POPULARITY
17 episodes with Synovial
4 episodes with Synovial
4 episodes with Synovial
2 episodes with Synovial
2 episodes with Synovial
2 episodes with Synovial
2 episodes with Synovial
2 episodes with Synovial
Synovial joints are specialised for movement. The shapes of the articulating surfaces define what movements are allowed, and we can anatomically classify synovial joints by these shapes and by these movements. We have hinge, ball and socket, plane, saddle and condyloid synovial joints.
In this episode of Curiosity Killed the Plaque, Spring Hatfield, RDH, BSPH, looks at synovial chondromatosis of the TMJ, a rare, mostly benign, aggressive metaplastic change in the synovial membrane.Like this show? Leave us a review on your favorite podcasting app!Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Celia: I suffer from severe anxiety specifically around driving, being a passenger in a car, crowded places, big stores etc. It all came on all of a sudden and has been around for the last 4 years or so. I also have PCOS and believe I am in perimenopause BUT going to the doctor is a trigger as well. It's even worse in the summer heat. My current hair analysis is on the way to the lab. I have taken 2 before but the practitioner said I needed around 25 different supplements. Money was rolling out the door with no change. What main vitamins do you suggest for someone with PCOS, perimenopause and extreme anxiety? I currently take fulvic, black seed oil, omega 3, vit d3/k2, inositol and magnesium glycinate. Thank you, Celia Anonymous: I am a natural health practitioner and a very heavy drinker. Talk about feeling like a fraud...Started ~10 yrs ago and gradually increased to 1-2 bottles wine/prosecco or several gin+tonics, bloody marys, etc almost every day for the past five years. It started as a coping mechanism when triggered for past traumas, but then became a habit, and I'm working with a therapist now on the emotional and mind aspects. I need help with the physical. By the time you read this, I am hopeful I will have been sober for 8 weeks. If you were in my shoes, what steps and how long before you would do a FM detox? How else to heal all of the physical trauma placed on not just the liver, but the brain, heart...all of it? Thank you so much for your care in addressing what is often a taboo subject. Nicholas: Hi Dr Cabral. I need your help! I have synovial chondromatosis in my knee. I have had 2 surgeries within the last 2 years to remove the tumours, however they couldn't remove them all and they are growing back. I live a healthy active lifestyle (gym 3-4 x week, tennis 1 x week, walk dog 7 x week), eat organic when I can, take supps (are glutamine, creatine, collagen, whey protein, Antiaging supp with NR/NMN/resveratrol a problem?) I sauna/cold plunge 2-3 x week. I have recently done your detox. What could be the potential root cause/imbalance? What would you recommend I do (testing, supps, lifestyle) to address my condition? Sheena: Hi Dr C. Hope you and your team are well. I'm a 46 yo female, 111 lbs, 5 feet w/ a BMI of 21. I'm feeling really overwhelmed and confused as to how to get and stay in shape lately. I'm pretty knowledgeable in the health and fitness world and am pretty healthy but now that Im in perimenopause, I cant tell what's causing what? I've actually gained weight but idk if its becuz I'm in perimenopause? where do I start to stay healthy inside and outside. Im an vata w/ a little kaffa and don't know how to work out for my body anymore. I feel catabolic but at times I feel I can gain weight so easily on my legs. Just so confused at this time in my life as to how to stay healthy because I feel so much is changing hormonally and I cant seem to grasp control or understand what's happening. Help! Jenny: Hi Dr. Cabral, Now that you/EquiLife are unable to provide CBD gummies and your other CBD products, is there a brand you recommend or use personally? Thanks for all you do! Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3704 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Dr. James Kirk of Odessa, Texas specializes in treating the most difficult spine related conditions and shares the story of a gentleman facing spine surgery with a synovial cyst causing foot drop. Dr. J W Kirk is the owner and CEO of Clark Chiropractic Clinic, P.C. He was born in Odessa, he graduated from Parker College of Chiropractic in 1992 with a Bachelor of Science in Human Anatomy and a Doctorate in Chiropractic. His undergraduate studies were at North Harris County College and Texas Tech University. He has been a Rotarian since 1992 and serves on their board. He is a board member of the Odessa Fire Fighters Pension Fund. He is an Elder at Odessa Bible Church. He is a Certified Cox flexion/distraction practitioner. He and each doctor practice with a 'Low Force' technique called Directional Non-force Technique or DNFT. Dr. Kirk's website 1-432-337-5553 Find a Back Doctor The Cox 8 Table made by Haven Medical
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Synovial Sarcoma from our Pathology at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Last year at the 2025 AAHKS Annual Meeting, our host William B. Kurtz, MD spoke with the James A. Rand, MD, Young Investigator’s Award recipient Michael E. Neufeld, MD, MSc, FRCSC about his study on Synovial Metal Ions in “Nickel Free” vs. Standard Cobalt-Chrome Containing Total Knee Replacement. Dr. Neufeld shared that the aim of his study was to compare intraarticular synovial fluid levels of metal ions in patients who underwent cemented primary TKA with a hypoallergenic implant vs. a matched cohort of standard cobalt-chromium (Co-Cr) containing implants at a minimum two-year follow-up. A case-controlled study was conducted using prospectively collected data from a single institution – 22 cases and 19 controls. Interestingly, the study uncovered that patients with hypoallergenic implants had intraarticular synovial Ni ion levels 3.6 times higher vs. standard implant controls, contesting the use of this hypoallergenic implant for Ni allergy/hypersensitivity. Listen to the full discussion and make sure you click subscribe! Thanks for listening to AAHKS Amplified! In This Episode: William B. Kurtz, MD Michael E. Neufeld, MD, MSc, FRCSC The post Synovial Metal Ions in Nickel Free vs. Standard Cobalt-Chrome Containing Total Knee Replacement first appeared on AAHKS.
Last year at the 2025 AAHKS Annual Meeting, our host William B. Kurtz, MD spoke with the James A. Rand, MD, Young Investigator’s Award recipient Michael E. Neufeld, MD, MSc, FRCSC about his study on Synovial Metal Ions in “Nickel Free” vs. Standard Cobalt-Chrome Containing Total Knee Replacement. Dr. Neufeld shared that the aim of his study was to compare intraarticular synovial fluid levels of metal ions in patients who underwent cemented primary TKA with a hypoallergenic implant vs. a matched cohort of standard cobalt-chromium (Co-Cr) containing implants at a minimum two-year follow-up. A case-controlled study was conducted using prospectively collected data from a single institution – 22 cases and 19 controls. Interestingly, the study uncovered that patients with hypoallergenic implants had intraarticular synovial Ni ion levels 3.6 times higher vs. standard implant controls, contesting the use of this hypoallergenic implant for Ni allergy/hypersensitivity. Listen to the full discussion and make sure you click subscribe! Thanks for listening to AAHKS Amplified! In This Episode: William B. Kurtz, MD Michael E. Neufeld, MD, MSc, FRCSC The post Synovial Metal Ions in Nickel Free vs. Standard Cobalt-Chrome Containing Total Knee Replacement first appeared on AAHKS.
In this episode, Antonia and Andrew discuss the November 19, 2025 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you by JBJS Clinical Classroom. Subspecialties: Infection, Orthopaedic Essentials, Trauma, Hip, Knee Chapters (00:00:03) - Your Cases On Hold(00:00:45) - JBJS 10/20/20(00:03:54) - MPO ELISA test for chronic myeloperoxidase(00:11:29) - Chemical Disinfection of Accidental Infections during Orthoped(00:19:06) - Delayed Union and Nonunion Rates and Open Fractures(00:23:45) - Legacy of Open Fracture in the US(00:29:46) - How to prevent 3A in 3A patients(00:30:39) - DARE for early hip, knee infection(00:32:29) - Synovial fluid Mirnas: potential biomarkers in hip and(00:34:09) - Journals Review: The New Issue
Tom opens this week's livestream with a recap of the 2025 Wise Traditions Conference, sharing highlights and reflections from the weekend. He discusses key presentations, themes, and insights.Highlights include:-Meaningful moments connecting with Sam and Mark Bailey, Andy Kaufman, and others-What makes the Weston A. Price Conference so unique—and why it matters-The “cult of the bouncing billiard balls” and how 20th-century science went off course-How real health discussions begin after we stop asking the wrong questions (like “what causes chickenpox?”)-Questions we should be asking about sickness, child-rearing, and social structures-Tom's take on government, mandatory schooling, and democracy-How we might begin to form truly life-supporting communitiesTom answers questions from the audience in a live Q&A session, topics include:-What is light?-Is radon in the basement dangerous?-Using magnets for healing-Mold exposure and detox support-Synovial cysts and natural approaches-Hyperbaric oxygen therapy: helpful or harmful?-Analemma wand vs. water filtration-Elderly UTIs and detox-Does Tom drink coffee?Support the showWebsites:https://drtomcowan.com/https://www.drcowansgarden.com/https://newbiologyclinic.com/https://newbiologycurriculum.com/Instagram: @TalkinTurkeywithTomFacebook: https://www.facebook.com/DrTomCowan/Bitchute: https://www.bitchute.com/channel/CivTSuEjw6Qp/YouTube: https://www.youtube.com/channel/UCzxdc2o0Q_XZIPwo07XCrNg
Modern joint pain isn't just wear and tear—it's a systemic, metabolic disease that starts years before symptoms show. In this episode, you'll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He's the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He's a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results. He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You'll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration. You'll learn: • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog • How cartilage begins to break down in your teens—and what to do about it now • The surprising clinical data on walking distance, inflammation markers, and recovery • Why most supplements and NSAIDs fail—and what actually rebuilds joints • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal • The mitochondrial link between joint pain, cardiovascular risk, and depression • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it • How to track your biological joint age using imaging and systemic inflammation labs This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you're lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave ** Thank you to our sponsors! -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 2:01 — Why Modern Medicine Fails at Joint Pain 3:07 — Painkillers That Accelerate Joint Damage 7:35 — Rheumatoid vs. Osteoarthritis Explained 8:54 — Cytokines That Destroy Cartilage 12:10 — Arthritis Begins in Your Teens 15:35 — 75% Pain Reduction in 7 Days 18:35 — The Science Behind Boswellia & Celery Seed 24:10 — Six-Minute Walk Test Results 25:45 — The $200/Month Painkiller Trap 28:53 — Proof Cartilage Can Regrow 31:01 — Mitochondria and Joint Repair 32:29 — Inflammation Links to Heart Disease 35:52 — Why Glucosamine Doesn't Work 37:07 — Silent Arthritis in 90% of Adults 40:44 — Why Women Face Higher Joint Risk After 40 45:52 — Food as the #1 Inflammation Trigger 47:23 — Fasting & Cartogenics Stack for Repair 50:27 — Movement Snacks and Efficient Training 55:54 — Why Joints Heal Slower Than Muscles 57:48 — Dave's Stack and Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Synovial Facet Cyst of Spine from the Spine section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Synovial Sarcoma from the Pathology section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Plant-Based Fitness & Strength Training with Robert Cheeke Watch it on YoutTube HERE Read the Blog HERE Episode Overview Join Maxime Sigouin, founder of Fit Vegan Coaching, as he interviews plant-based fitness pioneer Robert Cheeke about resistance training, longevity, and building muscle on a plant-based diet. With 30 years of plant-based living and decades of strength training experience, Robert shares invaluable insights on training evolution, injury prevention, and the mindset shifts needed for sustainable fitness. Key Topics Covered Training Evolution & Mindset (00:01:50 - 00:15:00) How training approaches change from your 20s to 40s and beyond Shifting from performance-focused to longevity-focused training The importance of acceptance and removing comparison pressure Finding joy in movement vs. training as a burden The Power of Consistent Movement (00:15:00 - 00:20:00) Choosing movement first: always taking stairs, walking meetings Non-exercise activity benefits for mental clarity and creativity Making conscious choices to incorporate movement throughout the day Strength Training Benefits (00:24:00 - 00:35:00) Building skeletal muscle and bone density Preventing sarcopenia (age-related muscle loss) Enhancing mood and building character Creating an efficient fat-burning metabolism Functional benefits for all sports and activities Debunking Fitness Myths (00:29:00 - 00:45:00) Why fear of "getting too bulky" is unrealistic The illusion component of looking fit (body fat % matters more than size) Cardio vs. strength training for fat loss Why you can't outwork a bad diet Workout Structure & Injury Prevention (00:45:00 - 01:10:00) Warm-up: Why cold muscles are injury-prone Dynamic vs. static stretching RPE (Rate of Perceived Exertion) under 5 Synovial fluid and joint lubrication Main Workout: Progressive loading strategies Form over ego lifting Self-awareness and accepting being a beginner Common injury patterns and prevention Cool-down: Reducing DOMS (Delayed Onset Muscle Soreness) Maintaining range of motion The connection between stretching and posture Keys to Long-term Success (01:10:00 - 01:15:00) Creating structure and systems Building identity through consistent actions Connecting today's actions to future outcomes Finding motivation through results, not just willpower Notable Quotes "Consistency is possibly the most important word in the world after love" "The fear of getting too muscular is like the fear of accidentally becoming a billionaire" "You can't fail if you don't quit" Action Items for Listeners Start with 3x/week, 30-minute strength training sessions Always warm up properly - never rush this phase Focus on form over weight lifted Include 5 minutes of post-workout stretching Track workouts to create accountability Remove comparison to others - train for your own goals Resources Mentioned Maxime Sigouin's YouTube channel - 100+ exercise form videos Books by Robert Cheeke: "The Plant-Based Athlete" "The Impactful Vegan" Fit Vegan Coaching program Key Takeaways Strength training is essential for longevity, bone density, and quality of life at any age. Success comes from consistency, proper form, and training for your own goals rather than comparing yourself to others. The journey from performance-focused to longevity-focused training requires mindset shifts but ultimately leads to more sustainable, enjoyable fitness practices.
Synovial chondromatosis is a benign process that results in the formation of numerous loose bodies within a joint. This can lead to significant functional limitations as well as pain. In this episode, we discuss its pathogenesis, diagnosis and management options. Habusta SF, Mabrouk A, Tuck JA. Synovial Chondromatosis. 2023 Apr 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29262110 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/
Clinician-researcher Daniel Lefler, MD, reviews Afami-cel, the first FDA-approved immunotherapy designed to treat synovial cancer, a rare, aggressive soft-tissue malignancy.
Welcome to Season 2 of the Orthobullets Podcast. Today's show is Core, where we review Core Knowledge for Orthopaedic Surgeons. This episode will cover the topic of Synovial Sarcoma, from our Pathology section at Orthobullets.com. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube
FDA Drug Information Soundcast in Clinical Oncology (D.I.S.C.O.)
Listen to a soundcast of the 8.2.2024 FDA approval of Tecelra (afamitresgene autoleucel) for unresectable or metastatic synovial sarcoma.
Welcome to the Orthobullets Podcasts. Today's show is Total Recall, where we review all of the highest yield points for anyone studying for the Orthopedic in Training Exam or part one of the ABOS Board Exam. Today's episode will cover the topic of Synovial Sarcoma from the Pathology section at Orthobullets.com. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube
This week Jonathan is joined by Isabelle Amigues, CEO and Founder of UnabridgedMD, Denver, Colorado, USA. Together, they discuss the first part of her career as an academic clinician followed by how her diagnosis of Stage IV breast cancer shaped her approach to use the best in data-driven Western medicine combined with traditional Eastern healing. Timestamps: (00:00) - Introduction (02:02) - Isabelle's unique hobby: rock climbing (03:33) - Isabelle's journey into rheumatology (05:58) - Being diagnosed with Stage IV breast cancer (14:17) - The mind-body connection (20:25) - “Hope driven by science” (24:25) - The benefits of holistic approaches (32:29) - Psychological distress in healthcare professionals (37:10) - Synovial fluid and biomarker proteins (39:48) - Isabelle's three wishes for healthcare (42:37) - Outro
Dr Warner discusses the FDA approval of afami-cel for patients with advanced synovial sarcoma and key findings from the pivotal SPEARHEAD-1 trial.
In a conversation with CancerNetwork®, Brian A. Van Tine, MD, PhD, spoke about the FDA accelerated approval of afamitresgene autoleucel (afami-cel; Tecelra) for patients with metastatic or unresectable synovial sarcoma expressing MAGE-A4. He discussed the data from the phase 2 SPEARHEAD-1 trial (NCT04044768) supporting the agent's use in this patient population and highlighted how this approval might pave the way for other potential developments in the sarcoma landscape. Van Tine, a professor of medicine and pediatrics and a medical oncologist at Siteman Cancer Center of Washington University in St. Louis, detailed results from SPEARHEAD-1 leading to the FDA's approval of afami-cel. Based on these findings and the agent's potential availability as a one-time intravenous fusion, afami-cel may offer improvements in quality of life to patients with synovial sarcoma compared with standard treatment options such as chemotherapy. Topline data from cohort 1 of the SPEARHEAD-1 trial showed that treatment with afami-cel produced an objective response rate of 43% among 44 evaluable patients, which included a complete response rate of 4.5%. Additionally, the median duration of response was 6 months (95% CI, 4.6-not reached). Of patients with a response, durable responses lasting for 12 months or longer occurred in 39%. In terms of other potential benefits following the accelerated approval of afami-cel, Van Tine said that the T-cell therapy may increase treatment access to specific subsets of patients. For those who are unable to relocate and live near certain treatment centers during their therapy, afami-cel may offer a more readily accessible alternative that can allow patients to undergo treatment at home. Van Tine also described how this accelerated approval may “open the gateway” for other advancements related to the use of afami-cel and similar agents in solid tumors. “We're all working hard to get these therapies open at our institutions,” Van Tine said regarding the next steps for increasing access to afami-cel following the accelerated approval. “Knowing who [has] HLA-A*02–positive [disease], knowing who has synovial sarcoma, and being ready to trigger the screening for MAGE-A4 is in every patient's best interest. If you're one of the patients who have synovial sarcoma, you need to know your status [to determine] how we're going to integrate this into your care plan.” Reference Adaptimmune receives U.S. FDA accelerated approval of TECELRA® (afamitresgene autoleucel), the first approved engineered cell therapy for a solid tumor. News release. Adaptimmune Therapeutics. August 2, 2024. Accessed August 14, 2024. https://tinyurl.com/mw6k4hjh
In this episode of Targeted Talks, Edwin Choy, MD, PhD, discussed the FDA approval of afamitresgene autoleucel for the treatment of patients with advanced synovial sarcoma.
The FDA give an updated on the availability of obesity drugs; The CDC has issued an updated guideline on contraceptive use; The first T-cell gene therapy is approved for synovial sarcoma; Lymphir gains approval for relapsed or refractory cutaneous T-cell lymphoma; Fabhalta gains a new indication.
Follow along with our Nailed it Board/OITE Podcast Companion book. Get your copy by clicking here >> https://a.co/d/cr4i8nD Enjoy another episode from our board review series featuring Dr. Cole and Dr. Woolwine. This episode is sponsored by the American Academy of Orthopaedic Surgeons: Filled with content that has been vetted by some of the top names in orthopaedics, the AAOS Resident Orthopaedic Core Knowledge (ROCK) program sets the standard for orthopaedic education. Whether ROCK is incorporated into your residency curriculum, or you use it independently as a study tool, the educational content on ROCK is always free to residents. You'll gain the insights and confidence needed to ensure a successful future as a board-certified surgeon who delivers the best patient care. Log on at https://rock.aaos.org/.
Visit learnamastyle.com for free downloads and free courses related to writing in medicine and science. - The FDA has approved donanemab (Kisunla) for early symptomatic Alzheimer's disease, making it the third drug in a new class aimed at slowing cognitive decline in early-stage patients. Eli Lilly will make the drug available within weeks following this approval. Donanemab is an anti-amyloid monoclonal antibody that targets amyloid plaques in the brain, a key feature of Alzheimer's. - The FDA approval was based on clinical trials showing significant benefits in slowing cognitive decline despite concerns about long-term safety. The advisory committee voted unanimously in favor of the drug, with the FDA granting the approval to Eli Lilly. - The FDA has approved bedaquiline (Sirturo) for treating multidrug-resistant pulmonary tuberculosis (TB) in adults and children aged five and above. Sirturo initially received accelerated FDA clearance for adults in 2012, with later label expansions for younger patients. Bedaquiline, the first TB drug with a new action mechanism in over 40 years, inhibits mycobacterial ATP synthase, essential for energy production in TB bacteria.. - The FDA is nearing a decision on KarXT, a novel antipsychotic for schizophrenia developed by Karuna Therapeutics. KarXT has shown efficacy in reducing symptom severity in clinical trials, with a favorable side effect profile compared to older antipsychotics. Concerns about insurance coverage exist due to the availability of cheaper generics, but a decision is expected by September 26. - MDMA-assisted therapy for PTSD, developed by Lykos Therapeutics, has shown significant symptom reduction in clinical trials but faces approval challenges. Despite positive trial results, the FDA advisory panel voted against recommending the drug, citing safety concerns. The FDA's final decision is expected by August 11. - Seladelpar, under consideration for primary biliary cholangitis (PBC), is a drug Gilead recently acquired through the purchase of CymaBay. If approved by August 14, it would expand Gilead's liver disease portfolio. Clinical trials have shown seladelpar to be effective in reducing the itching associated with PBC. - TransCon PTH by Ascendis Pharma is a treatment for hypoparathyroidism, designed to replace parathyroid hormone and help patients achieve normal calcium levels. Despite manufacturing concerns delaying the FDA's decision, the drug has already been approved in Europe and the UK. A final FDA decision is expected by August 14. - Afami-cel, a T-cell receptor therapy for synovial sarcoma developed by Adaptimmune Therapeutics, awaits FDA approval by August 4. The therapy targets the MAGE A4 cancer target and is designed as a single-dose treatment. Clinical trial data supporting the application showed efficacy in treating advanced synovial sarcoma.
In this episode, we review the high-yield topic of Synovial Sarcoma from the Pathology section. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
BUFFALO, NY- February 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.” The concept of osteoarthritis (OA) as a low-grade inflammatory joint disorder has been widely accepted. Many inflammatory mediators are implicated in the pathogenesis of OA. Interleukin (IL)-18 is a pleiotropic cytokine with versatile cellular functions that are pathogenetically important in immune responses, as well as autoimmune, inflammatory, and infectious diseases. IL-17, a proinflammatory cytokine mainly secreted by Th17 cells, is upregulated in OA patients. However, the role of IL-17 in OA progression is unclear. In this new study, researchers Kun-Tsan Lee, Chih-Yang Lin, Shan-Chi Liu, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yuan-Hsin Tsai, Chia-Chia Chao, Po-Chun Chen, and Chih-Hsin Tang from National Chung-Hsing University, Taichung Veterans General Hospital, Shin-Kong Wu Ho-Su Memorial Hospital, Mackay Medical College, China Medical University, Show-Chwan Memorial Hospital, Fu-Jen Catholic University, National Taiwan Normal University, Asia University, and China Medical University Hsinchu Hospital used synovial tissues collected from healthy donors and OA patients to detect the expression level of IL-18 by immunohistochemistry stain. “Elucidation of the molecular mechanisms and main factors involved in OA pathogenesis may help with the development of novel therapeutic targets that relieve OA pain or prevent the disease from progressing.” The OA synovial fibroblasts (OASFs) were incubated with recombinant IL-17 and subjected to Western blot, qPCR, and ELISA to examine IL-18 expression level. The chemical inhibitors and siRNAs which targeted signal pathways were used to investigate signal pathways involved in IL-17-induced IL-18 expression. The microRNAs which participated IL-18 expression were surveyed with online databases miRWalk and miRDB, followed by validation with qPCR. This study revealed significantly higher levels of IL-18 expression in synovial tissue from OA patients compared with healthy controls, as well as increased IL-18 expression in OASFs from rats with severe OA. In vitro findings indicated that IL-17 dose-dependently promoted IL-18 production in OASFs. Molecular investigations revealed that the MEK/ERK/miR-4492 axis stimulated IL-18 production when OASFs were treated with IL-17. “This study provides novel insights into the role of IL-17 in the pathogenesis of OA, which may help to inform OA treatment in the future.” DOI - https://doi.org/10.18632/aging.205462 Corresponding authors - Po-Chun Chen - pcchen@ntnu.edu.tw, and Chih-Hsin Tang - chtang@mail.cmu.edu.tw Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
ChatGPT4 in medical writing and editing at learnAMAstyle.com Nascentmc.com for medical writing assistance for your company. Visit nascentmc.com/podcast for full show notes Tricuspid Valve Replacement System for Tricuspid Regurgitation The FDA approved the Evoque tricuspid valve replacement system, a first in the U.S. for a transcatheter tricuspid device, after the TRISCEND II trial showed significant improvements in TR grade and patient symptoms. TR, where the heart's valve does not close properly causing blood backflow, can now be treated with this device, which also received CE Mark approval in Europe and is produced by Edwards Lifesciences. Afami-Cel for Synovial Sarcoma The FDA is prioritizing the review of afamitresgene autoleucel (afami-cel) for advanced synovial sarcoma, based on positive results from the SPEARHEAD-1 trial showing a 39% response rate and increased survival rates. Afami-cel targets MAGE-A4 in synovial sarcoma, a rare soft tissue sarcoma, offering a new treatment option for this aggressive disease. It's manufactured by Adaptimmune Therapeutics with a decision expected by August 4, 2024. Pulsed Field Ablation for Atrial Fibrillation Boston Scientific's FARAPULSE PFA System has been FDA approved for treating intermittent atrial fibrillation, offering a non-thermal, tissue-selective ablation alternative with proven safety and efficacy. The approval was based on the ADVENT study and real-world data, highlighting shorter ablation times and no severe side effects. Boston Scientific plans an immediate U.S. launch. Shorter Turnaround Time for Axi-cel The FDA approved a manufacturing process change for axi-cel (Yescarta), reducing delivery time from 16 to 14 days, which is a CD19-directed CAR T-cell therapy for certain lymphomas. This change, granted to Kite, a Gilead Sciences subsidiary, aims to improve treatment accessibility by offering faster delivery of this personalized therapy. AI Algorithm for Cervical Cancer Screening Hologic's Genius™ Digital Diagnostics System with the Genius™ Cervical AI algorithm has been FDA approved, introducing the first digital cytology platform integrating AI for cervical cancer screening. This system digitizes traditional Pap test slides, applying AI to enhance detection of pre-cancerous and cancerous cells, improving sensitivity and enabling remote case review. It will be available in the U.S. in early 2024. Trastuzumab Deruxtecan for Solid Tumors The FDA granted priority review to trastuzumab deruxtecan for treating unresectable or metastatic HER2-positive solid tumors, potentially marking it as the first HER2-directed, tumor-agnostic therapy. Based on the DESTINY-PanTumor02 study, showing promising survival outcomes, a decision is expected in the second quarter of 2024. The drug is developed by AstraZeneca and Daiichi Sankyo.
In this episode, we review the high-yield topic of Synovium & Synovial Fluid from the Basic Science section. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
Not Just a Chiropractor for Stamford, Darien, Norwalk and New Canaan
Darien CT- Knee Pain TreatmentIf you have knee pain that won't go away your doctor has probably told you about gel shots to help the knee pain Hyaluronic acid is a substance that occurs naturally in the synovial fluid of joints, providing lubrication and cushioning. Gel shots for knee pain typically refer to intra-articular injections of viscosupplements, also known as hyaluronic acid injections the effectiveness of hyaluronic acid injections for knee pain remains a topic of debate among medical professionals The Knee on Trac is a therapy device that stimulates the knee to produce synovial fluid naturally. The synovium is responsible for producing synovial fluid naturally Synovial fluid lubricates the joint surfaces, reducing friction during movement and allowing for smooth articulation of the bones The Knee on Trac allows your knee to produce more of it's own synovial fluid to stop your knee pain The lubricating effect heals meniscus tears and provides cushioning to your knee Core Health Darien is the only facility in Connecticut to offer The Knee on Trac Before you consider knee replacement or knee surgery call 203-656-3636 and try the Knee on Trac This podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message. I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4Core Health Darien-Dr.Brian Mc Kay 551 Post RoadDarien CT 06820203-656-363641.0833695 -73.46652073GMP+87 Darien, Connecticuthttps://youtu.be/WpA__dDF0O041.0834196 -73.46423349999999https://darienchiropractor.comhttps://darienchiropractor.com/darien/darien-ct-understanding-pain/Find us on Social Mediahttps://chiropractor-darien-dr-brian-mckay.business.site https://www.youtube.com/channel/UCNHc0Hn85Iiet56oGUpX8rwhttps://docs.google.com/spreadsheets/d/1nJ9wlvg2Tne8257paDkkIBEyIz-oZZYy/edit#gid=517721981https://goo.gl/maps/js6hGWvcwHKBGCZ88https://www.youtube.com/my_videos?o=Uhttps://www.linkedin.com/in/darienchiropractorhttps://www.facebook.com/ChiropractorBrianMckayhttps://sites.google.com/view/corehealthdarien/https://sites.google.com/view/corehealthdarien/home
Ask the Experts: Medical vs Surgical Management of Synovial Cyst Bryan Lee, MD Scott Kreiner, MD Jacob Rohrs, MD Edward Dohring, MD
In this episode, we review the high-yield topic of Synovial Facet Cyst from the Spine section. Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
Episode 146: RA vs OA Future Dr. Magurany explains how to differentiate rheumatoid arthritis from osteoarthritis. Written by Thomas Magurany, MSIV, Ross University School of Medicine. Comments by Hector Arreaza, MD. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.1. Etiology: Rheumatoid Arthritis (RA): RA is an autoimmune disease wherein the immune system mistakenly attacks healthy tissues, particularly the synovial joints, usually between the ages of 30-50. Genetic predisposition, environmental factors such as smoking or infections, hormonal imbalances, and lower socioeconomic status have been associated with an increased risk of developing RA(1).Osteoarthritis (OA): OA primarily arises due to mechanical stress on the joints over time. Factors contributing to OA include age, obesity, joint injury or trauma, repetitive joint use or overuse, genetic abnormalities in collagen structure, and metabolic disorders affecting cartilage metabolism (2).The greatest risk factor for the development of OA is age with most patients presenting after 45 years of age. The greatest modifiable risk factor for OA is weight. People with a BMI >30 were found to have a 6.8 times greater risk of developing OA. (3) Primary OA is the most common and is diagnosed in the presence of associated risk factors such as: older age, female gender, obesity, anatomical factors, muscle weakness, and joint injury (occupation/sports activities) in the absence of trauma or disease. Secondary OA occurs alongside a pre-existing joint deformity including trauma or injury, congenital joint disorders, inflammatory arthritis, avascular necrosis, infectious arthritis, Paget disease, osteopetrosis, osteochondritis dissecans, metabolic disorders (hemochromatosis, Wilson's disease), Ehlers-Danlos syndrome, or Marfan syndrome.2. Pathogenesis:Rheumatoid Arthritis (RA):In some patients, RA is triggered by some sort of environmental factor in a genetically predisposed person. The best example is tobacco use in a patient with HLA-DRB1. The immune response in RA starts at sites distant from the synovial joints, such as the lung, gums, and GI tract. In these tissues, modified proteins are produced by biochemical reactions such as citrullination. (4)In RA, an abnormal immune response leads to chronic inflammation within the synovium lining the joints. The inflammatory cytokines released cause synovitis and lead to the destruction of articular cartilage and bone erosion through pannus formation. Immune cells infiltrate the synovium causing further damage. (4) In summary: formation of antibodies to citrullinated proteins, these antibodies begin attacking wrong tissues.Osteoarthritis (OA):The primary pathological feature of OA is the degeneration of articular cartilage that cushions the joints causing surface irregularity, and focal erosions. These changes progress down the bone and eventually involve the entire joint surface. Mechanical stress triggers chondrocyte dysfunction, leading to an imbalance between cartilage synthesis and degradation that cause cartilage outgrowths that ossify and form osteophytes. This results in the release of enzymes that degrade the extracellular matrix, leading to progressive cartilage loss. As more of the collagen matrix is damaged, chondrocytes undergo apoptosis. Improperly mineralized collagen causes subchondral bone thickening; in advanced disease, bone cysts infrequently occur (5). In summary: Osteophytes formation and cartilage loss.3. Clinical Presentation:Rheumatoid Arthritis (RA):The most common and predominant symptoms include joint pain and swelling, usually starting insidiously over a period of weeks to months. RA typically affects multiple joints symmetrically, commonly involving small joints of the hands, wrists, feet and progresses to involve proximal joints if left untreated. Morning stiffness lasting more than an hour is a characteristic feature. The affected joint will be painful if pressure is applied to the joint or on movement with or without joint swelling. Synovial thickening with a "boggy" feel on palpation will be noted. The classical physical findings of ulnar deviation, metacarpophalangeal joint subluxation, swan neck deformity, Boutonniere deformity, and the "bowstring" sign (prominent and tight tendons on the dorsum of the hand) are seen in advanced chronic disease. (4) Around ¼ of patients with RA may present with rheumatoid noduleswhich are well demarcated, flesh-colored subcutaneous lumps. They are usually described as being doughy or firm and are not typically tender unless they are inflamed. They are usually found on areas susceptible to repeated trauma or pressure and include the elbows, fingers and forearms. Osteoarthritis (OA):OA primarily affects weight-bearing joints such as knees, hips, spine, and hands. Symptoms include joint pain aggravated by activity and relieved with rest, morning stiffness lasting less than 30 minutes, joint swelling due to secondary inflammation, and occasionally the formation of bony outgrowths called osteophytes (6). Tenderness may be present at joint lines, and there may be pain upon passive motion. Classic physical exam findings in hand OA include Heberden's nodes (posterolateral swellings of DIP joints), Bouchard's nodes (posterolateral swellings of PIP joints), and “squaring” at the base of the thumb (first Carpal-Metarcapal or CMC joints), bony enlargement, crepitus, effusions (non-inflammatory), and a limited range of motion. Patients may also experience bony swelling, joint deformity, and instability (patients complain that the joint is “giving way” or “buckling,” a sign of muscle weakness). (5)4. Lab findings:Rheumatoid Arthritis: Laboratory testing often reveals anemia of chronic disease (increased ferritin, decreased iron and TIBC) and thrombocytosis. Neutropenia may be present if Felty syndrome is present. RF is present in 80-90% of patients with a sensitivity of 69%. In patients who are asymptomatic or those that have arthralgias, a positive RF and especially CCP predicts the onset of clinical RA. Patients with RA with RF, ACPA, or both are designated as having seropositive RA. About 10% of RA patients are seronegative. ESR and levels of CRP are usually elevated in patients with active disease and can be used to assess disease activity. The synovial fluid in RA will also reveal low C3 and C4 levels despite elevated serum levels.(4) Some non-specific inflammatory markers such as ESR, CRP can help you guide your diagnosis of RA.Osteoarthritis:Lab findings are not significant. Clinical diagnosis if the following are present: 1) pain worse with activity and better with rest, 2) age more than 45 years, 3) morning stiffness lasting less than 30 minutes, 4) bony joint enlargement, and 5) limitation in range of motion. Blood tests such as CBC, ESR, rheumatoid factor, ANA are usually normal but usually ordered to rule out an inflammatory process. Synovial fluid should show a white blood cell count less than 2,000/microL, predominantly mononuclear cells (non-inflammatory). X-rays of the affected joint can show findings consistent with OA, such as marginal osteophytes, joint space narrowing, subchondral sclerosis, and cysts; however, radiographic findings do not correlate to the severity of the disease and may not be present early in the disease. (5)5. Treatment Approaches:Rheumatoid Arthritis (RA):There is no cure for RA.The goal of treatment in RA is inducing remission and optimizing quality of life. This is initially done by beginning DMARDs, include methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide. Methotrexate is the initial DMARD of choice. Anti-TNF-alpha inhibitors include etanercept, infliximab, adalimumab, golimumab, and certolizumab may be used if DMARDs fail. NSAIDs are used to control joint pain and inflammation. Corticosteroids may be used as a bridge therapy to DMARDs in a newly diagnosed patient with a very active disease. (7) Coronary artery disease has a strong association with RA. RA is an independent risk factor for the development of coronary artery disease (CAD) and accelerates the development of CAD in these patients. Accelerated atherosclerosis is the primary cause of morbidity and mortality. There is increased insulin resistance and diabetes mellitus associated with RA and is thought to be due to chronic inflammation. When treated with specific DMARDs such as hydroxychloroquine, methotrexate, and TNF antagonists, there was a marked improvement in glucose control in these patients. (8) RA is not just a disease of the joints, it is able to affect multiple organ systems.Osteoarthritis (OA):OA treatment aims at reducing pain and improving joint function through a combination of non-pharmacological interventions like exercise programs tailored to strengthen muscles around affected joints, weight management strategies, and assistive devices like braces or walking aids if required (9). Medications including analgesics or nonsteroidal anti-inflammatory drugs may be prescribed for pain relief when necessary. Duloxetine has modest activity in relieving pain associated with OA. Intraarticular glucocorticoid joint injections have a variable response but are an option for those wanting to postpone surgical intervention. In severe cases where conservative measures fail, surgical options like joint replacement may be considered (9). Weight loss is a critical intervention in those who have overweight and obesity; each pound of weight loss can decrease the load across the knee 3 to 6-fold. (5) Summary: Medications (NSAIDs, topical, duloxetine), weight loss, PT, intraarticular injections of corticosteroids, and joint replacement.________________________________Conclusion: Now we conclude episode number 146, “RA vs. OA.” Future Dr. Magurany explained that rheumatoid arthritis is an autoimmune disease that presents with joint pain and inflammation, mostly on hands and small joints, accompanied by morning stiffness longer than 1 hour. The rheumatoid factor and ACPA may be positive in a percentage of patients but not always. The base of treatment is early treatment with disease-modifying antirheumatic drugs to induce remission of the disease. OA affects weight-bearing joints with little to no inflammation, treatment is mainly lifestyle modifications, analgesics, intraarticular injections, and joint replacement.This week we thank Hector Arreaza and Thomas Magurany. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Myasoedova E, Crowson CS & Gabriel SE et al. (2010). Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955-2007. Arthritis and Rheumatism, 62(6), 1576-1582.Goldring MB & Goldring SR. (2007). Osteoarthritis. Journal of Cellular Physiology, 213(3), 626-634.King LK, March L, Anandacoomarasamy A. Obesity & osteoarthritis. Indian J Med Res. 2013;138(2):185-93. PMID: 24056594; PMCID: PMC3788203.Chauhan K, Jandu JS, Brent LH, et al. Rheumatoid Arthritis. [Updated 2023 May 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.Sen R, Hurley JA. Osteoarthritis. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.Hunter DJ, Bierma-Zeinstra S. & Eckstein F. (2014). OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for primary hip and knee osteoarthritis: An expert consensus initiative of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Task Force in collaboration with the Osteoarthritis Research Society International (OARSI). Osteoarthritis Cartilage, 22(7), 363-381.van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW. Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med. 2002 Jan 1;136(1):1-12. doi: 10.7326/0003-4819-136-1-200201010-00006. PMID: 11777359.Nicolau J, Lequerré T, Bacquet H, Vittecoq O. Rheumatoid arthritis, insulin resistance, and diabetes. Joint Bone Spine. 2017 Jul;84(4):411-416.Fernandes L, Hagen KB, Bijlsma JWJ et al. (2019). EULAR recommendations for non-pharmacological core management of hip and knee osteoarthritis. Annals of Rheumatic Diseases, 79(6), 715-722.Royalty-free music used for this episode: "Driving the Point." Downloaded on July 29, 2023, from https://www.videvo.net/
Drs. Garett Pearson and Heidi Reesink, authors of "Synovial sepsis diagnostics and antimicrobial resistance: a one-health perspective in: Journal of the American Veterinary Medical Association Volume 261 Issue 8 (2023) (avma.org)" and "Equine synovial sepsis laboratory submissions yield a low rate of positive bacterial culture and a high prevalence of antimicrobial resistance in: American Journal of Veterinary Research - Ahead of print (avma.org)" discuss the current state of diagnostics for synovial sepsis. Hosted by Associate Editor Dr. Sarah Wright and Editor-in-Chief Dr. Lisa Fortier.INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA OR AJVR?JAVMA: https://avma.org/JAVMAAuthorsAJVR: https://avma.org/AJVRAuthorsFOLLOW US:JAVMA:Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR: Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA and AJVR LinkedIn: https://linkedin.com/company/avma-journals#VeterinaryVertexPodcast #JAVMA #AJVRINTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals
A new case report was published in Oncotarget's Volume 14 on July 7, 2023, entitled, “Intrathoracic synovial sarcoma with BRAF V600E mutation.” Synovial sarcoma (SS) is a highly malignant mesenchymal tumor that occurs mainly in adolescents and young adults. The treatment of SS is multimodal, involving surgery, radiotherapy and chemotherapy. The overall prognosis is generally quite satisfactory in children and adolescents with localized SS at diagnosis. However, the outcome remains poor for patients who relapse, with a reported 5-year post-relapse survival of around 30%. In this new paper, researchers Ida Russo, Sabina Barresi, Pier Luigi Di Paolo, Valentina Di Ruscio, Giada Del Baldo, Annalisa Serra, Silvia Vallese, Evelina Miele, Angela Mastronuzzi, Rita Alaggio, Andrea Ferrari, and Giuseppe Maria Milano from Italy's Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) report the case of a 15-year-old boy with intrathoracic synovial sarcoma who relapsed after standard chemotherapy, surgery and radiotherapy. The molecular analysis of the tumor identified a BRAF V600E mutation at time of progression of relapsed disease under third line systemic treatment. This mutation is commonly seen in melanomas and papillary thyroid cancers, but less prevalent (typically
In this episode, we review the high-yield topic of Synovial Sarcoma from the Pathology section. Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
Kelli Ritschel Boehle's son Nick passed away from Synovial Sarcoma in March of 2012. During his cancer battle which lasted for 3 1/2 years, Nick was undergoing a clinical trial at the National Institute of Health when he met a young man named Nate. Nick was just young enough after he was diagnosed to be able to take advantage of the Make A Wish Foundation who granted he and his family a trip to Hawaii but Nate was too old to be given a similar opportunity. On today's podcast, Kelli will talk about how upset Nick was about Nate and asked his mother if she could help him in any way. .After Nick passed away, not only did Kelli help Nate, but she is now helping many other cancer patients who range in age from 18-24 by starting the Nickolas Ritschel Foundation which grants wishes to this age group, in similar fashion to what the Make A Wish Foundation has been doing for many many years.
In this episode, we review the high-yield topic of Synovial Facet Cyst from the Spine section. **This episode is sponsored by Robin Healthcare. Learn more about what Robin can do for your current or future Orthopaedic surgery practice: https://www.robinhealthcare.com/orthobullets Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://anchor.fm/orthobullets/message
Not Just a Chiropractor for Stamford, Darien, Norwalk and New Canaan
What is The Knee on Trac?The Knee on Trac is a medical device that helps your knee joint to produce more synovial fluid. In case you do not know what synovial fluid is I will tell you. The synovial fluid acts like a lubricant for the knee. Synovial fluid is made up of many components like hyaluronan, lubricin, proteinase, collagenases, and prostaglandins. The knee takes on a great deal of stress and can be a major cause of discomfort for many people. When the stress on the knee becomes too great it can start to wear down or tear the meniscus causing irritation and knee pain. Adequate levels of synovial fluid helps protect the knee from inflammation which leads to degeneration of the knee.People with knee pain who want to avoid knee surgery or even knee replacement would do themselves a great service by trying out the Knee on Trac. It gently tractions the knee joint and stimulates the synovium to produce soothing synovial fluid. Less inflammation means less pain. Just consider how your car runs when it has the proper amount of oil in the engine. Your knee is a mechanical wonder my job is to keep it running as smoothly as possible.Core Health Darien-Dr.Brian McKay203-656-3636This podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message. I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4
Not Just a Chiropractor for Stamford, Darien, Norwalk and New Canaan
Understanding Chronic Knee Pain What's the most common cause of chronic knee pain?People often ask me, "How do I stop constant knee pain?". My first question back is usually what are you doing to aggravate your knee? Did you have an accident? Is there an old sports injury? Did your parents have arthritis? Do you exercise regularly? Are you overweight? All of these and more are solid reasons to have chronic knee pain There are so many ways that someone can have chronic knee pain. It is nice to know what caused knee pain but if you have chronic knee pain figuring out how to fix it is more important. Let's get into how we do this at Core Health Darien.How to Stop Chronic Knee Pain?It all starts with an examination. Chances are that if you have had knee pain for more than 12 months you will need advanced imaging. X-rays are less expensive and might suffice but MRIs are a better diagnostic tool to see soft tissue injuries. Your doctor along with a radiologist's report will identify the problem. Now a solution for your chronic knee pain can be derived.For my patients, once I determine that I can help their knee issues I begin to order the Knee on Trac. The Knee on Trac is a special therapy that helps your body to produce more synovial fluid. Synovial fluid is a lubricant. Since there is pain there will be inflammation. Synovial fluid acts to quell the swelling associated with pain and inflammation.How to tell if your knee pain is serious?When simple activities of daily living start to become more of a burden you will know that your chronic knee pain is in need of attention. When your knee pain is unbearable you probably are doing more damage. When knee pain is left untreated it will only worsen. Quite often people with knee pain think that since there was no trauma or injury that it should go away on its own. This is not true, it is not normal to have knee pain for months. Pain is your body's way of saying something is wrong. Pain left untreated can last years, consider all that you are missing out on in life.How to Fix Chronic Knee PainAs mentioned earlier the Knee on Trac is a cornerstone of knee pain care at Core Health Darien. We also use shockwave therapy to break up muscle adhesions and enhance blood flow via angiogenesis. A newer method of treating chronic knee pain is to use blood flow, restriction bands. The elastic bands are placed at the hips and limit blood flow and therefore oxygen to the muscles of the leg. This creates a deficit that causes a rush of oxygenated blood into damaged tissue to rejuvenate the muscles and to some extent the ligaments. Core Health Darien also offers Tri-Genics as a way to stimulate nerve fibers from the muscles and tendons to the spinal cord to help inhibit pain. We also use laser therapy to allow the body to ramp up the production of nitric oxide, a powerful vasodilator to drive more healing blood to the muscles causing your chronic knee pain.When Knee Pain Doesn't Go Away?Call us 203-656-3636 and make an appointment! Now if you have been told that you require a knee replacement we may not be a good fit. We have helped some people after knee replacement failed and they still had knee pain. Having sThis podcast welcomes your feedback here are several ways to reach out to me. If you have a topic you would like to hear about send me a message. I appreciate your listening. Dr. Brian Mc Kayhttps://twitter.com/DarienChiro/https://www.facebook.com/ChiropractorBrianMckayhttps://chiropractor-darien-dr-brian-mckay.business.sitehttps://podcasts.apple.com/us/podcast/not-just-chiropractor-for-stamford-darien-norwalk-new/id1503674397?uo=4
In this episode, we review the high-yield topic of Synovial Sarcoma from the Pathology section. Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://anchor.fm/orthobullets/message
Arthritis in the knees, hips, or wrists is extremely common, particularly in the second half of life. If you're feeling pain and inflammation in your joints, the natural impulse is to reduce your movement and limit your activities, but movement is medicine. The fluid between your joints wants and needs movement to nourish, heal, and lubricate your connective tissues. But how much movement is helpful? And how often? There are no easy answers to these questions, but yoga for arthritis teacher and best-selling author, Ann Swanson, joins us to share her personal and professional findings. Listen to learn: The importance of strength as we age How to modify for your body and your pain How hyaline (articular) cartilage health is crucial and how degradation of this tissue can lead to pain and restricted movement How the synovial fluid around your joints responds to movement and compression Links Ann's Site ABOUT OUR GUEST Ann Swanson is a certified yoga therapist and author of the best-selling book, Science of Yoga. She specializes in helping people manage stress, pain and arthritis.
Today we discuss the anatomy of the knee, the largest joint in the human body. Let's explore movements, function, bones involved, main ligaments and the menisci. We will also cover one of Sam's favourite topics, articular cartilage. Terms covered this week; The femur, tibia, fibular and patella bones. Synovial joints, fluid and capsule. The articular and hyaline cartilage and bursae. Cruciate ligaments (anterior & posterior), & collateral ligaments of the knee (medial and lateral). Condyles vs Epicondyles, tibial plateau and menisci.
Synovial Sarcomas are rare malignant tumors of soft tissue. Unlike most soft tissue sarcomas they are more likely to affect younger individuals. This tumor type is unique because of a common chromosomal translocation and mutation. They also have a high predilection of metastasis to lung and to the lymph nodes. Links & Article(s) Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D, Ghert M. Synovial Sarcoma: A Clinical Review. Curr Oncol. 2021;28(3):1909-1920. Published 2021 May 19. doi:10.3390/curroncol28030177 Find out More about our Doctors: Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/ Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/
The Evidence Based Chiropractor- Chiropractic Marketing and Research
Synovial folds are a critical spinal structure that chiropractors work with everyday in practice. In this episode we explore the landmark study showcasing the histology, function, and challenges associated with these important and often overlooked structures.Episode Notes:Synovial folds - a pain in the neck?Designed by a Podiatrist over 30 years ago after seeing similarities in many of the custom devices he was creating, PowerStep offers an affordable, same day solution that combines support and cushioning. Want to try a pair for yourself, click here for a free sample pair.The Smart Chiropractor powers your patient journey to provide you with more qualified leads, more new patients, better patient retention, and consistent reactivations, without any money spent on advertising.ChiroMatchMakers specializes in DC and CA hiring. We have over 100 positions available right now with salaries starting at $85K. Discover the available positions today by clicking here. Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!
On this episode of the Dr. Tyna Show, I am sitting down with Dr. Shawn Baker. He is the author of The Carnivore Diet. Dr. Baker has spent 20 years as an Orthopedic Surgeon and his insight is incredibly valuable. I can't wait for you to listen. On This Episode We Cover: Orthopedic surgeries Dextrose Prolotherapy Fixing underlying issues in your body Stem cell therapy Issues with stem cell therapy if you are inflamed Ultra processed foods Auto immune responses Asthma and autoimmunity Why arthritis is common but not normal Synovial inflammation Knee replacements Osteoporosis Vegans and bone health Leptin Leptin resistance Carnivore Diet Follow Dr. Shawn Baker on Instagram Dr. Bakers Website Follow Dr. Tyna on Instagram Download my FREE BOOK and get on my email list. Follow me on my Substack Blog Sponsored by: The Dr. Tyna Store Get 10% OFF my Main Store and my CBD Store here. Bundle MetaboFlex and CarbBlunt w/code METABOLISM10 Further Listening: The Belly Fat Effect with Mike Mutzel The Carnivore Code with Dr. Paul Saladino
Episode 89: Gonorrhea Basics. Written by Robert BensacenezRobert, Dr. Schlaerth, and Dr. Arreaza discuss the basics of gonorrhea, including presentation, treatment, and even a potential gonococcal vaccine.Introduction: Gonorrhea is commonly known as “the clap” or “the drip”. This ancient disease, described as “the perilous infirmity of burning” in a book called The History of Prostitution, has been treated with many remedies throughout history, including mercury, sulfur, silver, multiple plants, and even gold. Today we will discuss the clinical features, diagnosis, and current therapy of gonorrhea. By the way, did you know that gonorrhea in Spanish is used as an insult in Colombia? Well, now you know it. Definition: Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae (common name gonococcus), which is a gram-negative, intracellular, aerobic, diplococci. This disease leads to genitourinary tract infections such as urethritis, cervicitis, pelvic inflammatory disease (PID), and epididymitis. This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. ___________________________Gonorrhea. Written by Robert Besancenez, MS4, Ross University School of Medicine. Moderated and edited by Hector Arreaza, MD. Discussion participation by Katherine Schlaerth, MD. Epidemiology: The disease primarily affects individuals between 15–24 years of age (half of the STI patients in the US). CDC estimates that approximately 1.6 million new gonococcal infections occurred in 2018. Incidence rates are highest among African Americans, American Indians, and Hispanic populations.Transmission is sexual (oral, genital, or anal) or perinatal (causing gonococcal conjunctivitis in neonates). Risk factors include unsafe sexual behaviors (lack of barrier protection, multiple partners, men who have sex with men (MSM), and asplenia, complement deficiencies. Individuals with low socioeconomic status are at the highest risk: poor access to medical treatment and screening, poor education, substance use, and sex work. Presentation: The incubation period is ~ 2–7 days, and sometimes patients do not develop any symptoms. Urogenital infection: Gonorrhea is commonly asymptomatic, especially in women, which increases the chance of further spreading and complications. When symptoms are present, typical symptoms include purulent vaginal or urethral discharge (purulent, yellow-green, possibly blood-tinged). Discharge is less common in female patients. Urinary symptoms include dysuria, urinary frequency, and urgency. Male: - Typical presentation is urethritis. - Penile shaft edema without other signs of inflammation.- Epididymitis: unilateral scrotal fullness sensation, scrotal swelling, redness, tenderness, relief of pain with elevation of scrotum —Prehn Sign— and positive cremasteric reflex.- Robert: Prostatitis: fever, chills, general malaise, pelvic or perineal pain, cloudy urine, prostate tenderness (examine prostate gently). Female: - Cervicitis: Friable cervix and discharge (purulent, yellow, malodorous), - PID: pelvic or lower abdominal pain, dyspareunia, fever, cervical discharge, cervical motion tenderness but also uterine or adnexal tenderness, abnormal intermenstrual bleeding. PID can be subclinical and diagnosed retroactively when tubal occlusion is discovered as part of a workup for infertility. PID can cause Fitz-Hugh-Curtis syndrome (perihepatitis with RUQ pain).- Bartholinitis presents with introitus pain, edema, and discharge from the labia. - Vulvovaginitis may occur but is rare (due to the tissue preference of gonococci)Extragenital infection: Proctitis: Rectal purulent discharge, possible anorectal bleeding and pain, rectal mucosa inflammation, or rectal abscess (less common).Pharyngitis: sore throat, pharyngeal exudate, cervical lymphadenitis. Disseminated gonococcal infection (DGI): Triad of arthritis, pustular skin lesions, and tenosynovitis. As mentioned in Episode 46, on December 23, 2020, the California Department of Public Health (CDPH) sent a “Dear Colleague” letter to warn the medical community about the increased cases of DGI in California and Michigan. Increased cases may be caused by decreased STD testing and treatment because of the COVID-19 pandemic, and not necessarily because of a more virulent strain of gonorrhea. Later, treatment of gonorrhea was updated because of resistance. Epidemiology: ∼ 2% of cases. Most common in individuals younger than 40 years old, the female to male ratio is 4:1. A history of recent symptomatic genital infection is uncommon. Asymptomatic infections increase the risk of dissemination due to delayed diagnosis and treatment. Clinical features: Two distinct clinical presentations are possible. Arthritis-dermatitis syndrome:Polyarthralgias: migratory, asymmetric arthritis that may become purulent.Tenosynovitis: simultaneous inflammation of several tendons (e.g. fingers, toes, wrist, ankle).Dermatitis: vesicular, pustular, or maculopapular lesions, possibly with a necrotic or hemorrhagic center. Most commonly distributed on the trunk, extremities (sometimes involving the palms and soles). Typically, < 10 lesions with a transient course (subside in 3–4 days). Additional manifestations: fever and chills (especially in the acute phase). Purulent gonococcal arthritis: Abrupt inflammation in up to 4 joints (commonly knees, ankles, and wrists). No skin manifestations, rarely tenosynovitis. Genitourinary manifestations in only 25% of affected individuals. Not to be confused with reactive arthritis. Health care providers living in California: Order Nucleic acid amplification test (NAAT) and culture specimens from urogenital, extragenital mucosal sites (e.g., pharyngeal and rectal), and from disseminated sites (e.g., skin, synovial fluid, blood, and cerebrospinal fluid) before initiating empiric antimicrobial treatment for patients with suspected DGI. Report within 24 hours of diagnosis to the California Department of Public Health. Complications of DGI: sepsis with endocarditis, meningitis, osteomyelitis, or pneumonia. Diagnosis of gonorrhea: The test of choice is Nucleic acid amplification testing (NAAT) of first-catch urine or swabs of urethra, endocervix and pharynx, and synovial fluid in disseminated infection. Other possible tests: gram stains and bacterial cultures (Thayer-Martin agar, useful for antibiotic resistance, results may take 48 hours, sensitivity is lower than NAAT.)Synovial fluid analysis: Appearance of fluid can be clear or cloudy (purulent), high Leukocyte count (up to 50,000 cells/mm3): especially segmented neutrophils, gram stain positive in < 25% of cases. Treatment: Ceftriaxone and doxycycline for uncomplicated cases, but may require different approaches in case of allergies or intolerance to these antibiotics, or in severe cases. Uncomplicated gonorrhea (affecting cervix, urethra, rectum, pharynx)First-line treatment: single-dose ceftriaxone 500 mg IM (1 G for patients >150 Kg) PLUS doxycycline 100 mg PO twice a day for 7 days If a chlamydial infection has not been excluded.During pregnancy: Ceftriaxone PLUS single-dose azithromycin 1 gram PO(doxy is contraindicated – teratogen) Complicated gonorrhea (salpingitis, adnexitis, PID/ epididymitis, orchitis)Single-dose ceftriaxone IM PLUS doxycycline PO for 10–14 days (women may require additional administration of Metronidazole PO for 14 days). DGICeftriaxone IV every 24 hours for 7 days In case Chlamydia infection has not been ruled out: PLUS doxycycline PO twice a day for 7 daysDrainage of purulent joint(s) Sequelae: Without treatment, a prolonged infection may lead to complications, such as hymenal and tubal synechiae that lead to infertility in women. Prevention:-Screening for gonorrhea (USPSTF recommendations, September 2021, Grade B): Annual NAAT screening of gonorrhea AND chlamydia for sexually active women ≤ 24 years (including pregnant persons) or > 25 years with risk factors (e.g. new or multiple sex partners, sex partner with an STI, etc.). Evaluate for other STIs if positive (e.g. chlamydia, syphilis, and HIV). There is insufficient evidence to recommend for or against screening gonorrhea in asymptomatic males (Grade I).In all patients: Evaluate and treat the patient's sexual partners from the past 60 days. Provide expedited partner therapy if the timely evaluation of sexual partners is not feasible. Single-dose cefixime PO (if chlamydia has been excluded in the patient) OR Single-dose cefixime PO PLUS doxycycline PO for 7 days. Sexual partners must be treated simultaneously to avoid reinfections. A possible gonococcal vaccine: A gonococcal vaccine is theoretically possible, let's remember that the meningococcal vaccine exists. Meningococcus is closely related to gonococcus. A study published in 2017 showed that MeNZB® (a vaccine used in New Zealand until 2011 to fight against a meningitis epidemic) provided partial protection against gonorrhea. Food for thought for you guys. Conclusion: Let's remember to screen asymptomatic women for gonorrhea, identify symptomatic patients and start treatment promptly, and prevent serious complications, and more importantly, let's promote safe sex practices to prevent this disease.Now we conclude our episode number 89 “Gonorrhea Basics”. Gonorrhea affects mainly the urogenital area, but it can spread to the pharynx, rectum, skin, and even joints. When you see septic arthritis in patients with high risk for gonorrhea, suspect disseminated gonococcal infection and start treatment promptly. Even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created for educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Robert Besancenez, and Katherine Schlaerth. Audio edition: Suraj Amrutia. See you next week! _____________________References:Seña, Arlene C, MD, MPH; and Myron S Cohen, MD. Treatment of uncomplicated Neisseria gonorrhoeae infections, UpToDate, updated on Jan 27, 2022. Accessed on April 5, 2022. https://www.uptodate.com/contents/treatment-of-uncomplicated-neisseria-gonorrhoeae-infections Ghanem, Khalil G, MD, PhD. Clinical manifestations and diagnosis of Neisseria gonorrhoeae infection in adults and adolescents, UpToDate, updated on Sep 17, 2021, accessed on April 5, 2022. https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-neisseria-gonorrhoeae-infection-in-adults-and-adolescents Klausner, Jeffrey D, MD, MPH. Disseminated gonococcal infection, UpToDate, updated on March 3, 2022. Accessed on April 5, 2022. https://www.uptodate.com/contents/disseminated-gonococcal-infection Petousis-Harris H, Paynter J, Morgan J, et al. Effectiveness of a group B OMV meningococcal vaccine on gonorrhea in New Zealand – a case control study. Abstract presented at: 20th International Pathogenic Neisseria Conference. Manchester, UK; 2016.
Not sure how to interpret the results of an arthrocentesis you ordered? In this BuzzBite, Andrew walks through the four main classes of joint effusions and the hallmark lab patterns of each.
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