Podcasts about rer

durée : 00:09:52 - La Question du jour - par : Julie Gacon - Alors que les travaux sur la ligne du RER B ont duré trois jours en bloquant totalement la desserte nord parisienne, la Question du jour s'interroge sur les répercutions d'une amélioration du trafic pour les populations desservies. Un RER B amélioré leur sera-t-il uniquement bénéfique ? - invités : Frédéric Gilli Chercheur associé au Centre d'Etudes européennes de Sciences-po et directeur associé de l'agence Campana Eleb Sablic

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.25.550497v1?rss=1 Authors: Avila-Gutierrez, K., Slaoui, L., Alvear, R., Kozlowski, E., Oudart, M. F., Augustin, E., Mailly, P., Monnet, H., Mignon, V., Saubamea, B., Boulay, A.-C., Cohen-Salmon, M. Abstract: Astrocytes (the main glial cells in the brain) are highly ramified and send out perivascular processes (PvAPs) that entirely sheathe the brain s blood vessels. PvAPs are equipped with an enriched molecular repertoire that sustains astrocytic regulatory functions at the vascular interface. In the mouse, PvAP development starts after birth and is essentially complete by postnatal day (P) 15. Progressive molecular maturation also occurs over this period, with the acquisition of proteins enriched in PvAPs. The mechanisms controlling the development and molecular maturation of PvAPs have not been extensively characterized. We reported previously that mRNAs are distributed unequally in mature PvAPs and are locally translated. Since dynamic mRNA distribution and local translation influence the cell s polarity, we hypothesized that they might sustain the postnatal maturation of PvAPs. Here, we used a combination of molecular biology and imaging approaches to demonstrate that the development of PvAPs is accompanied by the transport of mRNA and polysomal mRNA into PvAPs, the development of a rough endoplasmic reticulum (RER) network and Golgi cisternae, and local translation. By focusing on genes and proteins that are selectively or specifically expressed in astrocytes, we characterized the developmental profile of mRNAs, polysomal mRNAs and proteins in PvAPs from P5 to P60. Furthermore, we found that distribution of mRNAs in PvAPs is perturbed in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts. Lastly, we found that some polysomal mRNAs polarized progressively towards the PvAPs. Our results indicate that dynamic mRNA distribution and local translation influence the postnatal maturation of PvAPs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Quoi de mieux qu'un Podcazine pour clôturer cette saison légendaire du Troisième Lieu ? En guise de clap de fin de cette saison 6, les étudiants ont rassemblés un casting XXL avec les meilleurs chroniques et chroniqueurs jamais réunis ! (stat à vérifier) Certains font leur apparition, d'autres leurs adieux mais peu importe, le plus important c'est que vous puissiez écouter Le Troisième Lieu pour partir à Punta Cana cet été mais surtout que cette belle radio continue de vivre. Alors, de la part de toute la rédaction, bonnes vacances mais surtout, bonne écoute ! Programmes : (00:38) – Introduction par Dylan et Théo (2:20) – Oumar et sa chronique sur SLAM DUNK, la référence du manga basket (5:24) – Justine nous aide à comprendre pourquoi, le sport et la politique sont liés (10:44) – Thomas revient sur l'hypothèse d'un projet de RER urbain à Lyon, Dylan vient même lui donner la réplique(15:37) – Justine revient pour nous parler sport et politique avec l'épisode historique de “La guerre du football” entre le Salvador et le Honduras(20:17) – La Fédération Française de la Lose ou l'art de perdre à la française par Axel et Dylan (26:26) – Outro, Théo et Dylan nous font un dernier au revoir plein d'émotions

Debbie and Latt Mansor sat down again to dive into research on how, when and why to use Ketone IQ to improve performance and recovery. Check out the recently published a paper on metabolic psychiatry: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142682/full and our research partners at one of America's largest senior military colleges (University of North Georgia) recently completed and submitted a study on Ketone-IQ for anaerobic exercise. I would love to be talk about these with you on a new episode on your podcast, since it is the first time in history that a study actually uses exogenous ketones for anaerobic exercise. Overview and link to pre public manuscript below: METABOLIC EFFECTS OF R-1,3-BUTANEDIOL (KETONE-IQ) DURING AEROBIC AND ANAEROBIC EXERCISE BOUTS. A new Ketone-IQ research study was recently completed at a top US senior military university (University of North Georgia) — The study has been submitted to Frontiers in Physiology as of March 30, 2023 and currently under review. The findings showed supplementation of Ketone-IQ significantly increases blood ketones and significantly improves anaerobic performance while decreasing fatigue levels on a repeated cycle ergometer. The potential mechanism may include glycogen sparing effect which has already previously been show in studies with exogenous ketones but the more novel hypothesis could be the cognitive benefit that Ketone-IQ is providing the participants to have a significant effect on mental resilience and strength For the first time ever, exogenous ketones were used as a nutritional strategy to assess its effects on anaerobic exercise since all the performance studies in the past using exogenous ketones have been focused on endurance exercise. Ketone-IQ shifts metabolism towards fats as shown by respiratory exchange ratio (RER) in both 5 km aerobic exercise and anaerobic bouts of exercise. Ketone-IQ taken together with carbs have shown to increase anaerobic average power output, peak power output and velocity in the Wingate Anaerobic Test. Ketone-IQ has also shown decrease fatigue during anaerobic exercise. Latt Mansor, DPhil Research Lead, HVMN Health Via Modern Nutrition Inc Check out links and save with our code LOWCARBATHLETE at check out! HVMN Recovery Protocol HERE https://debbiepotts.net/should-you-use-hvmn-ketone-iq/ https://debbiepotts.net/ketone-iq-shots-how-to-use-them-and-why/ Watch our video and more here- HIT Subscribe on our YOUTUBE CHANNEL   

C'est une trouvaille exceptionnelle. Une nécropole gallo-romaine du IIe siècle a été découverte dans le 14e arrondissement de Paris, en amont des travaux pour le RER B. Depuis le 6 mars 2023, ce groupement de sépultures non rattaché à un lieu de culte est l'objet de fouilles archéologiques. Cette nécropole gallo-romaine serait la plus grande de la ville de Lutèce, au IIe siècle après JC. Pour en parler, Virginie Girod reçoit Camille Colonna, archéologue, responsable des recherches archéologiques et anthropologue à l'Institut national de recherches archéologiques préventives (l'INRAP). "Cette petite parcelle n'a pas été touchée par la construction du RER, ni par les constructions d'Haussmann, donc c'est vraiment un petit miracle", présente l'archéologue. Au total, une cinquantaine de sépultures ont été trouvées, accompagnées d'offrandes, comme des céramiques. Si l'on sait que la nécropole date du IIe avant JC, c'est notamment grâce à une pièce retrouvée dans la bouche d'un squelette, "la pièce du passeur". Cette dernière servait au défunt à payer "Charon", le passeur des Enfers, afin que leurs âmes traversent le fleuve des enfers. Selon les archéologues, ces inhumations étaient dans des cercueils. Pourtant, ils n'ont pas retrouvé de trace de bois : "Mais nous avons trouvé tous les clous qui ont servi à fabriquer les cercueils, et qui sont encore en place", explique Camille Colonna. Ces découvertes ont été réalisées alors que le site avait déjà été fouillé à l'époque des travaux d'urbanisation d'Haussmann, au XIXe siècle : "Ils ne fouillaient pas du tout comme nous. Ils ramassaient les beaux objets, mais ne regardaient pas les modes d'inhumation. Il n'y avait pas toute l'anthropologie et l'archéologie qu'on fait maintenant", ajoute l'archéologue.Sujets abordés : Fouilles - Archéologie - Antiquité - Nécropole - Sépultures  "Au cœur de l'histoire" est un podcast Europe 1 Studio. Ecriture et présentation : Virginie Girod - Production : Europe 1 Studio- Direction artistique : Adèle Humbert et Julien Tharaud - Réalisation : Clément Ibrahim - Musique originale : Julien Tharaud - Musiques additionnelles : Julien Tharaud et Sébastien Guidis - Communication : Kelly Decroix - Visuel : Sidonie Mangin  

Il podcast è stato creato da Michele Bedani, Niccolò Diamanti e Manpreet Singh, studenti del Liceo Attilio Bertolucci di Parma. La realizzazione è avvenuta all'interno del percorso di formazione finanziato dalla Regione Emilia-Romagna (2022-18448/RER) gestito dall'ente di formazione Irecoop in collaborazione con l'educatore Luigi Cirelli e i professori del Liceo A. Bertolucci.

La patience est essentielle à la rééducation. Le film Patients fait le récit d'une année de rééducation de Ben, dit Grand Corps Malade, qu'un accident a rendu tétraplégique partiel. Ensemble, le slameur et ses co-patients du centre de rééducation vont résister, se vanner, se séduire et trouver l'énergie pour réapprendre à vivre.Comment se passe la rééducation après des traumatismes crâniens ou médullaires ? Comment la recherche progresse-t-elle dans ce domaine ? Ces dernières années, nos sociétés ont-elles gagné en inclusivité pour les personnes en situation de handicap ?Intervenante : Pascale Pradat-Diehl, professeure émérite des universités en médecine physique de réadaptation à la faculté de médecine de Sorbonne Université, praticien hospitalier et ancienne cheffe du service de médecine physique et réadaptation de l'Hôpital de la Pitié SalpêtrièreRéférence : Patients (Mehdi Idir, Grand Corps Malade, 2017)Crédits : 7e Science est un podcast de Sorbonne Université et Binge Audio animé par Perrine Quennesson. Réalisation : Paul Bertiaux. Musique : Alexandre Delmaere. Identité graphique : Upian. ÉQUIPE BINGE AUDIO : Production et édition : Albane Fily. Direction de projet : Soraya Kerchaoui-Matignon. Direction des programme : Joël Ronez. Direction de la rédaction : David Carzon. Direction générale : Gabrielle Boeri-Charles. ÉQUIPE SORBONNE UNIVERSITÉ : Véronique Atger et Virginie Thibaud. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

durée : 00:28:15 - Les Pieds sur terre - par : Sonia Kronlund - Yussef, Mina et Zinedine travaillent dans les couloirs du RER et du métro Charles de Gaulle Etoile. IIs vendent des fruits et légumes, des sacs, des journaux aux employés pressés qui passent devant leurs échoppes avant de rejoindre leurs bureaux parisiens. La plupart sont « bac plus 5 »…

本日新聞重點：

Ngày 02/04/2023, người dân Paris đã đi bỏ phiếu về giải pháp cấm dịch vụ cho thuê xe trượt hai bánh chạy bằng điện, với kết quả là gần 90% ủng hộ cấm dịch vụ trottinette điện. Cuộc bỏ phiếu lấy ý kiến công dân được tổ chức theo sáng kiến của chính đô trưởng Paris, Anne Hidalgo. 3 nhà khai thác - 15.000 xe - 40.000 khách/thángCác hãng Lime (Mỹ), Tier (Đức) và Dott (Pháp - Hà Lan) chia sẻ thị trường dịch vụ cho thuê trottinette điện ở Paris biết rằng cuộc bỏ phiếu không được thực hiện trực tuyến nên khó thu hút giới trẻ, trái lại giới trung niên, người cao tuổi sẽ là nhóm tích cực đi bỏ phiếu nhất, nên đối tượng được các công ty tư nhân này nhắm đến vận động chủ yếu là giới trẻ, khách hàng chính của các hãng (70% khách hàng của Dott ở độ tuổi 18-35). Sau khi chính quyền Paris thông báo tổ chức bỏ phiếu lấy ý kiến công dân, ba nhà thầu dịch vụ cho thuê trotinette điện đã đầu tư vào một chiến dịch vận động lớn qua thư điện tử, trên các mạng xã hội như Facebook, Snapchat và Instagram với hashtag #SauveTaTrot (Hãy cứu trottinette của bạn), lập trang web « trottinonsmieux.com » (Hãy chạy trottinette tốt hơn) …Họ cũng tài trợ để những người có ảnh hưởng lớn trên các mạng xã hội đăng tải các video thu hút sự ủng hộ của giới trẻ đối với trotinette điện, vận động họ đi bỏ phiếu ủng hộ việc duy trì dịch vụ ở Paris. Tuy nhiên, cuộc vận động dường như không mang lại kết quả theo ý muốn của Lime, Tier và Dott. Cho dù chỉ có khoảng 100.000 người dân Paris trên tổng số dân khoảng 1,3 triệu (gần 8% dân số Paris) đi bỏ phiếu, nhưng đô trưởng thuộc đảng Xã Hội đã hứa tôn trọng ý kiến người dân, nên theo thông báo của bà sau khi có kết quả bỏ phiếu hôm 02/04, từ ngày 01/09 tới đây, 15.000 xe trượt hai bánh chạy bằng điện mà các hãng Lime (Mỹ), Tier (Đức) và Dott (Pháp - Hà Lan) khai thác sẽ không được phép lưu thông trên đường phố Paris nữa : hợp đồng chính quyền thành phố ký với 3 hãng dịch vụ tư nhân hết hạn vào ngày 31/08. Cần nói rõ là biện pháp trên chỉ có hiệu lực đối với dịch vụ cho thuê trottinette điện, chứ không liên quan đến việc người dân sử dụng trotinette cá nhân. Sau khi « cơn bão » dịch vụ cho thuê trottinette điện ồ ạt « đổ bộ » vào Paris hồi năm 2018, trotinette điện đã trở thành một trong những phương thức đi lại được nhiều người, nhất là giới trẻ, ưa chuộng vì khá tiện lợi, mà chi phí không quá cao. Thế nhưng, đâu là những lý do thúc đẩy chính quyền của đô trưởng Anne Hidalgo muốn cấm dịch vụ ? Trong khi đó, theo France Info, 15.000 trottinette điện và 400.000 người sử dụng mỗi tháng đã cho phép 3 hãng duy trì được 800 việc làm tại Paris. Còn theo Le Figaro ngày 02/04, tổng cộng cả 3 hãng đóng góp cho thành phố 930.000 euro/năm. Người bênh, kẻ chốngĐài RFI tiếng Pháp, ngày 31/03, hai hôm trước khi diễn ra cuộc bỏ phiếu lấy ý kiến công dân ở thành phố Paris, phát phóng sự của nhà báo Emma Garboud-Lorenzoni :« Bà Anne-Caroline Nakova là một nghệ sĩ vĩ cầm. Trong nhiều tháng, bà không thể đi chơi hay làm việc sau vụ bị xe trottinette điện tông vào. Bà kể lại : « Tôi đang trên đường trở về nhà để làm việc thì bị một cú tông mạnh vào lưng và ngã xuống đất, tôi không thể tưởng tượng là khi đó vỉa hè phía sau tôi có người, vấn đề là khi đó đã tôi không nghe thấy tiếng động nào hết ». Chủ Nhật, bà Anne-Caroline sẽ bỏ phiếu chống lại việc tiếp tục duy trì dịch vụ cho thuê xe trottinette điện. Về phần mình, cô Sophie Gauthier, một sinh viên người Paris, hy vọng rằng sẽ không có gì thay đổi. Cô chia sẻ : « Thực ra, xe trượt hai bánh chạy điện cho phép người ta vừa di chuyển, vừa như đang dạo chơi, chi phí lại không quá đắt, và rất tiện lợi, trong khi tôi không có bằng lái xe hơi ». Đối với ông David Belliard, quan chức tòa thị chính Paris, chuyên trách việc đi lại và không gian công cộng, thì tình hình đã có những chuyển biến theo hướng tích cực. Ông nói : « Hồi trước, có đến 12 hãng cung cấp dịch vụ cho thuê trottinette điện, xe đỗ khắp nơi, khiến thành phố trông rất tạm bợ, thiếu quy củ. Nhưng từ năm 2020, đã có các quy định cho phép chúng tôi điều chỉnh dịch vụ cho thuê xe trottinette điện. Tuy nhiên, chúng tôi vẫn còn nhiều khó khăn, đó là những vấn đề do xe để bừa bãi, gây vướng víu ở không gian công cộng, những vấn đề về an toàn : số vụ tai nạn đã tăng đáng kể, và tất nhiên là mọi người cũng có thể đặt ra những câu hỏi về môi trường ».Ông David Belliard đã bày tỏ rõ ràng sự phản đối dịch vụ cho thuê trottinette điện ở thủ đô Paris. Ông không phải là người duy nhất đi vận động mọi người bỏ phiếu. Hồi đầu tháng 3, công ty Lime cung cấp dịch vụ cho thuê trottinette điện đã khuyến mại, cho những ai trình giấy xác nhận đã đăng ký danh sách cử tri đi bỏ phiếu ở Paris được dùng dịch vụ miễn phí trong một số phút. Tổng giám đốc của hãng Lime, chi nhánh Pháp, Hadi Karam biện minh cho ý tưởng nói trên : Bảo đảm sự yên ổn ở không gian công cộng cũng là ưu tiên hàng đầu của chúng tôi, nhưng rất tiếc là các điều kiện bỏ phiếu lại bị hạn chế, người dân sống ở vùng Ile-de-France (Paris và các vùng phụ cận) không được tham gia, chỉ có người dân nội đô Paris mới được bỏ phiếu, trong khi chúng tôi biết rõ là nhiều người dân sống ở vùng ngoại ô sử dụng dịch vụ của chúng tôi ».Dẫu sao đi chăng nữa, việc làm quen với các phương tiện di chuyển mới này cũng không phải là dễ. Bà Anne-Caroline Nakova vẫn bị ám ảnh về vụ tai nạn đã xảy ra. Bà nói : « Khi tôi đi ra ngoài đường, khi tôi gặp người đi xe trượt hai bánh chạy bằng điện hay xe đạp, thì chỉ có Chúa mà biết chuyện gì sẽ xảy ra. Tôi vẫn có phản xạ ngoái lại nhìn phía sau, nhưng thực sự thấy rất khó đối phó ». Sự vô ý thức của nhiều người đi xe trottinette nơi công cộng đã gây ra rất nhiều tai nạn, không chỉ cho bản thân họ mà cho cả người đi bộ trên vỉa hè. Theo số liệu của Libération số ra ngày 01/04, trong năm 2021, trotinette điện gây ra 24 vụ chết người, số vụ tại nạn trong 6 tháng đầu năm 2022 tăng 51% so với cùng kỳ năm 2021. Hồi tháng 12/2022, dựa trên số liệu của các bệnh viện, Viện Hàn Lâm Y Khoa Pháp công bố một báo cáo đáng lo ngại, cảnh báo về mức độ nghiêm trọng của các chấn thương liên quan đến trottinette điện, nhất là liên quan tới vùng đầu của nạn nhân : 9/10 người không đội mũ bảo hiểm khi tai nạn xảy ra. Sự vô ý thức của người sử dụng cũng khiến thành phố trông vướng víu, rối mắt với những chiếc xe trượt hai bánh chạy bằng điện bị quẳng bừa bãi, ngổn ngang khắp nơi, cả dưới đường và trên hè phố, cho dù các công ty đã lắp đặt 2.500 bãi đậu xe, theo số liệu của Les Echos.Tốt hay xấu cho môi trường ?   Về mặt môi trường, trottinette điện vẫn được quảng bá là giải pháp có lợi, nhưng thực chất ra sao ? Ngày 31/03, nhằm giúp công chúng hiểu hơn về tác động của xe trượt hai bánh chạy bằng điện đối với môi trường, nhà báo Nicolas Quénard của NOWU giải thích trên đài France Info :« Quả thực, xe trượt chạy bằng điện gây ô nhiễm vì 2 lý do : thứ nhất là trong quá trình sản xuất khung nhôm và pin điện lithium mà việc khai thác và tái chế là một vấn đề thực sự cho môi trường, lý do thứ hai là ở việc quản lý hàng ngày, mỗi buổi tối người ta phải đi thu gom những chiếc xe đó, sạc điện, rồi đến sáng hôm sau lại phải đưa trottinette đến các bãi đậu xe.Nói tóm lại, hồi năm 2019, tính tất cả những hoạt động nói trên, thì cứ chạy 1 km thì mỗi chiếc xe trượt chạy bằng điện thải ra môi trường khoảng 110g CO2, nhưng từ 2 năm trở lại đây, chúng ta có thế hệ xe trượt chạy bằng điện mới, có tuổi thọ cao hơn, pin điện có thể tháo rời và nhìn chung thì việc quản lý cũng tốt hơn nên tác động tới môi trường củaxe trượt hai bánh chạy bằng điện cũng đã giảm một nửa. Vì vậy, lượng khí CO2 thải ra môi trường đã giảm từ 110g xuống còn 60g/xe/km. Nếu nhìn nhận là mọi việc đi lại, di chuyển đều gây ô nhiễm môi trường, thì chúng ta có thể nói rằng xe trotinette thuộc nhóm các phương tiện thô sơ nhưng có mức gây ô nhiễm cao. Xin nói rõ hơn một chút, đi xe trượt điện hai bánh gây ô nhiễm ít hơn 3-4 lần so với đi xe hơi, nhưng lại gây ô nhiễm nhiều hơn so với xe bus hoặc đi tàu RER. Còn nếu so sánh dịch vụ cho thuê xe trượt chạy điện với các phương thức di chuyển cá nhân dùng chung khác, thì biểu đồ của chúng tôi cho thấy dịch vụ xe trượt điện hai bánh gây ô nhiễm nhiều hơn so với dịch vụ cho thuê xe đạp, dù là xe đạp thường hay xe đạp điện, thậm chí xe máy chạy điện cũng ít gây ô nhiễm hơn.Nếu quý vị sử dụng dịch vụ thuê xe trượt chạy điện để thay cho việc đi xe hơi thì không vấn đề, nhưng nếu là để không phải đi bộ hoặc đạp xe trong Paris thì sẽ gây tác động về môi trường. Thế nhưng, xe trượt hai bánh chạy điện cũng có những tác động tích cực đối với môi trường, chẳng hạn như, chỉ tính riêng ở Paris, trotinette cũng giúp tránh bớt được 7.400 tấn CO2 ». Nhìn ra thế giớiTrở lại với dịch vụ cho thuê trottinette điện, thực ra, cho đến nay, quan điểm về dịch vụ cho thuê trotinette điện ở nhiều nước vẫn rất khác nhau. Ngay tại Pháp, nhiều thành phố khác đã cấm dịch vụ cho thuê trottinette điện, chẳng hạn Nice và Toulouse. Nhìn sang láng giềng Tây Ban Nha, chẳng hạn Barcelona cũng có biện pháp tương tự cách nay vài năm. Theo trang mạng của đài France Info ngày 31/03, ngay từ hè năm 2018, sau khi các doanh nghiệp cho thuê trottinette điện bày hàng ngàn xe khắp thành phố mà không có sự cho phép từ phía chính quyền, việc phóng xe trên hè phố cũng gây nhiều tai nạn, nhà chức trách ngay lập tức đã ra lệnh cấm dịch vụ. Công ty nào đề xuất dịch vụ cho thuê trottinette điện để khách tham gia lưu thông trên đường phố sẽ bị xử phạt. Còn tại Canada, cách nay 3 năm, chỉ sau 9 tháng thử nghiệm dịch vụ cho thuê xe trottinette chạy điện, chính quyền thành phố Montréal đã cấm hẳn việc trotinette điện, bất kể là trottinette cá nhân hay dịch vụ, tham gia giao thông. Từ Montréal, thông tín viên RFI Léopold Picot hôm 31/03 gửi về bài phóng sự : « Thật khó để tìm được một người dân Montréal vẫn còn nhớ là họ đã từng nhìn thấy những chiếc trottinette của các hãng cho thuê. Bà Luce thì còn nhớ, nhưng không thích chúng lắm. Bà chia sẻ : « Vâng, đúng là từng có đấy, nhưng chỉ trong thời gian ngắn thôi. Những con đường dành cho xe đạp cũng đã đông đúc lắm rồi. Tôi thì đi xe đạp, mà xe trượt hai bánh thì chả tốt gì cho những người đi xe đạp ».Phải duy trì trật tự, đó là điều đã thuyết phục thành phố ngừng việc cho thử nghiệm xe trượt chạy điện : bởi vì 80% số xe đỗ sai vị trí. Ông William nghĩ rằng vấn đề thực sự liên quan đến dịch vụ cho thuê xe truợt điện hai bánh : « Theo những gì tôi thấy, chính các công ty tư nhân đã quản lý kém dịch vụ cho thuê trottinette điện. Tôi không nghĩ chúng tôi cần dịch vụ đó. Vì thế, tôi mong người dân Paris bỏ phiếu phản đối xe trottinette ».Một số người không cưỡng lại được nên vẫn dùng trottinette của riêng họ mà không biết rằng làm thế là phạm luật, bởi luật Quebec không cho đi xe trottinette trên đường. Đối với Philippe Sabourin, người phát ngôn của thành phố, việc sử dụng trottinette chỉ được hạn chế trong nhà hoặc ở các khu vực có quy định cụ thể. Ông nói : « Thành phố Montreal không có ý định giới thiệu trở lại dịch vụ cho thuê xe trottinette điện. Nhưng vào mùa hè, những người đến công viên Jean Drapeau thì vẫn có thể thuê một chiếc xe trottinette điện và đi ở đó ».Như vậy có nghĩa đó là trò giải trí hơn là một phương tiện giao thông, kể cả khi phe đối lập ở Montreal vẫn muốn cho phép lại dịch vụ cho thuê trottinette điện, nhưng với những quy định kiểm soát tốt hơn ». Nhìn sang châu Á, thủ đô Tokyo của Nhật có các quy định rất chặt chẽ. Các trottinette điện bị xem là phương tiện giao thông cơ giới, chỉ được chạy ở làn đường dành cho xe hơi, nên phải tuân thủ các quy định như đối với xe hai bánh động cơ có dung tích dưới 50cm3 : người sử dụng phải có giấy phép lái xe hơi, mô tô hoặc ít nhất là giấy phép cơ bản dành cho xe hai bánh, phải đội mũ bảo hiểm, xe phải có gương chiếu hậu và có biển số đăng ký. Vận tốc trotinette điện bị Tokyo giới hạn ở mức 30km/h.  Cuộc bỏ phiếu ở Paris vừa qua vẫn còn gây nhiều tranh cãi về tính dân chủ, phương thức tổ chức, số người tham gia hạn chế … Chính quyền Paris vẫn bị chỉ trích là do thiếu biện pháp quản lý hiệu quả nên tìm đến biện pháp cấm cản. Những cái lợi, cái hại của trottinette điện vẫn còn gây chia rẽ giữa phe « trẻ » và phe « già ». Vẫn còn những ý kiến trái chiều giữa chính quyền và giới làm dịch vụ, giữa đô trưởng Paris Anne Hidalgo với chính phủ Pháp vốn ủng hộ giải pháp thắt chặt quy định thay vì cấm triệt để, thậm chí ngay trong giới đấu tranh bảo vệ môi trường, sinh thái, nhưng dẫu sao thì Paris cũng trở thành thủ đô đầu tiên tại Liên Hiệp Châu Âu thông báo cấm hoàn toàn dịch vụ cho thuê xe trượt hai bánh chạy bằng điện.

On commence avec la 11ème journée de mobilisation contre la réforme des retraites… mobilisation en baisse, le traffic dans le RER et le métro parisien est normal

Who knew the good old term “tying up” could have so many meanings? This episode digs into some different muscle myopathies (i.e. PSSM 1, PSSM 2, RER, and MFM) and provides tips for how we can tweak the diet and manage a horse for the best outcome. Resources: • (ER) Exertional Rhabdomyolysis: https://cvm.msu.edu/research/faculty-research/comparative-medical-genetics/valberg-laboratory/exertional-rhabdomyolysis • (RER) Recurrent Exertional Rhabdomyolysis: https://cvm.msu.edu/research/faculty-research/comparative-medical-genetics/valberg-laboratory/recurrent-exertional-rhabdomyolysis • (PSSM 1) Polysaccharide Storage Myopathy 1: https://cvm.msu.edu/research/faculty-research/comparative-medical-genetics/valberg-laboratory/type-1-polysaccharide-storage-myopathy • (PSSM 2) Polysaccharide Storage Myopathy 2: https://cvm.msu.edu/research/faculty-research/comparative-medical-genetics/valberg-laboratory/type-2-polysaccharide-storage-myopathy • (MFM) Myofibrillar Myopathy: https://cvm.msu.edu/research/faculty-research/comparative-medical-genetics/valberg-laboratory/myofibrillar-myopathy You can now follow @drjyme on Facebook and Instagram! Please tell your friends how #feedroomchemist has made you an #empoweredhorseowner! …. If you have a topic or question you would like addressed on a future episode please email info@bluebonnetfeeds.com Dr. Jyme Nichols is Director of Nutrition for Bluebonnet Feeds and Stride Animal Health. For more information on these brands or a free virtual nutrition consult from our team just visit bluebonnetfeeds.com/nutrition-consult --- Send in a voice message: https://podcasters.spotify.com/pod/show/feedroomchemist/message

The train system in France is known as the SNCF and is one of the most extensive and well-connected train networks in Europe. With high-speed trains such as the TGV and regional trains, the SNCF offers fast and convenient transportation throughout the country, connecting major cities and remote regions. Additionally, the SNCF operates an extensive network of suburban trains, known as the RER, in the Paris region, making it easy for residents and visitors to get around the city and its suburbs. Overall, the train system in France is an efficient and reliable mode of transportation for both short and long-distance travel. This episode is a a reference for anyone who wants to travel in France using the train. The French train system is not perfect, but once you learn how to use it, you'll find it relaxing and satisfying. able of Contents for this Episode [00:00:36] Today on the podcast [00:01:59] Podcast supporters [00:03:04] VoiceMap Tour of Paris Eiffel Tower [00:03:33] France Bootcamp [00:03:48] Next week on the podcast [00:04:15] Newbies' Guide to Taking the Train in France [00:05:08] Overview [00:05:26] Chronotrains [00:06:35] Traveling from a French city to another via Paris [00:07:30] Regional trains TER [00:08:35] The RER system in Paris [00:09:48] Rome2Rio [00:10:44] How and when to buy tickets [00:12:06] Apps useful to buy tickets [00:14:58] Sleeper trains [00:16:31] Eurail app [00:18:15] Deals if you book in advance [00:19:11] Buy tickets at the machine or use the SNCF-Connect app [00:20:10] Île-de-France region [00:21:57] Week's pass [00:22:55] Bonjour RATP app [00:24:17] Navigo Découverte card [00:26:49] Getting the right train to go to Giverny [00:28:33] How do you take the train? [00:36:09] Finding your seat [00:36:49] Where should you stand on the platform for quick stops? [00:38:14] Catching a train from a station that's not a terminal station [00:38:59] Entering or exiting the train at a continuing station [00:41:14] Don't count on good data on the train [00:42:03] Grandes lignes vs Metro lines, etc. [00:43:12] Food at the train stations [00:45:03] Large train stations have lockers and Nanny Bags [00:45:42] Discount cards for French trains [00:47:50] Use the app [00:49:06] Advantage card and why the Trainline app is useful [00:50:29] Date format [00:51:24] Travel light and train travel with kids [00:52:53] Copyright

Valérie Pécresse répond aux critiques qu'ils l'accusent d'être responsable de l'annulation du concert de Beyoncé en région parisienne pour cause de travaux sur la ligne du RER du Stade De France

Please join Guest Host Maryjane Farr, authors Sarah Franklin and Stavros G. Drakos, as well as Associate Editor Hesham Sadek as they discuss the article "Distinct Transcriptomic and Proteomic Profile Specifies Heart Failure Patients With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your cohosts. I'm Dr. Carolyn Lam, associate editor from the National Heart Center in Duke National University of Singapore. Dr. Peder Myhre: And I'm Dr. Peder Myhre, social media editor from Akershus University Hospital and University of Oslo. Dr. Carolyn Lam: Peder, today's featured paper is very, very important in the heart failure world. It is such a deep dive into the transcriptomic and proteomic profile that specifies heart failure and the potential of myocardial recovery with mechanical unloading and circulatory support. Dr. Peder Myhre: Can't wait for that feature discussion today, Carolyn. Dr. Carolyn Lam: But you have to wait because I insist on telling you about yet another really important paper, of course in my favorite subject, heart failure with preserved ejection fraction or HFpEF. Now you know that exercise intolerance is a defining characteristic of HFpEF and a marked rise in pulmonary capillary wedge pressure during exertion is pethepneumonic for HFpEF and it's thought to be a key cause of the exercise intolerance. Now if that is true, acutely lowering the wedge pressure should improve exercise capacity, right? Well, don't assume this because to test this hypothesis, authors led by corresponding author Dr. Ben Levine from UT Southwestern evaluated peak exercise capacity with and without nitroglycerin, which was used to acutely lower pulmonary capillary wedge pressure during exercise in patients with HFpEF. Dr. Peder Myhre: Oh, that's so cool. What an amazing research question and Carolyn, you're the best to summarize this. Please tell us what did they find? Dr. Carolyn Lam: Well, they studied 30 patients with HFpEF and get this. They underwent two bouts of upright seated cycle exercise dosed with sublingual nitroglycerin or a placebo every 15 minutes in a single blind randomized crossover design. So really well done. Wedge pressure, VO2 and cardiac output were assessed at rest with 20 watts exercise and at peak exercise during both the placebo and nitroglycerin conditions and the principle finding of the study (singing) acutely lowering pulmonary capillary wedge pressure during upright exercise with nitroglycerin in HFpEF did not improve peak exercise performance. So peak VO2 was practically identical with a 1% difference despite a 17% drop in peak wedge pressure. Peak cardiac output and peak peripheral oxygen extraction were unchanged, again, despite the drop in peak wedge pressure suggesting that oxygen delivery and utilization were unaffected. Exercise performance variables including peak wattage, peak ventilation and peak RER were unchanged, suggesting that again, reductions in peak wedge were insufficient to improve exercise tolerance. All these results suggest acute reductions in wedge pressure are insufficient to improve exercise capacity and provide convincing evidence that a high wedge during exercise by itself is an epiphenomenon perhaps rather than a primary limiting factor for exercise performance in patients with HFpEF. Now of course this is incredibly interesting contrary to hypothesis and so please read the paper. The discussion is very rich. Dr. Peder Myhre: Oh wow, Carolyn. That is such a great paper. I can't wait to pick it up and read it from start to finish and now Carolyn, we're going to look into research within cardiovascular disease from COVID-19 and we have learned so much and so quickly about COVID-19 and its effects on the heart and we have really come a long way from the first case reports reported in the beginning of the pandemic and this paper, which comes to us from corresponding author Professor JP Greenwood, really adds important knowledge to this field. The COVID heart study was a prospective longitudinal multi-center observational cohort study of patients hospitalized with COVID-19 and at elevated serum troponin levels across 25 hospitals in the UK and these investigators aim to characterize myocardial injury, its association and sequela in convalescent patients following hospitalization with COVID-19 utilizing appropriately matched contemporary controls. Dr. Carolyn Lam: Ooh, important stuff. So what did they find? Dr. Peder Myhre: So these authors included in total 519 patients comprising 342 patients with COVID-19 and an elevated troponin, 64 patients with COVID-19 and a normal troponin and 113 age and comorbidity matched controls without COVID-19 and the frequency of any heart abnormality defined as left or right ventricular impairment, scar or pericardial disease was two full greater in patients with COVID positive and troponin positive, so 61% compared to the control groups and that is 36% for COVID positive and troponin negative and 31% for COVID negative and comorbidity positive and the myocardial injury pattern was different for these patients with COVID and an elevated troponin more likely than controls to have infarction and micro infarction. But there was no difference in non-ischemic scar and using the late MRI criteria, the prevalence of probable recent myocarditis was almost 7% for those with COVID and elevated troponin compared to only 2% for the controls without COVID-19 and myocardial scar is but not prior COVID-19 infection or troponin was an independent predictor of MACE. So Carolyn, these authors discussed their findings in light of previously reported studies and these authors identified a lower prevalence of probable recent myocarditis than previously described and a higher proportion of myocardial infarction and this newly described pattern of micro infarction following COVID-19 and Carolyn, there is a brilliant editorial really summarizing this by Dr. Stuber and Baggish entitled "Acute Myocardial Injury in the COVID Heart Study Emphasizing Scars While Reassuring Scarce." I really recommend everyone to pick this up and read the editorial as well. Dr. Carolyn Lam: Very clever title. Thank you. For the last original paper in today's issue, it focuses on the crosstalk between sterile metabolism and inflammatory pathways, which have been demonstrated to significantly impact the development of atherosclerosis. Authors today are featuring and focusing on 25 hydroxy cholesterol, which is produced as an oxidation product of cholesterol and belongs to a family of bioactive cholesterol derivatives produced by cells in response to fluctuating cholesterol levels and immune activation. So these authors with co-corresponding authors, Dr. Suárez and Fernández-Hernando from Yale University School of Medicine, they showed beautifully that first, 25 hydroxy cholesterol accumulates in human coronary atherosclerosis. Next, that 25 hydroxy cholesterol produced by macrophages accelerated atherosclerosis progression and promoted plaque instability by promoting the inflammatory response in macrophages and also via paracrine actions on smooth muscle cell migratory responses. Dr. Peder Myhre: Wow, that is so interesting, Carolyn. What are the therapeutic implications of these findings? Dr. Carolyn Lam: Yes, I'm glad you asked because it was summarizing a lot of work in those findings with the very important implications that inhibition of 25 hydroxy cholesterol production might therefore delay atherosclerosis progression and promote plaque stability. So this study actually opens a door to explore the role of 25 hydroxy cholesterol as a target to control inflammation and plaque stability in human atherosclerosis. Dr. Peder Myhre: Oh, that is so important. Thank you so much and there is more in this issue as well, Carolyn. We have another issue of Circulation Global Rounds and this time we're going to France in a paper written by Dr. Danchin and Bouleti. We also have an exchange of letters by Dr. Yang and Dr. Schultze regarding the article, "Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation" and an ECG Challenge by Drs. Manickavasagam, Dar and Jacob entitled "Syncope After Transcatheter Aortic Valve Implantation: Pace or Not." Dr. Carolyn Lam: Interesting. There's a Frontiers paper also by Dr. Dimopoulos on “Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus,” a Research Letter by Dr. Kimenai on the impact of patient selection on performance of an early rule out pathway for myocardial infarction from research to the real world. Nice. Well let's carry on to that feature discussion on heart failure, transcriptomics and proteomic, shall we? Dr. Peder Myhre: Can't wait. Dr. Maryjane Farr: Welcome everybody to Circulation on the Run. We are so pleased to be talking with Dr. Stavros Drakos and Dr. Sarah Franklin from the University of Utah. My name is Maryjane Farr and I am the heart failure section chief at UT Southwestern and Digital Strategies editor for circulation. Myself and Hesham Sadek will be talking with them about their new paper and circulation called "Distinct Transcriptomic and Proteomic Profile Specifies Heart Failure Patients with Potential of Myocardial Recovery Upon Mechanical Unloading and Circulatory Support." Just briefly, Dr. Stavros Drakos is the director of cardiovascular research for the division of cardiology at Utah and co-director of the Heart Failure Mechanical Circulatory Support and Heart Transplant Program. Dr. Sarah Franklin is associate professor of medicine at the University of Utah whose lab has a specific expertise in the applications of proteomics to heart disease. Welcome, Stavros and Sarah. Dr. Sarah Franklin: Thank you. Dr. Stavros Drakos: Thank you. Thank you for having us. Dr. Maryjane Farr: This paper is exciting for clinicians. It's exciting for translational scientists. Hesham, why don't you start digging into this paper and tell us one or then the other of you tell us what this paper is about, what's the background and let's get into the science. Let's go there and then we'll pull back and look at some of the big picture stuff. Hesham. Hesham Sadek: Well, thank you. So I've been fascinated by the field of cardiac recovery for some time now and obviously Stavros is as an expert and one of the leaders of that field and what struck me about this is that we are starting to see some distinct molecular signature of patients that can experience recovery as opposed to patients undergoing the same procedures with the same profile that do not manifest evidence of myocardial recovery and specifically, the study was conducted very rigorously and the signature was very clear in that they saw primarily interest for someone like me who's interested in cardiac regeneration, a signature of cell cycle in the patients that experience recovery as well as ECM signature which could suggest reverse remodeling and also there's some evidence that ECM might impact cardiomyocyte and myocardial regeneration. So my interest in this for selfish reasons is primarily that this supports the hypothesis that perhaps there is a molecular signature of regeneration that occurs in patients that experience myocardial recovery with LVAD. Dr. Maryjane Farr: So Stavros, let's start with you. Give us the reason why to do this study. You mentioned some of the background. It'd be great to sort of talk for a moment about re-stage heart failure and then how it brought you to this study. Dr. Stavros Drakos: Thank you, Jane. So again, thank you for the opportunity to talk about the findings and the implications of this study. I like the way you are asking us to look a little bit at what led to this study and as you mentioned, the re-stage is a multi-center study that was performed in six US sites which showed in a reproducible fashion now given that we had single center studies from all over the world suggesting that, advanced heart failure is not an irreversible process that has to lead to end stage, an irreversible disease and what a re-stage demonstrated was that there is a subset of patients which if you select them based on clinical characteristics that we derived from other studies that were performed previously, you can achieve reverse remodeling, essentially a bad heart looking much better by every clinical, functional, structural characteristic in up to 50% of the selected patients. That's what re-stage showed. So having this finding now in a multicenter study, what made this study very timely was to be able to understand what drives this remarkable response. What are some of the mechanisms, as Hesham said, that we can if uncover take advantage of and expand this paradigm and enhance it and achieve reverse remodeling and recovery of even more patients and even go earlier in the disease process. So that's kind of how I would link the clinical findings that preceded this study with the motivation to perform the study and the implications of these findings for the ongoing translational and basic science research. Hesham Sadek: I'd like to ask a question here. So Stavros, do you think it's too early to sort of redefine the term reverse remodeling in this context to include perhaps some evidence of regeneration? Is there evidence of regeneration in this field or that's too premature to say? Dr. Stavros Drakos: I think the data are directing us towards the direction you just mentioned. I think that we can begin talking about it and planting the seed. We do have other evidence from work that you and others have performed indicating that this indeed is one of the mechanisms that drives this phenomenon and I think that the findings, especially in the cell cycle that we identified add to and contribute even more to that body of work that you and others have done. At this point, I will turn it to Sarah who can talk a little bit more about the findings related to the cell cycle that we identified in our study and I think that these may complete the answer to you, Hesham. Dr. Sarah Franklin: Yeah, I would love to comment. I think it's a really interesting phenomenon and really in these patient samples we were trying to understand molecularly what the difference is between individuals that respond positively to therapy and individuals that receive the same exact therapy and do not respond positively. So these are termed responders and non-responders and in our analysis we combined two platforms where we could molecularly interrogate what's different in these two tissues and try to see what is differentiating these populations. So what's consistent and reproducible different in responders and non-responders on a molecular level and in both the transcriptomic data and the phospho proteomic data, we saw clear patterns with cell cycle regulation and extracellular matrix or focal adhesion molecules and the interesting thing about cell cycle is cardiomyocytes have typically been thought to exit the cell cycle not long after birth and we see some interesting phenomenon either in humans or mice where we can have nuclei that have either multiple sets of chromosomes or multiple nuclei and there's some differences that have been observed in the nucleus with regards to disease, so hypertrophy, heart failure. So the molecules that we've identified, we saw a large difference in proteins involved in cell cycle regulation. Now the interesting thing is not all of those molecules are increasing or decreasing. We see a combination of molecules that are increasing or decreasing. But I think the other thing that's interesting is that these molecules, even though we are seeing changes in expression or changes in phosphorylation, exactly how that contributes to either cell cycle or cell cycle reentry or just nuclear function and transcription of proteins or genes or DNA regions is still what we need to continue to study. So exactly how these changes in proteins or transcripts related to the cell cycle, how they are exactly contributing to the physiological improvements that we're seeing is something that still needs to be investigated but is really important that that is a highlight of this study and as Stavros mentioned of previous work. Dr. Maryjane Farr: Stavros, tell us the design of the study. Dr. Stavros Drakos: Okay. So this study was performed in 93 patients that were prospectively enrolled in the Utah transplant affiliated hospitals here in Salt Lake City between the University of Utah, Intermountain Medical Center and the VA and these people came from all over the mountain west, the surrounding states of Utah and through our VA, through the state, from all over the west and south, from Alaska and Hawaii to Texas and we think it's a very representative population of our country's patient population and then we followed prospectively these people with serial echocardiograms so we can tell who will respond as Sarah said before, which essentially means which hearts are going to get better by echocardiographic criteria functionally and structurally, the dimensions of the heart shrinking and the ejection fraction improving to more than 40% and the dimension shrinking to normal range and then we compare these people, the subset of patients that have responded to the majority of patients actually that they have not responded. As we know these are advanced end stage patients and there is only a subset of those that they will favor respondents. As we said earlier, these subset can increase if you go selectively and pick these patients based on baseline characteristics. So then we analyze the tissue we got from these people when the LVAD went in, which is the core of the apex of the heart and compare that to the tissue we receive when the patients got transplanted and we got the whole heart. So in the meantime, as we just discussed, we phenotyped these people so we knew who were responders and non-responders and then we went back in the lab and tried to marry two basic processes, analyzing the transcriptome and the proteome and by doing that we were able to see some overlapping changes between the transcriptome and the proteome and we felt that by doing this overlapping analysis, we will increase the likelihood that what we are seeing, exponential mechanistic drivers will be the real mechanism and not just associations that you can frequently find when you do studies in humans and that's kind of a rough, brief summary of the design. Sarah, would you add something to that? Dr. Sarah Franklin: No, I think that's a great overview of it. I think what excites me about it is that this was first clinically observed that these patients were recovering and so I think the exciting part is the hypothesis was that there was some molecular underpinnings that could molecularly define these patients that were responding or not responding and so with that hypothesis we then carried out these analyses hoping that we would see a difference and we're very excited. It's very successful in that we found very clear, molecular differences that are reproducible between these patient populations. Dr. Maryjane Farr: So obviously there's lots of implications. Let me start with one very simple clinical one and that is, so based on some of the differences in the signatures and pathways that you saw for the next patient who needs LVAD therapy and you're trying to predict in some way whether they may be a responder or a non-responder, could you look at a biopsy sample and try to make some sort of prediction based on some of your findings so that they can choose a VAD over a transplant? That's a very clinical question and then I guess the second question is would it have to be a left ventricular myocardial sample? So are the differences? What do you think about that question? Or it's just too much too, far beyond? This is obviously a mechanistic study. But I'm just asking. Dr. Stavros Drakos: No, that's a great question and I'll start and Sarah can add later. So obviously it will be great if we can have a practical way to predict before the intervention who are the people that they will respond and that's one of the motivations for this study. It was not just to find the mechanism so we can make this phenomenon better and enhance it and find the mechanism, create new therapies. It was also the practical approach that you suggested, Jane, and I think that yes, this adds to the clinical predictors that we have already identified from other studies and yes, we could theoretically take the tissue and do this analysis. Is this the most practical thing we can say to the patient to biopsy the heart, right? It would've been better to be able to identify a biomarker in the plaque and we've done that. We started in other studies, identifying what's going on in the tissue and then going targeted in the blood and that's how we identified two cytokines and a two cytokines model, interferon gamma and TNF alpha being predictive as circulating biome. In this study we identify changes that can also inform future studies of biomarkers in the blood. But if we had a way to easily get the tissue and analyze the genes, yes, we could have done that as a predictor as well. The practical issue is that asking a patient for a biopsy just to predict the response to therapy may be something that most patients and most clinicians will consider way too advanced and complicated, right?that's why more work should and could be done to identify circulating biomarkers or other modalities that can help us interrogate what's going on in the heart related with these findings. But not that we cannot also do what you said. It's just more complicated. I don't know if Sarah would like to add to this. Dr. Sarah Franklin: I'd love to. I think that's a great overview. I think the only thing that I would add is that there are a number of conditions whether in the heart or otherwise in the body that you can use a single biomarker and it can be very predictive of conditions. Heart failure is so complex that often individual biomarkers are not sufficient enough to cover an entire population and all the nuances that can go into heart failure symptoms or syndromes and I think the exciting part about this study is it is one of the largest cohorts of patients that have been examined in this manner, which is exciting, but also that we have a multi-factor panel that is made up of multiple biomarkers that with the number of individuals that we examined is completely predictive of all of these patients. So these biomarkers are consistent and reproducible across all of these patients between responders and non-responders regardless of some of the nuances in the heart failure that they have and so it's very exciting because it's possible that a multifactorial panel could be much more applicable and last the test of time more so than an individual biomarker. I think the one other thing that is exciting like Stavros mentioned is that we did initially identify these in the left ventricle and it will be really exciting to see how far these biomarkers can be used if they can be used in potentially other aspects of the heart or blood, which obviously is less invasive and so that's not something that we've applied this panel to yet, but I think is a really wonderful extension of now saying, can we also identify some of these biomarkers in the blood which would be less invasive even if it's a fraction of them. That would still be wonderful. Dr. Maryjane Farr: I have so many clinical questions. But Hesham, what questions do you have? Hesham Sadek: Yeah, so the elephant in the room here obviously is that the variable is that these patients have an unloaded heart and there is evidence that unloading can reverse some of the changes that occur after birth with increasing ventricular load and initiate cascade of molecular events that may allow myocytes to proliferate. So this begs the question, is there a difference in how these ventricles of patients that recover versus those that do not recover see load? Are we able to measure load appropriately and is there a difference in load between these patients and if so, can this be improved or detection or measuring unloading or the degree of unloading clinically, can this be improved? Dr. Stavros Drakos: No, that's a great question and it provides the opportunity to talk about some of the things we can do on the clinical arena to further enhance this phenomenon. Yes, there are ways that we can use to tailor the mechanical unloading that we can provide in order to enhance this phenomenon. One way, and that's a study that we are proposing, is to use sensors, pressure sensors that can guide the way you function the machines, the devices, right? The way you remove part of the load and these sensors, some of them are clinically approved like cardioments and then without doing invasive procedures you can follow chronically how these patients are being unloaded and how the heart is responding to this unloading. We know that a lot of LVAD patients, despite doing clinically well, we know this from snapshot evaluations in right-heart cath studies, they are not optimally unloaded. They are feeling pressures left and right are not always optimized and so by doing this kind of prospective assessment of the mechanical unloading, you can tailor what you offer and the hypothesis generated is that by doing that you may be able to recover even more people. You can do this as we said, with approved sensors like cardioments or with other sensors that they are under investigation. You can also do more invasive stuff like PV loops. Of course these will require cathing these patients, which is a little bit more complicated. But it will provide more accurate assessment and it will also interrogate how the heart is improving and provide to you in-depth investigation and in-depth insights on also how the recovery process and the reverse remodeling process is being, I would say, digested by the heart and translated to functional response instead of just looking at it with an echocardiogram or the findings of a right-heart cath and these are studies that others have performed and have published and we know that they can give you a real good look into the systolic and diastolic function of the heart and how this is changing and improving down the road. So yes, that's the short answer. We can do that and we can tailor the unloading and potentially that's the hypothesis, maximize the effect that we saw here. Hesham Sadek: So this begs the question, maybe two questions here. One, is there evidence that patients who recover not from this study only but from other studies, is there evidence that patients who recover are more unloaded than patients that do not recover and the second question is: is it time to standardize assessment of mechanical load in patients with LVAD, especially those that will undergo or would be considered for recovery? Dr. Stavros Drakos: Yes. So that's a great opportunity to share with our audience what we know and what we don't know in this field in relation to your question about whether we know what is the optimum degree of unloading and the answer I think is that we need to know and understand more. What do I mean by that? There's this idea that the heart as every other organ after being unloaded and not working for some time may it lazy, may get atrophic and may need some rehab like the skeletal muscle when we put it in the cast and get atrophic and we need to rehab it when we remove the cast. So you can imagine that the LVAD and the unloading that provides, which in many cases may take over a significant part of the function of the heart may need gradual reloading as a second phase after the first phase of unloading and that's something that we've done. We have an ongoing study on this and also others have published that it may be beneficial. Of course, it needs to be validated and investigated further and to discuss about the degree of unloading in the first phase and what is the optimum degree of unloading, I would say even there, there is room for us to understand better what's going on and I think that we can investigate with ongoing studies right now whether full unloading versus partial unloading and measure the pressures using these sensors can translate to better changes functionally and structurally. I think that's something that is very doable and it would be very beneficial. What was the second part of your question, Hesham? Hesham Sadek: I was asking whether it's time to start standardizing some measure of unloading if these patients are planned for recovery? Dr. Stavros Drakos: Yes, and that's what we are doing. In all of these people, we report from the get-go what is their recovery score based on the intermixed ICARS derived score and when we have patients that they have high likelihood of recovery, we monitor them very closely and clinically what we do is just looking at the echo and whenever we do a right heart cath for clinical reasons. But in a prospective research study we could do more than just looking at the echo and occasional right heart cath and using the sensors we just discussed previously, you can tailor the unloading and begin prospectively unloading them in a more I would say well monitored wave. Yes. Hesham Sadek: So this is unloading or device specific parameters. Now are there patient specific parameters with regards to type of heart failure? So we talked initially about whether there's an element of regeneration specifically when it comes to cell cycle. But many patients with non-ischemic cardiomyopathy for example, don't have large scars and don't have lot of myocytes as the underlying cause of cardiomyopathy. Would you foresee that there is different mechanisms, for example, in these patients that don't have myocyte loss, that perhaps maybe it's not cardio myocyte proliferation and not regeneration? Dr. Stavros Drakos: Yes. So I think that the differential responses we get based on the heart failure theology warrant further investigation. Sarah and I have discussed that and actually we are following on our findings with larger number of patients so we can tease out these and I'll let Sarah talk a little bit more about it in a minute. But to answer the clinical part of this question, we don't know yet whether different parts of heart failure should be prescribed different modes of unloading. But the way you described it of course invites the hypothesis that of course different substrates, different injuries of the heart, as you said, it's a completely different failing heart if you have a big scar there versus a patient who has a mode of heart failure, another type of injury and would this be treated better and more effectively in terms of reverse remodeling by applying a different mode of unloading? That's things that we need to investigate further. But Sarah, would you like to comment on the potential on the effect of the different heart failure theologies on some of the findings we saw? Dr. Sarah Franklin: Yeah, definitely. So I think it's a really interesting question and in this analysis we included ischemic and non-ischemic samples in the patient populations and really we're just stratifying them based on responders and non-responders. When we start layering additional levels onto that, then we're effectively kind of reducing the potential numbers. So if we have 25 responders and we start breaking that down into ischemic and non-ischemic to see if there's another layer of biomarkers there, we actually did that we did not include it in this study. It's something that we're working on to add that. But we do reduce the number overall of patients in those two populations. So it would be fine to share that we were seeing stratification between ischemic and non-ischemic. But we did not feel like the numbers might be high enough within the responder and non-responder categories that warrant including that in this manuscript. So it's very intriguing that just responders and non-responders alone stratify as well as they do. They separate based on these biomarkers and it looks like it will also be possible in the future for us to even separate these samples further based on similar or additional biomarkers based on more specific factors in the etiology. So I think that will be another really exciting next step for future research. Hesham Sadek: My final question would be maybe a little bit broader than LVAD population, but definitely informed by this study. The term non-ischemic cardiomyopathy, do you think it's too broad and too vague for us to use in this setting because this encompasses many different types of cardiomyopathy that really are not nuanced enough by this definition. Dr. Stavros Drakos: Well, Jane was smiling while you were asking this question because we all as heart failure clinicians need to accept that it was not a good idea to name all of these different diseases non-ischemic cardiomyopathy when we did it or when this happened many moons ago. As you said, Hesham, and I couldn't agree more, these are completely different diseases. We need to understand them better and I think that the way we treat nowadays, chronic heart failure, many years down the road when people will look back, they will consider it a little bit, I would say, surprising that we were treating all of these the same way. We need more studies like the one we just did, that they will have enough numbers and that's when the issue becomes that you need enough numbers to be able to tell the differences between all of these non-ischemic cardiomyopathy types, theologies and if you go upstream, motivated and inspired by findings like this, we hope that we will be able to identify how to go and do a root cause analysis and treat these diseases, not down, down, downstream the same way, but going upstream, finding what really went wrong and treating them earlier in the molecular or other pathophysiological mechanism pathway that led to the heart failure and so yes, it was a bad idea to do that. But of course sometimes we do things because we don't understand it better, right? As one of our keynote speakers here in the recovery symposium said a few years ago, Jay Khan, the founder of Heart Failure Strata of America, some things look complicated until you understand them. Then when you understand them, they look simple. So here we don't really understand non-ischemic cardiomyopathy and how all these theologies lead there and I think studies like these can help us really inform the field better. But we will need, as Sarah said, more numbers. Dr. Maryjane Farr: So that was a great conversation. I wanted to just raise one last thing and that is what's so interesting about this cohort relative to re-stage heart failure is these were older patients and for re-stage heart failure, I think the average age was 35. So you would imagine there might have been one etiology for cardiomyopathy, uncontrolled hypertension or peripartum. But for cohorts in their fifties, there's probably an accumulation of different insults over many years time and so I thought that was particularly interesting from the point of view of that you were probably dealing with, again, a mixed bag of pressure overload, volume overload, maybe a genetic underpinning, whatever the life trajectory of some of these patients were and then lastly, the decision to try to go to recovery rather than to transplant, which would be the real world experience of why this wet pathway than the other. These are people truly in their fifties where they may have one or two surgeries in their lifetime left and so it's the relevant population that you're studying and so I'll leave it at that. That's a comment rather than a question, I think. But I think for heart failure clinicians, this is why the bench to bedside piece is so relevant to understanding this because it actually does change clinical practice, even if the mechanistic pathways may take still many more years to truly understand. It helps understand what's possible from an accrued clinical decision-making level. Dr. Sarah Franklin: Jane, if I might just comment on that, I actually think that's one of the most exciting parts about this dataset is that, as you mentioned, these patients have complex diseases. They are older. But yet we are still able to see consistent and reproducible differences between the patient populations that respond and don't respond and to me that suggests that at the end of the day there are consistent differences or reproducible or consistent molecular changes in cardiac tissue and in response to stress and I think that that gives us hope that we could potentially not only predict who would respond or not respond, but that as we get better at understanding the differences, that there could be potential therapeutic targets or therapies that would still be beneficial regardless of the complexity of the heart failure. Dr. Maryjane Farr: Okay. So Sarah, Stavros, thank you so much for spending time with Hesham and myself and look forward to EUCORS--I'm allowed to say that. Dr. Stavros Drakos: Of course. Dr. Maryjane Farr: Thanks so much. Bye. Dr. Greg Hundley: This program is copyright of the American Heart Association 2023. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

Sākot ar hercoga Jēkaba laika manufaktūrā, līdz pat 20. gadsimta nogalei Latvijas teritorijā būvētās, darbinātas un arī gājušas zudībā daudzas fabrikas un rūpnīcās. Daļa no tām ar skaļāku vārdu izskanējušas pasaulē, citas darbojušās tikai vietējam patēriņam, bet visas devušas savu artavu tehnoloģiju un zinātnes attīstībā Latvijas Nacionālajā bibliotēkā(LNB) jauna ekspozīcija par industriālo mantojumu. Rūpniecības vēsture Latvijas teritorijā aizsākās 17.gadsimtā, bet 19.gadsimtā Rīga jau bija nozīmīgs Austrumeiropas un visas cariskās Krievijas industriālais centrs. Digitālajā kolekcijā apkopota informācija par vairāk nekā 100 Latvijas bijušām un esošām ražotnēm. Kāds ir mūsu industriālais mantojums, vērtē LNB Digitālās bibliotēkas vadītājs Artūrs Žogla un LNB Digitālo pakalpojumu bibliotekāre Eva Ausēja. Ieskata rūpnīcas „Provodņik” vēsturē Gumijas ražojumu rūpnīca „Provodņik” līdz Pirmajam pasaules karam bija viena no lielākajām ražotnē Rīgā, te ražoja ķirurģijai domātu gumiju, linoleju, šļūtenes, rotaļlietas, bet visvairāk - galošas un autoriepas. Atceramies pirms 135 gadiem dibināto uzņēmumu. Krievu – franču sabiedrības  gumijas ražotne „Provodņik” tika dibināta 1888. gadā un bija lielākais rūpniecības uzņēmums tolaik Krievijas impērijā. Daudz dažādu gumijas izstrādājumu tika ražots šajā rūpnīcā, kura savas preces 95 % apmērā eksportēja uz ārvalstīm. Rūpnīca ar vērienu darbojās līdz Pirmajam pasaules karam, kad, evakuējot uzņēmuma iekārtas uz Krieviju, izveda aptuveni septiņus tūkstošus vagonu ar  „Provodņik” materiāliem.  Starpkaru laikā te darbojās vairāki uzņēmumi, un 1946. gadā te atvēra Rīgas elektromašīnbūves rūpnīcu (RER), kura darbojas līdz 2014. gadam. Tagad rūpnīcas ēkā mitinās īrnieki, te notiek dažādi mākslas un kultūras pasākumi, telpas plašumos ir  iekārtots pat skeitparks.  Mārtiņš Zvīdriņš, vēstures entuziasts un dažādu piedzīvojumu pasākumu rīkotājs, kurš jau pusgadu pa milzīgās rūpnīcas telpām vada ekskursijas, saka, ka ekskursantiem te patīk noķert piedzīvojumu sajūtu, paklimst pa namu, bet pievienoto vērtību te sniedz .Mārtiņa stāstījums par vēsturi. Starp citu vienas bijušās rūpnīcas ēkas garums bijis 266 metri. Salīdzinājumam – superlaineris „Titāniks” bija 269 metrus garš. Tātad, ja gribat apjaust „Titānika” parametrus, dodieties uz Sarkandaugavu, uz bijušās rūpnīcas „Provodņik” teritoriju. Savukārt Rīgas Jūgendstila centrā nule ir atvērta neliela izstāde, kurā eksponētas reklāmas kartītes no pagājušā gadsimta sākuma, grāmata par šo rūpniecības uzņēmumu un  suvenīrs – neliels  metāla zābaciņš, kurā iegravēti nozīmīgi skaitļi. Par to stāsta muzeja “Rīgas Jūgendstila centrs” projektu vadītājs Dzintars Gilba.

« Officiellement, seuls quelques dizaines de morts ont été recensés, mais, pointe Libération, le pays est débordé par une vague de décès sans précédent depuis le début de la pandémie. En quelques semaines, le nombre de cas est passé Chine de 3 000 à 4 000 par jour à plusieurs dizaines de millions. Le gouvernement ne publie plus le décompte officiel des malades – comme il le faisait depuis trois ans – mais la province du Zhejiang par exemple (aussi peuplée que la France) avance le chiffre d'un million de nouvelles contaminations quotidiennes et anticipe un pic atteint autour du Nouvel an avec deux millions de malades par jour. Des données compilées par plusieurs agences de presse étrangères évoquent 18 à 20% de la population chinoise déjà contaminée. » Virage à 180 degrés… Commentaire de Libération : « la situation est ubuesque, car après avoir vu les autorités verrouiller d'une main de fer le pays, le slogan qui aujourd'hui sert de ligne politique est que "chacun est responsable de sa santé". Qu'importe si le régime s'est fourvoyé dès le départ avec sa stratégie zéro Covid, qu'importe que des milliards aient été dépensés pour la mettre en œuvre pour rien, qu'importe que le taux de vaccination dans le pays y soit trop bas, qu'importe, en gros, que les autorités se soient trompées sur toute la ligne… Rien ne dit que cette vague XXL, qui pourrait encore grossir avec les transhumances prévues à l'occasion du Nouvel An, fragilise le pouvoir. Le vide démocratique est trop béant. C'est le tragique de l'histoire, conclut Libération : les Chinois n'ont pour l'instant retrouvé qu'une liberté, celle de pleurer leurs proches. » De nouveaux variants ? Des pénuries de médicaments ? « Chine : faut-il s'inquiéter de la flambée du Covid ? », s'interroge Ouest-France. Eh bien oui, répond le journal. Tout d'abord parce qu'on peut craindre l'émergence de nouveaux variants du virus. Et ensuite parce qu'il y a un risque de pénurie de médicaments… En effet, précise Ouest-France, « 80% des principes actifs, la matière première des médicaments, sont fabriqués en Chine et en Inde ». Et le paracétamol, médicament contre la fièvre, commence à manquer, en Chine et dans le reste du monde. ► À lire aussi : La Chine partagée entre ouverture et recrudescence de l'épidémie de Covid-19 Alors, des pénuries de médicaments, des nouveaux variants, des nouvelles vagues de Covid dans le monde ? C'est l'inconnue : « Soumises à la triple pression causée par l'explosion de l'épidémie, l'effondrement de l'économie et les protestations de la population, constate Le Monde, les autorités chinoises ont abandonné leur politique du jour au lendemain. La réouverture de la Chine ressemble à celle de la boîte de Pandore. » En France, les transports en crise À la Une du Figaro, un coup de gueule contre la situation catastrophique des transports par le rail à Paris et dans les régions. « Trains en retard ou supprimés, grèves, vétusté des voies, travaux… C'est la grande déconnexion entre les métropoles et les petites villes, entre les régions et la capitale, qui est à l'œuvre, dénonce Le Figaro. Intercités, TER, RER… les transports sont désormais plus imprévisibles que le temps !, fulmine encore le journal. La "France périphérique" ne compte plus les heures passées sur le quai. […] La liberté de ces Français dépossédés d'eux-mêmes se réduit en même temps que le maillage des régions se délite sous le coup de la désindustrialisation et des injonctions anti-voiture – sans compter aujourd'hui la hausse de l'énergie. Il est frappant, conclut Le Figaro, de voir combien l'affaissement des institutions autrefois garantes de ce bien commun qu'est l'aménagement du territoire fragilise aujourd'hui la puissance publique. » Un hiver trop doux… Enfin, décidément, il n'y a plus de saisons. Après des températures glaciales, mi-décembre, la France connait un redoux inédit. « Chaud devant ! », s'exclame L'Est Éclair en première page qui annonce qu'un record pourrait être battu ce week-end dans le département de l'Aube avec près de 17 degrés. « Dans les Pyrénées, on skie sur des cailloux », constate pour sa part Le Parisien. Certaines stations ont dû fermer de même que dans les Alpes. « Pourtant, la saison s'annonçait bien : le froid était glacial à la mi-décembre, la neige tombait en abondance. Mais les fortes pluies, dues aux températures trop douces, ont balayé le manteau neigeux. » Cette douceur hivernale s'observe déjà depuis quelques années, et ça ne devrait pas s'arranger. ► À lire aussi : En France, des associations veulent que l'environnement soit mieux traité dans les médias

Dr Glenn McConell chats with Professor Herman Pontzer who is a Human Evolutionary anthropologist from Duke University. Herman has undertaken research with current day hunter gather communities and shown that although they are a lot more physically active than western societies, their average energy expenditures are not higher!! Constrained energy model (energy compensation): that when exercise the body constrains other energy use so less change in energy expenditure than would expect. Based on this he has the theory that exercise doesn't affect energy expenditure/body weight. Glenn challenged these ideas and was a devils advocate throughout this discussion. 0:00. Introduction 1:47. Herman was surprised Hadza hunter gathers don't have high energy expenditures 7:39. Others had found dissociations between PA and energy expenditure 8:34. So I ride 1hr/day and walk 10,000 steps but don't expend more energy?! 9:43. Constrained energy model 11:20. Minnesota starvation experiment 14:30. Starvation vs extreme exercise 16:30. Midwest exercise 2 study 17:05. Constrained energy model takes time 18:51. Some people can push past the constrained energy model 21:20. Within subjects vs cross sectional effects re Constrained energy model 23:58. He found higher body fat compensate more with exercise 26:12. Optimal BMI for all cause mortality increasing 28:00. BMR, energy expenditure and the Constrained energy model 32:39. Double labeled water method 35:19. RER and double labeled water method 37:50. Measuring food intake in Hunter gathers 40:02. Given his model, shouldn't athletes that eat a lot put on weight? 42:29. Amount can exercise where overcome Constrained energy model 44:44. Lack of weight loss in exercise studies 49:04. Agree that there must be some energy compensation with exercise 51:12. Relative energy deficiency in sport vs energy compensation 53:40. Exercise and resting metabolic rate 56:09. Cooking potatoes doubles the energy density?! 57:38. He thinks diet determines body weight 1:00:17. Hunger/satiety 1:01:38. Losing weight with exercise and hunger hormones 1:03:21. Genetics x environment re obesity crisis 1:05:58. Hadza don't mix CHO and fat foods 1:07:52. Components that may play a role in the constrained energy model 1:12:41. Outro (9 seconds) Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: glenn.mcconell@gmail.com Subscribe to Inside exercise: Spotify Apple Podcasts Google Podcasts YouTube Anchor Podcast addict Chromecast etc

durée : 00:05:07 - franceinfo junior - Le président Emmanuel Macron a annoncé qu'il souhaitait créer de nouveaux RER dans les grandes villes de France. Olivier Razemon, journaliste au "Monde", spécialiste des transports, répond aux questions des enfants.

Emmanuel Macron veut installer le RER dans les 10 plus grandes villes de France. On en parle avec l'ancien maire de Bordeaux : Alain Juppé.

durée : 00:05:59 - Les Cartes en mouvement - par : Delphine Papin - Dix métropoles françaises devraient bénéficier d'un transport ferroviaire du quotidien de type RER afin de favoriser la transition écologique. Le point en une carte expliquée sur cette annonce présidentielle.

Des RER dans les grandes métropoles de toute la France, c'est ce qu'a annoncé Emmanuel Macron le weekend dernier. Mais Martin va encore plus loin, comme d'habitude. Dans l'appel trop con du jour, il a décidé d'installer des RER en pleine campagne...

EXPERTS DOMINIQUE SEUX Directeur délégué de la rédaction – « Les Echos » BRUNO JEUDY Éditorialiste politique NOÉMIE BERCOFF Spécialiste des questions de mobilité et de transports Société de conseils EGIS ERWAN BENEZET Journaliste au service Économie « Le Parisien – Aujourd'hui en France » « Il croit à fond au train ». Dans une vidéo, postée dimanche sur les réseaux sociaux et reprenant les codes des youtubeurs pour répondre aux questions d'internautes, Emmanuel Macron a dit vouloir doter le pays d'une « grande ambition nationale » : développer un réseau de RER « dans dix métropoles françaises » comme en région parisienne. « C'est un super objectif pour l'écologie, l'économie, la qualité de vie », a lancé le président de la République. Des réseaux de trains express régionaux sur le modèle francilien pour desservir un rayon de 5 à 20 km autour des grandes villes, comme Lille, Lyon, Marseille ou Bordeaux. Les élus disent « chiche », mais encore faut-il que l'Etat les finance. Les présidents de région qui gèrent les transports ont demandé à rencontrer la Première ministre qui sera chargée de « piloter ces grands travaux » pour parler du « nerf de la guerre », l'argent. D'autant qu'en ces temps d'inflation et de crise de l'énergie, les réseaux de transport coûtent déjà bien plus en fonctionnement et les élus ont du mal à boucler leur budget. En Île-de-France, les prix des billets pourraient même flamber à partir du 1er janvier. Dans des documents transmis durant le week-end aux administrateurs d'Île-de-France mobilités, la présidente LR de la région a opté pour le scenario d'un passe Navigo à 90 euros, au lieu de 75,20 euros. Le ticket à l'unité qui coûte aujourd'hui 1,90 euro pourrait passer lui à 2,30 euros. Pour éviter de faire peser sur les usagers l'ensemble des hausses et contenir le prix du passe autour de 80 euros, Valérie Pécresse veut augmenter de la contribution des entreprises qui remboursent la moitié du montant à leurs salariés. Mais la proposition a été rejetée par les sénateurs et l'exécutif. « Le blocage du gouvernement dessine la voie d'un passe Navigo à 90 euros », ce qui serait « socialement inacceptable », a-t-elle écrit. Le bras de fer se poursuit… Au-delà de la question financière, le développement de l'offre de transports est également impacté par un autre problème : la pénurie de chauffeurs. Bus, car, métros, trains… Il manque des milliers de conducteurs pour assurer un service convenable. Selon la Fédération nationale du transport de voyageurs (FNTV), pas moins de 8000 postes de conducteur d'autocar (chiffre à fin août) sont vacants. L'Union des transports publics et ferroviaires (UTP), estime de son côté que 3000 à 4000 postes de chauffeurs de métro, tramway et bus ne sont toujours pas pourvus. Pour faire face, les transporteurs proposent primes et formation accélérée mais le métier attire toujours peu. Or, avec la hausse des prix de l'immobilier dans de nombreuses villes, comme à Biarritz, les habitants sont obligés pour des raisons financières de s'éloigner. Ce qui induit des nouveaux problèmes de mobilité. DIFFUSION : du lundi au samedi à 17h45FORMAT : 65 minutes PRÉSENTATION : Caroline Roux - Axel de Tarlé REDIFFUSION : du lundi au vendredi vers 23h40 RÉALISATION : Nicolas Ferraro, Bruno Piney, Franck Broqua, Alexandre Langeard, Corentin Son, Benoît Lemoine PRODUCTION : France Télévisions / Maximal Productions Retrouvez C DANS L'AIR sur internet & les réseaux : INTERNET : francetv.fr FACEBOOK : https://www.facebook.com/Cdanslairf5 TWITTER : https://twitter.com/cdanslair INSTAGRAM : https://www.instagram.com/cdanslair/

Chaque matin dans son édito, Alexis Brezet, directeur des rédactions du Figaro, revient sur l'actualité politique du jour. Ce mardi, il s'intéresse à la volonté d'Emmanuel Macron de créer des RER dans les plus grandes villes de France.

Chaque matin dans son édito, Alexis Brezet, directeur des rédactions du Figaro, revient sur l'actualité politique du jour. Ce mardi, il s'intéresse à la volonté d'Emmanuel Macron de créer des RER dans les plus grandes villes de France.

Alba Ventura voit d'un très bon oeil l'annonce d'Emmanuel Macron de mettre en place le RER dans dix métropoles du pays. Mais plusieurs questions restent en suspens.

durée : 01:45:50 - Les Matins - par : Guillaume Erner - Emmanuel Macron a annoncé le weekend dernier vouloir développer un réseau de RER dans les dix plus grandes villes françaises. Des projets sont en cours de développement à Bordeaux, Lyon et Toulouse notamment. - invités : Gilles Dansart Journaliste, rédacteur en chef du site Mobilettre et spécialiste du transport ferroviaire

durée : 00:55:07 - Les Informés de franceinfo - Autour de Jean-François Achilli, les informés débattent de l'actualité du lundi 28 novembre 2022.

Cette annonce pourrait bien bouleverser le quotidien de millions de Français pour se déplacer : la mise en place d'un RER, comme à Paris, mais dans les 10 plus grandes métropoles du pays. Une volonté d'Emmanuel Macron dévoilée hier dans une vidéo sur YouTube. Quelles villes seraient concernées ? Combien ça va coûter ?

Une nouvelle promesse signée Emmanuel Macron. Le président de la République a promis des RER dans 10 grandes villes de France. "Pour tenir notre ambition écologique", a dit le président. "Pour limiter les bouchons", il en a fait l'annonce dans une vidéo postée sur Twitter.

Comme il faut faire sentir qu'il entretient une réflexion personnelle sur la question écologique, le président a mis en scène une grande annonce ce 27 novembre : un projet de RER dans 10 grandes villes françaises. Derrière ce projet, quelle vision ?Le magazine Marianne est en kiosques et en ligne chaque jeudi."Le goût de la vérité n'empêche pas de prendre parti". Albert CamusMarianne TV : https://tv.marianne.net/Marianne.net : https://www.marianne.net/ Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

This week Nancy and Kate discuss the tying up syndrome (RER) that appears to affect 8.4% of racehorses. Research Reference: https://www.nzsap.org/system/files/proceedings/trainers-perceptions-impact-different-feeding-and-management-practices-racehorses-they-identified.pdf Wood , LJ, Lancaster, B, Breheny, MR & Rogers, CW 2020, 'Trainers perceptions of the impact of different feeding and management practices on racehorses they identified displaying symptoms of recurrent exertional rhabdomyolysis', Proceedings of the New Zealand Society of Animal Production, vol. 80, pp. 90- 94. --- Send in a voice message: https://anchor.fm/nancy-mclean/message Support this podcast: https://anchor.fm/nancy-mclean/support

L'émission 28 minutes du 8 novembre 2022 Au programme de l'émission du 8 novembre 2021 ⬇ « Armageddon Time » : James Gray raconte les illusions du rêve américain Pour James Gray, "le cinéma doit être une expérience intime". Le réalisateur et scénariste américain s'est  plongé dans son enfance pour son nouveau film "Armageddon Time", qui sort en salles le 9 novembre. Petit-fils d'immigrés russes, James Gray est né et a grandi à New York, où, très jeune, il prend conscience des privilèges de classe, du racisme et des inégalités sociales. Le film explore ces thèmes, et relate l'histoire d'une famille de classe moyenne américaine qui vise l'ascension sociale à tout prix. Très critique avec le cinéma actuel, James Gray nous parlera de sa vision du septième art sur notre plateau.  Transports en commun : mais pourquoi ça craque ? ‘'Zéro métro, zéro RER'' : c'est ce qui se profile pour les utilisateurs des transports en commun en Île-de-France jeudi 10 novembre, journée de grève interprofessionnelle au niveau national. Mais à Paris, c'est depuis la rentrée que les quais de métro sont bondés et les arrêts de bus surchargés. Les conducteurs manquent à l'appel, conséquence de la pandémie, des départs à la retraite non compensés ou encore des problèmes de sécurité sur certaines lignes. Pourtant, la transition écologique supposerait une montée en gamme de l'offre de transports en commun, sachant que le secteur dans son ensemble représente près d'un tiers des émissions de gaz à effet de serre en France. Les investissements de l'État et des collectivités territoriales sont-ils à la hauteur ? Les prix sont-ils assez attractifs ? Comment repenser les transports en commun ? On en débat avec nos invités.  Enfin, retrouvez également les chroniques de Xavier Mauduit et d'Alix Van Pée. 28 Minutes est le magazine d'actualité d'ARTE, présenté par Elisabeth Quin du lundi au vendredi à 20h05. Renaud Dély est aux commandes de l'émission le samedi. Ce podcast est coproduit par KM et ARTE Radio. Enregistrement : 8 novembre 2022 - Présentation : Élisabeth Quin - Production : KM, ARTE Radio

L'invité dans l'actu- La circulation des trains est perturbée ce mercredi en raison d'une grève du personnel de la SNCB. Il proteste contre l'absence de vision dans les chemins de fer et souhaite plus de moyens pour les infrastructures. L'idée de vouloir développer le rail ne date pas d'hier. Le hic : les travaux prennent souvent du retard. Sophie BREMS évoque le projet du RER qui traine depuis plusieurs années. Où en est-on ? Quelles sont les difficultés ? Sont-elles financières ? Pour en parler, le bourgmestre de la Hulpe, Christophe DISTER.

Du lundi au vendredi, Louise Bernard fait le point sur l'actualité des médias. Aujourd'hui, des excuses, un rachat officiel, des suppressions de postes, des financements de bonnes idées et des journaux gratuits dans le métro et le RER.

Du lundi au vendredi, Louise Bernard fait le point sur l'actualité des médias. Aujourd'hui, des excuses, un rachat officiel, des suppressions de postes, des financements de bonnes idées et des journaux gratuits dans le métro et le RER.

On this episode of the podcast, Annie Sargent brings you a conversation with Elyse Rivin of Toulouse Guided Walks as an Introduction to Victor Hugo. Visit the places where Victor Hugo lived There are places you can visit where he lived. The first is the place where he was born: Besançon.  La Maison Natale de Victor Hugo is where you can learn about his progressive political views. The second is on Place des Vosges where he lived for a few years. This is where you can see his standing desk (picture below) and other furnishings of this posh home. Victor Hugo had an immense influence on French politics and was so well-loved that 2 million people came to see his coffin go by on his way to the Pantheon. His was the first "celebrity funeral" as we know them today. Annie loves his works and shares a poem most French people know by heart" Demain dès l'aube" which he wrote in memory of his daughter. He was an exciting man who wrote wonderful novels. France Travel Update For the France travel update, Annie explains why RoissyBus is a good alternative to taking a taxi in Paris. Not as difficult as the RER and about the same price as taking the train. Don't be scared of French buses, they are lovely! This one has AC and WiFi! Recommended in this episode Les Misérables has been adapted many times in movies, plays and Broadway shows. The more adventurous of us might want to read the novel, but it's very long. Perhaps an audio book would be easier to deal with? Les Miserables, unabridged in Audio book in English. Abridged version of Les Miserables on Audible, also in English. This is the unabridged audio book in French Annie is listening to. Demain, dès l'aube in French Demain, dès l'aube, à l'heure où blanchit la campagne, Je partirai. Vois-tu, je sais que tu m'attends. J'irai par la forêt, j'irai par la montagne. Je ne puis demeurer loin de toi plus longtemps. Je marcherai les yeux fixés sur mes pensées, Sans rien voir au dehors, sans entendre aucun bruit, Seul, inconnu, le dos courbé, les mains croisées, Triste, et le jour pour moi sera comme la nuit. Je ne regarderai ni l'or du soir qui tombe, Ni les voiles au loin descendant vers Harfleur, Et quand j'arriverai, je mettrai sur ta tombe Un bouquet de houx vert et de bruyère en fleur. Table of Contents for this Episode [00:00:00] Intro [00:00:41] Today on the podcast [00:02:35] Victor Hugo [00:03:33] Besançon: His birthplace [00:03:50] Places you can visit related to Victor Hugo [00:05:17] Place de Vosges [00:06:41] His Daily Habits [00:07:22] Achieving great success early in life [00:08:21] An author who wrote fast [00:08:47] A prolific author in all genres [00:11:16] Jersey and Guernsey [00:12:05] An Interest in Decoration [00:13:26] A brief recap of Victor Hugo's family history [00:15:01] Affairs on both sides [00:20:11] How his work is being taught in French schools [00:20:56] Enjoying Victor Hugo's novels today [00:21:58] Le Jeux Floraux [00:22:17] Victor Hugo started earning with his writing at a young age [00:23:15] Leopoldine's death [00:25:42] Demain Dès L'aube [00:27:54] His Writing Style [00:36:12] Jean Valjean [00:42:13] His Exile [00:42:54] Victor Hugo was strongly opposed to the death penalty [00:46:37] His return to France [00:47:01] Victor Hugo's Death [00:48:10] He wanted to eradicate poverty [00:49:41] Outro [00:49:41] Thank you, patrons [00:50:13] Shout out to new patrons [00:50:42] Itinerary consults [00:51:26] Self-guided tours [00:51:52] Trevor Noah's VoiceMap tour [00:52:35] Alternative to the RER [00:54:03] EU digital passenger locator form [00:54:41] Personal Update: Bordeaux Rosa Bonheur Exhibition [00:57:31] Next week on the podcast More episodes about French culture FOLLOW US ON: Email | Facebook | Instagram | Pinterest | Twitter

Un En Sol Majeur, et une émission spéciale aujourd'hui, puisqu'on a repris le chemin des RER et autres trains de banlieue pour aller à la rencontre des Chibanis. Cheveux blancs, la soixantaine et plus, ils ont été pour la plupart ces jeunes travailleurs immigrés venus du maghreb et d'Afrique subsaharienne, dont la France a eu besoin pour se reconstruire après la guerre, et puis comme main-d'œuvre dès les années 70. Aujourd'hui, l'heure de la retraite sonne douloureusement : puisque ces oubliés des « trente glorieuses » (environ 110 000 en France) logés par Adoma ex-Sonacotra vivent dans une immense précarité, soutenus Allah y berek par de tenaces réseaux associatifs dont l'ATMF (l'Association des travailleurs maghrébins de France). C'est d'ailleurs dans les locaux de cette association à Gennevilliers, près de Paris, que nous rencontrons ceux qui ont l'élégance de bien vouloir témoigner de leur statut et de leur parcours de vie, ces chibanis qui -je l'avoue- ont un peu le visage de mon grand-père. Ils sont trois avec, par ordre d'apparition, Mohamed Djoumi, Abdellah Moubine (président de l'ATMF) et Mouloud. Musiques diffusées pendant l'émission Meskoud Abdelmajid El Assima Rachid Taha Ya rayah Idir Vava inouva (Rediffusion du 7 juillet 2020)

Jennifer Jerzyk, my guest on today's podcast visited Narbonne and the Mediterranean coast in 2022. She travelled mostly by train because she finds it peaceful and relaxing. She also enjoyed the fact that Narbonne is a great gateway into the Mediterranean and such value! That's because Narbonne is not touristy. As a matter of fact, she wondered if she was the only tourist there! For the travel question of the week, Annie explains why people who take the RER between the airport and the city are asking for trouble. That's 49 minutes into the episode and you should listen to it and heed my advice! Tips for a Visit to Narbonne and the Mediterranean Coast Narbonne is a great place from which to explore the "other Riviera". The Mediterranean coast between Montpellier and Collioure. For example you could go to Agde, Sète, Port Vendres, Banyuls-sur-Mer, etc. Some of these places don't have a train station, but you might get there on a regional bus or by renting a car. Recommended in this Episode For your own peace of mind, you may want to lock your suitcase to the travel rack using a retractable lock. You can see one in Annie's Join Us in France Favs. L'estagnol Restaurant in Narbonne where they serve wonderful seafood and where she also went back for a wine event hosted by the wine maker. Hôtel de la Cité or Best Western in Carcassonne. Restaurant La Voile in Collioure In the conversation we mentioned Les Grands Buffets but they've since announced that the restaurant is moving but haven't announced where yet. Stay tuned, I will talk about it once the move has happened. More episodes about Occitanie

En 1990, toute la Suisse a les yeux rivés sur le canton de Zurich, qui inaugure le premier RER du pays. Ce Réseau Express Régional, ou "S-Bahn" comme on l'appelle outre-Sarine, va révolutionner la façon de se déplacer dans le canton. Envié par la Suisse romande, le RER alémanique va inspirer la création de réseaux régionaux romands, à l'instar du RER fribourgeois ou plus récemment du Léman Express. Pour revenir sur cet épisode-clé du développement du rail en Suisse, Noémie Guignard a rencontré à Zurich Walter Finkbohner, spécialiste des transports publics. Dimanche 26 juin à 20h55, vous pourrez voir le documentaire "Les CFF, hier, aujourd'hui et demain", réalisé par Hans Jürg Zumstein (Suisse, 2022) Résumé: Ce documentaire brosse le portrait de l'une des grandes entreprises du service public suisse. Nous cheminerons sur les décombres du rail privé, depuis la création des CFF, en 1889, jusqu'aux défis relevés par les transports publics européens, entre protection du climat et numérisation. Photo: train FLIRT, circulant couramment sur le RER fribourgeois. La mise en service du RER Fribourg | Freiburg a eu lieu la 11 décembre 2011 avec un train direct (RE) reliant Bulle, Romont et Fribourg toutes les demi-heures, et avec un prolongement jusqu'à Berne chaque heure. (© flybyeigenheer/flickr)

In this episode we fast-forward to this very moment, wade chest-deep into the breastmilk v formula debate, reflect on the second RER appearance of Justus von Liebig, and reach for the emergency handbrake on the runaway freight train that is our economic system. HV reminds us of the treasure chest inside of all of us and Rambo delegates humor as the highest level of communication, as we attempt to decentralize the conversation around blockchain technology, scrutinize the devaluation of artistic expression, and sift through the shallow history of credit & debt.   No show would be complete without a reminder that generosity is the key to abundance and that there is no shortage, only a hidden hand on the hose constricting the flow.   Wish HV luck as she does her damndest to Keep Austin Weird...   Enjoy! --- Follow us on Patreon for more in-depth analysis and matrix-cracking insights from the minds of HV & Rambo.   Follow HV on twitter @humanvibration and insta @humanvibration_insta   Follow Rambo on twitter @Seekthetruth101 and insta @rambo_seekthetruth101   Music by AYZ @Ayz, and a special shoutout to *THE UNIVERSE* for sponsoring Episode 5 of Season 2.

durée : 00:53:13 - LSD, la série documentaire - par : Perrine Kervran, Kristel Le Pollotec - KNUT, PRUT, GOTA, PAPY, ou l'épopée du RER.

durée : 00:53:16 - LSD, la série documentaire - par : Perrine Kervran, Kristel Le Pollotec - Déambulation sonore dans les dédales du RER où l'on retrouvera les igloos et la voute céleste d'Auber, les confessionnaux de Nation et le Midnight Express de la Défense.

durée : 00:54:06 - LSD, la série documentaire - par : Perrine Kervran, Kristel Le Pollotec - Depuis le château de la Belle au bois dormant à Marne-la-Vallée jusqu'aux terrasses du château de Saint-Germain-en-Laye, une traversée est-ouest à bord du RER A, comme une réminiscence des trains de loisirs du XIXe siècle…

durée : 00:53:38 - LSD, la série documentaire - par : Perrine Kervran, Kristel Le Pollotec - Parcours Nord-Sud sur le RER B, depuis la Plaine-Saint-Denis aux rives bucoliques de l'Yvette.

On this episode of the podcast, Jennifer Gruenke tells us about her 7 day trips from Paris on public transportation. She went to Rambouillet, Auvers-sur-Oise, Fontainebleau, Saint-Cloud, Saint-Germain-en-Laye, Provins, and Versailles all in the same week! Which one was her favorite? Click play to hear all about it! Episode Page | Guest Notes | Transcript Table of Contents for this Episode [00:00:40] A conversation with Jennifer Gruenke about her 7 day trips from Paris [00:02:45] Rambouillet, Auvers-sur-Oise, Fontainebleau, Saint-Cloud, Saint-Germain-en-Laye, Provins, and Versailles [00:03:49] Getting a week-long Navigo Pass [00:04:35] Taking a different day trip from Paris every day [00:05:32] Day trip to Rambouillet [00:10:51] Chateau gardens are often free [00:11:20] Versailles gardens on fountain days [00:13:48] More people willing to speak French with visitors outside of Paris [00:14:24] Rambouillet gets a 7/10 from Jennifer [00:15:09] Auvers-sur-Oise, the town where Van Gogh lived at the end of his life [00:15:41] Finding Van Gogh Podcast [00:15:54] Go to the Orsay Museum then go to Auvers-sur-Oise [00:17:10] Lookout for things to be closed on Mondays or Tuesdays [00:18:06] Van Gogh plus in Auvers-sur-Oise [00:19:26] Fontainebleau [00:20:47] Are these all easy to get to once you get off the train? [00:22:41] Domaine National de Saint Cloud [00:24:29] Virtual Reality at Saint Cloud [00:29:49] Saint Germain en Laye [00:32:58] Provins [00:38:13] Bring ID in exchange for audio guide [00:39:15] Bring cash and toilet paper to Provins [00:42:45] Versailles gardens only: enter at Allée des Matelots [00:44:54] The RER to Versailles is often really crowded! [00:48:31] Ranking these 7 day trips from Paris [00:50:41] Seeing French Chateaux without going to the Loire Valley [00:51:29] Lyon and other cities are not far from Paris on the TGV [00:54:31] Thank you patrons and donors [00:58:53] Travel Tip: Can you ask for a doggy bag in France? [01:00:19] This week in French news [01:01:35] Annie's personal update [01:02:42] Use the search button on Join Us because there are a lot of episodes! [01:03:12] Share the podcast with a fellow Francophile [01:04:11] Next week on the podcast an episode about the Cathars and their strange theology More episodes about day-trips from Paris

C'est comme un repas de fin d'année permanent. Les débats houleux s'enchaînent : élections, vaccin, guerre… Les sujets de crispation se multiplient, et les liens se fragilisent. À la liste de nos soucis personnels et fragmentés, s'ajoutent des événements majeurs qui nous touchent simultanément. Et malgré des différences de situations et de conséquences sur chacun·e d'entre nous, ces moments génèrent des émotions puissantes et partagées. Épuisé·e·s, à fleur de peau, la pandémie a mis à l'épreuve notre patience et notre seuil de tolérance. La “distanciation” a eu des répercussions multiples, exacerbé des tensions pré-existantes et mis à mal le tissu social. Comment en est-on arrivé là ? Quelles conséquences cet état de nervosité a-t-il eu sur nos relations et comment fait-on aujourd'hui pour réapprendre ensemble à aller mieux ? Pour cet épisode, la journaliste Estelle Ndjandjo donne la parole à des travailleuses en première ligne : Laura, conductrice de RER et Mélissa, infirmière, qui témoignent du bouleversement qu'a provoqué la pandémie dans leurs vies. Afin de comprendre les mécanismes en jeu dans des états de crise, Estelle Ndjandjo fait aussi appel à deux expert·e·s. Laurence Kaufman, professeure de sociologie qui a co-dirigé l'ouvrage Les Émotions collectives, analyse les implications politiques et sociales du passage d'une émotion individuelle à une émotion partagée. Pierre Faubert, psychoclinicien, s'intéresse à la manière dont la crise sanitaire a modifié notre relation aux autres et notre communication. Un épisode que vous pouvez écouter seul·e ou en famille. Émotions est un podcast de Louie Media présenté par Brune Bottero. Cet épisode a été tourné et monté par Estelle Ndjandjo. Marine Quéméré en a fait la réalisation. Benoît Daniel s'est occupé de la prise de son. Jean-Baptiste Aubonnet a fait le mixage de cet épisode. Le générique a été composé par Nicolas de Gélis. Camille Bichler et Marie-Lou Arnould étaient en charge de la production de cet épisode, accompagnée de Marie Koyouo. La supervision éditoriale était assurée par Maureen Wilson.La retranscription de cet épisode est bientôt disponible.Suivez Louie Media sur Instagram, Facebook, Twitter.Et si vous souhaitez soutenir Louie, n'hésitez pas à vous abonner au Club. Vous y trouverez des bonus, une newsletter, des masterclass, des rencontres avec l'équipe, et bien plus. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out.

C'est comme un repas de fin d'année permanent. Les débats houleux s'enchaînent : élections, vaccin, guerre… Les sujets de crispation se multiplient, et les liens se fragilisent. À la liste de nos soucis personnels et fragmentés, s'ajoutent des événements majeurs qui nous touchent simultanément. Et malgré des différences de situations et de conséquences sur chacun·e d'entre nous, ces moments génèrent des émotions puissantes et partagées. Épuisé·e·s, à fleur de peau, la pandémie a mis à l'épreuve notre patience et notre seuil de tolérance. La “distanciation” a eu des répercussions multiples, exacerbé des tensions pré-existantes et mis à mal le tissu social. Comment en est-on arrivé là ? Quelles conséquences cet état de nervosité a-t-il eu sur nos relations et comment fait-on aujourd'hui pour réapprendre ensemble à aller mieux ? Pour cet épisode, la journaliste Estelle Ndjandjo donne la parole à des travailleuses en première ligne : Laura, conductrice de RER et Mélissa, infirmière, qui témoignent du bouleversement qu'a provoqué la pandémie dans leurs vies. Afin de comprendre les mécanismes en jeu dans des états de crise, Estelle Ndjandjo fait aussi appel à deux expert·e·s. Laurence Kaufman, professeure de sociologie qui a co-dirigé l'ouvrage Les Émotions collectives, analyse les implications politiques et sociales du passage d'une émotion individuelle à une émotion partagée. Pierre Faubert, psychoclinicien, s'intéresse à la manière dont la crise sanitaire a modifié notre relation aux autres et notre communication. Un épisode que vous pouvez écouter seul·e ou en famille. Émotions est un podcast de Louie Media présenté par Brune Bottero. Cet épisode a été tourné et monté par Estelle Ndjandjo. Marine Quéméré en a fait la réalisation. Benoît Daniel s'est occupé de la prise de son. Jean-Baptiste Aubonnet a fait le mixage de cet épisode. Le générique a été composé par Nicolas de Gélis. Camille Bichler et Marie-Lou Arnould étaient en charge de la production de cet épisode, accompagnée de Marie Koyouo. La supervision éditoriale était assurée par Maureen Wilson.La retranscription de cet épisode est bientôt disponible.Suivez Louie Media sur Instagram, Facebook, Twitter.Et si vous souhaitez soutenir Louie, n'hésitez pas à vous abonner au Club. Vous y trouverez des bonus, une newsletter, des masterclass, des rencontres avec l'équipe, et bien plus. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out.

Christophe Hondelatte raconte l'année 1995 en puisant dans les archives d'Europe 1. Cette année-là… une secte attaque le Japon, une bombe dans le RER parisien, Bernard Tapie condamné à aller en prison, un indien dans la ville au cinéma ! Et les Inconnus qui cartonnent.

Real Eyes Radio is reporting for duty with a frontline, backstage report from our friend, fellow patron, and intrepid seeker of the Truth @LezLuthor. Rambo and HV watch excitedly from the wings as Lez takes an icepick to the back wall of the War Theater in Ukraine. Through Lez' first-hand, boots0on-the-ground journalism, we've been granted our very own set of Real Eyes to collectively witness the Truth -- our most important and valuable weapon in this imaginary war. This is truly a proud and monumental moment in RER history, with one of our very own pulling back the stage curtains for thousands to see... Lez' work is the most important journalism happening right now, period. Enjoy! --- This episode is from our Real Eyes Radio Patreon channel, with fresh content every week patreon.com/realeyesradio   Follow Lez on twitter @LezLuthor and support him on Patreon patreon.com/LezLuTHOR