Podcasts about GIK

Lukas Rimbach (SAE Frankfurt) ist heute bei uns in der Show zu Gast. Er ist Manager of Customerservice and Sales bei GIK Acoustics Europe und schon seit mehr als 9 Jahren bei GIK tätig. GIK ist einer der renommiertesten Hersteller von Akustikmodulen aus UK und mittlerweile weltweit tätig. Angefangen hat Lukas allerdings mit einem eigenen Tonstudio und kam erst später über Umwege zu seiner Position. Hört rein! LinkedIn: https://www.linkedin.com/in/lukas-rimbach-60b0659b/ Life After SAE auf Instagram: https://www.instagram.com/lifeaftersae/ Mehr zu Kurt gibt's hier: https://www.instagram.com/kurt_jonathan_engert/ Mehr zu Glen gibt's hier: https://glenschaele.com/linktree

Vi dykker ned i Sundhedsstrukturkommissionens anbefalinger. Det sker sammen med Sidsel Vinge, som er medlem af kommissionen og Mads Koch Hansen, tidligere formand for Lægeforeningen. De fortæller, hvilken model de foretrækker, og hvor man kan skære kommunenernes sundheds- og ældreopgaver over i to, hvis det bliver nødvendigt.Det taler vi om:Slog Sophie Løhde forvaltningsmodel 1 og 2 ihjel på pressemødet?Hvor lille en del af kommunernes opgaver kan man nøjes med at flytte til nye omsorgsregioner?PLO tog smilende imod anbefalinger, selvom de ifølge Sidsel Vinge er et brud på deres monopol. Hvorfor?Denne model tror gæsterne mest på kan blive til noget.Hvorfor gik kommissionen gik uden om forebyggelsen?Gik man for let hen over det specialiserede handicapområdet?Hvorfor centralisere digitaliseringen med alle de statslige it-skandaler i baghovedet?Vært: Ole Toft, sundhedspolitisk analytiker på Altinget Gæster: Sidsel Vinge, medlem af Sundhedsstrukturkommissionen, og Mads Koch Hansen, tidligere formand for LægeforeningenProducer: Clara Vestergaard Lausen, podcastassistent Hosted on Acast. See acast.com/privacy for more information.

I dagens episode runder Anders, Amalie, Nikolaj og Nanna første semifinale i Malmø. Hvad var godt, hvad var dårligt, Hvordan var værterne og scenen. Gik de rigtige videre? Alt kan du høre i dette afsnit Følg "@eurovisionfanklub" på instagram for ekstra content og find vores spotify -liste for at høre episoden omtalte sange

I nat taler vi om vores navne. Er du tilfreds med dit? Har du skiftet det ud? Hvorfor? Og efter hvilke kriterier udvalgte du et nyt? Gik du til numerolog for at få hjælp? Hvorfor valgte dine forældre at give dig netop det navn, du bærer? Og hvilke overvejelser havde du, da du skulle finde det helt rigtige navn til dine egne unger?See omnystudio.com/listener for privacy information.

I nat taler vi om vores navne. Er du tilfreds med dit? Har du skiftet det ud? Hvorfor? Og efter hvilke kriterier udvalgte du et nyt? Gik du til numerolog for at få hjælp? Hvorfor valgte dine forældre at give dig netop det navn, du bærer? Og hvilke overvejelser havde du, da du skulle finde det helt rigtige navn til dine egne unger?See omnystudio.com/listener for privacy information.

I nat taler vi om vores navne. Er du tilfreds med dit? Har du skiftet det ud? Hvorfor? Og efter hvilke kriterier udvalgte du et nyt? Gik du til numerolog for at få hjælp? Hvorfor valgte dine forældre at give dig netop det navn, du bærer? Og hvilke overvejelser havde du, da du skulle finde det helt rigtige navn til dine egne unger? See omnystudio.com/listener for privacy information.

Välkommen till HATTRICK LIVE! -Podcasten för dig som hejar och spelar i Sirius Innebandy! På fredagen den 26 Januari spelade IK Sirius IBK mot Gävle GIK där Sirius vann med 13-9. I denna match fick jag intervjua Sirius-spelaren, Kasper Broby som gjorde 6 poäng i denna match. Han berättar att det var en tuff match där Sirius gör 4-0 på 6 minuter och det var en utmaning som Sirius har aldrig testat förut. Sedan vad Kasper berättar mer om matchen och hur Sirius ska spela mot Visby IBK i helgen. Detta får du veta när du lyssnar på Hattrick Live 08 med Kasper Broby! Nu när du lyssnar på HATTRICK LIVE, så söker du på “HATTRICK LIVE”, där poddar finns och så gör du likadant på Spotify och Apple Podcaster. Sedan tycke du på “FÖLJ” eller “PRENUMERERA” då får du dom senaste avsnitten av HATTRICK LIVE! Nu finns även Hattrick Live på Google Podcast och Acast. Test/Podd: Sebastian Wolff Foto: Eva Ohlström.

"Om kort tid bliver en drøm til virkelighed. Efter flere end 44 bitre år med adskillelse, vil Tyskland, vores fædreland, igen være forenet. For mig er dette øjeblik et af de lykkeligste i mit liv". Sådan faldt ordene fra Helmut Kohl om aftenen den 2. oktober 1990. Dagen efter var Kohl ikke længere kun kansler i det demokratiske Vesttyskland, men i hele det genforenede Tyskland. Det kommunistiske Østtyskland var officielt ophørt med at eksistere. De følgende år bød på en hård omvæltning for de 17 millioner borgere, der var rundet af DDR-systemet. Mange mistede deres jobs og endnu flere deres identitet. Gik genforeningen for hurtigt? Hvad var det for en selvforståelse østtyskerne fik frataget? Og hvorfor raser debatten igen i Tyskland om forskellen i historiesynet hos øst- og vesttyskere? Det er nogle af spørgsmålene i denne uges Kampen om historien, hvor Adam Holm taler med Moritz Schramm, der er lektor i tyske studier og opvokset i Vest-Berlin, og med kunstneren Heike Arndt, der er født i det daværende DDR, men flygtede til Danmark i 1985. Musik: Adi Zukanovic.

Grækenland (Den Hellenske Republik) kaldes Europas vugge og det har som bekendt sin rod i Antikken med de græske filosoffer og hele den demokratiske og politiske indflydelse. Derudover er den omfattende mytologi, deres teater tradition og den store betydning for den olympiske sport også en faktor helt op til moderne tid. Endelig skal de mange begreber, ord og fænomener tages med og jo netop oftest udspringer af alt det forrige. Sejrstimen hylder den græske forbindelse i dagens tema ved at spille sange der alle har en titel i en relateret kategori, delt op i enten mytologi, lokation, historie eller begreb. Uden dog at selve teksten nødvendigvis handler om det titlen kunne indikere. Alphaville, Abba, Anti/Beyond, Böbe, Dead Can Dance, Echo & The Bunnymen, Ganger, Ozark Henry, IAMJJ, Keane, Lonely Robot, Marina, Moi Caprice, Peter Murphy, Roisin Murphy, Rufus Wainwright, Julia Wolf, Patrick Wolf og The Wombats udgør dagens program. Men derudover er der også lidt meta-græsk i form af to navne fra selve landet, der begge har en særlig historie med den største græske helt i moderne musik: Vangelis. Den ene er naturligvis Demis Roussos og den anden er den store karakter skuespillerinde Papas, der også sang og i øvrigt blev 94 (Gik bort 4 mdr. efter Vangelis i 22).

This blogpost has been updated since original release to add more links and references.The ChatGPT Plugins announcement today could be viewed as the launch of ChatGPT's “App Store”, a moment as significant as when Apple opened its App Store for the iPhone in 2008 or when Facebook let developers loose on its Open Graph in 2010. With a dozen lines of simple JSON and a mostly-english prompt to help ChatGPT understand what the plugin does, developers will be able to add extensions to ChatGPT to get information and trigger actions in the real world. OpenAI itself launched with some killer first party plugins for: * Browsing the web, * writing AND executing Python code (in an effortlessly multimodal way), * retrieving embedded documents from external datastores,* as well as 11 launch partner plugins from Expedia to Milo to Zapier.My recap thread was well received:But the thing that broke my brain was that ChatGPT's Python Interpreter plugin can run nontrivial code - users can upload video files and ask ChatGPT to edit it, meaning it now has gone beyond mere chat to offer a substantial compute platform with storage, memory and file upload/download. I immediately started my first AI Twitter Space to process this historical moment with Alessio and friends of the pod live. OpenAI's Logan (see Episode 1 from *last month*…) suggested that you might be able to link ChatGPT up with Zapier triggers to do arbitrary tasks! and then Flo Crivello, who just launched his AI Assistant startup Lindy, joined us to discuss the builder perspective.Tune in on this EMERGENCY EPISODE of Latent Space to hear developers ask and debate all the issues spilling out from the ChatGPT Plugins launch - and let us know in the comments if you want more/have further questions!SPECIAL NOTE: I was caught up in the hype and was far more negative on Replit than I initially intended as I tried to figure out this new ChatGPT programming paradigm. I regret this. Replit is extremely innovative and well positioned to help you develop and host ChatGPT plugins, and of course Amjad is already on top of it:Mea culpa.Timestamps* [00:00:38] First Reactions to ChatGPT Plugins* [00:07:53] Q&A: Keeping up with AI* [00:10:39] Q&A: ChatGPT Intepreter changes Programming* [00:12:27] Q&A: ChatGPT for Education* [00:15:21] Q&A: GPT4 Sketch to Website Demo* [00:16:32] Q&A: AI Competition and Human Jobs* [00:18:44] ChatGPT Plugins as App Store* [00:34:40] Google vs ChatGPT* [00:36:04] Nader Dabit on Selling His GPT App* [00:43:16] Q&A: ChatGPT Waitlist and Voice* [00:45:26] LangChain with Human in the Loop* [00:46:58] Google vs Microsoft vs Apple* [00:51:43] ChatGPT Plugin Ideas* [00:53:49] Not an app store?* [00:55:24] LangChain and the Future of AI* [01:00:48] Q&A: ChatGPT Bots and Cronjobs* [01:04:43] Logan Joins Us!* [01:07:14] Q&A: Plugins Rollout* [01:08:26] Q&A: Plugins Discovery* [01:10:00] Q&A: OpenAI vs BingChat* [01:11:03] Q&A: App Store Monetization* [01:14:45] Q&A: ChatGPT Plugins API* [01:17:17] Q&A: Python Interpreter* [01:19:58] The History of App Stores and Marketplaces* [01:22:40] LindyAI's Flo Crivello Joins Us* [01:29:42] AI Safety* [01:31:07] Multimodal GPT4* [01:32:10] Designing AI-safe APIs* [01:34:39] Flo's Closing CommentsTranscript[00:00:00] Hello and welcome to the Latent Space Emergency episode. This is our first ever where chatty PT just dropped a plugin ecosystem today, or at least they demoed their plugins. It's still on the wait list, but it is the app store moment for ai. And we did an emergency two hour space with Logan from OpenAI and Flo Coveo from Lin AI and a bunch of our friends.[00:00:28] And if you ever wanted to listen to what it's like to hear developers process in real time when a new launch happens, this is it. Enjoy,[00:00:38] First Reactions to ChatGPT Plugins[00:00:38] I assume everyone has read the blog post. For me the, the big s**t was do you see Greg Brockman's tweet about FFMPEG? I did not. I should check it out. It is amazing. Okay, so. So ChatGPT can generate Python code. We knew this, this is not new, and they can now run the code that it generates.[00:00:58] This is not new. I mean this is like, this is good. It's not like surprising. It's, it's fine. It can run FFMPEG code. You can upload a file, ask it to edit the video file, and it can process the video file and then it can give you the link to download the video file. So it's a general purpose compute platform.[00:01:22] Wow. Did they show how to do this? Agents? I just, I just, I just pinned it. I just, it did I, did I turn into this space? I dunno how to use it. Yeah, it's, it's showing up there. Okay. It can run like is. Is, is, is my And by, by the way hi to people. I, I don't know how to run spaces. I, I not something I normally do.[00:01:42] But You wanna say something? Please request. But yeah, reactions have a look at this video because it run, it generates and runs video editing code. You can upload any arbitrary file. It seems to have good enough compute and memory and file storage. This is not chat anymore, man. I don't know what the hell this is.[00:02:01] What, what is this?[00:02:02] Well, progress has been all faster than I expected. . That's all I can, I, I, I don't know how to respond. . Yeah. It's pretty wild. I wonder, I wonder, I'm wondering how, how this will affect, like opening up the app store different from, let's say Apple App Store when it opened up. Because there are a lot of, of big companies just building stuff already and how like a small developer will be able to, to build something that's not already there.[00:02:31] I dunno. It will be interesting. So one thing that's really nice, have you seen the installation process for the plugins? It's right at the bottom of the blog post and you have to play the video to kind of see it, but literally anybody can write your own plugin. It's a small little json file. It's, it's literally like 10 lines of code.[00:02:49] It's 10 nights of, you described what your plugin does in English, you given an open API spec. That's it. That, that's, that's the plugin. It's amazing. You can distribute your plugin. This is, this is, this is easier than extensions manifest v3, which nobody knows how to use. This is English.[00:03:15] You write English . So, so, yeah. I mean I think, I think I think there'll be a lot of people trying to develop for this if they can get access, which you know, everybody's on a wait list. I, I've, I've signed up to 200 wait lists this week. . I wonder if, if it'll be different if you, if you sign up as a, as a developer or as the chat user.[00:03:35] Hopefully it doesn't matter, right? Use different emails and sign up to both. Let's, let's just see, in fact, use t to generate like, plausible sounding reasons for why you want to build whatever. Cause they don.[00:03:47] But yeah, I mean, how do you compete? I, I don't know, man. You know, it, it's really OpenAI is definitely a partnership strategy to do what they do here which means they're essentially picking favorites. So if you're a competitor of Expedia Kayak Open Table Wolf from Zapier, you're a s**t out of luck, kind of, you know?[00:04:06] Cause these are presumptive winners of their spaces. Right. And it'll happen in too many industries, probably. Right. I was thinking about maybe summarization or, or I don't know, YouTube video summarization, but there seems to be some application of that already on the examples that you shared. Yeah, yeah, yeah.[00:04:26] They have shared that, but I think there's always room to improve the experience. It's just, you know It's interesting which platform, like sort of platform strategy, right? Like if you write an OpenAI chat plugin, you instantly gain access to a hundred million users, right? All of them can instantly use your thing.[00:04:47] Whereas if you are a standalone app or company, good luck trying to able to use OpenAI through you. There's just no point. So you much rather just be on OpenAI platform and promote there. The the fortunate thing is they don't have some kind of like popularity ranking yet. Actually, someone should go open, someone should do register, like OpenAI plugins list.com or something where like everyone can like submit their own opening app plugins and like upload them, review them cuz this like, this is not a complete app store without reviews and a rating system and a reputation system and probably monetization opening app probably doesn't care about that.[00:05:26] But I mean, I can go start that right now. F**k. I can go start it right now.[00:05:34] Yeah, it'll, it'll take a while, right? Like this is the, like the basic version of the, of the app evolving. But this is a pretty basic version. Yeah. The basic version can browse the web, it can write, write an execute code. It can retrieve you know, we can retrieve data from documents, right? So all the documents search just died.[00:06:02] There's like five of these in Y Combinator right now. Oh.[00:06:08] Examples. Pretty crazy how, how they use the FFMPEG library or, I dunno if I'm saying that correctly, but right in there. You don't need to, to write code to,[00:06:27] it's crazy. Dunno. Yeah. Any reactions? Please, please, you know, open space. Anyone can request a speaker. Oh, Ash, come on in. Ash. I have to add you a speaker. Yeah, we're, we're just reacting here. I just, I, I needed a place to talk and I'm in Japan and I don't have anyone else to talk to, so I need, I, I I just want to share this moment.[00:06:46] I think it's a special moment in history. This is the biggest new app source since ever. Yeah. Hey, Shawn. I think plugin is already taken. . Oh man. Someone, someone bought it already. Yep. , of course. Right? Of course. , what are your reactions? What how are you feeling? What's what are you seeing out there?[00:07:07] Just crowdsource all the tweeting. Yeah, man, it's, it's been wild. I mean, I get out of there to like five minutes and then anything drops, you know, , I think productivity today will be like zero. If I, if I still, like, I quit my job you know, a few weeks ago but I would not be working today. There, there's no point.[00:07:26] There's nothing else. There's nothing else that's important, like, nothing's going on. Like this is the only story. Yep. . I wonder if you have any, any frameworks or anyone that's listening any frameworks on, on how you're handling all of this new, new stuff. Like every single day if something new comes up and, or you can like get the, the wait list invitations to, to use the new products.[00:07:52] Q&A: Keeping up with AI[00:07:52] Like, for example, today I just got the, the one from GIK cli and I was just playing around with that. And then suddenly I started to see all of the, these Twitter threads with announcements. It's getting crazy just to follow up with, with the stuff. And every day something new comes up and started. I was starting to feel a lot of formal, you know, like, h how do you keep up with all of these?[00:08:12] Or how do you focus? Does anyone have any, any good frameworks for that? Well, feel free to respond. Also, we, we have some more room if anyone wants to share your feelings. This is a, this is a safe space to share your feelings because. We all dunno how to react right now. I don't know. I just, I, I, I have a few notifications on for OpenAI employees and people that I do that I think do good recaps.[00:08:37] So in other words, find the people who are high signal and who do a lot of gathering of other people's stuff for, and then just subscribe to those people and trust that that is 90% of it and forget the 10%[00:08:57] Alright. And Sean probably, I have, I have another question. So I can't really figure out like what's left for us to do, you know, without AI tools. Like what, what is we learn next? You know, there's no learning some coding stuff, because you can only do that. You know, we can't do arts, we can't do poetry.[00:09:17] Farming[00:09:17] bakery, probably making things with your hands. Enjoying the sun.[00:09:23] Do you guys think this should be regulated? Like you don't go more than like the speed is going? I don't know. I dunno. There's, there's no point. Like if, like, if you regulate OpenAI, then someone else will come along. The secret is out now that you can't do this, and at most you'll slow things down by 10 years.[00:09:44] You called the secret. This is the end. . Yeah. Yeah. I, I don't know. Secret is out. China's trying to do it right, so I don't know if people have seen, but like China was, was fairly strict on crypto, which is probably good for them. And now they're, they're also trying to clamp down on AI stuff, which is funny because oa like they're, you know, the m i t of of China Ihu, I was actually doing like producing like really good bilingual models.[00:10:10] But yeah, they, they seem to be locking this down, so we'll see. We'll see. Right? Like you know, in, in, in sort of the, the free world there, there's open innovation that may be unsafe. OpenAI, try to be safe. You know, there, there's a big part of the blog post that was talk, talking about red team meeting and all that.[00:10:24] I'm sure every one of us skipped it. I skipped it. And then and then we just care about capabilities and now that, you know, every time people have their minds opened, like, I did not know Ron. EG in chat.[00:10:38] Q&A: ChatGPT Intepreter changes Programming[00:10:38] Now that I know my conception of what a REPL is, or literate programming or what a notebook is, is completely blown outta the water, right?[00:10:44] Like there's no like this, this is a new form factor for me. So not now that I know that I won't be innovating on that or trying to, to shape this into something that I can use because I want to use this, and this is, this is clearly better. Does, does this ha have to do with, with the, like AI as backend?[00:11:00] Yeah. Ideas that have been, yeah. You know, GP as backend. So, so apparently I had a few friends reach out to those guys and they're not doing that because it's not mature enough. Like it works for a simple demo. So, so for, for those who don't know ScaleAI did a hackathon I think two months ago just before I did mine.[00:11:18] And the winner on the hackathon was, was something called GPT is all you need for backend. And they actually what in register? DBC is backend.com. But as far as I can tell, they're not gonna start a company based on that because if you even push a little bit, it falls apart, right? So GPT3 wasn't good enough for that.[00:11:36] Maybe GPT4 is maybe GPT5, but then it'll still be super slow and super expensive. Like you don't want to run, you know, a large language model on every API request. So I don't know. I think it'll be good for scaffolding. I think it'll be good for re type use cases. Like, Hey, I need to edit this video on an ad hoc basis.[00:11:53] I don't, I don't want to learn FFMPEG. I don't need to now, because I can just talk to ChatGPT. That makes sense. But if you want a reliable, scalable backend you probably don't want to use it on a large language model, but that's okay because language model can probably help you write it rather than run it.[00:12:13] Hey, Lessio. Hey guys. Oh yeah. Hey guys. What's up? Hey, yeah, we're, we're just, there's no structure. Just drop your reactions. Let's go. Awesome. Awesome, awesome guys.[00:12:26] Q&A: ChatGPT for Education[00:12:26] What do you think what if Shawn, what do you think if you could use you know AI and the education field, like, you know, like personal attribution system for students?[00:12:35] What's the thought automation education or attribution edu edu education. Yeah. That is the holy grail. This is called the Blooms two Sigma problem. Like the, the, the, one of the big issues of education is we have to teach to the slowest person in the class. And, and, you know, I'm a beneficiary of, of a gifted education system where they take out you know, nominally high IQ people and put them in a separate class.[00:12:56] And, and yeah, we did, we did do better. What if we can personalize every student's experience there's, there's some educational theory. This is called Bloom's two Sigma problem. Where the results will be better. I think that we are closer, but like, I still hope that we're pretty far , which sounds like a negative, like why do I want to deny education to students?[00:13:18] Because if we are there, then we will have achieved theory of mind for ai. The AI has a very good model, is able to develop a representation of who you are, is able to develop theories that the test who you are in, in a short amount of time. And I, it's a very dangerous path to, to go down. So I want, I want us to go slowly rather than fast on, on the education front.[00:13:41] Does that make sense? Yeah, definitely. It makes a lot sense and yeah, definitely. I think personally the education for each student and making it turn the best way would be great. And what do you think how about like, first of all, I'm, I'm having very curious, curious question, you know, like we are having, this week was full of launches, so how you guys are keeping up with if we're not, this is, I created the space though cuz I cannot handle it.[00:14:05] Today, today was my breaking point. I was like I don't know what's happening anymore. Yeah, like every single day I'm just in constant anxiety that like everything I assumed about the world is gonna be thrown up. Like I don't know how to handle it. This is a therapy session, so feel free to express.[00:14:21] Definitely. It's, it's been a very overwhelming feeling for everyone of us like that. I think, you know, like past two weeks and like the industry was definitely a lot, lot of ones we are definitely open for, you know, to discuss more about it. Thanks a lot for this space. Sean. Yeah. Appreciate. Yeah. Va one more thing.[00:14:39] So I think that the most constrained version of education use cases is language teaching. So there are a few language teachers out there speak I think is one of them that is an OpenAI partner. And they're also part of the chat GPT plugin release. , but there are also other language tutor platforms.[00:14:57] You can certainly have your news. There was one that was released maybe like four or five months ago that you can try to see what the experience is like. And you can, you can tell when the teacher has no idea who you are and it breaks the illusion that you're speaking to another human. So I, I just, you can experience that today and, and decipher yourself if we're ready for that.[00:15:14] I hope that we're not ready and it seems like we're not ready. Yeah, definitely, definitely. Thanks a lot for sharing. And guys, what do you think?[00:15:19] Q&A: GPT4 Sketch to Website Demo[00:15:19] Like I, in the launch of four we have show that we could, you know, generate apps and web apps just from you know, like a single simple sketch, you know different tent.[00:15:30] Just start from sketch. So what do you think like how, how it would be impacting the industry? It's all because it's not just like that, that sketch was very, was a very shitty sketch. Right. It was just like drawn on a piece of paper. But if you combine that with the multimodal, like it was that they had another part of that demo where they had a screenshot of the discord the opening eye discord and you're mm-hmm.[00:15:57] and they put it in and it, it like read the entire screen to you and if you can read the entire screen, you can code the entire . Screen. So it's over like[00:16:12] It's definitely, I think interaction, interaction designers, you know, like people who like, think design function still have some time. Yeah. I, I just, I just, I just tried the same thing, you know on bar today and it was like much more better than GPT3 so definitely it's you know, things are really changing.[00:16:30] Q&A: AI Competition and Human Jobs[00:16:30] Great forward. I'm, I'm really worried what we wanna do, you know? Do you think the competition will like stable everything? Like what competition? Anthropic. Well, like Google, Google won't race, I don't think. Google Race, like Google the fight. The one that, the one that launched the W links list of blog posts.[00:16:50] That, that Google.[00:16:55] Well, no, not, not the list. Not the list. Competitions will come. . I have a question. I mean I mean my fear is many of the jobs that are going away, whether it is developer and designers, because I mean, I think GPT four is very capable. So how to deal with it. I mean, it's going to replace, I mean, many of the jobs, that's for sure.[00:17:16] Yeah. It's okay. We'll find new jobs or we'll, we'll not need jobs anymore. We should, we should also, Start universal basic income. That's, that, that is something I, I do believe, yeah, I think the, the main change is going from the web of like, syntax to like the web of Symantec. So if your job is valuable because, you know, a unique syntax or like, you know, how to transform things from like words to syntax, I think that will be a lot less useful going forward.[00:17:45] But the Symantec piece is still important. So a lot of product work, it's not just writing CSS and HTML and like the backend for it. It's a lot more than that. So I just thinking about how do you change your skills to do that. But yeah, even the sketch, you know, you gotta like, you gotta draw the sketch and to draw the sketch, you gotta know where the button should go.[00:18:06] You know, you have, you know, incorrect with it. Yeah. I'm just processing this as I, I just read the whole thing as well. And Yeah, I mean, it's been a wild wild couple of weeks and it's gotten me thinking that maybe all our role was over the past couple years was we were just middlemen to talk to computers, right?[00:18:27] So we're sitting in between, it's over man PMs or business folks or whoever wanna build a product. And then as a software developer, you're just a middle manish talking to the machine and it seems like. N LP is the way forward and, oh, yeah. Yeah. It's, it's been it's been, it's been a while.[00:18:42] ChatGPT Plugins as App Store[00:18:42] Couple of weeks. It's, I feel like we all just have to move either move upstream or, or find other jobs. You just gotta move upstream, either toward product directly. Cuz right now the plugin is yeah, is, is just you know, it's still a very sanitized UI that is controlled by OpenAI. But imagine them opening up the ui portion as well.[00:19:03] So you no longer need to have a siloed product that needs to integrate. ChatGPT instead you can bring your product directly into into ChatGPT, I don't think exactly. I think that would be probably the next next logical move after this, and I'm sure they're already thinking about that.[00:19:22] So that's a great, I don't know if this is, it's wild. What are you guys think? Yeah. Yeah. Like, so before you came up, right, I was, I was talking about this like ChatGPT has at least a hundred million users. Why would you bring people to your platform rather than write a plugin for ChatGPT and use their platform?[00:19:39] It's an open question now. Zapier just launched their integration. OpenAI and OpenAI just launched their integration of Zapier. Which one is gonna be more interesting? Probably OpenAI.[00:19:50] Totally a hundred percent . this is the app store of wow, our century of our decade. Like, I don't know, maybe century. I, I think the thing with ster though, if you think about it, like how many native apps do you download every week, every month versus like how many web things you use. So I think it's all about whether or not long-term opening eyes incentivize to keep broadening the things you can do within the plugin space.[00:20:17] And I think the lab, you know, as this technology gets more widespread, they're gonna have a lot more pressure from regulators, safety, blah, blah, blah. So I'm really curious to see you know, all, all the, all the government stuff that they'll, they'll have a congressional on this in six months and by then it will be completely irrelevant.[00:20:34] It's like that beside that time, they, they, they called it the GameStop guy after he made like 20 million on GameStop. And he just, you know, he was like, yeah, you know, followed the rules, made a bunch of money for those who don't know, unless you're our co-host. On the, we were supposed to drop an episode today, which I was supposed to work on, and then Chatty Phi dropped this thing, and now I, I can't think about anything else.[00:20:59] So this, this is my excuse for not, for for not working on the podcast today. . I know it's funny, we have like three, four recorded ones and spend last week, like GP four came out and we're like, okay, everybody's talking about this is irrelevant. What else? Anything else? Like, but I'm really excited about the, I, I feel like the first, the first use case for this, and I think he tweeted it about it too, is like, before if you had to do like data reformatting and stuff like that, it was really hard to do programmatically.[00:21:32] You know, like you didn't have an natural language interface and now you have it. And before if you had to integrate things together, like you could explain it very easily, but you couldn't like, put the APIs together and now they kind of remove all that part. So I'm excited to see what this looks like.[00:21:48] For commercial use cases, you know, you could see like, is there gonna be like a collaborative ChatGPT where like you're gonna have two, three people in the same conversation working on things. I think there's a lot of ui things that will improve. And so as we have lining from OpenAI for a second, almost pulled them up, but I'm sure you cannot talk about it[00:22:07] But yeah, it'll be interesting to see. Yes, sir. We're extremely excited. Extremely excited. I, I don't, if you, I don't know what else I'm, I'm like, so as far as I can tell there's the, there's hacker and Twitter. I haven't looked at Reddit yet, but I'm sure there's a bunch of reactions on Reddit.[00:22:23] I'm sure there's the OpenAI discord that we can also check out. I got locked out of the discord at some point, but yeah, anyone, anyone else like see news, demos, tweets the whole point of this is that it's live, so please feel free to share on comments or anything like that. But yeah. Yeah, the, the craziest thing I saw was the Mitchell from Hash.[00:22:44] We tweeted about Yes. How the integrations actually work and you just write a open APIs back and then just use natural language to describe what it's supposed to do. And then their model does everything. I wonder if they're using the off-the-shelf model or they have like a fine tune model to actually run integrations.[00:23:02] I wonder, I don't think they'll ever say it. Knowing them, probably they would just use the base one cuz they want, like, I think opening eyes kind of wants a God model, right? There's no point. It's not intellectually interesting to do small models, but like, like it's trivial. Yeah. Yeah. It's, this is a minor optimization problem as far as the, the long arc of history and the, the point is to build a gi safe agi and I, I do think this is kind of safe, right?[00:23:33] Like, . One of the criticisms that people were saying on hacks was that this is very closed. Like it's, it is an app store. At any point opening, I can randomly decide to close this like they did for Codex, and then they change their minds. Whereas if you use something like Alan Chain, it is more open and something that at the same time, like clearly this is a better integration path than long-chain.[00:23:56] Like, I much rather write this kind of plugin than a long-chain plugin. So they, they've managed to, I mean, they know how to ship man, like they're an AI research lab, but they also know how to ship product. Mm-hmm. . Yeah. I, I'm curious to see what the pricing models gonna look like. Also, I mean, if I'm writing the plugin, this is great because I don't even have to take care of the compute, you know, like, I just plug it in, then they actually run everything for me.[00:24:26] Yeah, but how, how it'll be monetized. I mean if the is giving their plugin know Expedia, I mean, people will not go to their website. Yeah. I don't, I mean, yeah. I have no idea that they, I don't think they said also don't super care . Yeah. It's because in the, in the app store, it's transaction driven.[00:24:46] But on Channel G, you're just paying a flat fee every month. So like, you can't really do revenue share on a flat fee. And I don't think that we use like, the Spotify model, but it's like a why not the amount of times? No, wait, wait, wait, wait, wait. Why not , you have Spotify. I just, Spotify model works. Cause swyx has power, right?[00:25:05] Opening has power. Same thing. They have all the audience. Yeah. But every, every every song is like the same value. Like if you listen to song actor to song y. , like, you're gonna make the same money. Like if I'm calling the API to, for like the meme generator or if I'm calling the API for the, you know, business summary thing, they're probably gonna cost the firm things, you know, so it's kind of hard to model up for OpenAI to say, Hey, okay, we're charging, we're going from 20 to 35 bucks a month.[00:25:36] But then like, how do you actually do royalties on a per model basis? Like how do people decide what royalties to negotiate? This probably needs to be a flat fee, but I dunno. Or put your credit card it OpenAI and then every time you wanna use a plugin, you pay for it separately. Uvp, usage based pricing all the way, and then you just get at the end of every month.[00:25:58] Exactly the, the only question mark is like, how much does OpenAI value the training they on and like how much they wanna subsidize the usage. Canada they have, they have promised to not use any of our usage data for training. So, oh, but the, I think like the plugins, it's a, it's a different thing.[00:26:16] It's like, like how you could, you could easily see how are like requests usually structure for like these things, you know, like, are people searching? So how are people searching for flights and stuff like that. I don't know. I haven't read the terms for like the actual plugin, you know, so. Well if anyone has please come up to speak cuz we're all processing this live.[00:26:37] This is the therapy session. Yeah, go ahead. One thing I see is basically you have to change the plugin I mean, to ask anything or even if you did browsing, right? I mean I see. I mean, they are becoming directly competitor to Microsoft also, I think, because now a user can actually just see, I mean, instead of being chat or Google, I mean they, they just.[00:27:04] Basically select the browsing plugin and basically get all the updated data. And other thing I see is basically you have to change the plugins. Like if you want to use the Expedia data, I don't know how it'll fit with the browsing plugin or you can select multiple plugins. But yeah, it is interesting.[00:27:23] I mean, if we get access, yeah, there is no actual browsing plugin. The browsing is a new model. So just like you can select GT three, GT 3 45, GT four, there's a new model now that says browsing alpha. So you, you can use CHATT in browsing mode and then you can use it in plugins mode, which which is a different model again.[00:27:45] So the, the plug browsing don't cross over.[00:27:51] Oh, that's interesting. And how do you see, I mean, in this whole descending, they are becoming competitive to Microsoft or how they're playing it out. I mean, Bing is just by the way, like, yeah, this, this killed the bing wait list. Cuz you don't need to wait for Bing. You can just use the browser mode open of Chatt.[00:28:11] How does it compete? It competes for sure. I don't think Microsoft cares. I don't think OpenAI cares. This is one of those things where like, you know, they are the two, two friends, you know, and they're clearly winning, so who cares? I don't like, I don't imagine it takes any of their mental bandwidth at all.[00:28:29] Yeah. The main thing is Google is Yeah, the main, like how is Google competing? Well let's see. Right. Bard is out there. I haven't got us yet, but could be interesting. Again, like it doesn't seem like they have the shipping capacity or velocity of Open I Microsoft and. That is probably going to bite them eventually because there's already been a big brain drain.[00:28:53] Something like four researchers, four, the top Google Brain researchers left Google Brain for OpenAI in January. And you know, those are the ones that I know about. And I, I imagine there's, there's quite a bit of brain, brain drain and firing going on at Google, so who knows.[00:29:08] All right, well, any other topics, concerns? Hyperventilation, if you just wanna scream I can turn down the volume and you can just, ah, for like five minutes. , that was literally, I was like, I, I need to like scream and just, ah, because what is going on?[00:29:29] I said that I'm filling out the form right now for the Oh, yeah. Okay. So wait list. So use use chat t to fill out that form. Right. And then, and then use a fake, use a different email and fill out the form a different way. This maximizes . I'm going to ask GT for what plugin do I want to build or, right, right.[00:29:51] Exactly. Yeah. Yeah. I, we can brainstorm. My plugins can live. Yeah. I think that will be a fun exercise. Like the, the main thing that breaks my brain is just this, this whole ability to run code, right? Like this is a new notebook, a new ripple. Mm-hmm. It, it looks like it has storage and it has memory.[00:30:08] Probably it has GPUs. That, I mean, can we run Lama inside GP?[00:30:19] I don't know if that's a, a model within a model. I think for me, most of the things come to like, you know, if I have my own personal assistant, what I want the assistant to do. I think like travel is like the first thing that comes to mind. Like, if I could use pt Yeah. Expedia, plug in with my calendar.[00:30:39] Yeah, yeah, yeah, yeah. But it needs to like know where I, where I'm supposed to be going to, you know, like if I just add a calendar that's like I'm going to, you know, room this week. Yeah. And then like can automatically both send my calendar and say, okay, these are like, or like the times that you like to travel, I know that you don't like ops and yada yada, yada.[00:31:00] That's one thing that I've always, we had this thesis at my peers firm about personalized consumer. There's so many website like, . I go to a lot of basketball games and every time I open Ticketmaster or whatever, it always shows me that she's a seat. And like, I'm not gonna see, that's not what I, that's not the tickets I wanna buy, you know?[00:31:18] But doesn't matter how many tickets I buy, never remembers that. So I think a way to say, to see, take all the information in and suggest, Hey, I saw that there's actually a price drop for the specific seats that you want, not for like any seats. You know, I think that would be a, a very good use case. So I've been a personal entertainment assistant for like, travel like going to shows, going to games.[00:31:41] That would be cool. That's what I'll submit on the wait list. Then we'll see if anybody cares. Right. Did you see get Lindy? Yeah. Yeah. At the, maybe you wanna recap, get Lindy for people. I'm gonna pin it up on the. . Yeah. So basically and this is like the kind of like a assistant lend the ai, right?[00:32:03] Yeah. Lend the ai it's on the board right now. Yeah. For those who can see it through the space. Yeah. Yeah. Actually at the AI Thinkers meet up the, the other day, you can basically like create all kind of like personal workflows and you, it kind of looks like integrations like zier, but it's actually just natural language.[00:32:24] So you can pop this thing up on your desktop and say, trying to hire 10 software engineers. So go on LinkedIn and plan 10 software engineers. The next step, draft a, an email that says, I'm the CEO of this company and I'm trying to hire for my team. If you wanna talk. Then the next step is like, send emails to all these people and it's gonna use people data labs or something else that they use on the backend to get the emails.[00:32:50] Then it actually sends the emails and. This is just gonna run in the background as if it was like you actually doing it. It's pretty neat that you don't have to write the actual integrations. Like it just uses natural language so you're not bound by what they build. Like theoretically anything you wanna integrate with, you can just explain to it how it works and it's gonna figure out how to do it.[00:33:12] So there's a wait list now. Flow didn't give us any papers just because we were at the meetup, so I'm also waiting to get access to it, but it looks really, really good. Yeah, so generative AI's top use case is generating wait lists, right? Like we we're, we are, so we have never had such an easy way to generate a lot of wait lists.[00:33:30] A lot of signup for witness. Oh my God. So much interest. So much product market fit. But also you know, one thing that you, you raising this point? I think, I think, I think by the way, I also pin this up. Mindy can support complex roles like no meetings on Fridays, all one-on-ones on Monday. , I like my meetings back to back within five minutes.[00:33:47] Five minutes in between. So it's just arbitrary rules that you could not program in a normal assistant type environment without a large language model. Which is kind of exactly what you want when you're booking your travel, right? Like, hey, I only like aisle seats unless it's it's a flight that is less than one hour that I don't care, right?[00:34:02] Mm-hmm. . So stuff like that I think is, is super interesting. And but also like not a common use case. Like how many times do you travel a year? Like, you know, five, right? Like more than that, but yes, I think for, yeah, a lot of times it's not a, it's not like a super widespread thing, especially if you don't do it or work.[00:34:21] If it's infrequent, you want high value and then if it's, if it's frequents, you can do low value, right? Like that, that's the sort of binary tradeoff, like the Uber is sort of frequent and low value. Airbnb is high value in frequent there's something of that nature. . So like, you want, you want sort of inspections of that sort.[00:34:37] Google vs ChatGPT[00:34:37] But the other thing that you brought to my attention was, and, and has room for Google to do something is do you notice that OpenAI plugins, none of them are Google because they're not friends. So Open BT will probably never have first party access to Google Calendar, probably never your Gmail and probably whatever, you know, Google copies, OpenAI again.[00:35:04] They will do, Hey, we have all your docs.[00:35:10] Yeah, I, I, I'm interested in that because I don't know if you remember, but like in the first iPhone, like YouTube came, like pre-installed on the homepage and then I forgot when, but one of the early ioss, they removed it. So now obviously Google's not a friend. Who's gonna be a friend in the future, who's not gonna be like, do we all have to hail our AI overlords?[00:35:33] Yeah. To get access to the, the only plugin system. Yeah. The only winners are brown CEOs. Think you're fine. Alright. But yeah, yeah. I just invited nada. C my old boss. Hi. You can't lurk. I, I want, I want to hear from you. And but, but also, you know, yeah, I, I think the Google point is actually novel.[00:35:50] I'll probably write something about that. Yeah. I mean, I'll have to write something about this today. So please feed me things to write.[00:36:01] Nader Dabit on Selling His GPT App[00:36:01] Oh, there we go. Hey, what's up man? What are you think. I know it's like, not entirely your space, but like you're, you're all about the future, right? I mean I did build and sell an AI company about a month ago, . I did the wait, what travel app was built on GP T three Tweeted about You sold it? Yeah.[00:36:21] It was getting like a hundred thousand visitors a day, like 60 to 80,000 unique a day. And then I, whoa. Yeah, I sold it like within about 24 hours. I tweeted out that it was for sale. I had like 30 or 40 people in my inbox. Whoa, whoa, whoa, whoa. Okay. I need, so like, but you're right. This isn't my, my man like domain of expertise.[00:36:41] It's fine. You make, you may just a thousand dollars on the side. It's, it's cool. Wait, wait. So I saw you tweet your original thing, which was, Hey you know, GP three can plan your travel. I don't know what happened since then. Can you, can you fill the rest of. Yeah. Yeah. So I mean I was basically, you know, I travel a lot for work.[00:36:55] I, I do travel like once a month and, you know, but I'm also very resource constrained on my time. So I usually like to spend like one day sightseeing. So what I typically do is I go a trip advisor and then I kind of like, you know, Google around and like look at all these things and it usually takes me about an hour to figure out like what I wanna do on my day or two off to go, like sighting.[00:37:14] And then I realized GPT3, you know, you can just literally ask and, and say, okay, within X number of. Like, I'm gonna be in this city, I want to have an iter itinerary. You know, you can give all these different parameters and it gives back a really good response. This was before GPT, even three and a half or four was out.[00:37:30] So I just built like a nice UI on top. Then, like I mapped over the results and, and was linking to, you know, the the Google searches for these different items and, and kind of made it into a nice user interface and, you know, just built it out and tweeted it out. And it, it just got a lot of traction and attention.[00:37:48] Like I said, I had around a hundred thousand visitors a day, like right off the bat, 60,000 uniques like per day. So it was getting a shitload of of traction and. I don't have a lot of free time to kind of like, maintain or build something like that out. So it was costing me money, but I wasn't monetizing it.[00:38:06] So the way that I was thinking to monetize it would be to use affiliate links and stuff like that. So I could either, you know, spend time figuring out a way to monetize it or just try to make, flip it and just make some money. So I decided to sell it and that was kind of it. I just sent a tweet out and kind of said, this is for sale, who wants it?[00:38:25] And I had I had so much inbound from that that I had to delete the tweet within about two hours cuz I was just unable to keep up with all the people that were coming in. And I filled it out a couple of offers and I, I found the person with the most money that could close within the shortest amount of time and just took it.[00:38:44] Well done. Well done. Nice. Awesome. I need a, I need a, I need an applause button right here. . Okay. So with that context your thoughts on today, what you seeing? There's Expedia there, but. Comment on travel or not travel, whatever you want. . Yeah, I'm still reading up on the, the chat plugins actually.[00:39:01] And I was hoping to kind of chime into this to learn a little more about how they work. I'm here on the the page. I've had API access from fairly early on. I signed up and I've been you using it a lot. I'm trying to find some different ways to integrate AI and machine learning into the blockchain space.[00:39:20] There's a lot of stuff around civil resistance that I think are gonna be, you know, pretty interesting use cases for us. It's obviously not like a, a a type of use case that is gonna be useful to, to the general public maybe, but yeah, I'm still, actually still trying to understand how these plugins work.[00:39:35] So what have you seen the developer documentation, which developer documentation at the bottom? Yes. That's where I'm, I'm check, I'm reading through as of now, I see the examples, which are pretty cool. Yeah. Yeah. So my, my quote the, the quote I put on Hacker News was, this is OpenAI leveraging chat, GPT to write OpenAI op open API to extend OpenAI chat.[00:39:58] GPT. I'm confused, but it sounds sick, but yeah, I mean, so open api, you know, not to be confused is OpenAI is randomly the perfect spec for OpenAI to navigate because it, you know, is somewhat plain English. And then you just supply a description for model. You described a off method. So they actually provided a link to a repo where you can see some examples.[00:40:20] The examples are not very, not very flesh out. But you can do, like, bear off, I assume you can do whatever, whatever kind of off you like then you just provide like logo url, legal info url. It's not, it's not, it's not that much. This is 10 times better than Chrome manifest.[00:40:37] Like manifest v3. Yeah, I mean, I'm reading through some of these examples and a lot of them are in Python. I wish they would've more JavaScript stuff, but I would say 10 times would be kind of an understatement if I'm understanding how some of this stuff is gonna work. English is all you need, man.[00:40:53] English is all you need.[00:40:57] Well, so, so, and then I think in buried in the video is sort of the Ethan experience, right? Which is where you specify. So if you're, if you're first party congrats, you know, you're, you're inside of the the chatt ui, but if you're third party, you can just host your Js o file anywhere. It's literally a JSON file on an API spec, right?[00:41:15] You hosted Jason file anywhere. And then you just like plug it into their their, their text field here and then they, they validate a little bit and it's installed. So there is a third party app store on day one. Yeah, that open table plugin example is pretty sick. Yeah. So like yeah, I I What would you want as a developer that's missing?[00:41:41] I think that we're like in the golden age of of being a developer and I don't know if it's gonna go downhill quickly or if it's gonna go like, get better quickly or this is like the, the end of all of it. like, is OpenAI just gonna be where like we do everything like nothing else is like gonna exist.[00:42:00] I think that Okay. You know what I, I know that's not the answer for sure. I'm just kind of joking, but I think it will, this is obviously shut down a lot of companies. This is the app store moment, right? For like, just like, I mean, you and I remember the iPhone app store moment. Some people dropped everything to write apps and they made it big and some, a lot of people did not.[00:42:20] But the people who were earlier rather than later probably benefited from understanding the platform. Like imagine, imagine you, like, you know, you, you are a big React native person for a long while. Like imagine if you had the chance to drop everything and be one of the first developers on a new app store.[00:42:35] Like that's pretty huge. Yeah, a hundred percent. But I'm wondering like the, the type of mode that you'll be able to build with some of this stuff, because it seems like that OpenAI AI will just continue adding more and more features directly into the platform. But I think like for very like, Proprietary type of stuff.[00:42:54] It might make more sense, but like if you, if you want to build like an app for the general public it just seems like they'll end up integrating something like directly within their platform for a lot of different ideas like, such as this travel app that I sold. I have a feeling like they'll have a way better version of that built directly into their platform sometime soon.[00:43:13] Q&A: ChatGPT Waitlist and Voice[00:43:13] Hey, hey guys. Can I ask just to get a quick update does anyone here have access to it yet? Like is it, is it open? Cause I signed up for the wait list, but I haven't seen anything yet. Yeah, no, it's just, it's just wait list where just like 90% of the stuff that people launch, you know, she has a few, she has a few videos and demos, but yeah, it's just a wait list.[00:43:31] Who knows? I mean, thanks. Opening OpenAI Pretty has been pretty good about getting people off wait list, right? Like a lot of people got off the GT four API wait list, like the day after they launched. Mm-hmm. . This one, I feel like they're quite fully baked, like it's. I wouldn't be surprised if they started dropping tomorrow.[00:43:50] So we'll see. But like you can start developing your, your third party plugins today, because there's examples. The docs are like two paragraphs, but that's all I need really . So, so I've been, I've been working and, and I've been following a lot of projects where people are, the one thing I don't see with ChatGPT is like, why are they have, we have Whisper, we have the APIs for ChatGPT.[00:44:13] It's like, why are we not at the point where we're talking to this thing and it's talking back to us? Like, I don't know how we haven't, nobody's wrapped their head around that yet, but it's like, it seems to me like, don't you wanna be like, Hey computer build me an app that does X and it says okay and builds it for you and talks back to you.[00:44:29] Like, I just, it's like, I don't know. That'll be the first probably plugin that I try to work on, but it's just driving me a little nuts. That's all interesting. I like the voice interfaces because sometimes it gets really long, like some of the prompts get really long. They're like, I don't wanna talk that long.[00:44:46] Yeah, yeah. Yeah. I was so, so I was doing, I was messing with the system prompt, basically get it to be like, Hey look, I'm gonna be talking to you. So keep it condensed. I think like the ideal interface would be like, for like, talking to, it would be like putting that at like the system level, but also, you know, being able to type as well as speak to it is just something that I'm, I'm trying to work on.[00:45:08] And I think with Plug, you know, if we could do that with plugins, I'd be huge. Cuz I know there's already a, like a Chrome extension that allows you to talk to it. Or, or I guess you could do it natively as well, but, you know, native stuff on like iPhone and Android is not too good.[00:45:24] LangChain with Human in the Loop[00:45:24] Hey, you, you mentioned that. Hi, by the way. You mentioned the hey way of, of talking to or having way the AI talking to you as a user. So just today there was a new release to of LangChain. I know it's kind of, not really the plugin, but this is the closest thing probably. And they edit a Ask Human tool.[00:45:46] So now the model can ask you a question if it's not sure. About something[00:45:55] to share. Share what? Go ahead. So, so the ask you if it's during its chain of thought, when it's not sure. To an example. Right, right. Oh, I would love that. Yeah. Probably not gonna do that. It's too confident. Yeah, I, I've seen a little bit about. LangChain, but I haven't used it yet. Has anyone here it?[00:46:15] Oh, it's all about it.[00:46:19] I did, I did. I built the LangChain on UI too. It's pretty nice. I mean, especially when it first came out, the, the trolling, it was like so rudimentary. But it's nice to be able to change things together. I think the agent part is pretty interesting. I haven't used it myself because I didn't need it.[00:46:34] But yeah, there's a, a very big community. See, see, light chain was very smart, right? Like they picked out the open source angle first, and then the others like dust or did the closed source angle. Now they have indirect competition with ChatGPT, but Langchain still has that. It's open source, extensible, like you own your agent.[00:46:55] Google vs Microsoft vs Apple[00:46:55] Them doing business deals with OpenAI in, in closed doors, right? Like, so pretty smart, like strategic position. All things considered.[00:47:05] It's a little, isn't it? It's like a little funny to me. That, you know, it's like goo because Google just came out with Bard, right. And I don't know if you guys have messed with Bard at all, but it's at least to me another wait list. Oh, okay. Yeah. I mean, to me it was a little underwhelming. I mean, I'm, I don't know if you've seen like the same, yeah, if you've seen like the screenshots going around, like it seems like, you know, someone tweeted it was like in, in guys in a boardroom or whoever's in a boardroom just being like, s**t.[00:47:30] Like, we need to you know, we lost our first mover advantage here. But it's just kind of funny to me that like, I guess now Microsoft's gonna have like an app store, right? Like just after everything, you know, Microsoft dominated in the nineties and stuff, and then it was Apple, apple, apple. But it's just kind of funny to me that it's gonna be, I guess Microsoft now, right?[00:47:49] Bard feels like Bing does to Google. Totally. Yeah. A hundred percent. I agree with you a hundred percent. All the turntables, right?[00:47:57] Yeah. So for, for those of you who might have missed the earlier discussion the one thing that OpenAI or Microsoft will not do is integrate with your Google calendar. So, the one saving grace that Google probably has it, it probably owns your workspace, right? Like most of us have Google accounts, Gmail accounts.[00:48:14] When we work, we log into Gmail and Google, again, use Google Docs spreadsheets. So if Bard is smart, they will take advantage of that. And then slowly watch as everyone moves to Microsoft Office.[00:48:31] I think Apple should do a partnership with the OpenAI and basically Microsoft. Cause Google has huge advantage of Android. So basically having OpenAI on the, I, I mean, it would I mean having the partnership with OpenAI would make, I mean, very useful on I devices if they, I mean, Siri is really bad and if they integrate with I, I mean they've win the world I think.[00:49:00] So it would be huge, beneficial to Apple and basically the Microsoft also if they integrate together because Microsoft doesn't have any of the devices and most people, I, most ordinary people use the devices iPhone or phone and . So it would be huge advantage. And for the 10, basically Apple I, I'm very curious to see what Apple ships next.[00:49:24] You know, everyone's shipping AI stuff and then Apple was like, Hey, look at our AR glasses. . Yeah, but I mean, ar ar with, with the, with the 3D models that are, that are coming out cuz isn't it mid journeys working on like a three, like their lab, I know is, is building a 3d generative model. And I think that sort of stuff with, with AR is very, oh, is that, is that public?[00:49:45] How did, how did you know that? I don't know if it's public. I, I saw a tweet about it I don't know, like a week ago. It is a semi, semi open secret in San Francisco, but I, I don't know if it's public. Yeah, I think I, I saw them, it was some context of they were talking about text to video and they were like, well we're, we're doing our like 3D modeling first.[00:50:02] So, I mean, my assumption is, and I, I don't work in the space yet, unless anyone's hiring please, I'm looking for work. But it seems to me like Apple. Seems to have their head on straight and like it might be that if they're gonna release these ar like mixed reality ar vr glasses, like, you know, the mo the thing that makes the most sense to me is like getting with generative AI graffiti modeling.[00:50:24] It's like, you know, it would be cool to go to like a coffee house or a bar. And then, you know, when you see like the graffiti in the bathroom when people write sometimes funny stuff, sometimes, like the worst stuff you've ever read in your life and you're like, what is going on when this person's going to the bathroom where they have this much hate?[00:50:38] But it's like, it would be cool to have a component of that, you know, like in the metaverse, so to speak, right? Like, so you put on your AR glasses and it's like, oh cool, I can see like a bulletin board here that exists in the fizzled. But it's also in the, you know, it's like augmented, right? That's just, to me it seems to be like the logical next step.[00:50:57] Interesting. Well, we'll, we'll see that when that happens. I recently got a Quest Pro quest to my, and yeah, my parents love it. And any tech, any type that my parents like, I think has a real crossover appeal. You know, the thing that you, your conversation had gimme an idea for winners of every app store in the early days, like Facebook has an app store, apple had an app store, you know, the winners of an app, store games like what we need Yep.[00:51:24] Is a multi-player. Like everyone logging into chat, BT and then playing a multiplayer game line. Mpc. MPCs are gonna text you on your. , that would be kind of cool.[00:51:40] ChatGPT Plugin Ideas[00:51:40] Actually. I was thinking, I don't, I don't know if it's gonna be game games at first though. Like, it seems like games always push the envelope with tech.[00:51:47] Well, it's like pornography and games, right? But like, I don't know, I was talking to like, you, you mentioned your parents and like you know, I was talking to my mom about this stuff and I was like, you know, I'm seeing stuff that are just demos of just like, Hey, take a picture of your fridge and it'll tell you like, here's what you can make.[00:52:01] Or you know, even like talking to it and just being like, Hey, here's what I ate today. You know, what's my, how many calories I ate today? Or, you know, what's my diet plan? Just things like that. And that's why I brought up the talking to it just with na using natural language and then having it, being able to talk back to you.[00:52:17] I'm surpri I'm like really surprised that they haven't implemented that yet. Cuz it seems to me like that's a use case that a lot of people would use it for, you know? Or if you could just like, you know, call it on a phone if you built like a Twilio back in, into it or something. Like I just don't, it, it boggles my mind why they haven't.[00:52:35] Put that feature in yet? . Yeah. Yeah. I really don't think it's gonna be too long before you're, you're sitting there at work and you get a text or call on your phone from an nbc, Hey, our village is burning down. You need to come over here and help . Do, do you guys think there's gonna be different silos?[00:52:55] Like you know, with Bard coming out and you know, people implementing GP T three and four now, I guess, into all their apps, but do you think they'll be like, chat GP p chat, GP, PT will have their store and then Google will have their store? Do you think it'll be like, there's gonna be a clear Victor here and then, you know, it'll be like, okay, Google's apps or, you know, Google Docs or whatever is like part of chat GP t's plugins, right.[00:53:20] Yeah, it is gonna be like crypto. Everybody's just gonna be fighting for the top. You're gonna have the couple of dominant people, but then you're gonna have all the, the small guys who go up and down and Yeah, I I, I feel like it's gonna be pretty similar to, to how crypto was. So we're gonna have some slur juices is what you're telling me.[00:53:41] Yeah, boy. Nice, nice. I dig it.[00:53:46] Not an app store?[00:53:46] So may maybe we aren't, tell me what you guys think about this, cuz maybe we aren't thinking about this right? Because maybe this is not an app store. Cuz typically in an app store you'll go ahead and choose which plugins you want installed, like on a phone or whatever have you.[00:54:02] But the path forward seems like all the plugins are like omnipresent. I, I don't know why Google isn't shitting their, shitting their pants right now. Cuz basically you check like openly I could just force all. The big companies to write plugins and then just be a single search box for everything. So imagine if you wanna like fly somewhere or you wanna book a hotel you, we have the Expedia and booking.com.[00:54:29] Both of those plugins summoned up and it shows you both the results. And then you can click through on whichever ones you want. And then, yeah, you charge 'em based on click throughs. Like I, I think like we're, maybe we're just getting tripped over by the fact that you have to choose a plugin right now and only interact with that single plugin.[00:54:49] But I think I think the smart move forward would probably be just to have all of them omnipresent and then have this like n l p higher layer up there to summon the right plugin when need be. What, what do you guys think about that? Yeah, so, so that's like the LangChain thing. That's what I haven't used LangChain yet, but it sounds like that's, from what I was reading with LangChain, it sounds like that's kind of is how I thought that worked.[00:55:12] But I don't know, can someone here like enlighten me? I, I don't know if it, how, how LangChain works.[00:55:21] LangChain and the Future of AI[00:55:21] Yeah. I don't know how LangChain works either, but I think it's gonna be a two-way street. Everybody's gonna be making plug-ins with chat GP p t and everybody's gonna be making chat GP plug-ins for other services as well. I think there's gonna be a whole bunch of people about to make a bunch of Jira plugins and stuff like that, so I think it's kind of gonna be a, a two-way street.[00:55:45] I dunno, is anyone else, like, this is super exciting to me. I haven't been this excited about like, the internet since like, probably like the, like the web 1.0 days. Like I, I, I hate, I'm so . Yeah. Like, I hate web two. Like, this is cool. I'm glad that like spaces exist, but I hate Web 2.0, like Web 3.0. I'm about, and like, I, I consider this part of Web 3.0.[00:56:04] But it's exciting, right? Like, this is cool. Like I, I'm really, you know, I'm stoked about, about the progress that's being, like, the joke is like, you know, every day in, in AI is like, it's like way longer, right? It's like we're telescoping very quickly. Yeah, I mean, one of the things, telescope and updating.[00:56:23] Yeah. You know, I, I would say I noticed towards, maybe like three years ago when I was working at aws, it just seemed like for, for about five or or so years, everything was very stagnant and there just wasn't a lot of exciting things that were happening. Everyone was like, if you remember, all the Devrel advocates were like all creating like tutorials around creating your own CMS and your blog, and you saw like that exact same tutorial given by like hundreds of people over the course of a few years because there just wasn't any cool s**t that was happening.[00:56:52] And then I think when crypto and, and blockchain stuff like that kind of caught my attention. Caught my attention, and I'm still excited by that, that stuff. And then this seems to be just almost like when, if you were like around when the iPhone was coming out and actually realized how important it was, I think everyone now is, is seeing this and they're all like realizing how important it is.[00:57:13] And it's cool to be like part of this moment as a software engineer. Yeah, I'm, yeah, go ahead. Oh, sorry. I was gonna say, like, I'm, I'm excited for you, I'm sure you guys saw the alpaca stuff, right? And I know that they're doing D D M C A stuff, but essentially someone's gonna train one of these models and it's gonna, you know, you're gonna be able to run this stuff offline.[00:57:35] And just like the way to, if, if you have access to like I forget which one of the EAC accelerate people was talking about it, but it was like wharf in the flask. It's like you've gotten the machine offline. So if you don't need internet access to access, like, the entirety of human knowledge, whatever's in the data set up until 2021 or whatever, and you don't need internet access, like that's gonna revolutionize everything.[00:57:57] Like, that's insane to think about[00:57:59] Yeah. Oh, well we won't speculating You can run in Inside Chat runs Python. Oh, really? Is that, is that happening? I mean, it has a file system and it has file storage and CPU at memory. Yeah.[00:58:20] is turtles all the way down. Turtles all the way down, man.[00:58:23] The, I, I think the plugin system, if people can get to run their own models like the LAMA ones and the same structure for plugins, you can see like going back to the Metaverse thing like a and snow crash where people built their own like demons. You know, it's like I got the demonn that like kicks people out of the club, the, the black sun.[00:58:43] But you can see in real life it's like I have a bunch of plugins that only I have, you know, and I use them to make myself more productive, use them to make myself, you know, look like I'm working when I'm not working and I'm like responding to my emails and stuff like that. But I think like, The OpenAI releasing this today makes it so much easier to start it because you don't have to worry about any of the infrastructure.[00:59:07] You just build the plugin and then they run everything and you get the best model possible. But I think none line, you know, I would love to walk around with my own, you know, raspberry pie or whatever of my wrist, kind of like I'm fall out and say, Hey, I wanna do this, I wanna do that. I don't know, I don't think we're that far away, so I'm excited to, to keep building.[00:59:28] Shoot, the, the technology exists where you could make that now, but it'd be a little awkward to have

This episode starts from Mūkūrweinī wa Nyagathanga right down to the daughters of Gikūyū and Mūmbi. The characteristics of the clans and how we get to know the clans we belong to. The post S6 Episode 1: Kihumo Kia Mugikuyu first appeared on Shagz Chronicles.

Hvad kommer der til at stå i arbejdsmarkedets historiebøger, når kapitlet om 2022 skal skrives? I dette særafsnit af Fagbevægelse Uden Filter kigger vi tilbage på højde- og lavpunkterne på et særdeles spændende år i dansk fagbevægelse - og et kort blik i krystalkuglen for 2023. Værter: Kristoffer Nordskov og Gitte Redder Producer: Sarah Falsing

Join your host Gow'roD son of Gowron for the ultimate Klingon challenge! This is the blood revenge edition as our first Gik'tal was decided by a single honour point! The Battle of the Dave's continues! Glory shall be won for someone's house!

(00:00) “Der er mulighed for en ny guldalder for kulturen.” Dét sagde statsminister Mette Frederiksen, da Ane Halsboe-Jørgensen overtog posten som kulturminister. Men mener kulturbranchen, at der har været tale om en “guldalder”? Vi spørger Dansk Live og Dansk Teater, hvad de synes om regeringens kulturpolitik.(32:09) Vi har gravet efter guld i vores egne gemmer og fundet et helt særligt indslag frem. For 17 år siden bragte Jyllands-Posten 12 tegninger, der ændrede alt. I anledning af årsdagen for Muhammed-tegningerne havde vi d. 29 september besøg af tre af de tegnere, der dengang gik mere under radaren, mens hele verden rasede over Kurt Westergaards tegning af Muhammed med en bombe i sin turban. Gik deres bidrag og budskab tabt i alt postyret? Gæster: Peter Mark Lundberg, direktør i Dansk Teater Esben Marcher, sekretariatschef i Dansk LiveLars Refn, bladtegner Annette Carlsen, bladtegner Bob Katzenelson, bladtegnerVært: Ida Gaunø Tilrettelægere:Niels Frederik RickersMaria Asmine Dam Producer:Maria Asmine Dam Redaktør: Mille Ørsted

Be part of our community by joining our Facebook group: https://www.facebook.com/groups/thoughtbehindthings In tonight's conversation with our special guest, Aamir Ahsan. What was Amir's early life & education like? High school dreams & the route to GIK? Why did he choose computer science at that time? How did the ‘high barrier of trying' help him grow? how was the bond & connection of lifelong friends? How was Moving to Islamabad? What was it like growing up with inspiration in mind? The Department of Communication Security Vs. Ericsson? His role at Ericsson? What does Erricson do? Career progression & growth? Ericsson - A Global Delivery Center. Telecom, Enterprises,1H, & much more? The new concepts of Ericsson? Disrupting the concept of server boxes with high-speed internet? Getting into the IUT world? Providing security & upholding human rights? Consumer security Vs. Product offering? Is Ericsson trustworthy and secure? The future of telecom hardware & the global 5G race? Should location-specific licensing & connectivity be a thing? Why is the telecommunication industry suffering? Why does connectivity always come first? What is telecom like worldwide? Experience in Warid & going to Iran? Who is Iqbal in Amir's perception? Spirituality, self-discovery & inspiration. What is Amir's purpose in life? How does he see Pakistan 20 years from now? Catch this and much more in tonight's episode. Do not forget to subscribe and press the bell icon to catch on to some amazing conversations coming your way! Connect with us: • https://www.instagram.com/thoughtbehindthings • https://www.instagram.com/muzamilhasan Aamir's LinkedIn: https://www.linkedin.com/in/aamir-ahsan-khan-1078334/?originalSubdomain=tr One8nine Media: https://www.youtube.com/channel/UC6akyz6EpkwyzBmKh0L2rSQ Support our podcast: https://anchor.fm/syed-muzamil-hasan-zaidi3/support You can also audio stream our podcast on the following platforms: • Spotify: https://spoti.fi/3z1cE7F • Google Podcast: https://bit.ly/2S84VEd • Apple Podcast: https://apple.co/3cgIkfI --- Support this podcast: https://anchor.fm/syed-muzamil-hasan-zaidi3/support

Be part of our community by joining our Facebook group: https://www.facebook.com/groups/thoughtbehindthings In tonight's conversation with our special guest, Muhammad Sarmad Farooq. What has Sarmad's journey been like? What was it like growing up & then moving out of Talagang? What is manufacturing engineering and how did he end up doing it? What was his time at GIK like? What did he do post-graduation? What was it like working in Careem and how did his career progress? Careem's food delivery in Saudi and why wasn't the same model brought to Pakistan? Why did he quit? How did he end up thinking about starting Truck It In? What was Sarmad's family transport business and What was the marketplace like back then? Is there any value in this? How did they go about it? What has changed for the factory owner? Is it beneficial in terms of pricing? How do they earn money & Is it profitable? Were there any conversions? Is there any competition? Is the market heading towards it? The goal of their fundraising? What to expect & will they work on it? How does he envision the Pakistan of 2050? Catch this and so much more in tonight's episode. Do not forget to subscribe and press the bell icon to catch on to some amazing conversations coming your way! Connect with us: • https://www.instagram.com/thoughtbehindthings • https://www.instagram.com/muzamilhasan Sarmad's LinkedIn: https://www.linkedin.com/in/muhammadsarmadfarooq/?originalSubdomain=ae One8nine Media: https://www.youtube.com/channel/UC6akyz6EpkwyzBmKh0L2rSQ Support our podcast: https://anchor.fm/syed-muzamil-hasan-zaidi3/support You can also audio stream our podcast on the following platforms: • Spotify: https://spoti.fi/3z1cE7F • Google Podcast: https://bit.ly/2S84VEd • Apple Podcast: https://apple.co/3cgIkfI --- Support this podcast: https://anchor.fm/syed-muzamil-hasan-zaidi3/support

This month on Episode 40 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 2 and September 16 issues of the journal. This episode also features an interview with Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, from the City University of New York, about their study, Interaction of ARRDC-4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart.   Article highlights:   Jin, et al. Gut Dysbiosis Promotes Preeclampsia   Mengozzi, et al. SIRT1 in Human Microvascular Dysfunction   Hu, et al. Racial Differences in Metabolomic Profiles and CHD   Garcia-Gonzales, et al. IRF7 Mediates Autoinflammation in Absence of ADAR1   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting some articles from September 2nd, and September 16th issues of CircRes. And I'm also going to have a conversation with Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, from the City University of New York, about their study, Interaction of ARRDC-4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart. But, before I get to the interview, I'm going to highlight a few articles.                                       The first article is from our September 2nd issue, and it's titled, Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages, and Trophoblasts. The first author is Jiajia Jin, and the corresponding author is Qunye Zhang from the Chinese National Health Commission.                                       Preeclampsia is a late-stage pregnancy complication that can be fatal to the mother, and the baby. It's characterized by high blood pressure, and protein in the urine. The cause is unknown, but evidence suggests the involvement of inflammation, and impaired placental blood supply. Because gut dysbiosis can influence blood pressure, and inflammation has been observed in preeclamptic patients, Jin and colleagues examined this link more closely. They found that women with preeclampsia had altered gut microbiome. Specifically, a reduction in a species of bacteria that produced short-chain fatty acids, and lower short-chain fatty acid levels in their feces, in their serum, and in their placentas. And preeclamptic women had lower short-chain fatty acid levels in their feces, in their serum, and in their placentas compared with women without preeclampsia.                                       They found that fecal transfers from the preeclampsia women to rats with a form of the condition exacerbated the animals' preeclampsia symptoms, while fecal transfers from control humans alleviated the symptoms. Furthermore, giving rats an oral dose of short-chain fatty acids or short-chain fatty acid producing bacteria decreased the animals' blood pressure, reduced placental inflammation, and improved placental function. This work suggests that short-chain fatty acids, and gut microbiomes could be a diagnostic marker for preeclampsia. And microbial manipulations may even alleviate the condition.                                       The second article I want to share is also from our September 2nd issue, and it's titled, Targeting SIRT1 Rescues Age and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels. And this study was led by Alessandro Mengozzi from University of Pisa.                                       With age, the endothelial lining of blood vessels can lose its ability to control vasodilation, causing the vessel to narrow and reduce blood flow. This decline in endothelial function has been associated with age related decrease in the levels of the enzyme, SIRT1. And artificially elevating SIRT1 in old mice improves animals' endothelial function. Obesity, which accelerates endothelial dysfunction, is also linked to low SIRT1 levels.                                       In light of these SIRT1 findings, Mengozzi, and colleagues examined whether increasing the enzyme's activity could improve the function of human blood vessels. The team collected subcutaneous microvessels from 27 young, and 28 old donors. And both age groups included obese, and non-obese individuals. SIRT1 levels in the tissue were, as expected, negatively correlated with age and obesity, and positively correlated with baseline endothelium dependent vasodilatory function. Importantly, incubating tissue samples from older, and obese individuals with a SIRT1 agonist, restored the vessel's vasodilatory functions. This restoration involved a SIRT1 induced boost to mitochondrial function, suggesting that maintaining SIRT1 or its metabolic effect might be a strategy for preserving vascular health in aging, and in obesity.                                       The third article I want to share is from our September 16th issue. And this one is titled, Differences in Metabolomic Profiles Between Black And White Women and Risk of Coronary Heart Disease. The first author is Jie Hu, and the corresponding author is Kathryn Rexrode, and they're from Brigham and Women's Hospital, and Harvard University.                                       In the US, coronary heart disease, and coronary heart disease-related morbidity, and mortality is more prevalent among black women than white women. While racial differences in coronary heart disease risk factors, and socioeconomic status have been blamed, this group argues that these differences alone cannot fully explain the disparity. Metabolomic variation, independent of race, has been linked to coronary heart disease risk. Furthermore, because a person's metabolome is influenced by genetics, diet, lifestyle, environment and more, the authors say that it reflects accumulation of many cultural, and biological factors that may differ by race.                                       This group posited that if racial metabolomic differences are found to exist, then they might partially account for differences in coronary heart disease risk. This study utilized plasma samples from nearly 2000 black women, and more than 4500 white women from several different cohorts. The team identified a racial difference metabolomic pattern, or RDMP, consisting of 52 metabolites that were significantly different between black, and white women. This RDMP was strongly linked to coronary heart disease risk, independent of race, and known coronary heart disease risk factors. Thus, in addition to socioeconomic factors, such as access to healthcare, this study shows that racial metabolomic differences may underlie the coronary heart disease risk disparity.                                       The last article I want to share is also from our September 16th issue, and it is titled, ADAR1 Prevents Autoinflammatory Processes in The Heart Mediated by IRF7. The first author is Claudia Garcia-Gonzalez, and the corresponding author is Thomas Braun, and they are from Max Planck University.                                       It's essential for a cell to distinguish their own RNA from the RNA of an invading virus to avoid triggering immune responses inappropriately. To that end, each cell makes modifications, and edits its own RNA to mark it as self. One type of edit made to certain RNAs is the conversion of adenosines to inosines. And this is carried out by adenosine deaminase acting on RNA1 or ADAR1 protein. Complete loss of this enzyme causes strong innate immune auto reactivity, and is lethal to mice before birth. Interestingly, the effects of ADAR1 loss in specific tissues is thought to vary. And the effect in heart cells in particular has not been examined.                                     This study, which focused on the heart, discovered that mice lacking ADAR1 activity specifically in cardiomyocytes, exhibit autoinflammatory myocarditis that led to cardiomyopathy. However, the immune reaction was not as potent as in other cells lacking ADAR1. Cardiomyocytes did not exhibit the sort of upsurge in inflammatory cytokines, and apoptotic factors seen in other cells lacking ADAR1. And the animals themselves did not succumb to heart failure until 30 weeks of age. The author suggests that this milder reaction may ensure the heart resists apoptosis, and inflammatory damage because, unlike some other organs, it cannot readily replace cells.   Cindy St. Hilaire:        Today I have with me, Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, and they're from City University of New York. And today we're going to talk about their paper, Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in The Ischemic Heart. And this is in our September 2nd issue of Circulation Research. So, thank you both so much for joining me today.   Jun Yoshioka:             Thank you for having us. We are very excited to be here.   Cindy St. Hilaire:        It's a great publication, and also had some really great pictures in it. So, I'm really excited to discuss it. So, this paper really kind of focuses on ischemia, and the remodeling in the heart that happens after an ischemic event. And for anyone who's not familiar, ischemia is a condition where blood flow, and thus oxygen, is restricted to a particular part of the body. And in the heart, this restriction often occurs after myocardial infarctions, also called heart attacks. And so, cardiomyocytes, they require a lot of energy for contraction, and kind of their basic functions. And in response to this lack of oxygen, cardiomyocytes switch their energy production substrate. And so, I'm wondering if before we start talking about your paper, you can just talk about the metabolic switch that happens in a cardiac myocyte in the healthy state versus in the ischemic state.   Jun Yoshioka:             Sure. As you just said, that the heart never stops beating throughout the life. And it's one of the most energy demanding organs in the body. So, under normal conditions, cardiac ATP is mainly derived from fatty acid oxidation, and glucose metabolism contributes a little bit less in adult cardiomyocytes. However, under stress conditions such as ischemia, glucose uptake will become more critical when oxidative metabolism is interrupted by a lack of oxygen. That is because glycolysis is a primary anaerobic source of energy. We believe this metabolic adaptation is essential to preserve high energy phosphates and protect cardiomyocytes from lethal injuries. The concept of shifting the energy type of stress preference toward glucose, as you just said, has been actually long proposed as an effective therapy against MI. For example, GIK glucose insulin petition is classic.                                       Now, let me explain how glucose uptake is regulated. Glucose uptake is facilitated by multiple isophones of glucose transporters in cardiomyocytes. Mainly group one and group four, and the minor, with a minor contribution of more recently characterized STLT1. In this study, we were particularly interested in group one because group one is a basal glucose transporter.                                       Dr Ronglih Liao, and Dr Rong Tian's groups reported nearly two decades ago that the cardiac over-expression of group one prevents development of heart failure, and ischemic damage in mice. Since they are remarkable discoveries, the precise mechanism has not yet been investigated enough, at least to me. Especially how acute ischemic stress regulates group one function in cardiomyocytes. We felt that this mechanism is important because there is a potential to identify new strategies around group one, to reduce myocardiac ischemic damage. That is why we started this project hoping to review a new mechanism by which a protein family, called alpha-arrestins, controls cardiac metabolism under both normal, and diseased conditions.   Cindy St. Hilaire:        That is a perfect segue for my next question, actually, which is, you were focusing on this arrestin-fold protein, arrestin domain-containing protein four or ARRDC4. So, what is this family of proteins? What are arrestin-fold proteins? And before your study, what was known about a ARCCD4, and its relationship to metabolism, and I guess specifically cardiomyocyte metabolism?   Jun Yoshioka:             So, the arrestin mediated regulation of steroid signaling is actually common in cardiomyocytes. Especially beta, not the alpha, beta-arrestins have been well characterized as an adapter protein for beta-adrenergic receptors. Beta-arrestins combine to activate beta-adrenergic receptors on the plasma membrane, promote their endosomal recycling, and cause desensitization of beta-adrenergic signaling. Over the past decade, however, this family, the arrestin family, has been extended to include a new class of alpha-arrestins. But unlike beta-arrestins, the physiological functions of alpha-arrestins remain largely unclear based in mammalian cells. Humans, and mice have six members of alpha-arrestins including Txnip, thioredoxin interacting protein called Txnip, and five others named alpha domain-containing protein ARRDC1 2, 3, 4 and 5. Among them Txnip is the best studied alpha-arrestin. And Txnip is pretty much the only one shown to play a role in cardiac physiology.                                       Txnip was initially thought to connect alternative stress and metabolism. However, it is now known that the Txnip serves as an adapter protein for the endocytosis of group one, and group four to mediate acute suppression of glucose influx to cells. In fact, our group has previously shown that the Txnip knockout mice have an enhanced glucose uptake into the peripheral tissues, as well as into the heart. Now, in this study, our leading player is ARRDC4. The arrestin-domains of ARRDC4 have 42% amino acid sequence similarities to Txnip. This means that the structurally speaking ARRDC4 is a brother to Txnip. So, usually the functions of arrestins are expected to be related to their conserved arrestin-domains. So, we were wondering whether two brothers, Txnip, and ARRDC4, may share the same ability to inhibit the glucose transport. That was a starting point where we initiated this project.   Cindy St. Hilaire:        That's great. And so, this link between ARRDC4, and the cardiac expression of gluten one and gluten four, I guess, mostly gluten one related to your paper, that really wasn't known. You went about this question kind of based on protein homology. Is that correct?   Jun Yoshioka:             That is right.   Cindy St. Hilaire:        And so, ARRDC4 can modulate glucose levels in the cell by binding, and if I understand it right, kind of helping that internalization process of glute one. Which makes sense. You know, when you have glucose come into the cell, you don't want too much. So, the kind of endogenous mechanism is to shut it off, and this ARRDC4 helps do that. But you also found that this adapter protein impacts cellular stress, and the cellular stress response. So, I was wondering if you could share a little bit more about that because I thought that was quite interesting. It's not just the metabolic impact of regulating glucose. There's also this cellular stress response.   Jun Yoshioka:             Right? So, Txnip is known to induce oxidative stress. But about the ARRDC4, we found that ARRDC4 actually does not induce oxidative stress. Instead, we found that it reproducibly causes ER, stress rather than oxidative stress. So, let Yoshinobu talk about the ER stress part. Yoshinobu, can you talk about how you found the ER stress story?   Yoshinobu Nakayama: So, then let's talk about the, yeah, ER stress caused by ARRDC4. The ER stress caused by ARRDC4, year one was the biggest challenge in this study, because it's a little bit difficult to how we found a link of the glucose metabolism to the effect of the ARRDC4, only our stress. And at the other point of the project, we noticed that a ARRDC4 causes ER stress reproducibly, but we did not know how. So, both group one, and ARRDC4 are membrane proteins mainly localized near the plasma membrane. Then how does ARRDC4 regulate the biological process inside in the plasma radical? So, we then hypothesize that ARRDC4 induces intercellular glucose depravation by blocking cellular glucose uptake, and then interferes with protein glycosylation, thereby disturbing the ER apparatus. That makes sense because inhibition of group one trafficking by ARRDC4 was involved in the unfolded protein response in ischemic cardiomyocytes.   Cindy St. Hilaire:        So how difficult was that to figure out? How long did that take you?   Yoshinobu Nakayama: How long? Yeah. Is this the question?   Cindy St. Hilaire:        It's always a hard question.   Yoshinobu Nakayama: I think it's not several weeks. Maybe the monthly, months project. Yeah.   Cindy St. Hilaire:        Okay. It's always fun when, you know, you're focusing on one angle, and then all of a sudden you realize, oh, there's this whole other thing going on. So, I thought it was a really elegant tie-in between the metabolism, but also just the cellular stress levels. It was really nice.                                       So, you created a full body knockout of ARRDC4 in the mouse, and you did all the proper kind of phenotyping. And at baseline everything's normal, except there's a little bit of changes in the blood glucose levels. But I also noticed when you looked at the expression of ARRDC4 in different tissues, it was very high in the lungs, and also in the intestines. And so, I know your study didn't focus on those tissues, but I was wondering if you could possibly speculate what ARRDC4 is doing in those tissues? Is it something similar? Do those cells under stress have any particular metabolic switching that's similar?   Jun Yoshioka:             Well, actually we don't have any complete answer for that question, because like you said, we didn't focus on lung, and other tissues. But I could say that actually the brother of ARRDC4, Txnip, is also highly expressed in lung, and bronchus, and in those organs. So, it's interesting because, which means that, the molecule is very oxygen sensitive, I will say. Both brothers. But that's all we know for now. But that's a very great point. And then we are excited to, you know.   Cindy St. Hilaire.        Yeah.   Jun Yoshioka:             Move on to the other tissues.   Cindy St. Hilaire:        I was thinking about it just because I've actually recently reviewed some papers on pulmonary hypertension. So, when I saw that expression, that was the first thing I thought of was, oh, they should put these mice in a sugen/hypoxia model, and see what happens.   Jun Yoshioka:             Right?   Cindy St. Hilaire:        So, there's an idea for you, Yoshinobu. A K-99 grant or something. And also, because it's a full body knockout, even when you're looking at the heart, obviously the cardiomyocytes are really the most metabolically active cell, but cardiac fibroblasts are also a major component of the heart tissue. And so, do you know, is the, I guess, effects or the protectiveness of the ARRDC4 knockout heart, is it mostly because of the role in the cardiomyocytes or is there a role for it also in the fibroblast?   Yoshinobu Nakayama: Yeah, that's a very great question. Yeah. So, although we use the systemic knockout mice in the study, we believe that the beneficial effect of ARRDC4 deficiency is cardiac, autonomous. But this is because cardioprotection was demonstrated in the isolated heart experiments. But, you know, root is still uniformly expressing all cell types within the heart.                                       To address this, we have tested the specific effects of ARRDC4 on cardiac fibroblasts, and inflammatory cells. ARRDC4 knockout hearts had a twofold increase in myocardial glucose uptake over wild-type hearts during insulin-free perfusion. However, an increase in glucose uptake in isolated cardiac fibroblast or inflammatory cells was relatively mild, with about 1.2 fold increase over wild-type cells.                                       Thus we conclude that cardiomyocytes are the measure contributed to the cardiac metabolic shift. And then the mechanism within cardiomyocytes should play the major role in cardioprotection.   Jun Yoshioka:             I might, at one point, because, you know, the fibroblasts, they don't need to beat, right?   Cindy St. Hilaire:        Right.   Jun Yoshioka:             The inflammasome cells. They don't need to beat neither. So, they don't need that much energy. So, the cardiomyocytes energy metabolism is very important. So, that's why this mechanism is kind of more important in cardiomyocytes than other cell types.   Cindy St. Hilaire:        Yeah. And I think, you know, your phenotyping of the mice at baseline show that there's really no effect in a cell that's not under stress. So, it's really, really nice finding. Yeah.                                       This article, I should say, is featured on the cover of the September 2nd Circulation Research issue. And it's got this really nice 3D modeling of the binding of ARRDC4 to glute one. And I was reading the paper, and the methods said, you use some AI for that. So, I'm sure other people have heard, too, AI in protein modeling is important. But AI in art, right? There's that new DALL-E 2 program. So how are you able to do this? How did that work?   Jun Yoshioka:             So, our study used is called AlphaFold, which applies the artificial intelligence-based deep learning method. AlphaFold, nowadays, everybody really is interested in AlphaFold. AlphaFold uses structural, and genetic data to come up with a model of what the protein of interest should look like. So, that is also how we got the protein structure, ARRDC4. We think that the ability of AlphaFold to precisely predict the protein structure from amino acid sequence would be a huge benefit to life sciences, including of course, cardiovascular science research, because of high cost, and technical difficulties in experimental methods.                                       It's very useful if you can computationally predict the complex from individual structures of ARRDC4. And group one, which is actually structure of group one, is available in a protein data bank. But ARRDC4, it was not available. That's why we used AlphaFold.                                       And then we use the docking algorithm called Hdoc. So, based on these AI analysis, we could successfully identify specific residues in a C terminal arrestin domain as an international interface, that regulates group one function. So, we believe this AI method will pretty much accelerate efforts to understand the protein, protein interactions. And we believe that will enable more advanced drug discovery, for example, in very near future.   Cindy St. Hilaire:        Yeah, it's really great. I started thinking about it in terms of some of the things I'm studying. So yeah, it was really nice. Jun Yoshioka:             Try next time.   Cindy St. Hilaire:        Yeah, I will, I will. Actually, I went to the website, and was playing with it before I got on the call with you. So, how do you think your findings can be leveraged towards informing clinical decision making or even developing therapeutics?   Jun Yoshioka:             So, let me talk about what needs to be done. There are more things we must do.   Cindy St. Hilaire:        Always. Yeah.   Jun Yoshioka:             One of the most clinically relevant questions is whether ARRDC4 inhibition actually can mitigate development of post MI heart failure, and reduce mortality in the chronic phase, not the acute phase. Because in this paper we just did the seven day post MI, which is kind of like acute to subacute phase. But you never know what's going to happen in the chronic phase, right? And that is actually not so simple to answer because there are so many issues that you should consider. For example, Dr E. Dale Abel's lab has reported previously that cardiomyacites, specific group one, knockout in mice does not really accelerate the transition from compensated hypotrophy to heart failure. Also, the same group has shown that the overexpression group one does not actually prevent LV dysfunction in the mouse model of pressure overload. So, it is possible that ARRDC knockout can be, do much, or even harmful to LV remodeling in a chronic phase because chronic phase, it's not, it's getting hypoxy conditions, right?   Cindy St. Hilaire:        Yeah. So, it really might be something, I guess, personalized medicine is not the phrase I'm looking for. But I guess temporarily modulated, it would be something maybe we can figure out in an acute phase versus.   Jun Yoshioka:             Chronic phase.   Cindy St. Hilaire:        Yeah. Yeah.   Jun Yoshioka:             This makes sense. Because, you know, high capacity of ATP synthesis, by oxidating metabolism, could be important for chronic heart failure. So, it's selecting substrates. Energy substrates is no longer, you know, that issue. So, I'm not sure I'm answering your question, but this is the point that we consider to move on to the next.   Cindy St. Hilaire:        Well, that's great. And I think that was my next question, really. What is next? Are you really going to try to pinpoint where you could possibly target?   Jun Yoshioka:             Right. So, the first point we have to figure out about chronic phase, and another point we are interested in, is what's going on at the level of mitochondria. Does ARRDC4 knockout hearts have a different activity of electron transport chain or glycolytic enzymes within mitochondria?   Cindy St. Hilaire:        Or even mitochondrial fission infusion because it's, you know, it's a machinery.   Jun Yoshioka:             Yeah. And how about the other essential pathways in glucose metabolism such as mTOR, AMPK and HEF1, and so on. So, all these must be determined to help understand the more precise role of ARRDC4 in cardiac metabolism, we believe. Cindy St. Hilaire:        It's a wonderful study, and now we have even more questions to ask using your great model. Congratulations again.   Yoshinobu Nakayama: Thank you so much.   Cindy St. Hilaire:        Dr Yoshioka, and Dr Nakayama.   Jun Yoshioka:             Thank you.   Cindy St. Hilaire:        A wonderful paper, and congrats on getting the cover, and thank you so much for joining me today.   Jun Yoshioka:             Thanks well so much for having us.   Yoshinobu Nakayama: Thank you.   Cindy St. Hilaire:        That's it for the highlights from our September 2nd, and our September 16th issues of Circulation Research. Thank you so much for listening. Please check out our CircRes Facebook page, and follow us on Twitter, and Instagram with the handle @circres, and hashtag discovercircres. Thank you to our guests, Dr Jun Yoshioka, and Dr Yoshinobu Nakayama.                                     This podcast is produced by Ishara Ratnayaka, edited by Melissa Stonerm, and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research.                                       This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.

Hoppsan hejsan! I nästa del av försäsongskollen går vi igenom nykomlingen Gävle GIK och IBF FALUN.Alexander Rudd är tillbaka i SSL!! Simon Cederström!! Alexander Larsson!! Billy Nilsson!! Ahmad Aldeeb har joinat storebror på riktigt!!Med vänlig hälsning, Gustaf & Samuel Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Be part of our community by joining our Facebook group: https://www.facebook.com/groups/thoughtbehindthings In conversation with tonight's guest, Kashif Manzoor. What was his journey like? Why and how did he end up running away from Cadet College? How did he come to be a part of UET? How did he land in the field of computer science? How did he decide which university to attend? How did his four years at GIK go? What did he do post-graduation? What was the first job he had? What was his experience in China like? What was his role in Techlogix? Learning Chinese and what was it like to conduct interviews and make hiring decisions there? How big was the company? Completing the Master's degree, Rejoining Techlogix and why did he leave it? Switching to ORACLE and how did it go? How did he end up at Confiz Limited? What brought him to Systems Limited? What's going on in the IT world and at Systems Limited? Are new opportunities going to be created? Will we be able to maintain our growth and improve our work culture? IT sector growth Vs. startup growth? Are IT services essential for the growth of startups? How does he envision the Pakistan of 2050? Catch this and much more in tonight's episode. Do not forget to subscribe and press the bell icon to catch on to some amazing conversations coming your way! Connect with us: • https://www.instagram.com/thoughtbehindthings • https://www.instagram.com/muzamilhasan Kashif's LinkedIn: https://www.linkedin.com/in/kashif-manzoor-9197264?originalSubdomain=pk Systems Limited Website: https://www.systemsltd.com/ The Pakistan Pivot podcast: https://www.youtube.com/watch?v=sCnzyQYBT6g&t=1297s&ab_channel=PakistanNow TBT shorts: https://www.youtube.com/channel/UC6akyz6EpkwyzBmKh0L2rSQ --- Support this podcast: https://anchor.fm/syed-muzamil-hasan-zaidi3/support

Lige om lidt lytter du til Politiken, men hvad går du ellers og hører? Hvilken musik har du haft i ørene i 2021? Var det Pink Pantheress, som du først hørte på dine børns Tik Tok-konto? Eller Billie Eilish i radioen, mens du kørte på arbejde? Gik du og glædede dig til det store comeback fra Adele – eller ABBA? Hørte du det, som de algoritme-kloge musikere som Ed Sheeran sneg ind på din telefon? Politikens musikredaktør Simon Lund har hørt mere end de fleste og i dette afsnit fortæller han hvilken musik, der gjorde mest indtryk på ham i 2021.

#EP102: To gamle udtjente telefoner samles til én, der til gengæld virker. Mød to personer som går op i, at telefoner og elektronik skal leve i længere tid. Gamle telefoner skal genanvendes. Nogle gamle telefoner kan du tilmed få penge for, når du køber en ny. Hør også episode 1 om 'smid-væk-tech'. (Foto: Pixabay) I gamle dage, for ikke så mange år siden, var køb af højttalere, fjernsyn og selv telefoner en langtidsinvestering. Gik noget i stykker, kunne det sagtens fixes. Gennem nullerne skete der en ændring. Nu blev elektronikken oftere udskiftet og producerne lancerede nye produkter én til to gange om året. I dag kommer Apple og Samsung med 3-4 hovedmodeller på et år. Dertil kommer en LANG række andre lanceringer. Nu står vi med resultatet: Vi drukner i elektronikaffald. FAKTA: I 2019 var den globale mængde af elektronikaffald 44,4 millioner tons, ifølge The Global E-waste Monitor, 2020. Tallet forventes at ramme 77,4 millioner tons i 2030. Nyt liv til gamle telefoner Selvom en smartphone ikke kan tænde, skærmen er ødelagt eller batteriet er fladt, kan det stadig være penge værd. Foxway er et firma, som indsamler gamle telefoner, som de puster nyt liv i. Efterfølgende sælges de renoverede telefoner med to års garanti. - "Vi opkøber alle typer af enheder, både dem der fungerer og dem, som er beskadiget. Vi vil altid forsøge at tage to eller tre telefoner og gøre dem til én der virker. Restkomponenterne gemmer vi til reparation af andre telefoner. De ting, som slet ikke kan bruges, sendes til genbrug efter alle kunstens regler," fortæller Mikkel Frid, sourcingdirektør i Foxway. Når det kommer til at købe renoverede telefoner, er danskerne ikke firstmovers, men tendensen er opadgående i kraft af, at også store kæder som Telia, Power og Humac er begyndt at interessere sig for området. I f.eks. Humac kan man indlevere sin gamle udtjente telefon, uanset mærke, og få penge for den gamle, når man køber en ny. FAKTA: 70 procent af de adspurgte danskere svarer i en undersøgelse, som YouGov har foretaget på vegne af Humac, at de har mobiltelefoner liggende som ikke anvendes. Genbrug og langtidsholdbarhed er ikke en nyhed Grundlæggeren af HiFi Klubben, Peter Lyngdorf, er ikke typen, der falder på halen over nutidens snak om langtidsholdbare produkter og genanvendelighed. Peter bliver trist, hvis en 20 år gammel forstærker ikke kan reparaeres og få et nyt liv. Når der kommer nye produkter på hylderne, er det nu, som før i tiden, vigtigt for Peter Lyngdorf at de kan holde længe. - "I vores serviceafdeling har vi én mand, som ikke bestiller andet end at tjekke nye produkter og undersøge dem for forventet holdbarhed, strømforbrug. Hvordan de er opbygget osv. I forhold til snakken om miljø og genbrug, er det noget, som er ved at komme på nu. Vi holder os langt væk fra produkter, som kun kan holde i ganske få år," lyder det fra Peter Lyngdorf, HiFi Klubben. OMTANKE KOSTER IKKE EKSTRA: Umiddelbart lyder det dyrt, når en producent skal skabe produkter, der kan leve længere, men det behøver det ikke at være, lyder det fra Bang & Olufsen. Hør episode 1 om smid-væk-tech her. Mere til historien Foxway anslår, at danskerne ligger inde med omkring 12 millioner gamle mobiltelefoner.

Gik du glip af SEGES Svineproduktions webinar til slagtegriseproducenter, kan du nu høre highligts fra webinaret på bare 20 minutter. Her deler to rådgivere og en griseproducent deres praktiske erfaringer til at øge dækningsbidraget. Vil du vide mere efter at have lyttet til podcasten, kan du se hele webinaret og præsentationer på Svineproduktion.dk.

Et radio-talkshow med både sjov og alvor, hvor værterne Sara Otte og Dennis Johannesson kommer længere ind, og endnu tættere på deres gæster. Programmet tager revolverjournalistikken til nye højder med spørgsmål hentet i 'Den Russiske Roulette', ladt med spørgsmål fra tidligere gæster. Denne lørdag er der besøg af: Anders Morgenthaler - Uløseligt forbundet med tegneserieuniverset 'Wulffmorgenthaler', men har også instrueret en lang række film, og udgivet børnebøger. Nu gælder det Tv-serien 'Try Hard', om gamer-verdenen, på Viaplay. Josefine Høgh - Et kendt ansigt på DR Sporten, men også som vikar i 'Aftenshowet'. Til sommer skal hun være vært på EM i fodbold, og inden kan du se hende i en programserie om ekstremsport, sammen med astronaut Andreas Mogensen. Yepha - Kendt som den ene halvdel af duoen UFO Yepha, der gav os hits som 'Hver dag' og 'Op med håret'. Gik solo i 2012, men har også studeret skuespil og medvirket i flere produktioner. Nu er der ny musik klar, og i går kom første single.

I avsnitt 28 möter vi Billy Nilsson, forwardsstjärnan som efter flera år på högsta nivå i både Svenska Superligan och schweiziska toppligan har bestämt sig för att återvända hem till Gävle för spel i Allsvenskan med Gävle GIK nästa säsong. I poddavsnittet diskuteras bland annat:✔ Karriären från början✔ Turerna kring landslaget✔ Att växa upp utan sin mamma✔ Mohikanfrisyren✔ Gävles chanser i Allsvenskan nästa år Hosted on Acast. See acast.com/privacy for more information.

In this episode, Hugh and Dan discuss: Interview with Lightning eMotors Co-Founder and CEO Tim Reeser, Their SPAC Merger with $GIK, This Week in the Market, Bitcoin/Weed/Capitol-Craze, and SPACS! 21-year-old millionaire Hugh Henne and his host, Dan, Deity of Dips dive into the stock market in a fun yet informative way (Prod. by Vinny Strokes and Starsky). The above references and Podcast are an opinion and are for information purposes only. It is not intended to be investment advice. Seek a duly licensed professional for investment advice.

GODT NYTÅR! Vi skal i dagens program se nærmere på de 8 største øjeblikke på LOUD, som alle gik glip af, da ingen hørte med. Vi skal se på dengang der gik ild i studiet, da Gantimir tog til USA, Dronning Margrethe blev interviewet i GAMEBOYS, da vi gik i luften for tidligt og meget mere! Dette gør vi i et program fyldt med champagne, stjernekastere, sjove hatte og en krukke med MDMA.Vi har gennem hele 2020 forsøgt at finde lykken og sørge for, at det ikke blev det værste år nogensinde. Vi har stadig ikke fundet lykken, men heldigvis har vi stadig et par timer tilbage af året.

Året er ved at være omme, så Gantimir og Sebastian sætter sig og ser tilbage på en masse højdepunkter (og især lavpunkter) som vi har oplevet igennem 2020. I dagens program ser vi tilbage på nogle af de faste indslag og formater, som vi har fundet på hen over året. Vi skal snakke om vores kunstige intelligens LytterTron3000, vi skal lære Gantimirs far at kende igennem hans kunst, vi læser i manuskripter til Borgen og Obamas bog og så dykker vi ned i Gantimirs fortid som bandeleder i Døgnrapporten.

Året er ved at være omme, så Gantimir og Sebastian sætter sig og ser tilbage på en masse højdepunkter (og især lavpunkter) som vi har oplevet igennem 2020. Målet for idag er, at se tilbage på nogle af de mærkværdige telefonopkald som vi har foretaget og modtaget i løbet af året. Vi skal blandt andet snakke om, da vi fik vores allerførste opkald i form af den faste lytter Claes, dengang et P1-program forsøgte at pranke Loud, da vi satte Politiken på plads og da vi fandt en telefon, som kunne ringe til fortiden.

Gik du glip af DJ Faustix' ekstra morgenfest, i GO'NOVA, i morges? Bare rolig, du kan nemlig høre den igen, lige her.

Gik du glip af Martin Jensens fredagsmix i GO'NOVA? Bare rolig, du kan høre det hele igen, lige her.

Pues no, no hablamos de nuestra Waifu en este capítulo, sino de los vehículos más increíbles del mundo Gik. Ready Player Gik Podcast con Charlie, Alan y Alfi. No te olvides de compartir tus opiniones y seguirnos en: Facebook Escríbenos a: readyplayergik@gmail.com Grupo de Whatsapp: https://chat.whatsapp.com/HqqJGjEKl2H3WCoU29bdwr

Las últimas noticias del mundo Gik están aquí, entérate en RPG Podcast con: Alfi, Alan y Charlie. No te olivides de compartir tus opiniones y seguirnos en: Facebook Escríbenos a: readyplayergik@gmail.com Grupo de Whatsapp: https://chat.whatsapp.com/HqqJGjEKl2H3WCoU29bdwr

Endelig, endelig, endelig er vi tilbage i din radio igen og selvfølgelig i stærkeste opstilling. Selv om coronasituationen langt fra har sluppet sit tag i vores hverdag, har vi nu fået lov at sende igen. Og hold nu k**t vi har glædet os! Da dele af Danmark stadig er lukket ned, ved vi, der er mange, nye lyttere. Derfor får vi nogle af de garvede lyttere til at sende os nye forsyninger af sedler til Bjørnen. Og så er der Simon, der aldrig har hørt Danskerbingo før, men han sender os på jagt efter Mikkel, der engang brækkede sig i chok, efter han troede, at han havde kørt et menneske ihjel. Mens vi har været væk, er der startet en ny radiokanal, nemlig Radio Loud, der har kæmpet med lyttertallene. På baggrund af den historie finder vi frem til Theresia, der aldrig fik anerkendelse for sit hårde arbejde på efterskolen - hvor ingen drak te. Vi skal selvfølgelig have fundet et nyt led til vores "Sjovt Du Sir' Det"-kæde. Den anonyme lytter Steffen... Gik engang meget langt... I hvert fald 700 meter i trods. Johnny gik også en tur i trods. Lad os bare sige, den var lige lidt længere end Steffens 700 meter. Vores 3D-printede Bjørne Corydon er også tilbage efter lockdown og vil gerne finde nogle, der er kommet til at hoste på et virkelig dårligt tidspunkt. Kristian hiver sin date med på McDonald's. Daten ender med burger i håret, men Kristian endte alligevel i dobeltsengen. Caroline Clante har nyheder med til dagens Nyhedsbingo. Med en "sjælden" sejr til Jacob, leder vi efter nogle, der virkelig fortryder at have besørget i det fri på baggrund af, at rigtig mange kommuner har valgt at lukke deres offentlige toiletter grundet corona. Bjarne tissede op af politistationen i Skagen. Vores gamle ven, golf-passeren Michael, tjekker også ind og fortæller om, dengang han fik en bøde på 50 dollars for at tisse i det fri. Andreas har alene drukket sig rødvinsfuld til en digital brætspilsaften og må forlade sin "fest", da den hvide telefon ringer. Vi leder efter andre, der har dummet sig i solo-branderter under lockdown-perioden. Det har Jimmy, der efter sin solofest med en kuffert rødvin, vågner nøgen midt i et hidsigt lysshow og fuldt udsyn for naboerne. Værter: Andreas Kousholt og Jacob Weil.

Las últimas noticias del mundo Gik están aquí, entérate en RPG Podcast con: Alfi, Alan y Charlie. No te olivides de compartir tus opiniones y seguirnos en: Facebook Escríbenos a: readyplayergik@gmail.com Grupo de Whatsapp: https://chat.whatsapp.com/HqqJGjEKl2H3WCoU29bdwr

Onsdag betyder podd och det är dags för det 39:e avsnittet av Rasta Möter (fortfarande Göteborgs ENDA renodlade lokalfotbollspodd)! I detta avsnitt träffar vi 4A-laget Guldhedens IK:s trotjänare Magnus Karsvall (för tillfället assisterande tränare)! Vi pratar om de småländska rötterna, den egna fotbollskarriären men självklart blir det mest fokus på hans engagemang i Guldhedens IK! Vi försöker redan ut om GIK är ett mittenlag eller ett topplag, rivaliteten i centrala Göteborg men vi blickar även framåt mot den (förhoppningvis) kommande säsongen! In och lyssna!   Podden drivs och produceras av Fredrik "Rasta" Airosto och synpunkter kan skickas till rastaochdalla@rastaochdalla.se  

Las últimas noticias del mundo Gik están aquí, entérate en RPG Podcast con: Alfi, Alan y Charlie. No te olivides de compartir tus opiniones y seguirnos en: Facebook Escríbenos a: readyplayergik@gmail.com Grupo de Whatsapp: https://chat.whatsapp.com/HqqJGjEKl2H3WCoU29bdwr

Hablamos de la legendaria serie que nos crió: Los Simpsons en Ready Player Gik. Además de darte todo el contenido Gik que tanto te gusta. Escríbenos a: readyplayergik@gmail.com Síguenos en: Facebook Grupo de Whatsapp: https://chat.whatsapp.com/HqqJGjEKl2H3WCoU29bdwr

Denna gång intervjuar jag en glad Markus Åkerfelt som säger att det är tre sköna poäng och tre viktiga poäng. Där Hagunda IF vann med 9-6 mot Gälve GIK. Mer […]

Dan Hooker hev en tæt sejr i land på hjemmebane, da han slog Paul Felder i UFC Aucklands main event. Gik dommernes decision den rigtige vej? Det taler vi om. Der var masser af action og masser at snakke om, ovenpå weekendens event og ligeså en buket af nye, spændende matchups. Støt podcasten via vores nye Patreon - https://www.patreon.com/enpaapoden Klik ind på Bambuni.dk og brug koden 'mmamedia', når du køber dit bambus-tøj, så får du 10% rabat! Lyt med med og vær en del af MMA-debatten på vores Facebook: En På Pod'en og vores Instagram: @enpaapoden

Her er vores store “Året der Gik”-speciel! Vi har hver især lavet en top 10 over de bedste film fra 2019. Der bliver skældt ud, rullet med øjene og jublet. Så glæd jer og lyt med! Støt Film Snak: 10er.dk Med støtte på 10er hjælper du os med at drive vores podcast, men du får […]

¿Qué contenido nuevo e interesante se viene el 2020?. tus Gik favoritos te comentamos lo que más esperamos de este año. Una divertida tertulia sobre Gikismo. Síguenos en: Facebook Escríbenos a: readyplayergik@gmail.com

Poptillægget har i de sidste ni afsnit dykket ned i, reflekteret over og udvalgt netop de popkulturelle strømninger, som har defineret 2010'erne. Det fejrede Poptillægget og IBYEN med en stor farvelfest til 10'erne på Johan Borups Højskole, hvor også det tiende og sidste afsnit i serien blev optaget live på scenen med to helt særlige paneler. Første panel bestod af tre madkyndige stemmer i vores tid, som diskuterede 2010'ernes gastronomiske vokabular. Det blev til en snak om surdej, fermentering, burgerkrige, pokebowl, smagen af grøntsager, naturvin og København som kvalitetsbevidst mekka. Derudover havde vært Lucia Odoom inviteret et panel bestående af fire unge mennesker, som fortalte, hvad de tager med sig af popkulturel visdom fra det forgangne årti, og hvad de håber for det nye årti.  Gik du glip af festligheder, eller har du bare lyst til at opleve dem igen, kan du høre det i dette årtis absolut sidste afsnit af Politikens Poptillæg. Vi ses i 2020! Festens gæster: 1. Andrew Moyo: Radiovært på P3 og somelier2. Eva Hurtigkarl: Kok og arrangør af festivalen 'Søndagsvenner'3. Sune 'Hipster Glistrup' Albinus: Filminstruktør og tidligere radiovært i rollen som 'Hipster Glistrup' på Radio 24Syv4. Oskar Fehlauer Nielsen: Skribent på SEIN5. Karoline Staustrup: Efterskolelev6. Elias Zakarias Sadaq: Digter, har skrevet, produceret og udgivet sin egen digitale digtsamling 'Gadestreger'7. Jonas Torstensen: Ejer af pladeselskabet 'Kornmod', laver radio og er DJ Vært og tilrettelægger: Lucia Odoom. Producer: Kathrine Eggert Wadsholt. I redaktionen: Sille Westphal og Nina Kragh.

El regalo perfecto para tu waifu o husbando está aquí en Ready Player Gik. las mejores ideas si no sabes que conseguir en esa época de fiestas. Además las mejores noticias de la semana. Gik, Tu mundo, tu contenido.

Las películas que nos marcaron y que nos hicieron adictos al contenido, las pelis de la infancia y las que siguen marcando nuestras vidas. Gik – Tu mundo, Tu Contenido

Todo lo que tienes que saber sobre las últimas novedades del universo de StarWars. Jedi Fallen Order y The mandalorian. Solo en Gik, Tu mundo, tu contenido.

Si eres un Pokefan o no no importa, te contamos todo lo último del mundo de Pokémon, además nuestras opiniones del juego de la 8va generación de la entrega Pokémon Espada y Escudo. – Invitado Especial Pablito Pericón. Todo lo mejor está en Gik!

Hvad med ungerne? Ny podcast på gaden i dag.   En af de spørgsmål jeg tror, jeg har fået stillet flest gange er 'Hvad med ungerne? ' Hvordan skal de klare sig? Hvad med sprog? Hvad med venner? Går de ikke glip af rigtigt meget, når I lever som I gør? Det er både fra min egen familie, mine venner, og fra jer der følger med, er med til foredrag og lytter til podcast. Jeg forstår godt det kan være svært, når børnene ikke vil med, har deres egen mening, eller bedsteforældrene mener at man 'stjæler' deres børnebørn. Men i stedet for, at jeg fortæller om, hvad de der børn får ud af det, så har jeg i dagens udsendelse interviewet børnene selv. Mød mega seje Gustav Rosentoft ( Ja det er Cille, min nye samarbejdspartnere søn) på 17 år, der  går i 1 g, og i dag fortæller, hvordan det var, da hans forældre fortalte ham midt i hans teenageår, at nu ville de fandme ud og sejle jorden rundt. De ville have et ny tilværelse, langt væk fra det der plejede at være normalen. Og børnene skulle selvfølgelig med. Jeg kan godt allerede her afsløre at Gustav ikke var glad for deres beslutning. Hør Gustavs refleksioner om det at rejse ud i verden. Hør hans virkelig modne refleksioner, her 4 år efter og hvad han har fået ud af at sejle to år på havet med sin familie. Ville han mon gøre det igen? Gik han glip af noget? Synes han det var svært? Få alle svarene i dagens podcast der har fokus på de 'satans' dejlige unger. Du får samtidig et hurtigt indblik i Liva og Elva på 10 års refleksioner og min søn på 12 år, der også kort fortæller, hvordan de så det at rejse jorden rundt med deres familie. Så fra 10-17 åriges refleksioner til dig i dag. Denne her podcast er ikke kan for dig der har børn, den er for alle, fordi vi faktisk kan lære noget af børns måde at se verden på, deres nysgerrighed og ikke mindst deres ærlighed. Så und dig selv at lyt til Gustav, du kan som voksen helt sikkert også lære noget.   Tak fordi du er her .Tak fordi du lytter. Og tak fordi du støtter den digitale nomade Kærligst Mille og Gustav

Te comentamos nuestras películas, series y juegos de terror favoritos. además de todas las ultimas noticias Gik de la semana. ¿De qué te disfrazaste en halloween? – ¿Qué es lo que más terror de produce? Escríbenos: www.facebook.com/revistagik www.revistagik.com www.facebook.com/tdlbolivia https://www.boliviajovenradio.com www.reddit.com/r/readyplayergik Encuéntranos en nuestras redes Sociales: Carlos Aspiazu: Facebook: https://www.facebook.com/carlos.aspiazu.351 Twitter: https://twitter.com/MADCHARLIE PSN: snakecharlie Alan…

Diese Frau weiß, was Verbraucher wollen: Im Dienste der großen Verlage geht Catherin Anne Hiller mit ihrem Team unserem Marken-, Medien- und Konsumverhalten auf die Spur. Das tut sie als Geschäftsführerin der Gesellschaft für Integrierte Kommunikationsforschung – kurz GIK. Was Marken stark macht und ob wir jetzt wirklich alle nachhaltig ticken, sagt uns Catherin Anne in der neuen Folge #MoCM.

Starting out with agriculture doesn’t have to be hard. But farmers need a plan how to access land, capital and means of production. Elizaphat Otieno Opiyo, Technical Officer for the NGO REFSO, about five important steps everyone should take that ventures into agriculture. 
 Pur gi Ohala Chenro 2: Gik moko 5 ma japur onego ong‘e Chako weche mag pur ok onego obed gima tek. Kata kamano jopur onego obed kod chenro mar yudo puodho, pesa kod kaka ginyalo nyak. Elizabeth Otieno Opiyo, ma en jalony e migao mar REFSO ma en riuruok ma oken mar piny owacho chiwo twak ewi gik moko 5 ma ng’ato ang’ata onego opar ka odonjo e weche mag pur.