Diversity, Equity & Inclusion and why we must all remember to take caring approach. Here's a snapshot of a few things we talked about: [4:52] Little actions and changing the way we make decisions [12:00] The beauty of doing something new: reinventing the future [17:30] Learning from the pandemic: the importance of listening [26:38] Empowering all managers to be leaders in Diversity, Equity & Inclusion [27:50] Democratising the opportunity to learn [32:18] The importance of taking a caring approach “I love How HR Leaders Change the World” – if that sounds like you, please consider rating and reviewing our show! This helps us achieve our goal, to reach more of your peers, so we can all contribute to further and faster change. Scroll to the bottom, tap to rate with five stars, and select “Write a Review”. Be sure to let me know what you loved most about the episode! Also, if you haven't done so already, subscribe to the podcast. We'll add a bunch of bonus episodes to the feed and, if you're not subscribed, there's a good chance you'll miss out. Subscribe now!
Awesome Games Done Quick 2021 Online concluded after raising $2.7 million for the Prevent Cancer Foundation. As a host/donation reader, I was fully immersed in the GDQ spirit throughout the week and gained some insight into the choices made by the event organizers. I discuss why incentives are sometimes set high (and then pushed), which donation comments I chose to read, why some donation comments never got to me, and then I go through both of my shifts to discuss how tone changed and what I was attempting to invoke when I was on the microphone. On Wednesday night, during the push for the Zelda: Wand of Gamelon All Cutscene bonus game, I started with Devil May Cry 3 by Waifu. This had hilarious commentary with fast action, high paced gameplay. Zingers flew freely. Immediately after that, the tone shifted to a more relaxing tone with the impressive Super Mario World 2: Yoshi's Island 100% by Calco. Both the runner and commentator Niakky have English as a Second Language and were nervous about having to perform in English. Then, on Friday, it was all about Yakuza 6: The Song of Life by Froob. The main donation incentive here was a Yakuza cutscene called "Rugby Baby." I had not seen the cutscene ahead of time, which influenced how we (Froob and myself) chose to present it to the audience. Also: I do explain where "SpikeVegeta And Crew" came from, and how it was trying to cover myself and not create a bigger flub.
L' autrice tratteggia con eleganza stilistica il doloroso percorso della vita, contrassegnato da una fragilità forse figlia di una malattia che però si manta di forza. Si comprende l' illusione della riuscita e lo sforzo inane della conquistaCredit- autore : Rosanna Spezzati- voce: Alfredo PadalinoVuoi proporti come autore o voce ? Contatta levocidimitico@gmail.com
“Où je vais les arcs-en-ciel coulent sur les bras”. Au-delà du fait que ces paroles de Yelle rayonnent de poésie, je trouve qu'elles collent parfaitement avec l'univers de l'artiste que j'ai rencontrée dans cet épisode. Des couleurs vives, des formes géométriques et des good vibes : le monde de Flore Delage n'en manque pas !Derrière ce nom bourgeonnant se cache une artiste solaire dont les passions créatives s'étendent du stylisme à l'illustration. Autour d'un verre, nous avons abordé son parcours atypique, sa passion pour le kitsch et ses créations vibrantes. De quoi faire le plein d'énergie pour les jours à venir. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out.
I’m not allowed to have favorite episodes and honestly, each one is pretty different. But my interview with Bud Isaacs is certainly one of my favorites. Mines grad, Vietnam vet, a career in oil and gas, lover of the outdoors, and most recently advocate for the water shed on the western slope. The co-authored book- “Oil and Water” is a fascinating dive into the world of water and what keeps 40 million Americans hydrated from the Colorado River. Water is THE crisis of the next 50 years and the book is a pretty powerful introduction to the concepts and thoughts around how society gets its water. Oh yeah, and he, his wife and most of his direct family had COVID in a February. Lots of learnings, insights and just a wonderfully enjoyable day for me to spend with Bud at his house. #hottakeoftheday podcast Episode 59 w/Bud Isaacs https://youtu.be/bsH5CDLiyOs Audio Podcast About Bud Vernon A. (Bud) Isaacs Mr. Vernon A. (Bud) Isaacs, Jr. graduated from the Colorado School of Mines in 1964 with a Professional Degree in Petroleum Engineering. Upon commissioning as a Second Lieutenant, Mr. Isaacs served in the U.S. Army Corps of Engineers, including combat operations in Vietnam with 1st Brigade, 101st Airborne Division, receiving a number of Vietnamese combat ribbons, the Combat Infantry Badge, Silver Star, Bronze Star with Valor, and a Purple Heart for wounds suffered during combat. Following military service, Mr. Isaacs emerged as an industry leader in petroleum engineering. He held positions with Coquina Oil Corporation, Union Oil Company, and CALCO in drilling and production engineering as well as planning and property valuation. Mr. Isaacs joined Petrol-Lewis Corporation in 1976 and accepted a promotion to Senior Vice President of the corporation in 1981. In 1985, he founded V.A. Isaacs and Associates, Inc. to advise companies in the purchase and sale of oil and gas properties, and in 1989, established RIM Companies, a private oil and gas property management firm with production operations across the continental United States. Mr. Isaacs contributes significantly to the community as both a leader and volunteer, serving as the Director of Enduring Resources, LLC; a member and former distinguished lecturer of the Society of Petroleum Engineers; and previously as an Executive Board Member of the Independent Petroleum Association of Mountain States and Chairman of the Coalbed Methane Committee. He is a current member and past President of the Denver Chapter of the Society of Petroleum Evaluation Engineers. Mr. Isaacs has been an active volunteer of Boy Scouts of America and currently serves on its Executive Board. In addition, he is on the Board of Trustees for Denver Inner City Parish, the Development Board for Uplift, and serves as a Trustee for Alliance for Choice in Education. Formerly, he served on the Board of the Winter Olympics Committee, Ski Club Vail, and demonstrated enduring support for the Colorado School of Mines as the Chair of the Reunion Gift Committee and a member of the Student Recreation Center and Marquez Hall Campaign Committees.
Dante Mortet immortalò il suo gesto creativo, la voce di Ennio Morricone colpito dalla perfezione della piccola scultura
Mary Cyn, CalCo and Ellen Acuario share stories about sweater fetishes, waiting for test results and a search for a birth mother.
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- yamaha dd55 drum machine 80 euro novate milanese massimiliano 328 2127991-- mountain bike rossa e bianca CONTI 8 rapporti 100 euro a Calco cesare 333 6037336 - - regalo 3 lampadari + vecchi sci fischer 349 4347936 Maurizio - - prime 3 annate National Geographic Italia regalo in cambio abbonamento Monza Riccardo 334 7754508 - - vende 8 pneumatici (4 estivi 4 invernali) 185-55-R15 Citroen C2 250 euro Giacomo (MI) 335 6890884 (prima parte)
Renata 333-8304210 Milano Sud regala scatole, armadio – Michela 339-8894533 Trenno regala due vaschette per bagnetto, girello, due passeggini in buono stato – Lina 334-5043170 Lambrate, vende bici Graziella richiudibile 160 euro – Cristina 338-9123834 Niguarda, vende tre armadi, tanti libri anni 60/70 – Vittorio 373-8822886 Porta Venezia cerca giri pomeridiani vicino a Porta Venezia – Cesare 333-6037336 Calco, compagnia per canoa – Marta 349-7803957 Milano est, regala letto, cerca scarpe da tip tap da bambina 32/36 (prima parte)
Renata 333-8304210 Milano Sud regala scatole, armadio – Michela 339-8894533 Trenno regala due vaschette per bagnetto, girello, due passeggini in buono stato – Lina 334-5043170 Lambrate, vende bici Graziella richiudibile 160 euro – Cristina 338-9123834 Niguarda, vende tre armadi, tanti libri anni 60/70 – Vittorio 373-8822886 Porta Venezia cerca giri pomeridiani vicino a Porta Venezia – Cesare 333-6037336 Calco, compagnia per canoa – Marta 349-7803957 Milano est, regala letto, cerca scarpe da tip tap da bambina 32/36 (seconda parte)
Renata 333-8304210 Milano Sud regala scatole, armadio – Michela 339-8894533 Trenno regala due vaschette per bagnetto, girello, due passeggini in buono stato – Lina 334-5043170 Lambrate, vende bici Graziella richiudibile 160 euro – Cristina 338-9123834 Niguarda, vende tre armadi, tanti libri anni 60/70 – Vittorio 373-8822886 Porta Venezia cerca giri pomeridiani vicino a Porta Venezia – Cesare 333-6037336 Calco, compagnia per canoa – Marta 349-7803957 Milano est, regala letto, cerca scarpe da tip tap da bambina 32/36 (seconda parte)
Renata 333-8304210 Milano Sud regala scatole, armadio – Michela 339-8894533 Trenno regala due vaschette per bagnetto, girello, due passeggini in buono stato – Lina 334-5043170 Lambrate, vende bici Graziella richiudibile 160 euro – Cristina 338-9123834 Niguarda, vende tre armadi, tanti libri anni 60/70 – Vittorio 373-8822886 Porta Venezia cerca giri pomeridiani vicino a Porta Venezia – Cesare 333-6037336 Calco, compagnia per canoa – Marta 349-7803957 Milano est, regala letto, cerca scarpe da tip tap da bambina 32/36 (prima parte)
Carolyn Castiglia, Maribel Hernández Rivera, Jason Kim and CalCo share stories about R-E-S-P-E-C-T.
Pizza Parlor Guy Jumps Customer -- and Then it Gets WeirdFrom Randy Cassingham's This is True -- http://www.thisistrue.com -- online weird news since 1994.