Podcast appearances and mentions of Priscilla Chan

Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of frontier AI and biological data, that goal may have been too conservative. In this episode, Elad Gil and Sarah Guo sit down with Biohub co-founders Mark Zuckerberg and Priscilla Chan, alongside Biohub Head of Science Alex Rives. Together, they discuss Biohub's $500 million virtual biology initiative, which integrates frontier AI with wet-lab work to build predictive world models of cells, proteins, and systems. They also talk about their newly announced open-source engine for digital protein and antibody design, ESMFold2; why Biohub is a nonprofit rather than a venture-backed startup; and how hierarchical simulations will soon allow doctors to treat patients at an individual, mechanistic level.   Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @Biohub | @finkd | @alexrives | @ChanZuckerberg Chapters: 00:00 – Cold Open 01:02 - Mark Zuckerberg, Priscilla Chan, and Alex Rives Introduction 01:26 – Why Biohub and Their Mission 08:27 – Integrating Frontier AI and Frontier Biology 09:45 – Micro to Macro Biological Modeling 14:22 – Mechanistic Interpretiability  16:58 – Why Biohub is a Non-Profit 21:41 – Understanding How Biology Works 24:23 – Timeline for Curing All Diseases 26:25 – Translating Research to Patient Impact 28:04 – Launch of ESMFold2 32:13 – Tackling Off-Target Effects and Edge Cases 38:39 – Putting the Tech in Individual Hands 41:06 – Talent at Biohub 44:25 – What's Next After ESMFold2 46:10 –  Connecting ESMFold2 to Agentic Systems 46:51 – The Virtual Cell 49:33 – Defining Success for Biohub 51:52 – Biohub Strategy Update 56:20 – Conclusion

Fontes do episódio aqui:⁠https://portal.afya.com.br/podcasts/afya-news/29-05-2026Nesta sexta-feira, analisamos a preparação da vigilância sanitária para grandes eventos, as atualizações diagnósticas da ASCO e a revolução tecnológica no desenvolvimento de fármacos. Começamos com a articulação sanitária internacional entre México, EUA e Canadá contra o Ebola às vésperas da Copa do Mundo, destacando os reflexos para a vigilância do SUS no Brasil. Detalhamos as novidades do congresso da ASCO, incluindo o uso de testes genómicos como o Prosigna para poupar pacientes com cancro de mama de quimioterapias desnecessárias. Por fim, abordamos no Radar o lançamento de uma IA global de biologia proteica pelo Biohub, de Zuckerberg e Priscilla Chan, focada em projetar ligantes para reativar células imunes. Afya News. Informação médica confiável e atualizada no seu tempo.

Smart Fit expõe dados de clientes após sistema de catraca inteligente ser vazado.Google permitirá a troca de endereço do Gmail; entenda o que muda. Disney+ amplia lista de benefícios para assinantes; confira novidades. Nubank ganha jogos que dão cupons e descontos na Shopee, Uber e Samsung. Streamer é suspensa da Twitch após jogar Dark Souls usando os pés em live. Zuckerberg e Priscilla Chan lançam IA para acelerar descoberta de medicamentos. CD Projekt Red revela Songs of the Past, nova expansão de The Witcher 3: Wild Hunt. Google inaugura centro de engenharia na USP com foco em privacidade, segurança e IA.

So who boycotted and who just didn’t get invited? Yes, we’re rounding out the Met Gala gossip with a rundown of protests (SJP?), basic-b*tch heartbreak (Hugh & Sutton) and bathroom selfies (alllll the hot ones). VOTE FOR US: Help Out Loud win the People’s Choice category of the Australian Audio Awards. Find the link to vote RIGHT HERE. Plus, who actually won in the finally-finished court battle of Lively vs Baldoni vs Lively? And what James Valentine’s Year Of Living Gratefully taught us about living (and dying) well. And, Cameron Diaz is a mum again at 53 and no-one is calling it a 'miracle!' Have we turned a page on older parents’ double standards? Don’t forget that if you SUBSCRIBE to Mamamia, you get access to extra Out Loud segments, every single one of our podcasts, and every MM story ever written. https://www.mamamia.com.au/subscribe/ SUBSCRIBE here: Support independent women's media What To Listen To Next: Listen to our latest episode: Fake Nips & Wandering Hands: Mia’s Met Gala Verdict Listen: We Do Not Agree On The Taxi Cab Theory Listen: She Opened The Fridge. What She Found Ended Her Friendship. Listen: The Real Reason You Resent Your Friends Listen: The One Minute Of Live TV That Undid A Noughties Icon Listen: Scurrilous Gossip: An Engagement, An Affair & A Royal F-You Listen: The Family Ritual That Has Us Divided Listen: The Most Honest Dating Questionnaire We've Ever Seen Connect your subscription to Apple Podcasts Discover more Mamamia Podcasts here including the very latest episode of Parenting Out Loud, the parenting podcast for people who don't listen to... parenting podcasts. SUBSCRIBE here: Support independent women's media You can now watch our show in full length video on the Apple Podcast app - make sure your phone is up to date and we can't wait for you to see Mamamia Out Loud on Apple What to read: Blake Lively just got the last laugh at the Met Gala. Blake Lively and Justin Baldoni have just settled their lawsuit. The timing says everything. Cameron Diaz quit Hollywood for 10 years. When she returned, she noticed one major difference. 'As a fashion editor, I urgently need to discuss these 9 Met Gala looks in excruciating detail.' THE END BITS: Check out our merch at MamamiaOutLoud.com GET IN TOUCH: Feedback? We’re listening. Send us an email at outloud@mamamia.com.au Share your story, feedback, or dilemma! Send us a voice message. Join our Facebook group Mamamia Outlouders to talk about the show. Follow us on Instagram @mamamiaoutloud and on Tiktok @mamamiaoutloud Mamamia acknowledges the Traditional Owners of the Land on which we have recorded this podcast. - - - - - - - - - - - - - - - - -AUTO GENERATED TRANSCRIPT: Speaker 1: Hello and welcome to Mamma Mia out Loud. It's what women are actually talking about on Wednesday, sixth of May. I'm Holly Wainwright and the first thing I'm going to do, the first order of business, very simple out louder is if you love your show, please vote for us in the upcoming Australian Audio Awards as a People's Choice category. It's really straightforward. We're going to put a link in the show notes, We're probably going to put it on social We're going to put it everywhere. We would love your support to help us get there. That is the end of my manifesto for the day. Speaker 2: Okay, Well, I just would like to say as a lazy girl that there are all these things to fill out. Speaker 3: You only have to fill us out. Speaker 1: Yeah, you don't have to do everything is just tick Mama Mia out Loud. Speaker 3: So important for the lazy girls out there, and as as a bossy girl, I just concur with Holly. I know you can make that ask of people, and I think that's a great step towards greet our self assertive. Speaker 1: I'm growing, I'm growing, Amelia Growing. I'm Amelia Lester and I'm Claire Stephen and here's what's made our agenda for today. So now that it's all over and many damning text messages scatter the ruins of what was the biggest celebrity story for a couple of years, Just who did win in the whole? Blake Lively and Justin Baldoni court case drama. Speaker 3: Plus Cameron Diaz is a mother again at fifty three, and Holly has some thoughts. Speaker 2: And veteran broadcaster James Valentine filmed the last year of his life for the ABC, and between a living wake and his openness around voluntary assisted dying, he's opened a conversation around what it means to die a good death. Speaker 1: But first, Amelia Lester, the Mecgala. Speaker 3: Did it feel different this year? A lot of people said that it did. Amy Odell, a fashion writer, wrote in her background newsletter that the Metgala was all money, no soul, and she wasn't alone in this criticism. Basically, people are saying that because Jeff Bezos and his wife Lauren Sanchez Bezos sponsored the event, it just started to feel a little craven, a little gross, and less fun than it used to be. So there were a lot of protests in New York. In the lead up to the event, they were all centered around Amazon's labor practices, its environmental damage. And then there are those who say, no, that's not true. The mech color's always been about rich people giving their money towards a good cause, which is the Metropolitan Museum's Costume Institute. And look, they did raise a lot of money on Monday night. The Bezos has bought the event for about ten million dollars, but then the event itself raised about forty one million. This is US dollars, which is a lot for this event. It's apparently kind of record breaking. So are we just complaining about nothing, Holly? Do you feel like celebrities stayed away? Did they agree that this was a sort of off event this year? Speaker 1: So I'm going to give you a list of the celebrities who people say boycotted, because none of the people so far who everyone is saying has boycott had actually verbalized that they were boycott. Speaker 3: Well, we are boycotted, which we just had to take a stand because. Speaker 1: I do feel a little bit like what soul when you said it's all money those salt like, I do feel a bit that I don't think this is the first year. It has been pointed out in the culture, particularly since trump Ism and all those things, that this feels very hunger games. Yes, yes, and I know although there's a more direct link here, you know, with the Bezos is buying it. I do feel like Jeff sort of bought it for Lauren as a gift, which is a nice gift. Nice, but it feels more avert. So anyway, let's look at this because when I was watching it on Tuesday and then I did a subscriber episode with me as straight afterwards, I was like, well, all the celebrities are there, like Beyonce's there. All the famous people I was expecting to be there were there. Speaker 2: Well, actually a lot of famous feom we didn't expect to be there were there. Speaker 1: Yeah. And then it was pointed out to me who was not Billie Eilish. Now that tracks because she doesn't like billionaires, and she remembers she gave a speech a while ago where she said, you lot give more of your money away. So I don't think she would have been either welcome or willing to go, because Jeff might have worried that she was going to shake him down in the bathroom to share more of his money. Zoe Saldana, she is somebody who is usually there. She was not there. She is almost as rich as the billionaires. She is an unbelievably well paid actress because of her Marvel and Avatar connections. So Zoe's at home count of dollars. Olivia Rodrigo that tracks too. She is political, That would not be surprising. She's in the middle of an album promo, so you might have usually expected her to be there. Lady Gaga an interesting one because she could have been expected to be there because she's in The Devil Wears prior of Too and the rest of the Well. Meryl wasn't there, but Meryl never goes, so that's not surprising. But Anne Hath the way Emily Blunt Stanley Tucci were all there. Speaker 2: Stanley Tucci with Emily blount sister, it's always fun. Speaker 1: So maybe Gaga, but also she's kind of said lately that she's going to focus on promoting things she wants to promote rather than just being around. Lewis Hamilton come on, like he's literally dating Kim Kardashian, who's extremely bezos adjacent. I don't think that was a political. Speaker 3: Let's get to the big guns. Some were missing, right, some who we might have realized. Sarah Jessica Parker. Speaker 1: Yeah, so, Sarah Jessica I reckon. That is probably I would say that's almost definitely a boycott. But she went to support Anna at a dinner, but she didn't. Speaker 3: Go to the There was a dinner on the weekend before the gala. It probably would have been more fun. Speaker 1: Anyways, she said anything, No, she hasn't, but she I think she was in support of the New New York mayor. Right, And obviously he didn't go, but then I wouldn't have expected him to go, and he did post about it. They posted a series of let's sell a the real heroes of fashion and you know, celebrated workers behind the scenes and particular designers and things. So yes, so Sarah Jessica Parker I reckon could be a boycott. But then they're saying, you know, j Lo, I don't think Jalo was boycotting. I just think she's tired. Speaker 3: Harry Styles. Speaker 1: Harry Styles is in the middle of record of rehearsing for his tour. He's in a studio in bethnal Green running through it. Not that I've been stalking him. Justin Bieber, he's just done Coachella. Boy needs to lie down. Miley Taylor Swift, she never goes, and I don't think she's so. I think that some of the boycott cots are not boy I. Speaker 3: Think that's right. But it's interesting that some of the tech billionaires it clearly got to them a little bit. So it's interesting that Jeff did not walk the red carpet with Lauren. That's very unusual. They do everything together. We've learned this from various pieces about them and Lauren's dress being very boring. Do we think that was intentional. Speaker 1: A little bit understated for Lauren, Yeah, but I think it was had a very specific art reference. It was the same dress as someone called Madame X and it's like scandalous women. Speaker 3: Yep. It's interesting though, because Jeff did walk the carpet in twenty thirteen when Amazon sponsored the event. There was no outrage back then when Amazon sponsored the event and he walked with Mackenzie then Mackenzie Bezos his wife at the time. Mark Zuckerberg also made his Met Gala debut with his wife, Priscilla Chan, and they also didn't walk the red carpet, which I thought was interesting because it's kind of like, well, you want to be at the glamorous event, but you don't want the attention of being there. Speaker 1: Do you think they might have been encouraged not to. Speaker 3: I don't think anyone encourages Mark Zuckerberg and Jeff Bezos to do anything would have worked exactly. But there were some tech willionaires who did walk the carpet. Google founder Sergei Brinn. He showed up on the red carpet with his girlfriend. Her name is Gaylyn Gilbert Soto. The New York Times describes her as a con conservative gut health influencer. Speaker 1: That is one of the six job title Claire. Speaker 3: Do you think that there's something inherently conservative about gut health? Speaker 2: Yeah, because gut health is very don't take antibiotics and don't take antibiotics is very That's what it's. Speaker 1: Yeah, yeah, yeah, yeah, which used to be a sort of crunchy hippie vibe, but these days has come back around it. Speaker 3: I thought it was just you know, drink your com your chart, but no, it means it can. Speaker 2: Be very I feel like there's it's a short road from like gut health gut health to to anti vacs. Don't ever give your children antibiotics with my sour crow. Speaker 3: And of course I'm AROUNDA was there. I just have to add she was there with Snapchat founder Evanstein on the carpet, of course. Speaker 1: Possibly the biggest gun that I haven't mentioned though, is Zendaya. She does always go. Usually she didn't go, and that read like a boycott. And some people are saying, if your boycotting, say you're boycotting. I don't think so necessarily. You don't want to necessarily make everything about your politics. But I just have one question. I think that big charity galas of all types have always been, have always reflected the moment therein and they've always been a path to accessing status in a particular society. Watch the Gilded Age, It's all about that. Speaker 3: And Nixon notably said that she thought it was great that the mayor didn't go. Speaker 1: Yes, but like you know, you're reflecting the time. So you're going a big gala ball is the way you get all the fancy people together. This being a tech bro billionaire ball is very reflective of the moment we're living in, right, So is it surprising in any way in the nineteen eighties New York society. It was all about glitz and flash and Donald Trump, and now we're like again, I don't know. I kind of feel like, what did we expect to happen? Speaker 3: No, that's right, But I think that the group that people are most angry at it's not the people who went in their pretty dresses. It's not the people who didn't go and stay quiet about it. It's the people who went but then tried to have their cake and eat it too. See. Speaker 2: I'm not as frustrated about this because Sarah Paulson is getting a hole at a crap because she wore a dress that then and then had a blindfold that was a dollar bill, and it was people like it's making a statement about about like eating the rich. Speaker 3: Well, she herself said that it was a statement about the one. Speaker 2: Besides yes, and and I thought that was like a far swing. But the dress is actually called like the one percent by the artist, the designer who designed it, and the mask was called blinded by Money, and it was a statement on greed and corruption that comes with extreme power. I think it's a little bit unfair to look at her and say, well, you've got a net worth of twelve million dollars at which how does anyone calculate anyone's net worth on the internet? But you have a net worth of that you're at this event, how dare you then make a protest when it's like, well, isn't that exactly how how you do it? Speaker 3: Don't you go in? And well, people do have a history of using that platform. So Alexandra Ocazio Cortez, who is a Democratic congresswoman from New York, famously wore a dress on the Megala red carpet a couple of years ago which said tax the rich. But people actually have the same criticism for her. To your point, Holly, the met Gala in some corners has always been seen as a kind of repulsive show of excess and decadence, and she got a lot of aoc got a lot of flak for even attending the event back then, reading the canapasey while saying. Speaker 1: You guys are discussing while Charlie free directions. Speaker 2: But if you're not there, you don't have a microphone to say anything about the event, do you know? Well, I guess you do. I guess like Vende could opposed to something on Instagram. Speaker 3: If you want Zendaya not going definitely took the air out of the room when that announcement came out, And I guess it wasn't an announcement so much as a news update. Everyone kind of went, that's big. When Zendeia's not there, it's big. Speaker 2: Because she's always one of the coolest on the carpet. Does something really original, remember that, like bloody light up dress and she. Speaker 3: Oh, but there was a bathroom selfie. Some things always stay the same, right, and you saw this by Yes, it's always an iconic bathroom selfie. It's always the thing you want to look for. And there was an amazing one that had you know, the Margo Robbie all the people in it. But one of the things that was most striking about that And so I saw that in the wild last night and I was like, why is there an exceptionally beautiful woman in the middle of that who is wearing a quarter zip sweatshirt? I was like, was she at that party? Speaker 1: And then it's having a lot of headlines today because she is actually a very famous model. Speaker 3: Yeah, I actually love the story behind this. Her name is Bavitha Mandava and she that what she wore was a quarterzip jumper essentially and what looked like jeans. It turns out they weren't just any jeans. The jeans were made with silk muslin and had a blue denim effect. My jeans today have a blue denim effect. And it's a very important iconic look because she opened Chanell's show in December, which was on the New York City Subway, wearing essentially that outfit, and the fashion world lost their mind. That show was like considered extremely groundbreaking, and she was the first Indian model to open a Chanel show and she is now the first South Asian ambassador for Chanel. And incidentally, did you notice that Margot Robbie, who was also Chanel ambassador, It was right next to her in that photo. So Chanell must have been just so happy about the whole thing. Speaker 1: I know, but it just she just looked so out of place. Speaker 3: But that's what made it so good. Speaker 1: Yeah, but I was like wandered into the shop. But she also read all about it and I was amazing. Yet she didn't have to have a bubble machine boobs. Speaker 3: And then that look that she wore on the Chanel catwalk was actually a nod in turn to how she was discovered. I love this so much. She was a grad student m YU and she was discovered on the New York City subway waiting for a train. One would imagine probably wearing a similar outfit to the one she is now wearing in a much more fabulous incarnation at the metgala. Speaker 1: But you were obsessed with another red carpet walk. Speaker 2: Yes, because I am a basic bitch. If, like I swear, if there was like a thermometer for like, what's what does the basic bitch think about anything that's happening in the world right now? It comes over me and it's like bing bing bing bing bing because I saw the red carpet photos of Hugh Jackman in Suton Foster and I think I was sitting opposite you and Holly and I. Speaker 3: Said, oh oh, was like I don't and I'm like, howm my. Speaker 1: Here has it been? Speaker 3: Now? Not that many at least well he was. Speaker 2: Hugh Jackman was on the Red carpet with Debory Furnace in twenty twenty three. Speaker 3: My group chats are very divided on this. Some love the two of them together and some are talking about deb Prowley. Speaker 1: Do you have to not debut your relationship after a divorce five years, ten years? What do we want? Speaker 2: There are no rules, but I am allowed to go oh poor deb Oh, no, I hate that I am allowed. And then the tabloids, because again I'm a basic bitch. The tabloids were like, hey, basic bitches, We've made up a story for you. So there are sources in Inverata commas who say that Debrale Furnace was a huge fan of the event and the decision to bring Sutton Foster was a final blow to deb And what I didn't realize when I went really deep on this was some Foster's wearing a ring, like they think that you proposed in January and they think they're going to have some trend in your wedding. Speaker 1: And is that all are not allowed? He's not allowed to marry again, not ever, not ever. Speaker 3: I I don't know about that. Speaker 1: How do you know that, Deborah Lee Furness. This is what I don't like about this narrative is it victimizes a woman who maybe is totally done with that, you know what I mean. She obviously she made up some statements that made it clear she was not happy when that relationship broke down, But again three years ago, so now she might be living her absolute best life. Thank god I don't have to go to the met gala with that guy. Speaker 3: She disagrees politically too. We don't know anything about it, like she was kind of famously a conservative political voice because he is the godparent of Rupert Murdock and Wendy Dang's children. Also, he's very close with Avanka Trump. So no one was surprised to see Hugh at the slightly maga codd metgala. Speaker 1: Oh wow, he's unfair, And I know no one's crying for the celebrities, but I think it's unfair to brand everybody who was at that red carpet as maga. Speaker 3: Co Oh no, no, no, I did too, But I just I'm saying that he's not exactly Alexandra Orcasio Cortez. No one would be expecting him to make a big political statement about the taxing the rich. No, he's very like to promote. Speaker 1: In a moment, what the heck was all that Baldoni Lively business about? If we've both basically ended with nobody winning and no money changing hands. So moments before one Blake Lively swept onto the met gala carpet looking a bit like Cinderella, very trademark minus the bluebird. She didn't happen. She always said exactly body, She's pretty good all that stuff. But moments before that, a statement dropped into the inboxes of major press outlets, including People, New York Times and so on, and it read the end product the movie. It ends with Us is a source of pride to all of us who worked to bring it to life. And with no context, Everyone's like, why are we reading this? Raising awareness and making a meaningful impact in the lives of domestic violence survivors and all survivors is a goal that we stand behind. It becomes clear this is a joint statement from Blake Lively's team and Justin Baldoni's team about the court case we've all been obsessed about for years. We acknowledge the process, presented challenges, did it. Speaker 3: Recollections and recognized concerns raised by mes Lively deserved to be heard. Speaker 1: We remain firmly committed to workplaces free of improprieties and unproductive environments. This is one of those statements that so many lawyers were involved in drafting that it. Speaker 3: I hate an unproductive environment and I'm with that. Speaker 1: That's fair. It is our sincere hope that this statement brings closure and allows all involved to move forward constructively and in peace, including a respectful environment online. And in the hope of moving forward constructively and in peace, Blake goes to the met gal Yeah, yep. Now we'll get to whether or not they got their respectful environment online, But just a very quick catch up, because we would be here for a year if we went into all the ins and outs of what's been going on here. But it all started when Blake Lively. Do I need to explain who she is? Significant star actress, possessor of wonderful hair, one half of a very powerful Hollywood power couple, made a movie called It Ends with Us, based on one of the best selling books in the past decade by Colleen Hoover. Speaker 2: And you guys are weird about it because I said this morning that it's objectively one of the worst movies I've ever seen. And you guys, it's fine. You guys were so mad well. I didn't stop you so mad well. Speaker 1: I'm gonna get to that in a minute. The thing is is that making a movie based on one of the best selling books of the decade is smart business and lots of people wanted to do it. But the man who owned the rights was Justin Baldoni, who's a lesser known dude. He's an actor, producer, self proclaimed feminist. Done. Some Ted talks about it. Speaker 3: Everything I know about this man I've learned against my will exactly done. Speaker 1: Some Ted talks about it podcast with Liz Plank something something something. Anyway, the movie itself is about domestic balance. That is not a mystery or a surprise at his front and center in the plot. The movie got made, and the movie was a huge hit, proving Claire Stephens wrong. Speaker 3: All I need to say. Speaker 1: Against the modest production budget of twenty five million, it grossed around three hundred and fifty one million dollars. Huge movie, right, But before the hit part happened, obviously, it was obvious that things were for apart. Behind the scenes, everything had gone very very wrong. We're not going to take you through because again I know Klas Stevens has a PowerPoint on this somewhere. You It went very deep at the time. You were a great source of it. Speaker 3: It was great. A lot of this was going down. Speaker 2: I think maybe just as I submitted my books, and my reward to myself was finish your book and you can read all the legal poculars. Speaker 1: Yes, and there was this press tour that was like separate red carpets and warring factions and all this stuff. And then in December twenty twenty four, Lively sued Baldoni, accusing him of harassment, sexual misconduct, and a smear campaign on the set of their movie. She claimed that Baldoni conspired with publicists to preemptively destroy her reputation, hence the dodgy press tour after she privately accused him of sexually harassing her on the movie set. There were a lot of damning texts released, all hell broke loose. Then Baldoni countersued. He basically alleged that Lively and her husband Ryan Reynolds always wanted to take over this movie, the control of the script, to the edit, all the things that they had it in for him, and they used their very famous friends to intimidate and harass him. Speaker 3: I'll never forget the email that when unanswered, that she sent to Matt Damon. Speaker 1: Oh, I know. There were a lot of damning texts revealed. Speaker 2: Again, sorry, the one to Ben Affleck where she like, oh, she just made an awkward joke about how she had sent the email to Matt Damon and how great Matt Damon was, and I was like, honey, that's like Ben Affleck's biggest point of in security is comparing himself to Matt Damon and you don't know the idiots and your correspondence with Ben. Speaker 1: And so here we are suddenly, just weeks before this mess was all going to go to court, all these cases have been it. Speaker 3: Hadn't even gone to court. Speaker 1: No, some things had been dropped dropped. So first of all, Baldoni's case against Lively got dropped, and some elements of Lively's case against him got like so there was all that was stuff, but it was it was meant to go to court I think on May eighteen, so soon. Wow, And days before it's been disappeared. Lawyers have made millions, reputations have been trashed and nobody apparently no money exchanged hands between the two parties, and no one, as you as evidenced by that really confusing press release, nobody is saying that they've won or not. Claire does the fact that Blake Lively stepped onto the met Gala carpet the minute that happened signaled that she sees this as victory or that she'd liked to pretend the whole thing didn't happen, And how the hell does she move forward? Speaker 3: Yeah, Claire, what does that mean that she shot up at the Metgala? Speaker 1: One? Speaker 2: I think it's genius. I always think that the best publicity in response to this stuff is to be around and change the narrative, like changing a different direction. Celebrities are so clever that it is no coincidence that this statement came out when it did and that then she was on a red carpet, because you just you know that there's so much going on in the world. People are going to be all the celebrity reporters are going to be distracted, just like the zones. Speaker 3: Yes, yes, And. Speaker 2: It's the same reason it always happens. When I was editor in chief, the local Australian celebrities would always announce their breakup at like five pm on a Friday, and it's like, you know. Speaker 3: The journals have gone to drinks or boxing day. Speaker 2: Yeah, yeah, you know, we've gone to drinks, you know that West Skeleton stuff on the weekends. Speaker 3: We're not going to go as hard on this story. Speaker 2: So I think it was smart that it was released when it was, and it was smart that she turned up at the met gala and that she reminded everyone I look really good in address. Speaker 1: You to figure but disagree because what immediately happened the minute she opened her mouth. Speaker 2: Well, this is what's interesting that depending on your algorithm, and depending on what side of the Internet you're on, there are two very different stories. So on certain apps, the story I'm saying is this was a win for Blake Lively that, for example, the line at the end of that statement including a respectful environment online, that that was very much acknowledging what had happened to her, which was all the allegations about manufactur orchestrated campaign. Speaker 1: Because that is the thing that I will take away from this mess the most, is that seeing the messages between Baldoni's press people and him about ways that you can use and manipulate social media to dent somebody's reputation is not just like when you see suddenly start seeing everywhere lots of tiktoks around of like, look at this interview with this person, doesn't she come across a bit like this but there can be a lot more behind it. And this is also things that we pointed out about amber Hood joining the amber Hood Johnny deppcayse that there can be a really orchestrated dark arts going on there, and certainly the examples that were pinging back and forward between Justin Baldoni and his reps suggested that I knew that. Speaker 2: Yeah, And so there's there's a lot of arguments that that line in particular is about what she went through, because she really has been torn apart on the internet. However, I couldn't believe that she turns up at the met Gala. She there's she clearly you could actually tell from her speaking when she was interviewed that she was nervous, that she was trying, like, I can't put my foot in it. Speaker 3: I can't like that. Speaker 2: There have been viral interviews of her for a couple of years now all over the Internet of her just saying slightly the wrong thing in an interview, and it becomes that she's an awful person. Blake Lively did an interview on the met Gala red carpet and it has been analyzed to death, and people think she was rude to the interviewer in this instance, well, you look gorgeous. Speaker 4: I am wearing Jackson weederhot gorgeous, thank you beautiful hair. She yeah, you look studying. And this is archival versace, but they met a fid it by adding a big beautiful train. So it's a piece from two thousand and six. And it was just such an honor to be able to wear this gorgeous, gorgeous gown. It looks like a sunrise and a sunset and watercolor and gorgeous range shworts, jewelry. But this this, but these, this is a Judith leberbag. And we were trying to find a piece of famous iconic art to put on and make it look like it was in a frame. And then I said, would you actually, if you're gonna make it custom, would you do my kid's art? So my kids each painted a painting, a watercolor painting. So each of my four kids did this. Speaker 1: That is so spoo especial. Speaker 4: So I have them with me. Speaker 2: And that has been interpreted as her being a bit, as her being dismissive, as her being self scentered. The other thing that's been I think we want to know what this is. Speaker 1: So here's my challenge to your strategy, be public, give them things to talk about, because she can't get away from this narrative now for some time, it's been years of her lit like every time she opens her mouth. There's a lot of people invested in you're a terrible person, as you say, so they're just going to find ways to say that over and over again. In the way that the Internet is now very invested in hating Blake Lively a certain so, just in the way that the internet's very invested in hating Megan Markele. It doesn't matter what she does, what she says, where she goes. You can't win that game. Speaker 2: One of the great arguments was it costs one hundred k for a plate at the Met gala, and part of her claim was the financial stress caused by Baldoni smear campaign. And it's like she's not paying for that one hundred k plate, neither is anyone people being like I thought you were arguing you were locked out of Hollywood. Speaker 3: Doesn't look like you're locked out of Hollywood. Speaker 2: And she had a bag where her interpretation of the art theme was that she got her four kids to draw a picture on each side of the back no self centered, made it about you. Speaker 3: You wanted to. Speaker 2: Claim authorship over this event, So there are people. Speaker 1: This is why I think her best strategy is to go away for a few years. Speaker 2: Yeah, because I think the weird thing is I think if Justin Baldoni had turned up, I think there's something, there's an anonymity that we give men that we just don't give women like I just don't think he is going to be plagued in the same way. And I think it's Marina Hyde who says he'll probably do some low budget it. Speaker 1: Will definitely have dented his possibilities of becoming a big name. I think that because, as Marina Hyde says in that story in The Guardian, she wrote a column about this, saying that the overarching lesson of this whole thing is never ever go to court, never ever ever. And they didn't actually end up in court, but still is that for the rest of time. Their names are now linked, every interview, every pro file, every project they do. This will always be part of the story in a way that it wouldn't if it hadn't entered the courts. But when I say I think go away free, I don't mean disappear like I don't mean silencing women. I mean work on projects, work on producer projects, hustle behind the scenes, do all your hollywoody stuff until you can come back to address this with more nuanced Look at Lena Dunnan. We've been talking about that a lot lately. Famously one of the most hated women on the internet for a period of time, couldn't put a foot right, couldn't do anything right, opened her mouth, everybody jumped on her. We know how the culture treats women who speak out about all kinds of things. There are local examples of this too. In a way. You've got to like let the air out of it and then come back when there's some nuance and distance. Speaker 3: You know what I mean That her while best friend Taylor Swift would have told her that too, because Taylor, of course also famously disappeared and was getting around in large boxes for a while just to stay out of the public eye. That comment of Marina Hides about never go to court is interesting because a few years ago, someone in a professional context did something to me that made me want to take them to court, and so I went to talk to a lawyer about it, who have been recommended to me, and the lawyer heard me out. I was very grateful for the advice she gave me. She said, look, I think you have a strong case, but if you did this, everyone in your field would say that you were a nightmare, no matter what happened in the court case, no matter how right you are, and I do think you're right, it would affect you professionally and it would follow you professionally for the rest of your life. And I think getting that advice from someone who had kind of a monetary gain to taking the case on was something I really appreciated. And I just wonder if Blake Lively's legal advice turned out to be deeply misguided. Speaker 1: I know. The sad thing about this argument I've never taken to court is, of course, that women putting up with sexual harassment at work are just always this guy from ever doing anywhere with it, because you're going to get your character smeared. And it might be on the scale of a Blake Lively, or it might be just the local gossip at the football club, like whatever it is, and that it's like we've seen this play out in massive letters across the sky that watch out, women will get you one way or another, and whether or not Blake Lively is particularly likable, is always nice to everybody? Blah blah blah, isn't the point? Speaker 2: Yeah, it is quite scary for women knowing that if you pursue, which is what an element of what Blake Lively was pursuing, a sexual harassment claim, that all your texts will be looked over and mocked and made fun of. Like, that's a really scary cost to pay. After the break James Valentine and why everyone's talking about the concept of a living wake. On the twenty second of April of this year, cast out musician and author James Valentine died age sixty four, leaving behind his son, his daughter, and his wife. The ABC veteran had terminal cancer, and he was widely loved by his audience, who had been listening to him for three decades. He had been transparent over the last two and a half years about his health. He was a very talented saxophone player and anyone who grew up in the eighties in Australia probably knows him as part of the band The Models and their iconic songs Barbados and Out of Mind, Out of Sight, and he was a Sydney radio presenter. Emilia and Holly, what was your connection to James Valentine as a radio personality? Speaker 3: He was a really important figure in my childhood. He hosted a thing called the Afternoon Show on ABC when back when there were forty TV channels in this country. I remember those days, and he would host and it was cartoons, it was variety. And I never really listened to him on the radio, but I have such you know, in the way that those childhood figures loom large for you. I've always held such fondness and affection for him. And how about you, Hollie. Speaker 1: He's clearly just an incredibly skilled communicator. I mean, I would be lying if I said I listened to that show. But anyone who knows how radio works, how the ABC works, so many people I know who know him. He was just clearly exceptionally good at what he did and very loved. Speaker 2: It's a reminder I think that parasocial relationships have existed long before the Internet. The fact that when the news of his death came out there was a widespread kind of public grieving and a lot of listeners who called in the next day, and his wife and his kids were kind of saying how much that meant to have people remember their dad through sense of humor and his energy. So two and a half years ago he was diagnosed with esophagal cancer and he was given two different treatment options, and he chose the one that was a bit less invasive and would preserve the things he loved in life, which were presenting radio, playing saxophone and enjoying food. Then in January of this year, he's given a terminal diagnosis and his response to that diagnosis and what he planned to do next was documented in Monday's episode of Australian Story, presented by Lee Sales, and it started a huge conversation about the concept of a living wake, which he very fittingly held on Valentine's Day of this year. Here's what he said on the show stage. Speaker 5: Four, terminal, inoperable, uncurable. I don't want to hear any of those words, let alone in the one sentence. So a friend suggested Tommy, maybe you should do a living wake, and oh, that sounds like fun. I will know the time and the day and so it'll be the last weekend. What do you do on that last weekend's dinner? Before? What do you think is that the last meal, I will probably know exactly when I'm going. Speaker 1: That's so moving. So seeing the footage of his reference at the end there was due to the fact that he ultimately chose the time he was going to die, right. Speaker 2: Yeah, he chose voluntary assisted dying and was very transparent around how he made that decision and what that decision entailed. For context, voluntary assisted dying is legal in all states in Australia and the Act except the Northern Territory, and obviously it's an incredibly complex and incredible, incredibly personal decision that has sparked. It's sparking more and more conversation the more we have and aging population and the more people are getting certain diagnoses that may keep them alive for a very long time, but the quality of that life may be poor, and him kind of taking people through that decision was a huge part of the Australian story. But it meant that he got to plan this living wake and there's footage of it, and he's got his family and friends there and there are so many familiar ABC faces and he's really good friends with Norman Swan, who he had on radio to discuss his diagnosis, like what all the different parts of the body were and what they did. And there was something so moving about seeing him on stage with a microphone at his own wake, basically saying, please come up to me and tell me stories and memories about us, because they are what's going to carry me through the next few weeks. And I guess I thought it must be such a relief for his family that then when you do a funeral, he's heard all the beautiful things that you're then going to say about him. I think this is really something we should we should all be looking at. Speaker 1: If it's possible, this episode of Australian Story is really recommended viewing. I think, whether you know who James Valentine is or not, in a world where we hate to talk about death, and yet it touches everybody obviously, I mean that's a ridiculous thing to say, but it does touch everybody. I'd lost a friend to this same cancer when he was only forty six. It's like all cancers. It's a it's it's cruel and the idea that we're also we don't like talking about illness, we don't like talking about death, and seeing somebody such a skilled communicator like James Valentine in this episode talking about why he wanted to do the things he did, and they document the year so very like him talking about how very much clarified for him that he loved his work, so he didn't want to stop working. He loved playing his saxophone, so he wanted to try and avoid procedures that were going to stop him from doing that. That he really wanted to work, play and be with his family, and those are the things he wanted to spend his last year doing. It's just it's very powerful, it's very clarifying. And then to see him at his living way and he says, you know, it wakes People always say, oh, he would have loved me there, and he says, so I wanted to be there, And I just think it's very refreshing. I think, you know, I, as I said, I didn't have a direct listenership with Joe's Valentine, but people who do, and people I know who've worked with him said he brought joy all the time. And it feels like a gift to give be so honest and so open and so clear eyed in talking about this thing that nobody wants to talk about. Is like the last incredible gift that a great communicator could give, and his family is so amazing in it. I really recommend watching the show. Speaker 2: There's a great quote in one of the ABC articles about his kind of decision making towards towards the end, where I think, as a psychologist says, dying people are not the actual act of dying is not the thing they're most scared of. They're scared of the invisibility and the absence of conversation around it. They're scared of people turning away and not wanting to be around them because of how confronting it is. And this was just such a reminder to look it straight in the eye and have the existential conversations with the people around you. The way that he spoke to his kids, and his kids were able to say, what do you think is going to happen afterwards? Speaker 3: And I bet that that's so much harder to do than even it looks. It doesn't look easy, but I bet it's even harder to actually enact these principles that we can all agree are worthwhile. Speaker 1: I love that his kids say that this was perfect for him in particular, this living weight, because he loved being center of attention. He loved a party, He loved being told I'm brad he was. I love the way they you know that families are really kind of I mean, I'm sure no families are perfect, but they're really healthy and loving when they can just call out that stuff about you and be like, he would love this because he just loves everybody tell him how great he is. Speaker 3: So good. Speaker 2: Yeah, And I loved that it wasn't a sanitized version because I think something I always bristle at is when you hear of somebody getting a terminal diagnosis or of you know, knowing that they're going to die. I bristle at the narrative of I guess almost toxic positivity that they're just like, well, I'm completely grateful and joyful. And then I feel for the people who don't have that response, which is completely bloody normal. But I loved there was a lot of light and shade in this. They talked about they went on a holiday, a family holiday to Bali, just before he was meant to get the surgery for his esophagus, and that the whole family's like, oh so bloody terrible holiday. Everyone was sick, everyone had covid Dad. Speaker 3: Had BALI belly like. It's sort of I like that. Speaker 2: In documenting this time, they've been able to show the highs and lows of what happened. But the nort Yeah, how normal it is. But the fact that he was able to do it his way, and that those conversations around what you want, what you don't want, they give so much empowerment in those in those final months and final days. Speaker 1: Something completely different. There was celebrity baby news this week that I must mark because it was interesting. Cameron Diaz and Benji Madden just welcomed their third child. And it's interesting because Cameron is fifty three. Now. When I say that, I don't mean it's interesting in that way of like, oh, miracle baby, how did she do that? Why did you do that? Cameron Diaz. They announced that their little boy had come. They announced what his name was. His name is Nortous and he joins Raddix and Cardinal, which are all just the most rock star names of all time. They announced it. They didn't give any more details than that. It is safe to assume just because Cam's been on a press tour lately, she's been quite visible on a tour for a movie called Outcome, So she's been very visible, and it's safe to assume possibly that she wasn't heavily pregnant during that time, so likely that a surrogate was involved, but none of our business. But the thing that I found really interesting and refreshing that I wanted to unpack a little bit here is I wrote an essay a while ago when Sienna Miller was on the Red Carpet with her beautiful baby bump at I think forty three, and saying how we're entering a bit of an era of agelessness because perhaps of fertility technology, because of the different options that are open to us now, because of Hollywood and the wellness world's obsession with longevity, that we're in a different era now when it comes to age and women and kids. And I think nothing illustrates that more clearly than the fact that there haven't been a whole waterfall of stories about like, oh my god, a mom at fifty three and how could she and why would she? And da da da da. Is that now we're much more kind of like in the way that we might be about a man becoming a father at fifty three, because if you remove the biological complication from the advance for chility technology and all those things. It isn't really any different than the guy who's been doing that forever. Yeah, am I right? Yeah? Speaker 2: No, I think so too. The interesting thing is, as well, when I've looked at this story, how old Benji Madam? Well, nobody ever, as I don't know, I don't know, why didn't I. Speaker 1: Google similar age? I think, well, let's find it happen. Speaker 2: Yeah, because you're seven, so being a little bit younger Benji's forty seven, bloody spring chicken. But I it's interesting because whenever I see pregnancy baby news, it's obviously the life stage. Speaker 3: I'man, I always google. Speaker 1: How old is how? Speaker 3: How old is that? Speaker 1: Money is she? Speaker 2: And you're right that we don't when we wouldn't blink an eye at a man having a child at fifty three. And obviously, if you want to think about any of the things that make rearing children. Speaker 3: Difficult, the older you get. Speaker 2: I mean, Amaran Diaz looks like a bloody pillar of health. She's gonna live forever, She's gonna live till she's undred. Speaker 3: Well, I think what's interesting is that you said no one will blink, and I about a man. I wonder if, now, because women are also having babies older, all of a sudden, we're starting to blink her eyes at men having babies older. Men were allowed to do it for all of human history, but now that women are starting to do it, we're starting to revisit the whole idea of older parents because. Speaker 2: We are interested, and there is actually more and more scientific research going into the health impacts of older because you know how, I'm called geriatric. Just for the record, I'm a geriatric mother. What age, I'm thirty five years old. No, they don't. They call it advanced material. Speaker 3: They definitely call it just it's kind of coolrophistic. Speaker 1: They definitely did call it geriatric though, when I had my second child at forty, I that's interesting. Speaker 2: But if they call Brent geriatric, no, but they should have done it because he's elderly, I think. Speaker 1: I think that's interesting. But then that also assumes. Speaker 3: Like the judgments creeping in for both sexes now, is what I'm saying. Speaker 1: Yes, and that assumes the idea about like we're becoming aware of the risks of older parents assumes assumes a lot about what might be going on here biologically. Yes, exactly, whereas if Cameron Diaz and Benji Madden and whoever else may be in their cohort are having are assessing all the risks, I'm sure they are. We know how health obsessed Hollywood is and making those choices, and there I think. I don't know that's interesting though, Amelia, where you say that that maybe the judgment, instead of fading away, just attaches itself to both genders. Speaker 3: Well, because I don't think it is just about biology. I think it would be we need to put on the table to not be disingenuous. That a lot of people listening to this may have a reaction of if you have a baby at a more advanced age, shall we say, in your fifties, you automatically do a bit of maths, and you think, well, when that child in school, Cameron Diaz will be sixty three. I don't know how old Benji Madden will because I'm not that good at maths, but he'll be also kind of old. And so I think that's one of the concerns that people are now voicing a little bit more when no one ever used to say, well, Mick Jagger is going to be so old when his kids graduate but now we are starting to say that or feeling perhaps feeling more comfortable to say that. Speaker 1: I think that's really interesting. But then I think in this privileged bubble that we're talking about, longevity is an obsession. So I think that that is also changing. This right is that people are thinking rightly, wrongly whatever that with all the right advances and all the right supplements and all the right that they're imagining themselves at seventy three, at this kid's twenty first, like leaping around, I'm doing yoga and pilate, particularly if they. Speaker 2: And Brian Johnson says he's got what is it the sperm of a twenty old? Think about that, man, Yeah, So I'm sure Cameron and Benji are having the same conversation. Speaker 3: So Cameron has remember she literally wrote a book about sort of how to be healthy as you get older, so she's this is clearly on her radar that she's sort of anticipating she will be living a long time. Speaker 1: That's always got time for on this Wednesday. Speaker 3: At births, deaths, any marriages, No. Speaker 1: There weren't any couples at the met gala, were they? They all went. Speaker 2: Solo boycotting, boycotting marriage on the metal, or. Speaker 1: Maybe it was like, unless that engagement wing comes from Amazon, we don't sink, perhaps in her body, her head and she did anyway. Thank you for being with us. Thank you for to our amazing team for helping us put the show together. We're going to be back in your ears on Friday, of course, and for subscribers with some scorelous gossip with Mia tomorrow. That's all. Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

OpenCameron Young tied on 18. Longest drive on 18. 365. Full pause. Birdy on 17, the hardest hole. CAl FTB: SucksFacts of life: Your Thoughts define youMiamiBeautiful and no state tax. Everyone moving there. Mansions and yachts, but lots of normal people too.  Ken Griffin.  Meta CEO Mark Zuckerberg and Priscilla Chan have purchased a $170 million, 30,000-square-foot mansion on Miami'sMarketsLong over-due correction. AI FearI've listened to a few podcasts featuring Marc Benioff in the last year. He is 100% all-in on AI. The idea that SAAS will be completed disrupted by AI is over-hyped. Jensen Huang put it well: AI will not invent a new hammer or screwdriver; they'll just use what exists. Analogy is to SaaS companies in general. Large Corporations (think Fortune 1000) are not goint to ditch big SaaS companies, like ERP (Workday, Oracle, SAP), Security, CRM, Analytics, Microsoft Office, etc... Long story, short: The AI replacement fear is over-hyped. NetflixNetflix Loses Bidding War to Paramount! Tesla & SpaceX Interview with Elon.Play at 0.28. Stop 2.00.Tesla has most advanced Real-world AI. Starting scale production of CyberCab in April.Tesla Semi coming this yearMerger SpaceX acquired XaISpaceX will go public.  SpaceX will merge with Tesla. Love this take from Travis on Autonomous driving. XAi XaI will be a financial behemothAndrej Karpathy on Elon's management styleAI OpenAI Anthropic ClaudeGovernmentNewYork CityFareed ZakariaCA FraudNick Shirley Doing his Thing again in CAWealth Taxhttps://x.com/stevenfiorillo/status/2033352518802026741According to IRS migration data, New York has lost $111 billion in net adjusted gross income over the last decade from residents moving to other states.WSJ on Billionaires leaving. Google co-founder Larry Page recently made headlines by spending $188 million on three Miami mansions.Washington State passes 9.9% tax on income over $1m. Howard Schultz leaving. Bezos already gone. Recommendations:Hims and Hers! Bill Gurley: Running down a DreamMichael Lewis: Lyar's Poker. The Rip. Was ok. The Running Man. great airplane movie. Glen Powel

This crossover episode from the Latent Space podcast features Mark Zuckerberg and Priscilla Chan on the 10-year anniversary of the Chan Zuckerberg Initiative and their expanded Biohub vision. They discuss how a “Frontier Biology Lab” working in sync with a “Frontier AI Lab” could enable breakthroughs like a Virtual Cell and true N-of-1 precision medicine. The conversation covers the acquisition of Evolutionary Scale and ESM3, new biological data collection at scale, and how AI-powered biology might transform drug discovery and disease prevention. Sponsors: Blitzy: Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com Framer: Framer is an enterprise-grade website builder that lets business teams design, launch, and optimize their.com with AI-powered wireframing, real-time collaboration, and built-in analytics. Start building for free and get 30% off a Framer Pro annual plan at https://framer.com/cognitive Serval: Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive Tasklet: Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai CHAPTERS: (00:00) About the Episode (04:27) CZI origins and focus (08:29) Why tools over cures (14:43) Virtual cells and imaging (Part 1) (20:19) Sponsors: Blitzy | Framer (23:24) Virtual cells and imaging (Part 2) (25:22) Data diversity and grounding (32:30) Evaluating models and Biohub (Part 1) (37:53) Sponsors: Serval | Tasklet (40:42) Evaluating models and Biohub (Part 2) (41:06) Future healthcare and aging (53:39) Modeling scales and immunity (58:53) Timelines, data, and collaboration (01:04:01) Outro PRODUCED BY: https://aipodcast.ing SOCIAL LINKS: Website: https://www.cognitiverevolution.ai Twitter (Podcast): https://x.com/cogrev_podcast Twitter (Nathan): https://x.com/labenz LinkedIn: https://linkedin.com/in/nathanlabenz/ Youtube: https://youtube.com/@CognitiveRevolutionPodcast Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431 Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

Frank, Ash, and Brandon spend the end of the year clearing out the Question Hole, finding brainslop, Tommy Tallarico's new alias Sammy Salazar, and the death of Sonic the Hedgehog. Hosted by Alex Jaffe, with Frank Cifaldi, Ash Parrish, and Brandon Sheffield. Edited by Esper Quinn, original music by Kurt Feldman. Watch episodes with full video on YouTube Discuss this episode in the Insert Credit Forums SHOW NOTES: “Earth friend, if you want to stay alive, turn off the computer.” Persona series The Hierophant The Tower The High Priestess The Chariot Magical Drop series Tarot WonderSwan Sega Saturn Ayami Kojima 1: MarkJ asks, what's the most inappropriate time and place for a video game merchant to set up shop? (04:02) Phantasy Star series Pokemon series Elden Ring Fantasy Zone Opa-Opa The Simpsons Resident Evil 4 Merchant Leon Kennedy Moogles Final Fantasy IX 2: Call Me By Your Name asks, which game would you play until eternity ends? (7:30) Elevator Action Returns Memento (2000) Nethack Dwarf Fortress Holedown Tetris Baldur's Gate III Pluribus 3: David asks, what would it take to make a consistently funny game? (10:36) Disco Elysium High on Life Marvel Deadpool VR Kaizo FromSoftware 4: Ryan asks, if you could be the best in the world at one video game what would it be? (12:37) Tetris California State Lottery Street Fighter series Tekken series Kimberly Elena 5: NVB asks, how would you bring back text adventure games? (13:56) Ace Attorney series Twine 6: Gallander asks, do you have any game or experience that makes you reflect on how things that once were won't ever be again, or makes you too sad? (14:58) Why Do They Call It Oven When You Of In The Cold Food Of Out Hot Eat The Food? Dragon Age: The Veilguard XCOM series Animal Crossing series Sonic 3 & Knuckles 7: Horizontal Hold asks, what video game soundtrack is most analogous in its sound as it is to its gameplay? (16:56) Tetris Effect Demonschool Rez WarioWare series Sound Shapes The Legend of Zelda 8: Billy asks, what modern non-arcade games would be improved if only available in arcades? (18:25) Beat Saber Balatro CloverPit Dogpile 9: Corey asks, what is the next phenomenon that will be predicted by a Hideo Kojima game? (19:18) Hideo Kojima Death Stranding Metal Gear Solid 2 Sammy Salazar Tommy Tallarico Mr. Snrub 10: SvenserSblant asks, how has working in the game industry impacted your ability to enjoy games? (22:20) Game Boy Advance 11: Gaagaagiins asks, what would be the for a cool run? (23:58) Tool-assisted speedrun Mega Man series The Sopranos SNK 40th Anniversary Collection Games Done Quick 12: MDS asks, if you knew better in the past, what game or console would you have been super into? (27:20) Super Nintendo Game Boy Color Commodore 64 Amiga Karateka Jordan Mechner Online Multiplayer: Two Game Blister Pack Pairing (30:36) 13: FLCL Forever asks, If Sega had nigh-unlimited money, what could they have done to save the Saturn? (32:47) Sega Saturn Xbox One PlayStation 32X Dreamcast A $5 Million Gift From Sega Saved Nvidia Sonic the Hedgehog The Murder of Sonic the Hedgehog 14: Chin asks, what do you think of violence in video games? (39:31) Spec Ops: The Line Amnesia: the Dark Descent Clock Tower 15: Dan Cantou asks is licensed crap inherently worse than original crap? (41:39) Teenage Mutant Ninja Turtles: Shredder's Revenge Terminator 2D: No Fate Indiana Jones and the Great Circle 007: First Light Fortnite Home Alone NiGHTS into Dreams… Yuji Naka 16: Malcove asks, how do we make a Studio Ghibli game? (44:37) Ni No Kuni series Giblets Boku no Natsuyasumi 17: Chopemon asks, what setting would you design for a Resident Evil-style one location video game? (45:52) Paradise Killer Promise Mascot Agency Las Vegas Strip Disneyland Crow Country Catacombs of Paris Doom Wieliczka Salt Mine Silent Hill series 18: Devilsblush asks, who is your favorite developer of video games you aren't interested in playing? (48:35) Hideo Kojima FromSoftware Elden Ring Shigeru Miyamoto 19: TapeVulture asks, how can we describe Yuji Naka's legacy? (49:39) Naoto Oshima Sonic CD Sonic the Hedgehog co-creator given suspended prison sentence for insider trading 20: Dilson asks, how could loading screens be made better? (52:43) Uncharted series Sonic Frontiers 21: Eric Hamilton Schneider asks, if you discovered a door into a video game world, what would would you be most happy is real? (54:17) The Magicians Star Trek Pokemon series Stardew Valley The Sims series 22: Garrett asks, how can or should pinball continue its evolution? (57:23) Pinball Metallica Iron Maiden 23: BreadyToDie asks, which games do time travel the best? (01:00:01) Vince Campella Titanfall 2 Effect and Cause Call of Duty series TimeSplitters Maniac Mansion: Day of the Tentacle 24: Katon asks, do you think Terry Basio could make a Donkey Konga game work? (01:02:06) Terry Bozzio Frank Zappa Donkey Konga series 25: Spencer asks, do a majority of game players have an unhealthy relationship with games? (01:03:08) Recommendations and Outro (01:04:24): Brandon: Touring After the Apocalypse, Priscilla Chan's Autumn Colors, Paradox's first album, be nice to each other Ash: Love in the Clouds Frank: Try to relax This week's Insert Credit Show is brought to you by patrons like you. Thank you. This week's horrible buzzer was sent in by selib. Thanks! To submit your own horrible buzzer, send an original recording no longer than two seconds in mp3 or wav format to show@insertcredit.com, and maybe we'll use it on the show! Subscribe: RSS, YouTube, Apple Podcasts, Spotify, and more!

Frank, Ash, and Brandon spend the end of the year clearing out the Question Hole, finding brainslop, Tommy Tallarico's new alias Sammy Salazar, and the death of Sonic the Hedgehog. Hosted by Alex Jaffe, with Frank Cifaldi, Ash Parrish, and Brandon Sheffield. Edited by Esper Quinn, original music by Kurt Feldman. Watch episodes with full video on YouTube Discuss this episode in the Insert Credit Forums SHOW NOTES: “Earth friend, if you want to stay alive, turn off the computer.” Persona series The Hierophant The Tower The High Priestess The Chariot Magical Drop series Tarot WonderSwan Sega Saturn Ayami Kojima 1: MarkJ asks, what's the most inappropriate time and place for a video game merchant to set up shop? (04:02) Phantasy Star series Pokemon series Elden Ring Fantasy Zone Opa-Opa The Simpsons Resident Evil 4 Merchant Leon Kennedy Moogles Final Fantasy IX 2: Call Me By Your Name asks, which game would you play until eternity ends? (7:30) Elevator Action Returns Memento (2000) Nethack Dwarf Fortress Holedown Tetris Baldur's Gate III Pluribus 3: David asks, what would it take to make a consistently funny game? (10:36) Disco Elysium High on Life Marvel Deadpool VR Kaizo FromSoftware 4: Ryan asks, if you could be the best in the world at one video game what would it be? (12:37) Tetris California State Lottery Street Fighter series Tekken series Kimberly Elena 5: NVB asks, how would you bring back text adventure games? (13:56) Ace Attorney series Twine 6: Gallander asks, do you have any game or experience that makes you reflect on how things that once were won't ever be again, or makes you too sad? (14:58) Why Do They Call It Oven When You Of In The Cold Food Of Out Hot Eat The Food? Dragon Age: The Veilguard XCOM series Animal Crossing series Sonic 3 & Knuckles 7: Horizontal Hold asks, what video game soundtrack is most analogous in its sound as it is to its gameplay? 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(27:20) Super Nintendo Game Boy Color Commodore 64 Amiga Karateka Jordan Mechner Online Multiplayer: Two Game Blister Pack Pairing (30:36) 13: FLCL Forever asks, If Sega had nigh-unlimited money, what could they have done to save the Saturn? (32:47) Sega Saturn Xbox One PlayStation 32X Dreamcast A $5 Million Gift From Sega Saved Nvidia Sonic the Hedgehog The Murder of Sonic the Hedgehog 14: Chin asks, what do you think of violence in video games? (39:31) Spec Ops: The Line Amnesia: the Dark Descent Clock Tower 15: Dan Cantou asks is licensed crap inherently worse than original crap? (41:39) Teenage Mutant Ninja Turtles: Shredder's Revenge Terminator 2D: No Fate Indiana Jones and the Great Circle 007: First Light Fortnite Home Alone NiGHTS into Dreams… Yuji Naka 16: Malcove asks, how do we make a Studio Ghibli game? (44:37) Ni No Kuni series Giblets Boku no Natsuyasumi 17: Chopemon asks, what setting would you design for a Resident Evil-style one location video game? (45:52) Paradise Killer Promise Mascot Agency Las Vegas Strip Disneyland Crow Country Catacombs of Paris Doom Wieliczka Salt Mine Silent Hill series 18: Devilsblush asks, who is your favorite developer of video games you aren't interested in playing? (48:35) Hideo Kojima FromSoftware Elden Ring Shigeru Miyamoto 19: TapeVulture asks, how can we describe Yuji Naka's legacy? (49:39) Naoto Oshima Sonic CD Sonic the Hedgehog co-creator given suspended prison sentence for insider trading 20: Dilson asks, how could loading screens be made better? (52:43) Uncharted series Sonic Frontiers 21: Eric Hamilton Schneider asks, if you discovered a door into a video game world, what would would you be most happy is real? (54:17) The Magicians Star Trek Pokemon series Stardew Valley The Sims series 22: Garrett asks, how can or should pinball continue its evolution? (57:23) Pinball Metallica Iron Maiden 23: BreadyToDie asks, which games do time travel the best? (01:00:01) Vince Campella Titanfall 2 Effect and Cause Call of Duty series TimeSplitters Maniac Mansion: Day of the Tentacle 24: Katon asks, do you think Terry Basio could make a Donkey Konga game work? (01:02:06) Terry Bozzio Frank Zappa Donkey Konga series 25: Spencer asks, do a majority of game players have an unhealthy relationship with games? (01:03:08) Recommendations and Outro (01:04:24): Brandon: Touring After the Apocalypse, Priscilla Chan's Autumn Colors, Paradox's first album, be nice to each other Ash: Love in the Clouds Frank: Try to relax This week's Insert Credit Show is brought to you by patrons like you. Thank you. This week's horrible buzzer was sent in by selib. Thanks! To submit your own horrible buzzer, send an original recording no longer than two seconds in mp3 or wav format to show@insertcredit.com, and maybe we'll use it on the show! Subscribe: RSS, YouTube, Apple Podcasts, Spotify, and more!

In Shawn "swyx" Wang's third appearance on the podcast, we talk about his recent interview with Mark Zuckerberg and Priscilla Chan about AI in biomedical research, and the goal to understand and eventually eradicate all diseases. We also talk about how DevRel is unbelievable back, the challenges of uphill DevRel, the dynamics of the current AI investment bubble, and the new projects he is working on.This episode is brought to you by WorkOS. If you're thinking about selling to enterprise customers, WorkOS can help you add enterprise features like Single Sign On and audit logs. Links:   •  Uphill DevRel article   •  DevRel is unbelievably back article   •  Particle/wave duality article   •  The Economics of Superstars   •  AI Engineer conference videos   •  Swyx's Linkedin

Priscilla Chan and Mark Zuckerberg join a16z's Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage. Timestamps:4:17 - Building tools to accelerate scientific discovery5:47 - The credible path to funding basic science7:21 - Biohub = Frontier Biology + Frontier AI9:05 - Challenges building on a 10-15 year timeline9:43 - How CZI chooses what to work on11:15 - Making sense of science with LLMs11:31 - Measuring success in the therapeutic realm13:32 - “Most diseases should be thought of as rare diseases”15:39 - Inspiration: building a periodic table for biology19:27 - Why virtual cells?21:17 - The Biohub Master Plan21:51 - How virtual cell models allow more risk taking28:15 - Bringing CZI & Biohub together30:32 - Why Biohub matters33:36 - The importance of interface design in democratizing scientific discovery35:34 - How Biohub encourages cross-functional collaboration40:38 - Looking ahead: the broader impact of AI on biotech Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends!Find a16z on X: https://x.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zListen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYXListen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on SpotifyListen to the a16z Podcast on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Today's guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases.Full Video EpisodeTimestamps00:00:00 Introduction and CZI's 10-Year Anniversary00:00:56 Learning from Bill Gates00:04:05 Science vs Translation00:10:45 The Power of Physical Proximity in Science00:13:55 Building the Virtual Cell: From Data to Models00:15:51 Microscopes, Imaging, and Converting Atoms to Bits00:23:18 AI Meets Biology: The Frontier Lab Concept00:27:25 How Models Can Enable More Ambitious Research00:30:15 Precision Medicine and Clinical Impact00:45:17 The Virtual Immune System and Cellular Engineering00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease00:28:45 Joining Forces with Evolutionary Scale Get full access to Latent.Space at www.latent.space/subscribe

Today's guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. Chapters 00:00:00 Introduction and CZI's 10-Year Anniversary 00:00:56 Learning from Bill Gates 00:04:05 Science vs Translation 00:10:45 The Power of Physical Proximity in Science 00:13:55 Building the Virtual Cell: From Data to Models 00:15:51 Microscopes, Imaging, and Converting Atoms to Bits 00:23:18 AI Meets Biology: The Frontier Lab Concept 00:27:25 How Models Can Enable More Ambitious Research 00:30:15 Precision Medicine and Clinical Impact 00:45:17 The Virtual Immune System and Cellular Engineering 00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease 00:28:45 Joining Forces with Evolutionary Scale

Starlink Outage, Fiverr Layoffs, and School Closure: Major Tech News Insights In this episode, host Jim Love discusses Starlink's second major global outage impacting tens of thousands of users, Fiverr's decision to lay off 30% of its workforce as it transitions to an AI-first strategy, and the closure of a primary school founded by Mark Zuckerberg and Priscilla Chan due to financial troubles. The episode highlights concerns about dependency on a single satellite service, the impact of AI on the gig economy, and the fragility of philanthropy dependent on billionaire funding. Tune in for detailed insights into these significant tech industry developments. 00:00 Introduction and Headlines 00:20 Starlink's Global Outage 01:51 Fiverr's AI Transformation 03:14 Zuckerberg's School Closure 04:47 Conclusion and Call to Action

In this special Saturday episode of What We've Been Waiting For – Unedited, host Antoinette Wolf—former corporate executive turned philanthropist, entrepreneur, licensed real estate agent, writer, and mother—dives deep into the intersections of power, philanthropy, and legacy.This extended conversation builds on last night's Hot Topics & Cool Drinks discussion, covering:Sarah Winn Williams's critique of Meta and what it teaches us about influence, trust, and culture.The Chan Zuckerberg Initiative (CZI)—how it balances innovation with philanthropy, and why it matters.The story of Dr. Priscilla Chan, whose quiet leadership reshapes health, education, and equality.The launch of The Second Act Executive, a new weekly newsletter from Wolf Vibrations LLC, created exclusively for corporate executives transitioning into their own firms, practices, or corporations. Key takeaway: Meta may be criticized as a monster on one side and a force for good on the other—but for executive parents and leaders, the real question is how we model intentional legacy for our children. Their opinions are the ones that matter most. Subscribe to The Second Act Executive at BWellnessCenter.shop.

Eric Topol (00:05):Hello, it's Eric Topol from Ground Truths, and I've got some really exciting stuff to talk to you about today. And it's about the announcement for a new Center for pediatric CRISPR Cures. And I'm delight to introduce doctors Jennifer Doudna and Priscilla Chan. And so, first let me say this is amazing to see this thing going forward. It's an outgrowth of a New England Journal paper and monumental report on CRISPR in May. [See the below post for more context]Let me introduce first, Dr. Doudna. Jennifer is the Li Ka Shing Chancellor's Chair and a Professor in the departments of chemistry and of molecular and cell biology at the University of California Berkeley. She's also the subject of this book, one of my favorite books of all time, the Code Breaker. And as you know, the 2020 Nobel Prize laureate for her work in CRISPR-Cas9 genome editing, and she founded the Innovative Genomics Institute (IGI) back 10 years ago. So Jennifer, welcome.Jennifer Doudna (01:08):Thank you, Eric. Great to be here.Eric Topol (01:10):And now Dr. Priscilla Chan, who is the co-founder of the Chan Zuckerberg Initiative (CZI) that also was started back in 2015. So here we are, a decade later, these two leaders. She is a pediatrician having trained at UCSF and is committed to the initiative which has as its mission statement, “to make it possible to cure, prevent, and manage all diseases in this century.” So today we're going to talk about a step closer to that. Welcome, Priscilla.Priscilla Chan (01:44):Thank you. Thanks for having me.Eric Topol (01:46):Alright, so I thought we'd start off by, how did you two get together? Have you known each other for over this past decade since you both got all your things going?Jennifer Doudna (01:56):Yes, we have. We've known each other for a while. And of course, I've admired the progress at the CZI on fundamental science. I was an advisor very early on and I think actually that's how we got to know each other. Right, Priscilla?Priscilla Chan (02:11):Yeah, that's right. We got to know each other then. And we've been crisscrossing paths. And I personally remember the day you won the Nobel Prize. It was in the heart of the pandemic and a lot of celebrations were happening over Zoom. And I grabbed my then 5-year-old and got onto the UCSF celebration and I was like, look, this is happening. And it was really cool for me and for my daughter.Eric Topol (02:46):Well, it's pretty remarkable convergence leading up to today's announcement, but I know Priscilla, that you've been active in this rare disease space, you've had at CZI a Rare As One Project. Maybe you could tell us a bit about that.Priscilla Chan (03:01):Yeah, so at CZI, we work on basic science research, and I think that often surprises people because they know that I'm a pediatrician. And so, they often think, oh, you must work in healthcare or healthcare delivery. And we've actually chosen very intentionally to work in basic science research. In part because my training as a pediatrician at UCSF. As you both know, UCSF is a tertiary coronary care center where we see very unusual and rare cases of pediatric presentations. And it was there where I learned how little we knew about rare diseases and diseases in general and how powerful patients were. And that research was the pipeline for hope and for new discoveries for these families that often otherwise don't have very much access to treatments or cures. They have a PDF that maybe describes what their child has. And so, I decided to invest in basic science through CZI, but always saw the power of bringing rare disease patient cohorts. One, because if you've ever met a parent of a child with rare disease, they are a force to be reckoned with. Two, they can make research so much better due to their insights as patients and patient advocates. And I think they close the distance between basic science and impact in patients. And so, we've been working on that since 2019 and has been a passion of ours.Eric Topol (04:40):Wow, that's great. Now Jennifer, this IGI that you founded a decade ago, it's doing all kinds of things that are even well beyond rare diseases. We recently spoke, I know on Ground Truths about things as diverse as editing the gut microbiome in asthma and potentially someday Alzheimer's. But here you were very much involved at IGI with the baby KJ Muldoon. Maybe you could take us through this because this is such an extraordinary advance in the whole CRISPR Cures story.Jennifer Doudna (05:18):Yes, Eric. It's a very exciting story and we're very, very proud of the teamwork that went into making it possible to cure baby KJ of his very rare disease. And in brief, the story began back in August of last year when he was born with a metabolic disorder that prevented him from digesting protein, it's called a urea cycle disorder and rare, but extremely severe. And to the point where he was in the ICU and facing a very, very difficult prognosis. And so, fortunately his clinical team at Children's Hospital of Philadelphia (CHOP) reached out to Fyodor Urnov, who is the Director of Translational Medicine at the IGI here in the Bay Area. They teamed up and realized that they could quickly diagnose that child because we had an IRB approved here at the IGI that allowed us to collect patient samples and do diagnosis. So that was done.Jennifer Doudna (06:26):We created an off-the-shelf CRISPR therapy that would be targeted to the exact mutation that caused that young boy's disease. And then we worked with the FDA in Washington to make sure that we could very safely proceed with testing of that therapy initially in the lab and then ultimately in two different animal models. And then we opened a clinical trial that allowed that boy to be enrolled with, of course his parents' approval and for him to be dosed and the result was spectacular. And in fact, he was released from the hospital recently as a happy, healthy child, gaining lots of weight and looking very chunky. So it's really exciting.Eric Topol (07:16):It's so amazing. I don't think people necessarily grasp this. This timeline [see above] that we'll post with this is just mind boggling how you could, as you said Jennifer, in about six months to go from the birth and sequencing through cell specific cultures with the genome mutations through multiple experimental models with non-human primates even, looking at off-target effects, through the multiple FDA reviews and then dosing, cumulatively three dosing to save this baby's life. It really just amazing. Now that is a template. And before we go to this new Center, I just wanted to also mention not just the timeline of compression, which is unimaginable and the partnership that you've had at IGI with I guess Danaher to help manufacture, which is just another part of the story. But also the fact that you're not just even with CRISPR 1.0 as being used in approvals previously for sickle cell and β-thalassemia, but now we're talking about base editing in vivo in the body using mRNA delivery. So maybe you could comment on that, Jennifer.Jennifer Doudna (08:38):Yeah, very good point. So yeah, we used a version of CRISPR that was created by David Liu at the Broad Institute and published and available. And so, it was possible to create that, again, targeted to the exact mutation that caused baby KJ's disease. And fortunately, there was also an off-the-shelf way to deliver it because we had access to lipid nanoparticles that were developed for other purposes including vaccinations. And the type of disease that KJ suffered from is one that is treatable by editing cells in the liver, which is where the lipid nanoparticle naturally goes. So there were definitely some serendipity here, but it was amazing how all of these pieces were available. We just had to pull them together to create this therapy.Eric Topol (09:30):Yeah, no, it is amazing. So that I think is a great substrate for starting a new Center. And so, maybe back to you Priscilla, as to what your vision was when working with Jennifer and IGI to go through with this.Priscilla Chan (09:45):I think the thing that's incredibly exciting, you mentioned that at CZI our mission is to cure, prevent, and manage all disease. And when we talked about this 10 years ago, it felt like this far off idea, but every day it seems closer and closer. And I think the part that's super exciting about this is the direct connection between the basic science that's happening in CRISPR and the molecular and down to the nucleotide understanding of these mutations and the ability to correct them. And I think many of us, our imaginations have included this possibility, but it's very exciting that it has happened with baby KJ and CHOP. And we need to be able to do the work to understand how we can treat more patients this way, how to understand the obstacles, unblock them, streamline the process, bring down the cost, so that we better understand this pathway for treatment, as well as to increasingly democratize access to this type of platform. And so, our hope is to be able to do that. Take the work and inspiration that IGI and the team at CHOP have done and continue to push forward and to look at more cases, look at more organ systems. We're going to be looking in addition to the liver, at the bone marrow and the immune system.Priscilla Chan (11:17):And to be able to really work through more of the steps so that we can bring this to more families and patients.Eric Topol (11:30):Yeah, well it's pretty remarkable because here you have incurable ultra-rare diseases. If you can help these babies, just think of what this could do in a much broader context. I mean there a lot of common diseases have their roots with some of these very rare ones. So how do you see going forward, Jennifer, as to where you UC Berkeley, Gladstone, UCSF. I'm envious of you all up there in Northern California I have to say, will pull this off. How will you get the first similar case to KJ Muldoon going forward?Jennifer Doudna (12:13):Right. Well, IGI is a joint institute, as you probably know, Eric. So we were founded 10 years ago as a joint institute between UC Berkeley and UCSF. And now we have a third campus partner, UC Davis and we have the Gladstone Institute. So we've got an extraordinary group of clinicians and researchers that are coming together for this project and the Center to make it a success. We are building a clinical team at UCSF. We have several extraordinary leaders including Jennifer Puck and Chris Dvorak, and they are both going to be involved in identifying patients that could be enrolled in this program based on their diagnosis. And we will have a clinical advisory group that will help with that as well. So we'll be vetting patients probably right after we announce this, we're going to be looking to start enrolling people who might need this type of help.Eric Topol (13:18):Do you think it's possible to go any faster right now than the six months that it took for KJ?Jennifer Doudna (13:26):I think it could be. And here's the reason. There's a very interesting possibility that because of the type of technology that we're talking about with CRISPR, which fundamentally, and you and I have talked about this previously on your other podcast. But we've talked about the fact that it's a programmable technology and that means that we can change one aspect of it, one piece of it, which is a piece of a molecule called RNA that's able to direct CRISPR to the right sequence where we want to do editing and not change anything else about it. The protein, the CRISPR protein stays the same, the delivery vehicle stays the same, everything else stays the same. And so, we're working right now with FDA to get a platform designation for CRISPR that might allow streamlining of the testing process in some cases. So it'll obviously come down to the details of the disease, but we're hopeful that in the end it will be possible. And Priscilla and I have talked about this too, that as AI continues to advance and we get more and more information about rare diseases, we'll be able to predict accurately the effects of editing. And so, in some cases in the future it may be possible to streamline the testing process even further safely.Eric Topol (14:51):And I also would note, as you both know, well this administration is really keen on genome editing and they've had a joint announcement regarding their support. And in my discussions with the FDA commissioner, this is something they are very excited about. So the timing of the new Center for pediatric CRISPR Cures is aligned with the current administration, which is good to see. It's not always the case. Now going back, Priscilla, to your point that not just for the liver because delivery has been an issue of course, and we're going to try to get after a lot of these really rare diseases, it's going to go beyond there. So this is also an exciting new dimension of the Center, as you said, to go after the bone marrow for hematopoietic cells, perhaps other organs as well.Priscilla Chan (15:42):I mean what the expertise and feasibility, the immune system is going to be the next target. Jennifer Puck has been a pioneer in this work. She's the one who designed the newborn screen that will be the tool that picks up these patients as they are born. And I think the thing that's tremendous is the immune system, first of all is active in many, many diseases, not just these cases of children born with partial or absence of immune systems. And the course right now that these babies are left with is complete isolation and then a very long and arduous course of a bone marrow transplant with high morbidity and mortality. And even if after the transplant you have complications like graft versus host and immunosuppression. And so, the idea of being able to very specifically and with less the conditioning and morbidity and mortality of the treatment, being able to address this is incredible. And the implications for other diseases like blood cancers or other hematopoietic diseases, that's incredible. And that actually has an incredibly broad base of patients that can benefit from the learnings from these babies with severe combined immunodeficiencies.Eric Topol (17:10):Yeah, I think that goes back to a point earlier maybe to amplify in that previous CRISPR generation, it required outside the body work and it was extremely laborious and time consuming and obviously added much more to the expense because of hospitalization time. This is different. This is basically doing this inside the affected patient's body. And that is one of the biggest reasons why this is a big step forward and why we're so fortunate that your Center is moving forward. Maybe before we wrap up, you might want to comment, Jennifer on how you were able to bring in to build this platform, the manufacturing arm of it, because that seems to be yet another dimension that's helpful.Jennifer Doudna (18:01):Indeed, yes. And we were again fortunate with timing because you mentioned briefly that the IGI had set up a program with the Danaher Corporation back in January of last year. We call it our Beacon project. And it's focused on rare disease. And it's a really interesting kind of a unique partnership because Danaher is a manufacturing conglomerate. So they have companies that make molecules, they make proteins, they make RNA molecules, they make delivery molecules. And so, they were excited to be involved with us because they want to be a provider of these types of therapies in the future. And they can see the future of CRISPR is very exciting. It's expanding, growing area. And so, that agreement was in place already when the baby KJ case came to our attention. And so, what we're hoping to do with Danaher is again, work with them and their scientists to continue to ask, how can we reduce the cost of these therapies by reducing the cost of the molecules that are necessary, how to make them efficiently. We already, it's very interesting, Fyodor Urnov has toured their plant in North Dakota recently, and he found in talking to their engineers, there are a number of things that we can already see will be possible to do that are going to make the process of manufacturing these molecules faster and cheaper by a lot.Eric Topol (19:28):Wow.Jennifer Doudna (19:28):So it's a win-win for everybody. And so, we're really excited to do that in the context of this new Center.Eric Topol (19:36):Oh, that's phenomenal because some of these disorders you don't have that much time to work with before they could be brain or organ or vital tissue damage. So that's great to hear that. What you built here is the significance of it can't be under emphasized, I'll say because we have this May report of baby KJ, which could have been a one-off and it could have been years before we saw another cure of an ultra-rare disorder. And what you're doing here is insurance against that. You're going to have many more cracks at this. And I think this is the excitement about having a new dedicated Center. So just in closing, maybe some remarks from you Priscilla.Priscilla Chan (20:24):I just want to emphasize one point that's really exciting as we talk about these ultra-rare cases that they're often like one in a million. All these learnings actually help maximize the impact of lots of research across the sector that impacts actually everyone's health. And so, our learnings here from these patients that have very significant presentations that really can stand to benefit from any treatment is hopefully paving the way for many, many more of us to be able to live healthier, higher quality lives through basic science.Eric Topol (21:13):And over to you, Jennifer.Jennifer Doudna (21:15):Couldn't agree more. It's a really interesting moment. I think what we hope we are, is we're at sort of an inflection point where, as I mentioned earlier, all the pieces are in place to do this kind of therapeutic and we just need a team that will focus on doing it and pulling it together. And also learning from that process so that as Priscilla just said, we are ultimately able to use the same strategy for other diseases and potentially for diseases that affect lots of people. So it's exciting.Eric Topol (21:46):For sure. Now, if I could just sum up, this is now a decade past the origination of your work of CRISPR and how already at the first decade culminated in sickle cell disease treatment and β-thalassemia. Now we're into the second decade of CRISPR. And look what we've seen, something that was unimaginable until it actually happened and was reported just a little over a month ago. Now going back to Priscilla's point, we're talking about thousands of different rare Mendelian genomic disorders, thousands of them. And if you add them all up of rare diseases, we're talking about hundreds of millions of people affected around the world. So this is a foray into something much bigger, no less the fact that some of these rare mutations are shared by common diseases and approaches. So this really big stuff, congratulations to both of you and your organizations, the Innovative Genomics Institute and the Chan Zuckerberg Initiative for taking this on. We'll be following it with very deep interest, thank you.****************************************************Thanks for listening, reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.Thanks to Scripps Research, and my producer, Jessica Nguyen, and Sinjun Balabanoff for video/audio support.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. Get full access to Ground Truths at erictopol.substack.com/subscribe

L'émission 28 minutes du 23/05/2025 Ce vendredi, Renaud Dély décrypte l'actualité en compagnie de nos clubistes : l'historien Pascal Blanchard, Sylvie Brunel, géographe et écrivaine, Nathan Devers, écrivain et philosophe et la dessinatrice de presse Coco.Proche-Orient : l'Europe prise entre deux feux ?Un match diplomatique intense s'est joué cette semaine. Face à l'opération israélienne "Chariots de Gédéon", couplée au blocus humanitaire et à la volonté d'occuper la bande de Gaza, l'Union européenne a annoncé mardi 20 mai réexaminer l'accord d'association qui la lie à Israël. La brouille diplomatique s'est rapidement amplifiée : le lendemain, des soldats israéliens ont tiré en direction de diplomates européens en déplacement dans le camp de réfugiés de Jénine, en Cisjordanie. Des tirs qui n'ont fait aucun blessé, mais qui ont provoqué une condamnation unanime de la part des chancelleries européennes. Jeudi 22 mai, deux employés de l'ambassade israélienne ont été assassinés par balle à Washington. Les condamnations de cet acte antisémite ont été nombreuses. Israël maintient toutefois son point du vue sur l'Europe et parle "d'incitation à la haine", en référence à leur durcissement diplomatique face à l'État hébreu. Des propos jugés "outranciers" par Christophe Lemoine, porte-parole du ministère des Affaires étrangères, qui témoignent de la difficulté du dialogue entre Israël et les Européens. Islamisme en France : danger réel ou fantasme ?Mardi 20 mai, "Le Figaro" a révélé un rapport très attendu sur l'influence des Frères musulmans en France. Depuis plusieurs mois déjà, le ministre de l'Intérieur Bruno Retailleau dévoilait des informations sur ce rapport qu'il juge "accablant", et s'est emparé du sujet en publiant un "Manifeste contre l'islamisme" à la fin du mois d'avril. Le rapport de 78 pages fait état de 139 lieux de culte liés à des milieux fréristes, sur les 2 600 que compte la France. Il provoque des dissensions tous azimuts, y compris sur sa méthodologie, qui divise les scientifiques, ainsi que sur sa réception et son instrumentalisation. Il a engendré de vives réactions politiques : Gabriel Attal a, par exemple, annoncé vouloir interdire le voile dans l'espace public pour les mineures de moins de 15 ans. L'islamisme en France est-il un danger ou un fantasme ? Nous recevons Plumes, un musicien atypique. Accompagné de sa très reconnaissable guitare rose, Plumes chante depuis 3 ans pour un public bien particulier : les animaux. Et ces derniers sont loin d'être insensibles aux mélodies du musicien. Le milliardaire Pierre-Édouard Stérin a esquivé pour la troisième fois sa convocation par la commission d'enquête parlementaire sur l'organisation des élections en France. Sa présence y était réclamée en raison de son engagement au profit de l'extrême droite, notamment avec le réseau "Périclès" (acronyme de Patriotes Enracinés Résistants Identitaires Chrétiens Libéraux Européens Souverainistes). Son absence a provoqué l'ire de Yaël Braun-Pivet, présidente de l'Assemblée nationale, qui l'a interpellé sur le réseau social X : "Respectez vos obligations, respectez l'Assemblée nationale et son travail de contrôle, respectez les Français".  C'est le duel de la semaine de Frédéric Says. Donald Trump ne cache pas son amour pour l'or. Il y avait eu la "gold card", présentée en avril. Place désormais au "golden dome", pour protéger les États-Unis. Un choix lexical qui reflète le goût prononcé du président américain pour ce précieux métal. C'est le Point Com de Paola Puerari. Le 21 avril, l'école pour enfants défavorisés The Primary School a annoncé qu'elle fermerait ses portes en 2026. L'établissement, situé a East Palo Alto en Californie, était l'œuvre philanthropique de Mark Zuckerberg, le richissime patron de Meta, et de sa femme Priscilla Chan. Un revirement qui intervient quelques mois après que Mark Zuckerberg s'est rangé derrière Donald Trump, et laisse 400 familles sur le carreau. C'est l'histoire de la semaine de Claude Askolovitch. Enfin, ne manquez pas la Une internationale sur l'annonce du cancer de Joe Biden ; les photos de la semaine soigneusement sélectionnées par nos invités, ainsi que la Dérive des continents de Benoît Forgeard !28 minutes est le magazine d'actualité d'ARTE, présenté par Élisabeth Quin du lundi au jeudi à 20h05. Renaud Dély est aux commandes de l'émission le vendredi et le samedi. Ce podcast est coproduit par KM et ARTE Radio. Enregistrement 23 mai 2025 Présentation Renaud Dély Production KM, ARTE Radio

Michael Bloomberg ranks as the top philanthropist in the U.S. for 2024, donating $3.7 billion to support various causes including the arts, education, public health, and city improvement. This donation marks Bloomberg's second consecutive year leading the Philanthropy 50 list. His philanthropic organization, Bloomberg Philanthropies, contributed notably with a $1 billion grant to Johns Hopkins University for medical education costs. Other major donors in 2024 include Reed Hastings and Patty Quillin, Michael and Susan Dell, Warren Buffett, Mark Zuckerberg and Priscilla Chan, and Ruth Gottesman, each donating $1 billion or more, focusing primarily on scientific research and education. Gottesman's donation aimed to make the Albert Einstein College of Medicine tuition-free. Overall, the top 50 philanthropists contributed a collective $16.2 billion, with a median donation of $100 million. Significant contributions include Thomas Golisano's $500 million to support individuals with disabilities and K. Lisa Yang's $74.5 million towards MIT and Cornell University. The Philanthropy 50 has been published for 25 years, with Warren Buffett noted as the largest individual donor at $49.4 billion. Learn more on this news visit us at: https://greyjournal.net/news/ Hosted on Acast. See acast.com/privacy for more information.

This week I am attempting to cover the natal chart of Mark Zuckerberg Bernie Sanders speech transcript https://www.sanders.senate.gov/press-releases/prepared-remarks-sanders-on-americas-dangerous-movement-toward-oligarchy-authoritarianism-kleptocracy/   Mark Zuckerberg natal Guestimate birth time 8pm (NOT accurate)      Priscilla Chan natal (accurate time and location) Scorpio Asc, Sun Pisces in 4th, Moon Aries in 5th Mark's father Edward Zuckerberg NO birth time guestimate 10pm using Whole Sign     Launches thefacebook.com Transits Facebook goes public Transits Marriage transits for Mark marrying Priscilla   Date of Testimony before U.S. Congress (also the 11th April)  

In episode 110 astrologers Kristina Martin and Tara Redfield compute our way through the synastry between billionaire social media mogul, Mark Zuckerberg and his pediatrician wife, Priscilla Chan. The two first met at a frat party at Harvard in 2003 and have been together ever since.   First, we look into Mark's chart and see a large stellium in Scorpio. With all three malefic planets, Mars, Saturn and Pluto here, it denotes a compulsive, power-hungry and intense persona. Then we look at an opposition from Venus in Taurus to Saturn and the Moon (in Scorpio) which gives us insight into his difficulty with the softer, more feminine side of life. We do see where his intellectual drive comes from...Mercury in Aries shows a person with impeccable problem-solving skills who loves a challenge.   Next, we look at Priscilla's chart and see a reserved and mysterious Scorpio rising with a high achieving, duty oriented Saturn conjunct her Ascendant.  Further in, we find an introverted and sacrificial Pisces Sun, someone who gives up a lot for others. However, we also encounter a competitive, defiant, and aggressive Mars/Venus/Moon stellium in Aries. This is one fiery woman beneath the calm waters!   Together, their synastry looks prioritized for business, with a Sun opposite Saturn, denoting responsibility, structure, and obligation. We were hard pressed to find a good amount of loving aspects, but they did share a Sun sextile Neptune aspect, highlighting Priscilla as Mark's dreamy muse, but with challenging Jupiter square to an Aries stellium, it looks like they have a lot to rage about. Listen in to hear what surprising Venus score this 20 year long marriage received!   BOOK YOUR SYNASTRY READING FOR VALENTINE'S DAY!  Connect with Kristina Martin Book a Reading www.klmastrology.com astrologyklm@gmail.com www.instagram.com/klmastrology     Connect with Tara Redfield Book a Reading www.anotherdaygreener.com anotherdaygreener@gmail.com www.instagram.com/anotherdaygreener/ www.tiktok.com/@anotherdaygreener

Get ready, #DishFam! We're dishin' on the new 'Sexiest Man Alive' reveal, spillin' tea with #PrettyVee, and diving into #DenzelWashington's shocking kiss rumor!

Mark Zuckerberg quiere traer de vuelta una tradición del Imperio Romano. El cofundador de Facebook provocó asombro en redes sociales cuando compartió el más reciente regalo que le dio a su esposa Priscilla Chan.

Introduction: Minutes 0 to 7:15 We recorded on Friday this week instead of Thursday as usual. We both loved the Olympics and talk about our favorite events and athletes.  Blake Lively and Justin Baldoni: Minutes 7:15 to 18:45 Blake Lively and Justin Baldoni are costarring in the film This Ends with Us. The book is by Colleen Hoover and it's been criticized as romanticizing domestic abuse. I've read that the movie does the same thing. Justin Baldoni is directing the film, he bought the rights and hired a screenwriter. People noticed that he skipped the London premiere and that he hasn't posed with Blake Lively or done press with her. They also noticed that Blake and the author Colleen Hoove unfollowed Justin on Instagram. The Hollywood Reporter said that Lively and Baldoni's feud started in post-production, when Blake commissioned a separate edit of the film. Chandra thinks that Justin's edit is likely the one that made it to theaters. Blake's husband Ryan Reynolds also rewrote a key scene. THR next reported that Blake screened her own edit of the film at a book event for Colleen Hoover in June. It looks like she tried to take creative control of the film. At first we got vague stories that Baldoni created a difficult work environment. The stories about why people hate him were suspicious to me. He also is said to have made Blake feel bad about her postpartum body. Baldoni has hired the same PR crisis management firm that Johnny D-pp and Brad Pitt use. TMZ then reported that Blake felt uncomfortable around Justin because he kissed her too long in a scene and because he asked her trainer how much she weighed since he had to pick her up and has a bad back. An older interview from 2016 recently came out where Blake and Parker Posey were meangirling a Norwegian interviewer, ignoring her and talking to each other instead. This is how Blake has always been.  Blake has been promoting the movie like it's a frothy romance and Justin is being serious and measured in his promotion. His production company has partnered with an anti domestic violence foundation and he has been talking about ending the cycle of abuse.  Royals: Minutes 18:45 to 25:15 None of the major royals went to the Olympics in Paris. Will and Kate just recorded a brief video congratulations with celebrities afterwards. They didn't congratulate any of the individual athletes. The Daily Mail recently reported that Kate is still undergoing preventative chemotherapy, that she's still recovering and that we probably won't see her until Remembrance Day. This is the type of story we get about Kate every six months. Earlier this month the Sussexes gave an interview to CBS Sunday Morning on behalf of their new initiative through Archewell called The Parents Network, to provide support and resources for parents to protect their children from online harm. They included parents who had lost children to online bullying and to drugs purchased online. It's a great cause. Meghan was asked about her past suicidal ideation, which she opened up about during her interview with Oprah. I play a segment from their CBS Sunday Morning interview. Harry and Meghan have been working on this cause for some time. A couple of weeks ago it was reported that the Sussexes have accepted an invitation to visit Colombia. We didn't realize it would happen so soon. Harry and Meghan are in Colombia now and the photos and videos coming out are incredible. They're so warm and natural with people. They have been meeting with the Vice President Francia Marquez, they went to a theater performance and participated in a panel about Internet safety. Marquez saw their Netflix series and that's why she wanted to meet Meghan! Politics: Minutes 25:15 to 33:30 While we were off, Kamala Harris chose Minnesota governor Tim Walz as her running mate. Chandra thinks that Harris has a soft spot for dorky white men. We loved Harris and Walz's joint video interview. We hope she does more cooking videos. We want Harris to go on Hot Ones. Trump has been having a meltdown over Harris. He called her beautiful in that lispy interview with Elon Musk and may be conflicted about her for that reason. He  hates being called weird. The Kamala HQ coms department does such a great job. Comments of the Week: Minutes 33:30 to end Chandra's comment of the week is from Agnes on the post about Brad Pitt and George Clooney covering GQ magazine. My comment of the week is from Beana on the post about Mark Zuckerberg commissioning a seven foot statue of his wife, Priscilla Chan. Thanks for listening bitches!      

Mark Zuckerberg recently unveiled a giant statue of his wife, Priscilla Chan that he gave to her as a gift...

No Labels has No Candidates and is No More | One Suit, Two Suit, Red Suit Defamation Suit Filed against Missouri Lawmakers | Wisconsin Voters Restrict Themselves | Iowa State Senate Favors Chemical Creators over Citizens | Missouri House Speaker Investigation Continues | Tennessee woman sues over abortion access | Kansas Newspaper Raid Investigation Wrapping UpSOURCES: The Missouri Independent, KMBC news, Iowa Capital Dispatch, Kansas Reflector, St Louis Post-Dispatch, and The GuardianSHOW NOTES3 Missouri State Senators Suedhttps://missouriindependent.com/2024/04/04/three-missouri-state-senators-sued-for-defamation-over-posts-about-chiefs-parade-shooting/https://www.kmbc.com/article/olathe-kansas-man-wrongly-identified-as-chiefs-parade-shooter-sues-3-missouri-lawmakers/60388311Three Missouri Republicans – including one running for statewide office – are being sued for defamation over social media posts incorrectly identifying a Kansas man as an undocumented immigrant and the shooter at the Kansas City Chiefs' Super Bowl victory celebration.On Tuesday, Denton Loudermill of Olathe, Kansas, filed federal lawsuits against state Sens. Rick Brattin of Harrisonville, Denny Hoskins of Warrensburg and Nick Schroer of Defiance. Loudermill last week filed a similar complaint against U.S. Rep. Tim Burchett of Tennessee. The four lawsuits are almost identical in their allegations against, which involve the lawmakers using social media platforms to repost a photo of Loudermill in handcuffs shortly after the shooting. “The publication of the false representation that plaintiff was an ‘illegal alien' and a ‘shooter' was not made in good faith nor was it made by defendant with any legitimate interest in making or duty to make such assertions,” the lawsuit against Brattin states. Wisconsin Voters Vote To Limit Voting… No Seriouslyhttps://www.theguardian.com/us-news/2024/apr/04/wisconsin-amendments-harmful-voting-elections?CMP=Share_iOSApp_OtherWisconsin voters enshrined in the state constitution on Tuesday two amendments that election officials and voting rights advocates worry will hurt election administration in the state.The first bans election offices from accessing private grants – a source of revenue that election officials relied on in 2020 to run elections during the pandemic and have since used to stock voting equipment in polling places.During the 2020 elections, election offices across the country – already chronically underfunded – accessed grants from the Center for Tech and Civic Life, a non-profit organization funded by Mark Zuckerberg, the Meta CEO, and his wife, Priscilla Chan. The grants were doled out with the explicit purpose of funding Covid-19 mitigation in polling places, and election offices used the money for things like personal protective equipment and to set up drive-through, contactless voting. Iowa Senate Says “Suck It Up” to folks hurt by mega corporation chemicalshttps://iowacapitaldispatch.com/2024/04/02/iowa-senate-votes-to-limit-lawsuits-over-roundup-other-farm-and-lawn-chemicals/A bill that would partially shield the maker of a widely used agricultural and lawn herbicide from lawsuits over its health effects was adopted by the Iowa Senate on Tuesday.Senate File 2412 would protect Bayer against claims it failed to warn people about the potential health effects of Roundup so long as its product is labeled as required by federal regulators.The legislation would apply to all domestic producers of herbicides and pesticides, but eliminating the failure-to-warn claims is part of Bayer's public strategy to “manage and mitigate the risks of Roundup litigation,” according to its website.The company hopes the U.S. Supreme Court decides that the claims are overruled by federal law, which the company predicts “could largely end the Roundup litigation.” But a federal appeals court rejected that argument in February.Bayer says about 167,000 lawsuits have been filed by people who claim their exposure to Roundup caused ailments such as cancer, often non-Hodgkin's lymphoma. The herbicide has been used to kill weeds for about four decades. The litigation has cost the company billions of dollars.The U.S. Environmental Protection Agency has said Roundup's primary ingredient, glyphosate, is not likely to cause cancer in humans and that it poses no health risks “when used in accordance with its current label.” But in 2015, the International Agency for Research on Cancer determined glyphosate is “probably carcinogenic to humans.”Missouri House Speaker Plocher, Now Candidate for Secretary of State, Narrows Focushttps://www.stltoday.com/news/local/government-politics/investigation-of-missouri-s-house-speaker-zeroes-in-on-lobbyist-aides-and-advisers/article_f77bc748-f203-11ee-8b90-d33ac8c58ed3.html?utm_source=dlvr.it&utm_medium=twitterAn investigation of the leader of the Missouri House appears to be focused on his efforts to steer an $800,000 state contract to a software vendor.Meeting for the seventh time since launching a probe into House Speaker Dean Plocher, the House Ethics Committee was expected to take closed-door testimony Wednesday from a handful of aides and advisers.If Plocher appears, it would mark his second time before the bipartisan panel, which has hired an investigator to conduct interviews and help prepare a report outlining any findings.Among those on the schedule is Rod Jetton, whom Plocher hired as his chief of staff last year as the scandal was unfolding. Jetton told the Post-Dispatch Wednesday he was not sure what information the committee wanted from him. Tennessee Woman Sues State Over Abortion Restrictionshttps://www.theguardian.com/us-news/2024/apr/04/tennessee-abortion-ban?CMP=Share_iOSApp_OtherJanuary 2023, whenever Kathryn Archer took her young daughter out to the local playground in Nashville, Tennessee, strangers often noticed her visibly pregnant stomach and wanted to make small talk.“When are you due?” they would ask Archer. “Do you know if you're having a boy or a girl?” “Oh, I bet your daughter's so excited to be a big sister.”Archer did not know how to tell them the truth: in early January, Archer's fetus had been diagnosed with several serious anomalies that made a miscarriage likely. If Archer did give birth, her baby could only be treated with surgeries and lifelong help – pain that Archer was unwilling to put a newborn through. Without those surgeries, which the infant might not survive, Archer's baby would die shortly after birth.But due to Tennessee's near-total abortion ban, Archer could not terminate her pregnancy in her home state and, instead, had to wait more than three weeks for an appointment at an out-of-state abortion clinic.“I don't want to confide in a stranger that I'm having to get an abortion because my baby can't survive outside of my womb and I can't get the care that I need as soon as I need it,” Archer recalled thinking. “Those three weeks were really bizarre, challenging, painful – beyond what it needed to be.”Investigation Into Marion Co. Raid That Killed Former Publisher in Kansas Is Winding Uphttps://kansasreflector.com/2024/04/02/colorado-authorities-wrapping-up-investigation-into-marion-police-who-raided-kansas-newspaper/The Colorado Bureau of Investigation is nearly finished with its inquiry into potential criminal activity surrounding the raid on the Marion County Record last year and will turn over findings to special prosecutors later this month, state authorities said Tuesday.The announcement comes a day after the Marion County Record filed a lawsuit in federal court seeking damages for alleged violations of civil rights.Melissa Underwood, a spokeswoman for the Kansas Bureau of Investigation, said Riley County Attorney Barry Wilkerson and Sedgwick County District Attorney Marc Bennett would determine whether to file criminal charges against journalists, law enforcement officers or anyone else.  @TheHeartlandPOD on Twitter and ThreadsCo-HostsAdam Sommer @Adam_Sommer85 (Twitter) @adam_sommer85 (Post)Rachel Parker @msraitchetp (Threads) Sean Diller (no social)The Heartland Collective - Sign Up Today!JOIN PATREON FOR MORE - AND JOIN OUR SOCIAL NETWORK!“Change The Conversation”Outro Song: “The World Is On Fire” by American Aquarium http://www.americanaquarium.com/

No Labels has No Candidates and is No More | One Suit, Two Suit, Red Suit Defamation Suit Filed against Missouri Lawmakers | Wisconsin Voters Restrict Themselves | Iowa State Senate Favors Chemical Creators over Citizens | Missouri House Speaker Investigation Continues | Tennessee woman sues over abortion access | Kansas Newspaper Raid Investigation Wrapping UpSOURCES: The Missouri Independent, KMBC news, Iowa Capital Dispatch, Kansas Reflector, St Louis Post-Dispatch, and The GuardianSHOW NOTES3 Missouri State Senators Suedhttps://missouriindependent.com/2024/04/04/three-missouri-state-senators-sued-for-defamation-over-posts-about-chiefs-parade-shooting/https://www.kmbc.com/article/olathe-kansas-man-wrongly-identified-as-chiefs-parade-shooter-sues-3-missouri-lawmakers/60388311Three Missouri Republicans – including one running for statewide office – are being sued for defamation over social media posts incorrectly identifying a Kansas man as an undocumented immigrant and the shooter at the Kansas City Chiefs' Super Bowl victory celebration.On Tuesday, Denton Loudermill of Olathe, Kansas, filed federal lawsuits against state Sens. Rick Brattin of Harrisonville, Denny Hoskins of Warrensburg and Nick Schroer of Defiance. Loudermill last week filed a similar complaint against U.S. Rep. Tim Burchett of Tennessee. The four lawsuits are almost identical in their allegations against, which involve the lawmakers using social media platforms to repost a photo of Loudermill in handcuffs shortly after the shooting. “The publication of the false representation that plaintiff was an ‘illegal alien' and a ‘shooter' was not made in good faith nor was it made by defendant with any legitimate interest in making or duty to make such assertions,” the lawsuit against Brattin states. Wisconsin Voters Vote To Limit Voting… No Seriouslyhttps://www.theguardian.com/us-news/2024/apr/04/wisconsin-amendments-harmful-voting-elections?CMP=Share_iOSApp_OtherWisconsin voters enshrined in the state constitution on Tuesday two amendments that election officials and voting rights advocates worry will hurt election administration in the state.The first bans election offices from accessing private grants – a source of revenue that election officials relied on in 2020 to run elections during the pandemic and have since used to stock voting equipment in polling places.During the 2020 elections, election offices across the country – already chronically underfunded – accessed grants from the Center for Tech and Civic Life, a non-profit organization funded by Mark Zuckerberg, the Meta CEO, and his wife, Priscilla Chan. The grants were doled out with the explicit purpose of funding Covid-19 mitigation in polling places, and election offices used the money for things like personal protective equipment and to set up drive-through, contactless voting. Iowa Senate Says “Suck It Up” to folks hurt by mega corporation chemicalshttps://iowacapitaldispatch.com/2024/04/02/iowa-senate-votes-to-limit-lawsuits-over-roundup-other-farm-and-lawn-chemicals/A bill that would partially shield the maker of a widely used agricultural and lawn herbicide from lawsuits over its health effects was adopted by the Iowa Senate on Tuesday.Senate File 2412 would protect Bayer against claims it failed to warn people about the potential health effects of Roundup so long as its product is labeled as required by federal regulators.The legislation would apply to all domestic producers of herbicides and pesticides, but eliminating the failure-to-warn claims is part of Bayer's public strategy to “manage and mitigate the risks of Roundup litigation,” according to its website.The company hopes the U.S. Supreme Court decides that the claims are overruled by federal law, which the company predicts “could largely end the Roundup litigation.” But a federal appeals court rejected that argument in February.Bayer says about 167,000 lawsuits have been filed by people who claim their exposure to Roundup caused ailments such as cancer, often non-Hodgkin's lymphoma. The herbicide has been used to kill weeds for about four decades. The litigation has cost the company billions of dollars.The U.S. Environmental Protection Agency has said Roundup's primary ingredient, glyphosate, is not likely to cause cancer in humans and that it poses no health risks “when used in accordance with its current label.” But in 2015, the International Agency for Research on Cancer determined glyphosate is “probably carcinogenic to humans.”Missouri House Speaker Plocher, Now Candidate for Secretary of State, Narrows Focushttps://www.stltoday.com/news/local/government-politics/investigation-of-missouri-s-house-speaker-zeroes-in-on-lobbyist-aides-and-advisers/article_f77bc748-f203-11ee-8b90-d33ac8c58ed3.html?utm_source=dlvr.it&utm_medium=twitterAn investigation of the leader of the Missouri House appears to be focused on his efforts to steer an $800,000 state contract to a software vendor.Meeting for the seventh time since launching a probe into House Speaker Dean Plocher, the House Ethics Committee was expected to take closed-door testimony Wednesday from a handful of aides and advisers.If Plocher appears, it would mark his second time before the bipartisan panel, which has hired an investigator to conduct interviews and help prepare a report outlining any findings.Among those on the schedule is Rod Jetton, whom Plocher hired as his chief of staff last year as the scandal was unfolding. Jetton told the Post-Dispatch Wednesday he was not sure what information the committee wanted from him. Tennessee Woman Sues State Over Abortion Restrictionshttps://www.theguardian.com/us-news/2024/apr/04/tennessee-abortion-ban?CMP=Share_iOSApp_OtherJanuary 2023, whenever Kathryn Archer took her young daughter out to the local playground in Nashville, Tennessee, strangers often noticed her visibly pregnant stomach and wanted to make small talk.“When are you due?” they would ask Archer. “Do you know if you're having a boy or a girl?” “Oh, I bet your daughter's so excited to be a big sister.”Archer did not know how to tell them the truth: in early January, Archer's fetus had been diagnosed with several serious anomalies that made a miscarriage likely. If Archer did give birth, her baby could only be treated with surgeries and lifelong help – pain that Archer was unwilling to put a newborn through. Without those surgeries, which the infant might not survive, Archer's baby would die shortly after birth.But due to Tennessee's near-total abortion ban, Archer could not terminate her pregnancy in her home state and, instead, had to wait more than three weeks for an appointment at an out-of-state abortion clinic.“I don't want to confide in a stranger that I'm having to get an abortion because my baby can't survive outside of my womb and I can't get the care that I need as soon as I need it,” Archer recalled thinking. “Those three weeks were really bizarre, challenging, painful – beyond what it needed to be.”Investigation Into Marion Co. Raid That Killed Former Publisher in Kansas Is Winding Uphttps://kansasreflector.com/2024/04/02/colorado-authorities-wrapping-up-investigation-into-marion-police-who-raided-kansas-newspaper/The Colorado Bureau of Investigation is nearly finished with its inquiry into potential criminal activity surrounding the raid on the Marion County Record last year and will turn over findings to special prosecutors later this month, state authorities said Tuesday.The announcement comes a day after the Marion County Record filed a lawsuit in federal court seeking damages for alleged violations of civil rights.Melissa Underwood, a spokeswoman for the Kansas Bureau of Investigation, said Riley County Attorney Barry Wilkerson and Sedgwick County District Attorney Marc Bennett would determine whether to file criminal charges against journalists, law enforcement officers or anyone else.  @TheHeartlandPOD on Twitter and ThreadsCo-HostsAdam Sommer @Adam_Sommer85 (Twitter) @adam_sommer85 (Post)Rachel Parker @msraitchetp (Threads) Sean Diller (no social)The Heartland Collective - Sign Up Today!JOIN PATREON FOR MORE - AND JOIN OUR SOCIAL NETWORK!“Change The Conversation”Outro Song: “The World Is On Fire” by American Aquarium http://www.americanaquarium.com/

In this episode of "Agents of Nonprofit," we sit down with Elenoa Fuka, a key player in the Science Philanthropy Alliance (S.P.A.), for an eye-opening discussion. Elenoa shares her unconventional path from government service, through tech, to a pivotal role in the nonprofit sector.Topics We Cover:The genesis of the Science Philanthropy Alliance, born out of a need to counter declining government funding for basic scienceInsights into the Alliance's distinctive approach, providing free advice and tailored support to philanthropists, addressing the challenges faced by newcomers and seasoned foundations alikeHear about high-profile acknowledgments from philanthropic heavyweights like Priscilla Chan and Ross BrownFrom working alone to becoming a trusted advisor to over 50 foundations and individualsThe optimistic outlook for the Alliance's future impact on shaping the philanthropic landscapeTo Learn More and Connect with Elenoa:SciPhil.orgFacebook.com/SciPhil.orgLinkedInX (Formerly Twitter)Support the show

关注公众号【Albert英语研习社】，0元报名《周一到周六 英语思维风暴营》直播大课，Albert带你巧用英语思维，轻松突破听说读写译。He's building a Zuckerbunker.Mark Zuckerberg and his wife Priscilla Chan are reportedly putting together a sprawling $270 million Hawaii compound — which covers roughly 1,400 acres and features multiple mansions — in a secret project suggesting the social media mogul is trying to conceal his doomsday preparations.Connecting the mansions will be a tunnel and a 5,000-square-foot shelter with living space, a library to pass the time, an escape hatch for quick exits and soundproof, bomb shelter-like doors made of metal and concrete. The whole place will be self-sufficient for food and water. 主播：周邦琴Albert●没有名牌大学背景，没有英语专业背景●没有国外留学经历，没有英语生活环境●22岁成为500强公司全球员工英文讲师●24岁自学成为同声传译●25岁为瑞士联邦总统翻译

In this episode, my guests are Mark Zuckerberg, CEO of Meta (formerly Facebook, Inc.), and his wife, Dr. Priscilla Chan, M.D., co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). We discuss how CZI plans to cure all human diseases by the end of this century by funding transformative projects and technologies at the intersection of biology, engineering, and artificial intelligence (AI). They describe their funding and development of CZI Biohubs and the progress already underway to accelerate the understanding of cell function, pathways, and disease. Then, Mark discusses social media, its impact on mental health, and new tools for online experiences. We also discuss Meta's virtual reality (VR), augmented and mixed reality tech, and how AI will soon completely transform our online and physical life experiences. This episode ought to interest anyone curious about biology, medicine, mental health, AI, and the future of technology and humanity. For the full show notes, including the episode transcript (available exclusively to Huberman Lab Premium members), please visit hubermanlab.com. Pre-sale password: HUBERMAN Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman The Brain Body Contract Tickets: https://www.hubermanlab.com/events Timestamps (00:00:00) Mark Zuckerberg & Dr. Priscilla Chan (00:02:15) Sponsors: Eight Sleep & LMNT; The Brain Body Contract (00:05:35) Chan Zuckerberg Initiative (CZI) & Human Disease Research (00:08:51) Innovation & Discovery, Science & Engineering (00:12:53) Funding, Building Tools & Imaging (00:17:57) Healthy vs. Diseased Cells, Human Cell Atlas & AI, Virtual Cells (00:21:59) Single Cell Methods & Disease; CELLxGENE Tool  (00:28:22) Sponsor: AG1 (00:29:53) AI & Hypothesis Generation; Long-term Projects & Collaboration (00:35:14) Large Language Models (LLMs), In Silico Experiments (00:42:11) CZI Biohubs, Chicago, New York (00:50:52) Universities & Biohubs; Therapeutics & Rare Diseases (00:57:23) Optimism; Children & Families (01:06:21) Sponsor: InsideTracker (01:07:25) Technology & Health, Positive & Negative Interactions (01:13:17) Algorithms, Clickbait News, Individual Experience (01:19:17) Parental Controls, Meta Social Media Tools & Tailoring Experience (01:24:51) Time, Usage & Technology, Parental Tools (01:28:55) Virtual Reality (VR), Mixed Reality Experiences & Smart Glasses (01:36:09) Physical Exercise & Virtual Product Development (01:44:19) Virtual Futures for Creativity & Social Interactions (01:49:31) Ray-Ban Meta Smart Glasses: Potential, Privacy & Risks (02:00:20) Visual System & Smart Glasses, Augmented Reality (02:06:42) AI Assistants & Creators, Identity Protection (02:13:26) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

The organization led by Priscilla Chan and Mark Zuckerberg will work with Columbia, Rockefeller and Yale to study immune cells.

It's October 13, 2023. Glow is back with Asian American news for kids. We have K-pop, World Dog Show, America's Got Talent, Chan Zuckerberg, and workers rights news.

It's October 13, 2023. Glow is back with Asian American news for kids. We have K-pop, World Dog Show, America's Got Talent, Chan Zuckerberg, and workers rights news.

In this week's episode of Market Mondays, we delve into a myriad of stimulating discussions encompassing the rapidly evolving realms of NFTs, tech investments, and the venture capital landscape. Here's a glimpse of the topics covered:- We kick off our conversation by exploring the provocative assertion that a staggering 95% of NFTs could be deemed worthless. How does this shape our perspective on the burgeoning NFT space?- The news of Amazon injecting up to $4 billion into Anthropic, positioning itself as a rival to ChatGPT, has piqued our interest. We debate on how this bold step might spell a brighter future for Amazon and if it holds the potential to catalyze its stock performance.- Joining us is the inspiring Arian Simone, Co-founder of the Fearless Fund. We navigate through the reverse discrimination lawsuit her venture capital firm is amidst, extracting insights on its broader implications.- The audacious vision of Priscilla Chan and Mark Zuckerberg aiming to eradicate human diseases by the century's close has captured our attention. We discuss their aspiration of creating a groundbreaking computing system to accelerate disease research, melding AI's prowess with cellular studies.- With a noticeable spate of IPO failures this year, extending from 2021, we ponder on whether the conventional VC model is hitting a wall.- Rashad reflects with a stirring monologue on how societal distractions with trivialities might be veiling our focus on larger issues at hand.- Lastly, a discernable trendline break for QQQ has emerged. We debate if this is a forewarning of turbulent times ahead for Nasdaq. #MarketMondays #TechInvestments #fearlessfund #nftSupport this podcast at — https://redcircle.com/marketmondays/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Guests: Peter Bernegger - Founder, Election Watch, explosive Wisconsin Senate Election Hearing Testimony Peter Huessy - China Expert Dynamic discussion about evidence of election interference and misappropriation of taxpayer dollars to cover party affiliated election campaign activities.  Discussed the strategic purchasing of U.S. farmland by China and the impact of the land grab around military facilities for spying by China on U.S. military and the investment by Blackrock of U.S. Pension programs for federal and state employees into China based, CCP involved companies that produce military equipment that could be used against U.S. References & Resources: CEIR - The Center for Election Innovation & Research primarily funded by Priscilla Chan & Mark Zuckerberg with what is now termed "Zuckerbucks" to influence the 2020 election.  In 2020, CEIR reported distributing $64 million in grants to fund “urgent voter education". About $62M was funded directly by Zuckerburg/Chan. Mark Zuckerberg spent $419M on nonprofits ahead of 2020 election — and got out the Dem vote https://nypost.com/2021/10/13/mark-zuckerberg-spent-419m-on-nonprofits-ahead-of-2020-election-and-got-out-the-dem-vote/ Priscilla Chan - Parents are Chinese; She went to Harvard where she met Zuckerberg. https://www.scmp.com/magazines/post-magazine/long-reads/article/3154848/yin-his-yang-priscilla-chan-opens-about-mark Definition: Theory a supposition or a system of ideas intended to explain something, especially one based on general principles independent of the thing to be explained. Definition: Conspiracy a secret plan by a group to do something unlawful or harmful. Definition: Conspiracy Theory  an attempt to explain harmful or tragic events as the result of the actions of a small group of powerful people. Sponsors: US Flag Service - Go to TheJenCharltonShow/flags to buy your flag for freedom TODAY! Sweeties on the Creek  See omnystudio.com/listener for privacy information.

In this episode, pioneering informatician Dr. Atul Butte guides listeners through his storied career, from his early days as a pediatric endocrinologist and informatician in Boston to his trailblazing work on the West Coast. Dr. Butte describes his trailblazing efforts to both harness large-scale public biomedical data and share patient data across the entire UC Health System. Dr. Butte also discusses his entrepreneurial journey, including the genesis and vision behind companies like NuMedii. Dr. Butte is the Priscilla Chan and Mark Zuckerberg Distinguished Professor at UCSF and the Chief Data Scientist of the UC Health System.   Transcript

Dr. Ehrlich is the Chief Executive Officer of the Priscilla Chan and Mark Zuckerberg San Francisco General Hospital and Trauma Center and a Professor of Medicine with the University of California, San Francisco. ZSFG is a 397-bed acute care hospital and a key part of the San Francisco Health Network and the San Francisco Department of Public Health. ZSFG is owned and operated by the City and County of San Francisco, and through its long-standing affiliation with the University of California, San Francisco, serves as a major academic teaching site, the City's only Level 1 Trauma Center, and its only 24/7 psychiatric emergency department. With its almost 6,000 DPH and UCSF staff and providers, annually ZSFG serves more than 100,000 patients, provides more than 20% of the City's inpatient care, psychiatric emergency and inpatient services, and almost 365,000 full-scope ambulatory primary and specialty care visits. ZSFG serves all San Franciscans and is focused on its most vulnerable citizens, with the vast majority of its patients on Medicaid, Medicare or uninsured. Prior to her appointment at ZSFG, Dr. Ehrlich served as the Chief Executive Officer, Chief Medical Officer, Vice President of Ambulatory Care Services, founding Medical Director of the Ron Robinson Senior Care Center and Assistant Health Officer for the San Mateo County Health System. Dr. Ehrlich also has extensive background and knowledge of public health policy and finance at all levels of government, having served as Budget and Planning Director for the San Francisco Department of Public Health and a health care analyst within the California State Legislative Analyst's Office. She is a Lean-certified physician executive with extensive expertise leading and transforming public health care organizations serving diverse and vulnerable populations. During 2019 she led ZSFG's Epic go-live and beginning in early 2020 its response to the COVID-19 pandemic. Dr. Ehrlich received her BA in Public Policy Studies from Duke University, her Master's in Public Policy from the Goldman School of Public Policy at the University of California, Berkeley, and her MD from the University of California, San Francisco. She is board certified in Internal Medicine and completed her primary care internal medicine residency at Brigham and Women's Hospital, a Harvard University-affiliated training hospital. She previously served as the Chair of the Board for the California Association of Public Hospitals, and Chair of the Board for America's Essential Hospitals. She currently is a Trustee for the California Hospital Association. She continues to practice primary care internal medicine at the Richard Fine People's Clinic on the ZSFG campus.Link to claim CME credit: https://www.surveymonkey.com/r/3DXCFW3CME credit is available for up to 3 years after the stated release dateContact CEOD@bmhcc.org if you have any questions about claiming credit.

PROFILE Mark Zuckerberg Cofounder, Meta Platforms $99.4B $292M (0.29%) Real-Time Net Worth as of 6/20/23#10 in the world today Zuckerberg started Facebook at Harvard in 2004 at the age of 19 for students to match names with photos of classmates. He took Facebook public in May 2012; he now owns about 13% of the company's stock. Facebook changed its name to Meta in November 2021 to shift the company's focus to the metaverse. In June 2021, a judge dismissed antitrust cases brought by states and the federal government, which could have forced Facebook to sell off Instagram and WhatsApp. In December 2015, Zuckerberg and his wife, Priscilla Chan, pledged to give away 99% of their Facebook stake over their lifetimes. --- Send in a voice message: https://podcasters.spotify.com/pod/show/michael-kaagee-mante/message

It's April 16, 2023. Glow is back with Asian American News for Kids. Mark Zuckerberg and Priscilla Chan Have a baby! Filipino American Jason Robertson is a NHL hotshot. Miss Universe R'Bonney Gabriel! Donald Trump has said some racist things about Elaine Chao. Seattle is the first city to ban caste desegregation.

The CZ Biohub's inspiring story began when Priscilla Chan asked Stephen Quake a seemingly impossible question: “Is it possible to cure, prevent, and manage disease in our children's lifetime?”. In 2016, the Chan Zuckerberg Initiative, founded by Priscilla and Mark Zuckerberg, set out to answer that question with a bold new mission. On the final installment of our CZ Biohub series, Priscilla and Stephen join Nate to talk about the work being done at Biohub, and how understanding human biology is the key to unlocking powerful medical treatments and cures. Through their commitment to the cause, they are showing that anything is possible. Priscilla Chan is co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. Stephen is also a professor at Stanford University. Learn more about CZ Biohub: https://www.czbiohub.org/about/#history-amp-mission Listen to more episodes from our CZ Biohub series: https://theshowaboutscience.com/2023/02/12/099-accelerating-science-to-eradicate-disease-with-priscilla-chan-and-stephen-quake/ Connect with The Show About Science:  Instagram: https://www.instagram.com/showaboutscience Facebook: https://www.facebook.com/theshowaboutscience YouTube: https://www.youtube.com/showaboutscience Twitter: https://www.twitter.com/natepodcasts LinkedIn: https://www.linkedin.com/ Loved this episode? Leave us a review and rating wherever you listen to podcasts!

Tonight, Drama, Dee, and Anand discuss one bank's demise, China's largest company, Tesla's third quarter, Zuckerberg's UFC fight, and much more. Timeline of What Was Discussed: Is Drama the Jake Paul of tennis? (1:53)  More pain for the children. (6:30)  RECESSION?! (12:48)  Evaluating how you feel about investing. (18:46)  The Tua Tagovailoa effect. (25:49)  Kweichow Moutai is CRUSHING it! (38:42)  Ignorance is bliss. (43:43)  The UFC and The Zuck. (59:32)  Lose screws and candy corn. (1:06:38)  Related Links/Products Mentioned  There are some serious rumours doing the rounds about a major bank failure  ‎Invest Like the Best with Patrick O'Shaughnessy on Apple Podcasts  Tech IPOs in 2019 Are Up 38% While Those Since 2020 Have Fallen by About as Much  Tua Tagovailoa expected to be interviewed as part of NFL-NFLPA investigation into QB's quick return from injury, sources say  China's largest company is now Kweichow Moutai - Sheel Mohnot on Twitter  Tesla delivered 343,000 vehicles in the third quarter of 2022  California Employers to Disclose Pay Ranges With Newsom Signing  Mark Zuckerberg's wife Priscilla Chan grimaces through Vegas UFC fight  Connect with Group Chat! Watch The Pod #1 Newsletter In The World For The Gram Tweet With Us Exclusive Facebook Content We're @groupchatpod on Snapchat

Russ Vought says we are in the midst of a cold civil war. And one of the reason we are so divided is that 75 million of us are facing the reality that the national security apparatus is weaponized against us and considering us domestic terrorists. He says Joe Biden needs to take the strategy of speaking less to the American people, because it just creates confusion every time he opens his mouth. The Center for Renewing America has filed two complaints with the IRS against Mark Zuckerberg, and his wife, Priscilla Chan, who donated $400 million to intervene in the 2020 election. GUEST:  RUSS VOUGHT, PRESIDENT, CENTER FOR RENEWING AMERICA 

Priscilla Chan, CEO of the Chan Zuckerberg Initiative, credits her teachers with inspiring her academic success. And so do the students at Valor College Prep, a Nashville school with a whole child approach to education supported in part by her organization. In this episode of Building Classroom Connections, from TODAY and sponsored by the Chan Zuckerberg Initiative, NBC's Morgan Radford talks to Chan about CZI's commitment to education initiatives and the importance of fostering strong student-teacher relationships. And, students and teachers tell their stories, about the kind of collaborative strategies helping them succeed together.

Walking the halls of Chicago International Charter School in the city's Bucktown neighborhood, you're likely to hear some interesting terms. Empathy interviews. Restorative justice. It's all part of the school's social emotional learning approach. But what does this teaching terminology look like in practice? In this episode of Building Classroom Connections, from TODAY and sponsored by the Chan Zuckerberg Initiative, we speak with students and educators about how SEL affects their experiences at school and outside the classroom.

Students are heading back to school across America after a challenging few years which brought major changes to their lives. One learning framework increasingly implemented in schools is called social emotional learning, or SEL. In Building Classroom Connections, from TODAY and sponsored by the Chan Zuckerberg Initiative, we dive into just what SEL looks like in practice and explore whether this framework is the future of education.

The 2020 election season, while carried out successfully by dedicated election officials and poll workers, exposed one glaring problem with the U.S. system of elections: it is chronically underfunded.Though Congress allocated $400 million for election assistance during the COVID-19 pandemic, it was far short of what experts and election administrators said was needed to pull off an election in a pandemic. Private philanthropy, from folks like Mark Zuckerberg and Priscilla Chan, stepped in to help fill the gap. These investments didn't come without scrutiny.In episode 41, Weston speaks with members of the nonprofits that distributed grants to election departments around the country in both red and blue states to set the record straight about the role private philanthropy played in the 2020 election, and the need for increased federal investment in our nation's election infrastructure.Guests:Tiana Epps-Johnson, CEO of the Center for Tech and Civic LifeSam Oliker-Friedland, Executive Director of the Institute for Responsive GovernmentThe episode also features interviews Issue One conducted with Republican election officials, including:Bill Gates, Chairman of the Board of Supervisors for Maricopa County, AZNeal Kelley, Former Registrar of Voters for Orange County, CACarly Koppes, Clerk and Recorder for Weld County, COShane Schoeller, Clerk for Greene County, MO

Dr Eric Topol sits down with Mark Zuckerberg and Priscilla Chan to talk about the next phase of their ambitious Chan Zuckerberg Initiative. This podcast is intended for US healthcare professionals only. To read a full transcript of this episode or to comment please visit: https://www.medscape.com/viewarticle/971847 CZ Biohub: https://www.czbiohub.org/ You may also like: Medscape's Chief Cardiology Correspondent Dr John M. Mandrola's This Week In Cardiology https://www.medscape.com/twic Discussions on topics at the core of cardiology and the practice of medicine with Dr Robert A. Harrington and guests on The Bob Harrington Show https://www.medscape.com/author/bob-harrington For questions or feedback, please email: news@medscape.net

Everything is so Meta! In case you missed it Facebook is now Meta, and that’s so meta. What does it mean to say meta? Meta is a prefix — a word put before another — that means after or beyond, to operate at a higher level, or change. Last night in Facebook Horizon World, I was hanging out, checking out the plaza, taking selfies, wondering who I could get to help me build my first world, and trying out the emoticons. It was kind of cool, surreal, and still very clunky and not perfect. But another $10 billion should do the trick. META and Health? Mark Zuckerberg is a hands-on dad. His wife Priscilla Chan told The Times of London that a part of his bedtime routine with his two daughters, aged 5 and 4, is coding. What will Mark and Priscilla think of FB and OG when their daughters are teenagers? What will the effects of the metaverse be on the brain? Besides All the Meta Hype: My course Modern PR Secrets is launching and is secretly available at BuyerPR.com at an insider offering of $699 - everyone tells me it is drastically low. It’s action-packed with 7 modules. One being focused on the PR avatar of the present and future as well as all my PR action-packed insights to get the most earned media possible across all channels - stop paying stupid agency fees from people that spend an hour a day writing emails and reports and annoying the journalists. Female Disruptors - I started this two years ago - it’s a magazine, a movement, and I’m dedicated to spotlighting and listing the future females. We are hosting the first Female Disruptors summit and have 15 speakers committed to sharing how they rose to the top and broke the glass ceilings. Next up in my mind and to your ear! My next course is Parents Survival Guide to Teens and Your Adults Post Pandemic - the struggle is real! 13 to 25-year-olds have been hit the hardest - parents need to be aware of what’s happening - suicide is the second-highest cause of death, and the numbers are rising - suicide ideation is a thing. We all need to open our eyes and hearts to making a change and reversing the digits. Something that is annoying me lately is what I am calling follow-up harassment - or customer service harassment. People are more sensitive, toxic and get triggered - they are on overload - we don’t need 5 reminders about a meeting, we don’t need so many text messages and if we don’t answer - it might mean we are just not having a good day, something hijacked us and we just don’t have the bandwidth to answer! Sales and marketing and customer service need to get this reminder - we are never going to pre-pandemic times - follow-up tactics, tone, frequency, and style need a makeover. Excessive and aggressive follow-ups can be intrusive and distracting. They become a blur. I get them from B2B companies after I download an ebook, my dentist, hair salon, and potential collaborators, and even cold calls. Yes, we realize you are doing your job or trying to secure a time slot and not lose business. I get it you want an answer but remember what’s happening on the other end - you never know - be sensitive, s

In this episode April Glaser is joined by co-host Meredith Broussard, a data journalism professor at NYU and author of Artificial Unintelligence: How Computers Misunderstand the World. First they talk about the history of  Silicon Valley's decades-long quest to replace teachers with computers. Then the hosts have a conversation with Nellie Bowles, tech reporter for the New York Times, about a Kansas town that's struggling with the implementation of Summit Learning, a personalized web-based education program funded by Mark Zuckerberg and his wife, Dr. Priscilla Chan. Also joining the show is Tom Henning, a parent in Kansas who pulled his son out of his local public school after Summit Learning was adopted. Henning discusses how he and other parents organized to try to bring human-centered learning back to their schools, citing the physical and emotional problems their kids came home with after being stuck in front of a computer all day. Hosted on Acast. See acast.com/privacy for more information.

In this episode April Glaser is joined by co-host Meredith Broussard, a data journalism professor at NYU and author of Artificial Unintelligence: How Computers Misunderstand the World. First they talk about the history of  Silicon Valley's decades-long quest to replace teachers with computers. Then the hosts have a conversation with Nellie Bowles, tech reporter for the New York Times, about a Kansas town that's struggling with the implementation of Summit Learning, a personalized web-based education program funded by Mark Zuckerberg and his wife, Dr. Priscilla Chan. Also joining the show is Tom Henning, a parent in Kansas who pulled his son out of his local public school after Summit Learning was adopted. Henning discusses how he and other parents organized to try to bring human-centered learning back to their schools, citing the physical and emotional problems their kids came home with after being stuck in front of a computer all day. Hosted on Acast. See acast.com/privacy for more information.