POPULARITY
3 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
2 episodes with cancer epidemiology
A recently published study by the National Cancer Institute (NCI) discovers a link between physical activity and cancer risk after gathering data from wrist sensors, which could help lead to major advances in cancer research. Alaina Shreves, predoctoral fellow at NCI's Division of Cancer Epidemiology and Genetics Metabolic Epidemiology Branch, said the findings come from accelerometer-measured physical activity, which associated low-intensity exercise with up to a 26 percent decreased risk of certain cancers. Shreves highlighted the importance of wrist sensor data in cancer prevention. She also shared her excitement about a new project involving wearable technologies to determine how walking patterns impact cancer development.
A Rebelião Saudável nasceu da união de diversos profissionais de saúde que pensam diferente e cujo foco é promover saúde e bem estar, com comida de verdade e sem medicamentos. Semanalmente a Rebelião se reune no app Telegram para discussão de tópicos importantes relacionados a Nutrição Humana e Qualidade de vida. Nessa semana, conversamos sobre Hormese. Referências citadas na transmissão: - Møller, P., Vogel, U., Pedersen, A., Dragsted, L. O., Sandström, B., & Loft, S. (2003). No effect of 600 grams fruit and vegetables per day on oxidative dna damage and repair in healthy nonsmokers. Cancer Epidemiology, Biomarkers & Prevention, 12, 1016-1022. - Peluso, I., Raguzzini, A., Catasta, G., Cammisotto, V., Perrone, A., Tomino, C., … Serafini, M. (2018). Effects of high consumption of vegetables on clinical, immunological, and antioxidant markers in subjects at risk of cardiovascular diseases. Oxidative Medicine and Cellular Longevity, 2018, 1-9. doi:10.1155/2018/5417165 - Young, J., Dragsted L.O.*, Haraldsdóttir, J., Daneshvar, B., Kall, M., Loft, S., … Sandström, B. (2002). Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. British Journal of Nutrition, 87(4), 343-355. doi:10.1079/bjnbjn2002523 - Siems WG, van Kuijk FJ, Maass R, Brenke R. Uric acid and glutathione levels during short-term whole body cold exposure. Free Radic Biol Med. 1994 Mar;16(3):299-305. doi: 10.1016/0891-5849(94)90030-2. PMID: 8063192. Ajude a rebelião saudável! Seja um apoiador do nosso movimento e garanta que as informações transmitidas continuarão gratuitas para todos! Além de ajudar, você terá acesso a um post mensal exclusivo para apoiadores! Acesse https://apoia.se/rebeliaosaudavel e contribua com a quantia que puder! Ajude a manter esse conteúdo vivo! #facapartedarebeliao Você também pode participar da discussão e da Rebelião. Toda quarta feira, às 7:00, estaremos ao vivo no Telegram, basta acessar o nosso canal: https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran.
In this episode of Walk, Don't Run to the Doctor, Miles Hassell MD focuses on cancer survivorship and prevention, emphasizing the importance of lifestyle choices. Key takeaways include: Lifestyle and Cancer: Diet, exercise, and weight management are as crucial as conventional cancer treatments like surgery or chemotherapy. Dietary Recommendations: The Mediterranean diet is highlighted for its benefits in reducing cancer recurrence, improving survival rates, and enhancing quality of life. Though the available research points to the Mediterranean diet being the most widely studied, any omnivorous, whole foods diet is practical here. Exercise & Physical Activity: Regular movement, even brief daily exercises, helps reduce cancer recurrence, boosts mood, and may improve treatment outcomes. Alcohol & Cancer: Moderate alcohol consumption may have health benefits, but overconsumption increases cancer risk. Weight Management: Maintaining a healthy weight is vital for cancer prevention and survivorship, as excess fat correlates with worse outcomes. Future Resources: A comprehensive cancer survivorship program will be available soon, with a detailed guide on managing cancer through lifestyle choices. Tune in for expert insights and practical steps to enhance cancer outcomes through lifestyle adjustments! The purpose of GreatMed.org is to enhance the doctor/patient relationship. We encourage clinicians to talk with their patients about these points, and patients to talk with their care teams. This information should not replace medical care, but enhance it. The American Cancer Society Medical and Editorial Content Team. (2023, December 15). Body Weight and Cancer Risk. The American Cancer Society. https://www.cancer.org/cancer/risk-prevention/diet-physical-activity/body-weight-and-cancer-risk.html Wang, F., et al. (2020). Adherence to dietary recommendations among long-term breast Cancer Survivors and Cancer Outcome Associations. Cancer Epidemiology, Biomarkers & Prevention, 29(2), 386–395. https://doi.org/10.1158/1055-9965.EPI-19-0872 Ergas, I. J., et al. (2021). Diet quality and breast cancer recurrence and survival: The pathways study. JNCI cancer spectrum, 5(2), pkab019. https://doi.org/10.1093/jncics/pkab019 Castro-Espin, C., et al. (2023).Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study. BMC Med 21, 225 (2023). https://doi.org/10.1186/s12916-023-02934-3 Zhang, W., et al. (2023). Adherence to healthy dietary patterns and glioma: a matched case-control study. Nutrients, 15(23), 4886. https://pubmed.ncbi.nlm.nih.gov/38068744/ Hong, S., et al. (2020). Alcohol consumption and the risk of prostate cancer: a dose-response meta-analysis. Nutrients, 12(8), 2188. https://www.mdpi.com/2072-6643/12/8/2188 Estruch, R., et al. (2022). Associations between Low to Moderate Consumption of Alcoholic Beverage Types and Health Outcomes: A Systematic Review. Alcohol and Alcoholism, 57(2), 176–184, https://doi.org/10.1093/alcalc/agab082 Buljeta, I., et al. (2023). Beneficial effects of red wine polyphenols on human health: comprehensive review. Current Issues in Molecular Biology, 45(2), 782–798. https://doi.org/10.3390/cimb45020052
In this episode, we review the high-yield topic of Cancer Epidemiology from the Oncology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
Quand Léa, auditrice de Torchon, nous a proposé de lire Kilomètre zéro de Maud Ankaoua pour un épisode du podcast, on s'attendait à de la littérature de gare, un peu feel-good, un peu romance, le truc à lire les orteils en éventails à la plage. En effet, Ankaoua truste les podiums des ventes depuis des années avec ces histoires de cadres en burnout qui se retrouvent malgré eux à entreprendre un chemin initiatique dans différents lieux aux connotations spirituelles : Kathmandu, Compostelle… On ne s'attendait donc pas à replonger si rapidement dans un bingo d'idées de développement personnel et de pseudo-sciences… Oui, certes, il y a l'histoire un peu clichée à la Eat, Pray, Love de Maëlle, une parisienne startupeuse connasse comme on aime les détester, qui découvre l'amour et le sens de la vie dans un pays lointain, et loin des idéaux occidentaux et capitalistes… Mais elle y découvre surtout un panaché d'idées qui sentent bon le new age : la loi de l'attraction, les énergies vibratoires, la médecine quantique, les thérapies alternatives pour traiter ou prévenir le cancer… Alors bon, Torchon n'est pas un podcast de reflexions scientifiques là pour debunker ce bingo de toute façon trop long, mais un humble podcast de critique littéraire. Léa et Louis s'efforcent dans cet épisode de parler fond et forme, effet de réel et topos, avec une question au coeur de leurs réflexions : comment la fiction peut-elle être un outil de persuasion pour légitimer des idées qu'on trouverait très farfelues par ailleurs ? CW : le livre, et donc l'épisode, parle de cancer, un sujet qui peut être trop lourd pour certains auditeurs. De plus, l'autrice fait référence à des théories non prouvées et non scientifiques de thérapies alternatives sur le cancer. Nous mettons en description de l'épisode plus de ressources sur le sujet. Livres cités Kilomètre zero, Maud Ankaoua, Eyrolles, 2017Respire, Maud Ankaoua, J'ai lu, 2022Plus jamais sans moi, Maud Ankaoua, Eyrolles, 2023Mars (Zorn book) par Fritz Angst, Gallimard, 2023Yoga, Emmanuel Carrère, P.O.L, 2020 La Montagne magique, Thomas Mann, 1924Interview de Maud Ankaoua dans le podcast InPower de Louise Aubery : https://open.spotify.com/episode/7yVnkBJGrBrli9t6kj1Uud?si=e2295533013b439fSite Web de Maud Ankaoua https://www.maud-ankaoua.com/Ressources : Meta de Choc, psychogénéalogie et constellations familiales https://open.spotify.com/episode/5kpQ3v8NFDz5pLyqheAku3?si=eeb275d391a044e4Le Parisien, « Bien être ou charlatanisme, enquête sur le tsunami des médecines alternatives » https://www.leparisien.fr/societe/sante/bien-etre-ou-charlatanisme-enquete-sur-le-tsunami-des-medecines-alternatives-12-02-2024-QXQJSAFHINCTXMBUQDHMHODNUI.phpEnseignement 2022-2023 : Prévention nutritionnelle des maladies chroniques : de la recherche à l'action de santé publique Séminaire du 18 avril 2023 : The Role of Nutrition and Metabolic Factors in Cancer Causation and Prevention: Lessons Learned from EPIC and Other Large Population Cohort Studies Intervenant : Elio Riboli, Professor of Cancer Epidemiology, Imperial College Londonhttps://www.youtube.com/watch?v=nY5XsQ04RwU
Debra L. Friedman, M.D., is a professor of Pediatrics in the Division of Hematology and Oncology at the Monroe Carell Jr. Children's Hospital at Vanderbilt. She is the E. Bronson Ingram Chair of Pediatric Oncology and the leader of the Cancer Control and Prevention Program and directs the Cancer Survivorship programs at the Vanderbilt-Ingram Cancer Center. Dr. Friedman's research interests lie in the long term outcomes for cancer survivors, as well as in the design of novel therapeutic protocols for childhood cancer, designed to decrease adverse long-term effects of therapy. She has leadership roles in Children's Oncology Group (COG) and is an internationally recognized expert in cancer survivorship, participating in projects evaluating best practices and models of care. She is investigating a diverse group of physiologic and psychosocial outcomes among survivors of pediatric cancer, hematopoietic stem cell transplant and medical oncology. Friedman completed her pediatric residency and a joint fellowship in Pediatric Hematology/Oncology and Cancer Epidemiology at the University of Pennsylvania and The Children's Hospital of Philadelphia (CHOP). Prior to coming to Vanderbilt in 2008, she served as the co-director of the Cancer Survivorship Program at CHOP and then, as the founder and director of the Fred Hutchinson Cancer Research Center Survivorship Program. ---- What We Do at MIB Agents: PROGRAMS: End-of-Life MISSIONS Gamer Agents Agent Writers Prayer Agents Healing Hearts - Bereaved Parent and Sibling Support Ambassador Agents - Peer Support Warrior Mail Young Adult Survivorship Support Group EDUCATION for physicians, researchers and families: OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma MIB Book: Osteosarcoma: From our Families to Yours RESEARCH: Annual MIB FACTOR Research Conference Funding multiple $100,000 and $50,000 grants annually for OS research MIB Testing & Research Directory The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter. https://www.mibagents.org Help support MIB Agents, Donate here https://give-usa.keela.co/embed/YAipuSaWxHPJP7RCJ SUBSCRIBE for all the Osteosarcoma Intel
Both long-term alcohol consumption and binge drinking can speed up biological aging, according to a Northwestern Medicine study published in the journal Aging. Lifang Hou, MD, PhD, chief of Cancer Epidemiology and Prevention in the Department of Preventive Medicine led the study and discusses the link between genetics and lifestyle in the context of preventing disease.
Join 6AMRun.com Ambassador and Host, Marc Paisant, as we welcome award-winning PhD researcher and Naturopathic Doctor, Dr. Laura Hughes To say Dr. Hughes, or Laura, is accomplished is an understatement. With degrees in Human Health/Nutrition and Epidemiology (the study and analysis of the distribution, patterns, and determinants of health and disease conditions in a defined population), a PhD in Cancer Epidemiology and Epigenetics, a Doctor of Naturopathy degree (board certified); and more than a dozen publications in international scientific journals, I think it is safe to say that she is an authority on human health. However, she heard her calling and made a change. She officially retired her Naturopathic medical license, which opened up a whole new world of global entrepreneurship and a health & wellness business that serves all of her core values. It allows her the freedom to have powerful conversations without restraint and contribute to a new paradigm of healthcare. In a nutshell, Laura truly believes that the future is rigged in our favour when we let nature inform our cells and tap into our unique energy flow and intuitive wisdom. No matter what someone's health journey or diagnoses are, these bodies that we live in are phenomenal vessels that are always working for our benefit, even if it doesn't always feel like it. There is nothing she loves more than helping listeners remember all of this and more, and then create a new story for themselves. Please visit: https://www.drlaurahughes.com/ to learn more. To be a guest, or share your story with the 6AM Run Community apply at: https://forms.gle/hBHCKpYKT6R9tH6m7 6AM Run believes in improving everyone's physical ability to not only have motion, but STAY IN MOTION. All this while creating an amazing supportive, surrounding community. Run Faster, Farther, & Recover For More Runs! Guest are found through PodPros (podmatch.com) and recorded through Riverside.fm. 6amrun.com #6amrunSee omnystudio.com/listener for privacy information.
Dr. Joni L. Rutter, Ph.D., ( https://ncats.nih.gov/director/bio ) is the Director of the National Center for Advancing Translational Sciences ( NCATS - https://ncats.nih.gov/ ) at the U.S. National Institutes of Health (NIH) where she oversees the planning and execution of the Center's complex, multifaceted programs that aim to overcome scientific and operational barriers impeding the development and delivery of new treatments and other health solutions. Under her direction, NCATS supports innovative tools and strategies to make each step in the translational process more effective and efficient, thus speeding research across a range of diseases, with a particular focus on rare diseases. By advancing the science of translation, NCATS helps turn promising research discoveries into real-world applications that improve people's health. The NCATS Strategic Plan can be found at - https://ncats.nih.gov/strategicplan In her previous role as the NCATS deputy director, Dr. Rutter collaborated with colleagues from government, academia, industry and nonprofit patient organizations to establish robust interactions with NCATS programs. Prior to joining NCATS, Dr. Rutter served as the director of scientific programs within the All of Us Research Program, where she led the scientific programmatic development and implementation efforts to build a national research cohort of at least 1 million U.S. participants to advance precision medicine. During her time at NIH, she also has led the Division of Neuroscience and Behavior at the National Institute on Drug Abuse (NIDA). In this role, she developed and coordinated research on basic and clinical neuroscience, brain and behavioral development, genetics, epigenetics, computational neuroscience, bioinformatics, and drug discovery. Dr. Rutter also coordinated the NIDA Genetics Consortium and biospecimen repository. Throughout her career, Dr. Rutter has earned an international reputation for her diverse and unique expertise via her journal publications and speaking engagements, and she has received several scientific achievement awards, including the 2022 Rare Disease Legislative Advocates–RareVoice Award for Federal Advocacy and the 2022 FedHealthIT–Women in Leadership Impact Award. Dr. Rutter received her Ph.D. from the Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, and completed a fellowship at NCI within the Division of Cancer Epidemiology and Genetics. Support the show
Supplements are all around. The general idea is that supplements are "good for us" or at least neutral. Dr. Alison Mondul walks us through why that isn't necessarily the case and how come it's so hard to get good research on them. Dr. Mondul also discusses #MiCares , a new research project that will help us understand the world around us.https://micares.health/Join Us on #theunchosenforkApple: https://apple.co/3uwyKPoSpotify: https://spoti.fi/3FuqPG4About our Guest Host:Alison Mondul, PhD, MSPH is an Associate Professor in the Department of Epidemiology at the University of Michigan School of Public Health. She completed her PhD in Cancer Epidemiology at the Johns Hopkins Bloomberg School of Public Health, her MSPH at The Emory University Rollins School of Public Health, and her BS in Microbiology at the University of Illinois at Urbana-Champaign. She is a member of the Cancer Control and Population Sciences Program at the University of Michigan Rogel Cancer Center.Dr. Mondul studies the role of modifiable risk factors in the etiology of cancer. In particular, she has studied how lifestyle factors and factors related to diet and nutrition, such as micronutrients and lipids, may influence prostate, bladder, and kidney cancers, as well as other genitourinary conditions such as benign prostatic hyperplasia, and how genetic factors may contribute to or modify these associations. More recently, she has become involved in studying head and neck cancer, which is an exciting area of inquiry as it remains an understudied cancer. Dr. Mondul is a co-investigator on the new Michigan Cancer Research and the Environment (MI-CARES) Study, which began recruitment in 2022.Support the showFollow the Unchosen Fork: Facebook Instagram TikTok Disclaimer: The contents of this podcast, including text, graphics, images, and other materials created and/or disseminated by The Unchosen Fork are for informational purposes only. The Contents are NOT intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition, before beginning a nutritional plan and/or taking nutritional supplements. Reliance on any information provided by this podcast, others content appearing on this podcast, or other visitors to the Site is solely at your own risk. None of the contents of this podcast are intended to be relied upon for medical treatment or diagnosis. The Unchosen Fork, their affiliates, nor any of the host family members assumes any liability or responsibility for damage or injury to person or property arising from any use of any product, service, information, or instruction contained on this Podcast.
Join us for a conversation about men's health as it relates to men's health awareness, men's willingness (or lack thereof) to access health care, and creating a culture where men within the minority communities are more engaged with their health. Panelists Dr. Ulysses Burley III, Chief Executive Officer/Founder UBtheCURE, LLC. Dr. Ulysses W. Burley III is the founder of UBtheCURE LLC, a consulting company on the intersection of Faith, Health, and Human Rights. A native of Houston, Texas, Ulysses studied Biology and Spanish at Morehouse College and Medicine and Public Health at Northwestern University Feinberg School of Medicine, where he went on to train in Allergy, Asthma, and Immunology. Ulysses then served as Program Director for the Evangelical Lutheran Church in America (ELCA) Strategy on HIV/AIDS, as well as Director of HIV/AIDS Programs at Heights Pharmacy. Currently, Ulysses is the Project Director for the HIV Vaccine Trials Network (HVTN) Faith Initiative to connect with diverse faith communities to share evidence-based information regarding HIV and vaccines and antibodies being developed for its prevention. Although his primary training is in Immunology and Cancer Epidemiology, Ulysses is dedicated to a vocation of social justice advocacy through faith and community-based initiatives. His main work has been around HIV and AIDS awareness, advocacy, and capacity building, but also includes LGBTQIA+, gender and racial justice, and peace in the Holy Land. He has been a guest at both the White House and United Nations for consultations on the intersections of faith and HIV/AIDS, sexual and reproductive health rights, racial justice, and global drug reform. Dr. Glen McWilliams President, Manhattan Central Medical Society National Medical Association Dr. McWilliams is Chief of Robotic Surgery at the James J. Peters Veterans Affairs Medical Center and an Assistant Clinical Professor of Urology at Columbia University and Mount Sinai School of Medicine and was named the James J. Peters VAMC Physician of the Year for 2018. He is a graduate of the Columbia University College of Physicians and Surgeons and Urology Residency Training Program. He completed a fellowship in Urologic Oncology at the National Cancer Institute and is a Lt. CDMR(ret) in the United States Public Health Service. Dr. McWilliams is an active member of the American Urological Association, the R Frank Jones Urologic Society and the Society of Urologic Oncology. Dr. McWilliams in the President of the Manhattan Central Medical Society. Dr. McWilliams has an extensive experience in the minimally invasive and robotic surgery and developed the first Robotic Surgery Program within the Veterans Integrated Systems Network 2. Dr. McWilliams is an investigator on multiple research projects involving urologic oncology and health care disparities. Originally published June 9, 2023
#deuterium #mytabolism #cancer #drquecollins #drannecooper #healthtips This week I had the most exciting opportunity! I got to chat with Dr Anne Cooper and Dr Que Collins from the center for deuterium depletion, and I was completely starstruck! If you watch the video version of our conversion on my YouTube channel, where we went deep on deuterium, metabolism, mitochondrial health and cancer, you will see I had the biggest smile. These two doctors are incredible! Dr Anne Cooper earned her Doctorate in Chiropractic from Cleveland Chiropractic College (Los Angeles), graduating with Honors. She also received a post doctoral experience in Functional Medicine and a Masters degree in Acupuncture and Traditional Chinese Medicine. And is now director at Deuterium Depletion centers. Dr Que Collins is a world leading scientist when it comes to developing and applying nutrition and metabolic therapies to treat cancer and metabolic disease in people and pets. He has a Ph.D., Clinical Immunology, a M.S. in Oncotherapeutics, a M.A. in Business and Health Policy, a B.S. is Poverty Health Care and Cancer Epidemiology and is Co-Founder and Principal Investigator for the Center for Deuterium Depletion. This is such a GREAT conversation. We hope you all enjoy it and let us know what you think in the comments. Check out Dr Coopers work at; www.mytabolism.com https://www.facebook.com/ddcenters/ https://www.instagram.com/ddcenters/?hl=en And find out more about Dr Collins here; https://bettercanceroutcomes.com/ Also Deuterium Depletion Center here; https://www.ddcenters.com/ https://www.ddcenters.com/tests/
Conversation w/ Neil Caporaso, MD, Emeritus Professor, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, about prevalence, causes, and consequences of obesity among older adults; also, medication treatments and weight loss tips.
Most adults don't realize that alcohol increases the risk of cancer, according to a new study published in the journal Cancer Epidemiology, Biomarkers and Prevention. Researchers surveyed close to 4,000 people. They asked the participants, “In your opinion how much does drinking the following types of alcohol affect the risk of getting cancer?” asking them […] The post 346. Most Americans don't realize alcohol increases the risk of cancer appeared first on Dr. David Geier - Feel and Perform Better Than Ever.
In the USA, Black and Hispanic ovarian cancer patients experience much poorer outcomes than White patients, suggesting they have less access to quality care. But why does this disparity exist, and what can be done to bridge this gap?Dr Akinyemiju, Associate Professor in Population Health Sciences at Duke University School of Medicine and Duke Cancer Institute, USA, is tackling these questions and more in the Ovarian Cancer Epidemiology, Healthcare Access, and Disparities Study, or simply, ORCHiD.Read some of their latest work here: http://dx.doi.org/10.1136/bmjopen-2021-052808
The information in this episode is a game-changer. The benefits of exercise for your physical and mental well-being are widely known, but did you know regular exercise can also reduce your risk of cancer? A recent study from Tel Aviv University has produced results that are so astounding, they made the front page of the November issue of the journal Cancer Research. (In science terms it's like getting the front page of the September issue of Vogue). The study found that aerobic exercise can reduce the risk of metastatic cancer by a whopping 72%. On this episode, Sarah explains the role of exercise both in cancer prevention and the management of cancer. Contact us: womenlikeyoupodcast@gmail.com An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination https://aacrjournals.org/cancerres/article/82/22/4164/710131/An-Exercise-Induced-Metabolic-Shield-in-Distant Exercise is proven to aid cancer treatments, so why don't patients have subsidised access to rehab? https://www.abc.net.au/news/2020-11-11/study-shows-exercise-helps-cancer-treatments/12867650 References: https://reader.elsevier.com/reader/sd/pii/S1550413117305673?token=A7DBF43852CEB793F5F668569976F7D57DCFC7C3388C07BA68F6D77851B5FB7D9D202CF646CBEDC5C6CB37635FE9797D&originRegion=us-east-1&originCreation=20221207203721 https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/physical-activity-fact-sheet Keimling M, Behrens G, Schmid D, Jochem C, Leitzmann MF. The association between physical activity and bladder cancer: systematic review and meta-analysis. British Journal of Cancer 2014; 110(7):1862-1870. [PubMed Abstract] Moore SC, Lee IM, Weiderpass E, et al. Association of leisure-time physical activity with risk of 26 types of cancer in 1.44 million adults. JAMA Internal Medicine 2016; 176(6):816-825. [PubMed Abstract] Pizot C, Boniol M, Mullie P, et al. Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies. European Journal of Cancer 2016; 52:138-154. [PubMed Abstract] Hardefeldt PJ, Penninkilampi R, Edirimanne S, Eslick GD. Physical activity and weight loss reduce the risk of breast cancer: A meta-analysis of 139 prospective and retrospective studies. Clinical Breast Cancer 2018; 18(4):e601-e612. [PubMed Abstract] Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC. Physical activity and risk of breast cancer among postmenopausal women. Archives of Internal Medicine 2010; 170(19):1758-1764. [PubMed Abstract] Fournier A, Dos Santos G, Guillas G, et al. Recent recreational physical activity and breast cancer risk in postmenopausal women in the E3N cohort. Cancer Epidemiology, Biomarkers & Prevention 2014; 23(9):1893-1902. [PubMed Abstract] Liu L, Shi Y, Li T, et al. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. British Journal of Sports Medicine 2016; 50(6):372-378. [PubMed Abstract] Schmid D, Behrens G, Keimling M, et al. A systematic review and meta-analysis of physical activity and endometrial cancer risk. European Journal of Epidemiology 2015; 30(5):397-412. [PubMed Abstract] Du M, Kraft P, Eliassen AH, et al. Physical activity and risk of endometrial adenocarcinoma in the Nurses' Health Study. International Journal of Cancer 2014; 134(11):2707-2716. [PubMed Abstract] Friedenreich C, Cust A, Lahmann PH, et al. Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition. International Journal of Cancer 2007; 121(2):347-355. [PubMed Abstract] Borch KB, Weiderpass E, Braaten T, et al. Physical activity and risk of endometrial cancer in the Norwegian Women and Cancer (NOWAC) study. International Journal of Cancer 2017; 140(8):1809-1818. [PubMed Abstract] Behrens G, Jochem C, Keimling M, et al. The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis. European Journal of Epidemiology 2014; 29(3):151-170. [PubMed Abstract] Behrens G, Leitzmann MF. The association between physical activity and renal cancer: systematic review and meta-analysis. British Journal of Cancer 2013; 108(4):798-811. [PubMed Abstract] Psaltopoulou T, Ntanasis-Stathopoulos I, Tzanninis IG, et al. Physical activity and gastric cancer risk: A systematic review and meta-analysis. Clinical Journal of Sports Medicine 2016; 26(6):445-464. [PubMed Abstract] https://english.tau.ac.il/exercise_defeats_cancer_2022 WLY newsletter subscription The Women Like You podcast is recorded on the lands of the Gadigal, Dharug and Gundungurra people. We pay our respects to elders past, present and emerging. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the land where we live, work, and exercise.See omnystudio.com/listener for privacy information.
Dr. Justin Moore is an epidemiologist with vast skills in biostatistics, epidemiology, database design, geographic information systems (GIS), mediation analysis, and cancer prevention and control. Dr. Moore serves as an assistant professor in the Cancer Prevention, Control, & Population Health Program, Department of Medicine; and the Institute of Public and Preventive Health at the Medical College of Georgia at Augusta University. Dr. Moore's research explores the intersection between race (including effects of racism) and place (social and built environment) on various health outcomes including cancer and infectious diseases. Dr. Moore's work delineated that place matters for African American, Hispanic, and rural populations characterized by hot spots of excess mortality from breast cancer, lung cancer, early-onset colorectal cancer, sepsis, and COVID-19. In this episode of A Cancer Conversation, Dr. Moore sits down with Chris Curry to discuss what a day in the life of an epidemiologist looks like, and why Dr. Moore is so passionate about making a difference in the health of people in his community. Meet Dr. Justin Xavier Moore: https://www.augusta.edu/cancer/research/cpcph/justin-moore.php
Videos: Ralph Schoellhammer: Elites Are Turning Against Their Own Civilization (23:43) Bill Clinton and Blackrock team up to ACCELERATE the great reset | Redacted with Clayton Morris Clare Daly Ireland pimped out like prostitutes for Obama (4:00) Noam Chomsky – The Crimes of U.S. Presidents (11:00) 5.Ukraine Targets Elon Musk, US Aid Dwindles, Ukraine's Offensive Increasingly Depleted (35:00) Aronia berry supplementation supports gut, arterial health King's College London, October 17 2022. The issue of Clinical Nutrition reported findings from a randomized, double-blind, placebo-controlled trial that uncovered a benefit for supplementation with aronia berry among men and women with prehypertension. “Aronia melanocarpa, or black chokeberry, has gained increased attention for its high content of (poly)phenols, and potential protection against chronic diseases such as cardiovascular disease and diabetes,” authors Melanie Le Sayec of King's College London and colleagues remarked. The trial included 102 participants between the ages of 40 and 70 years who received aronia berry extract capsules that contained 106 milligrams total polyphenols or identical placebo capsules for 12 weeks. Blood pressure, arterial function, gut microbiome composition and other factors were assessed before and after the treatment period. At the end of the study, augmentation index and pulse wave velocity, which measure arterial stiffness, significantly improved among participants who received aronia in comparison with the placebo group. The aronia-supplemented group also had a significant increase in microbiome species richness and abundance of species that produce butyrate, a compound that has a favorable effect in gut health. The researchers observed associations between plasma and urinary aronia-derived polyphenol metabolites, decreased arterial stiffness and various gut flora species. “To our knowledge, this is the first time these species are shown to correlate with beneficial effects on arterial function,” they announced. “The present findings suggest that daily consumption of aronia berry extract led to improvements in arterial function in healthy middle-aged people, with a concomitant and related increase in potentially health-promoting bacterial taxa,” the authors concluded. Zinc enhances albumin's protective role against Parkinson's disease University of Science and Technology, October 17, 2022 Revealing zinc's interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions. Heavy metals in the body have long been thought to induce the aggregation of disease-linked proteins, but a KAUST study shows this is not always the case. It turns out that zinc ions tune the ability of human serum albumin (HSA), an abundant transport protein in the body, to better prevent α-synuclein from aggregating, a process directly linked to Parkinson's disease. In unrealistically massive quantities, zinc tends to accelerate the aggregation of α-synuclein, a neuronal protein implicated in Parkinson's disease. This is what other scientists had shown in the past. But, under the types of biologically plausible experimental conditions considered by Al-Harthi, the metal actually interacts with HSA to cause the opposite effect. Using a state-of-the-art imaging technique known as proton-less nuclear magnetic resonance spectroscopy, Al-Harthi and colleagues showed that zinc binding alters the chaperone function of HSA, a multifunctional molecule that plays a role in blocking α-synuclein accretion. In particular, zinc ions biased HSA toward stronger interactions with the aggregation-prone fragments of α-synuclein, a change that blunts fibril formation and slows down the toxic process of protein deposition that can lead to neurodegeneration. High exposure to glyphosate in pregnancy could cause lower birth weights in babies Indiana University School of Medicine, October 17, 2022 Indiana University School of Medicine researchers are learning more about the effects of herbicide exposure during pregnancy, finding glyphosate in 99% of the pregnant women they observed in the Midwest. In the study, published recently in Environmental Health, higher glyphosate levels were associated with lower birth weight and may also lead to higher neonatal intensive care unit admission risk. This is the second study the researchers have conducted with significant findings. The team's previous study, published in 2018, was the first study to confirm glyphosate in 93% of pregnancies which found associations with shortened pregnancies. Other recent studies have also confirmed their findings. “Pesticide exposure in pregnancy, especially in early pregnancy, can imprint DNA and alter gene expression,” said Paul Winchester, MD, professor of clinical pediatrics and the study's lead author. Glyphosate is a chemical, commonly found in Roundup, used to kill weeds. It is used by farmers and homeowners across the United States, but especially in the Midwest on corn and soybeans. Previous studies have shown people can be exposed to glyphosate in all the foods they eat, even packaged or organic foods. “As a neonatologist, I'm seeing more and more infants with problems like low birth weight as well as mothers with issues like obesity or gestational diabetes,” Winchester said. “We need to keep studying these herbicides long term to find out how they could be causing these issues and what we can do to prevent them.” Omega-3 supplements linked to younger biological age in older people University of South Australia & University of Newcastle, October 13, 2022 Supplements of omega-3s may slow cellular ageing in older people with mild cognitive impairment, according to results of a pilot randomized clinical trial DHA (docosahexaenoic acid) was associated with reduced shortening of telomeres, DNA sequences at the end of chromosomes that shorten as cells replicate and age, report researchers from Australia in Nutrition . The aging and lifespan of normal, healthy cells are linked to the so-called telomerase shortening mechanism, which limits cells to a fixed number of divisions. During cell replication, the telomeres function by ensuring the cell's chromosomes do not fuse with each other or rearrange, which can lead to cancer. Elizabeth Blackburn, a telomere pioneer at the University of California San Francisco, likened telomeres to the ends of shoelaces, without which the lace would unravel. With each replication the telomeres shorten, and when the telomeres are totally consumed, the cells are destroyed (apoptosis). Previous studies have also reported that telomeres are highly susceptible to oxidative stress. This is not the first time that omega-3s have been linked to reduced telomere shortening, with findings from a study by researchers from the University of California, San Francisco indicating that high blood levels of omega-3 fatty acids may slow cellular ageing in people with coronary heart disease (JAMA, Vol. 303, pp. 250-257). The new study, performed by scientists from the University of South Australia, and the University of Newcastle is an intervention study, albeit on a pilot scale. Results of the study showed that the omega-6 group exhibited the greatest shortening of telomere length, compared to the DHA and EPA groups. Increased levels of DHA in red blood cells was significantly associated with reduced telomere shortening in the DHA group, said O'Callaghan and his co-workers. Reading Is Good for Your Health University of Stavanger (Norway) Oct. 8, 2022 People with poor reading skills are likely to be less healthy than those who read easily, according to recent research. Literacy skills are important for keeping in good shape. A relationship exists between self-perceived health and literacy, and draws on data from the international adult literacy and life skills survey (ALL). Self-perceived health can mean feeling pains, physical condition hampering everyday activities, fatigue, or emotional problems which affect social relationships. “Other research shows that self-perceived health is closely related to actual well-being,” explains Lundetræ. “So adults with low literacy skills, as a group, are likely to be in worse physical shape than those who can read well.” A perception of poor health increases among weak readers with age. It is greatest among those aged 45-65 and lowest in the youngest group, aged 16-24. “So it's natural that the relationship between weak reading skills and the perception of poor health rises with age. That's when you usually feel the effects of an unhealthy lifestyle or failing to look after yourself properly.” “Advice on nutrition, healthy diet and physical activity is increasingly communicated through newspaper and magazine articles and on the internet,” Lundetræ explains. “We receive a great deal of information by reading. It's conceivable that certain people miss out on important health advice because they read poorly and seldom.” How well people understand such written details could be crucial for how good they are at looking after their own health, Lundetræ observes. Health-related text is often complicated. It can contain a lot of technical terms, and is frequently badly written. That makes it difficult to grasp for poor readers. A general improvement in reading skills might accordingly give more people better health and, in the longer terms, have a beneficial effect on the cost of health services. Since a lot of those who are most in need of such knowledge are poor readers, these texts have to be easy to read. They must be written in a language which is not too technical or which uses too many words, and must communicate clearly and simply. Hair straightening chemicals associated with higher uterine cancer risk National Institutes of Health, October 17, 2022 Women who used chemical hair straightening products were at higher risk for uterine cancer compared to women who did not report using these products, according to a new study from the National Institutes of Health. The researchers found no associations with uterine cancer for other hair products that the women reported using, including hair dyes, bleach, highlights, or perms. The study data includes 33,497 U.S. women ages 35-74 participating in the Sister Study, a study led by the National Institute of Environmental Health Sciences (NIEHS), part of NIH, that seeks to identify risk factors for breast cancer and other health conditions. The women were followed for almost 11 years and during that time 378 uterine cancer cases were diagnosed. The researchers found that women who reported frequent use of hair straightening products, defined as more than four times in the previous year, were more than twice as likely to go on to develop uterine cancer compared to those who did not use the products. “We estimated that 1.64% of women who never used hair straighteners would go on to develop uterine cancer by the age of 70; but for frequent users, that risk goes up to 4.05%,” said Alexandra White, Ph.D., head of the NIEHS Environment and Cancer Epidemiology group and lead author on the new study. “This doubling rate is concerning. However, it is important to put this information into context—uterine cancer is a relatively rare type of cancer.” Uterine cancer accounts for about 3% of all new cancer cases but is the most common cancer of the female reproductive system, with 65,950 estimated new cases in 2022. Studies show that incidence rates of uterine cancer have been rising in the United States, particularly among Black women. The researchers did not collect information on brands or ingredients in the hair products the women used. However, in the paper they note that several chemicals that have been found in straighteners (such as parabens, bisphenol A, metals, and formaldehyde) could be contributing to the increased uterine cancer risk observed. Chemical exposure from hair product use, especially straighteners, could be more concerning than other personal care products due to increased absorption through the scalp which may be exacerbated by burns and lesions caused by straighteners.
Videos : The world's worst financial thief (10:30) Oh No, something BIG is happening in Germany, the WEF is make it worse| Redacted with Clayton Morris (11:45) Ukraine Targets Elon Musk, US Aid Dwindles, Ukraine's Offensive Increasingly Depleted (35:00) Research identifies the herbal supplements that are effective in treating anxiety Global Neuroscience Initiative Foundation, October 6, 2022 A systematic review of research into the use of nutritional supplements for the treatment of anxiety disorders has found strong evidence for the use of extracts of passionflower or kava and combinations of L-lysine and L-arginine. Researchers writing in open access Nutrition Journal pooled the results of 24 studies involving a total of more than 2000 participants, showing that some nutritional and herbal supplements can be effective, without the risk of serious side effects. The research was carried out by Shaheen Lakhan and Karen Vieira from the Global Neuroscience Initiative Foundation, a non-profit charity organization for the advancement of neurological and mental health patient welfare, education, and research, based in Los Angeles, USA. Lakhan said, “Our review and summary of the literature on herbal remedies and dietary supplements for anxiety should aid mental health practitioners in advising their patients and provide insight for future research in this field. We found mixed results – while passionflower or kava and L-lysine and L-arginine appeared to be effective, St John's Wort and magnesium supplements were not”. Of the studies included in the review, 21 were randomized controlled trials. Of these, 15 showed positive effects from either a nutritional or herbal remedy and any reported side effects were mild to moderate. Melatonin improves mitochondrial function in rat model of diabetes University of Granada, La Paz University Hospital & University of Texas, October 6 2022. The Journal of Pineal Research published an article by researchers that reported a protective effect for melatonin on mitochondrial function in obese rats. “Mitochondrial dysfunction in adipose tissue may contribute to obesity-related metabolic derangements such as type 2 diabetes mellitus,” write principle investigator Ahmad Agil and colleagues. “Because mitochondria are a target for melatonin action, the goal of this study was to investigate the effects of melatonin on mitochondrial function in white and beige inguinal adipose tissue of Zücker diabetic fatty rats. The team divided eight diabetic rats and eight lean littermates to receive melatonin-enhanced or plain drinking water for six weeks, after which mitochondrial function was evaluated. They observed improvement in mitochondrial respiration, and a reduction in oxidative status among both lean and obese animals that received melatonin. He observed that, along with other factors, the rise in obesity in both developed and developing countries has coincided with exposure to artificial light at night, which inhibits the body's production of melatonin. The inhibition of melatonin production that occurs when a lamp, computer or television is left on leads to disrupted sleep and an increased risk of weight gain, which negatively impacts the mitochondria, promoting insulin resistance and diabetes. “For all these reasons, it is important to try to sleep in absolute darkness, to avoid interference in the generation of melatonin,” Professor Agil noted. Walking can reduce breast cancer risk American Cancer Society, October 4, 2022 Postmenopausal women who were very active or walked for at least seven hours a week had a reduced risk for breast cancer, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Women who engaged in at least an hour of vigorous physical activity every day had a 25 percent lower risk for breast cancer, and those who walked for at least seven hours a week had a 14 percent lower risk for breast cancer, in this study of 73,615 postmenopausal women. “We examined whether recreational physical activity, specifically walking, was associated with lower breast cancer risk. Given that more than 60 percent of women report some daily walking, promoting walking as a healthy leisure-time activity could be an effective strategy for increasing physical activity among postmenopausal women,” said Alpa Patel, Ph.D., senior epidemiologist at the American Cancer Society (ACS) in Atlanta, G. “We were pleased to find that without any other recreational activity, just walking an average of one hour per day was associated with lower risk of breast cancer in these women.” “Current guidelines recommend that adults should strive to get at least 2.5 hours per week of moderate-intensity activity, or 75 minutes per week of vigorous-intensity aerobic activity for overall health. Higher levels of activity may provide greater benefit for breast cancer prevention,” said Patel. Patel and colleagues identified 73,615 postmenopausal women from a large cohort of 97,785 women aged 50 to 74 years. All participants provided information on the average number of hours they spent on various physical activities including walking, jogging, swimming, playing tennis, bicycling, and performing aerobic exercises every week, and the number of hours spent in leisure time sitting, including watching television and reading. The researchers calculated the total hours of metabolic equivalent (MET) per week for each participant, which is a ratio of the energy spent during a specific activity to the resting metabolic rate. The researchers found that about 9.2 percent of the participants did not partake in any physical activity, and about 47 percent of them reported walking as their only activity. The median MET expenditure among active women was 9.5 MET hours per week, which translates to 3.5 hours of moderately-paced walking. They found that the most active women with 42 MET hours per week or more (at least one hour of vigorous activity every day) had a 25 percent lower risk for breast cancer compared with women who were least active, with less than seven MET hours per week (e.g., moderately-paced walking for two hours a week). Among women who reported walking as their only activity, those who walked for seven hours or more per week had a 14 percent lower risk for breast cancer, compared with those who walked for three hours or less. Selenium may help fight pre-cancer cervical condition Arak University of Medical Sciences (Iran) , October 10, 2022 Long-term consumption of selenium supplements may help reverse the progression of the ‘pre-cancer' condition cervical intraepithelial neoplasia grade 1 (CIN1), say researchers in Iran. Published in the British Journal of Nutrition, the study saw 58 women diagnosed with this low-grade CIN given either a placebo tablet or 200 micrograms of selenium supplements as selenium yeast daily for six months. After six months of supplementation they saw a regression in the condition and other beneficial metabolic effects. This included significant decreases in fasting plasma glucose levels, serum insulin levels and serum TAG levels and increased HDL-cholesterol levels. Cervical intra-epithelial neoplasia (CIN) is a term used to describe changes in the squamous cells of the cervix. CIN is not a cancer but if left untreated may develop into cancer and is therefore often described as a ‘pre-cancerous condition' by doctors. However if left untreated, the risk of progression to invasive cervical carcinoma was about 30–50%. The results from this latest research found significant rises in total plasma antioxidant capacity in the supplemented group compared with the placebo. There was also a significant decrease in malondialdehyde, a marker of oxidative stress. X-rays raise childhood leukemia risk University of California at Berkeley, Oct 5, 2022 A new study by researchers at the University of California has revealed that diagnostic X-rays may increase the risk of developing childhood leukemia. Specifically, the researchers found that children with acute lymphoid leukemia (ALL) had almost twice the chance of having been exposed to three or more X-rays compared with children who did not have leukemia. For B-cell ALL, even one X-ray was enough to moderately increase the risk. The findings come from the Northern California Childhood Leukemia Study, a population-based case-control study that includes 35 counties in the northern and central regions of the state. The study included 827 children up to age 15 diagnosed with either ALL or AML. The children with leukemia were each compared with other children randomly selected from the California birth registry who were matched by factors such as age, gender, ethnicity and maternal race. The study found an increased risk from X-rays for ALL, but not for AML or T-cell leukemia, and there was no association with age at first exposure. Furthermore, there was no increased risk associated with prenatal exposure to X-rays or maternal X-rays occurring before pregnancy. Surfing can prevent suicidal feelings in combat veterans with PTSD Loughborough University (UK) October 11, 2022 Surfing can help improve well-being in combat veterans experiencing post-traumatic stress disorder and even avert suicidal feelings, according to a Loughborough University researcher. Nick Caddick said some of the veterans from Northern Ireland, Iraq and Afghanistan, who took part in his study, revealed that surfing had not only improved their health and quality of life but saved their lives. It is the first time research has been conducted into a ‘Blue Gym' – the sea – therapy that is becoming increasingly popular in Britain and America and is being seen as an alternative to the traditional medical option which can involve drugs. It is estimated that 6.9 per cent of UK combat soldiers will go on to suffer significant distress as a result of their service. Nick said: “A number of veterans said they would most likely not be around if it wasn't for experiencing surfing in the ‘Blue Gym' environment. For the men, being active in this environment was an excellent example of ‘exercise is medicine' Nick spent time with them, both in and out of the water, observing how surfing gave them respite from PTSD symptoms like nightmares, flashbacks, severe depression, anxiety, and suicidal thoughts. Nick stressed that surfing was not a cure, and that the veterans expected to live with PTSD for the rest of their lives. But he said his research suggested that, if undertaken regularly, surfing was a powerful alternative to medical treatments which the veterans were sceptical about. “The veterans referred to it as a tremendous sense of freedom. It takes them completely away from the traumatic thoughts that spin through their minds all day long. Most of them don't believe they will be cured, but it gives them something important to look forward to, which stops them dwelling on all the bad stuff.
Some important milestones have passed during the pandemic blur of the last few years. The 50th anniversary of the National Institute for Occupational Safety and Health (NIOSH) was one. Created by the Occupational Safety and Health (OSH) Act of 1970. NIOSH, one of the Centers for Disease Control and Prevention (CDC), was established as a “separate and independent research program to create objective scientific research findings in the field of occupational safety and health.” Today's episode of Stats+Stories with guest Dr. Paul Schulte Dr. Paul Schulte was the Director of the Division of Science Integration and Co-Manager of the Nanotechnology Research Center at the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC). He currently is a consultant with Advanced Technologies and Laboratories International, Inc. Dr. Schulte has 47 years of experience in conducting and developing guidance on occupational cancer, nanomaterials, risk communication, workplace well-being, and genetics. He also has examined the convergence of occupational safety and health and green chemistry and sustainability. He is the co-editor of the textbook, Molecular Epidemiology: Principles and Practices. Dr. Schulte has served as guest editor of the Journal of Occupational Medicine and the American Journal of Industrial Medicine and was on the initial editorial board of Cancer Epidemiology, Biomarkers and Prevention. He is currently on the International Advisory Board of the Annals of Occupational Hygiene. Dr. Schulte has developed various frameworks for addressing the aging workforce, burden of occupational disease and injury, well-being of the workforce, and translation research and synthetic biology and occupational risk.
Videos: 1. What Do We Do With Useless People? - Yuval Harari 2. $26.000.000 For Lying About The Test Being in nature: Good for mind, body and nutrition Researchers from Drexel University investigated how feeling connected with the natural world benefits dietary diversity and fruit and vegetable intake. Drexel University, April 25, 2022 In late 2020, Canadian doctors made headlines for “prescribing nature,” or recommended time outdoors based on research that suggests people who spent two or more hours in nature per week improved their health and wellbeing. Knowing this, transdisciplinary researchers from Drexel University investigated how nature relatedness – simply feeling connected with the natural world – benefits dietary diversity and fruit and vegetable intake, in a study recently published the American Journal of Health Promotion. “Nature relatedness has been associated with better cognitive, psychological and physical health and greater levels of environmental stewardship. Our findings extend this list of benefits to include dietary intake,” said Brandy-Joe Milliron, PhD, at Drexel's College of Nursing and Health Professions and lead author of the publication. “We found people with higher nature relatedness were more likely to report healthful dietary intake, including greater dietary variety and higher fruit and vegetable consumption.” The research team surveyed over 300 adults in Philadelphia to measure their self-reported connection to nature, including their experience with and perspective of nature, and the foods and beverages they had consumed the previous day to assess their dietary diversity and estimate their daily fruit and vegetable consumption. (NEXT) Overnight fasting may reduce breast cancer risk in women University of California at San Diego, April 20, 2022 A decrease in the amount of time spent eating and an increase in overnight fasting reduces glucose levels and may reduce the risk of breast cancer among women, report University of California, San Diego School of Medicine researchers in the journal Cancer Epidemiology, Biomarkers & Prevention. "Increasing the duration of overnight fasting could be a novel strategy to reduce the risk of developing breast cancer. This is a simple dietary change that we believe most women can understand and adopt. It may have a big impact on public health without requiring complicated counting of calories or nutrients." Women who fasted for longer periods of time overnight had significantly better control over blood glucose concentrations. The data shows that each three hour increase in nighttime fasting was associated with a 4 percent lower postprandial glucose level, regardless of how much women ate. Women in the study reported eating five times per day with a mean nighttime fasting of 12 hours. Those who reported longer fast durations also indicated they consumed fewer calories per day, ate fewer calories after 10 p.m. and had fewer eating episodes. (NEXT) Micronutrients (vitamins + minerals) show benefit for children with ADHD and emotional dysregulation Evidence from a randomized clinical trial shows broad-spectrum micronutrient supplementation with all known vitamins and essential minerals resulted in global improvement of attention and mood based on blinded clinician ratings Oregon Health & Science University, April 26, 2022 A study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) reports that children with ADHD and emotional regulation randomized to take a micronutrient formula were three times more likely to show symptomatic improvement on blinded clinician ratings, compared to those in the placebo group (54% versus 18%). The micronutrient formula, consisting of all known vitamins and essential minerals, was administered for eight weeks. (NEXT) Raspberry, a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias University of Guadajara (Mexico), 11 April 2022 Raspberry production and consumption have increased in recent years due to its polyphenol content such as anthocyanins and ketones, bioactive compounds that have been studied to reduce blood glucose levels and stabilize the blood lipid profile. Original articles from in vitro and in vivo enzyme inhibition studies, animal models, and human clinical studies were compiled in PubMed, Web of Science, and Science Direct databases. Studies showed satisfactory results regarding blood glucose level reduction after consumption of frozen or lyophilized raspberry, infusion of raspberry leaves, seed oil, as well as compounds, extracted from the fruit by inhibiting enzymes such as α-glucosidase and dipeptidyl peptidase-4 (DPP-4) and other mechanisms that increase insulin production and insulin sensitivity. A reduction in cholesterol and low-density lipoprotein levels is reported, as well as an increase in high-density lipoproteins. A According to the results, raspberry can be included in the nonpharmacological treatment of hyperglycemia and dyslipidemias; however, further research is considered necessary.
Bringing together the debate on gender and advances in knowledge about sex biases in human genetics.A conversation with Prof Gareth Evans, Professor of Medical Genetics and Cancer Epidemiology at The University of Manchester, Reubs J Walsh, a PhD Candidate in the Department of Clinical, Neuro- and Developmental Psychology at the Vrije Universiteit Amsterdam, and Dr Can Ding, Vice Chair of the ESHG Young Geneticists Committee (ESHG-Y).
In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with first author, Sachelly Julián-Serrano and leader author, Rachael Z Stolzenberg-Solomon, of the recently published AJCN manuscript “Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies”. In this episode, we dive into genetic epidemiology approaches, iron metabolism, and the risk of PDAC with our 2 guest authors from the Division of Cancer Epidemiology and Genetics at the National Cancer Institute.Be sure to connect with us on twitter ( Sachelly Julián-Serrano: @sachellyjs; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.
Our featured audio this episode is titled Cancer Epidemiology, created by graduate student Pranoti Pradhan. This audio is a subset of a larger production called Going Viral, Basics of Epidemiology, produced by Saimrunali Dadigala. Discover how the field of cancer epidemiology sprung to life with three notable observations as Pranoti takes us back to ancient Egypt, walks us through history, and directs our gaze towards the future. Side effects of listening to this audio may include blasts from the past, increased knowledge, and desires to learn more. Here's a dose of Cancer Epidemiology by Pranoti Pradhan.
Two of the most important issues in administering a medication are the right patient and the right drug. Correct medications must be strictly given to the right patient and doctors must ensure that the medications given are up to date and as prescribed to prevent drug errors. Not all medications work for everyone so it is crucial to diagnose the patient correctly to prescribe the correct medicine for them. This is why healthcare is rapidly moving towards precision medicine. Precision medicine, also known as personalized medicine, is at its core for matching the right drug for the right patient. It offers a greater understanding of diseases and finds the intervention and treatment that best suits the patient's needs by focusing on their genetics, environment, and lifestyle. Some studies show that many diseases are linked to genetic mutations thus, genes play a big role in how a certain disease starts.As we talk about the future of medicine, Dr. Dung Trinh is joined by the Principal Investigator of the All of Us Research Program, Dr. Hoda Anton-Culver, to share how their program works and how it focuses on collaborating with populations who are traditionally underrepresented in biomedical research. To shape the future of medicine, they welcome everyone to participate in this study regardless of culture, gender, and nationality.Participating in research like this is a great opportunity not only for your benefit but could also shape the future of medicine for the next generation. Click the play button and learn more about what this research is all about! Memorable Quotes:“We are looking for any single condition, and characteristic that's why we have availability to huge data.” - Dr. Hoda Anton-Culver“Not everyone responds to a medication the same way.” - Dr. Hoda Anton-Culver“We cannot treat every patient with the same cookie cutter.” - Dr. Dung TrinhOther Resources:https://allofus.health.uci.edu/Important Points:Everyone is welcome to participate in the All of Us Research ProgramThe scope of the All of Us program covers different topics such as diet, health, family history of the disease, environmental factors, and more.The program doesn't target testing for a particular disease but focuses on genetic information, lifestyle activities, and nutrition.About the Guests:Hoda Anton-Culver, Ph.D., is the principal investigator of All of Us Research Program, the founding director of Genetic Epidemiology Research Institute, and a professor in the Department of Medicine School of Medicine, UCI Health. Her research interests include Precision Medicine, Cancer Epidemiology, Genetic Epidemiology, Disease Prevention, and Translational Epidemiology.About the Host:Dung Trinh, MD is the Chief Medical Officer of Irvine Clinical Research, medical missionary with TongueOut Medical Missions, and holds leadership positions with multiple health care organizations in Orange County. He is a keynote speaker, best-selling author, and Host of “Health Talks with Dr. Trinh” which can be heard weekly on OC Talk Radio.Connect with Dr. TrinhHealthTalks OC WebsiteLinkedIn
In this exciting episode, our very special guest is the wonderful Javacia Harris Bowser, an award-winning freelance journalist, columnist, and essayist and the founder of See Jane Write — a website and community for women who write and blog. Her writing focuses on women's issues, wealth and wellness. In this episode, we discuss Javacias experience with beating breast cancer at 38, and how to win at freelancing. Javacia transitioned from a 10-year career in teaching to her full-time, See Jane Write. According to a study that was recently published in Cancer Epidemiology, Biomarkers, & Prevention, a journal of the American Association for Cancer Research, "while breast cancer mortality rates have declined over the last few decades, Black women are still twice as likely to die from breast cancer compared to other ethnicities". This is according to the results of a study led by Robert Hines, associate professor of population health sciences at the College of Medicine. Javacia discussed the importance of good health care for Black and minority women and how she uses her voice to advocate through partners like the Tigerlily Foundation. After her diagnosis, Javacia also changed her lifestyle and her transition to freelancing also helped her cope with the demands of her cancer treatment schedule and needs, which took place during the COVID-19 pandemic. Tune in to listen in to this exciting episode of the Holistic Wealth Podcast with special guest, Javacica Harris Bowser. --- Support this podcast: https://anchor.fm/keisha-blair/support
Dr. Lindsay Morton of the National Cancer Institute at the National Institutes of Health reflects on research findings by Øvlisen et al that leverage large-scale linked registries in Denmark to suggest that improvements in both chemotherapy treatments and assisted reproductive technologies have made it possible for more survivors of Hodgkin lymphoma to become parents. TRANSCRIPT This JCO podcast provides observations and commentary on the JCO article “Rates and Use of Assisted Reproduction Techniques in Younger Hodgkin Lymphoma Survivors: A Danish Population-Based Study of 793 Patients and 3965 Matched Comparators” by Øvlisen and colleagues. My name is Lindsay Morton, and I am a Senior Investigator and Deputy Chief of the Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, at the Intramural Research Program of the National Cancer Institute at the National Institutes of Health. I am trained in epidemiology, and my oncologic specialty is in hematologic malignancies and cancer survivorship research. I have no relevant conflicts to disclose. The adverse effects of treatment among patients with Hodgkin lymphoma have long been at the forefront of oncology research. In the late 1960s, patients with Hodgkin lymphoma were some of the first to receive combination chemotherapy with a four-drug regimen called “MOPP,” consisting of mechlorethamine, vincristine, procarbazine, and prednisone. MOPP resulted in dramatic improvements in patient outcomes following diagnosis with Hodgkin lymphoma. But in subsequent decades, the toxicities of MOPP came to be understood, including both acute toxicities – most notably myelosuppression – as well as longer-term toxicities such as second cancers and sterility, especially in males. Around the same timeframe, long-term toxicities of radiotherapy also were increasingly recognized, which set off a search for effective Hodgkin lymphoma treatment approaches with fewer short- and long-term toxicities. I often think of how research on adverse effects in patients with Hodgkin lymphoma has been at the vanguard in cancer survivorship: this focus has helped to drive development of new therapies and changes in clinical practice. This has occurred in part because Hodgkin lymphoma is frequently diagnosed in early adulthood and patients now have such a good prognosis; this means there is a longer window in which to experience any long-term effects of cancer treatments, and patients face unique issues, such as impacts on fertility, which aren't relevant for older cancer patients. In the paper accompanying this podcast, Øvlisen and colleagues present novel data on parenthood rates and use of assisted reproduction techniques in Danish patients with Hodgkin lymphoma. Importantly, the results of this study are very relevant to current patients because all the patients in the study were treated between 2000 and 2015 using standard treatment approaches that are still frequently used today. About one-third of the study population received radiotherapy plus 2-4 cycles of the combination chemotherapy regimen called “ABVD,” which consists of doxorubicin, bleomycin, vinblastine, and dacarbazine, and is the preferred front-line therapy approach for Hodgkin lymphoma patients in the United States. Another third of the study population received 6-8 cycles of ABVD, while in the remaining third, about half received either “BEACOPP” (a seven-drug regimen, which includes bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone, and which is commonly used in Europe) or some other chemotherapy regimen. In this study, the authors compared the rates of parenthood in patients with Hodgkin lymphoma to individuals in the general population who were matched to the patients by age, sex, and parenthood status. Overall, the news was good: both male and female survivors of Hodgkin lymphoma had similar parenthood rates as the matched individuals from the general population. But the details of this bigger picture finding are really worth understanding because of their important impact on patients. In particular, a larger number of patients with Hodgkin lymphoma than the comparison individuals from the general population used assisted reproductive technology in order to become parents. Specifically, nearly 22% of male and 14% of female survivors of Hodgkin lymphoma used assisted reproductive technology compared with only about 6% of those in the general population. When the authors looked at various predictors of parenthood in subgroup analyses, one other finding stood out: male survivors of Hodgkin lymphoma who had received BEACOPP therapy had about half the rate of parenthood compared with other Hodgkin lymphoma survivors and the general population. In contrast, for female survivors, parenthood rates were similar among the different treatment groups, but the numbers of female survivors treated with BEACOPP was small, so we should be cautious about drawing conclusions for females. The results from Øvlisen and colleagues seem to reflect two important changes from previous studies, most of which included patients who were treated with older chemotherapy regimens, like MOPP. First, Hodgkin lymphoma treatments have continued to evolve, and adverse effects on fertility seem to be declining for the newer regimens. Second, of course, there also have been important advances in assisted reproductive technology, so that individuals who have trouble with conception initially can be helped by these technological advances. In addition to hearing this good news for patients with Hodgkin lymphoma, the way the authors collected the information for this study was also exciting because it was large-scale, long-term, and systematic. Most of the data on fertility in patients with Hodgkin lymphoma previously has come from clinical trials. Those data have been invaluable, and in fact, provided some of the first signs several decades ago that patients with Hodgkin lymphoma treated with MOPP could face fertility issues. But we also know that clinical trials often have incomplete information on outcomes that occur more than a few years out, which raises some questions about the validity or generalizability of the study results for those outcomes. In this report, the authors collected information on patients with Hodgkin lymphoma and the matched individuals from the general population from nationwide birth and patient registries. In countries like the United States, this study design would be virtually impossible because our healthcare system is fragmented – patients receive different types of care, like their cancer treatment and fertility treatments, in different places, and there is no easy way to link information on these different types of care for a specific individual. In this Danish study, the authors were able to leverage the centralized nature of the healthcare system in Denmark to capture not only all the information on the Hodgkin lymphoma treatments but also the birth registries and use of assisted reproductive techniques – connecting this information from different sources for all the individuals in the study. Because of the linkages that are possible among all these different sources of data, we are confident that the study provides complete, unbiased information even on longer-term outcomes. While this study demonstrates both the importance of long-term patient follow-up and the power of registries, it also highlights the need to continue efforts to reduce toxicities and improve outcomes in patients with Hodgkin lymphoma, particularly those diagnosed in childhood, adolescence, or young adulthood. Fertility is just one aspect of quality of life that may be impacted by cancer treatment, and the more high-quality data we bring to bear on cancer survivorship, the better we will be at not just treating cancer but also taking care of the whole patient for the many years they have ahead of them. This concludes this JCO Podcast. Thank you for listening.
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: June Chan, ScD and Stacey Kenfield, ScD, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37265]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: June Chan, ScD and Stacey Kenfield, ScD, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37265]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: June Chan, ScD and Stacey Kenfield, ScD, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37265]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: June Chan, ScD and Stacey Kenfield, ScD, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37265]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: June Chan, ScD and Stacey Kenfield, ScD, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37265]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
The California Prostate Cancer Coalition (CPCC) and The Helen Family Diller Comprehensive Cancer Center present the 2021 Patient Conference on Prostate Cancer. This session: Matt Cooperberg, MD, MPH, UCSF. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 37256]
Returning guest, Dr. Andrew Chan, MD, MPH, Gastroenterologist, Chief, Clinical and Translational Epidemiology Unit, Director of Cancer Epidemiology, Massachusetts General Cancer Center discusses his recent research "Associations Between Screening Lower Endoscopy and Colorectal Cancer Incidence in Younger Adults", which was recently presented at the 2021 Digestive Disease Week annual scientific meeting. Andrew T. Chan, M.D., M.P.H. is a Professor of Medicine at Harvard Medical School (HMS), Chief of the Clinical and Translational Epidemiology Unit, and the Program Director for gastroenterology training at Massachusetts General Hospital (MGH). As a clinical gastroenterologist, Dr. Chan specializes in familial gastrointestinal cancer syndromes and cancer prevention. #DDW21 #LowerEndoscopy #ColorectalCancer
Paul Han, MD, MA, MPH is Senior Scientist in the Division of Cancer Control and Population Sciences and Adjunct Investigator in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute. Dr. Han's research focuses on understanding and improving the communication and management of uncertainty in health care. His clinical background is in […] The post Uncertainty: What It Is and Ways to Help (HLOL #213) appeared first on Health Literacy Out Loud Podcast.
By popular request, here’s an episode reviewing some common benign dermatological conditions. We won’t hit every disease, but we will review some key diseases and concepts that are commonly tested on boards. Feel free to follow along with your review book or Google images to ingrain the images associated with each disease. For a review of malignant dermatology, check out S1E16 on Cancer Epidemiology, where we address the different types of skin cancer!
Conversation between Pranoti and Saimrunali, where they discuss cancer health disparities in epidemiology research and practice.
Let's learn about cancer epidemiology, the history behind it, and how it has helped us improve the identification and assessment of risk factors!
Nur Zeinomar, PhD is a cancer epidemiologist who is an Instructor of Medicine in the Section of Cancer Epidemiology and Health Outcomes at Rutgers Cancer Institute of New Jersey. She and I talk about how it does take a village to raise kids with two parents with demanding careers, and how she found that village in New York City. She also wanted to talk about her need for safe spaces to express her religion and culture, and her ultimate acceptance of her own unique qualities a Muslim Arab American. Nur tells me about her life as the default parent, her love of Syrian cooking, her "resting nice face", and much more!
Pancreatic Cancer Epidemiology
Dr Kristi Milley spoke to Professor Yoryos Lyratzopoulos and Dr Monica Koo from University College London. Yoryos is Professor of Cancer Healthcare Epidemiology and leads the Epidemiology of Cancer Healthcare and Outcomes (ECHO) group and Monica is a post-doctoral research associate in the ECHO group. They recently published a paper ‘The prevalence of chronic conditions in patients diagnosed with one of 29 common and rarer cancers: A cross-sectional study using primary care data’ in the journal Cancer Epidemiology. Yoryos and Monica highlight that pre-existing morbidities influence the diagnosis and management of cancer and that the prevalence of specific morbidities in patients diagnosed with common and rarer cancers is not adequately described.They want listeners to be reminded of the interplay between chronic conditions and cancer, and to keep these realities in mind so they can be guided through prevention and more holistic management of patients once they present and are diagnosed with cancer.
This episode covers cancer epidemiology!
Inside-Out Leadership: Human Leadership and Mental Health with Dr. Alison Van Dyke Dr. Alison Van Dyke joined the Data Quality, Analysis, and Interpretation Branch of the Surveillance Research Program (SRP) as Director of the SEER-linked Virtual Tissue Repository (VTR) Pilot Studies. For the VTR Pilot Studies, SRP works with SEER registries to obtain custom annotations of detailed treatment data for pancreas and female breast cancer cases which may have biospecimens available. The goal is to match unusual survival cases with more typical survival controls. Dr. Van Dyke also directs the Residual Tissue Repositories (RTRs). Operated by the SEER registries in Hawaii, Iowa, and Los Angeles, the RTRs collect tissue being discarded by hospital laboratories once the minimum requirement for retaining diagnostic tissue blocks, as set forth by the College of American Pathologists (CAP), has been met.Prior to joining SRP, Dr. Van Dyke earned her MD/PhD from Wayne State University School of Medicine in 2011 with graduate training in cancer biology. Under the mentorship of Dr. Ann Schwartz, her doctoral research focused on the role of inflammation in non-small cell lung cancer among women and included SEER data. She completed postgraduate medical residency training in anatomic pathology at Yale-New Haven Hospital and surgical subspecialty training in thoracic pathology at the University of Pittsburgh Medical Center. In addition to being board certified in Anatomic Pathology by the American Board of Pathology, she is a Fellow of the CAP and serves as the SEER Liaison to the CAP Cancer Committee, which determines what and how tumor information will be reported in pathology reports.Dr. Van Dyke completed a postdoctoral fellowship in the Infections and Immunoepidemiology Branch of the Division of Cancer Epidemiology & Genetics (DCEG). Working with Drs. Jill Koshiol and Eric Engels in DCEG, Dr. Van Dyke's postdoctoral research focused on the incorporation of surgical pathology in epidemiologic research. She utilized data from the NCI Cancer Cohort Consortium to investigate the epidemiology of biliary tract cancers. She was also the first researcher to use the digital slide collection from the National Lung Screening Trial to investigate the relationships between lung scarring characteristics and lung cancer development. In addition, she established pathology tissue collection and evaluation methods for Dr. Koshiol’s Chile Biliary Longitudinal Study (Chile BiLS). She is completing a NAACCR project examining biliary tract cancer incidence trends in the United States.In this episode we discuss her path to being a MD/PhD, some of the projects she is working on currently at the NCI, the lessons she learned from living with Bipolar Disorder, and her experience as a woman in STEM. Questions we posed include: What it means to you to be a physician-scientist and why you chose this path? How does balancing these two professional identities affect your leadership philosophy? What things outside of medical school, research, and residency have you done that most impacted your leadership development? What are some Challenges/barriers that you faced? Why do you still think there is still such a stigma surrounding mental health? What needs to be emphasized during the training of young medical and scientific leaders in order to improve the culture? Do you have any personal stories where you felt that you were discriminated against by your peers for your gender?What message do you want to send to our listeners that may feel discriminated against based on their gender, race, etc? What are your favorite books? What advice do you have for medical trainees?
In this episode, Dr. Anthony Miller speaks on The Body of Evidence Linking Cell Phone and Wireless to Cancer at the Wireless Technology Forum in Michigan in 2018 Dr. Anthony Miller is a physician and epidemiologist. He is currently Professor Emeritus at the Dalla Lana School of Public Health at the University of Toronto. He has served as Director of the Epidemiology Unit of the National Cancer Institute of Canada, the Chair of the Department of Preventive Medicine and Biostatistics at the University of Toronto, Senior Epidemiologist at the International Agency for Research on Cancer, and Head of the Division of Cancer Epidemiology at the German Cancer Research Centre, 2000-03; Dr. Miller is also a consultant to the Division of Cancer Prevention for the U.S. National Cancer Institute and for the World Health Organization. He has published hundreds of studies on environmental health. In this conference, Dr. Miller lays out the evidence which connects wireless radiation––from cell phones, cell towers, and wifi routers––to cancer.
Epidemiology Counts from the Society for Epidemiologic Research
Sleep is essential for wellbeing and overall health. We spend up to a third of our lives asleep and the general state of “sleep health” is an important question throughout our lifespan. The CDC has estimated that 1 in 3 American Adults do not achieve the recommendation of at least 7 hours of sleep each night for adults aged 18–60 years. Inadequate sleep has been associated with an increased risk of developing chronic conditions such as cancer, obesity, diabetes, high blood pressure, heart disease, stroke, and dementia. Bryan James and Rachael Stolzenberg-Solomon host a discussion with Neil Caporaso, a Senior Investigator in the Occupational and Environmental Epidemiology Branch, in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute about the epidemiology and science of sleep and health.
4:23 - Motivation Behind Becoming A Doctor 9:50 - Perks of Using Social Media to Your Advantage As A Health Professional 15:10 - Shy away from identifying information and criticizing online as a healthcare worker 17:35 - 21:36 How to express your personal opinion on social media as a professional 21:56 - separate the issue from the person through empathy 26:51 - What it takes to prepare for med school 32:01 - How to effectively research information and identify credible sources Sajjad Fazel is an internationally recognized public health professional with 5+ years of experience working in health policy, research, health promotion, management, communications, and knowledge translation. Currently, Sajjad works as a research associate in the Cancer Epidemiology and Prevention Research Department at Alberta Health Services. He is also the research director for Knight's Cabin – an NGO assisting cancer survivors to adopt a healthy lifestyle. Sajjad's research focuses on three main areas; health promotion and misinformation, cancer prevention, and tobacco control. Prior to joining Alberta Health Services, Sajjad was a policy researcher for the Canadian Cancer Society where he led the smoke-free campuses initiative. Devoted to science communication, Sajjad created the Afya Yako program – a health promotion initiative that improved the health literacy of over 100,000 Tanzanians. He has been featured in major news outlets including BBC, CBC, IBN, Radio Deutsche Welle, Voice of America, and Global News Radio. In 2019, Sajjad was voted among the top 50 most influential Tanzanians. Sajjad is interested in the intersection of health, policy and media. He is currently working with a team of researchers across Canada studying Covid-19 misinformation. Find us on all streaming platforms : Spotify, Apple Music, Google Play, Stitcher https://www.2ndfloorpodcast.com For any bookings, business or collaborations E-mail - thesecondfloorpod@gmail.com
While many think of epidemiology as indicative of infectious disease, it actually designates the study of patterns of disease. Amanda Phipps explains this and her research into colorectal cancer. She discusses How a cancer epidemiologist begins to approach colorectal cancer, What types of samples they are able to find and what types of patterns they are looking for, and How microbiomes factor into their studies and what may be significant. Amanda Phipps is Associate Professor of Epidemiology and the Associate Chair of Epidemiology at the University of Washington. She explains that cancer epidemiology entails asking what puts some people at risk, why do some people develop certain kinds of cancer like breast cancer while others don't develop any or develop different kinds. Further, among those who do develop cancer, what predicts a good prognoses versus bad? She remarks that researchers try and get very specific about their subsets of study. Even with the same type of cancer like breast or colorectal cancer, each cancer is very different. There are different sets of genetic changes, risk factors, and courses of treatment. She discusses her research into colorectal cancer and the effort to gather as much data about their subjects as possible to identify certain patterns. She is also looking at the microbiomes from the tissue samples of these patients, comparing cancerous and noncancerous tissues. She explains their methodology and tests they perform, including the DDR PCR test, as well as a bacterium they've identified that seems to show a significant pattern in relation to colorectal cancer. She also touches on some other studies and future interests including immunotherapy responses and investigating associations between sleep apnea and certain cancers. To find out more, see her faculty web page: https://epi.washington.edu/faculty/phipps-amanda Available on Apple Podcasts: apple.co/2Os0myK
Today, on the top fitness podcast, I interview Dr. Sajjad Fazel. Dr. Sajjad Fazel is a public health researcher in the Cancer Epidemiology and Prevention Research Department at Alberta Health Services. He is also the research director for Knight's Cabin – an NGO assisting cancer survivors to adopt a healthy lifestyle. His research focuses on three main areas; health promotion and misinformation, cancer prevention, and tobacco control. Sajjad is currently working with a team of researchers across Canada studying Covid-19 misinformation. He has been featured in major news outlets including BBC, CBC, Voice of America and Global News Radio. Sajjad holds a Doctor of Pharmacy degree from Manipal University, India and a Master of Public Health from Western University, Canada. This was a great episode asking how to systematically determine what information you should consume and how to alleviate fear and anxiety around this uncertain time. HERE'S THE FIRST QUESTION TO ASK: Is this information true! Far too often, people believe, share and get impacted by information that isn't event factual- and this is becoming a huge problem- especially for mental health around COVID and with minimizing the spread of the disease. To find out more about Dr. Fazel and his work, you can find him on LinkedIn Are you feeling stuck in Quarantine with the COVID -15 or just feel out control and just don't know how to start practicing self care through this unprecedented time? If you answered yes, then join us for five weeks to regain your vibrant self through exercise, nourishing foods and shifting your mindset, at https://catherinetanaka.com/projectyou Subscribe Apple | Google | iHeart Partners Four Sigmatic: boost your overall wellness and immune function easily with functional mushrooms. Use Four Sigmatic's Mushroom coffee Mix for incredible gut health but the best morning java you could get! GO TO: https://foursigmatic.com and use code BODYPROJECT to get your discount today! Age Quencher: Looking for an incredible way to supplement your health and fitness goals? Use Age Quenchers REJUVENATE for incredible lactose-free, whey protein for supporting lean muscle mass, and use the HYDRATE electrolyte to support your hydration and therefore your fat flushing potential! Save 15% with CODE: FIT www.agequencher.com
Welcome to Health Your Own Way Weekly Podcast!Host: Mo.AkinsI upload new episodes every Friday and video recording of each episode is available on YouTube!Today's episode we will be discussing the Impact of Social Media On The Global Healthcare System with my special guest Dr. Sajjad Fazell.Dr. Sajjad Fazel is a public health researcher in the Cancer Epidemiology and Prevention Research Department at Alberta Health Services. He is also the research director for Knight’s Cabin – an NGO assisting cancer survivors to adopt a healthy lifestyle. His research focuses on three main areas; health promotion and misinformation, cancer prevention, and tobacco control. Devoted to science communication, Sajjad created the Afya Yako program – a health promotion initiative that improved the health literacy of over 100,000 Tanzanians. In 2019, Sajjad was voted among the top 50 most influential Tanzanians. He is currently working with a team of researchers across Canada studying Covid-19 misinformation. Sajjad holds a Doctor of Pharmacy degree from Manipal University, India and a Master of Public Health from Western University, Canada.He can be found online on Instagram @sajjadfazel as well as twitter @sajjadfazelLike Us, Follow, Subscribe, Share, and leave a review if you like what you hear.Available on the following social media formats below.Website:www.podcast.healthyourownwaypodcast.comSpotify:https://open.spotify.com/show/5tIfEpBTTyLBSMDdc6SJ9wiTunes:https://podcasts.apple.com/ca/podcast/health-your-own-way/id1485676148Facebook:www.facebook.com/healthyourownwaypodcastInstagram:www.instagram.com/healthyourownwaypodcastIHeartRadio:https://www.iheart.com/podcast/269-health-your-own-way-56951852Google Play:https://play.google.com/music/m/Ipad37sozs2rggcuhz6k2rsyllq?t=Health_Your_Own_WayTwitter: https://twitter.com/hwowaypodcast
SHOW NOTES • https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm • Defoe, Daniel, A Journal of the Plague Year, 1722. • MacMahon, Brian, and Trichopoulos, Dimitrios, Epidemiology. Principles and Methods, 2nd Edition, J.P. Lippincott, 1996. • “Outbreak, On Assignment with Richard Engel,” on MSNBC-t.v., 15 March 2020. • Jane Qui, “How China’s “Bat Woman” Hunted Down Viruses from SARS to the New Coronavirus -- Wuhan-based virologist Shi Zhengli has identified dozens of deadly SARS-like viruses in bat caves, and she warns there are more out there,” Scientific American, March 11, 2020. • Reference to William Farr and John Graunt was provided in an email (3/19/20) to me from Professor of Epidemiology Emeritus Richard Monson, M.D., S.D. • Cancer Causes and Control, an International Journal of Cancer Epidemiology, published in Oxford, England, with editorial offices at the Harvard T.H. Chan School of Public Health. • Wells, H.G., War of the Worlds, 1897.
Why You Should Listen: In this episode, you will learn about deuterium and its impact on our health. About My Guest: My guest for this episode is Dr. T. Que Collins. T. Que Collins, PhD, MA, MS is a leading scientist when it comes to developing and applying nutrition and metabolic therapies to treat cancer in people and pets. He holds a PhD in Clinical Immunology, an MS in Oncotherapeutics, an MA in Experimental Pathology, and a BS in Poverty Health Care and Cancer Epidemiology. He is the Co-Founder and Principal Investigator at Cignature Health Metabolic Clinic now known as the Center for Deuterium Depletion. This is the first clinic in the world to use deuterium and tracer technologies to describe and follow the health status of patients with metabolic disorders such as cancer, diabetes, and autoimmune disorders. He is the Principal Investigator at Epigenix Foundation. This not-for-profit organization created by the founders of Quest Nutrition promotes research to prevent and ameliorate disease, maximize quality of life, and improve personal performance. He is also the Co-Founder and Principal Investigator at Ketopet Sanctuary. The sanctuary is a 53-acre ranch outside Austin, Texas that uses the ketogenic diet and other metabolic therapies with and without standard of care to treat dogs with naturally occurring cancers. Key Takeaways: - What are hydrogen and deuterium? - What symptoms and conditions are associated with elevated deuterium? - Does deuterium create an environment that is hospitable to pathogens? - What is deuterium depletion the basis of all functional medicine? - What is the D-TERMINATOR testing, and what does it reveal? - What functions in the body improve as deuterium is depleted? - Does drinking water increase deuterium levels? - What is the best type of water to drink? - Can deuterium depleted water be made at home? - What is the role of hydrogen water in a deuterium depletion discussion? - What foods increase and decrease deuterium levels? - Why is a higher fat diet helpful in depleting deuterium? - Do supplements have high levels of deuterium? - How might photobiomodulation support depletion of deuterium? - Do specific breathing exercises have a role in a deuterium depletion protocol? - Once deuterium levels are depleted, is a maintenance protocol needed? Connect With My Guest: http://DDCenters.com Interview Date: April 14, 2020 Transcript: To review a transcript of this show, visit http://BetterHealthGuy.com/Episode117 Additional Information: To learn more, visit http://BetterHealthGuy.com. Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.
We eat this delightful legume in so many forms, from tofu, to soymilk, edamame and more! But, did you know that in addition to serving as a great source of plant proteins for the diet, that soy has also shown a number of fascinating health benefits in cancer prevention? In this episode, I speak with Dr. Omer Kucuk, a cancer researcher and physician who also happens to be an expert on the therapeutic value of soy-based foods and supplements. About Omer Kucuk Omer Kucuk, MD, conducted the first clinical trials to show the benefits of soy and lycopene supplements in prostate cancer treatment. He is a Professor in Hematology and Medical Oncology at Emory University’s Winship Cancer Institute. Dr. Kucuk came to Emory Winship from the Karmanos Cancer Center at Wayne State University in Detroit where he was a professor and co-leader of the population sciences and prevention program and member of genitourinary and head and neck cancer multidisciplinary groups. Dr. Kucuk has more than 250 peer-reviewed publications, review articles and book chapters to his credit, and he is on the editorial boards of numerous publications, including the Cancer Epidemiology, Biomarkers and Prevention and Cancer Epidemiology. Nutrition and cancer is Dr. Kucuk’s primary research focus, and he has published extensively on various nutrients in combination with chemotherapy and radiation. Dr. Kucuk has been conducting clinical trials with lycopene and soy isoflavones in combination with standard therapy for prostate cancer since 1995. He is also investigating the effects of micronutrients and phytochemicals on biomarkers of cell growth, differentiation, inflammation and oxidative stress in a variety of cancers. Dr. Kucuk earned his medical degree at Hacettepe University Medical School in Ankara, Turkey. He conducted a residency and fellowship at St. Francis Hospital in Evanston, Illinois, and a hematology and oncology fellowship at Northwestern University Medical School in Chicago. Before joining the medical staff at Wayne State University, Dr. Kucuk served as professor and researcher at the University of Hawaii’s John A. Burns School of Medicine in Honolulu. About Cassandra Quave Prof. Cassandra Quave is best known for her ground-breaking research on the science of botanicals. Scientists in her research lab work to uncover some of nature’s deepest secrets as they search for new ways to fight life-threatening diseases, including antibiotic resistant infections. Working with a global network of scientists and healers, Cassandra and her team travel the world hunting for new plant ingredients, interviewing healers, and bringing plants back to the lab to study. Besides research, Cassandra is an award-winning teacher, and has developed and taught the college classes “Food, Health and Society” and “Botanical Medicine and Health” at Emory University. @QuaveEthnobot on Twitter @QuaveEthnobot on Instagram @QuaveMedicineWoman and “Foodie Pharmacology with Cassandra Quave” on Facebook
The good folks from The in Los Angeles, where I traveled to record this podcast episode. The Center for Deuterium Depletion's mission is to promote deuterium depletion research and therapies to prevent or ameliorate disease, maximize quality of life and/or improve personal performance. Deuterium is a naturally occurring element. You acquire deuterium through the food you eat, the liquids you drink and the air you breathe. Your body's ability to deplete deuterium decreases with weight gain, age, illness and lack of quality sleep. Deuterium is a rare type of hydrogen – only 155 out of every million hydrogens are deuterium. Its nucleus contains a proton and a neutron, which makes it twice the mass (weight/size) of regular hydrogen. My guests on this show believe deuterium in tissue should not exceed 130 ppm (parts per million) and they base this value on the deuterium levels found in a broad number of plants, animals that are grass fed and the food products of grass fed animals - butter, milk, tallow, etc. Unfortunately, many people are now saturated with deuterium and this affecting their mental and physical performance. On today's show, you'll learn exactly why that is, and what you can do about it. My guests on this show are Dr. Anne Cooper and Dr. Que Collins. A native of Australia, Dr. Anne Cooper, D.C., LAc. earned her Doctorate in Chiropractic from Cleveland Chiropractic College (Los Angeles), graduating with Honors in 1997, while on the Dean’s list and winning the Charles Gibson award for clinical excellence. Her growing commitment to total health and innovative healing therapies led her to continue on with over 20 years post-doctoral experience in Functional Medicine and a Masters degree in Acupuncture and Traditional Chinese Medicine, graduating with highest honors in 2011. Early in her career, as a celebrity aesthetician, working with great beauties such as Ava Gabor, she realized that where there is beauty, there MUST be health and that health must be established on a very deep cellular level. Anne's credentials: Master’s in Acupuncture & Traditional Chinese Medicine (Highest Honors) Doctorate of Chiropractic (Honors) Charles Gibson Clinic Entrance Award Licensed Aesthetician Certifications: Clinical Nutrition, Applied Kinesiology, Functional Medicine, Energetic Medicine, Herbal Medicine Dr. Cooper manages patients and guides their day-to-day therapy. She also is our healthcare professional liaison and helps them implement our protocols and services into their practices. Her expertise as both an experienced natural and functional medicine practitioner helps bridge any communication gap between our principal and chief scientists training in allopathic medicine and the training received by chiropractors, naturopaths, acupuncturists, herbalists, nutritionists, etc. Dr. Que Collins is a leading scientist when it comes to developing and applying nutrition and metabolic therapies to treat cancer in people and pets. Ph.D., Clinical Immunology M.S., Oncotherapeutics M.A., Experimental Pathology B.S., Poverty Health Care and Cancer Epidemiology He is Co-Founder and Principal Investigator at – the first clinic in the world to use deuterium and tracer technologies to describe and follow the health status of patients with metabolic disorders such as cancer, diabetes, and autoimmune disorders. Principal Investigator, Epigenix Foundation – this not-for-profit organization created by the founders of Quest Nutrition promotes research to prevent and ameliorate disease, maximize quality of life and/or improve personal performance. He is also Co-Founder and Principal Investigator of Ketopet Sanctuary – a 53-acre ranch outside Austin, Texas that uses the ketogenic diet and other metabolic therapies with and without standard of care to treat dogs with naturally occurring cancers. During our discussion, you'll discover: -What exactly is deuterium anyway?...7:30 A form of hydrogen Deuterium has an extra which makes it twice as big and twice as heavy Deleterious effects on our mitochondria when present in water Produces ATP; depending on hydrogen ions Deuterium "gums up the machine" due to its size Hydrogen atoms are replaced by deuterium when deuterium is present We actually make deuterium depleted metabolic water inside our mitochondria -Deleterious effects of deuterium on the mitochondria and cells...10:30 Clinical tests showing its effects on the mitochondria/metabolism are fairly recent Deuterium stops up the electrode transport chain; results in excessive energy within the cells Affects cell integrity Changes electromotive constant of cells Bottom line: Hydrogen holds us together; the size and density of deuterium changes the whole structure inside our cells -Why present levels of deuterium in the modernized environment are problematic...14:15 While deuterium is a natural and essential element, its presence has increased in the modernized environment: foods, atmosphere, water Climate change has released deuterium previously stored in ice caps Ice is dated by measuring the deuterium level (deuterium dating) Processed, synthetically made foods increase glyphosate GMO foods possess high amounts of deuterium Deuterium levels in food will vary based on where it's grown (highest in the equator and in low elevations) -Lifestyle practices that have led to increased deuterium levels...19:45 Lack of sleep, particularly deep REM sleep REM sleep we burn up carbs, go into ketosis Someone on a ketogenic diet doesn't need as much REM sleep as someone who isn't Breathing: fast, through the chest vs. diaphragm -The best way to test one's deuterium levels...28:00 D-Terminator test (condensation from lungs) Saliva and urine Water sources: well or municipal Major water brands typically have high deuterium levels Animals that are fed corn and soy will have high deuterium in their meat Grains in general are high in deuterium -Why companies sell deuterium-depleted water when we possess the ability to make it ourselves...33:30 It's a short-term biohacking tool DDW was originally formulated for cancer patients A cancerous cell is simply a normal cell with a different metabolism Deuterium gets into the DNA and is not allowed to fold Cancer cells can't use the TCA cycle Bottom line: DDW makes cancerous cells dysfunctional and supports healthy cells Primary therapies: Air, food, water, sunshine, natural therapies, appropriate exercise, thought processes, support from family and friends -The mask that Hollywood stars use to increase their tolerance to Co2 while exercising...39:45 We breathe in .5 to 1 liter of water while we sleep (especially in humid or tropical climates) Mask allows you to drink DDW while you sleep -Other blood biomarkers that correlate to deuterium levels...42:10 Mitochondrial health markers: CRP, HRV, iron, and more Modern medicine views it as a sign of disease; it's actually a sign of high deuterium levels -Why the Center for Deuterium Depletion doesn't advocate drinking DDW as a permanent solution...44:15 DDW shouldn't be used as a "crutch" It's a holistic approach, of which water is merely a component The amount of DDW a person should consume is protocol-specific (cancer patient vs. a wellness warrior) DDU: deuterium depletion unit Deuterium levels can be dropped in 2 weeks with water alone; takes longer for more comprehensive results -How DDW is made and manufactured...48:45 Distillation tower (capturing steam, freezing, extracting deuterium) Became necessary in communist countries where deuterium rich water was used to make bombs -Dietary adjustments to decrease deuterium levels...50:30 Green plants are lower in deuterium than fruits Algae and spirulina contain high chlorafil amounts Roots and underground veggies are very starchy Your metabolic response will help determine your needs No diet is better than the other, so long as you understand the deuterium load in it and adjust appropriately Think "lifestyle" vs. diet, water consumption, etc. -And much more... Resources from this episode: - - to purchase a D-Terminator DDW test to test your own deuterium levels - to buy D-Water Test Episode sponsors: -: The Recovery Bundle at Kion includes all the things I take when I'm training super hard, or really sore, or battling a nagging injury. It includes Kion Flex, Kion Aminos, and LivingFuel SuperEssentials Fish Oil. BGF listeners, get a 10% discount off your order when you use discount code: "BGF10" -: A plant-based beverage that helps support the body’s natural ability to produce collagen, smooth fine lines and wrinkles, and protect the skin from sun exposure and toxins. Receive a 20% discount on your entire order when you use discount code: "BENG20" -: Activewear and athletic clothing for ultimate performance. Vuori is built to move and sweat in, yet designed with a West Coast aesthetic that transitions effortlessly into everyday life. Receive 25% off your first order when you use discount code: "BEN25" -: Clean design, minimal and high quality products. MVMT watches start at just $95 and have sold nearly 2 million watches in over 160 countries. Get 15% off your order PLUS free shipping and free returns when you order through . Do you have questions, thoughts or feedback for Dr. Cooper, Dr. Que or me? Leave your comments below and one of us will reply!
Chapter 1 32 arrested in India after allegedly posing as Canadian officials in call centre fraud Guest: Amanda Connolly, Global News Political Reporter in Ottawa Chapter 2 Hong Kong Polytechnic University campus burns as protesters, police clash Guest: Gloria Fung, President of the non-profit group, Canada-Hong Kong Link Chapter 3 Prince Andrew slammed for response to Epstein connections in BBC interview Guest: Patricia Treble, Royal watcher at Maclean's for almost 20 years Chapter 4 Rate of cancers related to obesity rising among young Canadians Guest: Dr. Christine Friedenreich, Cancer epidemiologist with the Department of Cancer Epidemiology and Prevention Research of Alberta Health Service Chapter 5 Good news in the winter forecast for B.C. Guest: Anthony Farnell, Global News Chief Meteorologist Chapter 6 Canada's first telephone resource for B.C. youth mental health celebrates a milestone Guest: Dr Jennifer Russel, Compass's clinical director, BC Children's Hospital Chapter 7 Travel Best Bets: what to do when a protest affects your travel Guest: Claire Newell, President and Founder of Travel Best Bets
Rate of cancers related to obesity rising among young Canadians Guest: Dr. Christine Friedenreich, Cancer epidemiologist with the Department of Cancer Epidemiology and Prevention Research of Alberta Health Service
Common things are common, and the boards love to test on these. In this episode, we’ll hit the most common types of cancer that affect children and adults, and review as many testable topics as we can. This cancer episode is packed with fun facts, so don’t worry if you’re overwhelmed. Cancer is a mighty beast but hopefully together we can start to tackle it!
Cindy S.H.: Hi. Welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal Circulation Research. I'm your host, Cindy St. Hilaire, and my goal is to bring you highlights of articles published in the Circ Research Journal as well as have in-depth conversations with senior scientists and the junior trainees who have led the most exciting discoveries in our current issues. Today is our premier episode, so I want to take some time to introduce myself, give you a little bit of background about the history of the journal, and then have a conversation with our new editor in chief, Dr. Jane Freedman, and my social media editor partner in crime, Dr. Milka Koupenova. Cindy S.H.: First, a little bit about me. I'm an assistant professor of medicine and bioengineering at the University of Pittsburgh. My lab is part of the division of cardiology and we're also a member of the Pittsburgh Heart, Lung and Blood Vascular Medicine Institute. I'm still a relatively new PI. I'm still learning as I go. One of the strengths of being a new PI in the current time is the amazing network we have through social media, whether it's through listening to podcasts or through Twitter or through select groups like one of my favorites, New PI Slack. Really one of my personal goals of starting this podcast for Circ Research is to have a career development angle. Because career development is so fresh in my mind and it's really something I want to incorporate into this podcast, we're hoping we can reach out to more junior trainees through these mediums. Really that's the impetus for Dr. Freedman wanting to have specific social media editors at the Circulation Research Journal. Cindy S.H.: I'm very honored to be the first host of this podcast and I'm very excited for this opportunity. As a team, Milka and I hope to expose the larger community to not only the most current and exciting discoveries in cardiovascular research but also a behind-the-scenes look of what it takes to get high-impact research done and published and planned and funded, and also talk about some of the maybe the non-bench aspects of this job, the networking, the behind-the-scenes look that really you learn on the fly as you go. Hopefully we can expose more people to these on-the-fly things in a slightly more rigorous manner. Cindy S.H.: Before I go into the articles summarized in this week's podcast, I want to give a very big thank you to Ruth Williams. Ruth is the person who writes the content of the In This Issue which is featured in every issue of the journal Circulation Research, and that content is extremely helpful in deciding which articles we're going to focus on in this podcast and also for helping me form the conversations and discussions. Thank you, Ruth, for all your hard work. Cindy S.H.: Now I'm going to highlight three articles that were featured in the June 21st issue of Circulation Research. The first is entitled Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality: A 30-Year Prospective Cohort Analysis. The first author is Jiaqi Huang and the corresponding author is Demetrius Albanes , who are both at the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, which is at the NIH in Bethesda, Maryland. Alpha-tocopherol is the more formal name for vitamin E, and vitamin E is an essential fat-soluble vitamin. By essential, that means that while your body absolutely needs it, it does not produce it itself. Therefore we need to consume products containing vitamin E. We do that by eating vegetable oils, nuts, seeds, whole grains and certain fruits and vegetables. Previously, population-based studies have shown inconsistent associations between circulating vitamin E and risk of overall death or death due to specific diseases such as cancer and cardiovascular disease. Cindy S.H.: To look more closely at cause-specific mortality, Huang and colleagues studied a cohort of close to 30,000 Finnish men, which is a huge study. Added to that, these men were in their 50s and 60s at the start of the study and then continued for the next 30 years of their life to be in this study. It's frankly an amazing achievement to keep that many individuals enrolled. From approximately 24,000 deaths, so about 80% of the original cohort, the authors adjusted for factors such as age and confounding things like smoking. They found that vitamin E levels were inversely associated with the risk of death from a variety of causes. What that means is that higher levels of vitamin E associated with lower risk of death. All of those causes of death that they found were cardiovascular disease, heart disease, stroke, cancer, and respiratory disease. This large prospective cohort analysis provides very strong evidence that higher vitamin E levels means greater protection. Cindy S.H.: It's really interesting to note though that this data did not seem to associate with a reduced risk of death by diabetes or, for that matter, injury and accidents, which I guess kind of makes sense. The authors say these results indicate that vitamin E may influence longevity, but they also highlight the need for further studies, specifically in more ethnically diverse populations and of course in women, because we all know a major limiting factor of a majority of cardiovascular studies is the fact that often there are just not enough women in these studies. But really that's a push now to include not only women but more ethnically and geographically diverse populations. Cindy S.H.: The second article I want to highlight is titled Mitochondria Are a subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells . The first authors are Florian Puhm and Taras Afonyushkin , and the senior author is Christopher Binder. All three are in the Department of Laboratory Medicine, the Medical University of Vienna, in Vienna, Austria. This group is also part of the Research Center of Molecular Medicine of the Austrian Academy of Sciences. Cindy S.H.: I want to talk about this paper because I found that title extremely provocative. Extracellular vesicles or microvesicles are small particles that can be released from cells. These particles can act as cell-cell communicators. They can hold a variety of substances such as proteins and micro RNAs and minerals and all sorts of things that are derived from inside the cell. The matrix vesicle is then budded off. Matrix vesicles released from monocytes after bacterial LPS stimulation, so a stimulus that induces an inflammatory response, these matrix vesicles have been shown to contain mitochondrial proteins. Mitochondrial DNA-containing matrix vesicles have been reported in the mouse model of inflammation. From this premise, from these prior studies, Dr. Puhm and colleagues hypothesized that the mitochondrial content of matrix vesicles might actively contribute to pro-inflammatory effects. Cindy S.H.: What they then did was show that monocytic cells release free mitochondria and also matrix vesicles that contain mitochondria within them. These free and matrix vesicle-encapsulated mitochondria were shown to drive enothelial cells to induce inflammatory cytokines such as TNF-alpha and interferon. These circulating matrix vesicles were collected also in human volunteers that were injected with this same inflammatory substance, LPS. These circulating matrix vesicles isolated from humans also induced endothelial cell cytokine production. Very interestingly, inhibition of the mitochondrial activity drastically reduced the pro-inflammatory capacity of these matrix vesicles. Cindy S.H.: Together, this result suggests that the released mitochondria, whether it's free or whether it's encapsulated in a matrix vesicle, may be a key player in certain inflammatory diseases. This study shows that in addition to their central role in cellular metabolism, mitochondria, whether encapsulated or free, can actively participate in an inflammatory response in a cell other than the cell it was native in, which is just intriguing to think about. This work provides new insight to the contribution of mitochondria to the content and biological activity of extracellular vesicles. It also might suggest that perhaps targeting mitochondria and their release may represent a novel point for therapeutic intervention in inflammatory pathologies. Cindy S.H.: The last article I want to highlight is titled Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation . The first author is Bijun Chen and the senior author is Nikolaos Frangogiannis . When tissues are injured, there is localized increase in the cytokine TGF-beta. However, depending on conditions, this TGF-beta can function to stimulate macrophages to adopt either pro-inflammatory or anti-inflammatory phenotypes. To complicate matters more, the signaling pathway for both the pro- and anti-inflammatory phenotypes involves activation of the intracellular signaling protein Smad3. Inflammation, whether too much or too little, can influence the outcome of injuries, including injuries such as myocardial infarctions. An infarction, for those of you unfamiliar with the term, is a localized area of dead tissue and that results from a lack of blood supply. In this case, an infarction, a myocardial infarction, is essentially a heart attack that stops blood flow through the coronaries and causes death in the cardiac tissue and cells. Cindy S.H.: The authors hypothesized that in the infarcted myocardium, activation of TGF-beta and Smad signaling and macrophages may regulate repair and remodeling. They had a very specific question about a very specific cell type in the context of the whole heart. To address the role of Smad3, they utilized mice that were engineered to lack Smad3 in the myeloid lineage which produces macrophage cells. They found that these mice with myeloid cell-specific deletion of Smad3 had reduced survival compared to control mice. Additionally, the hearts from the animals with the myeloid cell-specific deletion of Smad3 exhibited increased adverse remodeling and greater impairment of function. That's a really interesting finding. The heart tissue itself was the same. All that was different were the cells of the myeloid lineage. Then to dig after what cells were mediating this effect, the investigators moved on to in vitro studies. They found that Smad3-lacking cells themselves showed reduced phagocytic activity, sustained expression of pro-inflammatory genes, and reduced production of anti-inflammatory mediators when compared with control macrophages. Cindy S.H.: In summary, these results suggest Smad3 is necessary for macrophages in the area of the infarction to transition to an anti-inflammatory phagocytic phenotype that protects against excess remodeling. However, we cannot go after global inhibition of Smad3 as a potential therapy post myocardial infarction, and that's because inhibition of Smad3 in cardiomyocytes is actually protective against the infarction. Inhibition in a macrophage is bad, but inhibition in a cardiomyocyte is good. Any potential Smad3-modifying therapies really needs to be designed to be cell type-specific and be able to be deployed to activate that cell type. Cindy S.H.: In addition to science, I love history. I thought I would take this opportunity of the first podcast to share with you a little bit of history about the Journal of Circulation Research. Circulation Research is now in its 66th year, but its origins can be traced to 1944. That was when the AHA established a council that was attempting to organize its research arm and its professional program arms. The AHA journal Circulation was already in existence, but in 1951 the executive committee decided to launch a basic research supplement, and it was called just that: Circulation Basic Research Supplement. But a few years later, Circulation Research was to be its own publication because of the interest and the excitement around the basic research supplements. The quote that I'm going to read is from that first executive committee meeting and there they wanted Circulation Research to be the authoritative new journal for investigators of basic sciences as they apply to the heart and circulation. Cindy S.H.: It's a fun little subgroup that they list after that. They list in anatomy, biology, biochemistry, morphology, which I just think is so neat to think about, pathology, physics, pharmacology, and others. It's interesting to think about what that would be today if we were now finding this journal. Biochemistry, genetics, molecular biology. It's fun to think about how much science has changed since they began this journal. Really the broader goal was to integrate and disseminate new knowledge. Leading that was Dr. Carl Wiggers, who was the first editor in chief of Circ Research. At the time, he was the head of physiology at Western Reserve University, and he's often referred to as the dean of physiology, as his research really provided much of the fundamental knowledge regarding the pressures in the heart and the vessels of the body and how they interact. Cindy S.H.: I actually went back and looked at some of the first titles in Volume One, Issue One, of Circ Research. It's really kind of neat. Some of them could be completely relevant today. I'm just going to read a few. Nucleotide Metabolism and Cardiac Activity, Fundamental Differences in the Reactivity of Blood Vessels in Skin Compared to Those in the Muscle. That was at the VRIC the other day. Haemodynamic Studies of Tricuspid Stenosis of Rheumatic Origin. Reading these for the first time I actually got chills because my two themes of my lab are both in that first Volume One, Issue One, of that journal. I study the extracellular nucleotide aCD73 and its impact on vascular homeostasis. I also study calcific aortic valve disease and are hugely curious about the role of inflammation and things like rheumatic heart disease in the progression of the disease. It's amazing how much science has changed, but yet how so much has stayed the same. Cindy S.H.: Dr. Wiggers wrote a few gems, a few quotes in his biography that I want to share with you. I find them inspiring and also humbling. The first is, "Research is a gamble in which the laws of chance favor the loser. The loser must remain a good sport," which I think is perfect to think about in science. I really wish I had read that after my first RO1 was triaged. The next two are more about the science writing and I think they're great not only for when we're thinking about papers but also grants. The first is, "Readers are greatly influenced in their judgment of a research project by literary style. A poor presentation can easily damage the best investigation," which is so true. No matter how good your science is, if you can't communicate it, it doesn't matter. And lastly, "A good paper, like a good glass of beer, should be neither largely foam nor flat. It should have just the right amount of head of foam to make it palatable." Cindy S.H.: With these nuggets of wisdom, we're now going to talk with Drs. Jane Freedman, who's now the editor in chief of Circ Research, and Dr. Milka Koupenova, who is the social media editor. Before I really introduce Jane, I want to recognize all of the former editors in chief of Circ Research, Dr. Carl Wiggers, Dr. Carl Schmidt, Dr. Eugene Landis, Dr. Julius Comroe, Dr. Robert Berne, Dr. Brian Hoffman, Dr. Francis Abboud, Dr. Harry Fozzard, Dr. Stephen Vatner, Dr. Eduardo Marbán, Dr. Roberto Bolli, and now Dr. Jane Freedman. Welcome, Jane. Thank you so much for this opportunity and congratulations on your new position. Dr. Freedman: Thank you very much. Cindy S.H.: I was wondering if you could just introduce yourself to the listeners and give us a little bit about your background. Dr. Freedman: Sure. I am the Budnitz Professor of Medicine at the University of Massachusetts, and I originally became interested in a scientific career while attending Yale University where I was both an architecture and geology major. Cindy S.H.: Interesting. Dr. Freedman: Yes, very interesting. Then, not exactly knowing what I wanted to do, I worked for a year as a research assistant for my later-to-be mentor Dr. Joe Loscalzo at Brigham and Women's Hospital. There one day he sent me up to the intensive care unit and said we need to get a tube of blood from someone who was in the throes of having a myocardial infarction. Really at that point I became hooked. Why was that person having a heart attack, and using their blood how could I figure out whether they would live, die, do well, not do well, or yield new things that might help us cure or diagnose people with heart attacks later on? After that. I went to Tufts Medical School. I did my residency and cardiology fellowship at Brigham and Women's Hospital and the Massachusetts General Hospital. After working at several different places, I have wound up at the University of Massachusetts where I am in the Division of Cardiology and where my laboratory currently resides. Cindy S.H.: Excellent. As the new editor in chief, what do you see as your vision for the journal? Dr. Freedman: I'm in a very fortunate position to be taking over a wonderful journal from an incredibly dedicated group of editors and associate editors and other supportive editors. Scientific pursuits and reporting and publications are really evolving at a rapid clip, so we hope to have several things happen over the next few years to survive and thrive. The first thing is we hope to define and expand Circulation Research's scientific identity. We want to extend its already outstanding portfolio of science that really demonstrates how elegant basic and translational mechanisms and pathways are part of a greater web of cardiovascular disease and stroke. This will include an increasingly diverse group of basic and translational sciences and they'll touch on both fundamental studies as well as how they translate to human disease. We also want to continue to pursue the excellence that Circulation Research already epitomizes and we want to extend its brand both to an increasingly diverse group of members, both nationally and internationally. Dr. Freedman: Circulation Research already has really wonderful publication metrics such as turnaround time, time to review, and we hope to maintain that so as to be a journal of choice for an increasingly growing number of investigators. We would also very much like to have greater interface with the American Heart Association. A lot of the research on our pages is funded by the American Heart Association, and the majority of science that the American Heart Association currently funds is basic cardiovascular science. We hope to have greater interface and help our users of the journal understand what the American Heart Association can do for them and for their scientific pursuits. Dr. Freedman: Last and very importantly, we really want to attract early and mid-career investigators to the journal. We already have some really nice programs that the previous editorship has started, such as Meet The First Author, but we would also like to be a site for education of how you can review papers, have a junior editor program and other types of programs that will help early and mid-career investigators in their future. One of the ways we're going to be doing that is to have enhanced social media programs. Cindy S.H.: Great. I really like that idea of having the junior editors because I think the best learning experience I had about how to write a grant did not happen until I actually served on a study section, because it was there you actually can understand all of those comments you got on your first grant that was triaged and why they were said. I think that is a key and really important aspect. Dr. Freedman: That's a perfect analogy because you want to remove the black box that people think is happening when they send their manuscripts in. There's so many reasons why manuscripts succeed and don't succeed, and we really do want to be as transparent as possible and we do want to educate investigators as much as possible about the process. Cindy S.H.: Actually, could you maybe tell us a little bit about that process? I made all my figures, I formatted my paper according to the instructions, I hit submit. Black box. What happens? What's the next step? Dr. Freedman: What's the next step? Cindy S.H.: What do you do? What does an editor in chief actually do? Dr. Freedman: I do have to say that none of this would happen, especially in the incredibly quick turnaround time, if we didn't have amazing support and help in our office that happens to be in Baltimore. The people there are just incredible. They make sure that papers move through. It's really 24/7. Our group has not been at it for very long, but I know Dr. Bolli's group as well as our group, people are handling manuscripts as fast as they really come in. We see the manuscript, they get quality checked. We try not to be too onerous with the first steps. Then typically they go to one of the associate or deputy editors who will handle them to send out for review. Cindy S.H.: Is that based on keywords or the title or how is that decided? Dr. Freedman: Sometimes it's based on keywords, so careful with your keywords. A lot of times, because each of the associate editors has an area of expertise that hopefully covers what your science is interested in, they will know experts in the field. We very heavily rely on our editorial board. We have an amazing editorial board at Circulation Research, and amazing contributions from the BCBS council. These individuals have over the years and currently provided just tireless and unsung, devoted help to making the journal run smoothly. It's a pretty quick turnaround time. Then the decision made based on the reviews of the article. Occasionally articles come in and they're not suitable for the journal because they're not what we perceive as what our readers would be interested in. Sometimes those articles don't go up for review. We don't want to keep them caught up, so we send them back right away. Dr. Freedman: When the articles come back in with the reviews, we're going to be discussing them at a weekly meeting. Other viewpoints will weigh in, and then we make a decision whether it's an accept, whether it's a revise, whether it needs a lot more science. That's called a de novo. Sometimes we think it's more suitable for one of the other 11 American Heart Journals and we might suggest that you consider sending it to that journal and we consult with that journal's editor. Cindy S.H.: Interesting. All that happens with about 14 days. Dr. Freedman: That's supposed to happen with 14 days. Cindy S.H.: It does pretty regularly based on the stats. That's amazing. One of the initiatives you mentioned was really the role of social media. Now I would like to introduce Dr Milka Koupenova, who is the co social media editor alongside me. Before I let Milka talk, I really have to be honest and say that my graduate school days were some of the best of my life. It was in part because Milka I were both in the same lab. We overlapped by a couple of years under the amazing mentorship of Dr. Katya Ravid. Every time we get together, all we'd talk about was how can we be like Katya? Maybe someday we'll actually have a podcast where we can get Katya in here and actually record all her nuggets of wisdom. Dr. Koupenova: I think the same thing about Katya. Cindy S.H.: How can it be more like Katya? But for now, Milka, welcome. Thank you. If you could just introduce yourself and give us a little bit about your background. Dr. Koupenova: Hi, everybody. My name is Milka Koupenova. I am an assistant professor at University of Massachusetts Medical School. Briefly about me, as Cindy mentioned, I did my PhD at Boston University and I studied at that time metabolism in atherosclerosis. Then I had this great opportunity to join this lab in thrombosis that studied these little cell fragments called platelets, which I knew something but not that much about. I joined Dr. Freedman lab as a postdoctoral fellow, and actually my interest evolved to be very much in platelet immunobiology and how platelets may contribute to thrombotic disease during viral infections. Luckily for me, I had two angels that I wanted to be. One of them was Katya Ravid, as you mentioned, and the other one was Dr. Freedman. Both set up a great example of scientists and how to do science in life. Cindy S.H.: Wonderful. Excellent. Thank you. I won't lie. I don't know if you feel this way. I definitely feel a little nervous about being a social media editor. I'm talking in a room to a box with a microphone on me and I don't know who's going to be listening. That's also exciting for me too. I get to disseminate all this cool knowledge and share our basic research with this huge audience. What are you most nervous about and excited about? Dr. Koupenova: You're doing the podcast, so I don't have to worry about that, that that particular part. I am quite excited actually about everything that's going to surround popularizing the science at Circulation Research. I think in the time that we live in and when social media is a huge part of our life, we definitely need to engage the community, scientific or lay, and communicate our ideas. I'm super excited about the creative part behind how we are going to achieve this via various social medias. Cindy S.H.: Can you talk about the platforms that you plan on using? Dr. Koupenova: We currently are using Twitter and Facebook. Please follow us on Twitter and Facebook. And we are going to launch Instagram. Find us, follow us, engage us. That will be great. You can always send us messages and like us, retweet whatever you decide. Cindy S.H.: Give podcast feedback on Twitter. Nice comments only. Dr. Koupenova: We'd like to hear your comments and we'd like to hear what you envision in certain cases when it comes to your Circulation Research, because this is your journal as much as it is ours. We're here for you. In addition to popularize and advertise the wonderful science that we're publishing in Circ Research, we want you to be engaged. We want you to be able to advertise in your own work and to think of it as something that you own and something you need to communicate to the rest of the world. That is one of the things that we want to do. Dr. Koupenova: Finally I'm going to echo on what Dr. Freedman said, is we want to attract truly early career and young investigators and help them be involved, help them own their science and help them communicate their ideas. That's pretty much what our social media platform is and we are going to evolve with you. That is perhaps one of the challenges. Cindy S.H.: I think one of the most interesting aspects, at least in academia as I see it, is really the role of self-promotion. It's something you're never taught and it's something that you don't really appreciate until you go to that conference. I remember my first conference as a new PI, I was standing there and I'm just like, "Okay, these are all other PIs. How are they all in groups? How does everybody know each other? Why are they all friends already?" It takes a lot of guts and you have to inject yourself. "Hi. I'm Cindy St. Hilaire and I'm new. Please be my friend," essentially, essentially. But it's important and I really liked the fact that when your journal is published you have that little button, share on Twitter, share on Facebook. I think that's really important. It helps you practice that self-promotion and can help really allow you to embrace your extrovert when you know how to. Dr. Koupenova: That's exactly what I was going to point out. Scientists or physician scientists, or physician scientists perhaps are a bit better. But as scientists we're very much introverted. But social media gives you a platform that it's not cheesy to popularize and communicate. Then you see those people on conferences and then you have your little group without- Cindy S.H.: It's amazing how many Twitter friends I have. "Oh, I met you on Twitter. It's so nice to meet you in real life." Dr. Koupenova: It's a new generation. We at Circ Research want to evolve with it. Is that correct, Dr. Freedman? Dr. Freedman: That is correct. Thank you very much. Cindy S.H.: It's exciting times. I guess maybe this is a question for all of us to talk about, but how do you think we can, number one, attract people to science, attract diverse people to science, and then really keep them in science and how do you think we can use Circ Research and also the social media aspects of Circ Research to do that? Dr. Freedman: I think, first of all, people have to see themselves in the journal. The journal, I think the first point I talked about, about being inclusive, inclusive types of people, way people consume science, types of science. We really want people to feel like Circ Research isn't just a journal that puts out scientific papers, but is a forum. It's a forum for them to exchange ideas and it's a forum for them to understand better about their scientific careers. Cindy S.H.: Great. Thank you. This has been an amazing first podcast. I'm so happy to share it with the two of you and I'm super excited for this opportunity. Again, Jane, I want to congratulate you on your new position as editor in chief and I can't help but mention as the first female editor in chief. That's a wonderful, wonderful thing. Cindy S.H.: You can find us on Twitter. The handle is @CircRes, at C-I-R-C-R-E-S. We're also on Instagram using the same name, C-I-R-C-R-E-S. We hope to hear from you there. Cindy S.H.: Thank you for listening. I'm your host, Cindy St. Hilaire, and this is Discover CircRes, your source for the most up-to-date and exciting discoveries in basic cardiovascular research.
Associate Professor Anne Cust heads the Cancer Epidemiology and Prevention Research group at the Sydney School of Public Health. She specialises in cancer epidemiology and shares her research and career journey with us here!
LIFE at Conception Texas Spreads, Abortion foes mount direct challenges to Roe v. Wade, A NEED FOR A MISSILE DEFENSE SYSTEM RATHER THAN A SPACE FORCE, eMail Call President Trump to Meet with Dr Deagle MD and John W Spring ASAP, Laser Net Interferrometry Missile Defense, Gerald Bull Linear Accerlator Cannon, Plasma Missile Net System to Destroy Warheads in Near Space, END Russian and Chinese Financial Hedgemony, END Putin and Xi Violation of Monroe Doctrine, STOP Venezuelan Children Starving,Dr Bill Deagle MD AAEM ACAM A4M, NutriMedical Report Show, www.NutriMedical.com, www.ClayandIRON.com, www.Deagle-Network.com,NutriMedical Report Show, Abortion foes mount direct challenges to Roe v. Wadehttps://www.detroitnews.com/story/news/nation/2019/04/10/abortion-foes-mount-direct-challenges-roe-wade/39326001/ Dear Friends,After reading the following letter sent to the President, I would urge you to write your own letter to him that is related to this same subject because mine will probably never reach his desk inside the Oval Office at the White House. While it may be rather difficult to comprehend and imagine what life might be like because you were unwilling to take the initiative, at this time, for trying to contact the White House on this very crucial matter, it would be worse than Atom bomb dropped on Hiroshima or Nagasaki in Japan. So, I must ask for your help right now. On your search engine, please type-in: President Donald J. Trump – The White House and at that website, scroll-down to the very bottom where you will see an icon shaped like an envelope. Then click-on that gray icon, which will take you to the website where you will fill-in all of the required information and your email letter at the bottom of that page and follow directions. JWS April 10, 2019 The PresidentThe White House1600 Pennsylvania Avenue, NWWashington, DC 20500 RE: A NEED FOR A MISSILE DEFENSE SYSTEM RATHER THAN A SPACE FORCE Dear Mr. President: Instead of just a private citizen expressing an opinion for a Missile Defense System rather than a Space Force, let me inform you that we are now involved in the Venezuelan Missile Crisis on La Orchila Island, Venezuela in the Caribbean Sea and Punta Huete, Nicaraguain Central America as well as the North Korean Missile Crisis in East Asia and the Western Pacific. But unlike the former Cuban Missile Crisis during 1962 or the Nicaraguan Missile Crisis in 1983 when Grenada was invaded by U.S. Armed Forces, these current crises are already operational.This means we may not be able to prevent Intermediate-Range Ballistic Missiles armed with Thermonuclear Warheads reaching us from the Caribbean and Central America or ICBMs on the Korean Peninsula from also striking at America. While President Franklin D. Roosevelt invited Albert Einstein with an IQ of about 180 to visit at the White House, it should be possible for another private citizen with and IQ beyond 220 to also be invited to meet with you. Dr. Bill Deagle must be invited because of his ability to design an effective Missile Defense System while my understanding of geopolitical and geophysical phenomena is far beyond the various intelligence agencies in Washington, which is why America still exists. Mr. President, you cannot afford to ignore us any more while we are already in such a peril. Sincerely, John W. Spring…http://americanrtl.org/President Donald Trump Understands ISIS but Not AbortionPresident Donald Trump and ISIS: For all his moral failures, President Elect Donald Trump does understand that ISIS is evil and needs to be stopped, not contained or regulated. A dozen organizations joined RegulationsR.us to launch their social media campaign to urge the Islamic terrorist group ISIS to employ more humane forms of killing. A series of messages, each inspired by a specific piece of pro-life legislation, urges ISIS, for example, to use anesthetics prior to a beheading.meme URLs: AmericanRTL.org/isis1.jpg isis2.jpgisis3.jpg isis4.jpg isis5.jpg isis6.jpg isis7.jpg isis8.jpgisis9.jpgSee also regulationsr.us and ChristianNewswire, and see the top five articles linked to in the blue column on the right, or you can email, write or call us:American Right To LifePO Box 1145Wheat Ridge, CO 80034office@AmericanRTL.org1-888-888-ARTLREAD MORE“Brain Dead?” Don’t Trust that DiagnosisBrain dead means not dead.Options: Read this just below.Hear it on radio at rsr.org/brain-dead.Or watch it here via YouTube…These real life examples of people who have recovered after being pronounced “brain dead” shows that doctors and hospitals are sometimes dead wrong:May 2015 – In Des Moines, Iowa as reported by USA Today, “Taylor’s brain sank part way into her spinal canal. No one comes back from that, the doctors told Taylor’s mother, Stacy, and her father, Chuck Hale. Nothing more could be done. Their daughter was brain dead. It was time to make arrangements to take her off life support and discuss organ donation. … Taylor Hale, considered brain dead by science, awoke from her coma. … ” So the staff doctors will harvest organs, cut out the eyes, etc., of living children at the Des Moines Blank Children’s Hospital, hereafter known as Blankity Blank Hospital. See also this, this, this, this, and this.January 2015 – George Pickering, a 27-year old Texan, was pronounced brain dead by doctors at the Tomball Regional Medical Center when his father threatened to shoot himself if anyone disconnected his son from life support. During the standoff with police, the son repeatedly squeezed his father’s hand, and then woke up later that evening, has made a strong recovery, and in April was baptized after converting to Christianity.March 2014 – A Mississippi man wasn’t pronounced “brain” dead, but dead dead, and zippered into a sack, and shipped to the morgue, where he freaked out the workers by kicking his way out of the body bag just as they were ready to embalm him. Shesh. If multiple nurses and a coroner could get death so very wrong, one would hope that the medical industry could have more humility before God regarding patients who are noticably breathing.July 2013 – A New York woman who was pronounced ‘brain dead’ by doctors unexpectedly awoke just as her organs were about to be removed for transplant.READ MOREHarvard Journal of Law and Public Policy: Protecting Prenatal PersonsA prestigious Harvard University publication, Harvard Journal of Law and Public Policy, published an important paper by Josh Craddock, Protecting Prenatal Persons: Does the Fourteenth Amendment Prohibit Abortion?READ MORENCI Researcher Now Admits Abortion/BC LinkNational Cancer Institute Lead Researcher Reverses HerselfNow Admits Abortion/Breast Cancer Risk FactorUpdated June 2017 — NCI Researcher Now Agrees: Louise A. Brinton, largely responsible for getting the government-funded NCI to deny the abortion-breast cancer link, has reversed herself and co-authored a new study which now describes significant breast cancer risk factors including “induced abortion.”“Specifically, older age, family history of breast cancer, earlier menarche age, induced abortion, and oral contraceptive use were associated with an increased risk for breast cancer,” wrote Brinton and her co-authors in the peer-reviewed Cancer Epidemiology journal of the American Association for Cancer Research. The study also says that these risk factors are “consistent with the effects observed in previous studies on younger women.” (See “Risk Factors for Triple-Negative Breast Cancer,” Brinton, et al., American Association for Cancer Research.)Second NCI Scientist to Confirm Abortion Link: “Pro-choice” Janet Daling has reportedthat “[A]mong women who had been pregnant at least once, the risk of breast cancer in those who had experienced an induced abortion was 50 percent higher than among other women.”Endocrinologist Being Vindicated: Endocrinologist Dr. Joel Brind of Baruch College in New York City is the original dissenter at the NCI’s conference that rejected the abortion link to breast cancer. In Dr. Brind’s report on this NCI researcher’s paper, read about another finding reported by Brinton, the 320% increase in risk for women taking the birth control pill to develop TNBC, Triple Negative Breast Cancer, a particularly aggressive and treatment-resistant cancer. Learn more also at AbortionBreastCancer.com and see a 2011 update regarding Johnson & Johnson below.Hear Dr. Brind address these developments in the last few minutes of this Denver radio broadcast:[ download ]Another NCI-funded Research Admitted Link: Janet Daling, et al., in the Journal of the Nat’l Cancer Institute, earlier acknowledged that, “Among women who had been pregnant at least once, the risk of breast cancer in those who had experienced an induced abortion was 50% higher than among other women… Our data support the hypothesis that an induced abortion can adversely influence a woman’s subsequent risk of breast cancer.” Daling is quoted in the L.A. Daily office@AmericanRTL.org. Thx! “>saying, “I would have loved to have found no association between breast cancer and abortion, but our research is rock solid and our data is accurate.”Nov. 2012 Update: Two more studies, as reported in the Asian Pacific Journal of Cancer Prevention, on a combined group of more than 2,000 women, show induced abortion as a significant risk factor for breast cancer.Mar. 2013 Update: Two more studies, from France and China, show that abortion greatly increases the risk of developing breast cancer. And class action lawsuits fly as Ms. Magazine reports on the many deaths from popular birth control pills.Aug. 2014 Update: A review of a dozen studies shows that the abortion breast cancer link explodes in Asia.In Related News:– Good News: Komen Arizona Shuts Down; October 2017 Race Canceled. By their abortion promotion, Komen actually increases breast cancer incidence. True hope against breast cancer is coming from rsr.org/targeted-antibodies and from efforts to abolish human abortion!– Colorado Right To Life Meets with Komen Race for the Cure OfficialsFor Immediate ReleaseColorado Right To LifeTo Join the Race for the Cure ProtestDenver, Colorado — A meeting last Friday between Komen Breast Cancer Foundation’s Denver officials, CRTL board members, and scientific and medical experts led the pro-life organization to decide to join an annual protest to warn women at the Komen Foundation’s Race for the Cure of the link between abortion and breast cancer.Former Komen medical research analyst Eve Sanchez Silver explained to the Komen officials that she resigned from Komen two years ago because the organization denies the scientific studies showing the link between abortion and breast cancer, and it provides funding to abortion provider Planned Parenthood. Professor Joel Brind, PhD endocrinologist from Baruch College in New York City attended the meeting after saying on Denver radio that, “the 2003 conference of the National Cancer Institute which denied abortion as a risk factor for breast cancer refused to allow attending scientists to present the opposing position of the scientific research establishing the link, showing that abortion was declassified as a cancer risk for political and not scientific reasons.”READ MORE For information regarding your data privacy, visit Acast.com/privacy See acast.com/privacy for privacy and opt-out information.
→ Join the Brainjo Collective ← Researcher and writer Bill Lagakos, PhD earned his doctorate in Nutritional Biochemistry and Physiology from Rutgers University, with a focus on obesity, insulin resistance, and circadian biology. He went on to post-doctoral research on inflammation and diabetes, which led to an interest and course of study on circadian rhythm with the Mayo clinic. Bill is the author of the book, “The Poor, Misunderstood Calorie,” and maintains an active blog where he explores health-related topics in the scientific literature. On this podcast with Tommy Wood, MD, Bill discusses critical aspects of entraining circadian rhythm, including the importance of early time-restricted eating. They challenge the concept of chronotypes and discuss why your intermittent fasting program may not be giving you the results you want. Bill also shares his impressions on macronutrient requirements, and the effects of ketosis on body composition and athletic performance. Here’s the outline of this interview with Bill Lagakos: [00:00:22] Bill's Patreon page. [00:00:41] Blog: Calories Proper. [00:03:47] Circadian rhythm and metabolism. [00:05:11] Metabolism is gimped at night; Study: Bo, S., et al. "Is the timing of caloric intake associated with variation in diet-induced thermogenesis and in the metabolic pattern? A randomized cross-over study." International Journal of Obesity 39.12 (2015): 1689. [00:05:26] Meal timing and the circadian regulation of nutrient partitioning; Study: Jakubowicz, Daniela, et al. "Influences of breakfast on clock gene expression and postprandial glycemia in healthy individuals and individuals with diabetes: a randomized clinical trial." Diabetes care (2017): dc162753. [00:05:54] Studies: Jacobs, H., Thompson, M., Halberg, E., Halberg, F., Fraeber, C., Levine, H. & Haus, E. (1975) Relative body weight loss on limited free-choice meal consumed as breakfast rather than as dinner. Chronobiologia 2 (suppl 1): 33; and Hirsh, E., Halberg, F., Goetz, F.C., Cressey, D., Wendt, H., Sothern, R., Haus, E., Stoney, P., Minors, D., Rosen, G., Hill, B., Hilleren, M. & Garett, K. (1975) Body weight change during 1 week on a single daily 2000-calorie meal consumed as breakfast (B) or dinner (D). Cronobiologia 2 (suppl 1): 31–32. [00:06:40] Study: Lombardo, Mauro, et al. "Morning meal more efficient for fat loss in a 3-month lifestyle intervention." Journal of the American College of Nutrition 33.3 (2014): 198-205. [00:08:57] Study: Gasmi, Maha, et al. "Time-restricted feeding influences immune responses without compromising muscle performance in older men." Nutrition 51 (2018): 29-37. [00:10:20] Study: Gabel, Kelsey, et al. "Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study." Nutrition and Healthy Aging Preprint: 1-9. [00:12:19] Breakfast like a king, lunch like a prince, and dinner like a pauper. [00:12:30] Early Time-Restricted Feeding; Study: Sutton, Elizabeth F., et al. "Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes." Cell metabolism 27.6 (2018): 1212-1221. [00:13:56] Podcast: How to Use Time-Restricted Eating to Reverse Disease and Optimize Health, with Satchin Panda, PhD. [00:14:16] Continuous energy restriction vs. Intermittent Fasting; Study: Sundfør, T. M., M. Svendsen, and S. Tonstad. "Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial." Nutrition, Metabolism and Cardiovascular Diseases (2018). [00:15:00] Circadian rhythm disruption and disease risk. [00:16:10] Electronics at night as circadian rhythm disruption. [00:16:44] Artificial light at night and cancer; Studies: Yuan, Xia, et al. "Night shift work increases the risks of multiple primary cancers in women: a systematic review and meta-analysis of 61 articles." Cancer Epidemiology and Prevention Biomarkers 27.1 (2018): 25-40; and Kubo, Tatsuhiko, et al. "Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study." American journal of epidemiology 164.6 (2006): 549-555. [00:20:27] Chronotypes as a species-level distinction. [00:23:33] Philips goLITE BLU Energy Light. [00:24:17] Best advice for shift workers. [00:25:20] Genetic polymorphisms; MTNR gene. [00:26:38] Sleep deprivation leads to increased calorie consumption. Study: Broussard, Josiane L., et al. "Elevated ghrelin predicts food intake during experimental sleep restriction." Obesity 24.1 (2016): 132-138. [00:27:41] Sleep contributes to the maintenance of lean body mass. Study: Nedeltcheva, Arlet V., et al. "Insufficient sleep undermines dietary efforts to reduce adiposity." Annals of internal medicine 153.7 (2010): 435-441. [00:29:12] Macronutrient composition of diet. [00:29:23] Book: The Poor, Misunderstood Calorie, by William Lagakos, PhD. [00:30:12] Reduced industrial foods resulting in weight loss; Study: Ebbeling, Cara B., et al. "Effects of a low–glycemic load vs low-fat diet in obese young adults: a randomized trial." Jama 297.19 (2007): 2092-2102. [00:30:31] Calories less important when eating processed foods; Monkey study: Kavanagh, Kylie, et al. "Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys." Obesity 15.7 (2007): 1675-1684. [00:32:16] Protein intake recommendations. [00:34:44] The glucose-sparing effect of ketones. [00:35:47] Protein needed to maintain lean-muscle mass during keto. Study: Meckling, Kelly A., Caitriona O’sullivan, and Dayna Saari. "Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women." The Journal of Clinical Endocrinology & Metabolism 89.6 (2004): 2717-2723. [00:36:43] Ketogenic diets and mental health. [00:37:24] Neuroprotective properties of keto; Study: Maalouf, Marwan, Jong M. Rho, and Mark P. Mattson. "The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies." Brain research reviews 59.2 (2009): 293-315. [00:37:40] Poor adherence to keto in more severe dementia. Study: Taylor, Matthew K., et al. "Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease." Alzheimer's & Dementia: Translational Research & Clinical Interventions 4 (2018): 28-36. [00:38:02] MCT oil used to moderate cognitive decline; Study: Henderson, Samuel T., et al. "Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial." Nutrition & metabolism 6.1 (2009): 31. [00:38:39] Keto for Bipolar Disorder; Study: Phelps, James R., Susan V. Siemers, and Rif S. El-Mallakh. "The ketogenic diet for type II bipolar disorder." Neurocase 19.5 (2013): 423-426. [00:39:14] Consultation with clients. [00:41:02] Blog post on changing sleep duration: Circadian rhythms, sleep deprivation, and human performance. [00:42:21] Athletics and adaptation to ketosis. [00:43:25] Wingate test. [00:43:46] Olympic weightlifters; Study: Greene, David A., et al. "A Low-Carbohydrate Ketogenic Diet Reduces Body Mass Without Compromising Performance in Powerlifting and Olympic Weightlifting Athletes." The Journal of Strength & Conditioning Research 32.12 (2018): 3373-3382. [00:45:52] Blog; Twitter; Patreon.
Members from Team Telomere (formerly DC Outreach), a community for telomere biology disorders join me for this episode. This panel includes patient advocate Katie Stevens, Dr. Sharen Savage, and Dr. Suneet Agarwal. They provide information and support services to families worldwide who are affected by these disorders, encourage the medical community’s research in finding causes and effective treatments, and facilitate improved diagnosis by educating medical providers.Katie Stevens is the Executive Director of Team Telomere. Her oldest child, Riley, is affected by a telomere disorder. Katie’s goal is to be an advocate and resource. She is also a member of Global Genes Foundation Alliance Advisory Council and a NORD member leader.Dr. Sharon Savage is the Chief of the Clinical Genetics Branch in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute (NCI). She leads clinical, genetic, and epidemiologic studies of individuals and families at high risk of cancer. Dr. Savage’s research program in telomere molecular epidemiology incorporates population-based studies of telomere length and disease with genetic studies of telomere biology. She serves as a Medical Advisor for Team Telomere.Dr. Suneet Agarwal completed his M.D. and Ph.D. training at Harvard Medical School. He is currently an Assistant Professor in Pediatrics at Harvard Medical School, Principal Faculty at the Harvard Stem Cell Institute and Harvard Initiative in RNA Medicine, and Staff Physician in Hematopoietic Cell Transplantation at the Dana-Farber / Boston Children’s Cancer and Blood Disorders Center. Dr. Agarwal's research and clinical work is focused on the mechanisms and treatment of genetic blood disorders. He leads a multi-center bone marrow transplant clinical trial for dyskeratosis congenita, and his lab is working on new therapeutic approaches for telomere diseases. He also serves as a Medical Advisor for Team Telomere.This Episode We DiscussKatie’s Son’s Diagnostic JourneyDyskeratosis Congenita and Telomere Biology DisorderPrevalenceSymptomsAge of OnsetAssociated GenesDiagnosis ProcessTreatmentsLatest ResearchHow Team Telomere Helps Affected FamiliesBecoming a Bone Marrow Donor > BeTheMatch.orgStay tuned for the next new episode of DNA Today on November 2nd, 2018. New episodes are released on the first and third Fridays of the month. Can’t wait? There are over 90 episodes to explore in the meantime.See what else I am up to on Twitter, Instagram, Facebook and iTunes. Questions/inquiries can be sent to Kira at info@DNApodcast.com.
Dr. Satchin Panda, PhD. is a professor and researcher at the Salk Institute for Biological Studies, and a founding executive member of the Center for Circadian Biology at the University of California, San Diego. He is widely recognized as one of the world’s leading experts on circadian rhythms and has been publishing revolutionary research with a current focus on the benefits of time-restricted eating. He is also the author of The Circadian Code, a guide for optimizing health and reversing disease by living in alignment with the body’s internal clock. Dr. Panda is with Dr. Tommy Wood on the podcast today, talking about the evidence that points to the dramatic impact of meal timing and light exposure on health. They discuss the high risk of chronic disease that comes with circadian mismatch and share the most important steps you can take to mitigate the damage associated with living in a world that never sleeps. In the introduction, I mention a survey. You can answer the questions (and get a little more detail about the program with Simon Marshall) at this link: → http://survey.nbt.ai ← Here’s the outline of this interview with Satchin Panda: [00:00:37] Book: The Circadian Code, by Satchin Panda. [00:03:25] Professor at the Salk Institute for Biological Studies. [00:06:56] Joe Bass, MD, PhD. [00:07:05] Study: Kohsaka, Akira, et al. "High-fat diet disrupts behavioral and molecular circadian rhythms in mice." Cell metabolism 6.5 (2007): 414-421. [00:07:47] Study: Gill, Shubhroz, et al. "Time-restricted feeding attenuates age-related cardiac decline in Drosophila." Science 347.6227 (2015): 1265-1269. [00:10:08] Christopher Vollmers, Assistant Professor at UC Santa Cruz. [00:10:53] Different Time Restricted Feeding (TRF) windows; Study: Chaix, Amandine, et al. "Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges." Cell metabolism 20.6 (2014): 991-1005. [00:13:29] myCircadianClock; Study: Gill, Shubhroz, and Satchidananda Panda. "A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits." Cell metabolism 22.5 (2015): 789-798. [00:17:55] Endurance athletes. [00:19:10] Improved athletic performance; Study: Chaix, Amandine, et al. "Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges." Cell metabolism 20.6 (2014): 991-1005. [00:20:32] Ketone production. [00:23:13] High fat diet leads to increased ketone production, improved endurance. [00:24:24] Meal timing. [00:26:52] Consistency is important. [00:29:53] Supplements and coffee. [00:32:05] Kenneth Wright, Jr.; Night owls and morning larks Study: Wright Jr, Kenneth P., et al. "Entrainment of the human circadian clock to the natural light-dark cycle." Current Biology 23.16 (2013): 1554-1558. [00:34:05] Michael Herf; f.lux. [00:35:24] Biphasic sleep; arousal threshold. [00:39:46] Exposure to light. [00:40:33] Effect of light on skin; Study: Lindblom, Niki, et al. "Bright light exposure of a large skin area does not affect melatonin or bilirubin levels in humans." Biological psychiatry 48.11 (2000): 1098-1104. [00:41:02] Improving sleep. [00:41:22] Naps. [00:42:52] Night workers and swing shifts. [00:43:20] Studying firefighters. [00:43:28] Food timing effective for resetting circadian clock; Study: Oike, Hideaki, et al. "Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work." Biochemical and biophysical research communications 465.3 (2015): 556-561. [00:45:09] Traveling through time zones. [00:47:47] Timing of physical activity. [00:49:00] Email apnea. [00:50:00] Meal timing for prevention of cancer; Study: Kogevinas, Manolis, et al. "Effect of mistimed eating patterns on breast and prostate cancer risk (MCC‐Spain Study)." International journal of cancer (2018). More from the MCC Research Team. [00:50:34] Effect of nightly fasting on breast cancer; Study: Marinac, Catherine R., et al. "Prolonged nightly fasting and breast cancer prognosis." JAMA oncology 2.8 (2016): 1049-1055. [00:50:52] Night shift work increases women’s risk of cancer: Yuan, Xia, et al. "Night shift work increases the risks of multiple primary cancers in women: a systematic review and meta-analysis of 61 articles." Cancer Epidemiology and Prevention Biomarkers 27.1 (2018): 25-40. [00:51:03] Optimal timing of drugs; studies: Lévi, Francis, et al. "Implications of circadian clocks for the rhythmic delivery of cancer therapeutics." Advanced drug delivery reviews 59.9-10 (2007): 1015-1035; and Lauriola, Mattia, et al. "Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment." Nature communications 5 (2014): 5073. [00:52:14] Lifestyle: what, when and how much we eat, sleep, and move. [00:53:40] Book: The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight, by Valter Longo, PhD. [00:55:43] Architecture Study: Dance, Amber. "Science and Culture: The brain within buildings." Proceedings of the National Academy of Sciences 114.5 (2017): 785-787. [00:56:44] Benefits of daylight in architecture; Study: Boubekri, Mohamed, et al. "Impact of windows and daylight exposure on overall health and sleep quality of office workers: a case-control pilot study." Journal of clinical sleep medicine 10.06 (2014): 603-611; and Daylighting Facts & Figures. [00:59:29] 30 minutes of bright light in the morning. [01:00:51] Recommendations: 8 hours sleep, wait to eat breakfast, eat within 10 hours; 30 minutes of bright light, dim light/no food 3 hours before bed. [01:01:46] mycircadianclock.org; myLuxRecorder app.
The Staying Young Show 2.0 - Entertaining | Educational | Health & Wellness
A Chinese study released in the journal Cancer Epidemiology, Biomarkers & Prevention showed that women who work the night shift, or irregular hours are one fifth more likely to develop cancers, particularly skin, breast, and lung cancers. This is significant for US residents because according to the CDC as many as 15 million of our workers work the night shift. We already know from other studies that the night shift is linked to increased risk of obesity, diabetes, and heart disease because it significantly disrupts the body's circadian rhythm, or internal clock. Now before you say that the research was only applied to Chinese people, you need to know that the research team looked at over 3.9 Million participants and more than 114,000 cancer cases. The patient demographic varied as participants were from Asia, Australia, Europe, and North America. This just goes to show how important Good quality sleep is. This Stay Young Medical Minute is brought to you by Executive Medicine of Texas a global leader in preventative and proactive healthcare. Visit EMTexas.com or call 800-910-EXEC That's EMTexas.com or 800-910- E-X-E-C. Thank you for listening to the Staying Young Medical Minute! With all the mixed messages on health, you need information that you can use and that you can trust. Listen in as the experts discuss all topics health related. It's time to STAY YOUNG and stay healthy! Each week we tackle a topic and often with leading scientists, best-selling authors, and even your favorite celebrities! As a listener of our show, your input is important to us. Please take a moment to fill out this quick survey so we can serve you better - Survey For more information on The Staying Young Show, please visit our website, and subscribe to the show in iTunes, Stitcher, or your favorite podcast app. You can also reach out to our host, Judy Gaman, here for book purchasing, and speaking opportunities in your area!
Creating a Family: Talk about Infertility, Adoption & Foster Care
Host Dawn Davenport, Executive Director of Creating a Family, the national infertility & adoption education and support nonprofit, interviews Dr. Louise Brinton, Senior Scientific Advisor for the Division of Cancer Epidemiology and Genetics of the National Cancer Institute (NCI). During her 40 year career with the NCI, she has focused her research on a wide variety of exposures related to cancer risks among women, including reproductive factors and fertility drugs; Humberto “Bert” Scoccia, MD, Professor and Director of the Division of Reproductive Endocrinology and Infertility in the Department of Obstetrics and Gynecology at the University of Illinois College of Medicine in Chicago; and Alice Crisci, breast cancer survivor, activist and author. Creating a Family has many free resources related to this topic on our website at www.CreatingaFamily.org. Please leave us a review on iTunes. Thanks. Click to Tweet: http://ctt.ec/b8ej6 Facebook Share: https://www.facebook.com/sharer/sharer.php?u=https%3A//creatingafamily.org/infertility-category/infertility-treatment-breastovarian-cancer/ Show Highlights: https://creatingafamily.org/infertility-category/infertility-treatment-breastovarian-cancer/ Support the show (https://creatingafamily.org/donation/)
I continue to be horrified by guidelines issued by the American Heart Association and American College of Cardiology, which speak of giving statin drugs to healthy people. Meanwhile, draft recommendations from the US Preventive Task Force have issued new directives claiming that healthy people should be taking statin drugs as a “preventative against possible future illness.” Their main plan is to see one third of all adults in the United States are put on statin drugs—44% of all men and 22% of all women—even if none of these people have ever had a previous heart attack or stroke. Statins are the most widely prescribed drugs on the market. One in four Americans over 45 are already on statins, despite more than 900 studies reporting dangerous side effects from these drugs. These range from heightened risks of cancer and diabetes to sexual problems, neuropathy, and liver dysfunction, as well as immune system suppression, and even a higher risk of cataracts. In Britain too, statins are the most commonly prescribed drugs, costing the NMS £450 million a year. Now 40% of adults (175 million people) are being advised to take the drug. If the new directives are put into practice by the UK medical establishment—as they are likely to be—the numbers of men and women being prescribed statins could well become legion. What are statins anyway? Statins are a group of drugs prescribed to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Statins have many different names, such as Lipitor, Lescol, Mevacor, Altocor, and Zocor. These drugs are prescribed on the assumption that they will lower the risks of cardiovascular events and strokes. The new directives assert that, if given to healthy people, they could help protect the population from heart attacks and strokes at some time in the future. Happily, a growing number of cardiologists are strongly opposed to the new directives. What’s the problem with statins? Plenty: They deplete your body of CoQ10, which is essential for every cell in your body, and ubiquinol. Both CoQ10 and ubiquinol keep the so-called bad cholesterol from doing harm to your body. However, very few mainstream doctors are ever aware of these dangers. One exception is cardiologist Steven Sinatra, founder of the New England Heart Center. Sinatra recommends that anyone taking statins should take between 100 and 200 mg of CoQ10 or ubiquinol each day as protection. Statins lower Vitamin K2 in the body. This puts you at risk of deficiency of this vitamin, which contributes to chronic diseases, such as osteoporosis, cancer, and brain disease. Long-term statin use—10 years or so—has been shown to increase your risk of diabetes, neurogenerative diseases, musculoskeletal problems, and even cataracts. Dr. Eric Topol, highly respected cardiologist and Professor of Genomics at Scripps Research Institute in California, wrote an excellent article for The New York Times Opinion Page in which he warns: “We’re overdosing on cholesterol-lowering statins.” Topol is especially concerned about the sharp increase in the prevalence of Type 2 Diabetes that is occurring in people using them. He writes: “Statins have been available since the 1980s but their risk of inducing diabetes did not surface for nearly 20 years. When all the data available from multiple studies was pooled in 2010 for more than 91,000 patients randomly assigned to be treated with a statin or a sugar pill (placebo), the risk of developing diabetes with any statin was one in every 255 patients treated. But this figure is misleading since it includes weaker statins like Pravachol and Mevacor—which were introduced earlier and do not carry any clear-cut risk. It is only with the more potent statins—Zocor (now known as simvastatin), Lipitor (atorvastatin), and Crestor (rosuvastatin)—particularly at higher doses—that the risk of diabetes shows up. The cause and effect was unequivocal because the multiple large trials of the more potent statins had a consistent excess of diabetes.” Meanwhile, a recent study by Jean A. McDougall and her colleagues in the Journal of Cancer Epidemiology, Biomarkers & Prevention reveals that long-term use of statins increases the risk of both lobular and ductal breast cancer in women between 55 and 74. I am no doctor, but what I have learned during my more than forty years of writing and broadcasting on health is this: When a body is restored to healthy functioning naturally, the need for medication is either dramatically reduced or, more often than not, eliminated altogether. Statins, like most pharmaceuticals, only mask symptoms—they do not heal. Only nature can heal from within. My advice to anyone thinking of accepting the new directives is this: Before you agree to take statins, research the implications of doing so. Learn as much as you can about statin drugs. There are excellent natural alternatives, such as inexpensive dietary changes. So, if your doctor wants to prescribe statins for you, you can be sure you have done your homework. Then you’ll know yourself if these drugs are appropriate for you. Chances are they are not. Here are a few recommendations for where to start your research: U-T San Diego “Doctors assail new guidelines for statins: 18 November, 2013 Cancer Epidemiology, Biomarkers & Prevention; Published Online First July 5, 2013; doi: 10.1158/1055-9965.EPI-13-0414 http://www.greenmedinfo.com/toxic-ingredient/statin-drugs. This is an excellent compilation of dangers from statin drugs, with links to abstracts. www.ncbi.nlm.nih.gov/pubmed/24052188 Association of statin use with cataracts: a propensity score-matched analysis. This is a good source of information on the use of statins for the elderly. A. Sultan and N. Hynes, "The Ugly Side of Statins. Systemic Appraisal of the Contemporary Un-Known Unknowns," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 3, 2013, pp. 179-185. doi: 10.4236/ojemd.2013.33025.
I continue to be horrified by guidelines issued by the American Heart Association and American College of Cardiology, which speak of giving statin drugs to healthy people. Meanwhile, draft recommendations from the US Preventive Task Force have issued new directives claiming that healthy people should be taking statin drugs as a “preventative against possible future illness.” Their main plan is to see one third of all adults in the United States are put on statin drugs—44% of all men and 22% of all women—even if none of these people have ever had a previous heart attack or stroke. Statins are the most widely prescribed drugs on the market. One in four Americans over 45 are already on statins, despite more than 900 studies reporting dangerous side effects from these drugs. These range from heightened risks of cancer and diabetes to sexual problems, neuropathy, and liver dysfunction, as well as immune system suppression, and even a higher risk of cataracts. In Britain too, statins are the most commonly prescribed drugs, costing the NMS £450 million a year. Now 40% of adults (175 million people) are being advised to take the drug. If the new directives are put into practice by the UK medical establishment—as they are likely to be—the numbers of men and women being prescribed statins could well become legion. What are statins anyway? Statins are a group of drugs prescribed to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Statins have many different names, such as Lipitor, Lescol, Mevacor, Altocor, and Zocor. These drugs are prescribed on the assumption that they will lower the risks of cardiovascular events and strokes. The new directives assert that, if given to healthy people, they could help protect the population from heart attacks and strokes at some time in the future. Happily, a growing number of cardiologists are strongly opposed to the new directives. What’s the problem with statins? Plenty: They deplete your body of CoQ10, which is essential for every cell in your body, and ubiquinol. Both CoQ10 and ubiquinol keep the so-called bad cholesterol from doing harm to your body. However, very few mainstream doctors are ever aware of these dangers. One exception is cardiologist Steven Sinatra, founder of the New England Heart Center. Sinatra recommends that anyone taking statins should take between 100 and 200 mg of CoQ10 or ubiquinol each day as protection. Statins lower Vitamin K2 in the body. This puts you at risk of deficiency of this vitamin, which contributes to chronic diseases, such as osteoporosis, cancer, and brain disease. Long-term statin use—10 years or so—has been shown to increase your risk of diabetes, neurogenerative diseases, musculoskeletal problems, and even cataracts. Dr. Eric Topol, highly respected cardiologist and Professor of Genomics at Scripps Research Institute in California, wrote an excellent article for The New York Times Opinion Page in which he warns: “We’re overdosing on cholesterol-lowering statins.” Topol is especially concerned about the sharp increase in the prevalence of Type 2 Diabetes that is occurring in people using them. He writes: “Statins have been available since the 1980s but their risk of inducing diabetes did not surface for nearly 20 years. When all the data available from multiple studies was pooled in 2010 for more than 91,000 patients randomly assigned to be treated with a statin or a sugar pill (placebo), the risk of developing diabetes with any statin was one in every 255 patients treated. But this figure is misleading since it includes weaker statins like Pravachol and Mevacor—which were introduced earlier and do not carry any clear-cut risk. It is only with the more potent statins—Zocor (now known as simvastatin), Lipitor (atorvastatin), and Crestor (rosuvastatin)—particularly at higher doses—that the risk of diabetes shows up. The cause and effect was unequivocal because the multiple large trials of the more potent statins had a consistent excess of diabetes.” Meanwhile, a recent study by Jean A. McDougall and her colleagues in the Journal of Cancer Epidemiology, Biomarkers & Prevention reveals that long-term use of statins increases the risk of both lobular and ductal breast cancer in women between 55 and 74. I am no doctor, but what I have learned during my more than forty years of writing and broadcasting on health is this: When a body is restored to healthy functioning naturally, the need for medication is either dramatically reduced or, more often than not, eliminated altogether. Statins, like most pharmaceuticals, only mask symptoms—they do not heal. Only nature can heal from within. My advice to anyone thinking of accepting the new directives is this: Before you agree to take statins, research the implications of doing so. Learn as much as you can about statin drugs. There are excellent natural alternatives, such as inexpensive dietary changes. So, if your doctor wants to prescribe statins for you, you can be sure you have done your homework. Then you’ll know yourself if these drugs are appropriate for you. Chances are they are not. Here are a few recommendations for where to start your research: U-T San Diego “Doctors assail new guidelines for statins: 18 November, 2013 Cancer Epidemiology, Biomarkers & Prevention; Published Online First July 5, 2013; doi: 10.1158/1055-9965.EPI-13-0414 http://www.greenmedinfo.com/toxic-ingredient/statin-drugs. This is an excellent compilation of dangers from statin drugs, with links to abstracts. www.ncbi.nlm.nih.gov/pubmed/24052188 Association of statin use with cataracts: a propensity score-matched analysis. This is a good source of information on the use of statins for the elderly. A. Sultan and N. Hynes, "The Ugly Side of Statins. Systemic Appraisal of the Contemporary Un-Known Unknowns," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 3, 2013, pp. 179-185. doi: 10.4236/ojemd.2013.33025.
Kristina R. Dahlstrom, Ph.D. Instructor, Head and Neck Surgery The University of Texas MD Anderson Cancer Center
What’s New in Cancer Epidemiology? with guest Dr. Yawei Zhang April 6, 2014 Yale Cancer Center visit: http://www.yalecancercenter.org email: canceranswers@yale.edu call: 203-785-4095
Dr Evi Farazi talks to ecancer at the 2013 National Cancer Institute Directors Meeting (NCID 2013) in Lyon about epidemiology in Cyprus and the difficulties of securing funding.
October is "pink" month (breast cancer awareness) and I review a recent report (published in the July 2010 issue of Cancer Epidemiology, Biomarkers & Prevention) that suggests that fish oil may reduce ductal breast cancer (not lobular). So start eating fish! The second report is a study in which scientists in Hong Kong and Australia report how different body measurements correspond to female attractiveness. The study was published in the Journal of Evolutionary Biology and found that young, tall and long armed women are considered to be the most attractive.
People who drink at least two sugary sodas a week have an increased risk of developing cancer of the pancreas, and researchers suspect the culprit is sugar, a new study shows (http://www.google.com/hostednews/afp/article/ALeqM5jO0U3xAAFv0enNhVWgYTIEe5jo0A). Analyses of data collected on 60,524 Singapore Chinese adults showed that people who drank two or more sugar-sweetened soft drinks a week were at greater risk of developing pancreatic cancer compared with individuals who did not, the study published in Cancer Epidemiology, Biomarkers and Prevention says. No link was found between drinking juice and pancreatic cancer, which is one of the most rapidly fatal cancers in adults, with less than five percent of patients surviving five years or more after being diagnosed with the illness. The study was the first to look at the role fizzy drinks and juice play in the development of pancreatic cancer in Asians, whose diet and lifestyle are becoming more and more Western, the study says. Previous studies had looked at Europeans and Americans. Each week Martin Pytela and Scott Paton discuss Holistic principles for healthy living. Life Enthusiast Co-op is built on over 25 years in study, health consultations and market research in the field of holistic and alternative medicine. We deliver solid time tested expertise. We are in this business not for the money, but for the passion, we have for sharing with others what we had to learn the hard way, through experience. We focus on high quality, innovative holistic solutions. Length: 32:27 Go to iTunes and review our podcast: iTunes Life Enthusiast Reviews and 5 star ratings If You Enjoyed This, Please Go To "FANS OF THIS SHOW" On The RIGHT And Then Click On "BECOME A FAN". In Addition, PLEASE CLICK On The “SEND TO A FRIEND” At The Bottom Of This Podcast…. COPY THE DATA And SEND THIS, and “My Pod Home Page URL”, To EVERYONE In Your ADDRESS BOOK…. FRIENDS Or ENEMIES! WANT TO BE NOTIFIED OF NEW EPISODES? ~~~~~~~~~~~~~~~~~~~~ Go To “Join my mailing list ” On The RIGHT………. When It Comes Up You Will See On This Page “Add me to Life Enthusiast''s mailing list:” ………. And Then type in your name and email address ………. Now Just Click “Save”. Technorati Tags: weight loss, Diet, Obesity, Dieting, Healthy Living,Food, Exercise, Fitness, Nutrition, Supplements, Lose Weight, Martin Pytela, Scott Paton.
John Cannaday, M.D., a staff radiologist at Cooper Clinic discusses two studies reported in the December issue of the Archives of Internal Medicine, calling on physicians to limit CT Scans due to the risks associated with radiation exposure. The study headline read "Commonly performed CT scans are exposing patients to far more radiation than previously thought and in doses that could cause tens of thousands of cancers a year." In the two studies, the authors call on physicians to limit radiation exposure to patients. Dr. Cannaday reports that CT scans are used regularly at Cooper Clinic as a tool in evaluating cardiovascular health, and diagnosing coronary artery disease and blockage. The technology over the past decade has dramatically improved - through CT scans it's possible to take a noninvasive three dimensional tour of the torso. In the first study, a team (lead by Dr. Rebecca Smith-Bindman) at the University of California, San Francisco, collected data from 1,119 patients who received 11 types of CT scans in four area hospitals. The level of radiation exposure in the CT scans varied widely within and across the hospitals, with an average variation that was 13-fold. For example, the dose of radiation for a multiphase abdomen-pelvis CT scan ranged from 6 to 90 millisieverts, with an average dose of 31 millisieverts. In the second study, Amy Berrington de Gonzalez and her team (from the National Cancer Institute's Division of Cancer Epidemiology and Genetics) estimated that 29,000 future cancers could be related to scans performed in 2007, and that these cases could result in about 14,500 deaths. From a consumer standpoint, the more exposure we have to radiation, the higher the potential risk of cancer. Dr. Cannaday says that we are not able to free ourselves from radiation, the average background radiation is 3 millisieverts. Scan ranges less than 100 millisieverts are considered low exposures. The team at the Cooper Clinic have aggressively trained to run these tests with the lowest possible exposure possible. The average exposure for a multiple slice of the heart to look for calcium scoring is approximately .9 millisieverts, so less than 1 millisievert. For the coronary CT antiogram which is a more extensive test, Cooper Clinic routinely performs this test with a millisieverts score of 2 or less. The test is more involved when looking at coronary bypass patients, and Cooper Clinic performs this test for 2.5 millisieverts or less. Dr. Cannaday believes patients should talk with their physician about the radiation exposure of any test, and to ascertain if there are alternative ways to get the results without non-ionizing radiation, for example through MRI or ultra sound. Any exam in the imaging department needs to be tailored to the question being asked, and minimizing radiation exposure should be a consideration. Patients need to keep in mind that scans are a tremendous tool in diagnosing cardiovascular, abdominal, chest and head diseases. While we need to be aware of radiation exposure, Dr. Cannaday hopes that studies like these don't scare people away from having tests they may genuinely need for managing their overall health. ReferenceStudies Quantify Cancer Risks From CT Scans Jill Turner is VP of Operations for Cooper Concepts, the company that markets Cooper Complete nutritional supplements, and oversees the Cooper Wellness Program, where individuals come to live at Cooper for a week at a time to focus on living a healthy life. Jill regularly contributes information to the Cooper blog. Email jsturner@cooperwellness.com or call 972-560-3262 with your questions and comments.
Although childhood leukemia is the most common childhood cancer, little is known about its causes. Incidence of acute lymphocytic leukemia, the most common childhood leukemia, is highest in industrialized countries and rose significantly between 1975 and 2004, suggesting environmental agents may play some role. In this podcast, Mary H. Ward explores the idea that polychlorinated biphenyls (PCBs) could be one such agent. Ward is the lead author of "Residential Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides and Risk of Childhood Leukemia" and a senior investigator in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Bethesda, Maryland. Visit the podcast webpage to download a full transcript of this podcast.
Guest: Andrew Flood, PhD Host: Gary Kohn, MD The risk association between diabetes and colorectal cancer: what is the mechanism driving the correlation? What methods are used to study the relationship? Dr. Andrew Flood, assistant professor of epidemiology, University of Minnesota, and adjunct investigator at the National Cancer Institute, Division of Cancer Epidemiology and Genetics discusses the relationship and his research with host Dr. Gary Kohn.
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