Podcasts about Castellano

In this episode of Gangland Wire, Gary Jenkins sits down with author Craig McGuire to discuss his gripping book, Empire City Under Siege, a deep dive into three decades of FBI manhunts, mob wars, and organized-crime investigations in New York City. Craig explains how the project grew out of his collaboration with retired FBI agent Anthony John Nelson, whose career spanned the most violent and chaotic years of New York's Mafia history. From Nelson's early days as a radio dispatcher in 1969 to his transition into undercover and frontline investigative work, the book captures the gritty reality of law enforcement during the 1970s and 1980s. We explore how Nelson's career mirrored the evolution of organized crime and law-enforcement tactics, including the rise of undercover stings, inter-agency cooperation, and the increasing role of technology. Craig highlights the close working relationship between Nelson and NYPD detective Kenny McCabe, whose deep knowledge of Mafia families and quiet professionalism led to major breakthroughs against organized crime. He tells how these two investigators wathced and uncovered the Gambino Family Roy DeMeo crew under Paul Castellano and Nino Gaggi. Throughout the conversation, Craig shares vivid, often humorous slice-of-life stories from the book—tense undercover moments, dangerous confrontations, and the emotional toll of living a double life. These anecdotes reveal not only the danger of the job but also the camaraderie and resilience that sustained agents and detectives working in the shadows. The episode closes with a reminder that Empire City Under Siege is as much about honoring unsung law-enforcement professionals as it is about mob history. Craig encourages listeners to support true-crime storytelling that preserves these firsthand accounts before they're lost to time. Hit me up on Venmo for a cup of coffee or a shot and a beer @ganglandwire Click here to “buy me a cup of coffee” Subscribe to the website for weekly notifications about updates and other Mob information. To go to the store or make a donation or rent Ballot Theft: Burglary, Murder, Coverup, click here To rent ‘Brothers against Brothers’ or ‘Gangland Wire,’ the documentaries click here.  To purchase one of my books, click here. 0:02 Welcome Back to Gangland Wire 2:14 The Journey to Anthony John Nelson 4:46 The Life and Work of Law Enforcement 15:00 Inside Anthony Nelson’s Early Career 26:49 The Dynamic Duo: Nelson and McCabe 30:16 Tales from the Underworld 35:55 The Tragedy of Everett Hatcher 39:12 The High-Stakes World of Undercover Work 40:56 Closing Thoughts and Inspirations transcript [0:00] Hey, all you wiretappers. Good to be back here in studio of Gangland Wire. I say the same thing every time. I hope it doesn’t bore you too much, but I am back here in the Gangland Wire studio. And I have today an author who interviewed and wrote a book with an FBI agent named Anthony John Nelson, who was one of the premier FBI agents in New York City that was working the mob. And even more interesting about him to me was he formed a partnership with a local copper named Kenny McCabe, who you may know the name. I had read the name before several times as I started researching this and looking at the book, but he was a mob buster supreme and Agent Nelson really formed a dynamic duo. But first, let’s start talking to Craig, your book, Empire City Under Seize, Three Decades of New York FBI Field Office Manhunts, Murders and Mafia Wars. How did you get involved with Anthony John Nelson? [0:55] Hi, Gary. Thanks for having me on your show. Big fan. Appreciate the opportunity. Very interesting and winding path that led me to Anthony’s doorstep. I also previously wrote another book, Carmine and the 13th Avenue Boys, which was about an enforcer in the Colombo family during the Third Colombo War. And I was introduced to Carmine Imbriali through Thomas Dades. Tommy Dades, he’s a famous retired NYPD detective. So after the success of that book, Tommy introduced me to another member of law enforcement. I started to work on a project that sort of fell apart. And one of the sort of consultants, friends that I met with during that was Anthony Nelson. And then one day as that, due to my own fumbling, as that project was falling apart, I had a delightful breakfast with Anthony and his wonderful wife, Sydney, Cindy, one Sunday morning. And Anthony’s pulling out all these clips of all these investigations and all these Jerry Capiche gangland clips. And it was just fascinating. And so I started to realize that there’s something here because I’m also a true crime fan and I remember many of these cases. [2:08] So it took a while to get Anthony to agree to write a book. He’s not one for the spotlight. He’s really your sort of quintessential G-man, modern G-man. It’s also somewhat of a throwback. But he eventually was interested in doing a book if we didn’t just shine the spotlight on him. Gary, you should know the original, the working title of the book was In the Company of Courage. And that’s really the theme that Anthony wanted to bring forth. You’ll notice throughout the book, there are some vignettes and some biographical information about many of the members of law enforcement that I interviewed, but then we also covered and who are no longer with us. It was my privilege to write this book sharing Anthony’s amazing history, 30 years at the FBI and then several years at the Brooklyn District Attorney’s Office as an investigator. And just like one of the themes is just to really shed some light on the valuable work that members of law enforcement, including you, sir. Thank you for your service. And we think too often these days, members of law enforcement are maligned and there’s a negative light cast on them. It’s the most difficult job in the world. And we just want to make sure that we’re shining some light on that valuable work that the thousands of members of men and women in law enforcement do every day protecting us. [3:24] I appreciate that. I’ll tell you what, all the way from the rookie on the street making those domestic violence calls and party armed calls and armed robbery alarms calls that are, there’s nothing there the first five times you go. And then all of a sudden there’s a guy running out with a gun all the way up to the homicide detectives. And even the people that handle the budget, they all paid their dues out on the streets and organized crime investigators, of course, and narcotics. I really appreciate that. It’s a thankless job for the most part. Once in a while, you get a little thanks, but not much. As we used to say, it was fun. I can’t believe they pay us to do this. [4:01] Gary, it’s like you’re repeating some of the lines of Frank Pergola to Al King, just like that. And that’s key, that thankless piece. I remember interviewing Frank Pergola, just famous New York City detective, worked on Son of Sam. He also worked on solving 79 homicides related to the Gambinos and the DeMeo family. And he echoed those same sentiments. While you’re investigating a case, it’s the victims’ families and the victims, their nerves are so fraught. It’s such a stressful situation. And the members of law enforcement bear the brunt of a lot of that frustration. [4:41] And too often, there’s no thank you at the end. And it’s not that they want to thank you. It’s just that they want the sort of closure, not even the recognition, just some sort of realization that they did a great job. And it’s unfortunate that they don’t, that doesn’t happen as often as it should. I appreciate it. Let’s talk about Anthony Nelson. He sounds like a very interesting character. Talk a little bit about what you learned from him about his early career. And I want to tell you something, that recalcitrance, I believe that’s the word, $25 word if I’ve ever heard one. His refusal to really make himself a hero or the center of attention. That’s pretty common among cops and FBI agents. I’ve noticed we’ve got, I’ve got a good friend here in Kansas City, wrote a book about the mafia in Kansas City called Mopsers in Our Mist, but he refused to put himself into the book. He had a publishing company that wanted him to do it and was going to pay him to do it, but it had to have him as a hero. He said, we have to have a hero in this book. He says, I won’t do it. So that Mr. Nelson, Agent Nelson, that’s not that uncommon. So tell us a little more about some of his early cases. [5:49] Anthony Nelson, interestingly enough, his career trajectory and really his life tracks with the latter half of the last century. And a lot of the technological evolution, the rise of organized crime post-prohibition, these themes of urbanization, radicalization that came out from the starting in the middle of the century. But really heating up as a young Anthony Nelson joins the FBI in 1969, really mostly in administrative roles, radio dispatcher first, eventually he’s an electronics technician. So I’m sure, Gary, you can reflect on, and some of this will resonate with you, just how archaic some of the technology was. Oh my God, yeah. Yeah. Back then, we have some fantastic anecdotes and stories in the book, but just also like, for example, when you’re responding to a hostage crisis and you don’t have a cell phone, you don’t have minimal communications and talking about, you better make sure you have a pocket full of dimes and knocking on a neighbor’s door because time is of the essence and to establish contact. So just some of this great, really interesting material there. Eventually, Anthony was sworn in as an agent in 1976, and he entered the FBI Academy at Quantico, graduated in 77. [7:13] And interestingly enough, Anthony reflects like some of his fellow graduates, perhaps were not as keen on going to New York, one of the larger field offices, perhaps wanting to cut their teeth at a smaller office, but he obviously wanted to go home. So he was, and he jumped right into the fray, really assigned to hijacking. And he was an undercover operative in Red Hook during the 1970s, like the really gritty. And from the stories and from the various folks I interviewed, this really was gritty New York back then with the economy failing, crime on the rise. [7:48] Gary, you look, I heard an interesting stat last week where you had, there was almost a record setting that New York City had not reported a homicide for a record 12 consecutive days. And that had not happened in decades. So when Anthony joined the FBI, they were recording five homicides in New York City. And also during the 70s, you also had this, when you talk about radicalization, with 3,000 bombings nationwide, corruption was rampant. You had credit card fraud was just kicking off. You had widespread bread or auto theft and hijacking. Again, at the street level, Anthony was the front for a Gambino-affiliated warehouse where he had first right of refusal, where some of the hijackers would bring in the loads. And he was doing this on an undercover basis. So he jumped right in. They set him up in a warehouse and he was buying like a sting, what we called a sting operation. He was buying stolen property. They thought he was a fence. [8:50] Yeah, they started doing that in the 70s. They hadn’t really done, nobody had done that before in the 70s. ATF kind of started sting operates throughout the United States. We had one here, but they started doing that. And that was a new thing that these guys hadn’t seen before. So interesting. He was that big, blurly guy up front said, hey, yeah, bring that stuff on. Exactly. If you look on the cover, there are three images on the cover, and one of them is following one of the busts afterwards where they tracked down the hijacked goods. I believe it was in New Jersey. So you could get the sense of the volume. Now, think about it like this. So he’s in Red Hook in the mid-70s. This was actually where he was born. So when Anthony was born in 49, and if you think about Red Hook in the early 50s, this was just a decade removed from Al Capone as a leg-breaking bouncer along the saloons on the waterfront. And this was on the waterfront, Red Hook eventually moved to Park Slope. [9:49] And this was where Crazy Joe Gallo was prompted, started a mob war. And this was when any anthony is coming of age back then and most of his friends is gravitating so to these gangster types in the neighborhood these wise guys but this was a time pre-9-1-1 emergency response system so the only way to report or get help was to call the switchboard call the hospital directly call the fire department directly so you had the rise of the b cop where it wasn’t just the police they were integral part of the community and there’s this really provocative story Anthony tells the first time he saw a death up close and personal, an acquaintance of his had an overdose. And the beat cops really did a sincere effort to try to save him. And this really resonated with the young Anthony and he gravitated towards law enforcement. And then a little bit, a while later as a teenager, they’re having these promotional videos, these promotional sort of documentary style shows on television. And Anthony sees it, and he’s enamored by it, especially when they say this is the hardest job in America. So he’s challenged, and he’s a go-getter. So he writes a letter to J. Edgar Hoover, and Hoover writes him back. [11:03] So it’s a signed letter, and now Anthony laughs about it. He says it was probably a form letter with a rubber stamp, but it really had an amazing impact. And this is at the time when, you know, in the 50s, you really had J. Edgar really embrace the media. And he actually consulted on the other famous, the FBI television show, several movies, the rise of the G-Man archetype. So Anthony was fully on board. [11:28] Interesting. Of course, J. Edgar Hoover wanted to make sure the FBI looked good. Yes, exactly. Which he did. And they were good. They had a really high standards to get in. They had to be a lawyer or accountant or some extra educated kind of a deal. And so they always think, though, that they took these guys who had never been even a street policeman of any kind and they throw them right into the DPN many times. But that’s the way it was. They did have that higher level of recruit because of that. So, Anthony, was he a lawyer or accountant when he came in? Did he get in after they relaxed that? Oh, that’s spot on. I’m glad you brought that up. So now here’s a challenge. So Anthony needs that equalizer, correct? So if you’re a CPA, obviously a former member of the military, if you’re a successful detective or a local police force, one of these type of extra credentials. [12:20] Anthony’s specialty was technology. Now, when you think of technology… Not the ubiquitous nature of technology nowadays, where you have this massive processing power in your phone, and you don’t really have to be a technologist to be able to use the power of it. This is back in the 1960s. But he always had an affinity for technology. And he was able to, when he, one of the other requirements was as he had to hit the minimum age requirement, he had to work for a certain amount of time, he was able to get a job at the FBI. So he was an electronics technician before he became an agent. [12:59] And he had all of the, and back then this was, it was groundbreaking, the level of technology. And he has some funny story, odd, like man on the street stories about, I’m sure you remember Radio Shack when there was a Radio Shack on every other corner, ham radio enthusiasts. And it was cat and mouse. It was, they had the members of organized crime had the police scanners. And they were able to, if they had the right scanner, they had the right frequency. They were able to pick on the bugs planted really close to them. And he tells some really funny stories about one time there was a member of organized crime. They’re staking out, I believe it was the cotillion on 18th Avenue. And then I believe he’s sitting outside with Kenny McCabe. And then one of this member of organized crime, he’s waving a scanner inside and he’s taunting them saying, look, I know what you’re doing. And so it was that granularity of cat and mouse. [13:55] Rudimentary kind of stuff. Yeah. We had a guy that was wearing what we called a kelk kit. It was a wire and he was in this joint and they had the scanner and so but they had to scan her next door at this club And all of a sudden, a bunch of guys came running and there’s somebody in here wearing a wire. And my friend’s guy, the guy I worked with, Bobby, he’s going, oh, shit. And so he just fades into the background. And everybody except one guy had a suit on. Nobody had a suit on except this one guy. So they focused on this one guy that had a suit on and went after him and started trying to pat him down and everything. Bobby just slipped out the front door. So amazing. I mean, you know, Anthony has a bunch of those slice of life stories. I also interviewed a translator from the FBI to get a sort of a different perspective. [14:42] It’s different. Like the agents a little bit more, they’re tougher. They’re a tougher breed. They go through the training. Some of the administrative professionals, like the translators. So this one translator, it’s a pretty harrowing experience because remember the such the insular nature of the neighborhoods and how everyone is always [14:59] looking for someone out of place. So she actually got a real estate license and poses a realtor be able to rent apartments and then she spoke multiple dialects and then just to have to listen in and to decipher not only the code but also the dialects and put it together when you have agents on the line because remember you have an undercover agent if they get discovered more often than not the members of organized crime are going to think they’re members of another crew so you’re dead either they’re an informant if they think they’re an informant you’re dead if they think you’re an agent yeah just turn away from you say okay we don’t deal with this guy anymore if you think you’re informant or somebody another crew or something trying to worm their way in then yeah you’re dead exactly so interviewing maria for this you get that sense from someone who’s not in like not an agent to get true how truly harrowing and dangerous this type of activity was and how emboldened organized crime was until really the late 90s. And back then, it truly was death defying. [16:02] Oh, yeah, it was. They had so many things wired in the court system and in politically in the late 70s and early 80s and all these big cities. No big city was immune from that kind of thing. So they had all kinds of sources. They even had some clerks in the FBI and they definitely had all the court. The courthouses were just wired. And I don’t mean wired, but they had people in places and all those things. So it was death to find that you got into these working undercover. Ever. Hey, you want to laugh? I don’t want to give away all the stories, but there was a great story. I remember Anthony saying, they set up a surveillance post in an apartment and they brought in all the equipment while they were, then they got the court orders and the surveillance post actually got ripped off twice. So while they try, like after hours, someone’s going, yeah, ripping off all the FBI equipment. So you have this extra level of, so that gives you like, It really was Wild West then. Really? [17:00] So now he gets into organized crime pretty quick, into that squad and working organized crime pretty quick. I imagine they put him in undercover like that because of his accent, his ability to fit in the neighborhood. I would think he would have a little bit of trouble maybe running into somebody that remembered him from the old days. Did he have any problem with that? I spot on, Gary. I tell you, this was he. So he’s operating in Red Hook and actually throughout the next several years, he’s periodically flying down to Florida as a front for New York orchestrated drug deals. So he’s going down to Florida to negotiate multi-kilo drug deals on behalf of organized crime. But at the same time, he’s an agent. He eventually rose to be supervisory special agent. He’s managing multiple squads. So there did come an inflection point where it became too dangerous for him to continue to operate as an undercover while conducting other types of investigations. [18:02] Interestingly enough they opened up a resident agency office the ras are in the major field offices in the fbi they have these they’re called ras i’m sure you’re familiar these like mini offices with the office and they’ll focus on certain areas of crime more geographically based so they opened up the brooklyn queens ra and that really focuses heavily on organized crime but also hijacking because you had the, especially with the airport over there and a lot of the concentrations of, especially in South Brooklyn, going into Queens. So he worked there. Also the airport. Also the mass, you have this massive network of VA facilities. You have the forts. So you need these other RA offices. So you have a base of operations to be able to investigate. But Anthony has such a wide extent of case history, everything from airline attacks to art theft heists to kidnappings, manhunts, fugitives. There was Calvin Klein, the famous designer, when his daughter was kidnapped by the babysitter, it did do it. Anthony was investigating that. So it’s just, and while he has this heavy concentration in organized crime. I mentioned that. What’s this deal with? He investigated a robbery, a bank robbery that was a little bit like the dog day afternoon robbery, a standoff. What was that? [19:30] This was actually, it was the dog day afternoon robbery. They based a dog day afternoon on this. Exactly. What you had, and this was before Anthony was when he was still in his administrative role. So he had a communications position. So he was responsible for gathering all the intel and the communications and sharing it with the case, the special agents on site. So what you had was like, he’s with the play by play of this really provocative hostage. It was a bank robbery that quickly turned into a hostage crisis. And then, so throughout this whole, and the way it eventually resolved was the perpetrators insisted on a particular agent. I apologize. It slips my mind, but he’s a real famous agent. So he has to drive them to JFK airport where they’re supposed to have a flight ready to fly them out of the country. And what happens is they secrete a gun into the car and he winds up shooting the bank robbers to death. And there were so many different layers to this bank robbery. It eventually became the movie. And a funny story aside, the movie, while they’re filming the movie, Anthony’s at his friend’s house in downtown Brooklyn. It may have been Park Slope. And they’re calling for extras. His friends run in and say, hey, they’re filming a movie about this bank robbery that happened on Avenue U. You want to be an extra? And he said, nah, no thanks. The real thing was enough for me. [20:55] I’ll tell you what, it wasn’t for a New York City organized crime and New York City crime. Al Pacino wouldn’t have had a career. That’s the truth. [21:05] Now, let’s start. Let’s go back into organized crime. Now, we’ve talked about this detective, Kenny McCabe, who was really well known, was famous. And during the time they worked together and they were working with the Brooklyn District Attorney’s Office. Is that correct? Were both of them working for it? Was he at the FBI and Kenny was with the Brooklyn DA’s office? [21:26] When you think about thematically, in the company of courage, Kenny McCabe was really close. This was a career-long, lifelong, from when they met, relationship, professional relationship that became a deep friendship between two pretty similar members of law enforcement. [21:46] Kenny McCabe had a long career in the NYPD as organized crime investigator before he joined the Southern District Attorney’s Office as an investigator. So the way they first crossed paths was while Anthony was working a hijacking investigation. So he gets a tip from one of his CIs that there’s some hijacked stolen goods are in a vehicle parked in a certain location. So he goes to stake it out. Like they don’t want to seize the goods. They want to find out, they want to uncover who the hijackers are and investigate the conspiracy. So then while he’s there, he sees a sort of a familiar face staking it out as well. Then he goes to the, he goes to the NYA, a detective Nev Nevins later. And he asks about this guy. And so this detective introduces him to Kenny McCabe and right away strike up with his interesting chemistry. And they’re like, you know what? Let’s jointly investigate this. So they wind up foiling the hijacking. But what starts is like this amazing friendship. And I’ll tell you, the interesting thing about Kenny McCabe is almost universally, he’s held in the highest regard as perhaps law enforcement’s greatest weapon in dismantling organized crime in the latter half of the 20th century. For example, I interviewed George Terra, famous undercover detective who eventually went to the Brooklyn District Attorney’s Office. [23:12] And he had a great way. I hope I don’t mangle. Kenny knew all the wise guys and they all knew Kenny. And when I say he knew all the wise guys, he knew their shoe sizes. He knew who they partnered with on bank jobs years ago. So he knew who their siblings were, who their cousins were, who they were married to, who their girlfriends were, what clubs they frequented. For example, during the fatical hearings, where they would do sentencing, often the defense attorneys would want the prosecutors to reveal who their CIs are for due process, for a sense of fairness. And they refused to do that, obviously, for safety reasons, and they want to compromise ongoing investigations. So in dozens, perhaps so many of these cases, they were bringing Kenny McCabe. He was known as the unofficial photographer of organized crime. [24:07] For example, I think it was 2003, he was the first one who revealed a new edict that new initiates into Cosa Nostra had to have both a mother and a father who were Italian. Oh, yeah. I remember that. Yeah. He was also, he revealed that when the Bonanno family renamed itself as Messino, he was the one who revealed that. And then when Messino went to prison for murder, his successor, Vinnie Bassiano, Vinnie gorgeous. When he was on trial, that trial was postponed because so many of law enforcement leaders had to attend Kenny McCabe’s funeral, unfortunately, when he passed. So this is such a fascinating thing. Now, why you don’t hear more about Kenny McCabe, and I interviewed his son, Kenny McCabe Jr. Duke, is like Kenny McCabe like really issued the media spotlight. He would not, he wasn’t interested in grabbing the microphone. So you have almost no media on Kenny McCabe. If you do a Google search for him, I believe the only thing I ever found was a picture in his uniform as an early career police officer. [25:19] So it’s really hard to even do a documentary style treatment without having any media because B-roll is just going to get you so far. So really what Duke has been doing over the last two decades or more is really consolidating all of these as much material as he can. And I think eventually when he does put out a book, this thing’s going to explode. It’s going to be like true Hollywood treatment. But now going back to the mid-70s, so these two guys hook up. You have the FBI agent and you have the police detective. [25:49] Craig, what you always hear is that the FBI is suspicious and doesn’t trust local authorities. And local policemen hate the FBI because they always grab all the glory and take everything, run with it. And they’re left out. And I didn’t have that experience myself. They’ve got the case. They’ve got the laws. We don’t locally, county and statewide, you don’t have the proper laws to investigate organized crime. Yes, sir. But the feds do. So that’s how it works. This really blows that myth up that the local police and the FBI never worked together and hated each other. [26:25] I’m so glad you brought that up because this was very important to Anthony. He has so many lifelong friends in the NYPD, and I’ve interviewed several of them. And just this sincerity comes across, the camaraderie. In any walk of life, in any profession, you’re always going to have rivalries and conflict, whether healthy conflict or negative conflict. [26:46] Even more, you’re going to find that in law enforcement because the stakes are so high. But it’s a disservice to… And what we want to do is sort of dispel the myth that there was no cooperation. Why there were very well-publicized conflicts between agencies prosecuting certain cases. This was the time where technology was really enabling collaboration. Remember, and you had a time, if you had to investigate a serial crime, you had to go from jurisdiction to jurisdiction and you had to interview investigators. You had to comb through written records to piece this together. So it really was not conducive for collaboration. [27:22] So what you saw was the rise of, and then you had these investigative tools and these legal tools like RICO, while they were still trying to figure out and to build. So now you had the litigious tools where you could build conspiracies and prosecute them. So this sort of helped ferment this sort of collaborative interagency, which eventually led to these joint task force that were very successful. What I really love is this microcosm of Anthony Nelson and Kenny McCain. Now, Anthony Nelson was issued a Plymouth Grand Fury with the full police interceptor kit. If you’re familiar with that make and model, no automobile ever created screams cop-mobile like the Grand Fury. And so what you had was after hours, Anthony and Kenny would join up and they would go prowling the underworld with the Grand Fury on purpose. They wanted to be as conspicuous as possible. to the point where they would park in bus stops across the street from these social clubs. And when I say social clubs, they were… [28:29] Everywhere. There were dozens of them all over Brooklyn and Queens. And these are cafe, social clubs, bars, restaurants with heavy OC presence, blatantly conducting their business. So you have these two, Anthony’s always driving. Kenny’s always riding shotgun with his camera. I assume it was some sort of 35 millimeter hanging out the side, taking down names, license plates. Just a great story. You had Paul Castellano in front of Veterans and Friends on 86th Street when he had Dominic Montiglio start that social club so he could have more of a presence in Brooklyn on the street so that he actually crosses the street and he goes to Kenny and Anthony. And he’s saying, guys, you don’t have to sit out here. You could come down to Ponte Vecchio in Bay Ridge. I have a table there anytime you want to talk to me. So it’s that level of bravado. But pretty soon it changed. Once more of this intel started to build these real meaningful cases, Castellana put an edict, don’t talk to these two, don’t be photographed. What came out of that was an amazing partnership where they gathered so much intelligence and Anthony is very. [29:46] Quick to have me point out, give more credit to the investigators, to the agents, to the detectives. They gathered a lot of the intelligence to help with these investigations, but you had so many frontline folks that are doing a lot of the legwork, that are doing the investigations, making the arrests, that are crawling under the hoods. So it’s pretty inspiring. But then you also had some really good, and I don’t want to share all the stories [30:12] in the book. There’s a great story of Kenny and Anthony. They go into Rosal’s restaurant because they see this. [30:21] There may have been a warrant out on this member of law enforcement. So they had cause. So they go in and there’s actually some sort of family event going on. And they’re playing the theme song of The Godfather. As they go in and then they have to go into the back room to get this member of organized crime who’s hiding. So it’s these kind of really slice of life kind of stories that just jump out, jump out of the book. Really? I see, as I mentioned, they had some kind of a run-in with Roy DeMeo at the Gemini. You remember that story? Can you tell that one? Yeah, there’s, so Kenny and Anthony, throughout the hijacking investigations. [30:59] Were, they were among the first to really learn of this mysterious Roy. And his rise. And then also Nino. Remember Nino Gadgi was the Gambino Capo who took over Castellano’s crew, Brooklyn crew, when he was elevated. And then Roy DeMeo was really this larger than life maniac serial killer who formed the Gemini crew, which was a gang of murderers really on the Gemini Lounge in Flatlands, which is really close to Anthony’s house. And Kenny’s not too far. Didn’t they have a big stolen car operation also? Did they get into that at all? Yes. Stolen cars, chop shops. Remember, this is when you had the introduction of the tag job, where it was relatively easy to take the vehicle identification numbers off a junked auto and then just replace them with the stolen auto, and then you’re automatically making that legitimate. And then, so they’re doing this wholesale operation where they’re actually got to the point where they’re shipping hundreds, if not thousands of these tag jobs overseas. So it was at scale, a massive operation. Roy DeMay was a major earner. He was such an unbalanced, very savvy business for the underworld, business professional, but he was also a homicidal maniac. [32:22] Some say they could be upwards of a hundred to 200 crimes. Frank Pergola alone investigated and So 79 of these crimes associated with this crew. And it got to the point where, and he had a heavy sideline in drugs, which was punishable by death in the Gambino family, especially under Castellano. So then what you had was all these investigations and all this intelligence that, and then with this collaboration between the FBI and NYPD. Oh, wow. It is quite a crew. I’m just looking back over here at some of the other things in there in that crew in that. You had one instance where there was a sentencing hearing and of a drug dealer, I believe, a member of organized crime. And Kenny McCabe is offering testimony to make sure that the proper sentencing is given because a lot of times these guys are deceptive. [33:16] And he mentions DeMeo’s name. So DeMeo in a panic. So then maybe a couple of nights later, they’re parked in front of veterans and friends. And DeMeo comes racing across 86th Street. Now, 86th Street is like a four-lane thoroughfare. It’s almost like, oh, I grew up in the air a few blocks away. So he’s running through traffic. And then he’s weaving in and out. And he’s screaming at Kenny McCabe, what are you trying to kill me? Putting my name into a drug case? They’re going to kill me. And so it’s that kind of intimate exchanges that they have with, with these key members of organized crime of the era. [33:52] Wow. That’s, that’s crazy. I see that they worked to murder that DEA agent, Everett Hatcher, that was a low level mob associate that got involved in that. And then supposedly the mob put out the word, but you gotta, we gotta give this guy up. But you remember that story? Now, this is another instance where I remember this case. And I remember afterwards when they killed Gus Faraci. So what you had was, again, and this is very upsetting because you had DEA agent Everett Hatchard, who is a friend of Anthony’s. To the point where just prior to his assassination, they were attending a social event together with their children. And he would also, they would run into each other from time to time. They developed a really beyond like camaraderie, like real friendship. So then, so Hatcher has, there’s an undercover sting. So there’s Gus Faraci, who’s, I believe he was associated with the Lucchese’s, with Chile. [34:55] So he gets set up on the West Shore. And so he’s told to go to the West Shore Expressway. Now, if you’ve ever been on that end of Staten Island, that whips out heading towards the outer bridge. This really is the end of the earth. This is where you have those large industrial like water and oil tankers and there’s not really good lighting and all this. It’s just like a real gritty. So he loses his surveillance tail and they eventually, he’s gunned down while in his vehicle. So then Anthony gets the call to respond on site to investigate the murder. He doesn’t know exactly who it is until he opens up the door and he sees it’s his friend. And this is the first assassination of a DEA agent. It was just such a provocative case. And the aftermath of that was, again, like Gus Faraci, who was, he was a murderer. He was a drug dealer, but he did not know. He set him up. He thought he was a member of organized crime. [35:53] He was just another drug dealer. He did not realize he was a DEA agent. And then all hell broke loose. And you had just the all five families until they eventually produced Gus Faraci, set him up, and then he was gunned down in Brooklyn. [36:06] Case closed, huh? Exactly. Yeah. And as we were saying before, I don’t remember it was before I started recording or after that. When you’re working undercover, that’s the worst thing is they think that you’re an informant or a member of another crew and you’re liable to get killed. At one say, I had a sergeant one time. He said, if you get under suspicion when you’re like hanging out in some of these bars and stuff, just show them you’re the cops. Just get your badge out right away because everything just, all right, they just walk away then. It’s a immensely dangerous thing to maintain your cover. Yes, sir. Anthony was always good at that because tall gentleman has the right sort of Italian-American complexion. He’s passable at Italian. So with some of these folks, especially from Italy that come over, he could carry a conversation. He’s not fluent. [36:56] And he just walks in and talks in. It’s a different… George Terror was a fantastic undercover detective. And you talk to some of these undercovers, it’s like you have to be… There’s sort of this misperception that the organized crime members are like these thugs and flunkies. These are very intelligent, super suspicious, addled individuals that are able to pick up on signals really easy because they live on the edge. So you really can’t fake it, the slightest thing. And again, they’ll think that their first inclination is not that you’re a member of law enforcement. Their first inclination is that you’re a member of a rival crew that’s looking to kill me looks at looking to rip me off so i’m going to kill you first it’s just it’s just a wild and imagine that’s your day job oh man i know they could just and i’ve picked this up on people there’s just a look when you’re lying there’s just a look that just before you catch it quick but there’s a look of panic that then you get it back these guys can pick up that kind of stuff just so quickly any kind of a different body language they’re so good with that. [38:02] And he’s also, he has to be able to say just enough to establish his connection and credibility without saying too much that’s going to trip him up. And that’s like being able to walk that line. He tells, again, I hate giving away all these stories because I want readers to buy the book, but he has this fantastic story when he’s on an undercover buy and he’s, I don’t know if it’s Florida, if it’s Miami or it’s Fort Lauderdale and he has to go into a whole, like the drugs are in one location and he’s in that with the drug deals in one location and he’s in this location and, but he knows the money’s not going to come. [38:42] So he has to walk into this hotel room with all these cartel drug guys who are off balance, knowing that he’s got to figure out, how do I get out of this room without getting killed? And once I walk out, will the timing be right that I could drop to the floor right when the responding FBI agents, again, these are FBI agents from a different [39:08] field office that he perhaps doesn’t have intimate working. knowledge of. I got to trust that these guys got my back and they’re not distracted. So I can’t even imagine having to live with that stress. No, I can’t either. All right. I’ll tell you what, the book, guys, is Empire City Under Siege, the three decades of New York FBI field office man hunts, murders, and mafia wars by Craig McGuire with former retired FBI agent Anthony John Nelson. I pulled as many stories as I could out of the book from him. You’re going to have to get the book to get to the rest of. And believe me, I’m looking at my notes here and the stuff they sent me. And there are a ton of great stories in there, guys. You want to get this book. [39:50] I also want to say there’s something special going on at Wild Blue Press. My publisher specializes in true crime. And it’s just, they’re so nurturing and supportive of writers. Just fantastic facilities and promotions. And they just help us get it right. That’s the most important thing, Anthony, accuracy. So if there’s anything wrong in the book, that’s totally on me. It’s really hard to put one of these together, especially decades removed. But then I’m just thankful for the support of nature of Wild Blue and Anthony and all the remarkable members of law enforcement like yourself, sir. Thank you for your service. And Anthony, and I’m just so inspired. I just have to say, they’re like a different breed. And you folks don’t realize how exciting. Because there are so many stories like Anthony would come up with and he would say, do you think readers would be interested in this story? And I fall out of my chair like, oh my God, this could be a whole chapter. So it was as a true crime fan myself of this material, it’s just, it was a wild ride and I enjoyed it. [40:56] Great. Thanks a lot for coming on the show, Craig. Thanks, Gary. You’re the best.

Join host Melea Hames as she welcomes Donna Castellano, Executive Director of the Historic Huntsville Foundation and steward of the beloved Harrison Brothers Hardware, Alabama's oldest continually operating hardware store. They explore the importance of preservation, the unexpected stories uncovered through historical work, and how Harrison Brothers blends the past with modern-day community connections — making it one of North Alabama's most meaningful places to visit. Follow North Alabama on Social Media! Website Instagram TikTok LinkedIn YouTube Twitter Facebook The Unexpected Adventures in North Alabama Podcast is a part of the Destination Marketing Podcast Network. It is hosted by Melea Hames and produced by Brand Revolt. To learn more about the Destination Marketing Podcast Network and to listen to our other shows, please visit https://thedmpn.com/. If you are interested in becoming a part of the network, please email adam@thebrandrevolt.com.

You jump straight into the deep end with Richie Castellano as you explore what happens when preparation collides with opportunity. You follow his path from mixing weddings to standing behind massive analog rigs, wrangling six guitar channels, chasing down mysterious hums, and learning fast that the gremlins always show up when you least expect them. When the call comes to go from being Blue Oyster Cult’s sub sound engineer to bass player in four days with 21 songs to learn, the lesson is clear: play something you know, rehearse smart, and build a Just In Case bag that saves the gig. Success is not luck. It is preparation meeting the moment, and you are either ready or you are not. In order to Always Be Performing you need to Always Be Preparing! As the conversation deepens, you learn how adaptability gets and keeps gigs, from joining the culture of a band to solving problems so painlessly you become indispensable. Richie breaks down the craft of learning, teaching, and arranging vocal harmonies, including Yes music at the highest level, where not nailing the vocals means the whole thing falls apart. You hear why simplifying is sometimes the smart move, how spreadsheets can ease rehearsals, and why blending matters more than showing off. The episode closes with practical wisdom on collaboration with front of house, constant communication inside the band, and surrounding yourself with people on the same mission. This is a masterclass in being prepared, predictable, drama-free, and trusted when it counts. 00:00:00 Gig Gab 516 – Monday, January 12th, 2026 January 12th: National Hot Tea Day Guest co-host: Richie Castellano NAMM coming up! GG Coverage Sponsor: Ultimate Ears Pro! 00:01:40 From mixing weddings to arenas overnight Called to sub as Blue Oyster Cult's sound engineer Steve “Woody” La Cerra “Make them sound like a big bad rock band” 00:06:53 The differences doing sound in a big room? Six channels of guitar for 3 guitar players! Where's the cowbell?!? 00:10:28 Arriving ten minutes before downbeat with the biggest system of my life And it's analog! What's that low hum 00:12:49 The Gremlins That Run Around On Stage When You're Not Looking Play something you know 00:17:46 SPONSOR: Squarespace. Check out https://www.squarespace.com/GIGGAB to save 10% off your first purchase of a website or domain using code GIGGAB. 00:19:10 From sound to…playing bass in four days! Here's 18 songs… I mean 21 songs. Be ready to play this by Friday Success is when preparation meets opportunity. Here's the opportunity. Now you have to prepare for it! Buck Dharma on Gig Gab First gig was canceled… But that led to a rehearsal Time to talk about the JustInCase…aka the Idiot Bag! Plugged into the TV to rehearse 00:22:39 “If you can do this five times in a row, this will be your gig.” 00:25:02 Do you just want me to join the band? If you solve a problem for someone painlessly, you're not likely to be replaced. Be Prepared and Predictable And No Drama 00:28:41 Joining the culture of a band Matt Beck on guitar for the recent Jon Anderson tour fit perfectly Being adaptable gets and keeps gigs 00:33:22 Learning and teaching harmonies Learning how to soften and blend 40th Anniversary of Agents of Fortune A trick: learn how to do impressions. “Sing this like Peter Gabriel”, “Sing this like Michael McDonald” 00:39:51 Arranging Harmonies for Yes music Don't be afraid to simplify, folks Use a spreadsheet! Get it to “the best WE can do it” Then ask “how can we make this blend better?” 00:45:13 If we don't nail the vocals, we suck! 00:48:29 The collaboration between band and front of house Ask front of house engineer: What do you need from me to sound good? End sound check with an a capella vocal moment 00:52:24 Talk to your bandmates and continually tweak things “Why does your snare drum sound different today?” 00:54:11 Surround yourself with bandmates who are on the same mission 00:59:58 When bands write vocal harmonies 01:04:18 Gig Gab 514 Outtro Follow Richie Castellano Contact Gig Gab! @GigGabPodcast on Instagram feedback@giggabpodcast.com Sign Up for the Gig Gab Mailing List The post Be Prepared and Predictable: How Richie Castellano Stays Gig-Ready — Gig Gab 516 appeared first on Gig Gab.

Nuestro DJ favorito de Barcelona, Phran, nos visitó para hablar sobre la música electrónica en Venezuela, pinchando con Arca, raptor house, changa, minitecas, sus sellos Vimana y ACA y mucho más. (Emitido por primera vez en 2024)

Hace unos días, conocimos que un streamer español de 37 años, Sergio Jiménez, había muerto durante un reto viral. Este consistía en tomar drogas y alcohol a cambio de dinero. Un modelo que, desde hace años, practica Simón Pérez tras su polémico vídeo hablando sobre el precio de las hipotecas en 2017. Lo hablamos Lydia Ramón y con Ángeles Caballero, autor del artículo "La era de la crueldad". Una semana después de la detención de Maduro, analizamos todo lo que ha sucedido en estos siete días con Nicolás Castellano, enviado especial a Cúcuta. Sara Canals, corresponsal de la SER en Washington. Donald Trump ha amenazado de tomar el control de Colombia y también Groenlandia es la segunda isla más grande del mundo y es un territorio bastante desconocido para la mayoría de nosotros. Este viernes se asoma a La Ventana Francesc Bailón, antropólogo especializado en pueblos árticos y viajero polar, para que nos cuente más detalle sobre esta isla. 

Entrevista en Castellano. Pitágoras: el misterio de la voz interior, una investigación de arqueología filosófica con Mario Pérez Ruíz. Mario nos Hablará de su libro y explicará las opiniones científicas y filosóficas del antiguo filósofo griego Pitágoras y sus seguidores, y describe su influencia en científicos, ocultistas y otros, desde Giordano Bruno hasta Einstein y Hitler. Revista digital La tortuga Avui. www.latortugaavui.com ​Xarxès: Facebook grup Secrets del Pirineu, Instagram: area-hermetica-radio. Telegram: [https://t.me/.../FSW-COI...//t.me/joinchat/FSW-COI-ZiUtQ0Aj) Ràdio Caldes 107.8 fm, per TDT per les comarques del Vallès canal 515, Instagram com Àrea Hermètica ràdio i per internet: www.radiocaldes.cat areahermeticaradio@gmail.com

Ben Cardew hablo con DJ Fra, leyenda de la música electrónica en Barcelona y booker de Primavera Sound, sobre la importancia de Underground Resistance, antes de su concierto en Primavera Sound 2026. ¿Quiénes son este misterioso colectivo de Detroit? ¿Por qué son tan importantes para el techno? ¿Cuáles son sus mejores temas? Todo se revelará en un programa tanto para los fans de UR como para quienes los descubren por primera vez.

La figura de Gonzalo de Berceo está relacionada con los poemas y las obras que ha legado desde el siglo XIII. La comarca en la que nos encontramos, en pleno Camino de Santiago, dio lugar a grandes obras de la literatura como el Códice Albeldense del que también hablaremos

Pere Aznar, Marina Lobo y Antonio Castelo analizan la actualidad política de la semana. Además, Laura Del Val, humorista que dejó la abogacía para dedicarse a la comedia, nos cuenta algunas anécdotas de su recorrido profesional. Y por último, el periodista musical Jesús Casañas presenta su libro 'Metálica'  y ofrece una visión sobre el grupo y su obra.CRÉDITOS:Guion: Pere Aznar Producción: Toni Cuart Dirige: Javier del Pino Realización técnica: Emilio Escribano

Pere Aznar, Marina Lobo y Antonio Castelo analizan la actualidad política de la semana. Además, Laura Del Val, humorista que dejó la abogacía para dedicarse a la comedia, nos cuenta algunas anécdotas de su recorrido profesional. Y por último, el periodista musical Jesús Casañas presenta su libro 'Metálica'  y ofrece una visión sobre el grupo y su obra.CRÉDITOS:Guion: Pere Aznar Producción: Toni Cuart Dirige: Javier del Pino Realización técnica: Emilio Escribano

Pere Aznar, Marina Lobo y Antonio Castelo analizan la actualidad política de la semana. Además, Laura Del Val, humorista que dejó la abogacía para dedicarse a la comedia, nos cuenta algunas anécdotas de su recorrido profesional. Y por último, el periodista musical Jesús Casañas presenta su libro 'Metálica'  y ofrece una visión sobre el grupo y su obra.CRÉDITOS:Guion: Pere Aznar Producción: Toni Cuart Dirige: Javier del Pino Realización técnica: Emilio Escribano

Pere Aznar, Marina Lobo y Antonio Castelo analizan la actualidad política de la semana. Además, Laura Del Val, humorista que dejó la abogacía para dedicarse a la comedia, nos cuenta algunas anécdotas de su recorrido profesional. Y por último, el periodista musical Jesús Casañas presenta su libro 'Metálica'  y ofrece una visión sobre el grupo y su obra.CRÉDITOS:Guion: Pere Aznar Producción: Toni Cuart Dirige: Javier del Pino Realización técnica: Emilio Escribano

En esta La Sobremesa recibimos a emprendedores, desarrolladores en la gastronomía que nos compartieron historias personales bien variadas e interesantes.  Recibimos a Eliana Félix y Francisco O'Neill de Figari, y a Nacho Casciani de Café del Atelier Casciani Castellano

Entrevista en Castellano. Tradiciónes, leyendas, historia oculta y lugares donde el Grialrecogió tradición en el Pirineo. El Sabarthés en un lugar donde en su escudo hay un Caliz y sumos custodios de algo que no es material, Un Blason de costumbres ancestrales. Invitado Pablo Benítez Águilar.

Als Castellano am 16.12.1985 erschossen wird, endet die große Zeit der Cosa Nostra in New York. Neue kriminelle Organisationen übernehmen, doch ganz verschwindet die Mafia nicht. Von Almut Finck.

Para celebrar 40 programas en una temporada hoy tenemos la plana completa! Eso viene acompañado de triple análisis: Keeper, Death Stranding 2 y Thank Godness You're Here. Tres grandes títulos para todos los gustos. Hablamos también de la situación de COD, el port de Skyrim para Switch 2 y mucho mas. Comentarios: https://t.me/comentariosindiepodcast

Una de las protagonistas de la tercera entrega de la saga 'Avatar', Oona Chaplin, se asoma a La Ventana para hablar como fue su experiencia trabajando en la película. SIRAT es candidata a mejor película extranjera y banda sonora en los Globos de Oro. Informan nuestros especialistas en cine, Pepa Blanes, jefa de cultura de la SER y José Manuel Romero. Naciones Unidas y distintos informes de ONG han documentado la muerte de, al menos, 157.000 civiles durante la guerra que Al Assad llevó a cabo contra la población que se rebeló contra el régimen durante la primavera árabe. Informa Nicolás Castellano, enviado especial en Al Tayhah, Deraa. 

Argentino y lector (así se auto-describe) Emmanuel Trifilio habla de su experiencia tocando bandoneón, componiendo música y viviendo como inmigrante y artista en Washington, DC. Creadora: Liz Sabatiuk | Música: "De Cayetano" grabado por Trifilio Tango Trio y "El Eco de tu Amor" grabado por QuinTango | Crédito de la foto: Eric Booth Show Notes Lee más sobre Emmanuel en su sitio web. Luego escucha sus composiciones para Trifilio Tango Trío y QuinTango y ve el vídeo donde bailamos yo y Rubén. Conoce el cuento de Julio Cortazar que menciona Emmanuel, "La noche boca arriba." La Casa del Tango en La Plata todavía existe. Para descubrir el Rock Argentino de la niñez de Emmanuel, revisa esta enciclopedia!  Lee la historia de los bandoneones “AA” y mira a Astor Piazzolla tocar su homenaje “Tristezas de un doble A.” Lee más sobre Carlos di Sarli, el compositor y pianista que inspiró el tema “De Cayetano.”  Emmanuel “cita” a un amigo en el episodio; se refiere a Miguel Di Genova de Otros Aires. Ve una transcripción del episodio de Emmanuel aquí.

El Diablo! nunca mejor dicho: Amunhiky nos trae el análisis de este port del mítico action RPG. Hablamos de Valve, desde el impacto negativo que puede tener en un proyecto el salir allí hasta las limitaciones por sus vetos y política de no revisión. Y cómo en este programa están Amunhiky y Chrono todos sabemos que significa: Doom o Half Life. Bueno, algo de eso hay. Comentarios: https://t.me/comentariosindiepodcast

Empezamos el podcast comentando sobre posible precio y rumores de la Steam Deck (si, es el hardware que nos va a tener pesados un tiempo). También reflexionamos sobre los regalos que piden los niños gamers a sus padres: será Pokemon? Mario? GTA? o hay algo mas? También tenemos ya los nominados a los GOTY y conversamos un poco al respecto. Comentarios: https://t.me/comentariosindiepodcast

A l'Al Dia Terres de l'Ebre d'avui divendres, 5 de desembre: - Obrim l'Informatiu amb les nostres emissores per conèixer que està marcant l'actualitat de la jornada al territori. - A l'Entrevista del Dia: amb Joan Gaya, coordinador d’operacions de Kronospan a l’oest d’Europa, analitzem l’evolució de l’empresa que s’implantava al territori el 2023 combinant reindustrialització, sostenibilitat i creació de llocs de treball. - A de Poble en Poble: Mireia Faura parla en Maria José Castellano, regidora de Turisme de l’Ajuntament de l’Ametlla de Mar i Eva Garcia, tècnica de turisme sobre el Mercat de Nadal de l’Ametlla de Mar, que tindrà lloc del 6 al 8 de desembre al Parc del Bon Repòs. - Redacció Oberta: Cel Prieto, Núria Mora i Víctor Montecino Valls ens porten activitats, cinema, sèries i música per gaudir al 100% del cap de setmana.

Programa en Castellano. Invitado el investigador Mario Pérez. La muerte es uno de los mayores misterios de la vida. ¿Morimos realmente o tenemos un alma que vive separada del cuerpo? Muchos están confundidos al respecto, lo que ha generado grandes malentendidos sobre la muerte. ¿Ofrece la Biblia respuestas?. Las religiones ofrecen diversas respuestas, algunas aparentemente creíbles y otras inverosímiles. Sus explicaciones a menudo se contradicen, lo que aumenta la confusión e incertidumbre sobre lo que sucede después de la muerte. Una idea muy común es que las personas nacen con almas inmortales. Muchos creen que después de la muerte, el alma es consciente y se dirige a un lugar o estado literal de dicha o tormento. Otros enseñan que al morir, el alma es absorbida por una "conciencia superior". Algunos esperan reencarnar, regresando a la tierra como otra persona o como un animal. ¿Podemos determinar con exactitud qué es la muerte? ¿Tenemos almas inmortales? ¿Somos conscientes después de morir? ¿Estamos destinados a ir a algún lugar para experimentar algún tipo de recompensa o castigo? ¿Qué sucederá realmente al morir? El relato bíblico de los primeros seres humanos. Dios instruyó personalmente a Adán y Eva, pero ellos decidieron desobedecerlo. Permitieron que Satanás los influenciara para que hicieran su propia voluntad en lugar de obedecer las instrucciones de Dios. Dios les informó que, por haberlo desobedecido, sus vidas se volverían difíciles y, como les había advertido, morirían. «Con el sudor de tu rostro —le dijo Dios a Adán— comerás el pan hasta que vuelvas a la tierra, porque de ella fuiste tomado; pues polvo eres, y al polvo volverás» ( Génesis 3:19 ). El Misterio de la muerte en el Shivaísmo abarca la indagación filosófica sobre la naturaleza y el significado de la muerte. Destaca la muerte como una transición compleja en la existencia, sugiriendo que no debe verse con miedo, sino como un aspecto natural y esencial de la vida. Este tema resuena en varios poetas, quienes exploran la naturaleza enigmática de la muerte, enfatizando su importancia dentro de la experiencia humana más amplia. Redes: Facebook grupo Secrets del Pirineu Telegram: https://t.me/joinchat/FSW-COI-ZiUtQ0Aj Instagram: area_hermetica_radio Ràdio Caldes 107.8 fm, www.radiocaldes.cat y Radio Granollers. areahermeticaradio@gmail.com

La mayoría de la gente compra cosas que no quiere (como un Ferrari) para impresionar a gente que no le importa. Roberto Castellano rompe con ese mito.En esta entrevista sin filtros, Roberto se abre sobre su TDAH, su soledad elegida y cómo sobrevivió a un infarto masivo a los 37 años gracias a una mentalidad estoica inquebrantable. No es solo una charla sobre culturismo; es una clase magistral sobre cómo construir una identidad propia, ignorar el marketing barato y vivir bajo tus propias reglas.

En este episodio, Roberto Castellano —una de las voces más veteranas, respetadas y sin filtros del culturismo español— desmonta, punto por punto, la realidad del culturismo actual. Habla de genética, hábitos, redes sociales, anabolizantes, vieja escuela vs nueva escuela, dopaje en el deporte de élite, nutrición, mentalidad y cómo ha cambiado el deporte en los últimos 25 años. ⌚ Timeline 00:00 — Introducción 01:24 — Qué necesita un culturista de éxito 02:24 — “El gordo dice que come poco…” 04:00 — El mayor error del nuevo culturismo 05:40 — El culturismo ya no es afición, es exposición 07:27 — Quién es Roberto Castellano 11:45 — Buen preparador vs marketing 15:38 — Entrenadores que no se han puesto fuertes 17:57 — El precio real de una preparación 24:15 — Dopaje en distintos deportes 25:05 — “El 99% de los culturistas de competición consume” 27:17 — “Culturismo solo hay uno” 29:43 — Fotos: ¿Natural o no? 35:00 — Cómo detectar si alguien es natural 37:07 — Vieja escuela vs nueva escuela 40:40 — La moda de los carbohidratos 41:25 — Resistencia a la insulina 44:00 — Dietas y exceso calórico 46:40 — Los 3 suplementos clave 48:23 — Su historia con MásMúsculo 50:17 — Proyectos futuros 53:20 — Tier list de ejercicios 01:03:57 — Preguntas rápidas #RobertoCastellano #Culturismo #FitnessEspaña #Bodybuilding #MásMúsculoPodcast #NaturalVsNoNatural #Dopaje #Anabolizantes #OldSchoolVsNewSchool #Culturista #Entrenamiento #NutriciónDeportiva #Mentalidad #Epigenétic

"La voz de Hind" es la película que se basa en la llamada real que Hind Rajab hizo a emergencias el 29 de enero de 2024. Esta niña palestina -de 6 años- iba en coche, con sus tíos y sus primos, y cogió el móvil para comunicarse con su madre, con otros familiares y con emergencias, cuando ella era la única persona con vida a su alrededor. Después de pasar por festivales de cine internacionales, como Venecia o San Sebastián y hacerse allí con la larga ovación y los premios del público, aterriza en cines españoles este viernes 28 de noviembre. Sus actores protagonistas, Saja Kilani y  Motaz Malhees, charlan con Ángels Barceló y Nicolás Castellano sobre la producción y la realidad que hay detrás.  

In this episode of Gangland Wire, retired Kansas City Intelligence Unit detective Gary Jenkins sits down with author Jay Baer to explore the hidden, human side of organized crime's biggest names — Al Capone, Meyer Lansky, John Gotti, and Paul Castellano. Jay's book, Mob Life: The Private World of Capone, Lansky, Gotti, and Castellano, takes a unique look beyond the murders, rackets, and headlines to reveal how these mobsters actually lived — what they ate, how they dressed, their relationships with religion, and how they handled immense power and wealth. Listeners will hear: How Al Capone's family sold his spaghetti sauce recipe to Ragu — their first commercial product. Why Meyer Lansky, the most devout of the four, was denied the right to die in Israel by Prime Minister Golda Meir. The lavish lifestyle and fatal missteps of Paul Castellano, the “Howard Hughes of the Mafia.”   The contrast between Gotti's flamboyance and Lansky's low profile — and how each approach shaped their downfall. The staggering fortunes these men built — and how, in the end, they all lost it. Jay also shares his own lifelong fascination with organized crime, his career outside writing, and his upcoming project, How to Live Like a Gangster — No Prison Required, a look at mob values like loyalty, respect, and power through a modern lens. Gary and Jay swap mob history from New York to Kansas City, including a discussion of the real story behind scenes from Casino and Kansas City's own underworld power struggles. ON AMAZON Wayne said 5.0 out of 5 stars Great Facts on the Mob Reviewed in the United States on October 3, 2021Format: Kindle If your looking for a good fast interesting read on the Mafia, this is the book for you. Full of information on mob types that most have no clue about. You can't lose with this book I believe.

In this episode of Current Account, Clay is joined by Kezia McKeague, Regional Director for Latin America at McLarty Associates and IIF's Martín Castellano, Head of Latin America Research, to unpack the results and implications of Argentina's recent midterm elections. The conversation explores President Javier Milei's strengthened political mandate, the role of U.S. financial support in shaping the electoral outcome, and how markets have responded. Kezia and Martín also discuss the short- and medium-term risks to Milei's economic stabilization plan, including persistent inflation, a widening current account deficit, and pressure on real wages and growth. Finally, the discussion considers whether this moment marks a turning point for reform in Argentina and broader Latin America. This IIF Podcast was hosted by Clay Lowery, Executive Vice President, Research and Policy, with production and research contributions from Christian Klein, Digital Graphics and Production Associate and Miranda Silverman, Senior Program Assistant.

Viajamos a Iguazú, uno de los destinos más espectaculares de Argentina. Te cuento mi experiencia en la triple frontera, las Ruinas de San Ignacio y las Cataratas del Iguazú, y además te enseño 3 frases clave en castellano argentino para tu próximo viaje.En este episodio de Easy Argentine Spanish te llevo a Misiones, al noreste de Argentina, para compartir mi experiencia en Iguazú: desde la triple frontera con Brasil y Paraguay, hasta la emoción de la Garganta del Diablo y la aventura en gomón bajo las cataratas.Además, vas a aprender frases útiles en castellano argentino como  "paseo en gomón" y “quedarse empapado”, que te van a servir si planeás viajar a esta región.

En Capital Intereconomía, la sección Empresas con Identidad ha contado hoy con Beltrán Aznar, CEO de Clevergy, y Paloma Castellano, directora de Wayra España, para conocer los detalles de la nueva ronda de inversión de 3,2 millones de euros que impulsa la expansión internacional y el desarrollo tecnológico de Clevergy, la plataforma SaaS que ayuda a las comercializadoras energéticas a ofrecer a sus clientes herramientas inteligentes para controlar su consumo eléctrico, optimizar el autoconsumo solar y gestionar dispositivos del hogar. Beltrán Aznar ha explicado que la entrada de Wayra, el corporate venture capital de Telefónica, y de fondos como Racine2, Axon Partners Group, Satgana y Angels Capital, refuerza el posicionamiento de Clevergy en el ecosistema energético y tecnológico, aportando no solo capital, sino también una red de alianzas estratégicas que facilitará su crecimiento. “Esta ronda nos permitirá escalar operaciones, perfeccionar nuestros modelos de ahorro energético basados en inteligencia artificial y avanzar en la digitalización y descentralización del sector”, ha destacado Aznar. Por su parte, Paloma Castellano, desde Wayra, ha subrayado que la inversión responde al compromiso de Telefónica con la innovación abierta y sostenible, destacando que Clevergy “encaja perfectamente con la estrategia de Wayra de apostar por startups que combinan tecnología, escalabilidad e impacto real en sectores clave como la energía”. Según Castellano, la conexión con la red global de Telefónica permitirá a Clevergy acelerar su internacionalización y colaborar con grandes corporaciones energéticas. En el bloque Digital Business, hemos conversado con Stella Luna de María, CEO de Pentaquark Consulting, sobre la transformación digital y la gestión inteligente de datos en las empresas. También han participado José de la Vega, CEO de Arktic, y Roberto Carrasco, responsable de negocio internacional de Unicaja, para analizar cómo la banca está modernizando su relación con el tejido pyme y corporate. Carrasco ha señalado que Unicaja “está apostando por sistemas más ágiles de intermediación de divisas y gestión de efectos comerciales” para responder a las nuevas necesidades regulatorias y al desafío de escalar servicios financieros más personalizados y competitivos en el mercado internacional.

En este episodio muy, pero muy especial hablamos acerca de la película Tron Ares. Además revisamos el box office de la semana, comentamos las noticias geekas más relevantes de la semana, hicimos un 10 en 10 de personajes en moto, Iulius nos habló de los comics que ha leído esta semana y nos cuenta un trivia de la semana. Los productores ejecutivos de este episodio son: Rubs30 Ivan de Dios Perez El Compadre Geeko Carlos Alexander Sorto Gonzalez Simon Rodriguez Perez Fernando Bilbao Zabdiel Jaramillo Guiselle Silva Benigno Mandujano Rodrigo García

Support Connection's Annual Support-A-Walk for Breast & Ovarian Cancer is community event dedicated to raising awareness about the needs of those living with breast, ovarian, or any gynecological cancer. The 2025 walk took place on Sunday, October 5, at FDR State Park in Yorktown Heights, NY, where everyone was invited to “Walk With Us, Wherever You Are.” The walk helps fund Support Connection's free and vital services, including one-on-one peer counseling, support groups, educational and wellness programs, and social activities. Participants came together to celebrate, support, and remember loved ones. Families, friends, businesses, and organizations all joined to show compassion and encouragement.  Westchester Talk Radio was there, with host Andrew Castellano speaking with WHUD Radio personality Heather DeLuca to capture the energy and inspiration of the day.

Support Connection's Annual Support-A-Walk for Breast & Ovarian Cancer is community event dedicated to raising awareness about the needs of those living with breast, ovarian, or any gynecological cancer. The 2025 walk took place on Sunday, October 5, at FDR State Park in Yorktown Heights, NY, where everyone was invited to “Walk With Us, Wherever You Are.” The walk helps fund Support Connection's free and vital services, including one-on-one peer counseling, support groups, educational and wellness programs, and social activities. Participants came together to celebrate, support, and remember loved ones. Families, friends, businesses, and organizations all joined to show compassion and encouragement.  Westchester Talk Radio was there, with host Andrew Castellano speaking with Maid Brigade owner Robin Murphy to share stories of community support and inspiration from this meaningful event.

Hello! Today we are going to talk about Spain. Interesting facts and curiosities about this Historic country. I will be reading a text in Spanish very slowly and you will try to understand word by word. You will be learning some interesting facts about Spain and also you will be improving your listening skills in Spanish. I will translate the text in English and then read in Spanish again in a normal speed.My new Podcast for learning Spanish: Cinema VIP in SpanishApple Podcasts:https://podcasts.apple.com/fi/podcast/cinema-vip-in-spanish/id1824447231Spotify:https://open.spotify.com/show/4gd0wYIEpFA6RsBt66DLRr?si=m-QQ-FQUTO6-bUAjnoo-GAYou can support me and my podcast if you want:Donate with PayPal:https://www.paypal.com/paypalme/spanishwithdennisYou can buy me a cup of coffee here:https://www.buymeacoffee.com/spanishwithdennisEspañaEspaña es el tercer país del mundo (tras Italia y China) con más lugares declarados Patrimonio de la Humanidad por la UNESCO. En total hay 47, siendo la Sagrada Familia de Barcelona y la Alhambra de Granada los dos más visitados.  El español no es el único idioma que se habla en España: en sus respectivas comunidades también se hablan otros idiomas cooficiales, como el catalán, el valenciano, el gallego, el aranés y el euskera, además de otros dialectos. El flamenco es uno de los símbolos españoles a nivel internacional y su origen es algo confuso. La teoría más aceptada es que se originó en Andalucía gracias al crisol cultural de gitanos, árabes, judíos y, obvio, andaluces. Es el segundo país con más viñedos de todo el mundo, ahora se entiende que en España el vino nunca falta! Las tapas son un orgullo nacional. Hay varias teorías alrededor del nombre, pero una de las más convincentes cuenta que en sus comienzos consistían en rebanadas de pan o lonchas de embutido que se servían para tapar las bebidas y así no dejar pasar a moscas y bichos. Cadiz es la ciudad habitada más antigua de toda Europa: la tacita de plata fue fundada por los fenicios alrededor del 1.100 a.C. Para los amantes de la literatura, Don Quijote del autor español Miguel de Cervantes, es considerada la primera novela moderna. Puedes visitar la casa de su infancia en Alcalá de Henares. Hoy en día, el país cuenta con el rey Felipe VI, la reina Letiza, y sus dos hijas, Leonor, princesa de Asturias, y la infanta Sofía de España. El Palacio Real está situado en Madrid, y incluso está abierto a visitas. Sin embargo, España es una monarquía constitucional. Esto significa que la realeza no tiene poder absoluto y en su lugar lo ejerce de acuerdo con una constituciónMy new Youtube channel: Spanish with Dennishttps://www.youtube.com/channel/UCQVuRUMQGwtzBIp1YAImQFQMy new Discord server and chat and you can already join and write to me there:https://discord.gg/HWGrnmTmyCMy new Telegram channel and you can already join and write to me or comment there:https://t.me/SpanishwithDennisJoin my Patreon:https://www.patreon.com/spanishwithdennisSupport me by joining my podcasts supporter club on Spreaker:https://www.spreaker.com/podcast/slow-spanish-language--5613080/supportDonate with Boosty:https://boosty.to/spanishwithdennis/donateDonate with Donation Alerts:https://www.donationalerts.com/r/dennisespinosaDonate with Crypto currency:Bitcoin (BTC)1DioiGPAQ6yYbEgcxEFRxWm5hZJcfLG9V6USDT (ERC20)0xeb8f678c0b8d37b639579662bf653be762e60855USDT (TRC20)TXoQwsaiTGBpWVkyeigApLT8xC82rQwRCNEthereum (ETH)0xeb8f678c0b8d37b639579662bf653be762e60855If you have any other suggestions or recommendations on what other platform you can support me and my podcasts, please let me know. You can write to me on telegram.Thanks in advance!! Gracias por adelantado!My other podcasts you can find it on different platforms and apps:1-  Comprehensible Spanish Language Podcast2 - Crazy Stories in Spanish Podcast3 - TPRS Spanish Stories

El retrato de un personaje siniestro y ambicioso, capaz de efectuar el peor trabajo sucio al servicio de las dictaduras más execrables del Siglo XX. También es la crónica de una herencia maldita a través de la mirada crítica de su nieta, Loreto Urraca, que con dignidad y humildad repudia.

Algunos artistas flamencos de Castilla La Mancha nos ofrecen hoy su arte. En el comienzo José Gálvez y Mayte Martín y a continuación escuchamos a artistas de la provincia de Ciudad Real como Gregorio Moya, Oscar Herrero, Ricardo del Moral, José Almarcha o Enriquito. De otra provincia cercana llega el cante de María Toledo o Israel Fernández.Escuchar audio

Iñigo Markinez y Nicolás Castellano nos cuentan los detalles del amistoso entre Euskadi y Palestina que se jugará en San Mamés el próximo 15 de noviembre. Por último, entrevista al extremo español Suso, futbolista del Cádiz.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's commitment to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Meghan Hennessy, member of The Uke Sisters and The Block Island Musicians, about the island's vibrant music scene, local traditions, and more.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's dedication to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Steve Felipe, owner of Ballard's, about local favorites, island life, and more.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's dedication to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Stephen Papa, co-owner of Aldo's Restaurant, about the restaurant's rich history, mouthwatering offerings, and what keeps locals and visitors coming back year after year.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's dedication to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Michael Mederios, a longtime Block Island taxi driver, about island life, local favorites, and more.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and quintessential New England charm, the island offers plenty to explore, but one local favorite stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves classic baked goods in a warm and friendly atmosphere. Today, Aldo's dedication to fresh, homemade offerings goes beyond breads, pastries, and ice cream. You'll also find healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And of course, no visit is complete without Del's Lemonade or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Aldo's co-owner, Aldo Leone, for a conversation about the bakery's enduring tradition, tasty offerings, and why locals and visitors alike keep coming back.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's commitment to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Aldo's Restaurant co-owner Christina Papa about the restaurant's long-standing traditions, mouthwatering offerings, and why Aldo's continues to be a beloved Block Island destination for locals and visitors alike.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and classic New England charm, the island offers plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves timeless baked goods in a warm and welcoming atmosphere. Aldo's dedication to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And no visit is complete without Del's Lemonade, something from Aldo's pastry boat, bringing the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with Aldo's Bakery co-owner Bobby Leone about the bakery's traditions, delicious offerings, and why it continues to be a Block Island favorite.

Back in August, while on vacation, Westchester talk radio host Andrew Castellano visited one of his favorite destinations: Block Island. Known for its natural beauty and quintessential New England charm, the island has plenty to explore, but one local favorite truly stands out: Aldo's Bakery. A Block Island tradition since 1970, Aldo's serves classic baked goods in a warm and welcoming atmosphere. Today, Aldo's commitment to fresh, homemade offerings goes beyond breads, pastries, and ice cream. Visitors can also enjoy healthier options like açai bowls, fresh fruit smoothies, avocado toast, and other nutritious treats. And of course, no visit is complete without Del's Lemonade, or something from Aldo's pastry boat, which brings the bakery experience right to your own boat (listen for the Andiamo!). Tune in as Andrew Castellano speaks with his kids, Andrew and Danna, for a lively conversation about Block Island, Aldo's Bakery, and family memories that make this destination so special.

La Cadena SER ha desplazado a sus principales enviados especiales a Jerusalén para seguir informando sobre la evolución del conflicto en Gaza. Àngels Barceló, Nicolás Castellano, Pablo Morán y Fernando Bayo se encuentran esta mañana en la Ciudad Vieja, concretamente en la Explanada de las mezquitas, uno de los puntos más simbólicos y tensos de Oriente Medio. Además, Pedro Sánchez asegura que hay jueces que están haciendo política y que no cumplen la ley. El presidente del Gobierno se refirió así en Televisión Española a las causas abiertas contra su mujer y su hermano. Sánchez afirmó que estos jueces, que son una minoría, hacen mucho daño a la Justicia.

The free Robison Summer Concert Series at Kensico Dam Plaza in Valhalla lit up the night on July 18th, 2025 with a powerhouse performance by The Jersey Tenors. Known as the newest Opera/Rock mash-up sensation, the group delivered an explosive blend of iconic opera classics alongside rock legends like Queen, Elton John, and Bon Jovi. Staying true to their roots, they also celebrated New Jersey's finest, paying tribute to Frankie Valli and The Four Seasons, Frank Sinatra, Bruce Springsteen, Kool and The Gang, and Whitney Houston. Westchester Talk Radio host Andrew Castellano spoke with group member Brian Noonan, adding a personal touch to an unforgettable summer evening. 

Learn Spanish Past Tenses Step by Step! In this lesson, we'll review the three most important past tenses in Spanish: Pretérito Indefinido (completed past actions) Pretérito Imperfecto (habits and descriptions in the past) Pretérito Perfecto (recent past, experiences) Perfect for A1–A2 learners who want to understand when and how to use each tense. Includes examples, vocabulary, and practice exercises so you can speak about your past clearly and with confidence. Whether you're listening on the go or watching with your notebook, this class will help you make sense of Spanish past tenses once and for all! Join the Live Spanish Zoom Class!• $20 per class• Small group lessons focused on speaking, listening, and reading• Ideal for A1–A2 learners who want to improve quickly in a fun, supportive environment Book a FREE consultation session:https://calendly.com/davidalexandercantu Follow me for more Spanish learning content:YouTube: https://www.youtube.com/channel/UCl-umo0w-yVjyfYz5zUcRvgInstagram: https://www.instagram.com/davidalexandercantu/TikTok: https://www.tiktok.com/@davidalexanderspanishFacebook: https://www.facebook.com/davidalexandercantu/LinkedIn: https://www.linkedin.com/in/davidalexandercantu/

In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy.   References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15   Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

El obispo gerundense Enric Pèlach explica en un libro, a sus 88 años, recuerdos de su tarea pastoral en los Andes peruanos.