Podcasts about cellular physiology

Thank you for tuning in to this episode of the MHS Podcast with Dr. Alexander Hutchison!! ⁠⁠In Defence of Doping BOOK⁠⁠ IG @the_professor_hutchison LinkedIN GOODEGG.FTINESS Through this groundbreaking work, Dr. Hutchison offers a thought-provoking reassessment of conventional notions surrounding performance enhancement in athletics. His distinguished academic background includes serving as the Editor-in-Chief for the esteemed ⁠⁠Journal of Cellular Physiology⁠⁠, where he continues to shape scholarly discourse on exercise science, nutrition, and immunology. In addition to key note speaking at events such as ⁠⁠the National Strength & Conditioning Association conference⁠⁠. Hutchison's athletic journey is equally impressive, from his collegiate swimming career to his success as a coach, guiding athletes to triumph in Ironman triathlons and prestigious marathons like the Boston Marathon. Drawing upon his firsthand experiences and scholarly insights, Dr. Hutchison can delve into the historical precedents and contemporary realities of performance enhancement, challenging prevailing narratives and advocating for a nuanced understanding of the ethical implications at play. Dr. Alexander Hutchison brings his expertise to the forefront in discussions on the ethics of doping in sports. Through his work, he continues to push the boundaries of conventional discourse, offering fresh perspectives and insights that resonate deeply with athletes, scholars, and enthusiasts alike. He can speak to the following topics:  The reason there needs to be a far more holistic approach to performance enhancement in sport and defining more clearly the parameters. Why test sensitivity & contamination needs to be acknowledged more acutely - Positive results can be obtained through food, drink, prescribed drugs & even sexual activity. Cannabis or Can'tabis - Tone deaf bans & disqualification based on inaccurately claimed competitive advantages of drugs such as Cannabis. Why PEDs should be used for athletes to speed up recovery and prevent injuries. Support the Show Click a Link BelowBelow

Dr Alexander Hutchison has a PHD in Exercise and Physiology and has worked as editor in chief for Journal of Cellular Physiology and now editor in chief of Current Protocols. His book In Defense of Doping has people thinking about performance enhancing drugs in a different way. He goes into understanding why someone would take a drug, the drug scandals throughout the years. We also talk about the new protocols of enhancing performance, TRT and how that is a benefit for people.   Need Personal Workouts & Coaching? On-site and off-site Solutions Available. Visit www.thinkfitnesslife.com for more information.

Dr. Alexander Hutchison, a prominent figure in fitness and wellness based in Dallas, Texas, stands at the forefront of discussions surrounding doping in sports with the release of his third book, "In Defense of Doping: Reassessing the Level Playing Field." Through this groundbreaking work, Dr. Hutchison offers a thought-provoking reassessment of conventional notions surrounding performance enhancement in athletics. His distinguished academic background includes serving as the Editor-in-Chief for the esteemed Journal of Cellular Physiology, where he continues to shape scholarly discourse on exercise science, nutrition, and immunology. Hutchison's athletic journey is equally impressive, from his collegiate swimming career to his success as a coach, guiding athletes to triumph in Ironman triathlons and prestigious marathons like the Boston Marathon. Drawing upon his firsthand experiences and scholarly insights, Dr. Hutchison can delve into the historical precedents and contemporary realities of performance enhancement, challenging prevailing narratives and advocating for a nuanced understanding of the ethical implications at play. Dr. Alexander Hutchison brings his expertise to the forefront in discussions on the ethics of doping in sports. Through his work, he continues to push the boundaries of conventional discourse, offering fresh perspectives and insights that resonate deeply with athletes, scholars, and enthusiasts alike. Work with RAPID Health Optimization Work with Dr. Alexander Hutchinson Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram

Dr. Alexander Hutchison is a prominent figure in health and fitness, standing at the forefront of discussions surrounding doping & PED's in sports and fitness with the release of his third book, In Defense of Doping: Reassessing the Level Playing Field. He serves as the Editor-in-Chief for the Journal of Cellular Physiology. Dr. Hutchison was a collegiate swimmer and then a coach, guiding athletes to triumph in Ironman triathlons and races like the Boston Marathon.  https://a.co/d/0bb2XYT7 https://www.linkedin.com/in/alexander-hutchison-8687aa223/   LMNT is offering a free sample pack along with any regular purchase when you use my custom link www.drinklmnt.com/carnivorecast. The LMNT Sample Pack includes 1 packet of every flavor. This is the perfect offer for 1) anyone who is interested in trying all of our flavors or 2) wants to introduce a friend to LMNT. Go to www.drinklmnt.com/carnivorecast to claim this awesome deal! And check out the new LMNT Sparkling — a bold, 16-ounce can of sparkling electrolyte water.   Get the best beef jerky I've ever had!

Today, I sat down with Dr. Brian Kobilka, Professor in the Department of Molecular and Cellular Physiology at Stanford University School of Medicine. Dr. Kobilka is an expert on a class of receptors called G protein-coupled receports, or GPCRs, that are essential in a majority of biological processes including light, flavor, and odor perception and in the activity of adrenalin, dopamine, and serotonin. In fact, currently approximately half of all pharmaceuticals on the market target GPCRs. In the mid 1980s Dr. Kobilka and his colleagues from the Robert Lefkowitz lab were the first to clone the gene for an important GPCR called the beta2-adrenergic receptor, and later he and his collaborators were the first to determine its molecular structure, which served as the basis for understanding all subsequent GPCRs and creating drugs to target them. This work proved to be revolutionary in many areas of science and medicine, such that in 2012, Kobilka was awarded the Nobel Prize in Chemistry for his contributions to understanding GPCRs. In this interview, we talk about these amazing findings and the recent advances in understanding this important class of receptors. Title music: World Is Holding Hands by WinnieTheMoog https://creativecommons.org/licenses/by/4.0/legalcode

In this episode, hosts Lesley and Jeremy speak with Dr. Jennifer Lippincott-Schwartz, Senior Group Leader and Head of Janelia's 4D Cellular Physiology Group, about how technology has shaped her career and her vision for developing a molecular understanding of tissue physiology. Episode Notes: Please help us create content you want to hear by giving us feedback. https://www.mpfi.org/news-media/podcast-survey/ Episode Guest: Jennifer Lippincott-Schwartz - @JLS_Lab Episode Hosts: Lesley Colgan - @Colgan_Lesley Jeremy Chang - @jtchang Do you enjoy the podcast? Feel free to like this episode and follow us to hear more episodes! https://apple.co/43gT3hT https://sptfy.com/O7ny Max Planck Florida's Neurotransmissions Podcast Website: https://www.mpfi.org/news-media/podcast Social Media: @MPFneuro Twitter: / mpfneuro Instagram: / mpfneuro Facebook: / mpfneuro

Learn about grafting compatibility and what kinds of trees can be grafted together by understanding the science of graft unions! Our guest is Dr Kevin Folta, Professor of horticultural sciences at the University of Florida.The host of the Orchard People radio show and podcast is Susan Poizner of the fruit tree care education website www.orchardpeople.com.  Tune into The Urban Forestry Radio Show LIVE by going to RealityRadio101.com on the last Tuesday of every month at 1.00 pm Eastern Time or download the podcast. Learn to grow organic fruit trees successfully. Sign up for OrchardPeople.com's premium online courses at https://learn.orchardpeople.com/. (00:00) - Introduction (01:44) - Episode #100 information (03:33) - What is fruit tree grafting (04:37) - Does grafting happen in nature? (08:00) - Why are some fruit tree cultivars easy to graft with than others? (11:17) - Plant Morphology and Fruit Tree Grafting (14:56) - Cellular Physiology and Grafting (19:20) - Kevin's Podcast (20:47) - Can you graft flowering plants and non-woody plants? (21:58) - Do you need to pay royalties when using scion cuttings? (25:21) - Can you graft zone 5 apples onto a zone 4 rootstock? (27:23) - Sponsors (31:39) - Part 2 (32:46) - Plant hormones and fruit tree grafting (37:31) - Grafting and Taxonomy (39:08) - Molecular biology and fruit tree grafting (42:46) - Cherry trees and fruit tree grafting compatibility (44:09) - Grafting vs Budding and stone fruit trees (45:54) - Grafting chestnut trees onto oak trees? (47:06) - Grafting Pear onto Quince (49:56) - Grafting European Pears onto Various Rootstocks (52:03) - Citation rootstock in California vs Florida (54:59) - Why Kevin Loves Grafting (57:15) - Access more grafting and fruit tree resources

Episode 146: RA vs OA    Future Dr. Magurany explains how to differentiate rheumatoid arthritis from osteoarthritis.  Written by Thomas Magurany, MSIV, Ross University School of Medicine. Comments by Hector Arreaza, MD. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.1. Etiology: Rheumatoid Arthritis (RA): RA is an autoimmune disease wherein the immune system mistakenly attacks healthy tissues, particularly the synovial joints, usually between the ages of 30-50. Genetic predisposition, environmental factors such as smoking or infections, hormonal imbalances, and lower socioeconomic status have been associated with an increased risk of developing RA(1).Osteoarthritis (OA): OA primarily arises due to mechanical stress on the joints over time. Factors contributing to OA include age, obesity, joint injury or trauma, repetitive joint use or overuse, genetic abnormalities in collagen structure, and metabolic disorders affecting cartilage metabolism (2).The greatest risk factor for the development of OA is age with most patients presenting after 45 years of age. The greatest modifiable risk factor for OA is weight. People with a BMI >30 were found to have a 6.8 times greater risk of developing OA. (3) Primary OA is the most common and is diagnosed in the presence of associated risk factors such as: older age, female gender, obesity, anatomical factors, muscle weakness, and joint injury (occupation/sports activities) in the absence of trauma or disease. Secondary OA occurs alongside a pre-existing joint deformity including trauma or injury, congenital joint disorders, inflammatory arthritis, avascular necrosis, infectious arthritis, Paget disease, osteopetrosis, osteochondritis dissecans, metabolic disorders (hemochromatosis, Wilson's disease), Ehlers-Danlos syndrome, or Marfan syndrome.2. Pathogenesis:Rheumatoid Arthritis (RA):In some patients, RA is triggered by some sort of environmental factor in a genetically predisposed person. The best example is tobacco use in a patient with HLA-DRB1. The immune response in RA starts at sites distant from the synovial joints, such as the lung, gums, and GI tract. In these tissues, modified proteins are produced by biochemical reactions such as citrullination. (4)In RA, an abnormal immune response leads to chronic inflammation within the synovium lining the joints. The inflammatory cytokines released cause synovitis and lead to the destruction of articular cartilage and bone erosion through pannus formation. Immune cells infiltrate the synovium causing further damage. (4) In summary: formation of antibodies to citrullinated proteins, these antibodies begin attacking wrong tissues.Osteoarthritis (OA):The primary pathological feature of OA is the degeneration of articular cartilage that cushions the joints causing surface irregularity, and focal erosions. These changes progress down the bone and eventually involve the entire joint surface. Mechanical stress triggers chondrocyte dysfunction, leading to an imbalance between cartilage synthesis and degradation that cause cartilage outgrowths that ossify and form osteophytes. This results in the release of enzymes that degrade the extracellular matrix, leading to progressive cartilage loss. As more of the collagen matrix is damaged, chondrocytes undergo apoptosis. Improperly mineralized collagen causes subchondral bone thickening; in advanced disease, bone cysts infrequently occur (5). In summary: Osteophytes formation and cartilage loss.3. Clinical Presentation:Rheumatoid Arthritis (RA):The most common and predominant symptoms include joint pain and swelling, usually starting insidiously over a period of weeks to months. RA typically affects multiple joints symmetrically, commonly involving small joints of the hands, wrists, feet and progresses to involve proximal joints if left untreated. Morning stiffness lasting more than an hour is a characteristic feature. The affected joint will be painful if pressure is applied to the joint or on movement with or without joint swelling. Synovial thickening with a "boggy" feel on palpation will be noted. The classical physical findings of ulnar deviation, metacarpophalangeal joint subluxation, swan neck deformity, Boutonniere deformity, and the "bowstring" sign (prominent and tight tendons on the dorsum of the hand) are seen in advanced chronic disease. (4) Around ¼ of patients with RA may present with rheumatoid noduleswhich are well demarcated, flesh-colored subcutaneous lumps. They are usually described as being doughy or firm and are not typically tender unless they are inflamed. They are usually found on areas susceptible to repeated trauma or pressure and include the elbows, fingers and forearms. Osteoarthritis (OA):OA primarily affects weight-bearing joints such as knees, hips, spine, and hands. Symptoms include joint pain aggravated by activity and relieved with rest, morning stiffness lasting less than 30 minutes, joint swelling due to secondary inflammation, and occasionally the formation of bony outgrowths called osteophytes (6). Tenderness may be present at joint lines, and there may be pain upon passive motion. Classic physical exam findings in hand OA include Heberden's nodes (posterolateral swellings of DIP joints), Bouchard's nodes (posterolateral swellings of PIP joints), and “squaring” at the base of the thumb (first Carpal-Metarcapal or CMC joints), bony enlargement, crepitus, effusions (non-inflammatory), and a limited range of motion. Patients may also experience bony swelling, joint deformity, and instability (patients complain that the joint is “giving way” or “buckling,” a sign of muscle weakness). (5)4. Lab findings:Rheumatoid Arthritis: Laboratory testing often reveals anemia of chronic disease (increased ferritin, decreased iron and TIBC) and thrombocytosis. Neutropenia may be present if Felty syndrome is present. RF is present in 80-90% of patients with a sensitivity of 69%. In patients who are asymptomatic or those that have arthralgias, a positive RF and especially CCP predicts the onset of clinical RA. Patients with RA with RF, ACPA, or both are designated as having seropositive RA. About 10% of RA patients are seronegative. ESR and levels of CRP are usually elevated in patients with active disease and can be used to assess disease activity. The synovial fluid in RA will also reveal low C3 and C4 levels despite elevated serum levels.(4) Some non-specific inflammatory markers such as ESR, CRP can help you guide your diagnosis of RA.Osteoarthritis:Lab findings are not significant. Clinical diagnosis if the following are present: 1) pain worse with activity and better with rest, 2) age more than 45 years, 3) morning stiffness lasting less than 30 minutes, 4) bony joint enlargement, and 5) limitation in range of motion. Blood tests such as CBC, ESR, rheumatoid factor, ANA are usually normal but usually ordered to rule out an inflammatory process. Synovial fluid should show a white blood cell count less than 2,000/microL, predominantly mononuclear cells (non-inflammatory). X-rays of the affected joint can show findings consistent with OA, such as marginal osteophytes, joint space narrowing, subchondral sclerosis, and cysts; however, radiographic findings do not correlate to the severity of the disease and may not be present early in the disease. (5)5. Treatment Approaches:Rheumatoid Arthritis (RA):There is no cure for RA.The goal of treatment in RA is inducing remission and optimizing quality of life. This is initially done by beginning DMARDs, include methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide. Methotrexate is the initial DMARD of choice. Anti-TNF-alpha inhibitors include etanercept, infliximab, adalimumab, golimumab, and certolizumab may be used if DMARDs fail. NSAIDs are used to control joint pain and inflammation. Corticosteroids may be used as a bridge therapy to DMARDs in a newly diagnosed patient with a very active disease. (7) Coronary artery disease has a strong association with RA. RA is an independent risk factor for the development of coronary artery disease (CAD) and accelerates the development of CAD in these patients. Accelerated atherosclerosis is the primary cause of morbidity and mortality. There is increased insulin resistance and diabetes mellitus associated with RA and is thought to be due to chronic inflammation. When treated with specific DMARDs such as hydroxychloroquine, methotrexate, and TNF antagonists, there was a marked improvement in glucose control in these patients. (8) RA is not just a disease of the joints, it is able to affect multiple organ systems.Osteoarthritis (OA):OA treatment aims at reducing pain and improving joint function through a combination of non-pharmacological interventions like exercise programs tailored to strengthen muscles around affected joints, weight management strategies, and assistive devices like braces or walking aids if required (9). Medications including analgesics or nonsteroidal anti-inflammatory drugs may be prescribed for pain relief when necessary. Duloxetine has modest activity in relieving pain associated with OA. Intraarticular glucocorticoid joint injections have a variable response but are an option for those wanting to postpone surgical intervention. In severe cases where conservative measures fail, surgical options like joint replacement may be considered (9). Weight loss is a critical intervention in those who have overweight and obesity; each pound of weight loss can decrease the load across the knee 3 to 6-fold. (5) Summary: Medications (NSAIDs, topical, duloxetine), weight loss, PT, intraarticular injections of corticosteroids, and joint replacement.________________________________Conclusion: Now we conclude episode number 146, “RA vs. OA.” Future Dr. Magurany explained that rheumatoid arthritis is an autoimmune disease that presents with joint pain and inflammation, mostly on hands and small joints, accompanied by morning stiffness longer than 1 hour. The rheumatoid factor and ACPA may be positive in a percentage of patients but not always. The base of treatment is early treatment with disease-modifying antirheumatic drugs to induce remission of the disease. OA affects weight-bearing joints with little to no inflammation, treatment is mainly lifestyle modifications, analgesics, intraarticular injections, and joint replacement.This week we thank Hector Arreaza and Thomas Magurany. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Myasoedova E, Crowson CS & Gabriel SE et al. (2010). Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955-2007. Arthritis and Rheumatism, 62(6), 1576-1582.Goldring MB & Goldring SR. (2007). Osteoarthritis. Journal of Cellular Physiology, 213(3), 626-634.King LK, March L, Anandacoomarasamy A. Obesity & osteoarthritis. Indian J Med Res. 2013;138(2):185-93. PMID: 24056594; PMCID: PMC3788203.Chauhan K, Jandu JS, Brent LH, et al. Rheumatoid Arthritis. [Updated 2023 May 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.Sen R, Hurley JA. Osteoarthritis. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.Hunter DJ, Bierma-Zeinstra S. & Eckstein F. (2014). OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for primary hip and knee osteoarthritis: An expert consensus initiative of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Task Force in collaboration with the Osteoarthritis Research Society International (OARSI). Osteoarthritis Cartilage, 22(7), 363-381.van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW. Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med. 2002 Jan 1;136(1):1-12. doi: 10.7326/0003-4819-136-1-200201010-00006. PMID: 11777359.Nicolau J, Lequerré T, Bacquet H, Vittecoq O. Rheumatoid arthritis, insulin resistance, and diabetes. Joint Bone Spine. 2017 Jul;84(4):411-416.Fernandes L, Hagen KB, Bijlsma JWJ et al. (2019). EULAR recommendations for non-pharmacological core management of hip and knee osteoarthritis. Annals of Rheumatic Diseases, 79(6), 715-722.Royalty-free music used for this episode: "Driving the Point." Downloaded on July 29, 2023, from https://www.videvo.net/ 

Like a lot of kids, Anurag Sakharkar used to dream about being a doctor, or an astronaut. His parents, both academics, encouraged him to follow his dream.   In high school, he began spending evenings and weekends working at the University of Saskatchewan's biomedical labs, perfecting advanced research methods, western blots and PCR analysis . He began learning about Parkinson's disease with Dr. Changiz Taghibiglou, then started examining novel cancer treatment approaches with Dr. Franco Vizeacoumar.   The Covid-19 pandemic brought Anu's in-person laboratory time to an abrupt halt. Undeterred, he began to spend his nights poring over gene expression data, using computational analysis to identify patterns.   “We integrated all these different methods and looked at the genome coordination as a whole,” said Anu. “What important pathways are involved, and how do they connect and interact at the DNA, protein, and RNA levels?”   His curiosity spread from analyzing biomarkers in cancer cells — to learning more about the dramatic changes occurring in an astronaut's body during space flight.   Astronauts lose bone density and muscle mass in space. They endure neurological degeneration, renal and cardiovascular dysfunction, compromised immunity, and upon their return to earth they have a far higher risk of developing cancer. Anu noticed a more large-scale inherent change in these astronauts in his research.   “You see gene correlation and coordination breaking down all over the entire genome,” said Anu. “You have a huge systemic trauma that's occurring in these astronauts when they go into space.”   Together with Dr. Jian Yang from the College of Pharmacy and Nutrition, Anu started analyzing astronaut gene expression data gathered in NASA's open-source GeneLab. It tracked eight men and two women posted to the International Space Station for a six-month period, including pre-flight, inflight, and postflight measurements.   Anu developed a novel expression analysis method, and has now identified 32 genes with outsized effects on astronauts' health as possible candidates for biomarkers to characterize, monitor, and even treat health issues.   In February, his research was published in Life. With support from the University of Saskatchewan President's NSERC Research Fund, it also formed a partial basis of Anu's honours thesis as he completes his final undergraduate year this spring, majoring in Cellular Physiology and Pharmacology.   He's developed partnerships with universities around the world, along with NASA, the Canadian Space Agency, and private space bioscience companies.   “Space is definitely humanity's future,” Anu said. “That future is getting closer and closer."

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.30.521121v1?rss=1 Authors: Studtmann, C., Ladislav, M., Safari, M., Chen, Y., Topolski, M. A., Khondaker, R., Tomovic, E., Balik, A., Swanger, S. A. Abstract: Somatosensory information is propagated from the periphery to the cerebral cortex by two parallel pathways through the ventral posterolateral (VPL) and ventral posteromedial (VPM) thalamus. VPL and VPM neurons receive somatosensory signals from the body and head, respectively. VPL and VPM neurons also receive cell-type-specific GABAergic input from the reticular nucleus of the thalamus (nRT). Although VPL and VPM neurons have distinct connectivity and physiological roles, differences in the functional properties of VPL and VPM neurons remain unclear as they are often studied as one ventrobasal (VB) thalamus neuron population. Here, we directly compared synaptic and intrinsic properties of VPL and VPM neurons in C57Bl/6J mice of both sexes aged P25-P32. Recordings of spontaneous synaptic transmission suggested that VPL neurons receive excitatory synaptic input with higher frequency and strength than VPM neurons, while VPL neurons exhibited weaker inhibitory synapse strength than VPM neurons. Furthermore, VPL neurons showed enhanced depolarization-induced spike firing and greater spike frequency adaptation than VPM neurons. VPL and VPM neurons fired similar numbers of spikes during hyperpolarization rebound bursts, but VPM neurons exhibited shorter burst latency compared to VPL neurons, which correlated with increased sag potential during hyperpolarization. This work indicates that VPL and VPM thalamocortical neurons are functionally distinct populations. The observed functional differences could have important implications for their specific physiological and pathophysiological roles within the somatosensory thalamocortical network. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Video: Interview with Dr. Rupert Sheldrake (41:21) Stomach cancer cells halted with whole tomato extracts Sbarro Institute for Molecular Medicine at Temple University  October 10, 2022 The Mediterranean diet has become regarded as highly beneficial to overall health, maintaining ideal weight and a reduced risk of cancer plus many other chronic disease conditions. One of the staples of this diet is tomatoes, especially the low-acid varieties that are grown in Italy and its impact on cancer risk is quite interesting. Recent research by the Sbarro Institute for Molecular Medicine at Temple University in Philadelphia, Pa. has confirmed that two tomato cultivars grown in Southern Italy inhibit both malignant features and cellular growth in stomach cancer cells. For the study, whole tomato lipophilic extracts were analyzed for their ability to fight and diminish neoplastic features of stomach cancer cells. Both the Corbarino and San Marzano tomato varieties were found to inhibit the cloning behavior of malignant cancer cells as well as impede their growth. When tomato extracts were used on stomach cancer cells, key processes related to cell development, migration and proliferation were inhibited. The tomato extracts ultimately induced apoptosis, or cancer cell death in cancer cells. The study results were published in the Journal of Cellular Physiology. Significantly, the tomato extracts contributed to the movement of cancer cells away from the primary tumor, which resulted in their death. These anticancer effects weren't related to just one particular compound such as lycopene. Instead, the whole tomato seemed to contribute to its anticancer effects. Previous studies had suggested the carotenoid compound lycopene, which creates the orange-red color of tomatoes, is what fights cancer cells. While lycopene may still be a major factor, the entire tomato seemed to have a highly potent effect against cancer. Amino Acid Arginine Found As Effective As Drugs For Glucose Metabolism And DiabetesUniversity of Copenhagen & University of Cincinnati, October 9, 2022 If you suffer from type 2 diabetes, you may want to consider snacking on nuts to treat the condition. Supplementation with the amino acid arginine, commonly found in almonds and hazelnuts, could help to improve glucose metabolism by as much as 40%, according to new research in mice. The study shows that supplementation with the amino acid significantly improves glucose metabolism in both insulin-sensitive and insulin-resistant metabolisms. In new experiments, researchers from the University of Copenhagen working in collaboration with a research group at the University of Cincinnati, have demonstrated that the amino acid arginine, found in salmon, eggs, and nuts, improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice.

”In fact, the amino acid is just as effective as several well-established drugs for type 2 diabetics,” says postdoc Christoffer Clemmensen.  As improbable as it may seem, the most important molecule in regulating the function of our arteries is nitric oxide (NO), a gas better known to us as an air pollutant. As synthesized in our arteries in tiny quantities, however, NO acts as a powerful mediator of vasodilation, the mechanism by which arteries dilate, when necessary, to lower our blood pressure and increase the flow of blood to tissues that need it. The principal source of our NO is arginine. This occurs via enzyme-catalyzed reactions that occur in endothelial cells, the thin layer of smooth, tightly “tiled” cells that line the inner walls of our arteries. 

What researchers have found is that L-arginine potentiation of glucose-induced insulin secretion occurs independently of NO.

 The researchers found that arginine improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. “We can also see that arginine increases the body's production of glucagon-like peptide-1 (GLP-1), an intestinal hormone which plays an important role in regulating appetite and glucose metabolism, and which is therefore used in numerous drugs for treating type 2 diabetes,” said Clemmensen. Supplemental dosages of 6 to 8 grams L-Arginine per day are considered safe. Although available in food, for some applications such as stimulating secretion of growth hormone from the pituitary, it is not released quickly enough as the food is digested. The supplemental doses taken on an empty stomach will arrive at the blood-brain barrier without competition. Then growth hormone secretion will be stimulated which in turn can affect glucose metabolism Increasing green space could narrow lifespan gap between poorest and richest areas University of Glasgow (Scotland), October 19, 2022 Increasing the amount of natural (green and blue) space and private gardens has the potential to narrow the lifespan gap between those living in the most and least deprived areas, suggests research published online in the Journal of Epidemiology of Community Health. Each 10% increase in natural space is linked to a 7% fall in the incidence of early death among the under 65s, the findings indicate.  It's not clear if access to natural space might also be associated with differences in lifespan and protection against an earlier than expected death, so the researchers used the measure of “years of life lost,” or YLL for short, to try and find out. Natural space was defined as: woodland; scattered trees; scrub; marsh; heath; open water (inland or tidal); semi natural grassland; general natural areas, such as grass on sports pitches, roadside verges, and farmland; agriculture; hard bare ground, such as rocks, boulders, and cliffs; and soft bare ground, such as sand, soil, and foreshore. Areas with the highest income deprivation had the lowest average percentage cover of natural space and gardens (58.5%, 49–65%). People living in these areas had the highest levels of ill health. The study found that every 10% increase in natural space cover was associated with a 7% fall in the incidence of premature death.  Food for thought: Study finds link between depression and unhealthy diets Macquarie University, October 18, 2022 A Macquarie University study of 169 adults aged 17 to 35 found those eating a Western-style diet were more likely to have lower levels of kynurenic acid (KA)—a small molecule important to a number of bodily functions—and report higher levels of depression than those eating diets rich in fresh fruit and vegetables. Neuroscientist Dr. Edwin Lim and neuropsychologist Dr. Heather Francis published a paper on the findings of the study in the journal Frontiers in Nutrition. “Western-style diets high in fat, sugar and processed foods were already known to increase the risk of depression, but this is the first time a biological link involving the kynurenine pathway has been established,” Lim says. “People from the group eating an unhealthy diet had lower levels of KA and more severe symptoms of depression. This indicates that KA may help to protect us against depression.” The human body has a number of ways of producing important molecules and metabolites necessary to keep it functioning. One of these important molecules is tryptophan—an essential amino acid that the body can't make itself, that is found in foods like dairy products, poultry, bananas, oats, nuts and seeds. When tryptophan is broken down, it can produce either serotonin and melatonin—important for our mood and sleep—or it can be processed by the kynurenine pathway, which creates KA and other important metabolites linked to neurodegenerative diseases such as Alzheimer's disease. Lim says this is the first time anyone has been able to show that Western-style diet has an effect on the way that tryptophan is metabolized in otherwise healthy young people. “There is, however, a clear relationship between an increased risk of depression and eating an unhealthy diet that is high in fat, sugar and processed foods, giving us all the incentive to eat more fresh vegetables and fruit,” she says. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2022 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Patients who ate fish, vegetables and whole grains reported a greater reduction in symptoms than those on proton pump inhibitors (PPIs), the study found Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe.  In the study, published in the journal JAMA Otolaryngology – experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.'   Shorter sleep in later life linked to higher risk of multiple diseases University College London, October 19, 2022 Getting less than five hours of sleep in mid-to-late life could be linked to an increased risk of developing at least two chronic diseases, finds a new study led by UCL researchers. The research, published in PLOS Medicine, analyzed the impact of sleep duration on the health of more than 7,000 men and women at the ages of 50, 60 and 70, from the Whitehall II cohort study. Researchers examined the relationship between how long each participant slept for, mortality and whether they had been diagnosed with two or more chronic diseases(multimorbidity)—such as heart disease, cancer or diabetes—over the course of 25 years. People who reported getting five hours of sleep or less at age 50 were 20% more likely to have been diagnosed with a chronic disease and 40% more likely to be diagnosed with two or more chronic diseases over 25 years, compared to people who slept for up to seven hours. Additionally, sleeping for five hours or less at the age of 50, 60, and 70 was linked to a 30% to 40% increased risk of multimorbidity when compared with those who slept for up to seven hours. Researchers also found that sleep duration of five hours or less at age 50 was associated with 25% increased risk of mortality over the 25 years of follow-up—which can mainly be explained by the fact that short sleep duration increases the risk of chronic disease(s) that in turn increase the risk of death. “Our findings show that short sleep duration is also associated with multimorbidity. As part of the study, researchers also assessed whether sleeping for a long duration, of nine hours or more, affected health outcomes. There was no clear association between long sleep durations at age 50 and multimorbidity in healthy people. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2017 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe.  In the study, published in the journal JAMA Otolaryngology, experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.'

Ilham sits down with Nobel prize-winning scientists Professor Steven Chu and Professor Ben Feringa to discuss some of the most exciting innovations in energy, clean mobility, and healthcare; the importance of ensuring that scientific innovation is at the service of humanity; the winner of the 2022 Solvay prize; and how science and chemistry are key to enabling a more sustainable future.Steven Chu is a professor of Molecular and Cellular Physiology at Stanford University and the former US Secretary of Energy. In 1997, he was awarded the Nobel Prize in Physics for developing methods to cool and trap atoms with laser lights. Ben Feringa is a Professor at the University of Groningen, and the winner of the 2015 Solvay prize. In 2016, he won the Nobel Prize in Chemistry for his groundbreaking research on the design and synthesis of molecular machines. They are both part of the jury that chose the winner for the 2022 Solvay prize, Katalin Karikó. For additional details about the podcast, show notes, and access to resources mentioned during the show, please visit https://solvay.com/

I asked Michael Loewenstein on the podcast today to talk about his trailblazing presentation at AWT on Legionella Testing, and thankfully, he generously agreed to come on the podcast as my lab partner today. After listening to our cutting-edge conversation, I have a feeling you are going to want to learn more about the Cultural Method vs. the Rapid Method and submit Legionella samples to Michael for the next phase of his study so we've linked his contact information below. You know as well as I that when water treaters come together to share what we know, we can raise the bar for our entire industry, so I encourage everyone to further advance our industry by submitting samples as soon as they can. Buckle your seatbelts because this is going to be one groundbreaking conversation! For those of you who missed his presentation at AWT, Michael Loewenstein is the Vice President of Scientific Consulting at Q Labs LLC in Cincinnati, OH. He earned his B.S. in Microbiology, with a research focus in Molecular Genetics and Cellular Physiology from The Ohio State University. After graduation, Michael obtained a position in Corporate R&D Microbiology at Procter & Gamble where he focused on the development and validation of rapid/alternative microbial test methods and developed and launched preservative systems across a broad range of P&G products.   Throughout the course of his career, Michael has developed a substantial depth of expertise in “end-to-end” Microbiology - from product development and formulation through microbiological control of manufacturing, and he has published several articles on this subject. Michael worked as Site Microbiology Manager for a P&G drug manufacturing facility just prior to accepting the position with Q Labs in December 2018.   Michael currently serves in a volunteer capacity for several professional associations, including the AOAC Microbial Contaminants Expert Review Panel, and both the Microbiology Committee and Manufacturing Hygiene Task Force of the Personal Care Products Council (PCPC). Michael is also looking forward to becoming more involved with the Cooling Water subcommittee of AWT.    Bottom line: Michael Loewenstein is on the show to share the revolutionary results of his most recent scientific study on Legionella testing. Your roadside friend, as you travel from client to client.  -Trace    Timestamps:  Upcoming events [0:30] Thinking On Water With James: Are you stuck in a rut? [4:06] Getting to know Michael Loewenstein [6:15] Why the “Gold Standard” Method for Legionella testing isn't standardized  [8:50] The new/modern Rapid Method's capabilities [10:50] The Cultural Method vs. Rapid Method [11:40] Understanding Quantitative vs. Qualitative Legionella analysis [17:50] Potential pre-treatment problems with the Cultural Method [20:50] How COVID-19 increased public knowledge on PCR testing [ 23:08] What you need to know when switching from the Cultural Method to the Rapid Method [24:30] How to make a Hazard Strategy [29:00]  Advantages to the PCR Method [30:40] Lightning round questions [37:50]   Thinking On Water With James: Are you stuck in a rut? In this week's episode, we're thinking about being stuck in a rut. Are you stuck in a rut in your industrial water treatment career? Are you running the same old pinks and blues in the same accounts day after day? If so and you feel stuck in a rut, what are you missing by just going through the motions at each account? What other water parameters should you be testing? What other value-added projects are just waiting to be done that you currently cannot see while stuck in a rut? What equipment needs to be repaired or replaced? What new things can you learn? How can you take a fresh look at your accounts, testing habits, control equipment, daily routine, and knowledge base to mix things up a little and make you an even more valuable partner for your customers? If you feel stuck in a rut, take this next week to think about it and possibly reach out to someone else within your company and network to help get you out.   Quotes: “In reality, the “Gold Standard” of Legionella testing methods are not the same.” - Michael Loewenstein “Today, the Rapid Methods can distinguish live from dead cells, they are quantitative, and can characterize the Legionella to some degree.” - Michael Loewenstein “Modern technologies have found ways to discount the genetic materials from dead cells, so they now only count the genetic materials from live Legionella in the water sample.” - Michael Loewenstein “PCR is much more sensitive than the Cultural Method, so it puts the water treater in a proactive position rather than reactive.” - Michael Loewenstein “At low levels, the Cultural Method is highly variable and not particularly sensitive.” - Michael Loewenstein “Quantitative - how much Legionella is there? vs. Qualitative - is Legionella there or not?” - Michael Loewenstein “The limits for the Cultural Method are set semi-arbitrarily. There is nothing magic about less than 1 CFU/mL (1,000 CFU/L), except that it's what somebody picked.” - Michael Loewenstein “What would be great is more frequent testing and then set statistically-based action limits. Figure out for your system what is normal.” - Michael Loewenstein “PCR far out-performed the Cultural Method for Legionella testing.” - Michael Loewenstein   Michael Loewenstein's Presentation of Phase 1 of his method study presented at AWT: Technical Paper Presentation   Interested in submitting Legionella samples?  Please connect with Michael Loewenstein to help advance future studies Phone: (513) 207-4943 Email: MLoewenstein@qlaboratories.com Website: qlaboratories.com LinkedIn: in/michael-loewenstein-09693944   Links Mentioned: The Rising Tide Mastermind Submit a Show Idea Q Labs LLC Procter & Gamble AOAC INTERNATIONAL Personal Care Products Council (PCPC)  AWT (Association of Water Technologies) Centers For Disease Control And Prevention: Toolkit ISO 11731:2017 ASHRAE   Events:  National GroundWater Association's Hydrogeology of States Webinar Series: Vermont – February 9  AWT Technical Training Seminar - Feb 23-26 in Seattle, Washington AWT Technical Training Seminar  - March 30-April 2 in Cleveland, Ohio  

In this episode of GrowthSpurt, Bhavik Tadigotla speaks to UC San Diego PhD Student Amanda Wacker about her current research in bioengineering and molecular motors. In addition, Amanda provides some words of wisdom about navigating college and truly finding ones passions. This is a great episode, one filled with laughs and knowledge- you definitely don't want to miss out!

Our conversation with Dr. Brian Kobilka, recipient of the 2012 Nobel Prize in Chemistry for studies of G-protein-coupled receptors and Professor of Molecular and Cellular Physiology at Stanford University. Dr. Kobilka is a humble, passionate scientist who strongly believes in the importance of collaboration in science. Tune in to hear about his incredible story. See more about him and his work at https://med.stanford.edu/kobilkalab.html.

SHR # 2694:: Antihypertensive Properties of Green and Black Tea - Dr. Geoffrey W. Abbott, M.S., Ph.D. - A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Published in Cellular Physiology and Biochemistry, the discovery was made by the laboratory of Geoffrey Abbott, PhD, a professor in the Department of Physiology and Biophysics at the UCI School of Medicine. Kaitlyn Redford, a graduate student in the Abbott Lab, was first author of the study titled, "KCNQ5 potassium channel activation underlies vasodilation by tea." Results from the research revealed that two catechin-type flavonoid compounds (epicatechin gallate and epigallocatechin-3-gallate) found in tea, each activate a specific type of ion channel protein named KCNQ5, which allows potassium ions to diffuse out of cells to reduce cellular excitability. As KCNQ5 is found in the smooth muscle that lines blood vessels, its activation by tea catechins was also predicted to relax blood vessels - a prediction confirmed by collaborators at the University of Copenhagen.

SHR # 2694:: Antihypertensive Properties of Green and Black Tea - Dr. Geoffrey W. Abbott, M.S., Ph.D. - A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Published in Cellular Physiology and Biochemistry, the discovery was made by the laboratory of Geoffrey Abbott, PhD, a professor in the Department of Physiology and Biophysics at the UCI School of Medicine. Kaitlyn Redford, a graduate student in the Abbott Lab, was first author of the study titled, "KCNQ5 potassium channel activation underlies vasodilation by tea." Results from the research revealed that two catechin-type flavonoid compounds (epicatechin gallate and epigallocatechin-3-gallate) found in tea, each activate a specific type of ion channel protein named KCNQ5, which allows potassium ions to diffuse out of cells to reduce cellular excitability. As KCNQ5 is found in the smooth muscle that lines blood vessels, its activation by tea catechins was also predicted to relax blood vessels - a prediction confirmed by collaborators at the University of Copenhagen.

The Howard Hughes Medical Institute is adding a new research focus -- 4D Cellular Physiology. On this episode of the Pathways Podcast from the American Society for Cell Biology we chat with Ron Vale, the Vice President and Executive Director of HHMI's Janelia Research Campus, and Jennifer Lippincott-Schwartz, a senior group leader also at Janelia, about this new direction and how it will impact the cell biology community. --- Send in a voice message: https://anchor.fm/ascb-pathwayspodcast/message

This week, we welcome Steven Chu, Professor of Physics and Physiology at Stanford University, and the 1997 co-recipient of the 1997 Nobel Prize in Physics to Cleaning Up. Professor Chu was was the first of two Secretaries of Energy during President’s Obama term as president, the second being Ernie Moniz, my guest on Episode 17 of Cleaning Up. He is now the Chair of the Board of the American Association of the Advancement of Science (AAAS). Bio Professor Steven Chu is currently William R. Kenan, Jr., Professor of Physics and Professor of Molecular and Cellular Physiology at Stanford University. He is also the Chair of the Board of the American Association for the Advancement of Science, a non-profit organisation defending scientific freedom and encouraging a collaborative approach in order to serve humanity as a whole. Professor Steven Chu served as Secretary of Energy under President Barack Obama from January 2009 through to April 2013. Before that, he was leading the Lawrence Berkley National Laboratory as well as being professor of Molecular and Cell Biology, from 2004 to 2009, at UC Berkeley. Prior to this, he was the Francis and Theodore Geballe Professor of Physics and Applied Physics at Stanford University for 22 years starting in 1987. During this period, Chu was a co-recipient of the 1997 Nobel Prize in Physics for his ground-breaking work in laser cooling and atom trapping Professor Steven Chu is a member of the National Academy of Sciences, the American Philosophical Society, and the American Academy of Arts Sciences, and a winner of the Humboldt Prize. Professor Chu earned his BA and BSc from the University of Rochester before receiving his Ph.D. in physics from the University of California, Berkeley. Professor Chu has also received over 30 honorary degrees. Links Official bio https://physics.stanford.edu/people/steven-chu US Government Biography https://www.energy.gov/contributors/dr-steven-chu AAAS https://www.aaas.org/ Nobel Prize https://www.nobelprize.org/prizes/physics/1997/chu/facts/ National Academy of Sciences http://www.nasonline.org/ The American Philosophical Society https://www.amphilsoc.org/ SunShot Initiative https://www.energy.gov/eere/solar/sunshot-initiative Lawrence Berkeley National Laboratory https://www.lbl.gov/ Ex-Energy Secretary Says Fixing Climate Change Is Tough, There's No Vaccine (December 2020) https://www.wxxinews.org/post/ex-energy-secretary-says-fixing-climate-change-tough-theres-no-vaccine Steven Chu Compares Energy Department Loan Program To An Unsedated Colonoscopy (June 2020) https://www.forbes.com/sites/jeffmcmahon/2020/06/25/steven-chu-compares-energy-department-loans-to-a-colonoscopy/?sh=14e082ae76e1 Steven Chu: Long-Term Energy Storage Solution Has Been Here All Along (June 2020) https://www.forbes.com/sites/jeffmcmahon/2020/06/24/steven-chu-long-term-energy-storage-solution-has-been-here-all-along/?sh=144159056607 About Cleaning Up: Once a week Michael Liebreich has a conversation (and a drink) with a leader in clean energy, mobility, climate finance or sustainable development. Each episode covers the technical ground on some aspect of the low-carbon transition – but it also delves into the nature of leadership in the climate transition: whether to be optimistic or pessimistic; how to communicate in order to inspire change; personal credos; and so on. And it should be fun – most of the guests are Michael’s friends. Follow Cleaning Up on Twitter: https://twitter.com/MLCleaningUp​​ Follow Cleaning Up on Linkedin: https://www.linkedin.com/company/clea...​ Follow Cleaning Up on Facebook: https://www.facebook.com/MLCleaningUp​​ Links to other Podcast Platforms: https://www.cleaningup.live​​ 

Do you enjoy my podcast? If so consider donating here: Donate Join our community of culture builders here. +++++++++++++++++++++++++++++++++++++++++++++ There are few topics that hit emotional buttons as vaccinations. The internet is awash with pro-vaccines vs anti-vaccines arguments. And if you add in the whole CCP Virus as a background, you have a perfect storm of controversy.  This week’s guest is Dr. Theresa Deisher, who holds a doctorate in Molecular and Cellular Physiology from Stanford University School of Medicine. She is the founder and lead scientist at Sound Choice Pharmaceutical Institute, and the CEO of AVM Biotechnology. Dr. Deisher holds more than 47 issued US/EU/Japan patents and four discoveries in clinical trials and has over 30 years of pharmaceutical leadership experience including Genentech, Repligen, ZymoGenetics, Immunex, and Amgen. Read the rest here:  https://www.patrickcoffin.media/the-coming-covid-19-vaccine/ 

In this episode of the ORS podcast Johnny and the fellas discuss a recent paper that has given additional support to the ability of repeated inflations of a cuff limiting muscle atrophy from disuse. Here's the paper: Kakehi, S., Tamura, Y., Kubota, A., Takeno, K., Kawaguchi, M., Sakuraba, K., Kawamori, R., & Watada, H. (2020). Effects of blood flow restriction on muscle size and gene expression in muscle during immobilization: A pilot study. Physiological Reports, 8(14), e14516. Other papers referenced: Du Bois, P., Pablo Tortola, C., Lodka, D., Kny, M., Schmidt, F., Song, K., Schmidt, S., Bassel-Duby, R., Olson, E. N., & Fielitz, J. (2015). Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression. Circulation Research, 117(5), 424–436. Joshi, S., Wollenzien, H., Leclerc, E., & Jarajapu, Y. P. (2019). Hypoxic regulation of angiotensin-converting enzyme 2 and Mas receptor in human CD34+ cells. Journal of Cellular Physiology, 234(11), 20420–20431. Tipton, K. D., Hamilton, D. L., & Gallagher, I. J. (2018). Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans. Sports Medicine , 48(Suppl 1), 53–64. Kubota, A., Sakuraba, K., Koh, S., Ogura, Y., & Tamura, Y. (2011). Blood flow restriction by low compressive force prevents disuse muscular weakness. Journal of Science and Medicine in Sport / Sports Medicine Australia, 14(2), 95–99. Kubota, A., Sakuraba, K., Sawaki, K., Sumide, T., & Tamura, Y. (2008). Prevention of disuse muscular weakness by restriction of blood flow. Medicine and Science in Sports and Exercise, 40(3), 529–534. What everyone wanted though…the squirrel story!! https://www.sciencemag.org/news/2019/10/here-s-how-hibernating-squirrels-live-months-without-water Credit to FoolBoyMedia on free sound.org for the sound byte: https://freesound.org/s/504687/

Guest: Theresa Deisher, PhD. Dr. Theresa Deisher’s career has focused on discovering and developing new therapies for grievous human illness. Dr. Deisher obtained her Ph.D. in Molecular and Cellular Physiology from Stanford University and has spent over 30 years in commercial biotechnology. Prior to founding AVM Biotechnology and Sound Choice Pharmaceutical Institute (SCPI), she worked with leading biotechnology companies, including Genentech, Repligen, ZymoGenetics, Immunex, and Amgen. AVM Biotechnology does not use morally illicit material in any process and develops products that improve outcomes without additional suffering, because side effects from treatments of cancers or infections should never be worse than the diseases themselves. SCPI’s mission is to end human trafficking in biomedical research. Dr. Deisher is an inventor on 47 issued US/EU/Japan patents and 3 discoveries in clinical trials. She was the first to discover adult cardiac derived stem cells and has been a champion of adult stem cell research.

Guest: Theresa Deisher, PhD. Dr. Theresa Deisher’s career has focused on discovering and developing new therapies for grievous human illness. Dr. Deisher obtained her Ph.D. in Molecular and Cellular Physiology from Stanford University and has spent over 30 years in commercial biotechnology. Prior to founding AVM Biotechnology and Sound Choice Pharmaceutical Institute (SCPI), she worked with leading biotechnology companies, including Genentech, Repligen, ZymoGenetics, Immunex, and Amgen. AVM Biotechnology does not use morally illicit material in any process and develops products that improve outcomes without additional suffering, because side effects from treatments of cancers or infections should never be worse than the diseases themselves. SCPI’s mission is to end human trafficking in biomedical research. Dr. Deisher is an inventor on 47 issued US/EU/Japan patents and 3 discoveries in clinical trials. She was the first to discover adult cardiac derived stem cells and has been a champion of adult stem cell research.

Learn about why people can’t help but “shoot the messenger;” how neurons in your gut influence neurons in your brain thanks to the gut-brain axis; and why we still use the QWERTY keyboard, along with information on Dvorak and Colemak layouts. People can't help but "shoot the messenger" by Kelsey Donk We Really Do Shoot the Messengers of Bad News, Research Suggests. (2019, April 16). Harvard Business Review. https://hbr.org/2019/04/research-confirms-when-receiving-bad-news-we-shoot-the-messenger  John, L. K., Blunden, H., & Liu, H. (2019). Shooting the messenger. Journal of Experimental Psychology: General, 148(4), 644–666. https://doi.org/10.1037/xge0000586  Neurons in your gut influence neurons in your brain by Andrea Michelson Gut communicates with the entire brain through cross-talking neurons. (2020). EurekAlert! https://www.eurekalert.org/pub_releases/2020-04/uoic-gcw040220.php  Parker, C. G., Dailey, M. J., Phillips, H., & Davis, E. A. (2020). Central sensory-motor crosstalk in the neural gut-brain axis. Autonomic Neuroscience, 225, 102656. https://doi.org/10.1016/j.autneu.2020.102656  The Brain-Gut Connection. (2020). https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-brain-gut-connection  Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K., O’Connor, G., Grati, M., Mittal, J., Yan, D., Eshraghi, A. A., Deo, S. K., Daunert, S., & Liu, X. Z. (2017). Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis. Journal of Cellular Physiology, 232(9), 2359–2372. https://doi.org/10.1002/jcp.25518  Hadhazy, A. (2010, February 12). Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being. Scientific American. https://www.scientificamerican.com/article/gut-second-brain/  Here's Why We Still Use the QWERTY Keyboard by Trevor English Liebowitz, S. J., & Margolis, S. (1996, June). Typing Errors. Reason.com; Reason. https://reason.com/1996/06/01/typing-errors/  ‌Yasuoka, K., & Yasuoka, M. (2011). On the Prehistory of QWERTY. ZINBUN, 42, 161–174. https://doi.org/0084-5515  Hoffman, C. (2014, May 18). Alternative Keyboard Layouts Explained: Should You Switch to Dvorak or Colemak? How-To Geek; How-To Geek. https://www.howtogeek.com/189270/alternative-keyboard-layouts-explained-dvorak-colemak-and-whether-you-should-care/  Subscribe to Curiosity Daily to learn something new every day with Cody Gough and Ashley Hamer. You can also listen to our podcast as part of your Alexa Flash Briefing; Amazon smart speakers users, click/tap “enable” here: https://www.amazon.com/Curiosity-com-Curiosity-Daily-from/dp/B07CP17DJY

Must Listen! The President of the American Association for the Advancement of Science, former US Secretary of Energy, Nobel Prize Winning Physicist, Professor of Molecular & Cellular Physiology at Stanford University – Now in Agreement with What BOB Has Been Saying for Years about Climate Change! + Must Continue Listening! Extraordinary, Far – Ranging Discussion with […]

In this episode, I speak with Lise Eliot — Professor of Neuroscience at The Chicago Medical School of Rosalind Franklin University, and the author of ‘Pink Brain, Blue Brain: How Small Differences Grow into Troublesome Gaps and What We Can Do About It.’ In this interview, I tried to get to the root of what informs gender identity and its relationship to our biology, specifically regarding human neurology and brain development. The questions we explore in this episode include: What significant neurological differences exist between a “male” and “female” brain, especially at the time of birth? If differences exist, what role do these differences play in the development of individual traits -- traits that may be categorized culturally as either “female” or “male” in nature? How much is the development of an individual's gender identity associated with cultural, rather than biological, factors? Along with these subject, we also delve into questions regarding transgender and childhood gender identity. Dr. Eliot's research and insight sheds a light on the complex interplay between biology, childhood brain development, and cultural practices on gender identity and its connection, or lack thereof, to biological sex. Dr. Eliot’s research is centered on brain and gender development, especially the role of neuroplasticity in shaping neural circuitry and behavior. Her studies range from cellular neurophysiology to meta-analyses of brain sex difference and include two highly-praised trade books, ‘What's Going On in There? How the Brain and Mind Develop in the First Five Years of Life,’ and ‘Pink Brain, Blue Brain: How Small Differences Grow Into Troublesome Gaps.’ Through both empirical and scholarly research, Dr. Eliot analyzes the interplay between innate biology, sociocultural factors, and individual experience in molding our brains and behavior across the lifespan. She received an A.B. degree magna cum laude in History & Science from Harvard University, a Ph.D. in Cellular Physiology & Biophysics from Columbia University, and completed a post-doctoral fellowship in the Division of Neuroscience at Baylor College of Medicine. ⚧ ⚧ Source: http://bit.ly/LiseEliot Episode Notes: - Learn more about Lise an her work at her website: http://www.liseeliot.com - Learn more and purchase her book ‘Pink Brain, Blue Brain’ here: http://bit.ly/PinkBrainBlue - Follow Lise on Twitter: https://twitter.com/Lise_Eliot - What sparked my interest in Lise’s work was an article in The Atlantic titled ’Are Male and Female Brains Biologically Different?’ Read the piece here: http://bit.ly/2AAIGNt - Watch and listen to Lise’s discuss her work at the 2018 Aspen Ideas Festival: https://youtu.be/lyfheYxPPL0 - The song featured in this episode is “Tired Boy” by Joey Pecoraro from the album Tired Boy. - WEBSITE: https://www.lastborninthewilderness.com - SUPPORT THIS PROJECT: Patreon: http://bit.ly/LBWPATREON Donation: http://bit.ly/LBWKOFI - FOLLOW & LISTEN: SoundCloud: http://bit.ly/LBWSOUNDCLOUD iTunes: http://bit.ly/LBWITUNES Google Play: http://bit.ly/LBWGOOGLE Stitcher: http://bit.ly/LBWSTITCHER RadioPublic: http://bit.ly/LBWRADIOPUB YouTube: http://bit.ly/LBWYOUTUBE - SOCIAL MEDIA: Facebook: http://bit.ly/LBWFACEBOOK Twitter: http://bit.ly/LBWTWITTER Instagram: http://bit.ly/LBWINSTA

We are visual beings, and qualities such as “insight” and “vision” describe our understanding well beyond sensory input. Light and more generally, electromagnetic radiation, has dramatically changed our knowledge of the physical world. It is also the source of the oxygen we breathe, the food we eat, and the energy that has powered the world since the beginning of the industrial revolution. Nobel Laureate Steven Chu, Professor of Physics, Professor Molecular & Cellular Physiology, Stanford University, discusses how light will continue to expand our scientific horizons and redefine our daily lives: from the measurement of time, to biology, medicine, and combating climate change. Series: "Scientific Horizons" [Science] [Show ID: 30224]

We are visual beings, and qualities such as “insight” and “vision” describe our understanding well beyond sensory input. Light and more generally, electromagnetic radiation, has dramatically changed our knowledge of the physical world. It is also the source of the oxygen we breathe, the food we eat, and the energy that has powered the world since the beginning of the industrial revolution. Nobel Laureate Steven Chu, Professor of Physics, Professor Molecular & Cellular Physiology, Stanford University, discusses how light will continue to expand our scientific horizons and redefine our daily lives: from the measurement of time, to biology, medicine, and combating climate change. Series: "Scientific Horizons" [Science] [Show ID: 30224]

Immunologist Sarah Schlesinger must try to save her mentor's life with his own work in cellular immunity. Sarah J. Schlesinger MD is a clinical investigator and immunologist at The Rockefeller University who has spent more than 20 years working in the field of cellular immunity, including as clinical director of the laboratory led by the late Ralph M. Steinman, M.D., 2011 Nobel Laureate in Physiology or Medicine. She is currently Senior Attending Physician and Associate Professor of Clinical Investigation at the Laboratory of Cellular Physiology and Immunology at Rockefeller. Prior to joining the University, Dr. Schlesinger was a scientist at the International AIDS Vaccine Initiative in New York City. From 1996 to 2002, Dr. Schlesinger was a Research Physician/Pathologist at the Division of Retrovirology at Walter Reed Army Institute of Research, having previously served, from 1994 to 2002, as Staff Pathologist at the Armed Force Institute of Pathology in Washington, DC. Dr. Schlesinger trained in Surgery at the Albert Einstein College of Medicine and began her career in pathology at Georgetown University in Washington, DC, and hospitals in New York including Buffalo General, Hospital New York and the Manhattan Eye, Ear and Throat Hospital. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Ege Kavalali is a Professor in the Departments of Physiology and Neuroscience at The University of Texas Southwestern Medical Center. He is also the Effie Marie Cain Scholar in Medical Research and the Rosewood Corporation Chair in Biomedical Science. He received his PhD in Biomedical Engineering from Rutgers University and then completed a postdoctoral fellowship at Stanford University in the department of Molecular and Cellular Physiology. Ege is with us today to tell us about his journey through life and science.