Podcasts about plos medicine

​In a groundbreaking new study, researchers have developed a blood and urine test capable of identifying how much ultra-processed food is in your diet. By analyzing metabolites—chemicals produced as the body breaks down food—researchers can now distinguish between individuals who consume high amounts of ultra-processed foods and those who eat little to none. Listen in this week as Dee discusses the details of this study and how the test works, what it means for the future of nutrition research and personalized nutrition, and how it could help guide healthier food choices.Reference: Abar, L., Steele, E. M., Lee, S. K., Kahle, L., Moore, S. C., Watts, E., O'Connell, C. P., Matthews, C. E., Herrick, K. A., Hall, K. D., O'Connor, L. E., Freedman, N. D., Sinha, R., Hong, H. G., & Loftfield, E. (2025). Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial. PLoS Medicine, 22(5), e1004560. https://doi.org/10.1371/journal.pmed.1004560

Ioannidis, J. P. A. (2005). Why Most Published Research Findings Are False. PLoS Medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124 Neher, A. (1967). Probability Pyramiding, Research Error and the Need for Independent Replication. The Psychological Record, 17(2), 257–262. https://doi.org/10.1007/BF03393713 Moonesinghe, R., Khoury, M. J., & Janssens, A. C. J. W. (2007). Most Published Research Findings Are False—But a Little Replication Goes a Long Way. PLOS Medicine, 4(2), e28. https://doi.org/10.1371/journal.pmed.0040028 Stroebe, W. (2016). Are most published social psychological findings false? Journal of Experimental Social Psychology, 66, 134–144. https://doi.org/10.1016/j.jesp.2015.09.017 Diekmann, A. (2011). Are Most Published Research Findings False? Jahrbücher Für Nationalökonomie Und Statistik, 231(5–6), 628–635. https://doi.org/10.1515/jbnst-2011-5-606 Goodman, S., & Greenland, S. (2007). Why most published research findings are false: Problems in the analysis. PLoS Medicine, 4(4), e168. Ioannidis, J. P. A. (2007). Why most published research findings are false: Author's reply to Goodman and Greenland. PLoS Medicine, 4(6), e215.  

Die Themen in den Wissensnachrichten: +++ Partielle Sonnenfinsternis am Samstag +++ Genmutation macht Pferde so ausdauernd +++ Artus und Merlin aus einem Bucheinband gezaubert +++**********Weiterführende Quellen zu dieser Folge:Update ErdeDie partielle Sonnenfinsternis vom 29. März 2025/ Haus der Astronomie, 24.03.2025Running a genetic stop sign accelerates oxygen metabolism and energy production in horses/ Science, 28.03.2025First 1,000 fungi on IUCN Red List reveal growing threats - IUCN Red List/ IUCN, 27.03.2025Pharmacogenetics and adverse drug reports: Insights from a United Kingdom national pharmacovigilance database/ Plos Medicine, 27.03.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Dr. Gary Null provides a commentary on "Universal  Healthcare"       Universal Healthcare is the Solution to a Broken Medical System Gary Null, PhD Progressive Radio Network, March 3, 2025 For over 50 years, there has been no concerted or successful effort to bring down medical costs in the American healthcare system. Nor are the federal health agencies making disease prevention a priority. Regardless whether the political left or right sponsors proposals for reform, such measures are repeatedly defeated by both parties in Congress. As a result, the nation's healthcare system remains one of the most expensive and least efficient in the developed world. For the past 30 years, medical bills contributing to personal debt regularly rank among the top three causes of personal bankruptcy. This is a reality that reflects not only the financial strain on ordinary Americans but the systemic failure of the healthcare system itself. The urgent question is: If President Trump and his administration are truly seeking to reduce the nation's $36 trillion deficit, why is there no serious effort to reform the most bloated and corrupt sector of the economy? A key obstacle is the widespread misinformation campaign that falsely claims universal health care would cost an additional $2 trillion annually and further balloon the national debt. However, a more honest assessment reveals the opposite. If the US adopted a universal single-payer system, the nation could actually save up to $20 trillion over the next 10 years rather than add to the deficit. Even with the most ambitious efforts by people like Elon Musk to rein in federal spending or optimize government efficiency, the estimated savings would only amount to $500 billion. This is only a fraction of what could be achieved through comprehensive healthcare reform alone. Healthcare is the largest single expenditure of the federal budget. A careful examination of where the $5 trillion spent annually on healthcare actually goes reveals massive systemic fraud and inefficiency. Aside from emergency medicine, which accounts for only 10-12 percent of total healthcare expenditures, the bulk of this spending does not deliver better health outcomes nor reduce trends in physical and mental illness. Applying Ockham's Razor, the principle that the simplest solution is often the best, the obvious conclusion is that America's astronomical healthcare costs are the direct result of price gouging on an unimaginable scale. For example, in most small businesses, profit margins range between 1.6 and 2.5 percent, such as in grocery retail. Yet the pharmaceutical industrial complex routinely operates on markup rates as high as 150,000 percent for many prescription drugs. The chart below highlights the astronomical gap between the retail price of some top-selling patented pharmaceutical medications and their generic equivalents. Drug Condition Patent Price (per unit) Generic Price Estimated Manufacture Cost Markup Source Insulin (Humalog) Diabetes $300 $30 $3 10,000% Rand (2021) EpiPen Allergic reactions $600 $30 $10 6,000% BMJ (2022) Daraprim Toxoplasmosis $750/pill $2 $0.50 150,000% JAMA (2019) Harvoni Hepatitis C $94,500 (12 weeks) $30,000 $200 47,000% WHO Report (2018) Lipitor Cholesterol $150 $10 $0.50 29,900% Health Affairs (2020) Xarelto Blood Thinner $450 $25 $1.50 30,000% NEJM (2020) Abilify Schizophrenia $800 (30 tablets) $15 $2 39,900% AJMC (2019) Revlimid Cancer $16,000/mo $450 $150 10,500% Kaiser Health News (2021) Humira Arthritis $2,984/dose $400 $50 5,868% Rand (2021) Sovaldi Hepatitis C $1,000/pill $10 $2 49,900% JAMA (2021) Xolair Asthma $2,400/dose $300 $50 4,800% NEJM (2020) Gleevec Leukemia $10,000/mo $350 $200 4,900% Harvard Public Health Review (2020) OxyContin Pain Relief $600 (30 tablets) $15 $0.50 119,900% BMJ (2022) Remdesivir Covid-19 $3,120 (5 doses) N/A $10 31,100% The Lancet (2020) The corruption extends far beyond price gouging. Many pharmaceutical companies convince federal health agencies to fund their basic research and drug development with taxpayer dollars. Yet when these companies bring successful products to market, the profits are kept entirely by the corporations or shared with the agencies or groups of government scientists. On the other hand, the public, who funded the research, receives no financial return. This amounts to a systemic betrayal of the public trust on a scale of hundreds of billions of dollars annually. Another significant contributor to rising healthcare costs is the widespread practice of defensive medicine that is driven by the constant threat of litigation. Over the past 40 years, defensive medicine has become a cottage industry. Physicians order excessive diagnostic tests and unnecessary treatments simply to protect themselves from lawsuits. Study after study has shown that these over-performed procedures not only inflate costs but lead to iatrogenesis or medical injury and death caused by the medical  system and practices itself. The solution is simple: adopting no-fault healthcare coverage for everyone where patients receive care without needing to sue and thereby freeing doctors from the burden of excessive malpractice insurance. A single-payer universal healthcare system could fundamentally transform the entire industry by capping profits at every level — from drug manufacturers to hospitals to medical equipment suppliers. The Department of Health and Human Services would have the authority to set profit margins for medical procedures. This would ensure that healthcare is determined by outcomes, not profits. Additionally, the growing influence of private equity firms and vulture capitalists buying up hospitals and medical clinics across America must be reined in. These equity firms prioritize profit extraction over improving the quality of care. They often slash staff, raise prices, and dictate medical procedures based on what will yield the highest returns. Another vital reform would be to provide free medical education for doctors and nurses in exchange for five years of service under the universal system. Medical professionals would earn a realistic salary cap to prevent them from being lured into equity partnerships or charging exorbitant rates. The biggest single expense in the current system, however, is the private health insurance industry, which consumes 33 percent of the $5 trillion healthcare budget. Health insurance CEOs consistently rank among the highest-paid executives in the country. Their companies, who are nothing more than bean counters, decide what procedures and drugs will be covered, partially covered, or denied altogether. This entire industry is designed to place profits above patients' lives. If the US dismantled its existing insurance-based system and replaced it with a fully reformed national healthcare model, the country could save $2.7 trillion annually while simultaneously improving health outcomes. Over the course of 10 years, those savings would amount to $27 trillion. This could wipe out nearly the entire national debt in a short time. This solution has been available for decades but has been systematically blocked by corporate lobbying and bipartisan corruption in Washington. The path forward is clear but only if American citizens demand a system where healthcare is valued as a public service and not a commodity. The national healthcare crisis is not just a fiscal issue. It is a crucial moral failure of the highest order. With the right reforms, the nation could simultaneously restore its financial health and deliver the kind of healthcare system its citizens have long deserved. American Healthcare: Corrupt, Broken and Lethal Richard Gale and Gary Null Progressive Radio Network, March 3, 2025 For a nation that prides itself on being the world's wealthiest, most innovative and technologically advanced, the US' healthcare system is nothing less than a disaster and disgrace. Not only are Americans the least healthy among the most developed nations, but the US' health system ranks dead last among high-income countries. Despite rising costs and our unshakeable faith in American medical exceptionalism, average life expectancy in the US has remained lower than other OECD nations for many years and continues to decline. The United Nations recognizes healthcare as a human right. In 2018, former UN Secretary General Ban Ki-moon denounced the American healthcare system as "politically and morally wrong." During the pandemic it is estimated that two to three years was lost on average life expectancy. On the other hand, before the Covid-19 pandemic, countries with universal healthcare coverage found their average life expectancy stable or slowly increasing. The fundamental problem in the U.S. is that politics have been far too beholden to the pharmaceutical, HMO and private insurance industries. Neither party has made any concerted effort to reign in the corruption of corporate campaign funding and do what is sensible, financially feasible and morally correct to improve Americans' quality of health and well-being.   The fact that our healthcare system is horribly broken is proof that moneyed interests have become so powerful to keep single-payer debate out of the media spotlight and censored. Poll after poll shows that the American public favors the expansion of public health coverage. Other incremental proposals, including Medicare and Medicaid buy-in plans, are also widely preferred to the Affordable Care Act or Obamacare mess we are currently stuck with.   It is not difficult to understand how the dismal state of American medicine is the result of a system that has been sold out to the free-market and the bottom line interests of drug makers and an inflated private insurance industry. How advanced and ethically sound can a healthcare system be if tens of millions of people have no access to medical care because it is financially out of their reach?  The figures speak for themselves. The U.S. is burdened with a $41 trillion Medicare liability. The number of uninsured has declined during the past several years but still lingers around 25 million. An additional 30-35 million are underinsured. There are currently 65 million Medicare enrollees and 89 million Medicaid recipients. This is an extremely unhealthy snapshot of the country's ability to provide affordable healthcare and it is certainly unsustainable. The system is a public economic failure, benefiting no one except the large and increasingly consolidated insurance and pharmaceutical firms at the top that supervise the racket.   Our political parties have wrestled with single-payer or universal healthcare for decades. Obama ran his first 2008 presidential campaign on a single-payer platform. Since 1985, his campaign health adviser, the late Dr. Quentin Young from the University of Illinois Medical School, was one of the nation's leading voices calling for universal health coverage.  During a private conversation with Dr. Young shortly before his passing in 2016, he conveyed his sense of betrayal at the hands of the Obama administration. Dr. Young was in his 80s when he joined the Obama campaign team to help lead the young Senator to victory on a promise that America would finally catch up with other nations. The doctor sounded defeated. He shared how he was manipulated, and that Obama held no sincere intention to make universal healthcare a part of his administration's agenda. During the closed-door negotiations, which spawned the weak and compromised Affordable Care Act, Dr. Young was neither consulted nor invited to participate. In fact, he told us that he never heard from Obama again after his White House victory.   Past efforts to even raise the issue have been viciously attacked. A huge army of private interests is determined to keep the public enslaved to private insurers and high medical costs. The failure of our healthcare is in no small measure due to it being a fully for-profit operation. Last year, private health insurance accounted for 65 percent of coverage. Consider that there are over 900 private insurance companies in the US. National Health Expenditures (NHE) grew to $4.5 trillion in 2022, which was 17.3 percent of GDP. Older corporate rank-and-file Democrats and Republicans argue that a single-payer or socialized medical program is unaffordable. However, not only is single-payer affordable, it will end bankruptcies due to unpayable medical debt. In addition, universal healthcare, structured on a preventative model, will reduce disease rates at the outset.    Corporate Democrats argue that Obama's Affordable Care Act (ACA) was a positive step inching the country towards complete public coverage. However, aside from providing coverage to the poorest of Americans, Obamacare turned into another financial anchor around the necks of millions more. According to the health policy research group KFF, the average annual health insurance premium for single coverage is $8,400 and almost $24,000 for a family. In addition, patient out-of-pocket costs continue to increase, a 6.6% increase to $471 billion in 2022. Rather than healthcare spending falling, it has exploded, and the Trump and Biden administrations made matters worse.    Clearly, a universal healthcare program will require flipping the script on the entire private insurance industry, which employed over half a million people last year.  Obviously, the most volatile debate concerning a national universal healthcare system concerns cost. Although there is already a socialized healthcare system in place -- every federal legislator, bureaucrat, government employee and veteran benefits from it -- fiscal Republican conservatives and groups such as the Koch Brothers network are single-mindedly dedicated to preventing the expansion of Medicare and Medicaid. A Koch-funded Mercatus analysis made the outrageous claim that a single-payer system would increase federal health spending by $32 trillion in ten years. However, analyses and reviews by the Congressional Budget Office in the early 1990s concluded that such a system would only increase spending at the start; enormous savings would quickly offset it as the years pass. In one analysis, "the savings in administrative costs [10 percent of health spending] would be more than enough to offset the expense of universal coverage."    Defenders of those advocating for funding a National Health Program argue this can primarily be accomplished by raising taxes to levels comparable to other developed nations. This was a platform Senator Bernie Sanders and some of the younger progressive Democrats in the House campaigned on. The strategy was to tax the highest multimillion-dollar earners 60-70 percent. Despite the outrage of its critics, including old rank-and-file multi-millionaire Democrats like Nancy Pelosi and Chuck Schumer, this is still far less than in the past. During the Korean War, the top tax rate was 91 percent; it declined to 70 percent in the late 1960s. Throughout most of the 1970s, those in the lowest income bracket were taxed at 14 percent. We are not advocating for this strategy because it ignores where the funding is going, and the corruption in the system that is contributing to exorbitant waste.    But Democratic supporters of the ACA who oppose a universal healthcare plan ignore the additional taxes Obama levied to pay for the program. These included surtaxes on investment income, Medicare taxes from those earning over $200,000, taxes on tanning services, an excise tax on medical equipment, and a 40 percent tax on health coverage for costs over the designated cap that applied to flexible savings and health savings accounts. The entire ACA was reckless, sloppy and unnecessarily complicated from the start.    The fact that Obamacare further strengthened the distinctions between two parallel systems -- federal and private -- with entirely different economic structures created a labyrinth of red tape, rules, and wasteful bureaucracy. Since the ACA went into effect, over 150 new boards, agencies and programs have had to be established to monitor its 2,700 pages of gibberish. A federal single-payer system would easily eliminate this bureaucracy and waste.    A medical New Deal to establish universal healthcare coverage is a decisive step in the correct direction. But we must look at the crisis holistically and in a systematic way. Simply shuffling private insurance into a federal Medicare-for-all or buy-in program, funded by taxing the wealthiest of citizens, would only temporarily reduce costs. It will neither curtail nor slash escalating disease rates e. Any effective healthcare reform must also tackle the underlying reasons for Americans' poor state of health. We cannot shy away from examining the social illnesses infecting our entire free-market capitalist culture and its addiction to deregulation. A viable healthcare model would have to structurally transform how the medical economy operates. Finally, a successful medical New Deal must honestly evaluate the best and most reliable scientific evidence in order to effectively redirect public health spending.    For example, Dr. Ezekiel Emanuel, a former Obama healthcare adviser, observed that AIDS-HIV measures consume the most public health spending, even though the disease "ranked 75th on the list of diseases by personal health expenditures." On the other hand, according to the American Medical Association, a large percentage of the nation's $3.4 trillion healthcare spending goes towards treating preventable diseases, notably diabetes, common forms of heart disease, and back and neck pain conditions. In 2016, these three conditions were the most costly and accounted for approximately $277 billion in spending. Last year, the CDC announced the autism rate is now 1 in 36 children compared to 1 in 44 two years ago. A retracted study by Mark Blaxill, an autism activist at the Holland Center and a friend of the authors, estimates that ASD costs will reach $589 billion annually by 2030. There are no signs that this alarming trend will reverse and decline; and yet, our entire federal health system has failed to conscientiously investigate the underlying causes of this epidemic. All explanations that might interfere with the pharmaceutical industry's unchecked growth, such as over-vaccination, are ignored and viciously discredited without any sound scientific evidence. Therefore, a proper medical New Deal will require a systemic overhaul and reform of our federal health agencies, especially the HHS, CDC and FDA. Only the Robert Kennedy Jr presidential campaign is even addressing the crisis and has an inexpensive and comprehensive plan to deal with it. For any medical revolution to succeed in advancing universal healthcare, the plan must prioritize spending in a manner that serves public health and not private interests. It will also require reshuffling private corporate interests and their lobbyists to the sidelines, away from any strategic planning, in order to break up the private interests' control over federal agencies and its revolving door policies. Aside from those who benefit from this medical corruption, the overwhelming majority of Americans would agree with this criticism. However, there is a complete lack of national trust that our legislators, including the so-called progressives, would be willing to undertake such actions.    In addition, America's healthcare system ignores the single most critical initiative to reduce costs - that is, preventative efforts and programs instead of deregulation and closing loopholes designed to protect the drug and insurance industries' bottom line. Prevention can begin with banning toxic chemicals that are proven health hazards associated with current disease epidemics, and it can begin by removing a 1,000-plus toxins already banned in Europe. This should be a no-brainer for any legislator who cares for public health. For example, Stacy Malkan, co-founder of the Campaign for Safe Cosmetics, notes that "the policy approach in the US and Europe is dramatically different" when it comes to chemical allowances in cosmetic products. Whereas the EU has banned 1,328 toxic substances from the cosmetic industry alone, the US has banned only 11. The US continues to allow carcinogenic formaldehyde, petroleum, forever chemicals, many parabens (an estrogen mimicker and endocrine hormone destroyer), the highly allergenic p-phenylenediamine or PBD, triclosan, which has been associated with the rise in antibiotic resistant bacteria, avobenzone, and many others to be used in cosmetics, sunscreens, shampoo and hair dyes.   Next, the food Americans consume can be reevaluated for its health benefits. There should be no hesitation to tax the unhealthiest foods, such as commercial junk food, sodas and candy relying on high fructose corn syrup, products that contain ingredients proven to be toxic, and meat products laden with dangerous chemicals including growth hormones and antibiotics. The scientific evidence that the average American diet is contributing to rising disease trends is indisputable. We could also implement additional taxes on the public advertising of these demonstrably unhealthy products. All such tax revenue would accrue to a national universal health program to offset medical expenditures associated with the very illnesses linked to these products. Although such tax measures would help pay for a new medical New Deal, it may be combined with programs to educate the public about healthy nutrition if it is to produce a reduction in the most common preventable diseases. In fact, comprehensive nutrition courses in medical schools should be mandatory because the average physician receives no education in this crucial subject.  In addition, preventative health education should be mandatory throughout public school systems.   Private insurers force hospitals, clinics and private physicians into financial corners, and this is contributing to prodigious waste in money and resources. Annually, healthcare spending towards medical liability insurance costs tens of billions of dollars. In particular, this economic burden has taxed small clinics and physicians. It is well past the time that physician liability insurance is replaced with no-fault options. Today's doctors are spending an inordinate amount of money to protect themselves. Legions of liability and trial lawyers seek big paydays for themselves stemming from physician error. This has created a culture of fear among doctors and hospitals, resulting in the overly cautious practice of defensive medicine, driving up costs and insurance premiums just to avoid lawsuits. Doctors are forced to order unnecessary tests and prescribe more medications and medical procedures just to cover their backsides. No-fault insurance is a common-sense plan that enables physicians to pursue their profession in a manner that will reduce iatrogenic injuries and costs. Individual cases requiring additional medical intervention and loss of income would still be compensated. This would generate huge savings.    No other nation suffers from the scourge of excessive drug price gouging like the US. After many years of haggling to lower prices and increase access to generic drugs, only a minute amount of progress has been made in recent years. A 60 Minutes feature about the Affordable Care Act reported an "orgy of lobbying and backroom deals in which just about everyone with a stake in the $3-trillion-a-year health industry came out ahead—except the taxpayers.” For example, Life Extension magazine reported that an antiviral cream (acyclovir), which had lost its patent protection, "was being sold to pharmacies for 7,500% over the active ingredient cost. The active ingredient (acyclovir) costs only 8 pennies, yet pharmacies are paying a generic maker $600 for this drug and selling it to consumers for around $700." Other examples include the antibiotic Doxycycline. The price per pill averages 7 cents to $3.36 but has a 5,300 percent markup when it reaches the consumer. The antidepressant Clomipramine is marked up 3,780 percent, and the anti-hypertensive drug Captopril's mark-up is 2,850 percent. And these are generic drugs!    Medication costs need to be dramatically cut to allow drug manufacturers a reasonable but not obscene profit margin. By capping profits approximately 100 percent above all costs, we would save our system hundreds of billions of dollars. Such a measure would also extirpate the growing corporate misdemeanors of pricing fraud, which forces patients to pay out-of-pocket in order to make up for the costs insurers are unwilling to pay.    Finally, we can acknowledge that our healthcare is fundamentally a despotic rationing system based upon high insurance costs vis-a-vis a toss of the dice to determine where a person sits on the economic ladder. For the past three decades it has contributed to inequality. The present insurance-based economic metrics cast millions of Americans out of coverage because private insurance costs are beyond their means. Uwe Reinhardt, a Princeton University political economist, has called our system "brutal" because it "rations [people] out of the system." He defined rationing as "withholding something from someone that is beneficial." Discriminatory healthcare rationing now affects upwards to 60 million people who have been either priced out of the system or under insured. They make too much to qualify for Medicare under Obamacare, yet earn far too little to afford private insurance costs and premiums. In the final analysis, the entire system is discriminatory and predatory.    However, we must be realistic. Almost every member of Congress has benefited from Big Pharma and private insurance lobbyists. The only way to begin to bring our healthcare program up to the level of a truly developed nation is to remove the drug industry's rampant and unnecessary profiteering from the equation.     How did Fauci memory-hole a cure for AIDS and get away with it?   By Helen Buyniski   Over 700,000 Americans have died of AIDS since 1981, with the disease claiming some 42.3 million victims worldwide. While an HIV diagnosis is no longer considered a certain death sentence, the disease looms large in the public imagination and in public health funding, with contemporary treatments running into thousands of dollars per patient annually.   But was there a cure for AIDS all this time - an affordable and safe treatment that was ruthlessly suppressed and attacked by the US public health bureaucracy and its agents? Could this have saved millions of lives and billions of dollars spent on AZT, ddI and failed HIV vaccine trials? What could possibly justify the decision to disappear a safe and effective approach down the memory hole?   The inventor of the cure, Gary Null, already had several decades of experience creating healing protocols for physicians to help patients not responding well to conventional treatments by the time AIDS was officially defined in 1981. Null, a registered dietitian and board-certified nutritionist with a PhD in human nutrition and public health science, was a senior research fellow and Director of Anti-Aging Medicine at the Institute of Applied Biology for 36 years and has published over 950 papers, conducting groundbreaking experiments in reversing biological aging as confirmed with DNA methylation testing. Additionally, Null is a multi-award-winning documentary filmmaker, bestselling author, and investigative journalist whose work exposing crimes against humanity over the last 50 years has highlighted abuses by Big Pharma, the military-industrial complex, the financial industry, and the permanent government stay-behind networks that have come to be known as the Deep State.   Null was contacted in 1974 by Dr. Stephen Caiazza, a physician working with a subculture of gay men in New York living the so-called “fast track” lifestyle, an extreme manifestation of the gay liberation movement that began with the Stonewall riots. Defined by rampant sexual promiscuity and copious use of illegal and prescription drugs, including heavy antibiotic use for a cornucopia of sexually-transmitted diseases, the fast-track never included more than about two percent of gay men, though these dominated many of the bathhouses and clubs that defined gay nightlife in the era. These patients had become seriously ill as a result of their indulgence, generally arriving at the clinic with multiple STDs including cytomegalovirus and several types of herpes and hepatitis, along with candida overgrowth, nutritional deficiencies, gut issues, and recurring pneumonia. Every week for the next 10 years, Null would counsel two or three of these men - a total of 800 patients - on how to detoxify their bodies and de-stress their lives, tracking their progress with Caiazza and the other providers at weekly feedback meetings that he credits with allowing the team to quickly evaluate which treatments were most effective. He observed that it only took about two years on the “fast track” for a healthy young person to begin seeing muscle loss and the recurrent, lingering opportunistic infections that would later come to be associated with AIDS - while those willing to commit to a healthier lifestyle could regain their health in about a year.    It was with this background that Null established the Tri-State Healing Center in Manhattan in 1980, staffing the facility with what would eventually run to 22 certified health professionals to offer safe, natural, and effective low- and no-cost treatments to thousands of patients with HIV and AIDS-defining conditions. Null and his staff used variations of the protocols he had perfected with Caiazza's patients, a multifactorial patient-tailored approach that included high-dose vitamin C drips, intravenous ozone therapy, juicing and nutritional improvements and supplementation, aspects of homeopathy and naturopathy with some Traditional Chinese Medicine and Ayurvedic practices. Additional services offered on-site included acupuncture and holistic dentistry, while peer support groups were also held at the facility so that patients could find community and a positive environment, healing their minds and spirits while they healed their bodies.   “Instead of trying to kill the virus with antiretroviral pharmaceuticals designed to stop viral replication before it kills patients, we focused on what benefits could be gained by building up the patients' natural immunity and restoring biochemical integrity so the body could fight for itself,” Null wrote in a 2014 article describing the philosophy behind the Center's approach, which was wholly at odds with the pharmaceutical model.1   Patients were comprehensively tested every week, with any “recovery” defined solely by the labs, which documented AIDS patient after patient - 1,200 of them - returning to good health and reversing their debilitating conditions. Null claims to have never lost an AIDS patient in the Center's care, even as the death toll for the disease - and its pharmaceutical standard of care AZT - reached an all-time high in the early 1990s. Eight patients who had opted for a more intensive course of treatment - visiting the Center six days a week rather than one - actually sero-deconverted, with repeated subsequent testing showing no trace of HIV in their bodies.   As an experienced clinical researcher himself, Null recognized that any claims made by the Center would be massively scrutinized, challenging as they did the prevailing scientific consensus that AIDS was an incurable, terminal illness. He freely gave his protocols to any medical practitioner who asked, understanding that his own work could be considered scientifically valid only if others could replicate it under the same conditions. After weeks of daily observational visits to the Center, Dr. Robert Cathcart took the protocols back to San Francisco, where he excitedly reported that patients were no longer dying in his care.    Null's own colleague at the Institute of Applied Biology, senior research fellow Elana Avram, set up IV drip rooms at the Institute and used his intensive protocols to sero-deconvert 10 patients over a two-year period. While the experiment had been conducted in secret, as the Institute had been funded by Big Pharma since its inception half a century earlier, Avram had hoped she would be able to publish a journal article to further publicize Null's protocols and potentially help AIDS patients, who were still dying at incredibly high rates thanks to Burroughs Wellcome's noxious but profitable AZT. But as she would later explain in a 2019 letter to Null, their groundbreaking research never made it into print - despite meticulous documentation of their successes - because the Institute's director and board feared their pharmaceutical benefactors would withdraw the funding on which they depended, given that Null's protocols did not involve any patentable or otherwise profitable drugs. When Avram approached them about publication, the board vetoed the idea, arguing that it would “draw negative attention because [the work] was contrary to standard drug treatments.” With no real point in continuing experiments along those lines without institutional support and no hope of obtaining funding from elsewhere, the department she had created specifically for these experiments shut down after a two-year followup with her test subjects - all of whom remained alive and healthy - was completed.2   While the Center was receiving regular visits by this time from medical professionals and, increasingly, black celebrities like Stokely Carmichael and Isaac Hayes, who would occasionally perform for the patients, the news was spreading by word of mouth alone - not a single media outlet had dared to document the clinic that was curing AIDS patients for free. Instead, they gave airtime to Anthony Fauci, director of the National Institute of Allergies and Infectious Diseases, who had for years been spreading baseless, hysteria-fueling claims about HIV and AIDS to any news outlet that would put him on. His claim that children could contract the virus from “ordinary household conduct” with an infected relative proved so outrageous he had to walk it back,3 and he never really stopped insisting the deadly plague associated with gays and drug users was about to explode like a nuclear bomb among the law-abiding heterosexual population. Fauci by this time controlled all government science funding through NIAID, and his zero-tolerance approach to dissent on the HIV/AIDS front had already seen prominent scientists like virologist Peter Duesberg stripped of the resources they needed for their work because they had dared to question his commandment: There is no cause of AIDS but HIV, and AZT is its treatment. Even the AIDS activist groups, which by then had been coopted by Big Pharma and essentially reduced to astroturfing for the toxic failed chemotherapy drug AZT backed by the institutional might of Fauci's NIAID,4 didn't seem to want to hear that there was a cure. Unconcerned with the irrationality of denouncing the man touting his free AIDS cure as an  “AIDS denier,” they warned journalists that platforming Null or anyone else rejecting the mainstream medical line would be met with organized demands for their firing.    Determined to breach the institutional iron curtain and get his message to the masses, Null and his team staged a press conference in New York, inviting scientists and doctors from around the world to share their research on alternative approaches to HIV and AIDS in 1993. To emphasize the sound scientific basis of the Center's protocols and encourage guests to adopt them into their own practices, Null printed out thousands of abstracts in support of each nutrient and treatment being used. However, despite over 7,000 invitations sent three times to major media, government figures, scientists, and activists, almost none of the intended audience members showed up. Over 100 AIDS patients and their doctors, whose charts exhaustively documented their improvements using natural and nontoxic modalities over the preceding 12 months, gave filmed testimonials, declaring that the feared disease was no longer a death sentence, but the conference had effectively been silenced. Bill Tatum, publisher of the Amsterdam News, suggested Null and his patients would find a more welcoming audience in his home neighborhood of Harlem - specifically, its iconic Apollo Theatre. For three nights, the theater was packed to capacity. Hit especially hard by the epidemic and distrustful of a medical system that had only recently stopped being openly racist (the Tuskegee syphilis experiment only ended in 1972), black Americans, at least, did not seem to care what Anthony Fauci would do if he found out they were investigating alternatives to AZT and death.    PBS journalist Tony Brown, having obtained a copy of the video of patient testimonials from the failed press conference, was among a handful of black journalists who began visiting the Center to investigate the legitimacy of Null's claims. Satisfied they had something significant to offer his audience, Brown invited eight patients - along with Null himself - onto his program over the course of several episodes to discuss the work. It was the first time these protocols had received any attention in the media, despite Null having released nearly two dozen articles and multiple documentaries on the subject by that time. A typical patient on one program, Al, a recovered IV drug user who was diagnosed with AIDS at age 32, described how he “panicked,” saw a doctor and started taking AZT despite his misgivings - only to be forced to discontinue the drug after just a few weeks due to his condition deteriorating rapidly. Researching alternatives brought him to Null, and after six months of “detoxing [his] lifestyle,” he observed his initial symptoms - swollen lymph nodes and weight loss - begin to reverse, culminating with sero-deconversion. On Bill McCreary's Channel 5 program, a married couple diagnosed with HIV described how they watched their T-cell counts increase as they cut out sugar, caffeine, smoking, and drinking and began eating a healthy diet. They also saw the virus leave their bodies.   For HIV-positive viewers surrounded by fear and negativity, watching healthy-looking, cheerful “AIDS patients” detail their recovery while Null backed up their claims with charts must have been balm for the soul. But the TV programs were also a form of outreach to the medical community, with patients' charts always on hand to convince skeptics the cure was scientifically valid. Null brought patients' charts to every program, urging them to keep an open mind: “Other physicians and public health officials should know that there's good science in the alternative perspective. It may not be a therapy that they're familiar with, because they're just not trained in it, but if the results are positive, and you can document them…” He challenged doubters to send in charts from their own sero-deconverted patients on AZT, and volunteered to debate proponents of the orthodox treatment paradigm - though the NIH and WHO both refused to participate in such a debate on Tony Brown's Journal, following Fauci's directive prohibiting engagement with forbidden ideas.    Aside from those few TV programs and Null's own films, suppression of Null's AIDS cure beyond word of mouth was total. The 2021 documentary The Cost of Denial, produced by the Society for Independent Journalists, tells the story of the Tri-State Healing Center and the medical paradigm that sought to destroy it, lamenting the loss of the lives that might have been saved in a more enlightened society. Nurse practitioner Luanne Pennesi, who treated many of the AIDS patients at the Center, speculated in the film that the refusal by the scientific establishment and AIDS activists to accept their successes was financially motivated. “It was as if they didn't want this information to get out. Understand that our healthcare system as we know it is a corporation, it's a corporate model, and it's about generating revenue. My concern was that maybe they couldn't generate enough revenue from these natural approaches.”5   Funding was certainly the main disciplinary tool Fauci's NIAID used to keep the scientific community in line. Despite the massive community interest in the work being done at the Center, no foundation or institution would defy Fauci and risk getting itself blacklisted, leaving Null to continue funding the operation out of his pocket with the profits from book sales. After 15 years, he left the Center in 1995, convinced the mainstream model had so thoroughly been institutionalized that there was no chance of overthrowing it. He has continued to counsel patients and advocate for a reappraisal of the HIV=AIDS hypothesis and its pharmaceutical treatments, highlighting the deeply flawed science underpinning the model of the disease espoused by the scientific establishment in 39 articles, six documentaries and a 700-page textbook on AIDS, but the Center's achievements have been effectively memory-holed by Fauci's multi-billion-dollar propaganda apparatus.     FRUIT OF THE POISONOUS TREE   To understand just how much of a threat Null's work was to the HIV/AIDS establishment, it is instructive to revisit the 1984 paper, published by Dr. Robert Gallo of the National Cancer Institute, that established HIV as the sole cause of AIDS. The CDC's official recognition of AIDS in 1981 had done little to quell the mounting public panic over the mysterious illness afflicting gay men in the US, as the agency had effectively admitted it had no idea what was causing them to sicken and die. As years passed with no progress determining the causative agent of the plague, activist groups like Gay Men's Health Crisis disrupted public events and threatened further mass civil disobedience as they excoriated the NIH for its sluggish allocation of government science funding to uncovering the cause of the “gay cancer.”6 When Gallo published his paper declaring that the retrovirus we now know as HIV was the sole “probable” cause of AIDS, its simple, single-factor hypothesis was the answer to the scientific establishment's prayers. This was particularly true for Fauci, as the NIAID chief was able to claim the hot new disease as his agency's own domain in what has been described as a “dramatic confrontation” with his rival Sam Broder at the National Cancer Institute. After all, Fauci pointed out, Gallo's findings - presented by Health and Human Services Secretary Margaret Heckler as if they were gospel truth before any other scientists had had a chance to inspect them, never mind conduct a full peer review - clearly classified AIDS as an infectious disease, and not a cancer like the Kaposi's sarcoma which was at the time its most visible manifestation. Money and media attention began pouring in, even as funding for the investigation of other potential causes of AIDS dried up. Having already patented a diagnostic test for “his” retrovirus before introducing it to the world, Gallo was poised for a financial windfall, while Fauci was busily leveraging the discovery into full bureaucratic empire of the US scientific apparatus.   While it would serve as the sole basis for all US government-backed AIDS research to follow - quickly turning Gallo into the most-cited scientist in the world during the 1980s,7 Gallo's “discovery” of HIV was deeply problematic. The sample that yielded the momentous discovery actually belonged to Prof. Luc Montagnier of the French Institut Pasteur, a fact Gallo finally admitted in 1991, four years after a lawsuit from the French government challenged his patent on the HIV antibody test, forcing the US government to negotiate a hasty profit-sharing agreement between Gallo's and Montagnier's labs. That lawsuit triggered a cascade of official investigations into scientific misconduct by Gallo, and evidence submitted during one of these probes, unearthed in 2008 by journalist Janine Roberts, revealed a much deeper problem with the seminal “discovery.” While Gallo's co-author, Mikulas Popovic, had concluded after numerous experiments with the French samples that the virus they contained was not the cause of AIDS, Gallo had drastically altered the paper's conclusion, scribbling his notes in the margins, and submitted it for publication to the journal Science without informing his co-author.   After Roberts shared her discovery with contacts in the scientific community, 37 scientific experts wrote to the journal demanding that Gallo's career-defining HIV paper be retracted from Science for lacking scientific integrity.8 Their call, backed by an endorsement from the 2,600-member scientific organization Rethinking AIDS, was ignored by the publication and by the rest of mainstream science despite - or perhaps because of - its profound implications.   That 2008 letter, addressed to Science editor-in-chief Bruce Alberts and copied to American Association for the Advancement of Science CEO Alan Leshner, is worth reproducing here in its entirety, as it utterly dismantles Gallo's hypothesis - and with them the entire HIV is the sole cause of AIDS dogma upon which the contemporary medical model of the disease rests:   On May 4, 1984 your journal published four papers by a group led by Dr. Robert Gallo. We are writing to express our serious concerns with regard to the integrity and veracity of the lead paper among these four of which Dr. Mikulas Popovic is the lead author.[1] The other three are also of concern because they rely upon the conclusions of the lead paper .[2][3][4]  In the early 1990s, several highly critical reports on the research underlying these papers were produced as a result of governmental inquiries working under the supervision of scientists nominated by the National Academy of Sciences and the Institute of Medicine. The Office of Research Integrity of the US Department of Health and Human Services concluded that the lead paper was “fraught with false and erroneous statements,” and that the “ORI believes that the careless and unacceptable keeping of research records...reflects irresponsible laboratory management that has permanently impaired the ability to retrace the important steps taken.”[5] Further, a Congressional Subcommittee on Oversight and Investigations led by US Representative John D. Dingell of Michigan produced a staff report on the papers which contains scathing criticisms of their integrity.[6]  Despite the publically available record of challenges to their veracity, these papers have remained uncorrected and continue to be part of the scientific record.  What prompts our communication today is the recent revelation of an astonishing number of previously unreported deletions and unjustified alterations made by Gallo to the lead paper. There are several documents originating from Gallo's laboratory that, while available for some time, have only recently been fully analyzed. These include a draft of the lead paper typewritten by Popovic which contains handwritten changes made to it by Gallo.[7] This draft was the key evidence used in the above described inquiries to establish that Gallo had concealed his laboratory's use of a cell culture sample (known as LAV) which it received from the Institut Pasteur.  These earlier inquiries verified that the typed manuscript draft was produced by Popovic who had carried out the recorded experiment while his laboratory chief, Gallo, was in Europe and that, upon his return, Gallo changed the document by hand a few days before it was submitted to Science on March 30, 1984. According to the ORI investigation, “Dr. Gallo systematically rewrote the manuscript for what would become a renowned LTCB [Gallo's laboratory at the National Cancer Institute] paper.”[5]  This document provided the important evidence that established the basis for awarding Dr. Luc Montagnier and Dr. Francoise Barré-Sinoussi the 2008 Nobel Prize in Medicine for the discovery of the AIDS virus by proving it was their samples of LAV that Popovic used in his key experiment. The draft reveals that Popovic had forthrightly admitted using the French samples of LAV renamed as Gallo's virus, HTLV-III, and that Gallo had deleted this admission, concealing their use of LAV.  However, it has not been previously reported that on page three of this same document Gallo had also deleted Popovic's unambiguous statement that, "Despite intensive research efforts, the causative agent of AIDS has not yet been identified,” replacing it in the published paper with a statement that said practically the opposite, namely, “That a retrovirus of the HTLV family might be an etiologic agent of AIDS was suggested by the findings.”  It is clear that the rest of Popovic's typed paper is entirely consistent with his statement that the cause of AIDS had not been found, despite his use of the French LAV. Popovic's final conclusion was that the culture he produced “provides the possibility” for detailed studies. He claimed to have achieved nothing more. At no point in his paper did Popovic attempt to prove that any virus caused AIDS, and it is evident that Gallo concealed these key elements in Popovic's experimental findings.  It is astonishing now to discover these unreported changes to such a seminal document. We can only assume that Gallo's alterations of Popovic's conclusions were not highlighted by earlier inquiries because the focus at the time was on establishing that the sample used by Gallo's lab came from Montagnier and was not independently collected by Gallo. In fact, the only attention paid to the deletions made by Gallo pertains to his effort to hide the identity of the sample. The questions of whether Gallo and Popovic's research proved that LAV or any other virus was the cause of AIDS were clearly not considered.  Related to these questions are other long overlooked documents that merit your attention. One of these is a letter from Dr. Matthew A. Gonda, then Head of the Electron Microscopy Laboratory at the National Cancer Institute, which is addressed to Popovic, copied to Gallo and dated just four days prior to Gallo's submission to Science.[8] In this letter, Gonda remarks on samples he had been sent for imaging because “Dr Gallo wanted these micrographs for publication because they contain HTLV.” He states, “I do not believe any of the particles photographed are of HTLV-I, II or III.” According to Gonda, one sample contained cellular debris, while another had no particles near the size of a retrovirus. Despite Gonda's clearly worded statement, Science published on May 4, 1984 papers attributed to Gallo et al with micrographs attributed to Gonda and described unequivocally as HTLV-III.  In another letter by Gallo, dated one day before he submitted his papers to Science, Gallo states, “It's extremely rare to find fresh cells [from AIDS patients] expressing the virus... cell culture seems to be necessary to induce virus,” a statement which raises the possibility he was working with a laboratory artifact. [9]  Included here are copies of these documents and links to the same. The very serious flaws they reveal in the preparation of the lead paper published in your journal in 1984 prompts our request that this paper be withdrawn. It appears that key experimental findings have been concealed. We further request that the three associated papers published on the same date also be withdrawn as they depend on the accuracy of this paper.  For the scientific record to be reliable, it is vital that papers shown to be flawed, or falsified be retracted. Because a very public record now exists showing that the Gallo papers drew unjustified conclusions, their withdrawal from Science is all the more important to maintain integrity. Future researchers must also understand they cannot rely on the 1984 Gallo papers for statements about HIV and AIDS, and all authors of papers that previously relied on this set of four papers should have the opportunity to consider whether their own conclusions are weakened by these revelations.      Gallo's handwritten revision, submitted without his colleague's knowledge despite multiple experiments that failed to support the new conclusion, was the sole foundation for the HIV=AIDS hypothesis. Had Science published the manuscript the way Popovic had typed it, there would be no AIDS “pandemic” - merely small clusters of people with AIDS. Without a viral hypothesis backing the development of expensive and deadly pharmaceuticals, would Fauci have allowed these patients to learn about the cure that existed all along?   Faced with a potential rebellion, Fauci marshaled the full resources under his control to squelch the publication of the investigations into Gallo and restrict any discussion of competing hypotheses in the scientific and mainstream press, which had been running virus-scare stories full-time since 1984. The effect was total, according to biochemist Dr. Kary Mullis, inventor of the polymerase chain reaction (PCR) procedure. In a 2009 interview, Mullis recalled his own shock when he attempted to unearth the experimental basis for the HIV=AIDS hypothesis. Despite his extensive inquiry into the literature, “there wasn't a scientific reference…[that] said ‘here's how come we know that HIV is the probable cause of AIDS.' There was nothing out there like that.”9 This yawning void at the core of HIV/AIDS “science" turned him into a strident critic of AIDS dogma - and those views made him persona non grata where the scientific press was concerned, suddenly unable to publish a single paper despite having won the Nobel Prize for his invention of the PCR test just weeks before.  10   DISSENT BECOMES “DENIAL”   While many of those who dissent from the orthodox HIV=AIDS view believe HIV plays a role in the development of AIDS, they point to lifestyle and other co-factors as being equally if not more important. Individuals who test positive for HIV can live for decades in perfect health - so long as they don't take AZT or the other toxic antivirals fast-tracked by Fauci's NIAID - but those who developed full-blown AIDS generally engaged in highly risky behaviors like extreme promiscuity and prodigious drug abuse, contracting STDs they took large quantities of antibiotics to treat, further running down their immune systems. While AIDS was largely portrayed as a “gay disease,” it was only the “fast track” gays, hooking up with dozens of partners nightly in sex marathons fueled by “poppers” (nitrate inhalants notorious for their own devastating effects on the immune system), who became sick. Kaposi's sarcoma, one of the original AIDS-defining conditions, was widespread among poppers-using gay men, but never appeared among IV drug users or hemophiliacs, the other two main risk groups during the early years of the epidemic. Even Robert Gallo himself, at a 1994 conference on poppers held by the National Institute on Drug Abuse, would admit that the previously-rare form of skin cancer surging among gay men was not primarily caused by HIV - and that it was immune stimulation, rather than suppression, that was likely responsible.11 Similarly, IV drug users are often riddled with opportunistic infections as their habit depresses the immune system and their focus on maintaining their addiction means that healthier habits - like good nutrition and even basic hygiene - fall by the wayside.    Supporting the call for revising the HIV=AIDS hypothesis to include co-factors is the fact that the mass heterosexual outbreaks long predicted by Fauci and his ilk in seemingly every country on Earth have failed to materialize, except - supposedly - in Africa, where the diagnostic standard for AIDS differs dramatically from those of the West. Given the prohibitively high cost of HIV testing for poor African nations, the WHO in 1985 crafted a diagnostic loophole that became known as the “Bangui definition,” allowing medical professionals to diagnose AIDS in the absence of a test using just clinical symptoms: high fever, persistent cough, at least 30 days of diarrhea, and the loss of 10% of one's body weight within two months. Often suffering from malnutrition and without access to clean drinking water, many of the inhabitants of sub-Saharan Africa fit the bill, especially when the WHO added tuberculosis to the list of AIDS-defining illnesses in 1993 - a move which may be responsible for as many as one half of African “AIDS” cases, according to journalist Christine Johnson. The WHO's former Chief of Global HIV Surveillance, James Chin, acknowledged their manipulation of statistics, but stressed that it was the entire AIDS industry - not just his organization - perpetrating the fraud. “There's the saying that, if you knew what sausages are made of, most people would hesitate to sort of eat them, because they wouldn't like what's in it. And if you knew how HIV/AIDS numbers are cooked, or made up, you would use them with extreme caution,” Chin told an interviewer in 2009.12   With infected numbers stubbornly remaining constant in the US despite Fauci's fearmongering projections of the looming heterosexually-transmitted plague, the CDC in 1993 broadened its definition of AIDS to include asymptomatic (that is, healthy) HIV-positive people with low T-cell counts - an absurd criteria given that an individual's T-cell count can fluctuate by hundreds within a single day. As a result, the number of “AIDS cases” in the US immediately doubled. Supervised by Fauci, the NIAID had been quietly piling on diseases into the “AIDS-related” category for years, bloating the list from just two conditions - pneumocystis carinii pneumonia and Kaposi's sarcoma - to 30 so fast it raised eyebrows among some of science's leading lights. Deeming the entire process “bizarre” and unprecedented, Kary Mullis wondered aloud why no one had called the AIDS establishment out: “There's something wrong here. And it's got to be financial.”13   Indeed, an early CDC public relations campaign was exposed by the Wall Street Journal in 1987 as having deliberately mischaracterized AIDS as a threat to the entire population so as to garner increased public and private funding for what was very much a niche issue, with the risk to average heterosexuals from a single act of sex “smaller than the risk of ever getting hit by lightning.” Ironically, the ads, which sought to humanize AIDS patients in an era when few Americans knew anyone with the disease and more than half the adult population thought infected people should be forced to carry cards warning of their status, could be seen as a reaction to the fear tactics deployed by Fauci early on.14   It's hard to tell where fraud ends and incompetence begins with Gallo's HIV antibody test. Much like Covid-19 would become a “pandemic of testing,” with murder victims and motorcycle crashes lumped into “Covid deaths” thanks to over-sensitized PCR tests that yielded as many as 90% false positives,15 HIV testing is fraught with false positives - and unlike with Covid-19, most people who hear they are HIV-positive still believe they are receiving a death sentence. Due to the difficulty of isolating HIV itself from human samples, the most common diagnostic tests, ELISA and the Western Blot, are designed to detect not the virus but antibodies to it, upending the traditional medical understanding that the presence of antibodies indicates only exposure - and often that the body has actually vanquished the pathogen. Patients are known to test positive for HIV antibodies in the absence of the virus due to at least 70 other conditions, including hepatitis, lupus, rheumatoid arthritis, syphilis, recent vaccination or even pregnancy. (https://www.chcfl.org/diseases-that-can-cause-a-false-positive-hiv-test/) Positive results are often followed up with a PCR “viral load” test, even though the inventor of the PCR technique Kary Mullis famously condemned its misuse as a tool for diagnosing infection. Packaging inserts for all three tests warn the user that they cannot be reliably used to diagnose HIV.16 The ELISA HIV antibody test explicitly states: “At present there is no recognized standard for establishing the presence and absence of HIV antibody in human blood.”17   That the public remains largely unaware of these and other massive holes in the supposedly airtight HIV=AIDS=DEATH paradigm is a testament to Fauci's multi-layered control of the press. Like the writers of the Great Barrington Declaration and other Covid-19 dissidents, scientists who question HIV/AIDS dogma have been brutally punished for their heresy, no matter how prestigious their prior standing in the field and no matter how much evidence they have for their own claims. In 1987, the year the FDA's approval of AZT made AIDS the most profitable epidemic yet (a dubious designation Covid-19 has since surpassed), Fauci made it clearer than ever that scientific inquiry and debate - the basis of the scientific method - would no longer be welcome in the American public health sector, eliminating retrovirologist Peter Duesberg, then one of the most prominent opponents of the HIV=AIDS hypothesis, from the scientific conversation with a professional disemboweling that would make a cartel hitman blush. Duesberg had just eviscerated Gallo's 1984 HIV paper with an article of his own in the journal Cancer Research, pointing out that retroviruses had never before been found to cause a single disease in humans - let alone 30 AIDS-defining diseases. Rather than allow Gallo or any of the other scientists in his camp to respond to the challenge, Fauci waged a scorched-earth campaign against Duesberg, who had until then been one of the most highly regarded researchers in his field. Every research grant he requested was denied; every media appearance was canceled or preempted. The University of California at Berkeley, unable to fully fire him due to tenure, took away his lab, his graduate students, and the rest of his funding. The few colleagues who dared speak up for him in public were also attacked, while enemies and opportunists were encouraged to slander Duesberg at the conferences he was barred from attending and in the journals that would no longer publish his replies. When Duesberg was summoned to the White House later that year by then-President Ronald Reagan to debate Fauci on the origins of AIDS, Fauci convinced the president to cancel, allegedly pulling rank on the Commander-in-Chief with an accusation that the “White House was interfering in scientific matters that belonged to the NIH and the Office of Science and Technology Assessment.” After seven years of this treatment, Duesberg was contacted by NIH official Stephen O'Brien and offered an escape from professional purgatory. He could have “everything back,” he was told, and shown a manuscript of a scientific paper - apparently commissioned by the editor of the journal Nature - “HIV Causes AIDS: Koch's Postulates Fulfilled” with his own name listed alongside O'Brien's as an author.18 His refusal to take the bribe effectively guaranteed the epithet “AIDS denier” will appear on his tombstone. The character assassination of Duesberg became a template that would be deployed to great effectiveness wherever Fauci encountered dissent - never debate, only demonize, deplatform and destroy.    Even Luc Montagnier, the real discoverer of HIV, soon found himself on the wrong side of the Fauci machine. With his 1990 declaration that “the HIV virus [by itself] is harmless and passive, a benign virus,” Montagnier began distancing himself from Gallo's fraud, effectively placing a target on his own back. In a 1995 interview, he elaborated: “four factors that have come together to account for the sudden epidemic [of AIDS]: HIV presence, immune hyper-activation, increased sexually transmitted disease incidence, sexual behavior changes and other behavioral changes” such as drug use, poor nutrition and stress - all of which he said had to occur “essentially simultaneously” for HIV to be transmitted, creating the modern epidemic. Like the professionals at the Tri-State Healing Center, Montagnier advocated for the use of antioxidants like vitamin C and N-acetyl cysteine, naming oxidative stress as a critical factor in the progression from HIV to AIDS.19 When Montagnier died in 2022, Fauci's media mouthpieces sneered that the scientist (who was awarded the Nobel Prize in 2008 for his discovery of HIV, despite his flagging faith in that discovery's significance) “started espousing views devoid of a scientific basis” in the late 2000s, leading him to be “shunned by the scientific community.”20 In a particularly egregious jab, the Washington Post's obit sings the praises of Robert Gallo, implying it was the American scientist who really should have won the Nobel for HIV, while dismissing as “

In this episode, I had the privilege of speaking with John Ioannidis, a renowned scientist and meta-researcher whose groundbreaking work has shaped our understanding of scientific reliability and its societal implications. We dive into his influential 2005 paper, Why Most Published Research Findings Are False, explore the evolution of scientific challenges over the past two decades, and reflect on how science intersects with policy and public trust—especially in times of crisis like COVID-19. We begin with John taking us back to 2005, when he published his paper in PLOS Medicine. He explains how it emerged from decades of empirical evidence on biases and false positives in research, considering factors like study size, statistical power, and competition that can distort findings, and why building on shaky foundations wastes time and resources. “It was one effort to try to put together some possibilities, of calculating what are the chances that once we think we have come up with a scientific discovery with some statistical inference suggesting that we have a statistically significant result, how likely is that not to be so?” I propose a distinction between “honest” and “dishonest” scientific failures, and John refines this. What does failure really mean, and how can they be categorised? The discussion turns to the rise of fraud, with John revealing a startling shift: while fraud once required artistry, today's “paper mills” churn out fake studies at scale. We touch on cases like Jan-Hendrik Schön, who published prolifically in top journals before being exposed, and how modern hyper-productivity, such as a paper every five days, raises red flags yet often goes unchecked. “Perhaps an estimate for what is going on now is that it accounts for about 10%, not just 1%, because we have new ways of massive… outright fraud.” This leads to a broader question about science's efficiency. When we observe scientific output—papers, funding—grows exponentially but does breakthroughs lag? John is cautiously optimistic, acknowledging progress, but agrees efficiency isn't what it could be. We reference Max Perutz's recipe for success: “No politics, no committees, no reports, no referees, no interviews; just gifted, highly motivated people, picked by a few men of good judgement.” Could this be replicated in today's world or are we stuck in red tape? “It is true that the progress is not proportional to the massive increase in some of the other numbers.” We then pivot to nutrition, a field John describes as “messy.” How is it possible that with millions of papers, results are mosty based on shaky correlations rather than solid causal evidence? What are the reasons for this situation and what consequences does it have, e.g. in people trusting scientific results? “Most of these recommendations are built on thin air. They have no solid science behind them.” The pandemic looms large next. In 2020 Nassim Taleb and John Ioannidis had a dispute about the measures to be taken. What happened in March 2020 and onwards? Did we as society show paranoid overreactions, fuelled by clueless editorials and media hype? “I gave interviews where I said, that's fine. We don't know what we're facing with. It is okay to start with some very aggressive measures, but what we need is reliable evidence to be obtained as quickly as possible.” Was the medicine, metaphorically speaking, worse than the disease? How can society balance worst-case scenarios without paralysis. “We managed to kill far more by doing what we did.” Who is framing the public narrative of complex questions like climate change or a pandemic? Is it really science driven, based on the best knowledge we have? In recent years influential scientific magazines publish articles by staff writers that have a high impact on the public perception, but are not necessarily well grounded: “They know everything before we know anything.” The conversation grows personal as John shares the toll of the COVID era—death threats to him and his family—and mourns the loss of civil debate. He'd rather hear from critics than echo chambers, but the partisan “war” mindset drowned out reason. Can science recover its humility and openness? “I think very little of that happened. There was no willingness to see opponents as anything but enemies in a war.” Inspired by Gerd Gigerenzer, who will be a guest in this show very soon, we close on the pitfalls of hyper-complex models in science and policy. How can we handle decision making under radical uncertainty? Which type of models help, which can lead us astray? “I'm worried that complexity sometimes could be an alibi for confusion.” This conversation left me both inspired and unsettled. John's clarity on science's flaws, paired with his hope for reform, offers a roadmap, but the stakes are high. From nutrition to pandemics, shaky science shapes our lives, and rebuilding trust demands we embrace uncertainty, not dogma. His call for dialogue over destruction is a plea we should not ignore. Other Episodes Episode 116: Science and Politics, A Conversation with Prof. Jessica Weinkle Episode 112: Nullius in Verba — oder: Der Müll der Wissenschaft Episode 109: Was ist Komplexität? Ein Gespräch mit Dr. Marco Wehr Episode 107: How to Organise Complex Societies? A Conversation with Johan Norberg Episode 106: Wissenschaft als Ersatzreligion? Ein Gespräch mit  Manfred Glauninger Episode 103: Schwarze Schwäne in Extremistan; die Welt des Nassim Taleb, ein Gespräch mit Ralph Zlabinger Episode 94: Systemisches Denken und gesellschaftliche Verwundbarkeit, ein Gespräch mit Herbert Saurugg Episode 92: Wissen und Expertise Teil 2 Episode 90: Unintended Consequences (Unerwartete Folgen) Episode 86: Climate Uncertainty and Risk, a conversation with Dr. Judith Curry Episode 67: Wissenschaft, Hype und Realität — ein Gespräch mit Stephan Schleim References Prof. John Ioannidis at Stanford University  John P. A. Ioannidis, Why Most Published Research Findings Are False, PLOS Medicine (2005) John Ioannidis, A fiasco in the making? As the coronavirus pandemic takes hold, weare making decisions without reliable data (2020) John Ioannidis, The scientists who publish a paper every five days, Nature Comment (2018) Hanae Armitage, 5 Questions: John Ioannidis calls for more rigorous nutrition research (2018) John Ioannidis, How the Pandemic Is Changing Scientific Norms, Tablet Magazine (2021) John Ioannidis et al, Uncertainty and Inconsistency of COVID-19 Non-Pharmaceutical1Intervention Effects with Multiple Competitive Statistical Models (2025) John Ioannidis et al, Forecasting for COVID-19 has failed (2022) Gerd Gigerenzer, Transparent modeling of influenza incidence: Big data or asingle data point from psychological theory? (2022) Sabine Kleinert, Richard Horton, How should medical science change? Lancet Comment (2014) Max Perutz quotation taken from Geoffrey West, Scale, Weidenfeld & Nicolson (2017) John Ioannidis: Das Gewissen der Wissenschaft, Ö1 Dimensionen (2024)  

Una ricerca pubblicata sulla rivista Plos Medicine ha evidenziato che gli adulti con una storia di depressione si ammalano di patologie fisiche circa il 30% più velocemente di chi non ne soffre. A Obiettivo Salute il commento del prof Claudio Mencacci, direttore emerito di psichiatria all’ospedale Fatebenefratelli di Milano e co-presidente Sinpf.

C dans l'air du 7 février 2025 - Cancer : ces aliments qui nous empoisonnentNous en consommons parfois sans même le savoir. L'aspartame, cet édulcorant artificiel, utilisé comme substitut au sucre dans l'industrie agroalimentaire, présent dans plus de 2500 produits en Europe, y compris dans ceux qui ne sont pas sucrés, comme les plats préparés ou encore les dentifrices destinés aux enfants mais aussi plus de 600 médicaments, est depuis plusieurs jours au centre des débats. À l'occasion de la journée mondiale contre le cancer le 4 février, l'ONG Foodwatch, l'association française de Ligue contre le cancer et l'application Yuka ont lancé une pétition pour réclamer son interdiction invoquant "le principe de précaution" dans le cas d'un produit classé dans la catégorie des "cancérogènes possibles" par l'Organisation mondiale de la santé (OMS). En Europe, il est désigné par le sigle E 951 sur l'étiquette de vos produits, le "9" désignant la famille des édulcorants. Les signataires de la pétition basent notamment leur argumentaire sur une étude de l'Institut national de la santé et de la recherche médicale (Inserm) parue il y a trois ans dans la revue PLOS Medicine selon laquelle la consommation d'aspartame augmenterait les risques de cancers, de maladies cardiovasculaires et de diabète de type 2. Pour les trois co-créateurs de la pétition, il s'agit d'un enjeu de "santé publique" et, afin d'éviter les risques pour les consommateurs.Mais qu'est-ce que l'aspartame ? Est-ce dangereux pour la santé ? Comment le repérer dans les aliments et les boissons ? Au-delà de cet édulcorant, quel est l'impact de ce que nous mangeons et buvons sur notre santé ? Et quelle eau faut-il boire ? Plusieurs enquêtes et études récentes interrogent sur la qualité de l'eau, en bouteille ou du robinet.Deux campagnes distinctes menées par le laboratoire Eurofins et les associations UFC-Que choisir et Générations futures ont ainsi révélé en janvier dernier que l'eau potable dans l'Hexagone seraient massivement contaminée par des polluants éternels, notamment le TFA (acide trifluoroacétique), issu de la dégradation de pesticides fluorés et d'autres composés industriels. Les taux observés restent néanmoins en dessous des seuils règlementaires en France, moins stricte que ceux d'autres pays, comme le Danemark ou les Etats-Unis. Et ces derniers jours un rapport de la Commission européenne pointe "une situation très préoccupante" en France, avec presque un tiers des eaux souterraines du pays polluées par les pesticides et les nitrates.Parallèlement, une étude menée par des scientifiques toulousains portant sur dix marques de bouteille d'eau vendues en grande surface a montré il y a peu qu'elles contenaient des micro plastiques. Et une enquête de la cellule Investigation de Radio France a relancé cette semaine l'affaire de la fraude aux eaux minérales du groupe Nestlé.Alors que faut–il en penser ? Faut-il s'inquiéter pour notre santé ? Quels sont les bons choix de consommation ? Et pourquoi les cancers sont-ils en forte augmentation, notamment chez les plus jeunes ? Le nombre de malades de moins de 50 ans a presque doublé en 30 ans.Les experts :- KARINE JACQUEMART - Directrice Générale chez foodwatch France - NICOLAS BERROD - Journaliste au Parisien-Aujourd'hui en France au service Futurs, santé-médecine et climat- JEAN-EMMANUEL BIBAULT - Médecin-chercheur spécialisé en oncologie à l'Hôpital européen Georges-Pompidou - LUCE JEAN-BAPTISTE - Diététicienne à l'Hôpital Pitié Salpêtrière

The Grains & Legumes Nutrition Council's Whole Grain Week is coming soon (next week!). We're bringing you Elissa Price, PhD Candidate at the University of New South Wales to discuss her research findings on ultra-processed foods (UPF) and whole grains. We cover: What is food processing? Why are foods processed? Is it always bad? What is an UPF? The latest evidence on UPFs and healthRegardless of how whole grains are processed, what does the research tell us about whole grains and health? Can UPFs be part of a healthy diet? Elissa's three key takeaways on UPFs and whole grainsOne-liners you don't want to miss:“They categorise foods based on the level of processing and that UPF is that more extreme group of processing. They define an UPF based on the nature, extent and purpose of the food processing and are identified foods that have gone through more extensive processing.”“Higher ultra-processed food intake and worse health outcomes. Some of those being obesity, cancer, type 2 diabetes, cardiovascular disease, irritable bowel syndrome, depression and all-cause mortality. There is a lot of research happening in this space and a lot of links being made.”References Whole-grain health benefits Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2019. 393(10184): p. 1958-1972.UPF health associations Taneri, P.E., et al., Association Between Ultra-Processed Food İntake and All-Cause Mortality: A Systematic Review and Meta-Analysis. Am J Epidemiol, 2022.Martínez Steele, E., et al., Dietary share of ultra-processed foods and metabolic syndrome in the US adult population. Preventive Medicine, 2019. 125: p. 40-48.Lane, M.M., et al., Higher Ultra-Processed Food Consumption Is Associated with Greater High-Sensitivity C-Reactive Protein Concentration in Adults: Cross-Sectional Results from the Melbourne Collaborative Cohort Study. Nutrients, 2022. 14(16): p. 3309.Beslay, M., et al., Ultra-processed food intake in association with BMI change and risk of overweight and obesity: A prospective analysis of the French NutriNet-Santé cohort. PLOS Medicine, 2020. 17(8): p. e1003256.Nova UPF subgroup associations Mendoza, K., et al., Ultra-processed foods and cardiovascular disease: analysis of three large US prospective cohorts and a systematic review and meta-analysis of prospective cohort studies. The Lancet Regional Health – Americas, 2024. 37.Chen, Z., et al., Ultra-Processed Food Consumption and Risk of Type 2 Diabetes: Three Large Prospective U.S. Cohort Studies. Diabetes Care, 2023. 46(7): p. 1335-1344.Cordova, R., et al., Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study. The Lancet Regional Health – Europe.Nova UPF whole-grain exclusion Price, E.J., et al., Excluding whole grain-containing foods from the Nova ultraprocessed food category: a cross-sectional analysis of the impact on associations with cardiometabolic risk measures. Am J Clin Nutr, 2024.Nova and ADG discordance Nguyen, H., et al., Extent of alignment between the Australian Dietary Guidelines and the NOVA classification system across the Australian packaged food supply. Nutr Diet, 2024.

Kennedy Dunn and Rasheed Thompson, 4th year medical students at Howard U define our roots, being uprooted and what it means to be human in the 7th and final episode of Stranger Fruit Vol. II   Time Stamps:  0:00 Empowering Minority Medical Professionals & Exploring Identity 5:07 Insights on Medical Practice & Building Trust with Patients 11:37 Reflections on Love, Faith, and Growth in Medicine 19:41 Navigating Personal and Professional Development 32:49 Importance of Empathy, Relationships, and Identity in Healthcare   References: Holt, M., Piro, J., & Brown, S. (2015). The impact of bullying and harassment on victims' mental health: A meta-analysis. Journal of Behavioral Health, 6(4), 287-304. Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7(7), e1000316. https://doi.org/10.1371/journal.pmed.1000316 Patchin, J. W., & Hinduja, S. (2020). Cyberbullying: An updated review of the literature. Journal of Adolescent Health, 66(6), 711-718. https://doi.org/10.1016/j.jadohealth.2020.01.016 Ttofi, M. M., Farrington, D. P., Lösel, F., & Loeber, R. (2011). The predictive efficacy of peer victimization for later mental health problems: A meta-analysis. Journal of Aggression, Conflict and Peace Research, 3(4), 185-196. https://doi.org/10.1108/17596591111182373 Uchino, B. N. (2006). Social support and physical health: Understanding the health consequences of relationships. Yale University Press. Intro Music: Bosch's Garden - by Kjartan Abel. This work is licensed under the following: CC BY-SA 4.0 Attribution-ShareAlike 4.0 International.

There are an awful lot of things to worry about in the world. Are “superbugs” among them? That is, how worried should we be that bacteria will develop resistance to our best antibiotics, meaning infections will run rampant and even basic surgery is out of the question?In this episode of The Studies Show, Tom and Stuart wash their hands and then dig in to the evidence on the coming antimicrobial crisis. Exactly how many deaths can we expect from untreatable resistant infections? Turns out the question is, ahem, resistant to easy answers. (Sorry).The Studies Show is brought to you by Works in Progress magazine. Every issue, every article, gives you a new perspective on a topic you thought you knew about, or a totally new topic to think about. In their most recent issue, you can read about inflation, ancient scrolls and AI, genetic engineering, and the evolution of coffee. We're grateful that they support the podcast; you can read their whole site for free at worksinprogress.co.Show notes* Andreas Bäumler on “the coming microbial crisis”* Possible source for how many people used to die in surgery * BMJ article on the evidence (or lack of) showing that completing an antibiotic course is necessary* Satirical post on how the length of a course is calculated* Our World In Data on how many people die from cancer each year* UK Government review of antimicrobial resistance (from 2014), giving the 10m figure. * More mentions of 10m here (NHS), and here (Guardian)* 2016 paper in PLOS Medicine criticising the modelling that led to the 10m figure* September 2024 paper in the Lancet with a more up-to-date calculation* EU report on how MRSA rates dropped* Article on the wildly successful UK attempt to cut MRSA infections* Study on how many antibiotics are in the clinical “pipeline”* Thread on studies showing that using antibiotics prophylactically cut child mortality in sub-Sarahan Africa by 14%Credits* The Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

Die Themen in den Wissensnachrichten: +++ Kurze Wege vor allem in europäischen Städten +++ Algorithmus sagt, welche Kommune für Geflüchtete am besten passt +++ Pub-Versuch: Kleinere Gläser = weniger Alkoholkonsum +++**********Weiterführende Quellen zu dieser Folge:A universal framework for inclusive 15-minute cities, Nature, 16.9. 2024Algorithmus hilft dabei, Schutzsuchende besser auf Kommunen zu verteilen, FAU, 17.9. 2024Impact on beer sales of removing the pint serving size: An A-B-A reversal trial in pubs, bars, and restaurants in England, PLOS MEDICINE, 17.9. 2024Novel rebreathing adaptation extends dive time in a semi-aquatic lizard, Biology Letters, 18.9. 2024Scheduling meetings: are the odds in your favor?, The European Physical Journal B, 13.8. 2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

Freunde sind die Familie, die man sich aussuchen kann. Grund genug, um zu feiern! Gut, dass es den internationalen Tag der Freundschaft (30.07.) gibt, den eure beiden Podcast-Palaberer ausgiebig zelebrieren. Dabei besprechen Jannis und Luca in Folge 16 von locker und logisch unter anderem, warum es wichtig ist Freunde im Leben zu haben und worauf Männer und Frauen besonders Wert in einer guten Freundschaft legen. Literatur Hall, J. A. (2018). How many hours does it take to make a friend? Journal Of Social And Personal Relationships, 36(4), 1278–1296. https://doi.org/10.1177/0265407518761225 Holt-Lunstad, J., Smith, T. B. & Layton, J. B. (2010). Social Relationships and Mortality Risk: A Meta-analytic Review. PLoS Medicine, 7(7), e1000316. https://doi.org/10.1371/journal.pmed.1000316 Lewis, D. M., Conroy-Beam, D., Al-Shawaf, L., Raja, A., DeKay, T. & Buss, D. M. (2011). Friends with Benefits: The Evolved Psychology of Same- and Opposite-Sex Friendship. Evolutionary Psychology, 9(4), 543–563. https://doi.org/10.1177/147470491100900407  Waldinger, R. J. & Schulz, M. S. (2010). What's love got to do with it? Social functioning, perceived health, and daily happiness in married octogenarians. Psychology And Aging, 25(2), 422–431. https://doi.org/10.1037/a0019087

Welcome to episode ⁠⁠#108 of the MindCep Podcast! In this episode of MindCep, we explore evidence-based strategies to enhance your daily life and long-term well-being. Learn about the five best things you can do to improve your life, backed by scientific research. From the importance of quality sleep to the benefits of lifelong learning, this episode provides actionable tips to help you lead a more fulfilling life. Key Topics Covered The crucial role of quality sleep in overall well-being How mindfulness meditation can reduce stress and anxiety The physical and mental benefits of regular exercise The importance of strong social connections for health and happiness Why pursuing lifelong learning contributes to a sense of purpose and achievement Actionable Takeaways Establish a consistent sleep schedule aiming for 7-9 hours per night Start a daily mindfulness meditation practice, beginning with just 5 minutes Incorporate 150 minutes of moderate-intensity exercise into your weekly routine Make an effort to maintain and strengthen your social relationships Set aside time each week for learning something new Keywords mental health, personal development, self-improvement, wellness, productivity, sleep hygiene, mindfulness, meditation, physical exercise, social connections, lifelong learning, well-being, stress reduction, healthy habits, personal growth Tags #MindCep, #PersonalDevelopment, #SelfImprovement, #MentalHealth, #Wellness, #SleepHygiene, #Mindfulness, #Exercise, #SocialConnections, #LifelongLearning, #StressReduction, #HealthyHabits, #PersonalGrowth Subscribe to MindCep for more insights on personal development and mental wellness. If you enjoyed this episode, please leave a review and share it with friends who might benefit from these life-improving strategies. Join the conversation on our social media channels and let us know which strategy you're excited to try! Resources Mentioned Walker, M. P., et al. (2019). Sleep and Human Performance. Nature, 585, 376-377. Khoury, B., et al. (2013). Mindfulness-based therapy: A comprehensive meta-analysis. Clinical Psychology Review, 33(6), 763-771. World Health Organization. (2020). Physical activity. WHO.int. Holt-Lunstad, J., et al. (2010). Social Relationships and Mortality Risk: A Meta-analytic Review. PLoS Medicine, 7(7), e1000316. Hammond, C. (2004). Impacts of lifelong learning upon emotional resilience, psychological and mental health: fieldwork evidence. Oxford Review of Education, 30(4), 551-568. If you enjoyed this episode, please leave a review, subscribe, and share it with your friends. If you enjoy the MindCep Podcast, please leave us a 5 ⭐️ review on Apple Podcasts and Spotify Podcasts. Don't forget to comment, rate, and subscribe for future content recommendations. We appreciate your support! The MindCep Mission: At MindCep, our mission is to promote optimal, mental and physical well-being for 30+ million listeners worldwide through engaging podcasts that inspire positive change for future generations. Thank you for tuning in and joining us on this journey. Cheers, Alex Connect with us: Alex's Blog & Podcast: ⁠⁠https://alexandermuir.com/blog/⁠⁠ Instagram: Alex Muir (@mind.cep) • Instagram photos and videos Youtube: ⁠⁠   / @mind-cep  ⁠⁠ Tiktok: ⁠⁠https://www.tiktok.com/@mind.cep?lang=en⁠⁠ DISCLAIMER: The information I provide to the podcast listeners of MindCep is based on my own research and personal experience. It is not intended to be a substitute for professional advice, diagnosis, or treatment. Not all information is factual or has scientific evidence to support it. I am simply sharing the best information I can find and finding valuable content to help you improve your mental health and well-being.

Send us a Text Message.Welcome to the third episode of season four of Conversations in Fetal Medicine, where we speak to Professor Jenny Myers.Professor Myers' bio:Jenny is Professor of Obstetrics & Maternal Medicine within the Maternal & Fetal Health Research Centre, University of Manchester and Consultant Obstetrician, St Mary's Hospital. As an obstetrician, Jenny is part of the Maternal Medicine team and leads two translational research clinics for women with hypertension and diabetes. She is also the Hospital Chief Clinical Informatics Officer for St Mary's Managed Clinical Service (18000 births). She currently runs a portfolio of clinical and laboratory science studies which span vascular and placental biology research, preclinical models, observational cohort studies and intervention trials before, during and after pregnancy.Jenny is the chief/principal investigator for several multicenter studies related tohypertension and diabetes in pregnancy. Jenny is a Consulting Editor for Plos Medicine,President of the RCOG Blair Bell Research Society, obstetric advisor for the NationalDiabetes in Pregnancy Audit and has served on several NICE committees.World Pre-eclampsia Day 2024:This is on May 22nd 2024. Find out more about it from APEC (Action on Pre-eclampsia) here: https://action-on-pre-eclampsia.org.uk/world-pre-eclampsia-day/Phoenix study:Find out more about the Phoenix study here: Chappell LC, Brocklehurst P, Green ME, Hunter R, Hardy P, Juszczak E, Linsell L, Chiocchia V, Greenland M, Placzek A, Townend J, Marlow N, Sandall J, Shennan A; PHOENIX Study Group. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet. 2019 Sephttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2819%2931963-4/fulltextPodcast information:We have not included any patient identifiable information, and this podcast is intended for professional education rather than patient information (although welcome anyone interested in the field to listen). Please get in touch with feedback or suggestions for future guests or topics: conversationsinfetalmed@gmail.com, or via Twitter (X) or Instagram via @fetalmedcast.Music by Crowander ('Acoustic romance') used under creative commons licence. Podcast created, hosted and edited by Dr Jane Currie.

“To live alone one must be either a beast or a god, says Aristotle. Leaving out the third case: one must be both…” Nietzsche, Twilight of the Idols According to a 2010 study published in the journal PLOS Medicine, the health risks of chronic loneliness are equivalent to smoking 15 cigarettes a day. To mitigate […] The post Why Solitude Promotes Greatness – The Benefits of Being Alone first appeared on Academy of Ideas.

Investigadores britânicos concluem que servir bebidas em copos mais pequenos ajuda a diminuir o consumo de álcool, porque as pessoas tendem a beber à unidade. Estudo publicado no Plos Medicine.

This week we discuss the chronic neurological condition Multiple Sclerosis. Samantha Joseph BA (Hons), DipBCNH, mBANT, CNHC, is a Nutritional Therapist. Her husband Danny was diagnosed with MS in 2002 which led her to specialise in this area. She has been a guest lecturer for colleges of Integrative Nutrition covering modules on MS, Parkinson's disease, mental & behavioural health. In 2018 she joined the charity Overcoming MS as a senior facilitator. Samantha also worked together with the MS Academy (www.neurologyacademy.org) giving nutritional advice for their Healthy Living Services clinics and collaborated on the a paper pending in Frontiers of Neurology, highlighting holistic management of MS, https://linktr.ee/nutritionista_uk Karen Lee, previously intensive care nurse and practising registered nutritionist, combines her love of food with her professional background to inspire others to experience the powerful effects of food as medicine.  As ‘The Sensitive Foodie', Karen has run courses, workshops and cooking classes, and has a blog – The Sensitive Foodie Kitchen. In 2019, Karen published her first book Eat Well Live Well with The Sensitive Foodie and is currently working on her second. Karen is an Ambassador for Overcoming MS and helped to create The PBHP-UK factsheet on MS. She was co-author on a case study in The American Journal of Lifestyle Medicine. She is also Events Manager for Plant-Based Health Professionals UK. Website: https://thesensitivefoodiekitchen.com Facebook: https://facebook.com/thesensitivefoodie Instagram: https://Instagram.com/the.sensitive.foodie Historical Swank Evidence:  Swank RL, Dugan BB. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet. 1990 Jul 7;336(8706):37-9. Swank, RL. MS: a correlation of its incidence with dietary fat. Am J Med Sci. 1950;220:421-30  Bjørnevik, K. Polyunsaturated fatty acids and the risk of multiple sclerosis.  Multiple Sclerosis Journal,  2017. 23(14), 1830–1838  Jelinek GA, et al. Association of fish consumption and Ω 3 supplementation with quality of life, disability and disease activity in an international cohort of people with multiple sclerosis. Int J Neurosci. 2013 Nov;123(11):792-800 Esparza ML, et al. A brief original contribution: Nutrition, Latitude, and Multiple Sclerosis Mortality: An Ecologic Study. American Journal of Epidemiology, 1995. 142(7):733–737  Simpson-Yap S, et al. Longitudinal associations between quality of diet and disability over 7.5 years in an international sample of people with multiple sclerosis. Eur J Neurol. 2023 Jul 11. doi: 10.1111/ene.15980  Ayroza Galvão Ribeiro Gomes AB, et al. Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination. JAMA Neurol. 2023 Aug 7:e232523 Agranoff BW & Goldberg D. Diet and the geographical distribution of multiple sclerosis. Lancet. 1974; 2:1061-6 Munger KL, et al. Vitamin D intake and incidence of MS. Neurology. 2004;62:60-5 Richards JB. Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study., 2015. PLoS Medicine. Aug 25;12(8):e1001866 Hadgkiss EJ et al. The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis. Nutritional Neuroscience. 2015;18(3):125-136. Fitzgerald KC, Tyry T, Salter A, Cofield SS, Cutter G, Fox R, Marrie RA. Diet quality is associated with disability and symptom severity in multiple sclerosis. Neurology. 2018 Jan 2;90(1):e1-e11. Simpson-Yap S, et al. Longitudinal associations between quality of diet and disability over 7.5 years in an international sample of people with multiple sclerosis. Eur J Neurol. 2023 Jul 11. doi: 10.1111/ene.15980 Evers I, et al. Adherence to dietary guidelines is associated with better physical and mental quality of life: results from a cross-sectional survey among 728 Dutch MS patients. Nutr Neurosci. 2022 Aug;25(8):1633-1640

Die Themen in den Wissensnachrichten: +++ Banken geben sich oft umweltbewusster als sie sind +++ Wie Sprachen klingen hängt von der Temperatur ab +++ KI ist exzellente Weinkennerin +++**********Weiterführende Quellen zu dieser Folge:Green lending: do banks walk the talk?/ The ECB-Blog, 06.12.2023Temperature shapes language sonority: Revalidation from a large dataset/ PNAS Nexus, 05.12.2023Immaterielles Kulturerbe/ Queichwiesen, 05.12.2023Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial/ PLOS Medicine, 05.12.2023Widespread evidence for elephant exploitation by Last Interglacial Neanderthals on the North European plain/ PNAS, 04.12.2023Predicting Bordeaux red wine origins and vintages from raw gas chromatograms/ Communication Chemistry, 05.12.2023**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

Geoff Cumming is an Emeritus Professor at La Trobe University. In this conversation, we discuss his work on New Statistics: estimation instead of hypothesis testing, meta-analytic thinking, and many related topics.Support the show: https://geni.us/bjks-patreonTimestamps0:00:00: A brief history of statistics, p-values, and confidence intervals0:32:02: Meta-analytic thinking0:42:56: Why do p-values seem so random?0:45:59: Are p-values and estimation complementary?0:47:09: How do I know how many participants I need (without a power calculation)?0:50:27: Problems of the estimation approach (big data)1:00:08: A book or paper more people should read1:02:50: Something Geoff wishes he'd learnt sooner1:04:52: Advice for PhD students and postdocsPodcast linksWebsite: https://geni.us/bjks-podTwitter: https://geni.us/bjks-pod-twtGeoff's linksWebsite: https://geni.us/cumming-webGoogle Scholar: https://geni.us/cumming-scholarMastodon: https://nerdculture.de/@thenewstatsBen's linksWebsite: https://geni.us/bjks-webGoogle Scholar: https://geni.us/bjks-scholarTwitter: https://geni.us/bjks-twtReferences/linksDance of the p-values: https://www.youtube.com/watch?v=5OL1RqHrZQ8Significance roulette: https://www.youtube.com/watch?v=OcJImS16jR4Episode with Simine Vazire (SIPS): https://geni.us/bjks-vazireCoulson, ...(2010). Confidence intervals permit, but don't guarantee, better inference than statistical significance testing. Front in Psychol.Cumming & Calin-Jageman (2016/2024). Introduction to the new statistics: Estimation, open science, and beyond.Cumming (2014). The new statistics: Why and how. Psychol Sci.Cumming & Finch (2005). Inference by eye: confidence intervals and how to read pictures of data. American Psychol.Errington, ... (2021) Reproducibility in Cancer Biology: Challpenges for assessing replicability in preclinical cancer biology. eLife.Errington, ... (2021) Investigating the replicability of preclinical cancer biology. eLife.Finch & Cumming (2009). Putting research in context: Understanding confidence intervals from one or more studies. J of Pediatric Psychol.Hedges (1987). How hard is hard science, how soft is soft science? The empirical cumulativeness of research. American Psychologist.Hunt (1997). How science takes stock: The story of meta-analysis.Ioannidis (2005). Why most published research findings are false. PLoS Medicine.Loftus (1996). Psychology will be a much better science when we change the way we analyze data. Curr direct psychol sci.Maxwell, ... (2008). Sample size planning for statistical power and accuracy in parameter estimation. Annu Rev Psychol.Oakes (1986). Statistical inference: A commentary for the social and behavioural sciences.Pennington (2023). A Student's Guide to Open Science: Using the Replication Crisis Reform Psychology.Rothman (1986). Significance questing. Annals of Int Med.Schmidt (1996). Statistical significance testing and cumulative knowledge in psychology: Implications for training of researchers. Psychol Methods.

Die Themen in den Wissensnachrichten: +++ Zuckersteuer auf Softdrinks +++ Geschlechterlücke in Wissenschaft schrumpft +++ Hustensaftverkäufe als Indikator +++**********Weiterführende Quellen zu dieser Folge:Projected health and economic impacts of sugar-sweetened beverage taxation in Germany: A cross-validation modelling study, Plos Medicine, 21.11.2023Gender imbalances among top-cited scientists across scientific disciplines over time through the analysis of nearly 5.8 million authors, Plos Biology, 21.11.2023Assessing the value of integrating national longitudinal shopping data into respiratory disease forecasting models, Nature Communications, 21.11.2023Experimental mining plumes and ocean warming trigger stress in a deep pelagic jellyfish, Nature Communications, 21.11.2023Potential drivers of the recent large Antarctic ozone holes, Nature Communications, 21.11.2023A large-scale comparison of human-written versus ChatGPT-generated essays, Scientific Reports, 30.10.2023**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

The pandemic had many lingering side effects. One of those is loneliness. A little-known fact is that loneliness has such far-reaching consequences that the health impact is comparable to smoking up to 15 cigarettes a day, according to one study published in the journal PLOS Medicine. Loneliness, coupled with increasing obesity and its detrimental effects on health are making it hard to make solid improvements in Iowa's overall health.  With 37% of our population characterized as obese, employers, especially manufacturers who require more arduous physical demands must step alongside their employees to solve the problem. Full show details are at https://iowapodcast.com/jami-haberl-manufacturing                           *** You just got a free box of teeth whitening strips from Brady Dental Care! Sign up as a new patient to get your free kit. https://bradydentalcare.com/hello

Weltweit werden 780 Mio. Menschen bis 2045 an Diabetes mellitus erkranken. 2021 waren ca. 10% der Weltbevölkerung zwischen 20-79 Jahren von Diabetes mellitus betroffen. (IDF 2022) Deswegen schauen wir uns heute einmal genauer an: Was ist Diabetes mellitus genau? Wodurch zeichnet sich Typ 2 aus? Hat meine Ernährung Einfluss auf mein Erkrankungsrisiko? Welche Ernährungsmuster können das das Risiko erhöhen bzw. senken? Kann eine pflanzliche Ernährung die Diabetestherapie unterstützen? 0:50 Wie viele Menschen sind an Diabetes mellitus erkrankt? 2:06 Was ist Diabetes mellitus Typ 2 überhaupt? 5:00 Welche Risikofaktoren gibt es? 6:58 Hat meine Ernährung Einfluss auf mein Erkrankungsrisiko? 10:01 Welche Lebensmittel senken/erhöhen mein Erkrankungsrisiko? 12:40 Welchen Einfluss hat eine pflanzliche Ernährung in der Diabetestherapie? 14:57 Wieso ist eine frühzeitige Diagnose und Behandlung wichtig? 15:58 Fazit Quellen: -- 0:50 / 1:06 Tönnies T, Rathmann W, Hoyer A, Brinks R, Kuss O. Quantifying the underestimation of projected global diabetes prevalence by the International Diabetes Federation (IDF) Diabetes Atlas. BMJ Open Diabetes Res Care. 2021 Aug;9(1):e002122. doi: 10.1136/bmjdrc-2021-002122. -- 1:18 Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. (2018): IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 138, 271– 281. -- 2:55 eigene Darstellung -- 8:13 Leitzmann C, Keller M (2020): Vegetarische und vegane Ernährung. Ulmer, Stuttgart. 4. Aufl., S. 130 -- 9:11 Papier K, Appleby PN, Fensom GK, Knuppel A, Perez-Cornago A, Schmidt JA, Tong TYN, Key TJ. Vegetarian diets and risk of hospitalisation or death with diabetes in British adults: results from the EPIC-Oxford study. Nutr Diabetes. 2019 Feb 25;9(1):7. doi: 10.1038/s41387-019-0074-0. PMID: 30804320; PMCID: PMC6389979. -- 10:01 / 10:26 Satija A, Bhupathiraju SN, Rimm EB, Spiegelman D, Chiuve SE, et al. (2016) Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLOS Medicine 13(6): e1002039. https://doi.org/10.1371/journal.pmed.1002039 -- 12:41 eigene Darstellung nach Landgraf R, Aberle J, Birkenfeld AL, Gallwitz B, Kellerer M, Klein HH, Müller-Wieland D, Nauck MA, Reuter HM, Siegel E (2020): Praxisempfehlungen der Deutschen Diabetes Gesellschaft. Online unter: https://www.deutsche-diabetes-gesellschaft.de/fileadmin/user_upload/05_Behandlung/01_Leitlinien/Praxisempfehlungen/2020/dus_2020_S01_Praxisempfehlungen_Therapie-Typ-2-Diabetes_Landgraf.pdf (abgerufen 10.06.22) -- 13:52 Viguiliouk E, Kendall CW, Kahleová H, Rahelić D, Salas-Salvadó J, Choo VL, Mejia SB, Stewart SE, Leiter LA, Jenkins DJ, Sievenpiper JL. Effect of vegetarian dietary patterns on cardiometabolic risk factors in diabetes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2019 Jun;38(3):1133-1145. doi: 10.1016/j.clnu.2018.05.032. Epub 2018 Jun 13. PMID: 29960809. -- 15:14 Leitzmann C, Keller M (2020): Vegetarische und vegane Ernährung. Ulmer, Stuttgart. 4. Aufl., S. 128 Wenn ihr möchtet, unterstützt die Arbeit des IFPE sehr gern mit einer Spende: ⁠⁠⁠⁠⁠https://ifpe-giessen.de/index.php/spenden/⁠⁠⁠⁠⁠ Alle Informationen findet ihr auf der Homepage: ⁠⁠⁠⁠⁠https://ifpe-giessen.de/⁠⁠⁠⁠⁠ Dr. Markus Keller ist der weltweit erste Professor für vegane Ernährung: ⁠⁠⁠⁠⁠https://www.drmarkuskeller.de/⁠⁠⁠⁠⁠ Buchtipps Vegetarische und vegane Ernährung: ⁠⁠⁠⁠⁠https://amzn.to/2N42bn1⁠⁠⁠⁠⁠ (Amazon)* ⁠⁠⁠⁠⁠https://tidd.ly/3oqHe53⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠(Thalia)* (Gebraucht kaufen)* Ernährung des Menschen: ⁠⁠⁠⁠⁠https://amzn.to/2PO16BZ⁠⁠⁠⁠⁠ (Amazon)* ⁠⁠⁠⁠⁠https://tidd.ly/2XoTlDy⁠⁠⁠⁠⁠ (Thalia)* (Gebraucht kaufen)* Vegane Ernährung: Schwangerschaft, Stillzeit und Beikost: ⁠⁠⁠⁠⁠ https://amzn.to/3n4Q6OU⁠⁠⁠⁠⁠ (Amazon)* ⁠⁠⁠⁠⁠https://tidd.ly/3q4NVgh⁠⁠⁠⁠⁠ (Gebraucht kaufen)*

Hola amigos!! En este episodio vamos a hablar sobre los mejores y peores alimentos para tu salud. ¿Sabías que lo que comes puede tener un gran impacto en tu bienestar físico y mental? Algunos alimentos pueden ayudarte a prevenir enfermedades, mientras que otros pueden aumentar el riesgo de padecerlas. Por eso, en este episodio vamos a clasificar los alimentos desde los más beneficiosos hasta los menos recomendados para tu salud. Hablaremos sobre los alimentos que debes incorporar a tu dieta para mantener un estilo de vida saludable y los que debes evitar o reducir. Enlaces del episodio: International Journal of Eidemiology (2021): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687122/ Lancet (2019): https://www.thelancet.com/article/S0140-6736(19)30041-8/fulltext Nutrition Reviewa (2022): https://academic.oup.com/nutritionreviews/article/80/9/1959/6563767 Plos Medicine (2022): https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003889 Aplicación: https://priorityapp.shinyapps.io/Food/ Instagram: https://www.instagram.com/estoy.sano/ Todos mis servicios en: estoysano.com Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Back in early days of the COVID-19 pandemic, Dr. John Ioannidis wrote an article in March of 2020 questioning government statistics about the fatality rate associated with COVID-19. The backlash was swift and brutal and John's reputation as one of the most influential scientists in the world took a beating. Today, John makes his second appearance on STEM-Talk to discuss his extensive research into the COVID-19 pandemic as well as the public shaming he received in 2020 for questioning the World Health Organization's prediction of a 3.4 percent fatality rate associated with COVID-19. John also talks about his most recent peer-reviewed paper that looked at the age-stratified infection fatality rate of COVID-19 in the non-elderly population.  The study found that the pre-vaccination fatality rate for those infected may have been as low as 0.03 percent for people under 60 years old, and 0.07 percent for people under 70, far below the World Health Organization's prediction of a 3.4 percent fatality rate. In today's episode, John walks us through this paper, which was published in January, as well as what he describes as the U.S. government's bungled response to COVID-19. He also discusses the importance of collecting reliable data in the future to guide disease modelers and governments before they make decisions of monumental significance like lockdowns. He goes on to share how he underestimated the power that politics and the media, or powers outside of science, can have on science. Over the past two decades, John's research has earned him a global reputation as a consummate physician and researcher, which contributed to The Atlantic describing John in 2010 as one of the most influential scientists alive. He is a professor of Medicine, Epidemiology and Population Health as well as a statistician and professor of biomedical data science at Stanford University. Back in 2018 when we interviewed John on episode 77 of STEM-Talk, we talked to him about his 2005 paper questioning the reliability of most medical research. The paper, titled, “Why Most Published Research Findings Are False,” found that much of the medical science reported in peer-reviewed journals is flawed and cannot be replicated. The paper is the most citied article in the history of the journal PLoS Medicine and has been viewed more than 3 million times. Show notes: [00:03:16] Dawn opens the interview welcoming John back to STEM-Talk. his last appearance being in 2018. Dawn explains that when John last appeared on STEM-Talk in 2018, he was described by Atlantic Magazine as “one of the most influential scientists alive.” But in the intervening years, John became public enemy number one in 2020 after a paper he published questioning government statistics about COVID 19's fatality rate. Dawn asks John if it's fair to say that he has been on a rather rocky ride for the past few years. [00:03:54] Dawn explains that John was trained at Harvard and Tufts universities in internal medicine and infectious disease, and asks John what led him to study infectious disease. [00:04:54] Ken asks John about his initial thoughts in 2019 when he first heard the reports coming out of China about COVID-19. [00:05:52] Ken explains that in March of 2020, John fell into some hot water for writing a piece questioning the 3.4 percent fatality rate associated with COVID-19. John found this number to be inflated and wrote that while COVID-19 was indeed a threat, it did not behave like the Spanish Flu or a pandemic that would lead to a 3.4 percent fatality rate. Ken asks John how he came to this conclusion. [00:08:37] The article that John wrote in 2020 was titled “A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data.” John argued in his article that the data collected in the first three months of the pandemic was “utterly unreliable.” He went on to write that no one had a good way of knowing how many people ...

In the patchwork quilt that is America post- Roe, chemical abortion is becoming the new battleground in the states. We discuss the new laws emerging on either side of the abortion pill issue, the looming decision of a Texas federal judge on whether to suspend the FDA's approval of mifepristone, and how a group of hobby pilots are fly abortion patients out of states with bans. Plus, we discuss the new study showing hormonal birth control elevates the risk of breast cancer.  Topics Discussed:Elevated Access & the hobby pilots flying women out of state for abortionsWyoming becomes first state to ban abortion pillsCA bill seeks to protect doctors who mail abortion pills to other statesThe looming decision of a Texas federal judge on whether to suspend the FDA's approval of mifepristoneNew study shows hormonal birth control elevates the risk of breast cancerIntroducing a new segment Links Mentioned:Small Planes and Secrecy: Pilots Fly People to Kansas and Other States For Abortions - KMUW NewsWyoming Becomes First State To Ban Abortion Pills - Detroit CatholicCA Bill Would Protect Doctors Who Mail Abortion Pills To Other States - AxiosBill SB-345 Health care servicesThe Abortion Mecca - Life Dynamics BlogAbortion Pill Ruling Looms Over FDA's Drug Approval Process - AxiosAll Hormonal Contraceptives ‘Carry Small Increased Risk Of Breast Cancer' - The GuardianStudy Finds Same Small Rise In Breast Cancer Risk In Many Forms Of Hormonal Birth Control - Stat NewsCombined and Progestagen-Only Hormonal Contraceptives and Breast Cancer Risk: A UK Nested Case–Control Study and Meta-Analysis - PLOS MedicinePro-Life America Podcast Episode 41: Birth Control – What They're Not Telling YouLime 5 - By Mark CrutcherRate & Review Our Podcast Have a topic you want to see discussed on the show? [Submit it here.]To learn more about what Life Dynamics does, visit: https://lifedynamics.com/about-us/Support Our Work

In our second episode, we discuss the role of skepticism in science, a topic that relates closely to the title of our podcast. Given that the scientific enterprise is essentially an exercise in organized skepticism, how can we maintain a healthy amount of skepticism while also ensuring that scientists don't slip into cynicism or nihilism?    Shownotes Opening quote by Imre Lakatos from Science and Pseudoscience. Hear it from the man himself.  Ego depletion Ioannidis, J. P. (2005). Why most published research findings are false. PLoS Medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124 Wacholder, S., Chanock, S., Garcia-Closas, M., El Ghormli, L., & Rothman, N. (2004). Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. Journal of the National Cancer Institute, 96(6), 434-442. DOI: 10.1093/jnci/djh075 Quote by Debra Mayo. Original reference: Mayo, D. G. (2018). Statistical inference as severe testing: How to get beyond the statistics wars. Cambridge University Press.

In this episode we have two interviews about two different—but both very important—topics. In the second interview, Dr. Celestin Hategeka, from the Department of Global Health and Population, Harvard TH Chan School of Public Health, discusses his recently published systematic review in PLoS Medicine that identified several unmet needs in noncommunicable disease prevention, as well as control interventions, in low- and middle-income countries. But first, our regular contributor, Dr. MedLaw—a board-certified radiologist and medical malpractice attorney—discusses the important topic of employment contracts. As always, Dr. MedLaw serves us a fascinating twist with her insights! Enjoy listening!Additional reading:Hategeka C, Adu P, Desloge A, Marten R, Shao R, Tian M, Wei T, Kruk ME. Implementation research on noncommunicable disease prevention and control interventions in low- and middle-income countries: A systematic review. PLoS Med. 2022 Jul 25;19(7):e1004055.

Die Themen in den Wissensnachrichten: +++ Nordstream-Lecks haben wohl kaum Auswirkungen aufs Klima +++ Corona-Zahlen 2020 höher als gedacht +++ Warum Freundschaften gut für den Darm sein könnten +++ **********Weiterführende Quellen zu dieser Folge:Negligible Warming Caused by Nord Stream Methane Leaks/ Advances in Atmospheric Sciences, 11.11.22Global SARS-CoV-2 seroprevalence from January 2020 to April 2022: A systematic review and meta-analysis of standardized population-based studies/ Plos Medicine, 8.11.22Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros/ iScience, 20.10.22Global Carbon Budget 2022/ Earth System Science Data, 11.11.22NASA Views Images, Confirms Discovery of Shuttle Challenger Artifact/ Nasa, 10.11.22Sociability in a non-captive macaque population is associated with beneficial gut bacteria/ Frontiers in Microbiology, 11.11.22**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Weitere Wissensnachrichten zum Nachlesen: https://www.deutschlandfunknova.de/nachrichten

Video: Interview with Dr. Rupert Sheldrake (41:21) Stomach cancer cells halted with whole tomato extracts Sbarro Institute for Molecular Medicine at Temple University  October 10, 2022 The Mediterranean diet has become regarded as highly beneficial to overall health, maintaining ideal weight and a reduced risk of cancer plus many other chronic disease conditions. One of the staples of this diet is tomatoes, especially the low-acid varieties that are grown in Italy and its impact on cancer risk is quite interesting. Recent research by the Sbarro Institute for Molecular Medicine at Temple University in Philadelphia, Pa. has confirmed that two tomato cultivars grown in Southern Italy inhibit both malignant features and cellular growth in stomach cancer cells. For the study, whole tomato lipophilic extracts were analyzed for their ability to fight and diminish neoplastic features of stomach cancer cells. Both the Corbarino and San Marzano tomato varieties were found to inhibit the cloning behavior of malignant cancer cells as well as impede their growth. When tomato extracts were used on stomach cancer cells, key processes related to cell development, migration and proliferation were inhibited. The tomato extracts ultimately induced apoptosis, or cancer cell death in cancer cells. The study results were published in the Journal of Cellular Physiology. Significantly, the tomato extracts contributed to the movement of cancer cells away from the primary tumor, which resulted in their death. These anticancer effects weren't related to just one particular compound such as lycopene. Instead, the whole tomato seemed to contribute to its anticancer effects. Previous studies had suggested the carotenoid compound lycopene, which creates the orange-red color of tomatoes, is what fights cancer cells. While lycopene may still be a major factor, the entire tomato seemed to have a highly potent effect against cancer. Amino Acid Arginine Found As Effective As Drugs For Glucose Metabolism And DiabetesUniversity of Copenhagen & University of Cincinnati, October 9, 2022 If you suffer from type 2 diabetes, you may want to consider snacking on nuts to treat the condition. Supplementation with the amino acid arginine, commonly found in almonds and hazelnuts, could help to improve glucose metabolism by as much as 40%, according to new research in mice. The study shows that supplementation with the amino acid significantly improves glucose metabolism in both insulin-sensitive and insulin-resistant metabolisms. In new experiments, researchers from the University of Copenhagen working in collaboration with a research group at the University of Cincinnati, have demonstrated that the amino acid arginine, found in salmon, eggs, and nuts, improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice.

”In fact, the amino acid is just as effective as several well-established drugs for type 2 diabetics,” says postdoc Christoffer Clemmensen.  As improbable as it may seem, the most important molecule in regulating the function of our arteries is nitric oxide (NO), a gas better known to us as an air pollutant. As synthesized in our arteries in tiny quantities, however, NO acts as a powerful mediator of vasodilation, the mechanism by which arteries dilate, when necessary, to lower our blood pressure and increase the flow of blood to tissues that need it. The principal source of our NO is arginine. This occurs via enzyme-catalyzed reactions that occur in endothelial cells, the thin layer of smooth, tightly “tiled” cells that line the inner walls of our arteries. 

What researchers have found is that L-arginine potentiation of glucose-induced insulin secretion occurs independently of NO.

 The researchers found that arginine improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. “We can also see that arginine increases the body's production of glucagon-like peptide-1 (GLP-1), an intestinal hormone which plays an important role in regulating appetite and glucose metabolism, and which is therefore used in numerous drugs for treating type 2 diabetes,” said Clemmensen. Supplemental dosages of 6 to 8 grams L-Arginine per day are considered safe. Although available in food, for some applications such as stimulating secretion of growth hormone from the pituitary, it is not released quickly enough as the food is digested. The supplemental doses taken on an empty stomach will arrive at the blood-brain barrier without competition. Then growth hormone secretion will be stimulated which in turn can affect glucose metabolism Increasing green space could narrow lifespan gap between poorest and richest areas University of Glasgow (Scotland), October 19, 2022 Increasing the amount of natural (green and blue) space and private gardens has the potential to narrow the lifespan gap between those living in the most and least deprived areas, suggests research published online in the Journal of Epidemiology of Community Health. Each 10% increase in natural space is linked to a 7% fall in the incidence of early death among the under 65s, the findings indicate.  It's not clear if access to natural space might also be associated with differences in lifespan and protection against an earlier than expected death, so the researchers used the measure of “years of life lost,” or YLL for short, to try and find out. Natural space was defined as: woodland; scattered trees; scrub; marsh; heath; open water (inland or tidal); semi natural grassland; general natural areas, such as grass on sports pitches, roadside verges, and farmland; agriculture; hard bare ground, such as rocks, boulders, and cliffs; and soft bare ground, such as sand, soil, and foreshore. Areas with the highest income deprivation had the lowest average percentage cover of natural space and gardens (58.5%, 49–65%). People living in these areas had the highest levels of ill health. The study found that every 10% increase in natural space cover was associated with a 7% fall in the incidence of premature death.  Food for thought: Study finds link between depression and unhealthy diets Macquarie University, October 18, 2022 A Macquarie University study of 169 adults aged 17 to 35 found those eating a Western-style diet were more likely to have lower levels of kynurenic acid (KA)—a small molecule important to a number of bodily functions—and report higher levels of depression than those eating diets rich in fresh fruit and vegetables. Neuroscientist Dr. Edwin Lim and neuropsychologist Dr. Heather Francis published a paper on the findings of the study in the journal Frontiers in Nutrition. “Western-style diets high in fat, sugar and processed foods were already known to increase the risk of depression, but this is the first time a biological link involving the kynurenine pathway has been established,” Lim says. “People from the group eating an unhealthy diet had lower levels of KA and more severe symptoms of depression. This indicates that KA may help to protect us against depression.” The human body has a number of ways of producing important molecules and metabolites necessary to keep it functioning. One of these important molecules is tryptophan—an essential amino acid that the body can't make itself, that is found in foods like dairy products, poultry, bananas, oats, nuts and seeds. When tryptophan is broken down, it can produce either serotonin and melatonin—important for our mood and sleep—or it can be processed by the kynurenine pathway, which creates KA and other important metabolites linked to neurodegenerative diseases such as Alzheimer's disease. Lim says this is the first time anyone has been able to show that Western-style diet has an effect on the way that tryptophan is metabolized in otherwise healthy young people. “There is, however, a clear relationship between an increased risk of depression and eating an unhealthy diet that is high in fat, sugar and processed foods, giving us all the incentive to eat more fresh vegetables and fruit,” she says. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2022 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Patients who ate fish, vegetables and whole grains reported a greater reduction in symptoms than those on proton pump inhibitors (PPIs), the study found Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe.  In the study, published in the journal JAMA Otolaryngology – experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.'   Shorter sleep in later life linked to higher risk of multiple diseases University College London, October 19, 2022 Getting less than five hours of sleep in mid-to-late life could be linked to an increased risk of developing at least two chronic diseases, finds a new study led by UCL researchers. The research, published in PLOS Medicine, analyzed the impact of sleep duration on the health of more than 7,000 men and women at the ages of 50, 60 and 70, from the Whitehall II cohort study. Researchers examined the relationship between how long each participant slept for, mortality and whether they had been diagnosed with two or more chronic diseases(multimorbidity)—such as heart disease, cancer or diabetes—over the course of 25 years. People who reported getting five hours of sleep or less at age 50 were 20% more likely to have been diagnosed with a chronic disease and 40% more likely to be diagnosed with two or more chronic diseases over 25 years, compared to people who slept for up to seven hours. Additionally, sleeping for five hours or less at the age of 50, 60, and 70 was linked to a 30% to 40% increased risk of multimorbidity when compared with those who slept for up to seven hours. Researchers also found that sleep duration of five hours or less at age 50 was associated with 25% increased risk of mortality over the 25 years of follow-up—which can mainly be explained by the fact that short sleep duration increases the risk of chronic disease(s) that in turn increase the risk of death. “Our findings show that short sleep duration is also associated with multimorbidity. As part of the study, researchers also assessed whether sleeping for a long duration, of nine hours or more, affected health outcomes. There was no clear association between long sleep durations at age 50 and multimorbidity in healthy people. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2017 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe.  In the study, published in the journal JAMA Otolaryngology, experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.'

Vol 217, Issue 6: 19 September 2022. Professor Ginny Barbour will take over as Editor-in-Chief of the Medical Journal of Australia and InSight+ on 23 January 2023. She was one of the founding editors of PLOS Medicine, and is currently Director of Open Access Australasia. She talks with MJA news and online editor Cate Swannell about her vision for the MJA going forward. 

Dementia, which globally effected over 50 million people in 2019, is characterized by a progressive and unrelenting deterioration of mental capacity – compromising everyday activities.  Dementia is a symptom of underlying brain degeneration caused by vascular disease or traumatic brain injury, such as from accidents or contact sports like American football, brain tumors, and the list goes on.Dementia is classified into two distinct areas: Alzheimer disease and vascular dementia. Since a stroke doubles the risk of developing dementia, it's estimated that more than a third of the dementia cases could be prevented by reducing the risk to a stroke.According to research – Consumption of Coffee and Tea and the Risk of developing Stroke, Dementia, and Post-Stroke Dementia: A Cohort Study, which appeared in December 2021, in the open access, peer-reviewed journal Plos Medicine, “epidemiological and clinical studies have shown the benefits of coffee and tea separately in preventing dementia. However, little is known about the association between the combination of coffee and tea and the risk of dementia.” Chinese researchers sought to investigate the associations of coffee and tea separately and in combination with the risk of developing stroke, dementia, and poststroke dementia, based on data from a large population-based cohort – the UK, a population-based cohort study that recruited more than 500,000 participants (39 to 74 years old), who attended 1 of the 22 assessment centers across the UK between 2006 and 2010.365, 682 participants reported their coffee and tea consumption. The researchers determined that, “coffee intake of 2 to 3 cups/day or tea intake of 3 to 5 cups/day, or their combination intake of 4 to 6 cups/day were linked with the lowest hazard ratio (HR) of incident stroke and dementia.”It was also determined that consuming 2 to 3 cups of coffee with 2 to 3 cups of tea daily were associated with a 32% lower risk of stroke and a 28% lower risk of dementia – with the intake of coffee alone or in combination with tea being associated with lower risk of poststroke dementia. The Chinese investigators concluded that, “our findings support an association between moderate coffee and tea consumption and risk of stroke and dementia. However, whether the provision of such information can improve stroke and dementia outcomes remains to be determined.”

The system for publishing scientific research is broken.  Academic success is measured by citations rather than scientific quality. And publishing companies have a monopoly on the knowledge scientists produce. Can we use blockchain technology to promote the verifiability of scientific findings? And make science accessible to everyone? Dr. Christopher Hill is an interdisciplinary scientist with a background in neuroeconomics and machine learning. Phillip Koellinger is Professor of Social Science Genetics in the Department of Economics at Vrije Universiteit Amsterdam.  Together, Chris and Philipp are Cofounders of DeSci Labs, an initiative that aims to make science more replicable, accessible, transparent and fair by way of Web3 technologies. On this episode of Boost VC, Chris and Philipp join us to explain what inspired their interest in decentralized science and explore what differentiates success for science versus individual scientists. They walk us through the goals of the open science movement and weigh in on how DeSci tech provides new ways of funding research and makes scientific knowledge available to everyone. Listen in for insight around the grassroots movement known as metascience and learn how DeSci is working to improve the quality of the scientific record and reward scientists for the value they create. Topics Covered What inspired Chris & Philipp's interest in decentralized scienceBureaucracy and broken publishing system in academiaPassionate about open science, reproducibilityImprove durability and quality of scientific recordUplift material conditions of early-career scientists The goals of the open science movementMake research more transparent, accessible to everyoneBetter markers of scientific quality than impact factorImprove and promote verifiability and reproducibility  What differentiates success for science vs. success for scientistsScientific success = verifiable new knowledgeSuccess for scientist = prestige How Chris & Philipp define decentralized scienceTech stack for true open access to researchMakes science more transparent and reproducibleAllows scientists to recapture value they create The problem with measuring value by impact factor (IF)Metric derived exclusively from citation ratesPublishers have monopoly on scientific knowledge How DeSci technologies can benefit scientific researchAccelerate pace of knowledge progress and accessibilityProvide new ways of funding researchBusiness models that reward scientists for contributionsPotential for rapid experimentation at scaleCreate accountability in peer review process The interdisciplinary grassroots movement of metascienceCheck work of other scientists through replicationsConduct basic hygiene of scientific ecosystem The transition from scientific manuscripts to research objectsStore artifacts of journey, including peer review feedbackPermanent knowledge graphs to secure scientific record  Connect with Chris Hill & Philipp Koellinger DeSci Labs https://www.desci.com/DeSci Labs on Twitter https://twitter.com/descilabsDeSci Foundation https://descifoundation.org/DeSci Foundation on Twitter https://twitter.com/DeSciFoundation Resources David Deutsch https://www.daviddeutsch.org.uk/‘Raise Standards for Pre-Clinical Cancer Research' in Nature https://www.nature.com/articles/483531a‘Why Most Published Research Findings Are False' in PLOS Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182327/Gitcoin https://gitcoin.co/ Connect with Boost VC Boost VC Website https://www.boost.vc/Boost VC on Facebook https://www.facebook.com/boostvc/Boost VC on Twitter https://twitter.com/BoostVCBoost VC on Instagram https://www.instagram.com/boost_vc/

ADHD is a rising diagnosis in our society. Tune in to learn more about the possible causes hidden at the root of ADHD, including heavy metals.Every day we are exposed to toxins from our environment. We may ingest lead and copper from drinking water, phosphate from processed food and soda, various synthetic chemicals from plastic food containers, and pesticides from fruits and vegetables. Both natural heavy metals and man-made chemicals disrupt hormones and brain development. The brain, especially the developing brain, is very vulnerable to contaminants because of its large size and its high concentration of fats which serve as a reservoir for toxicants to build up. This episode will explain the role that heavy metals and environmental toxins play in ADHD.In January 2016, there was a declared state of emergency in Flint, Michigan where thousands of residents were exposed to high levels of lead in their drinking water. The corrosive water from the Flint River caused lead from old water pipes to leach into the water supply, putting up to 12,000 children at risk of consuming dangerous levels of lead. Lead poisoning can cause irreversible brain damage and even death, and growing children are especially susceptible to its poisonous effects. Even low blood lead levels reduce IQ, the ability to pay attention, motor function, and academic achievement.Since lead poisoning causes cognitive, motor, and behavioral changes, it is not surprising that it also causes ADHD. Lead exposure is estimated to account for 290,000 excess cases of ADHD in US children (Braun et al., 2006). A study on 270 mother-child pairs in Belgium found that doubling prenatal lead exposure (measured in cord blood) was associated with a more than three times higher risk for hyperactivity in boys and girls at age 7-8 (Sioen et al., 2013). A larger study on almost 5,000 US children aged 4-15 found children with the highest blood lead levels were over four times as likely to have ADHD as children with the lowest blood lead levels (Braun et al., 2006).MRI scans from participants of the Cincinnati Lead Study had striking results: childhood lead exposure was associated with brain volume loss in adulthood. Individuals with higher blood lead levels as children had less gray matter in some brain areas. The main brain region affected was the prefrontal cortex which is responsible for executive function, behavioral regulation, and fine motor control (Cecil et al., 2008).Copper is an essential trace mineral we must consume from our food supply. It is found in oysters and other shellfish, whole grains, beans, nuts, and potatoes. Like lead, copper can leach into the water supply when copper pipes corrode. One of copper's roles in the body is to help produce dopamine, the neurotransmitter that provides alertness. However, too much copper creates an excess of dopamine leading to an excess of the neurotransmitter norepinephrine. High levels of these neurotransmitters lead to symptoms similar to ADHD symptoms: hyperactivity, impulsivity, agitation, irritability, and aggressiveness. In children with excess copper, stimulant medications don't work as well and tend to cause side effects (agitation, anxiousness, change in sleep and appetite). Most ADHD medications work by increasing levels of dopamine, intensifying the effects of excess copper. In addition, excess copper blocks the production of serotonin, a mood-balancing neurotransmitter. This triggers emotional, mental, and behavioral problems, from depression and anxiety to paranoia and psychosis.The neurotoxic effects of excess copper are well known and a few studies have assessed copper's role in ADHD symptoms. When researchers compared copper levels in 58 ADHD children to levels in 50 control children, they observed that copper levels were higher in ADHD children. ADHD children also had a higher copper-to-zinc ratio that positively correlated with teacher-rated inattention  Now let's move into Phosphate. Phosphate is a charged particle (an electrolyte) that contains phosphorus. Phosphorus is the second most abundant mineral in the body (the first is calcium). Phosphorus is a building block for bones and about 85% of total body phosphorus is found in the bones. Deficiencies are rare because phosphorus is naturally abundant in protein-rich foods like meat, poultry, fish, eggs, milk, and milk products as well as in nuts, legumes, cereals, and grains. Although phosphorus is an essential nutrient, too much can be problematic. The phosphate content of processed foods is much higher than that of natural foods because phosphates are commonly used as additives and preservatives in food production. Our daily intake of phosphate food additives has more than doubled since the 1990's (Ritz et al., 2012). Phosphorus, especially the form found in processed meats, canned fish, baked goods, and soda is quickly absorbed into the bloodstream so levels can rise rapidly.Phosphorus reduces the absorption of other vital nutrients, many of which ADHD children are deficient in to begin with. For instance, too much phosphorus can lower calcium levels. High phosphorus coupled with low calcium intake leads to poor bone health. The typical American diet contains two to four times more phosphorus than calcium and soda is often a major contributor to this imbalance. In the body, phosphorus and magnesium bind together, making both minerals unavailable for absorption. This is most apparent when magnesium consumption is low and intake of phosphorus is high. Researchers have found that adding Pepsi to men's diet for two consecutive days causes their blood phosphate levels to increase and their magnesium excretion to decrease (Weiss et al., 1992).In the 1990's, German pharmacist Hertha Hafer discovered that excess dietary phosphate triggered her son's ADHD symptoms. In her book, The Hidden Drug, Dietary Phosphate: Cause of Behavior Problems, Learning Difficulties and Juvenile Delinquency, she presents a low phosphate diet as a treatment for ADHD. A low phosphate diet led to dramatic improvements in her son's behavior, well-being, and school performance, rendering medication unnecessary. Her family's ADHD problem was resolved and her son had no further problems as long as he avoided high phosphate foods. Hafer finds that children with mild ADHD can improve simply by removing processed meats and phosphate-containing beverages like soda and sports drinks from their diets (Waterhouse, 2008).Everyday plastic products contain hormone-disrupting chemicals, such as Bisphenol A (BPA) and phthalates, that can migrate into our body and affect the brain and nervous system. These environmental toxins bind to zinc and deplete zinc levels in the body. Phthalates are synthetic chemicals used to make plastics soft and flexible. Phthalates are used in hundreds of consumer products and humans are exposed to them daily through air, water, and food. Multiple studies have linked phthalates with ADHD. Researchers assessed the urine phthalate concentrations and ADHD symptoms ADHD symptoms (inattention and hyperactivity/impulsivity), rated by the children's teachers, were significantly associated with phthalate metabolites (breakdown products) (Kim et al., 2009).Prenatal phthalate exposure is associated with problems in childhood behavior and executive functioning. Third-trimester urines from 188 pregnant women were collected and analyzed for phthalate metabolites. Their children were assessed for cognitive and behavioral development between the ages of 4 and 9. Phthalate metabolites were associated with worse aggression, conduct problems, attention problems, depression, externalizing problems, and emotional control (Engel et al., 2010).In addition to heavy metals and plasticizers, pesticides can cause ADHD symptoms. The American Academy of Pediatrics notes, “Children encounter pesticides daily in air, food, dust, and soil. For many children, diet may be the most influential source. Studies link early-life exposure to organophosphate insecticides with reductions in IQ and abnormal behaviors associated with ADHD and autism” (Roberts & Karr, 2012).Among pesticides, insecticides may be the most harmful to humans. Insecticides were first developed during World War II as nerve gases. They work by targeting and destroying, an enzyme that controls the neurotransmitter acetylcholine which plays a role in attention, learning, and short-term memory. Even organophosphate exposure at low levels common among US children may contribute to ADHD prevalence. Researchers at Harvard University studied more than 1,000 children aged 8-15 from the general population and found that those with detectable urinary levels of an OP metabolite were nearly twice as likely to be diagnosed with ADHD (Bouchard et al., 2010).Source: JAMES GREENBLATT, MD REFERENCES:Braun et al (2006). Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspectives, 114(12), 1904-1909.Cecil et al. (2008). Decreased Brain Volume in Adults with Childhood Lead Exposure. PLoS Medicine, 5(5), PLoS Medicine, 2008, Vol.5(5).Engel et al. (2010). Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environmental Health Perspectives, 118(4), 565-71.Evans et al. (2014). Prenatal bisphenol A exposure and maternally reported behavior in boys and girls. Neurotoxicology, 45, 91-99.Kicinski et al. (2015). Neurobehavioral function and low-level metal exposure in adolescents. International Journal of Hygiene and Environmental Health, 218(1), 139-146.

Artificial sweeteners like aspartame might be associated with an increased risk of certain types of cancer. In a new study published in the journal PLOS Medicine, French researchers analyzed data from over 100,000 adults. They found that the participants who consumed the most artificial sweeteners in their diets, especially aspartame and acesulfame-K, had higher risks […] The post 161. Artificial sweeteners linked to increased risk of certain cancers appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Monologue Dr. Joel Wallach begins the show discussing his various books he has written. Stating the information in those books can help people add 20 to 50 years to their life. Citing the story of how he discovered what killed 500 lambs in one night. The lambs had been slowly been poisoned with nitrates from a neighbor's field running into the water the lambs were drinking. Pearls of Wisdom Doug Winfrey and Dr. Wallach discuss a news article regarding a study published in the journal PLOS Medicine. The study found a link between consuming artificial sweeteners and cancer. In the study participants who consumed the highest levels of artificial sweeteners had a greater overall risk of cancer, with the highest risks observed for breast cancer and obesity-related cancer. Callers Maxine has vitaligo, hair loss and psoriasis. Randall is experiencing vertigo and dizziness his doctor telling him the lower portion of his heart isn't pumping enough blood. Sandra has been diagnosed with Huntington's disease. Call Dr. Wallach's live radio program weekday from noon until 1pm pacific time at 831-685-1080 or toll free at 888-379-2552.

Spending time in research can deliver the humbling, but needed, reminder that not all therapy leads to clear value for our clients. For example, in the United States, we can now see that in the 2010s therapy was being delivered in skilled nursing facilities (SNFs)—beyond what was helpful for clients. Part of the problem was the fee-for-service payment model that incentivized skilled nursing facilities to deliver high quantities of therapy minutes to as many patients as possible. (More therapy equaled more money.) The research article that we will explore in this one hour course, shows us the humbling data behind this problem. And, it reminds us of why the transition to value-based care continues to happen. The authors specifically look at data around post-acute hip fracture rehab, and compare fee-for-service Medicare versus Medicare Advantage (which is a value-based care program.)To help us make sense of the changing therapy landscape, we are thrilled to welcome Clarice Grote, MS, OTR/L, is an innovative advocate for occupational therapy and an expert on Medicare post-acute care policy. Clarice will help us understand how this research applies to your individual practice. In order to earn credit for this course, you must take the test within the OT Potential Club.You can find more details on this course here:https://otpotential.com/ceu-podcast-courses/payment-models-in-post-acute-otHere's the primary research we are discussing:Kumar, A., Rahman, M., Trivedi, A. N., Resnik, L., Gozalo, P., &; Mor, V. (2018). Comparing post-acute rehabilitation use, length of stay, and outcomes experienced by Medicare fee-for-service and Medicare advantage beneficiaries with hip fracture in the United States: A secondary analysis of administrative data. PLOS Medicine, 15(6).Support the show (https://otpotential.com)

In this episode, I review an article on alternatives to Ibuprofen. This episode is sponsored by McNeese Construction. You can also read this episode on our blog at https://yopistudio.blogspot.com/2022/03/natural-alternatives-for-ibuprofen.html To keep this podcast going please feel free to donate at www.paypal.me/yopistudio If you would like to read more on this topic or any other previous topics, you can do so by checking out our blog at https://yopistudio.blogspot.com/ Feel free to see what we are up to by following us at:  https://twitter.com/Dauricee https://parler.com/profile/Daurice/ https://www.facebook.com/yopistudio/ https://www.facebook.com/LouisianaEntertainmentAssociation/ To listen to the podcast, watch creative videos and skits go to https://www.youtube.com/channel/UCvn6tns6wKUwz9xZw11_vAQ/videos Interested in projects Daurice has worked on in the movie industry you can check it out at www.IMDb.com under Daurice Cummings. Please add us to your RSS Feed, & iTunes, iHeart, Spotify, Stitcher, Google Pod, Sound Cloud, and our favorite Podbean! For comments or questions, you can reach us at yopi@post.com To read more about today's topic check out the references below. References: https://www.forbes.com/2004/12/13/cx_mh_1213faceoftheyear.html?sh=7432b7776d57 https://www.reuters.com/article/us-painkillers-risks/high-doses-of-common-painkillers-increase-heart-attack-risks-idUSBRE94S1FV20130529?feedType=RSS&feedName=healthNews https://www.greenmedinfo.com/blog/ibuprofen-kills-more-pain-so-what-alternatives https://www.greenmedinfo.com/blog/ibuprofen-can-stop-your-heart-31-increase-cardiac-arrest-risk https://www.greenmedinfo.com/blog/ibuprofen-deadly-vioxx https://www.greenmedinfo.com/toxic-ingredient/ibuprofen https://www.greenmedinfo.com/substance/arnica https://www.greenmedinfo.com/article/topical-treatment-arnica-effective-ibuprofen-hand-osteoarthritis https://www.greenmedinfo.com/substance/ginger https://www.greenmedinfo.com/article/ginger-effective-mefenamic-acid-and-ibuprofen-relieving-pain-women-primary-dys https://www.greenmedinfo.com/substance/turmeric https://www.greenmedinfo.com/article/efficacy-and-safety-curcuma-domestica-extracts-compared-ibuprofen-patients-kne https://www.greenmedinfo.com/substance/thyme https://www.greenmedinfo.com/article/thymus-vulgaris-least-effective-ibuprofen-reducing-severity-pain-and-spasm-pri https://www.greenmedinfo.com/substance/omega-3-fatty-acids https://www.greenmedinfo.com/article/omega-3-fatty-acids-are-effective-alternative-ibuprofen-reducing-arthritic-pai https://www.greenmedinfo.com/substance/cinnamon https://www.greenmedinfo.com/blog/cinnamon-beats-ibuprofen-pain-study-reveals-2 https://www.greenmedinfo.com/pharmacological-action/anti-inflammatory-agents https://www.greenmedinfo.com/pharmacological-action/analgesics https://www.greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-1 https://www.greenmedinfo.com/toxic-ingredient/non-steroidal-anti-inflammatory-drugs-nsaids Fitzgerald, G.A. (2001). The coxibs, selective inhibitors of cyclooxygenase-2. New England Journal of Medicine, 345, 433-442. Fitzgerald, G.A. (2004). Coxibs and cardiovascular disease. The New England Journal of Medicine, 351(17), 1709-1711.  Coxib and traditional NSAID Trialists' (CNT) Collaboration et al. (2013). Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet, 382(9849), 769-779. doi: 10.1016/S0140-6736(13)60900-9 Mukherjee, D., Nissen, S.E., & Topol, E.J. (2001). Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors. Journal of the American Medical Association, 286(8), 954-959. doi:10.1001/jama.286.8.954doi:10.1001/jama.286.8.954 Singh, D. (2004). Merck withdraws arthritis drug worldwide. The British Medical Journal, 329. doi: link.  Berenson et al. (2004). Despite Warnings, Drug Giant Took Long Path to Vioxx Recall. The New York Times. Retrieved from here.  Tanne, J.H. (2008). Merck used ghostwriters and selective data in Vioxx publications, JAMA says. British Medical Journal, 336(849). doi: link.  Steenhuysen, J. (2009). Vioxx risks could have been detected earlier: study. Reuters. Retrieved from here. Willson, D. (2011). Merck to Pay $950 Million Over Vioxx. The New York Times. Retrieved from here. The Associated Press. (2010). Supreme Court Allows Investors to Sue Merck Over Vioxx. The New York Times. Retrieved from here.  ConsumerAffairs. (2004). The Food and Drug Administration (FDA) estimates that Vioxx may have contributed to 27,785 heart attacks. Retrieved from here.  Kearney et al. (2006). Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drug increase the risk of atherothrombosis? Meta-analysis of randomised trials. British Medical Journal, 332, 1302-1308.  McGettigan, P., & Henry, D. (2011). Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Medicine, 8, e1001098.  Trelle et al. (2011). Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. British Medical Journal, 342, c7086.  Sostres, C., Gargallo, C.J., & Lanas, A. (2013). Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Research Therapies, 15(Suppl 3), S3.   Marlicz et al. (2014). Nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and gastrointestinal injury: contrasting interactions in the stomach and small intestine. Mayo Clinic Proceedings, 89(12), 1699-1709.  Maiden et al. (2005). A quantitative analysis of NSAID-induced small bowel pathology by capsule endoscopy. Gastroenterology, 128(5), 1172-1178. Goldstein et al. (2005). Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole and placebo. Clinical Gastroenterology and Hepatology, 3(2), 133-141.  Shiotani et al. (2010). Randomized, double-blind pilot study of gnarly geranylacetone versus placebo in patients taking low dose enteric-coated aspirin: low-dose aspirin-induced small bowel damage. Scandinavian Journal of Gastroenterology, 45(3), 292-298.  Caunedo-Alvarez et al. (2010). Macroscopic small bowel mucosal injury caused by chronic non steroidal anti-inflammatory drugs (NSAIDs) use as assessed by capsule endoscopy. Rev Esp Enferm Dig, 102(2), 80-85. Kent, T.H., Cardelli, R.M., & Stamler, F.W. (1969). Small intestinal ulcers and intestinal flora in rats given indomethacin. American Journal of Pathology, 54(2), 237-249. Uejima et al. (1996). Role of intestinal bacteria in ileal ulcer formation in rats treated with a non steroidal anti-inflammatory drug. Microbiology and Immunology, 40(8), 553-560.  Watanbe et al. (2008). Non-steroidal anti-inflammatory drug-induced intestinal damage is Toll like 4 receptor dependent. Gut, 57(2), 181-187. Fasano, A. (2012). Leaky gut and autoimmune disease. Clinical Reviews in Allergy and Immunology, 42(1), 71-78.  Lanza, F.L., Chan, F.K., & Quigley, E.M. (2009). Practice parameters committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(2), 728-238.  Bhatt et al. (2008). ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of anti platelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation, 118(18), 1894-1909.  American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis and Rheumatology, 46(2), 328-346.  Wallace et al. (2011). Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 141(4), 1314-1322.   Endo et al. (2011). Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study. Journal of Gastroenterology, 46(7), 894-905.  Bhala et al. (2013). Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. The Lancet, 382(9894), 769-779.  Montenegro et al. (2014). Non steroidal anti-inflammatory drug induced damage on lower gastro-intestinal tract: is there an involvement of microbiota? Current Drug Safety, 9(3), 196-204. Ozgoli, G., Goli, M., & Moattar, F. (2009). Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. Journal of Alternative and Complementary Medicine, 15(2), 129-132. doi: 10.1089/acm.2008.0311. Salmalian et al. (2014). Comparative effect of thymus vulgaris and ibuprofen on primary dysmenorrhea: A triple-blind clinical study. Caspian Journal of Internal Medicine, 5(2), 82-88.  Levy et al. (2009). Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Nutrition Research, 29(5), 298-304. doi: 10.1016/j.nutres.2009.04.003. Conrozier et al. (2014). A Complex of Three Natural Anti-inflammatory Agents Provides Relief of Osteoarthritis Pain. Alternative Therapies in Health and Medicine, 20(Suppl 1), 32-37.  Chiu et al. (2016). Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician, 19(1), E97-E112. Diener et al. (2005). Efficacy and safety of 6.25 mg tid feverfew CO2‐extract (MIG‐99) in migraine prevention—a randomized, double‐blind, multicentre, Placebo‐controlled study. Cephalalgia, 25(11), 1031–1041. Lipton et al. (2004). Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology, 63(12), 2240-2244.  Shara, M., & Stohs, S.J. (2015). Efficacy and Safety of White Willow Bark (Salix alba) Extracts. Physiotherapy Research, 29(8), 1112-1116. doi: 10.1002/ptr.5377. Vlachojannis, J.E., Cameron, M., & Chrubasik, S. (2009). A systematic review on the effectiveness of willow bark for musculoskeletal pain. Phytotherapy Research, 23(7), 897-900. doi: 10.1002/ptr.2747. Wesolowska et al. (2006). Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. Journal of Ethnopharmacology, 107, 254-258. Gupta, S.K., & Ansari, S.H. (2005). Review on phytochemical and pharmacological aspects of Cichorium intybus L. Asian Journal of Chemistry, 17, 33-36. Tall et al. (2004). Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Brain and Behavior Research, 153(1), 181-188. Seeram et al. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine, 8(5), 362-369. Kuehl et al. (2010). Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. Journal of International Society of Sports Nutrition, 7, 17. doi: 10.1186/1550-2783-7-17. Illich, I. (1974). Medical Nemesis: The Expropriation of Health. New York: Pantheon Books. Capone et al. (2004). Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.          

It this episode, Dr. Jeff Armstrong and Corbin Bruton discuss the following paper:Fadnes, L. T.,  Økland, J.-M., Haaland , Ø. A., & Johansson, K. A. (2022). Estimating impact of food choices on life expectancy: A modeling study. PLoS Medicine, 19(2): e1003889 https://doi.org/10.1371/journal.pmed.1003889Have questions you want answered and topics your want discussed on "Aging Well"? Send us an email at agingwell.podcast@gmail.com.

Getting healthier is hard. Here are three tips for making adopting healthy habits easier from certified personal trainer and health coach, Tatiana Boncompagni.Know that the beginning is the hardest and prepare for it. Use meal plans (from books or apps), trainers, and meal delivery services) to provide the structure and accountability you may need to get through the early days. Avoid decision fatigue. The more you take away the chance to stray from your diet, the more likely you are to stick to the plan.Don't be afraid to say "no" to situations that might make sticking to your eating plan hard. When you say "no," you are really saying YES to yourself and reinforcing that you matter. (You do!!) Most importantly stay inspired. Surround yourself with others who have accomplished what you want to; their success tells you it is possible and that "if they can do it, so can you!"Did you know that switching to a Mediterranean Diet -- ranked #1 diet by US News and World Report for 5 years running -- can boost your lifespan up to 13 years, according to a recent report published by PLoS Medicine, a peer-reviewed medical journal.The study showed that men could increase their longevity by 13 years and women by 10 years if they switched to a diet that is high in vegetables, legumes and fish and poultry and low in processed and high-sugar foods. The best part? Researchers found that diet improvements even in mid-life or later have a positive impact on longevity.In other words, it's never too late to switch up your habits.Don't forget, you can order Eat Sunny to support you so you can crush all your goals in and out of the kitchen in 2022!

Improving your diet could add over a decade to your life, and even more if you start early. In a new study published in the journal PLOS Medicine, researchers from Norway used data from the Global Burden of Disease study, which tracks causes of death, diseases and injuries, and risk factors from patients around the […] The post 130. Improving your diet could add over a decade to your life appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Um estudo feito por pesquisadores da Universidade de Bergen, na Noruega, e publicado na revista científica PLOS Medicine, mostrou que aumentar o consumo de leguminosas, como feijão, ervilha e lentilha, e reduzir o consumo de carne vermelha pode adicionar até 13 anos à sua vida. O trabalho mostra que quanto mais cedo a mudança de alimentação começar, maior é a expectativa de vida da pessoa. Assunto para Roberta Larica, nesta edição do Boa Mesa CBN, que indica quais alimentos incluir nesta dieta. Ouça:

One of the leading causes of the growing rates of childhood obesity has been sugary drinks, like sodas and juices. In a new study published in the journal PLOS Medicine, researchers at the University of North Carolina tested pictured warning labels on the drinks to see if they discouraged parents from buying them for their […] The post 119. Picture warnings on sugary drinks might decrease childhood obesity appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Eating prunes may help protect against bone loss in older women Penn State University, February 9, 2022 It's already well known that prunes are good for your gut, but new Penn State research suggests they may be good for bone health, too. In a research review, the researchers found that prunes can help prevent or delay bone loss in postmenopausal women, possibly due to their ability to reduce inflammation and oxidative stress, both of which contribute to bone loss. “In postmenopausal women, lower levels of estrogen can trigger a rise of oxidative stress and inflammation, increasing the risk of weakening bones that may lead to fractures,” said Connie Rogers, associate professor of nutritional sciences and physiology. “Incorporating prunes into the diet may help protect bones by slowing or reversing this process.” (NEXT) Can correcting micronutrient deficiencies help treat heart failure?  University Medical Center Groningen (Netherlands), February 9, 2022 A review published in the Journal of Internal Medicine provides convincing evidence that micronutrients—including iron, selenium, zinc, copper, and coenzyme Q10—can impact the function of cardiac cells' energy-producing mitochondria to contribute to heart failure. The findings suggest that micronutrient supplementation could represent an effective treatment for heart failure. “Micronutrient deficiency has a high impact on mitochondrial energy production and should be considered an additional factor in the heart failure equation, moving our view of the failing heart away from “an engine out of fuel” to “a defective engine on a path to self-destruction,” said co–lead author Nils Bomer, PhD, of the University Medical Center Groningen. (NEXT) Could meditation reduce brain aging? University of California-Los Angeles   February 7, 2022  It is common knowledge that the brain deteriorates as we age, causing functional impairments. You may be surprised to learn that this process usually begins during mid-to-late-20s. But before you panic, a new study suggests a potential way to reduce such deterioration: meditation. The research team at the Brain Mapping Center at the University of California-Los Angeles (UCLA), found meditation may be associated with better preservation of gray matter in the brain – the neuron-containing tissue responsible for processing information. The researchers recruited 100 subjects to the study aged 24-77. Of these, 50 had meditated for between 4 and 46 years and 50 had never engaged in the practice. Both groups were closely matched for age. (NEXT) The Power Of Tea Washington University, February 6, 2022 A compound found in green tea could have life saving potential for patients with multiple myeloma and amyloidosis, who face often-fatal medical complications associated with bone-marrow disorders, according to a team of engineers at Washington University in St. Louis and their German collaborators. Jan Bieschke, assistant professor of biomedical engineering  says the compound epigallocatechine-3-gallate (EGCG), a polyphenol found in green tea leaves, may be of particular benefit to patients struggling with multiple myeloma and amyloidosis. These patients are susceptible to a frequently fatal condition called light chain amyloidosis, in which parts of the body's own antibodies become misshapen and can accumulate in various organs, including the heart and kidneys. (NEXT) Changing your diet could add up to a decade to life expectancy, study finds University of Bergen (Norway), February 8, 2022 A young adult in the U.S. could add more than a decade to their life expectancy by changing their diet from a typical Western diet to an optimized diet that includes more legumes, whole grains and nuts, and less red and processed meat, according to a new study published  in PLOS Medicine. For older people, the anticipated gains to life expectancy from such dietary changes would be smaller but still substantial. In the new study, researchers used existing meta-analyses and data from the Global Burden of Diseases study to build a model that enables the instant estimation of the effect on life expectancy (LE) of a range of dietary changes. (VIDEOS) Every news media who secretly took Trudeau's $61M pre-election pay-off – (13 minutes) Mary Holland – Protect Our Children (3:44 minutes) Canadian truckers are ‘doing something wonderful for the world' says Brendan O'Neill (OTHER NEWS) How Fact Checking Is Controlled and Faked Epoch Times, February 09, 2022 Prior to 2015 or 2016, you could still read what you wanted online without much interference. This has since changed, as propagandists have infiltrated the media and, along with other major players, like Big Tech and government, set out to control information. Fact-checking — a once-obscure term that's since gone mainstream — is one part of the campaign to control what you see online, and therefore what you think and how you perceive reality — but it's all a ruse. Speaking with Jan Jekielek, The Epoch Times senior editor and host of the show “American Thought Leaders,” investigative journalist Sharyl Attkisson explains how virtually everything you see and hear online has been co-opted, or taken over to serve a greater agenda:1 “One has to understand that nearly every mode of information has been co-opted, if it can be co-opted by some group. Fact checks are no different either, they've been coopted in many instances or created for the purpose of distributing narratives and propaganda. And your common sense is accurate when it tells you that the way they chose this fact check and how they decided to word it so they could say this thing is not true when at its heart it really is true, but the message they're trying to send is that you shouldn't believe it, your common sense is right. That's been created as part of a propaganda effort by somebody, somewhere, as part of a narrative to distribute to the public so virtually every piece of information that can be co-opted has been.” The Information Landscape Is Being Controlled Attkisson calls out several common online sources that are heavily manipulated — Wikipedia, Snopes and most “fact” checkers to name a few, along with HealthFeedback.org, which is a fake science group used by Facebook and other Big Tech companies to debunk science that is actually true. Fact checkers are often referred to as scientists, but this, too, is “part of a very well-funded, well-organized landscape that dictates and slants the information they want us to have.” While there have always been efforts to shape the information being given out by the media, it used to be that news reporters would push back against organizations to ensure the public had the other side of the story. Beginning in the early 2000s, Attkisson noted a shift from efforts to simply shape information to those that attempt to keep certain information from being reported at all. This was particularly true among the pharmaceutical companies she was covering at that time. Attkisson described “efforts by these large global PR firms that have been hired by the pharmaceutical industry, by government partners that work with the pharmaceutical industry, to keep the story from being reported at all.”2 Now, instead of real journalists and reporters, the media is infiltrated with propagandists who dictate what's “fake news” and what's not. Many believe that fake news is a product of Trump, but Big Tech was brought into the campaign early on. A lobby campaign by behind-the-scenes propagandists met with Facebook and said you've got to start censoring and “fact” checking information, Attkisson said. Attkisson states that it goes much deeper. A lot of propagandists have become part of the media, and while there used to be a firewall between reporters and the people they reported on, “that's long gone.” She says:6 “We've not just invited them to influence what we report, but we've hired them, not just as pundits and analysts but they are reporters. They are editorial presences within our newsrooms. Now we are one and the same. It's hard to say that there's a distinctive difference in many instances between the people trying to get out a message and the messengers in the media who should be doing a more independent job of reporting accurately.” Reality Is Being Altered in Real Time As it stands, information is being changed in real time to meet the common agenda. This includes definitions in dictionaries and on official government websites. Examples of definitions that have been changed recently include those for pandemic, herd immunity, vaccines and anti-vaxxer. Attkisson reiterates:17 “Virtually every form of information and sourcing that can be co-opted has been. That includes the dictionary definitions; that includes everything because these are important ways to influence thought. Language is very powerful. People don't want to be affiliated with certain names and labels. It reminds me of ‘1984,' the George Orwell story about the futuristic society, under which history was being rewritten in real time to jive with the version that the government wanted or the party wanted it to be. Definitions now are being rewritten and changed in real time to fit with the vision that the establishment wants people to think.” The Truth Finds a Way To Be Told While there are powerful forces at play to control information, all is not lost. Attkisson is aware of three entities that are actively working on a solution, which include: Investors who want to invest in independent news organizations Technical people trying to invent platforms that can't be controlled and deplatformed by Big Tech Journalists who want to work or contribute to these efforts Outlets like Substack newsletters and the video platforms Rumble, Bitchute and Odysee, which don't censor videos for ideological reasons, are actively getting around the censorship of Big Tech, and Attkisson believes that these efforts will accelerate in the next couple of years. Further, she says, “The propagandists may have overplayed their hand by being so heavy-handed and obvious about the control of information and the censorship. It's no longer deniable. Even people who want their information curated, they can't always be happy with the notion that they're not going to be able to get the full story, or that they're only getting one side of something.”24 Ultimately, she adds, “I think the truth finds a way to be told … it may take some time and there may be a lot of people that don't want the truth out, but we inherently as humans seek it.”25 On a personal level, you can go a long way toward finding the truth by following your own common sense and reason, and Attkisson agrees. “I always say, do your own research, make up your own mind, think for yourself. Trust your cognitive dissonance, use your common sense. You're going to be right more often than you think, but open up your mind, read a lot, think a lot and don't buy into the prevailing narrative at face value.” (NEXT) Opioid Overdose Deaths Cost U.S. Economy $1 Trillion A Year, Study Finds Forbes, February 8, 2022 Opioid overdose deaths cost the U.S. economy $1 trillion a year, the U.S. Commission on Combating Synthetic Opioid Trafficking said Tuesday, a “staggering amount” it says underlines the “direct and escalating threat” the opioid epidemic poses to the economy, public health and safety and national security. The panel came up with the estimate based on a White House Council of Economic Advisors' 2018 report that determined the cost of overdose fatalities amounted to $696 billion a year at a time when the death toll was about two thirds of today's. Between June 2020 and May 2021, 100,000 Americans died from drug overdoses, 30% higher than the year before and more than double the number of deaths caused by car accidents or gun violence during that period. About two thirds of those deaths involved synthetic opioids like fentanyl and primarily affected victims between the ages of 15 and 45, the report says. The loss of productivity and increases in healthcare and criminal justice costs tied to opioid overdose deaths amounted to a cost of about $700 billion per year in 2016 and 2017, according to the report. More fatal opioid overdoses. More than 1.2 million Canadians and Americans will die from opioid overdoses by 2029 if the epidemic is not tamed, a group of leading health experts wrote in a report published last week. 

Most of us have heard that drinking a glass of wine or having a beer each night might be good for our hearts, and our health and longevity. Well, a new study published in the journal PLOS Medicine suggests that might not be the case. German researchers studied over 4,000 adults and found no difference […] The post 96. A glass of wine each day might not improve your health appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Wondering how a plant-based diet might benefit your patients and the climate? We sit down with plant-based diet expert Dr Shireen Kassam to discuss the climate impact of diet, the evidence for a plant-based diet in reversing chronic diseases, and how we can discuss it with our patients.Links mentioned: https://plantbasedhealthprofessionals.com/ https://www.pcrm.org/ https://ourworldindata.org/food-choice-vs-eating-local?country=https://www.nationalfoodstrategy.org/ Important citations:Bodai, B.I. et al. (2017) ‘Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival', The Permanente Journal. doi: 10.7812/TPP/17-025. Budhathoki S, Sawada N, Iwasaki M, et al. (2019) 'Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality', JAMA Intern Med. Published online August 26. doi:10.1001/jamainternmed.2019.2806Coronary artery disease: The role of plant-based diets in coronary artery disease Diabetes:  Satija, A. et al. (2016) ‘Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies', PLoS Medicine. doi: 10.1371/journal.pmed.1002039Climate impacts: Scheelbeek P, Green R, Papier K, et al. (2020) 'Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies'. BMJ Open;10:e037554. doi:10.1136/ bmjopen-2020-037554 Willett, W. et al. (2019) ‘Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems', Lancet, 6736, pp. 3–49. doi: 10.1016/S0140-6736(18)31788-4.Changing food systems

I denne vægttabsspecial af sundhedsmagasinet går træningsfysiolog Henrik Duer bl.a. i dybden med: 1. Kan supermarkedernes tricks få os til at købe sundere ind? 2. Skal vi smide vægten ud og glemme alt om vægttab? 3. Giver intervalvægttab bedre resultater hos folk, der styrketræner Læserspørgsmål 1: er 1000 mg C-vitamin godt for senerne Læserspørgsmål 2: modvirker kolesterol-medicin muskelvækst? God fornøjelse Artikler der diskuteres: - PLOS Medicine | https://doi.org/10.1371/journal.pmed.1003729 September 7, 2021- - https://videnskab.dk/krop-sundhed/slip-hjernens-superkraefter-loes-glem-din-vaegt-og-fokuser-paa-sundhed-lyder-forskers - Med Sci Sports Exer. 2021 Aug 1;53(8):1685-1698

There are five Plasmodium species that cause malaria with the vast majority of reported cases being due to Plasmodium falciparum. Plasmodium vivax is the second most common reported cause of malaria. My guest today says P. vivax infections represent a major unrecognized burden on global health calling it "obscure and insidious" and we'll take a look at why he says this. Joining me today to discuss Plasmodium vivax, it's burden and a new study published in PLoS Medicine is Kevin Baird, PhD. Professor Baird is the head of the Eijkman-Oxford Research Unit in Jakarta, Indonesia and Professor of Malariology, Nuffield Department of Medicine, University of Oxford.

Le cholestérol est une molécule appartenant à la famille souvent désignée à tort sous le terme de graisse. Cette molécule, essentielle au fonctionnement de l'organisme et du cerveau peut aussi se révéler préjudiciable. En effet, une concentration importante du cholestérol dans le sang a été associé à un risque plus élevé de développer la maladie d'Alzheimer. Mais le lien entre les deux reste toujours incertain. Toutefois, certaines pistes pointent vers un potentiel effet des traitements anti-cholestérol. C'est pour tenter d'en apprendre davantage que des chercheuses et chercheurs étatsuniens, anglais, irlandais et néerlandais ont menés une étude en collaboration dont les résultats ont été publiés dans la revue scientifique Plos Medicine en mai 2021. See acast.com/privacy for privacy and opt-out information.

Newsletter: https://dralkapatel.com/mailinglist “How can we create more compassionate communities?” Season 7 Episode 7 My guest on this week's episode of The Lifestyle First Podcast is Dr Julian Abel Julian is a TEDx speaker with his talk, “Why Compassion Matters” and the Director of Compassionate Communities UK. We discuss defining compassion at a contextual level and including our good qualities of being human. We look at human brain structure – the reptilian brain, the mammalian brain and the pre-frontal cortical brain We explore social evolution, how survival evolved from being able to help each other and the evolutionary pressure of compassion. We look at survival of the fittest versus survival of the kindest We talk about swimming in a sea of compassion and all the ways this is readily expressed in our daily actions. We highlight the importance of interdependence and reciprocity. We reflect on self esteem and nourishing relationships through childhood to the present moment 1. The one question we discuss is “How can we create more compassionate communities.” 2. The two references we look at are: (i) My Octopus Teacher https://youtu.be/3s0LTDhqe5A (ii) Holt-Lunstad, J., et al. Social relationships an mortality risk – a metanalytic review. PLOS Medicine. 2010. 7(7) https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000316&mod=article_inline 3. The three actions to take are · Take time to recognise that you are already compassionate – find out where you are already swimming in the sea of compassion · Take little steps of compassion- what have you got that you can give · Go for the relationships. Which of these 3 actionable lifestyle tips will you implement? Leave your comments below. -x- Join The Lifestyle First Academy! Take the flagship course – Start Now: Transform your Lifestyle, Transform your Life https://dralkapatel.com/academy/ -x- DISCLAIMER: This content does not constitute or substitute personal one-to-one professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or health care professional with questions about your health. -x- Find Out More/Contact/Follow: Guest: Dr Julian Abel TEDx https://www.ted.com/talks/dr_julian_abel_why_compassion_matters?utm_campaign=tedspread&utm_medium=referral&utm_source=tedcomshare Website https://www.compassionate-communitiesuk.co.uk/ Social https://twitter.com/abelwords?lang=en Host Dr Alka Patel TEDx talk https://youtu.be/JpFLNk3_Qik Newsletter: https://dralkapatel.com/mailinglist Website: https://dralkapatel.com/ Social: LinkedIn https://www.linkedin.com/in/dralkapateluk/ YouTube: https://www.youtube.com/channel/UCaQrM4ryE0a38zqsednEppQ --- Send in a voice message: https://anchor.fm/dr-alka-patel/message

If the world is ever going to end hunger, ensure food security and embrace sustainable agriculture practices, we've got to invest more in agriculture. Particularly, in developing countries. Now, governments and international organizations do invest in agriculture of course, but less than in healthcare, for example. And we wondered why? It turns out it's not so much a question of why healthcare receives more funding, it's how such funds are raised and distributed that makes a difference.   In this podcast, we're going to explore findings from our new report on agricultural development financing and highlight some innovative practices from healthcare sector that could be used to boost resources for agriculture in low and middle income countries. Our guests are global health policy professor Gavin Yamey of the Duke University Center for Policy Impacting Global Health and global health financing and policy expert, Marco Schaeferhoff of Open Consultants.   Interview Summary Marco, in our report, we explore some of the reasons why ODA, official development assistance, increased so dramatically for healthcare. But first, could you help our listeners understand some of the big differences in development assistance for the health sector as compared to the agricultural sector? Great question. So, what I would say is that the sheer amount of financing, official development assistance, for health and for agriculture are vastly different. If you look at the last 10, 20 years, agriculture ODA rose a little bit in absolute terms but as a share of total ODA, it remains rather flat. It's about 4 percent of total ODA. In health, you have a completely different picture. After the year 2000 up until roughly 2012, there was an enormous growth in development assistance for health from about 12 billion up to even 36 billion in 2012. This era between 2000 and 2012 was called the golden age global health financing. Despite the fact that there is already so much development assistance for health, it's still growing. If you look at agriculture, this is a very different picture where you have maybe at 10 or 11 billion, and it's very likely that we will see a decline in 2020 due to the COVID crisis. In addition, the composition of agriculture ODA is also interesting. So if you look at the ODA provided by bilateral donor countries, like the US, or the UK, or Germany, about three quarters of all agriculture ODA in 2018 was bilateral ODA. In contrast, multilateral institutions, like the World Bank or EFR, only accounted for about a quarter. So, and relatively small share of all agriculture ODA. As a result of that, you have many small projects. So for example, the bilateral reported almost 14,000 aid activities for agriculture alone in 2018. And the average size of these projects and program was less than half a million. This is of course difficult from a recipient perspective, because you have many small projects which cause high transaction costs, and which are often also largely uncoordinated. So that's one thing. In addition, if you look at the distribution of ODA loans versus 48 grants, you can see that about 35 percent of all agriculture ODA came in loans, and 65 percent came in grants, in 2018 again. So, first of all compared to 2017 levels, grantage fell by about 8 percent. What is kind of interesting is that in the agriculture sector, multilateral funders tend to use loans but bilateral funders, primarily use grants. So what is striking is that in 2018, 80 percent of all multilateral agriculture ODA was provided by loans and only 20 percent in grants. The issue now compare this distribution with the health sector, you will see that exactly the opposite. So in health, about 80 percent of multilateral ODA comes in grants and only 20 percent in loans. What this shows is essentially that there is no large scale multi-lateral funder that provides grants for agriculture. So during the time period in which healthcare development aid exploded, governments were working towards the UN's millennium development goals or MDGs. Those goals created a focus for donor investment in low and middle income countries. And that's a good segue for my next question to Gavin. What can the agricultural development financing sector learn from the health financing sector? I think the health sector did very well on resource mobilization. Marco mentioned this term golden era where there was astonishing growth in health ODA. Really remarkable explosive growth, tripling of annual ODA for health. And it's probably no surprise that when you look at where that went to it was for the MDGs for health. Right? So, child health, maternal health and HIV AIDS, TB and malaria. And this explosive growth in ODA for health was targeted particularly to those three goals. And I think what that tells you is health did well at saying, "We need to mobilize and have a clear financing plan for these particular priorities." And that's what happened. How that happened is another lesson here for the ag dev sector. And that is, it was largely explained by the launch of new kinds of financing mechanisms. I think one of the things the health sector did well was to innovate in terms of the architecture of global health. So you started to see new entities forming that were mobilizing very large amounts of new financing. For example, the Global Fund to fight AIDS, tuberculosis and malaria, Unitaid – so-called innovative financing mechanisms innovative financiers that we're able to mobilize large amounts of new dedicated financing for HIV, TB, malaria, vaccine preventable diseases and so on. And it wasn't just through traditional means that ODA was mobilizing. If you take UNITAID, for example, it has raised most of its funding, which is for HIV, TB and malaria, through a solidarity air ticket tax. So in about 20 or 30 countries that are members of Unitaid, when you buy an airline ticket, the taxes placed on that ticket and it's used to fund Unitaid programs. And also a carbon tax. And I think the health sector has done well in using these new kinds of instruments: Airline solidarity, levies, vaccine bonds, for example, which turned long-term contributions by donors into immediately available cash. Advanced market commitments where agreements are made upfront, that if a global health technology is developed, they will be financing to buy it. So there's a range of innovative approaches that have been used in the health sector together with this sort of financing roadmap, a mobilization strategy, and a focus on multi-lateral rather than bilateral financing. All of which the ag dev sector I think could learn from. So in our report, we highlight several ways to boost agricultural donor support such as innovative financing mechanisms, reforming the aid architecture, coordinating investment through a financing roadmap and shifting more support to multilateral organizations that pool money such as the World Bank. Marco, do you have anything else to add to that list? Yes, I think it's a great list. Maybe some quick nuances to this. So, one example Gavin mentioned the very important new mechanisms, these were deliberately created as grants based mechanisms. So the Global Fund to fight AIDS, TB and malaria or Gavi, the Vaccine Alliance were grant-based. Because before in global health, when it came to multilateral health finances, what the community realized at that point was that loans might not be the right way to tackle these diseases, especially HIV. So that's important. The second thing is that the growth in global health financing, to some extent was also fueled by the anxiety of the HIV pandemic at that time. So there was a securitization of HIV, and the Global Fund, for example, was supposed to be an HIV fund first and foremost, but then malaria and TB was added. So I'm saying that because MDG5, which was maternal health, and MDG4, which was child health, was a little bit neglected. And there was a realization that there was a lot of funding for MDG6. And at around 2008, 2009 there was a big discussion and debate about how to increase ODA for maternal and child health. And in that context, there was a very concrete multi-stakeholder effort to coordinate the field, and to raise funding for these specific purposes. And that was a global strategy for women, children and adolescent health. And that was a really important document which also included key indicators and the whole community really surrounded, and it really helped to coordinate the field and to raise financing. So I think this is a very concrete example to Gavin's point. And then finally we believe in the health sector that is the investments in what we call global public goods investments for example, in data. Data or needs, results, financing best practices, knowledge distribution functions, research, technical innovations. So there were quite a lot of investment, insufficient investment, but still quite a lot of investment into such global public goods. And we feel that such investment paid off based on very concrete data to say, who's putting in money into global health at country level. What is the impact of an intervention? What is the benefit cost ratio of investing in health? So these kinds of data, metrics and research I think that was a very valuable investment. And to some extent, we also see this in other sectors but I would say the focus in health is really unprecedented and that is something that agriculture could also focus on more in the future. So Marco, I'm curious then, what are the barriers for the agricultural development financing sector to make those shifts, to try to emulate the health sector financing? So, I would say that overall there is a lot of potential for the agriculture sector to learn from health. Let me maybe just say that we do not want to idolize the health sector. It still has challenges, but I think it moved in the right direction in the past decade. Things like investments in global public goods, grant-based multi-laterals investments in new technologies and innovations, investments in data and metrics. All these things could be more emphasized in agriculture as well. In terms of barriers, it is true of course, that in health we have seen a number of huge crisis. Gavin and I mentioned the HIV AIDS crisis, or the West African Ebola crisis, that really helped to increase the amounts and development assistance for health substantially. So I think much of what we suggest in the report could be applied to the agriculture sector as well. It's probably true that in the health sector, the technological fixes might be a little bit more important. It's very hard to develop vaccines, it's hard to develop new drugs, it's hard to distribute them, but we have very good tools and to some extent we do not have that in agriculture. But I think there's still a lot of potential for R&D and innovations. In addition, I would say that the current context, because of the COVID crisis, we will see a decline in ODA overall, but certainly for agriculture and other areas. We will see to what extent of the health sector will be affected. It might well be the case that we see another increase in health ODA. But the current context is a little bit difficult. Another thing we found in our study is that there is quite a lot of fragmentation in the agriculture sector. So when it comes to coordination piece, that we suggested a concerted effort to finance agriculture, and that might be fairly hard to achieve simply because you have multiple bilaterals with different perspectives. I think if you look at the Europeans or the US, there is a difference in interests and perspectives. So that is something that would have to be figured out. We have few multilateral financers which sometimes collaborate with each other but often there is lack of foreign action. So I think these things make the reform of the global architecture a little bit difficult, but to be honest, 20 years ago we faced very similar issues in the health sector. Overall, I do think that what we suggest in terms of innovative financing mechanisms data, multilateral grant funds saying these broad directions should and can be taken on board by agriculture. Gavin turning to you, you talked a lot about innovative financing mechanisms in the health sector and how they could be applied to the agricultural development sector. I'm curious, what are typical barriers for setting up those types of innovative financing mechanisms that you could foresee? As the name suggests, innovative, it requires stakeholders to think beyond traditional sources, right? So it requires new ways of thinking. It requires some kind of demonstration project or some at least pathway to seeing how an innovative financing mechanism could work. So it's often difficult to pilot these large scale initiatives, you know, but at least showing proof of principle, showing the potential investment case can be very helpful. If you look at some of the innovative financing mechanisms that you could argue have been successful, like Unitaid use of an airline ticket tax and a carbon tax. Those are the two sources of financing that Unitaid has used to raise very large volumes of financing for HIV, TB, and malaria. They were actually able to quite quickly demonstrate, you know, how much money could be raised. And they are a very significant player now in the HIV, TB landscape. I think there is some skepticism around some of the less tried and true ways to raise money that are, you know, still being tested out, if you like. There's been lots of talk for example, about tourist taxes. If, for example, you're a tourist who goes to a malaria endemic region, there's a lot of talk of an innovative tourist tax. You ask that tourist to pay $5 or $10 to enter the country and use it for malaria control. I haven't seen those sorts of mechanisms take off yet. I know they were under consideration, for example for the Island of Zanzibar. And similarly, a lot of talk about using bonds, has been used successfully, I would argue in the vaccine space. And then the last point I would probably make is, in my mind the most innovative thing we could be doing for global health financing, certainly for mobilizing financing for international collective action and global public goods like pandemic preparedness or research and development for neglected and emerging infectious diseases, would actually be a new kind of global pooled fund or perhaps a global tax. We haven't really ever been able to go there, perhaps because of a general disquiet, a general lack of enthusiasm for a global tax. But I think post COVID-19, I don't really see how we can get away from the notion that each nation is going to contribute according to its means towards, you know, some kind of pooled fund going forward. And there may be that sort of conversation happening around agricultural development financing as well. Bios: Gavin Yamey MD, MPH, MA is the Director of the Center for Policy Impact in Global Health at Duke University. Yamey trained in clinical medicine at Oxford University and University College London, medical journalism and editing at the BMJ and public health at the London School of Hygiene and Tropical Medicine. He was Deputy Editor of the Western Journal of Medicine, Assistant Editor at the BMJ, a founding Senior Editor of PLOS Medicine, and the Principal Investigator on a $1.1 million grant from the Bill & Melinda Gates Foundation to support the launch of PLOS Neglected Tropical Diseases. In 2009, he was awarded a Kaiser Family Mini-Media Fellowship in Global Health Reporting to examine the barriers to scaling up low cost, low tech health tools in Sudan, Uganda and Kenya. Marco Schäferhoff, PhD, is co-founder of Open Consultants. He combines over 15 years of management and consulting experience with in-depth expertise in global health financing and policy. An expert in development economics, Marco has led numerous projects involving benefit-cost analysis. He has worked in a range of development sectors, including health, education, nutrition, agriculture, and energy. Marco served as a member of The Lancet Commission on Investing in Health and has published widely on development financing and policy. He holds an advanced degree in Politics and a PhD in Political Science.    

Theme: POCUS. Participants: Oliver Archer (ED resident and previous cardiac sonographer), Hung Diep (ED advanced trainee), Dr Richard McNulty, Dr Kenny Yee, Dr Pramod Chandru, Kit Rowe, Shreyas Iyer, Caroline Tyers and Samoda Wilegoda Mudalige.Discussion 1:Presenter - Oliver Archer.Starting - 02:00. Atkinson, P., Beckett, N., French, J., Banerjee, A., Fraser, J., & Lewis, D. (2019). Does Point-of-care Ultrasound Use Impact Resuscitation Length, Rates of Intervention, and Clinical Outcomes During Cardiac Arrest? A Study from the Sonography in Hypotension and Cardiac Arrest in the Emergency Department (SHoC-ED) Investigators. Cureus. https://doi.org/10.7759/cureus.4456.Take-Home Points: This study showed that visualizing cardiac activity on ultrasound resulted in increased duration and effort of resuscitation, and was associated with improved clinical outcomes.  It is difficult to know whether the improved clinical outcomes were secondary to increased resuscitation efforts or due to identification (with ultrasound) of those with a better prognosis.  Ultimately, ultrasound should be used as an adjunct to your clinical decision-making, but should not get in the way of the established standard ALS protocol.  The COACHRED protocol (referenced below) assists in incorporating POCUS into the arrest algorithm. Discussion 2:Presenter - Hung Diep.Starting - 29:10.Daley, J., Dwyer, K., Grunwald, Z., Shaw, D., Stone, M., & Schick, A. et al. (2019). Increased Sensitivity of Focused Cardiac Ultrasound for Pulmonary Embolism in Emergency Department Patients With Abnormal Vital Signs. Academic Emergency Medicine, 26(11), 1211-1220. https://doi.org/10.1111/acem.13774.Take-Home Points: This study shows that focused cardiac ultrasound (FOCUS): involving right ventricular dilation, McConnell's sign, septal flattening, tricuspid regurgitation, and tricuspid annular plane systolic excursion (TAPSE), maybe a useful adjunct in the workup of patients with a high pre-test probability of PE. The most sensitive component of the FOCUS was TAPSE.  The most specific components of the FOCUS were McConnell's sign and septal flattening.  However, it is important to remember that illnesses associated with chronic right heart strain such as COPD would also yield a positive FOCUS. At this stage, there is not enough evidence for FOCUS in diagnosing PE to alter clinical decision-making.  Discussion 3:Presenter - Pramod Chandru.Starting - 01:03:35.  Chartier, L., Bosco, L., Lapointe-Shaw, L., & Chenkin, J. (2016). Use of point-of-care ultrasound in long bone fractures: a systematic review and meta-analysis. CJEM, 19(2), 131-142. https://doi.org/10.1017/cem.2016.397Take-Home Points: This study looked at the use of POCUS to assist with both the diagnosis and reduction of long bone fractures (radius, ulna, humerus, tibia, fibula, and femur).  POCUS use had reasonable sensitivity and specificity in the diagnosis of fractures, particularly paediatric forearm fractures and adult ankle fractures - however, it may not provide all the information required regarding a fracture once identified.  In the absence of fluoroscopy, using POCUS to delineate the satisfactory nature of a reduction in ED (such as of the wrist) may reduce the risks associated with recurrent reductions and the need for operative fixation, however, further research with randomized controlled trials is needed. All in all, it is hard to see how ultrasound would replace x-ray as the imaging modality of choice for fractures, but there is an argument to be made for the use of ultrasound in assessing for the adequacy of reduction particularly in specific populations and this would be an interesting area for future studies.  Interlude Segment:Starting - 56:10.Ioannidis, J. (2005). Why Most Published Research Findings Are False. PLoS Medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124.Other References:Finn, T., Ward, J., Wu, C., Giles, A., & Manivel, V. (2019). COACHRED: A protocol for the safe and timely incorporation of focused echocardiography into the rhythm check during cardiopulmonary resuscitation. Emergency Medicine Australasia, 31(6), 1115-1118. https://doi.org/10.1111/1742-6723.13374.Credits:The discussions were mediated by ED consultant and ultrasound guru Dr Kenny Yee, ED consultant and clinical toxicologist Dr Richard Mc Nulty, and ED consultant Dr Pramod Chandru.This episode was produced by the ­­­­Emergency Medicine Training Network 5 with the assistance of Dr Kavita Varshney, Deepa Dasgupta, Cynthia De Macedo Franco, and Paul Scott.Music/Sound Effects Another Time by LiQWYD | https://www.liqwydmusic.com, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US.  Cross Over by Sapajou | https://soundcloud.com/sapajoubeats, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US Esperanza by Roa Music | https://soundcloud.com/roa_music1031, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US Medical Examination by MaxKoMusic | https://maxkomusic.com/, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution-ShareAlike 3.0 Unported, https://creativecommons.org/licenses/by-sa/3.0/deed.en_US.  Mega Epic by Alexander Nakarada | https://www.serpentsoundstudios.com, Music promoted by https://www.free-stock-music.com, Attribution 4.0 International (CC BY 4.0), https://creativecommons.org/licenses/by/4.0/ Nightswim by Scandinavianz | https://soundcloud.com/scandinavianz, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US. Piano Rock Instrumental by Hyde - Free Instrumentals | https://soundcloud.com/davidhydemusic, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US. Ragga Groove by Peyruis | https://soundcloud.com/peyruis, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US.  Sea Current by Vlad Gluschenko | https://soundcloud.com/vgl9, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US Smile by LiQWYD | https://www.liqwydmusic.com, Music promoted by https://www.free-stock-music.com, Creative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US. Sound effects from https://www.free-stock-music.com. Wasting Time by Sapajou & Yorgo H | https://soundcloud.com/sapajoubeats, Music promoted by https://www.free-stock-music.comCreative Commons Attribution 3.0 Unported License, https://creativecommons.org/licenses/by/3.0/deed.en_US.  ~Thank you for listening!Please send us an email to let us know what you thought.You can contact us at westmeadedjournalclub@gmail.com.See you next time,Caroline, Kit, Pramod, Samoda, and Shreyas.

Este podcast é oferecido por HiDoctor – o software médico mais usado em consultórios e clínicas no país. O resumo da semana de 01/03 a 05/03 traz as seguintes publicações: - Gel de dextrose oral para prevenção da hipoglicemia neonatal não reduziu a admissão na UTI neonatal em bebês em risco, mas reduziu a hipoglicemia (PLOS Medicine). - Consumo de ovo e colesterol foi associado a maior mortalidade por todas as causas, por doença cardiovascular e por câncer (PLOS Medicine). - Pesquisa aponta mudanças de tendências nas causas predominantes de morte em indivíduos com e sem diabetes de 2001 a 2018 (The Lancet Diabetes & Endocrinology). - Glicemia materna e IMC são os principais fatores de risco modificáveis para evitar resultados adversos na gravidez de gestantes com diabetes tipo 1 ou tipo 2 (The Lancet Diabetes & Endocrinology). - Indivíduos sedentários estão em risco aumentado de infarto do miocárdio fatal (European Journal of Preventive Cardiology). - Mais de 50% dos pacientes com COVID-19 grave desenvolvem danos cardíacos subsequentes (European Heart Journal). - Estudo identificou sintomas neuropsiquiátricos associados à doença de pequenos vasos cerebrais (The Lancet Psychiatry). - Prevenção da anemia por deficiência de ferro em bebês e crianças pequenas: artigo de revisão do Pediatric Research (Pediatric Research). - O microbioma intestinal modula a associação protetora entre uma dieta mediterrânea e o risco de doença cardiometabólica (Nature Medicine). Veja mais notícias em news.med.br.

Citation:Ioannidis, John PA. "Why Most Published Research Findings Are False." PLoS Medicine 2.8 (2005): e124.Link:https://dx.plos.org/10.1371/journal.pmed.0020124

Michael Westerhaus (@socmedmjw) teaches the history of social medicine and what social medicine means. He explains the difference between social medicine and public health, the value of storytelling and social position in medicine, the relationship between inequality and health, and addresses if it is right for healthcare practitioners to "get political." Michael Westerhaus MD is a primary care physician for refugees at the Center for International Health in St. Paul, Minnesota. He is also an assistant professor at the University of Minnesota and an active social medicine educator with SocMed and the Social Medicine Consortium. His recommended resources: 1. Porter, Dorothy. 2006. “How Did Social Medicine Evolve, and Where Is It Heading?” PLoS Medicine 3(10): e399. Full text. 2. Fanon, Frantz. 1994. “Medicine and Colonialism.” In: A Dying Colonialism. Grove/Atlantic Press. PDF. (MR Press is rights-holder and has approved this usage). 3. Anderson, Smith, and Sidel. 2005. What is Social Medicine? Monthly Review. Full text.

  Vidcast:  https://youtu.be/Cx1EWDS3Cok   Most women are counseled to try a vaginal delivery following a previous Caesarian section (VBAC).  The latest evidence from the University of Oxford questions the wisdom of that recommendation.   More than 74,000 Scottish births over a 13 year period show that a VBAC is associated with a 7 fold higher risk of a uterine rupture, a 3 fold  higher risk of surgical injury, and a two-fold higher risk of sepsis and blood transfusion.  There is also a greater risk of stillbirth, a NICU admission, and a need for neonatal resuscitation.   If you’ve had a C-section and your OB is recommending a vaginal delivery, question carefully whether that choice is right for you.   Kathryn E. Fitzpatrick, Jennifer J. Kurinczuk, Sohinee Bhattacharya, Maria A. Quigley. Planned mode of delivery after previous cesarean section and short-term maternal and perinatal outcomes: A population-based record linkage cohort study in Scotland. PLOS Medicine, 2019; 16 (9): e1002913 DOI: 10.1371/journal.pmed.1002913   #Csection #VBAC #vaginaldelivery  

Jerm — Professor John Nicholls is a Clinical Professor in Pathology at the University of Hong Kong. His work on SARS and avian influenza has been published in prestigious journals such as Lancet, PLOS Medicine and Nature Medicine. Full conversation

In yesterday's budget, the provincial government revealed they will be applying the provincial sales tax (7%)  to carbonated sugary drinks. So what this means is that a $2 can of pop will cost 14 cents more after July 1st.  The government projects the tax will generate $27 million of revenue in 2020, and then $37 million of revenue in 2021.   A 2016 study published in PLoS Medicine suggested that a 10% excise tax on soda "could prevent 189,300 new cases of Type 2 diabetes, 20,400 strokes and heart attacks, and 18,900 deaths among adults 35 to 94 years old" over a ten-year period. The study also included that "the reductions in diabetes alone could yield savings in projected healthcare costs of $983 million." A 2017 study in the Journal of Nutrition found a 6.3% reduction in soft drink consumption, with the greatest reductions "among lower-income households, residents living in urban areas, and households with children.  We also found a 16.2% increase in water purchases that was higher in low- and middle-income households, in urban areas, and among households with adults only."   Guest: Claire Allen  CKNW Contributor

CHAPTER 1

Physics usually gets the credit for grand unifying theories and the search for universal laws…but looking past the arbitrary boundaries between the sciences, it’s just as true that ecological research reveals deep patterns in the energy and information structures of our cosmos. There are profound analogies to draw from how evolving living systems organize themselves. And at the intersection of biology and physics, epidemiology and economics, new strategies for conservation and development emerge to guide us through the needle’s eye, away from global poverty and ecological catastrophe and toward a healthier and wealthier tomorrow…This week’s guest is SFI External Professor Andy Dobson of Princeton University, whose work focuses on food webs, parasites, and infectious diseases to help us understand and better manage the complexities of climate change and urban growth, human-wildlife interactions, and the spread of pathogens. In this episode we talk about how network structures can inhibit or accelerate disease transmission, the link between biodiversity and economic growth, and how complex systems thinking leads to better wildlife conservation.For transcripts, show notes, research links, and more, please visit complexity.simplecast.com.If you enjoy this podcast, please help us reach a wider audience by leaving a  review at Apple Podcasts, or by sharing the show on social media. Thank you for listening!Visit our website for more information or to support our science and communication efforts.Join our Facebook discussion group to meet like minds and talk about each episode.Andy’s WebsiteAndy’s Google Scholar PagePodcast Theme Music by Mitch Mignano.Follow us on social media:Twitter • YouTube • Facebook • Instagram • LinkedIn

Professor Zaheer-Ud-Din Babar is a Professor in Medicines and Healthcare at the Department of Pharmacy, School of Applied Sciences at the University of Huddersfield. We were extremely proud to welcome him on to the podcast to discuss his remarkable new book which is an encyclopaedia of pharmacy. Professor Babar is globally recognised for his research in pharmaceutical policy and practice, including quality use of medicines, clinical pharmacy practice, access to medicines and issues related to pharmacoeconomics. Previously he was the Head of Pharmacy Practice at School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. A pharmacist by training and a PhD in pharmacy practice, Dr Babar is the recipient of the prestigious “Research Excellence Award” from the University of Auckland. He has active research collaborations and linkages with the World’s leading Universities such as Boston University School of Public Health, Harvard Medical School, Austrian Health Institute, University of Auckland, Monash University and with the University of Sydney. He has published over 100 papers including in high impact journals such as PLoS Medicine and the Lancet Oncology. Dr Babar has acted as an advisor for World Health Organization, Health Action International, International Union Against Tuberculosis and Lung Disease, World Bank, International Pharmaceutical Federation (FIP) and for the Pharmaceutical Management Agency of New Zealand. His recent work also includes a number of high-quality books including "Economic evaluation of pharmacy services", ”Pharmaceutical prices in the 21st century”, and “ Pharmacy Practice Research Methods”. Published by Elsevier and Adis/Springer, the work is used in curriculum design, policy development and for referral all around the globe. If you prefer to never miss an episode you can subscribe on your preferred podcast platform. Just click on the links below to get going. Click here to subscribe on Anchor Click here to subscribe on Apple Podcasts Click here to subscribe on Google Podcasts Click here to subscribe on Spotify Click here to subscribe on Breaker Click here to subscribe on Overcast Click here to subscribe on Pocketcast Click here to subscribe on Radio Public Click here to subscribe on Stitcher

Our guest today is Dr. John Ioannidis, a Stanford professor who has been described by “BMJ” as “the scourge of sloppy science.” Atlantic magazine has gone so far as to refer to him as one of the world’s most influential scientists. John is renowned for his 2005 paper, “Why Most Published Research Findings Are False,” which has been viewed more than 2.5 million times and is the most citied article in the history of the journal PLoS Medicine. He has authored nearly a thousand academic papers and has served on the editorial board of 30 top-tier journals. At Stanford, John is a professor of medicine, of health research and policy, and of biomedical data science in the school of medicine as well as a professor of statistics in the school of humanities and sciences. He is the co-director of the university’s Meta-Research Innovation Center and the former director of the Stanford Prevention Research Center. In today’s wide-ranging interview, John talks about: [00:07:43] What led him to begin questioning the reliability of medical research during his residency at Harvard. [00:12:03] His 2005 paper, “Why Most Published Research Findings Are False.” [00:26:27] How a major issue facing science is a lack of replication. [00:30:51] Which studies are worse, nutritional studies or drug studies. [00:38:25] If it’s possible to remove sampling biases like the healthy user bias. [00:46:50] The need for scientists to disclose their personal dietary biases as well as their personal diets when publishing research findings. [00:52:40] His recent paper, “Evidence Based Medicine Has Been Hijacked,” which argues that vested interests have transformed clinical medicine into something that resembles finance-based medicine. [00:55:36] The impact that funding pressure is having on the veracity of research being done today. [01:08:42] The need for future research to be designed by scientists without vested interests. [01:14:58] The ways John would fix the system if he had magic wand. [01:18:42] And as a bonus, John reads an excerpt from his latest book. Show notes: [00:02:37] Dawn begins the interview asking John about being born in New York but raised in Athens. [00:03:54] John talks about how his parents were physicians and researchers and how they instilled in him a love for mathematics at an early age. [00:05:26] Dawn asks John about winning the Greek Mathematical Society’s national award when he was 19 years old. [00:06:23] John talks about his decision to go to medical school and to attend Harvard. [00:07:43] Ken mentions that John began questioning the reliability of medical school during his residency at Harvard, and asks John to talk about his interest in an “evidence-based medicine” movement that was gathering momentum at the time. [00:08:47] Dawn asks John about his work with the late Tom Chalmers, who played a major role in the development of randomized controlled trials. [00:09:58] John talks about returning to Greece to take a position at the University of Ioannina. [00:12:03] John talks about his 2005 paper “Why Most Published Research Findings Are False,” which became the single most-cited and downloaded paper in the history of the journal PLoS Medicine. [00:15:32] Dawn mentions that when the paper came out, it was theoretical model. She asks John to talk about how now there are a number of studies pointing out problems with preclinical research on drug targets. [00:17:34] Dawn asks John about his decision to leave the University of Ioannina to take a position at Stanford University. [00:21:02] Dawn asks John for his thoughts on ways to improve the peer-review process. [00:24:09] John talks about how he and his colleagues have found that most medical information that doctors rely on is flawed. [00:26:27] Dawn points out that a major issue facing science is a lack of replication. She talks about how funding for repeat studies is hard to come by and that ma...

En el episodio de hoy comentamos un articulo recientemente publicado en PLOS Medicine sobre la transmisión sexual de Zika    Referencia: Michel Jacques Counotte y colaboradores. Sexual transmission of Zika virus and other flaviviruses: A living systematic review. PLOS Med.  Julio 24, 2018.   La Frase de la Semana:   Esta semana la tomamos de Samuel Johnson. Samuel Johnson, apodado Dr. Johnson, (nacido el 18 de septiembre de 1709 en Lichfield, Inglaterra y fallecido el 13 de diciembre de 1784 en Londres) fue crítico, biógrafo, ensayista, poeta y lexicógrafo inglés. Esta considerado como una de las más grandes figuras de La vida y las letras inglesas del siglo XVIII.   La frase dice:  “Se puede tener por compañera a la fantasía, pero se debe tener como guía a la razón”  

Series two of The Recommended Dose kicks off with polymath and poet, Dr John Ioannidis. Recognised by The Atlantic as one the most influential scientists alive today, he's a global authority on genetics, medical research and the nature of scientific inquiry itself – among many other things. A professor at Stanford University, John has authored close to 1,000 academic papers and served on the editorial boards of 30 of the world's top journals. He is best known for seriously challenging the status quo. His trailblazing 2005 paper 'Why Most Published Research Findings Are False' has been viewed over 2.5 million times and is the most cited article in the history of PLoS Medicine. In it, he argues that most medical research is biased, overblown or simply wrong. Here, he talks to Ray about the far-reaching implications of these findings for people both inside and outside the world of health. While most closely associated with exploring cutting-edge conundrums across science, genomics and even economics, John is also something of a humanist. He'd be right at home with the philosophers of ancient Greece, seeking as he does to find answers to the big questions of the day in science and medicine, as well as in nature and narratives. A voracious reader himself, John has a lifelong love of ‘swimming in books' and has penned seven literary works of his own in Greek – two of which have been nominated for prestigious literary prizes. And fittingly, he finds inspiration for his myriad of multi-disciplinary pursuits on Antipaxi, one of Greece's most beautiful and secluded islands. He shares some of his distinctive logic, reason - and even a little of his poetry - on this very special episode of The Recommended Dose, produced by Cochrane Australia and co-published with the BMJ. You'll find our show notes and a full transcript of the show at http://australia.cochrane.org/trd

Series two of The Recommended Dose kicks off with polymath and poet, Dr John Ioannidis. Recognised by The Atlantic as one the most influential scientists alive today, he's a global authority on genetics, medical research and the nature of scientific inquiry itself – among many other things. A professor at Stanford University, John has authored close to 1,000 academic papers and served on the editorial boards of 30 of the world's top journals. He is best known for seriously challenging the status quo. His trailblazing 2005 paper 'Why Most Published Research Findings Are False' has been viewed over 2.5 million times and is the most cited article in the history of PLoS Medicine. In it, he argues that most medical research is biased, overblown or simply wrong. Here, he talks to Ray about the far-reaching implications of these findings for people both inside and outside the world of health. While most closely associated with exploring cutting-edge conundrums across science, genomics and even economics, John is also something of a humanist. He'd be right at home with the philosophers of ancient Greece, seeking as he does to find answers to the big questions of the day in science and medicine, as well as in nature and narratives. A voracious reader himself, John has a lifelong love of ‘swimming in books' and has penned seven literary works of his own in Greek – two of which have been nominated for prestigious literary prizes. And fittingly, he finds inspiration for his myriad of multi-disciplinary pursuits on Antipaxi, one of Greece's most beautiful and secluded islands. He shares some of his distinctive logic, reason - and even a little of his poetry - on this very special episode of The Recommended Dose, produced by Cochrane Australia and co-published with the BMJ. You'll find our show notes and a full transcript of the show at http://australia.cochrane.org/trd

The Dean for the National School of Tropical Medicine, Baylor College of Medicine, Dr Peter Hotez is concerned about measles in his state of Texas, so much that he is raising the alarm by predicting a measles outbreak could happen as early as the winter or spring of 2018. In an article published in PLoS Medicine last fall, Hotez writes: Measles vaccination coverage in certain Texas counties is dangerously close to dropping below the 95% coverage rate necessary to ensure herd immunity and prevent measles outbreaks. He tells me during the interview, “Something awful is happening in Texas,” Dr Hotez said. “Texas is becoming the epicenter of what looks like, some neo-antivaxxer movement”. There have been some 50,000 nonmedical or “reasons of conscience” exemptions to school immunization laws, almost double the number of exemptions in 2010.

Dr. William Uttal first appeared on the Brain Science Podcast back in 2012. He was a long time critic of over reliance of certain types of brain imaging, especially fMRI, in cognitive neuroscience. Sadly, he died in February 2017, so in his honor I am replaying that original interview. The points he made are just as relevant now as they were 5 years ago. Links and References Uttal, W. R. (2011) Mind and Brain: A Critical Appraisal of Cognitive Neuroscience. Uttal, W. R. (2009) Neuroscience in the Courtroom: What Every Lawyer Should Know About the Mind and the Brain. Ihnen, S. K. Z., Church, J. A.. Petersen, S. E., & Schlaggar, B.L. (2009) Lack of generalizability of sex difference in the fMRI Bold Activity associated with language processes in adults. NeuroImage, 45, 1020-1032. Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8): e124. BSP 46: How fMRI works. Announcements You can now record your voice feedback at http://speakpipe.com/docartemis. Brain Science is now 100% listener supported. You can support the show via direction donations, Premium Subscription, or Patreon.  I am planning to attend this year's Society of Neuroscience Meeting, which is being held in Washington DC November 11-15, 2017. Please email at brainsciencepodcast@gmail.com if you are going to be in Washington during those dates. If there is enough interest I will arrange a listener meet-up. I am also in the early stages of planning a trip to Australia in 2018 and would love to hear from Australian listeners for ideas and advice, including leads on speaking opportunities. Please send email feedback to brainsciencepodcast@gmail.com. Please visit http://brainsciencepodcast.com for more episodes and transcripts.

One day, coffee is good for you; the next, it's not. And it seems that everything you eat is linked to cancer, according to research. But scientific studies are not always accurate. Insufficient data, biased measurements, or a faulty analysis can trip them up. And that's why scientists are always skeptical. Hear one academic say that more than half of all published results are wrong, but that science still remains the best tool we have for learning about nature. Also, a cosmologist points to reasons why science can never give us all the answers. And why the heck are scientists so keen to put a damper on spontaneous combustion? Studies discussed in this episode: Chocolate and red wine aren't good for you after all The Moon is younger than we thought Guests: John Ioannidis – Professor of medicine, health research and policy, and statistics, and co-director of the Meta-Research Innovation Center at Stanford University. His paper, “Why Most Published Research Findings are False,” was published in PLoS Medicine. Marcelo Gleiser – Physicist and astronomer at Dartmouth College, author of The Island of Knowledge: The Limits of Science and the Search for Meaning Joe Schwarcz – – Professor of chemistry and Director of the Office for Science and Society, McGill University, Montreal and author of Is That a Fact?: Frauds, Quacks, and the Real Science of Everyday Life First released June 16, 2014. Learn more about your ad choices. Visit megaphone.fm/adchoices

ENCORE  One day, coffee is good for you; the next, it’s not. And it seems that everything you eat is linked to cancer, according to research. But scientific studies are not always accurate. Insufficient data, biased measurements, or a faulty analysis can trip them up. And that’s why scientists are always skeptical. Hear one academic say that more than half of all published results are wrong, but that science still remains the best tool we have for learning about nature. Also, a cosmologist points to reasons why science can never give us all the answers. And why the heck are scientists so keen to put a damper on spontaneous combustion? Studies discussed in this episode: Chocolate and red wine aren’t good for you after all The Moon is younger than we thought Guests: John Ioannidis – Professor of medicine, health research and policy, and statistics, and co-director of the Meta-Research Innovation Center at Stanford University. His paper, “Why Most Published Research Findings are False,” was published in PLoS Medicine. Marcelo Gleiser – Physicist and astronomer at Dartmouth College, author of The Island of Knowledge: The Limits of Science and the Search for Meaning Joe Schwarcz – – Professor of chemistry and Director of the Office for Science and Society, McGill University, Montreal and author of Is That a Fact?: Frauds, Quacks, and the Real Science of Everyday Life First released June 16, 2014.

Twee belangrike studies wat vandeesweek vrygestel is, beklemtoon weer eens die waarde van oefening om die aftakeling van die brein te vertraag. Die eerste studie wat in Australië gedoen is, en wat in die aanlyn weergawe van Plos Medicine gepubliseer is, het bevind dat rekenaargefundeerde breinoefening vir bejaardes as sterk teenvoeter kan dien teen demensie. Die ander studie wat in Swede gedoen is, se bevindings is dat matige oefening jou kanse om Parkinson se siekte te kry, met 43% verminder. Anita Visser praat hieroor met ons wetenskapkorrespondent, George Claassen.

London School of Hygiene and Tropical Medicine Audio News: Migrant Health: A Key Issue For Global Health LONDON—Good health care for the one billion migrants around the world is vital if global health for all is to be achieved and maintained, according to Cathy Zimmerman of the Gender Violence and Health Centre at The London School of Hygiene & Tropical Medicine — author of the first article in a series devoted to Migration And Health in the medical journal: PLoS Medicine, for which she is one of the editors.

HEIDELBERG—High maternal mortality rates in Africa could be reduced if all women delivered in a setting where a midwife or doctor can provide skilled care in case of complications. However, millions of women in Africa give birth at home. Two key factors influencing choice of delivery place are the distance from women’s homes to the closest health centre, and the quality of emergency obstetric care provided there, according to a study in rural Zambia published in the journal: PLoS Medicine. Sabine Gabrysch from the London School of Hygiene and Tropical Medicine and the Institute of Public Health in Heidelberg discusses her findings and their implications for reducing maternal mortality.

Dr. Larry Peiperl is an Associate Clinical Professor of Medicine at UCSF and has been practicing internal medicine at safety-net clinics in San Francisco and New York City for 15 years. He has worked on clinical trials in HIV prevention and treatment. He serves as an editor for the open access journal PLoS Medicine and as medical consultant at Glide Health Services in the Tenderloin. He received the bodhisattva precepts in 2005. Support the show______________ To participate live and be notified of upcoming speakers in advance, please Like us on Facebook (https://www.facebook.com/gaybuddhistfellowship) or visit https://gaybuddhist.org/calendar/ To support our efforts to share these talks with LGBTQIA audiences worldwide, please visit www.GayBuddhist.org.There you can: Donate Learn how to participate live Find our schedule of upcoming speakers Join our mailing list or discussion forum Enjoy many hundreds of these recorded talks dating back to 1996 CREDITSAudio Engineer: George HubbardProducer: Tom BrueinMusic/Logo/Artwork: Derek Lassiter

Chronic diseases such as heart disease and diabetes are now so common in poor countries that they threaten the Millennium Development Goals for achieving significant progress on infectious diseases, and on child and maternal mortality by 2015. According to a report by scientists from London, Oxford and San Francisco, published in the journal PLoS Medicine, non–communicable diseases — common in rich countries — are now also taking their toll in poor countries, and — along with HIV — undermining the goals. Co-author, Martin McKee of the London School of Hygiene and Tropical Medicine, discusses the findings.

Dr. Tedd Mitchell, president of Cooper Clinic, discusses the United Kingdom study Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study reported in PLoS Medicine http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050012.  Researchers examined the prospective relationship between lifestyle and mortality in a prospective population study of 20,244 men and women aged 45 - 79, and found that four healthy lifestyle habits resulted in participants living an average of 14 years longer than those who didn't practice any of the four lifestyle habits. We also give the calculation for Body Mass Index (BMI), http://www.nhlbisupport.com/bmi/, and explain the categories.

Audio Journal of Medicine, August 9th 2007 Tuberculosis: Non-Adherence to Treatment is a Major Obstacle to Therapy Success REFERENCE: PLoS Med 4(7):e238. doi:10.1371/journal.pmed.0040238 SIMON LEWIN, London School of Hygiene and Tropical Medicine Non-adherence is a big factor reducing the efficacy of tuberculosis treatment according to a review of research released by the Public Library of Science's online medical journal, PLoS Medicine. The article suggests that more needs to be done to resolve barriers to therapy compliance in order to help reduce the global burden of tuberculosis. Nicola Solomon interviewed Simon Lewin.

Guest: Jonathan Sheldon, JD Host: Shira Johnson, MD A recent study published in PLOS Medicine went further than just giving political opinions when the authors researched the techniques used in lethal injection from two US states and concluded that these protocols may not reliably affect death through the mechanism intended.