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2 episodes with l arginine
2 episodes with l arginine
2 episodes with l arginine
Note: This episode originally aired in November 2021. Find out what Dr. Lipman and Dr. Rountree have to say about the rise of blood pressure in U.S. adults, hypertension symptoms, and how to maintain a healthy lifestyle for your heart. During this episode you'll learn about: High blood pressure as a lifestyle issue [1:54] Modern society and high blood pressure [2:20] Influence of western diet [3:05] Lifestyle factors for high blood pressure [4:08] Insulin resistance and metabolic syndrome [5:00] Salt sensitivity [5:47] Diet and high blood pressure [6:47] Stress and high blood pressure [7:29] Lack of sleep and exercise [8:00] What to do about high blood pressure [8:36] Addressing lifestyle issues [8:48] Consequences of high blood pressure [10:48] Symptoms [11:20] Measuring blood pressure [12:20] Supplements [13:30] Fish oil [14:48] Methyl-Guard [15:08] Olive oil and olive leaf [18:08] Questions for the community [20:00] How does blood pressure work? [20:20] Understanding systolic and diastolic numbers [20:30] Hypertension [22:27] What to look for if you have high blood pressure [22:48] How can I lower blood pressure immediately? [22:43] Why is blood pressure called hypertension? [25:12] Does blood pressure vary by age? [26:02] Blood pressure going up with age [26:26] What is the best kind of yoga for dealing with blood pressure? [27:06] Why does anxiety increase blood pressure? [29:11] Stress chemicals [29:20] How to maintain healthy blood pressure [31:00] Understanding low blood pressure [32:15] Products mentioned in this episode: Methyl-Guard®, L-Arginine, PolyResveratrol-SR®, CoQ10, Magnesium Bisglycinate, Berberine, Super EPA Pro Resources to topics mentioned in this episode: Nutrition For Healthy Blood Vessel Elasticity The Benefits of Healthy Blood Vessels What's the Connection: Understanding How Weight Affects Blood Fats Metabolic Syndrome Guide Subscribe to More Content Subscribe to the show wherever you listen to podcasts so you never miss an episode. You can also learn more about the topics in the episode by checking out the latest news, videos, and stories on Thorne's Take 5 Daily blog.
Audio Siar Keluar Sekejap episod 137 yang merupakan episod terahir bagi tahun 2024 antara lain membincangkan mengenai ura-ura kemasukan Tengku Zafrul Aziz ke dalam Parti Keadilan Rakyat (PKR) dan pelantikan Tun Musa Aman sebagai TYT Yang di-Pertua Negeri Sabah. Episod ini turut membincangkan mengenai penubuhan Pejabat Kecerdasan Buatan Kebangsaan (NAIO) dan pelancaran Panduan Belanjawanku 2024/2025 oleh Kumpulan Wang Simpanan Pekerja (KWSP). Dalam segmen terakhir, kedua-dua hos membuat refleksi perjalanan Keluar Sekejap sepanjang tahun 2024. Episod 137 ini dibawakan oleh GK Bio International. Dapatkan GKB Eurycozin, satu-satunya formulasi Bio-optimised 3Plus dengan Tongkat Ali (ekstrak herba tradisional); L-Arginine & L-Carnitine (asid amino) serta Zinc Yeast (mineral) untuk meningkatkan tenaga dan keharmonian keluarga. GKB Eurycozin mendapat kelulusan KKM dan disahkan halal oleh JAKIM. Bagi yang berminat menaja episod Keluar Sekejap untuk 2024, boleh hubungi +601119191783 atau emel kami di tajaan.ks@gmail.com.
Explore effective strategies for enhancing recovery post-surgery through dietary adjustments and targeted supplements. 5 KEY TAKEAWAYS 1.Pre and Post-Surgery Nutrition: Changing your diet before and after surgery can significantly impact your recovery speed and quality. 2.Importance of Liver Health: Supporting your liver is crucial as it processes medications and helps in detoxifying your body post-surgery. 3.Benefits of Supplements: Specific supplements like Vitamin C, L-Arginine, and L-Glutamine can enhance wound healing and reduce recovery time. 4.Red Light Therapy: Utilizing red light therapy can aid in healing and potentially reduce scarring post-surgery. 5.Soft Tissue Therapy: Engaging in soft tissue therapy can help manage and minimize post-surgical scarring and improve flexibility. FEATURED PRODUCT Liver Boost and Berberine by MSW Nutrition are designed to support metabolic health, crucial for anyone recovering from surgery. These supplements aid in liver function, helping to process medications and reduce inflammation, which is essential for a smooth recovery. visit www.mswnutrition.com to learn more TIMESTAMPS 00:00 START: Introduction to surgery recovery and the importance of preparation. •01:00: Discussing the critical role of diet in surgery recovery. •02:00: The benefits of adjusting your diet pre-surgery. •03:00: How liver health impacts recovery and the importance of supporting the liver with Liver Boost. •05:00: The effectiveness of red light therapy in post-surgery care. •06:00: Exploring soft tissue therapy as a method to enhance recovery post-surgery. •07:00: The role of dietary changes in reducing post-operative complications. •08:00: Strategies for managing pain and inflammation with natural supplements. •09:00: How to integrate physical therapy early to speed up recovery. •13:00: Importance of following medical advice and the role of regular follow-ups. •17:00: The benefits of holistic approaches like meditation and yoga in recovery. •18:00: Preparing for surgery: what to do in the days leading up to it. •19:00: Closing advice on maintaining health post-recovery. •20:00: Recap of key points and final thoughts on effective recovery strategies. RESOURCES 1.“What to Eat During Your Recovery After Surgery” - Discusses nutritional strategies for postoperative healing 2.“Pharmacogenetics - Genes affecting cytochrome P450 enzymes” - Details how genetic factors influence drug metabolism 3.“The Importance of Antioxidants in Healing” - Explains the role of antioxidants like NAC and Curcumin in recovery 4.“Glutamine and Wound Healing” - Outlines how glutamine supports nitrogen balance and reduces hospital stays 5.“Vitamin C and Wound Healing” - Discusses the benefits of Vitamin C, especially in combination with other supplements for pressure ulcer patients 6.“Red Light Therapy and Its Benefits in Postoperative Care” - Details how low-level laser therapy aids in reducing scarring and enhancing healing 7.“Soft Tissue Management Post-Surgery” - Highlights the benefits of soft tissue therapy in post-surgical recovery CONNECT WITH NURSE DOZA •JOIN MY SCHOOL for $5: Sign Up Here •YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA •Instagram: https://www.instagram.com/nursedoza/ •Website: http://www.nursedoza.com/ •LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/ •TikTok: https://www.tiktok.com/@nursedoza •Twitter: https://twitter.com/nursedoza
In this episode, Dr. Rena Malik, MD explores the potential benefits and science behind L-Arginine and L-Citrulline for improving erectile function. She discusses how these supplements increase nitric oxide levels in the body, which can enhance blood flow and erectile performance. By examining various studies, Dr. Malik highlights the efficacy of L-Arginine in men with mild to moderate erectile dysfunction and notes the advantages of L-Citrulline's better bioavailability. Listeners will gain valuable insights into the possible use of these supplements for stronger, longer-lasting erections while also being informed about potential side effects and precautions. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 L Arginine 02:48 Precautions and Side Effects 03:44 L Citrulline Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices
Save Our Supplements!; Taking statins in the setting of low-carb diets; Are there any downsides to taking L-arginine for erectile dysfunction?; I've developed aphasia and it's progressive. Am I doomed to this neurological deterioration?
Today I'm joined by Dr Nathan Bryan who was recruited by the Nobel prize winner Dr Ferid Murad to research Nitric oxide, a molecule with an enormous potential to prevent disease. In this episode we discuss what nitric oxide is and why its so significant to the human body. We hear the role it plays in optimal cardiovascular function and how an inefficient cardiovascular system negatively affects other body systems including sexual and cognitive function. We hear about the relationship diet plays in respect of nitric oxide plus we hear the role of the amino acid L Arginine in the formation of Nitric Oxide. Discover why you should not be using mouth wash, antibiotics over a long period of time or antacids. We hear about the surprising first signs of Nitric Oxide deficiency. Plus expect to learn how we can optimise Nitric Oxide production in our bodies through our own diet and behaviours. www.n1o1.com www.drnathansbryan.com https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w Order Happy Habits for Mind and Body Audiobook: https://rb.gy/h5jjjg Order Kindle copy of Happy Habits for Mind and Body : https://rb.gy/jiojcc Order US paperback of Happy Habits for Mind and Body : https://rb.gy/sirste Order UK paperback of Happy Habits for Mind and Body : https://rb.gy/jtfea5 Listen to all previous podcast episodes of the Happy Habit Podcast via these podcast platforms : Apple Podcasts https://podcasts.apple.com/ie/podcast/happy-habit-podcast Amazon https://www.amazon.com/Happy-Habit-Podcast/dp/B08K5887J8 Amazon music : https://music.amazon.com/podcasts/670836c2-ea4c-4a23-a67d-a54dd804ef61/happy-habit-podcast Spotify https://https://open.spotify.com/show/2VKIhQK6mYTzLCO8haUoRd Google Podcasts : https://t.ly/hTU8q ----- Follow the Happy Habit Podcast at: Website: https://happyhabitpodcast.wordpress.com/Facebook: Twitter: https://twitter.com/mathieunorry Instagram: https://www.instagram.com/happyhabitpodcast/ Newsletter:
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Elise: Hi Dr Stephen Cabral, firstly - huge thanks for turning my life around with your protocols since 2018. Forever grateful. My question is, I recently saw an advertisement for a skin supplement called Activated You, and it said consuming collagen internally is basically useless, and that what we really need to consumer are other things in their skin care supplement and in particular: Lysine, L-Arginine, and L-Proline. What are your thoughts on this? Do you include these in any of your products? I take the DNS powder daily. Thanks, Elise Javier: Good Morning Doc! Hope all is well with you , family and business! Question for you…recently I've went from sauna to 55 degree cold dip…and I've been coughing up blood… they found a small infection in my lower left lung…Antibiotics cleared it out…so a day before the follow up appt I dipped again and coughed up even more after a 30 min sauna and 50 degree dip… After several blood cultures and lung function test showed clear they decided to do a bronchoscopy which looked clear but she's waiting on results on fluid biopsy tests… My pulmonary doctor is pretty sure it's hymoptysis but wants to rule everything out… just wanted to see your thoughts on this and if you've e heard of any other cases like mines. I've done it for a year very frequently with no issues…same method…hop from sauna Pati: Hi Dr Cabral, I recently has a transvaginal ultrasound and the findings were that everything was normal. My doctor mentioned things looked good. But on the results also found Cervix: Nabothian cyst. Have you had any experience with client who have had these before and if so are they any suggestions of how to eliminate them? Sorry if this is TMI! Thank you for all you do! Paty: Hello Dr Cabral,I have questions about my son's health.Vegetarian,10 yrs old,he doesn't like (vegetables,fruits,eggs,milk,smoothies) but he loves cheese so he will only eat salads with cheese and dressing and he likes sweets.His hands gets so dry and itchy,Dr said eczema gave me a cream when it flares.Also the skin on his back is having areas of discoloration.He tends to be anxious,ocd,eye tics, nose bleeds constantly and is stuffy,ENT Dr wants to do a procedure for enlarged turbinates and cauterize but it has been done many times. His iron tends to be low.Currently he takes cod liver oil,children multivitamin with iron,folate with B12,calcium gummies with D3 and comfort shen for anxiety. What tests and protocols would you recommend for him, should he do the ENT procedure? Thanks Summer: Hi Dr. Cabral! I do weekly coffee enemas, and sometimes more when I feel it's needed. Although I have seen great benefit in many ways from this schedule, I've had an IHP tell me that they can strip away too many minerals along with the toxins. I listen to several natural health practitioners I trust who do them every single day. I intend to ask them how their mineral levels are personally since every day seems excessive. Some of them will do a mineral rich implant enema of wheat grass, chlorophyll, liquid mineral supplements, potassium, or herbal blends after the coffee, and some don't do anything. I always replenish through the day by drinking electrolytes, fruit/veggie blend, bone broth, or veggie juices. What are your thoughts on any of these mineral rich implants? Thanks! Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/2942 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Amino acids are the building blocks for proteins. In this crash course, we take a deep dive into 7 amino acids and their benefits to health and wellness.1. L-Arginine 2. L-Carnitine3. L-Glutamine4. L-Lysine,5. L-Tryptophan6. L-Tyrosine7. N-Acetyl L-Cysteine (NAC)Within the diet, there are ten essential amino acids that must be obtained through eating. Then, there are conditionally essential amino acids that the body can actually produce, like N-acetyl cysteine (NAC) and L-glutamine. However, under certain conditions, like illness, the body may require more than the body can produce. Therefore supplementation of these may not only be beneficial, but vital.My favorite amino acid supplements:Virid (Lysine) - http://glutenfreesociety.org/ViridL-Glutamine - http://glutenfreesociety.org/L-GlutamineL-Carnitine - https://www.glutenfreesociety.org/shop/health-focus/energy-focus/l-carnitine/Acetyl L-Carnitine - https://www.glutenfreesociety.org/shop/health-focus/energy-focus/acetyl-l-carnitine/Ultra Adrenal Support (Tyrosine) - http://glutenfreesociety.org/UltraAdrenalSupportUltra NAC - http://glutenfreesociety.org/UltraNACUltra Aminos - https://www.glutenfreesociety.org/shop/grouped/ultra-aminos/ #aminoacids#crashcourse
We shift gears to the powerful simplicity of fasting and its profound impact on our mental and physical states. Discover with us the sharpening effects of various fasting methods, from 16/8 to OMAD, as they echo ancient hunting rituals and modern-day health goals. We cast a light on the practicality of post-fast meals, the misunderstood role of electrolytes, and even the unexpected fashion critiques that weave through our festive banter, sharing personal tales and inviting you to join our collective quest towards clarity and health.Wrap up your listening experience with an insider's peek at breaking a fast without breaking your stomach, balancing post-feast nutrition, and the intriguing transition into ketosis. We'll also dish out doses of humor and heart as we recount our own fasting follies and triumphs—like the tale of a 60-hour fast that tested our resolve—while weaving in the benefits of supplements like L-Arginine for overall vitality. And because we're more than just a podcast, we extend the heartfelt invitation to fast alongside us, fostering a community bond as strong as the resolve to skip that next late-night snack.https://amzn.to/48nlhKs (LMNT)https://amzn.to/3NC2wLs (Trace Mineral Drops)Support the showYouTubeInstagram Tik Tok
In this episode of TAC "TIC" Talk, Jaclyn Touzard and Dr. Joe Busch are joined by the formulator of CARDIO MIRACLE, John Hewlett, who shares his life-changing discoveries in the field of Nitric Oxide absorption and its powerful effects on cardiovascular health. In 2007, John Hewlett suffered serious complications after an emergency appendectomy that led to severe heart issues. While hospitalized in critical condition, the doctors recommended heart bypass surgery; he, however, decided to search for natural alternatives. John came across the "miracle molecule" Nitric Oxide, a well-known and powerful neurotransmitter vital for a healthy cardiovascular system. He found a nitric oxide-boosting supplement, allowing him to survive and thrive decades after his brush with death without a single heart surgery. This second chance at life is what inspired him to develop the finest nitric oxide supplement on the planet, coined after Nitric Oxide's moniker: "CARDIO MIRACLE." As the Founder, manufacturer, and distributor of Cardio Miracle, John Hewlett has been on a journey for more than a decade and a half, perfecting his formula with the help of the brightest and most credentialed scientists, nutritionists, and nitric oxide researchers to determine the most effective and value-driven delivery of safe and sustained nitric oxide therapy. He enthusiastically shares the scientific research underscoring nitric oxide's pivotal role in cardiovascular health. It facilitates vasodilation, maintains endothelial integrity, and regulates blood pressure, reducing hypertension risk. Nitric oxide's antioxidant properties safeguard against oxidative stress. It also reduces clot formation by inhibiting platelet aggregation. The studies also show great promise in alleviating angina and coronary artery disease symptoms by enhancing coronary artery blood flow, especially when paired with other breakthrough components in the formula, such as L-arginine. His formulation produces more nitric oxide in the body, produces it faster, and sustains it longer. John considers this his life's calling and mission—to help people take charge of their health and enjoy life to the fullest. To learn more about this unique health product, visit www.cardiomiracle.com or call 1-800-663-0158 for more information. Spotify: open.spotify.com/show/36Pzhe2j91IYqRk0TpnzoI Apple Podcasts: podcasts.apple.com/us/podcast/tac-tic-talk/id1636494989. Google Podcasts: podcasts.apple.com/us/podcast/tac-tic-talk/id1636494989 The American Chiropractor is dedicated to "the Continuing Education and Advancement of the Chiropractic Professional," providing the highest quality articles and resources month after month and year after year to the chiropractic community for the development of each of its readers and of the profession as a whole. Access all of our new and exclusive content here: subscribe.tac-web.com/confirm-now
In this episode, join Dr. Sanjeev Goel in introducing Greg Mckettrick, a compounding pharmacist specializing in sexual dysfunction treatment. Greg delves into the role of nitric oxide in sexual health, its age-related decline, and potential heart issue indicators. Learn about nitric oxide production through L-Arginine and dietary nitrates, with insights on supplement reliability. Discover the importance of oral enzymes, good oral care, and the rapid benefits of nitric oxide supplements like Berkeley Life. Greg advises on intake adjustments, discusses side effects, and spotlights ongoing clinical trials for improved sexual health. Get answers to your questions and explore Greg's expertise with Revelation and Berkeley Life. Be sure to like, share and subscribe!
3 MONTH (FREE) COACHING PROGRAM: CLICK HERE! N101 Nitric Oxide The Truth About Nitric Oxide Being An Anti Aging Miracle Hey everyone, welcome back to my podcast. Today, I want to dive into the world of nitric oxide and explore the benefits, myths, and misconceptions surrounding it. Recently, I came across a certain company, N101, who was talking about how poor the supplements L-Arginine and L-Citrilline actually were for nitric oxide production in the body. I decided to do my own research to find out more, and here's what I discovered. Segment 1: Nitric Oxide 101 Let's start with the basics. Nitric oxide is a molecule that the body produces naturally. It plays a crucial role in blood flow, cardiovascular health, and athletic performance. As we age, nitric oxide levels decrease, which can lead to various health conditions. Segment 2: The Benefits of Nitric Oxide I was surprised to learn about the numerous benefits of nitric oxide. It can improve cardiovascular health, lower blood pressure, reduce inflammation, enhance athletic performance, and increase endurance. Nitric oxide may also have potential benefits for brain health, sexual health, and overall immune function. Segment 3: The Myths and Misconceptions I came across many myths and misconceptions about nitric oxide during my research. One of the most common myths is that supplements like L-Arginine and L-Citrilline are effective in increasing nitric oxide levels. While the body can convert L-Citrilline to L-Arginine, which can then be used to produce nitric oxide, some studies have shown that these supplements may not be as effective as previously believed. Segment 4: N101's Claims About L-Arginine and L-Citrilline I was intrigued by N101's claims about L-Arginine and L-Citrilline, and I decided to try the product myself and have been surprised with the results. If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at projectb36@gmail.com or visit my website at www.Over40FitnessHacks.com. Additionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV
In this episode of The Performance Medicine Show, Dr. Rogers answers YOUR health and wellness questions! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine
This month on Episode 43 of Discover CircRes, guest host Nicole Purcell highlights two original research articles featured in the December 2 issue of Circulation Research. This episode also features an interview with Drs Aaron Phillips and Kevin O'Gallagher about their study, The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans. Article highlights: Akerberg, et al. RBPMS2 Regulates RNA Splicing in Cardiomyocytes Lv, et al. Cardiac Protection by MG53-S255A Mutant Nicole Purcell: Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I am your host, Dr Nicole Purcell, from the Huntington Medical Research Institutes in Pasadena, California, and today I will be highlighting two articles from our December 2 issue of Circulation Research. I'll also have a chat with Drs Aaron Phillips and Kevin O'Gallagher about their study, The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans. Nicole Purcell: But before I get to the interview, here are a few article highlights. The first article we're going to highlight is RBPMS2 Is a Myocardial Enriched Splicing Regulator Required for Cardiac Function. This comes from Boston Children's Hospital with first author Dr Alexander Akerberg, and corresponding author Dr Jeffrey Burns. RNA splicing, along with transcription control and post-translational modifications, is a mechanism for fine tuning the expression of a gene for a particular purpose in a particular tissue. Factors that control splicing are thus often enriched in certain cell types. The factor, RBPMS2, for example, is enriched in the myocytes of amphibians, fish, birds and mammals. This conserve tissue specificity suggesting essential role of RBPMS2 in heart function. Akerberg and colleagues now confirm this is indeed the case. They generated zebra fish embryos and human cardiomyocytes lacking RBPMS2, and found the fish suffered early cardiac dysfunction by 48 hours post fertilization. The animal's hearts had reduced ejection fractions, compared with the hearts of controlled fish. At the cellular level, the RBPMS2 lacking fish cardiomyocytes displayed malformed sarcomere fibers and disrupted calcium handling, both of which were also seen in the RBPMS2 deficient human cardiomyocytes. Furthermore, RNA sequencing experiments revealed a conserve set of 29 genes in the RBPMS2-lacking fish and human cells that were incorrectly spliced. In revealing the essential cardiac role of RBPMS2 and its RNA targets, the work provides new molecular details for understanding vertebrate heart function and disease, say the team. Nicole Purcell: Our second article being highlighted is Blocking MG53 Serine 255 Phosphorylation Protects Diabetic Heart from Ischemic Injury. This comes from Peking University with first authors, Fengxiang L, Yingfan Wang and Dan Shan, as well as corresponding author Dr Rui-Ping Xiao. Midsegment 53, or MG53, is a recently discovered muscle-specific protein that is an essential component of the cell membrane repair machinery with cardioprotective effects. MG53 thus has therapeutic potential, but for patients whose heart disease is linked to type 2 diabetes, there's a problem. MG53 also tags certain cellular proteins for destruction, including the insulin receptor and the insulin signaling factor, IRS1. Loss of these factors could worsen insulin resistance. lev and colleagues therefore investigate whether MG53 could be tweaked to provide protection without the diabetes downside. Nicole Purcell: They discovered the phosphorylation of MG53 at serine 255 is required for its role in protein destruction, and that a mutant version of MG53, incapable of this phosphorylation, MG53 serine to 255 alanine mutant, could still promote cardiomyocyte survival, and protect the cells from membrane damaging insults. Importantly, when a diabetic mouse model was injected with MG53 serine 255 to alanine mutant, the protein better protected the animals against myocardial infarction than injection with the wild type MG53, recipients of which had poor insulin sensitivity. Based on these findings, the authors suggest MG53 serine 255 alanine mutant could be developed into a heart protective drug, for use in diabetic and non-diabetic patients alike. Nicole Purcell: Today, Dr Aaron Phillips and Dr Kevin O'Gallagher from University of Calgary are with me to discuss their study, the Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans in our December 2 issue of Circulation Research. Thank you for joining me today. Kevin O'Gallagher: Hello, my name's Dr Kevin O'Gallagher. I'm a British Heart Foundation clinician scientist and interventional cardiologist at Kings College London and Kings College Hospital NHS Foundation Trust. Aaron Phillips: Hello, my name's Dr Aaron Phillips. I'm an associate professor in physiology, pharmacology, cardiac sciences, biomedical engineering and clinical neurosciences at the University of Calgary in the Hotchkiss Brain Institute and Libin Cardiovascular Institute. I am also the director of the Restore Network, which is a large platform at the University of Calgary spanning all these groups, developing new tools and techniques for translational research into neurological conditions. Nicole Purcell: There are a lot of authors involved in this study. While all could not join us, I appreciate you taking the time to discuss your findings today. Your paper deals with looking at neurovascular control in humans. Two primary regulatory pathways are neurovascular coupling, or NVC, and dynamic cerebral autoregulation. Dr Phillips, can you explain what NVC to our audience, and what does dysregulation lead to? Aaron Phillips: Yeah, thanks Nicole and I'm happy to be here. Thank you for the invitation. NVC, or neurovascular coupling, we've been studying it for about 15 years. At its fundamental level, it's kind of this elegant interplay between neurons, which unfortunately have very limited capacity for substrate storage. The brain has very limited substrate storage capacity, and so neurons need to very rapidly match their metabolic activity to the blood flow that's being delivered to them, and that needs to happen locally, for areas of the brain that have greater metabolic needs as opposed to other areas. What happens, in terms of dysregulation or conditions that are associated with dysregulation, it's an interesting story because we still really need to understand the mechanisms fully, in order to suss out what clinical conditions should have dysfunction of this unit. We know that certain conditions, such as vascular cognitive impairment, even spinal cord injury, we've done some work in stroke patients, it seems to be dysfunctional in all of these conditions, but understanding exactly why it's dysfunctional, we're still establishing that. Nicole Purcell: Great. You were talking about how it's the connection or interplay between blood flow, so we're talking about altered blood pressure seems to play a key role in neurovascular coupling. So, for those listeners not familiar with this field, can you explain how nitric oxide synthase and its isoforms, how this relates to NVC? Aaron Phillips: Well, nitric oxide synthase is an enzyme that produces nitric oxide that's expressed primarily in neurons. Nitric oxide is a powerful vasodilator. It actually works on quite a rapid time course. So, we surmised, we suspected, and there were some preclinical work before our human study, that neuronal sources of nitric oxide, being that nitric oxide is a potent vasodilator, we thought that would be likely to be mediating a large part of the neurovascular coupling response. Nicole Purcell: Great. So, Dr O'Gallagher, based on that, what was your main objective or hypothesis of this study, and how is your study novel from those that have already just suggested, looked at NOS regulation for cerebral blood flow? Kevin O'Gallagher: Thanks very much for the invite to talk. I mean, we hypothesized that nNOS would have a role in regulating neurovascular coupling. I think the novelty of our study is that although people have been interested in NOS and its regulation of cerebral vascular and cardiovascular blood flow, it's only relatively recently that there has become an agent available that will specifically inhibit nNOS, and therefore give us an idea of what it is doing, rather than previous inhibitors which just inhibit all of the three NOS isoforms. It was really that the development of the agent was what allowed us to do this study. I think it was really through that, that makes this an interesting finding that nNOS does play a role in neurovascular coupling, and really pushes the field forward ever so slightly. Nicole Purcell: Great. So, as you pointed out, this is a specific nNOS inhibitor, which is known as SMTC. It's a synthetic L-Arginine analog, right? That's really what sets your study apart. Can you tell us a little bit the audience, whether that be you, Dr Phillips or Dr O'Gallagher, about what your study was and what did you find, and how did an ambition of using this SMTC to inhibit nNOS affect systemic hemodynamic changes and NVC? Aaron Phillips: Yeah, I think both of us can probably speak to this interchangeably and add in different elements of the experiment. This is kind of a summary of the study, I guess. In advance of this, adding on what Kevin had just said in terms of the novelty of the study and the importance, we had done a lot of work previous to this paper where we were one of the groups that helped establish neurovascular coupling as a measure that could be tested in humans. This involved kind of understanding metabolism of the eye, how that's coupled to the visual cortex, and how to measure blood flow on a high temporal resolution in the visual cortex in response to visual input. That's why we used very well standardized perturbations involving tracking an eye, tracking a dot on a screen at a known one rate and a known one amplitude of movement, while also measuring the hyperemic response in the posterior brain. Then we kind of went on and developed some new measures, developed some software that we're now proud is used in a few different labs around the world, that kind of automatically takes that input of repetitive eyes opening and closing and that hyperemic response, and it breaks it down into a single wave form. A single hyperemic response is superimposed of 10, 15, 20 cycles of those eyes open and eyes closed, and then when we superimpose all the wave forms together, we can generate different metrics from that hyperemic response that correspond to different elements. One of the ways where software can, I guess dice out the hyperemic response, is by timing. We can look at very specific unique time windows over that 30 seconds of eyes open, and we can also look at the slope of the response, as well as we recently did some dimensionality reduction techniques and looked at specific computed measures of that hyperemic response. We published that a few years ago. Those were some of the tools that enabled this study, along with a fantastically unique drug that really could isolate that neuron expression of NOS and the capacity of nNOS to mediate neurovascular coupling. Kevin O'Gallagher: Obviously, we're going to use a systemic infusion of SMTC, the study drug, and we've used that before and shown it to be safe. But because a systemic infusion of SMTC through peripheral and systemic nNOS inhibition does cause an increase in systemic vascular resistance, and therefore an increase in mean arterial pressure of around about 7 mm of mercury, in addition to a cline placebo control condition, we also felt the need to have a pressure control condition. For that, we used phenylephrine to match the rise in mean arterial pressure that we anticipated we'd see with SMTC. We ended up with 12 healthy volunteers who attended on three separate visits, and so we had a party randomized double blinded intervention study where we measured the neurovascular coupling metrics, both before and after an infusion of one of the three conditions on each particular visit. Aaron Phillips: I just wanted to add into that, we had found previously that mean arterial pressure does have an effect on the hyperemic response. This was actually classically found by 1960s by Harper and Glass in a dog study, but we've repeated that in humans and kind of found that the ability of the brain to kind of... It's reserve for further vasodilation is dependent on pressure. As you drop it, neurovascular coupling will go away, and as you increase it, neurovascular coupling will increase partially, so it's important to standardize the mean arterial pressure levels. I always liken it to your water pressure in your house. You can't turn on a faucet with a given pressure unless you have that in the system upstream. That was a really important aspect of the study. Nicole Purcell: That was quite unique for your study, too. Not a lot of people have control for pressure. Aaron Phillips: Correct. Kevin O'Gallagher: I think it reflects the challenges of these healthy volunteer studies where you're trying to look at one particular part of the cardiovascular system, because as a cardiologist, if we were doing a study like this, looking at cardiovascular regulation, we would put a catheter into the coronary arteries in patients who had come for angiograms, and we'd give a local infusion of SMTC, as we've done in studies before. But with healthy volunteers, and ethically it really demanded a systemic infusion, so it was a really nice workaround to have that pressure control condition. Nicole Purcell: So, can you tell us a little bit about what your findings were? Kevin O'Gallagher: I think testament to the study design and the rigorous methodology that we employed, we did find with the resting steady state hemodynamics that SMTC condition performed as we would expect, and as we've seen in prior studies where we've given a systemic dose in that compared to both placebo and pressure control conditions, SMTC decreased cardiac output, and it decreased stroke volume, and also increased systemic vascular resistance, so very much as expected the resting hemodynamic conditions. Aaron Phillips: Yeah, thanks. Just adding onto that, moving on into some of the cerebral vascular measures. So again, we were measuring posterior cerebral artery velocity, blood velocity and specific responsiveness that it has to a visual stimuli. Between conditions, we didn't see a change in resting posterior cerebral artery velocity, so that was consistent between the conditions. Where we saw most of our change actually was in this very early period, the first five seconds of what we're going to call the hyperemic response, or the first five seconds of the neurovascular coupling response. That's where we saw our primary effect. We didn't see an effect in almost any of the neurovascular coupling measures that we generated in the actual sustained period after that initial rise, so that's where we saw our key inhibition with nNOS inhibition. What permitted that was the phenylephrine control group, again, allowing us to really look at apples and apples, not apples and oranges. Nicole Purcell: Great. So that early transient change that you saw, that as you said, hyperemic response, what therapeutic implications does this have for the field? Kevin O'Gallagher: Well, certainly there are conditions in which nNOS dysfunction, nNOS may be implicated, we mentioned a couple in the paper, some neurodegenerative diseases. But also, I think the field is now open for any vascular mediated headache syndrome, such as migraine, to investigate the potential role of nNOS from that angle. Then we haven't touched on already, but as well as dysfunctional, so decreased nNOS activity, there's also some conditions in which there's dysregulation or abnormally increased nNOS function. Again, we've highlighted this kind of study methodology is a tool that could be used to investigate those types of conditions. Aaron Phillips: These are all terrific points, and I think there's a lot of conditions where neurovascular coupling is impaired, and it's worth exploring them and understanding the specific role where nNOS might be a part of it. I also think there's a lot of interesting basic science surrounding this, in terms of the mechanisms. What was really interesting in this study, which is still kind of wracking my brain, is why didn't more of the neurovascular coupling response go away? This is a highly selective inhibitor for what was potentially thought by some groups to be a large mediator, this response. It was a relatively small inhibitory effect, and isolated to a small part of the neurovascular coupling response, just that early phase. So, still lots of work to do to kind of dice out the other pathways. They're probably highly redundant. This is such a critical mechanism in the central nervous system. Getting at it and humans is going to be tricky, but we're excited about the future and exploring some of those other avenues on the mechanistic cascade. Nicole Purcell: Based on the fact that you just had 12 healthy individuals, what do you see as some of the limitations of your study going forward, thinking about what you did? Kevin O'Gallagher: I think you've just hit on a key limitation. It was a small number of volunteers. They were all healthy, so we can't extrapolate these findings to conditions such as hypertension, where we know from other studies that cardiovascular responses, nNOS responses are impaired Also, this was a noninvasive study. We looked at the blood flow through Doppler, but we don't really know the effect of SMTC on cerebral artery diameter or other markers like that, so I think those are important limitations to mention. Nicole Purcell: I know I didn't ask this, and I know it was mentioned in the paper, but for our audience, and it was a small sample size, but did you see any sex differences between your male and female cohort? Kevin O'Gallagher: No. We did analyze for that and there were no sex differences. But again, it's an important limitation in that we didn't control for things like phase of the menstrual cycle. And again, with those limitations, all the results should be interpreted with those in mind. Nicole Purcell: Were there any challenges to the study that you found? Kevin O'Gallagher: I work in London in the UK, where we performed this study related protocols, and Professor Phillips from University of Calgary, his team flew over to perform the studies. I think there was a real organizational challenge because we had a relatively small time window in which to get all of the volunteers and their three study visits done. But I think it's testament to just how well Professor Phillips runs his team, and how fantastic a team they are in working together that all of those challenges were minimized and everything. It ran fairly smoothly, and certainly, the data was connected back in early 2020. I think we all retrospectively breathed a sigh of relief when the Covid pandemic started and we realized that had we had to reschedule another set of visits, we would've then knocked the study back a couple of years. So yeah, there were organizational challenges, but it was an absolute pleasure to work with Professor Phillips's and his team in this. Aaron Phillips: To add to that, I mean, it's not really related to necessarily the challenges, but I was going to list kind of the exact same thing. In the background. Kevin, and Professor Shaw, and Dr Gallagher were a tour de force on organizing quite a complicated study that involves some invasive protocols and unique experimental drug infusion. Getting all of that ethically approved, and organized, and structured, that was probably one of the biggest challenges of pulling this study off. Nicole Purcell: Great. It was a very nice study. So lastly, what future studies are needed or have come out of this work that you'd like to tell us about? Aaron Phillips: Mechanistically, I would still like to explore why nNOS inhibition doesn't seem to affect the sustained elevation in blood flow. This maybe means going back to some of the astrocyte mediated mechanisms, and understanding knocking out, knocking in, exploring some of those. I'd also like to continue to study the neurovascular cupping response itself in clinical conditions. This may be a tool for helping to characterize the severity of a given neurovascular condition over time, and kind of validating this outcome measure as potentially a clinical tool and further expanding its research application. Kevin O'Gallagher: I would just add to that, that I tend to come to all of these things from a cardiologist light, and there are some conditions in cardiology where the microvascular is involved, and so the interest is then to see whether there's a linkage between the dysfunctional coronary microvascular responses with then cerebral microvascular responses. So again, I think there's plenty of future work to be done in that sphere. Nicole Purcell: Well, I want to thank you so much for joining me today, Dr Kevin O'Gallagher and Dr Aaron Phillips, for discussing your exciting findings with me today, and I look forward to seeing your future work. Thank you. Aaron Phillips: Thank you so much. Kevin O'Gallagher: Thank you so much. Nicole Purcell: That's it for highlights from the December 2 issue of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Drs Aaron Phillips and Kevin O'Gallagher. This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy texts for highlighted articles provided by Ruth Williams. I am your host, Dr Nicole Purcell, filling in for Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most up-to-date and exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more, visit ahajournals.org.
l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms --- Support this podcast: https://anchor.fm/ralph-turchiano/support
Long Covid Fatigue L-Arginine Liposomal C l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms --- Support this podcast: https://anchor.fm/ralph-turchiano/support
The Case: Cindy is experiencing hormone imbalances, fatigue and a low sex-drive She has consulted with a gynecologist but was dismissed and told it was common for her age She wasn't willing to accept that she just had to get used to having a low libido so she came to see me Investigation While it is true that hormonal shifts in peri-menopause and menopause can cause a decrease in a woman's sex drive, there is more to take into consideration. I knew that we had to look a few different avenues to get to the bottom of her health mystery, and find a solution that would reinvigorate her sex life. Shifting Views on Intimacy Susan Bratton is an intimacy expert and an advocate for shifting how we talk about and approach desire, intimacy and passion. She's a best-selling author and has published 34 books and programs on the subject. She advocates for better experiences not only for those like Cindy, who are experiencing low libido, but for all women. She does this through her work teaching passionate lovemaking techniques, reframes what communication sounds like in the bedroom, and covers the physical limitations that a woman may be experiencing that can impact enjoyment or pleasure. Getting the Root Cause of Intimacy Issues Susan says that couples seldom investigate what is causing issues in the bedroom as it relates to the three areas she focuses on (technique, communications, and physical pleasure). Most will find the root cause in our cultural depictions of intimacy derived from our patriarchal society. When it comes to getting the root of issues with libido or physical arousal for women, it can have to do with the first two categories but sometimes, the issue stems from menopause or peri-menopause, an immune issue, or a hormone issue like hypothyroidism. Many are unaware of the connection between hormone issues and low libido because they are less likely to list it as a symptom to their doctor. Even if they do, the doctor is unlikely to treat it as a concern. Switching the Patriarchal Paradigm of Intimacy One of the issues Susan discusses at length in this episode is the challenge women face becoming aroused (and overcoming low libido) in the patriarchal paradigm of what intimacy looks like. She says that the patriarchy has created the male-focused approach to intimacy which centers around intercourse. And, she says, many women go along with it because it's all they know. To reframe this paradigm, women need to think of their partner as someone who can help with the healing through the creation of a good relationship including making you feel vital again, focusing on your satisfaction, and connection through orgasm. The Fatigue and Romance Conundrum When you are dealing with things like fatigue, insomnia, gut issues, or chronic pain - romance may be the last thing on your mind. Mustering up the energy for a kiss might seem like too much effort. However, Susan says orgasms can be very healing. They reboot your nervous system. They send out feel good neurotransmitters and hormones. They are a vascular event so they are like a little workout for your blood system. They improve sleep. And they create a deeper connection or bond with yourself and your partner. So, even if you don't feel like it, it might be good medicine. However, you may want to take it slow and be patient as you build up desire - especially if you are dealing with a physical issue (like hypothyroidism or hashimoto's) that has depleted desire or moved intimacy way down on the needs list. Solutions for Vaginal Dryness Vaginal dryness can be one of the reasons women avoid intimacy. This can be caused by a drop in estrogen (likely after the age of 50 because this is what happens during menopause). Or, it could be due to diet. Natural lubrication of the vaginal tissue is created through nitric oxide production. This is supported by a diet rich in leafy greens and vegetables - specifically celery, beets, dill, cabbage, arugula, and romaine. It can be impeded by the use of antibacterial mouthwash, acid blockers or proton pump inhibitors. There are supplements to boost nitric oxide production but the most commonly recommended is L-Arginine. Here are Susan's top tips for vaginal dryness: Diet rich in leafy greens and vegetables (which contain nitric oxide) Supplement nitric oxide production Stay well hydrated (drink water) Engage in foreplay to ensure there is enough time for proper arousal Use organic nut oils (refined organic avocado oil, sweet almond oil) Not engaging until you are ready Don't get discourage - you are not broken Beyond that, Susan also suggests supplements that might help you get in the mood. These include: Cacao (chocolate without the sugar) Maca Tribulus Terrestris Tongkat Ali Fenugreek Conclusion In this episode, Susan really exposes that libido is something that needs to be addressed from all angles. In Cindy's case, we started by doing a DUTCH test and looking at her hormones. She was pretty low but wasn't interested in doing bio identical hormones yet. Instead, we supported her DHEA with DHEA drops. To bring her estrogen back into balance, we used Fem Guard by Designs for Health. Additionally, we also worked on blood flow with amino acids and supplements that help to naturally increase nitric oxide from the biochemical side. With her biochemistry supported, we also looked at what she could do to further support her libido. We talked about making sure she was moving her body regularly, doing breathwork and spending time on her own and with her partner. I connected Cindy with a sex therapist who was able to guide her and her partner on the emotional part of their journey. The biochemical support, a few shifts in her lifestyle, and the therapy all resulted in a significant increase in Cindy's sex drive after just 3 months. Needless to say, everyone was happy. Eliminating Health Mysteries For Cindy we were able to find that missing piece of the puzzle and help her regain her healthy sex life. Could this be the missing clue for you or someone in your life? Links: Resources mentioned Thanks to my guest Susan Bratton. You can connect with her and check out all of her resources on her website: https://betterlover.com Suggested Products DHEA drops Fem Guard Amino Acid Synergy Maca L-Arginine Related Podcast Episodes: The Case of the Super Low Libido w/ Lauren Handel Zander 096 Demystifying Hormones for Perimenopause and Menopause Demystifying Hormones for Perimenopause and Menopause (Part 2) Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode - Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show! Find out more at http://healthmysteriessolved.com PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses.
Video: Interview with Dr. Rupert Sheldrake (41:21) Stomach cancer cells halted with whole tomato extracts Sbarro Institute for Molecular Medicine at Temple University October 10, 2022 The Mediterranean diet has become regarded as highly beneficial to overall health, maintaining ideal weight and a reduced risk of cancer plus many other chronic disease conditions. One of the staples of this diet is tomatoes, especially the low-acid varieties that are grown in Italy and its impact on cancer risk is quite interesting. Recent research by the Sbarro Institute for Molecular Medicine at Temple University in Philadelphia, Pa. has confirmed that two tomato cultivars grown in Southern Italy inhibit both malignant features and cellular growth in stomach cancer cells. For the study, whole tomato lipophilic extracts were analyzed for their ability to fight and diminish neoplastic features of stomach cancer cells. Both the Corbarino and San Marzano tomato varieties were found to inhibit the cloning behavior of malignant cancer cells as well as impede their growth. When tomato extracts were used on stomach cancer cells, key processes related to cell development, migration and proliferation were inhibited. The tomato extracts ultimately induced apoptosis, or cancer cell death in cancer cells. The study results were published in the Journal of Cellular Physiology. Significantly, the tomato extracts contributed to the movement of cancer cells away from the primary tumor, which resulted in their death. These anticancer effects weren't related to just one particular compound such as lycopene. Instead, the whole tomato seemed to contribute to its anticancer effects. Previous studies had suggested the carotenoid compound lycopene, which creates the orange-red color of tomatoes, is what fights cancer cells. While lycopene may still be a major factor, the entire tomato seemed to have a highly potent effect against cancer. Amino Acid Arginine Found As Effective As Drugs For Glucose Metabolism And DiabetesUniversity of Copenhagen & University of Cincinnati, October 9, 2022 If you suffer from type 2 diabetes, you may want to consider snacking on nuts to treat the condition. Supplementation with the amino acid arginine, commonly found in almonds and hazelnuts, could help to improve glucose metabolism by as much as 40%, according to new research in mice. The study shows that supplementation with the amino acid significantly improves glucose metabolism in both insulin-sensitive and insulin-resistant metabolisms. In new experiments, researchers from the University of Copenhagen working in collaboration with a research group at the University of Cincinnati, have demonstrated that the amino acid arginine, found in salmon, eggs, and nuts, improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. ”In fact, the amino acid is just as effective as several well-established drugs for type 2 diabetics,” says postdoc Christoffer Clemmensen. As improbable as it may seem, the most important molecule in regulating the function of our arteries is nitric oxide (NO), a gas better known to us as an air pollutant. As synthesized in our arteries in tiny quantities, however, NO acts as a powerful mediator of vasodilation, the mechanism by which arteries dilate, when necessary, to lower our blood pressure and increase the flow of blood to tissues that need it. The principal source of our NO is arginine. This occurs via enzyme-catalyzed reactions that occur in endothelial cells, the thin layer of smooth, tightly “tiled” cells that line the inner walls of our arteries. What researchers have found is that L-arginine potentiation of glucose-induced insulin secretion occurs independently of NO. The researchers found that arginine improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. “We can also see that arginine increases the body's production of glucagon-like peptide-1 (GLP-1), an intestinal hormone which plays an important role in regulating appetite and glucose metabolism, and which is therefore used in numerous drugs for treating type 2 diabetes,” said Clemmensen. Supplemental dosages of 6 to 8 grams L-Arginine per day are considered safe. Although available in food, for some applications such as stimulating secretion of growth hormone from the pituitary, it is not released quickly enough as the food is digested. The supplemental doses taken on an empty stomach will arrive at the blood-brain barrier without competition. Then growth hormone secretion will be stimulated which in turn can affect glucose metabolism Increasing green space could narrow lifespan gap between poorest and richest areas University of Glasgow (Scotland), October 19, 2022 Increasing the amount of natural (green and blue) space and private gardens has the potential to narrow the lifespan gap between those living in the most and least deprived areas, suggests research published online in the Journal of Epidemiology of Community Health. Each 10% increase in natural space is linked to a 7% fall in the incidence of early death among the under 65s, the findings indicate. It's not clear if access to natural space might also be associated with differences in lifespan and protection against an earlier than expected death, so the researchers used the measure of “years of life lost,” or YLL for short, to try and find out. Natural space was defined as: woodland; scattered trees; scrub; marsh; heath; open water (inland or tidal); semi natural grassland; general natural areas, such as grass on sports pitches, roadside verges, and farmland; agriculture; hard bare ground, such as rocks, boulders, and cliffs; and soft bare ground, such as sand, soil, and foreshore. Areas with the highest income deprivation had the lowest average percentage cover of natural space and gardens (58.5%, 49–65%). People living in these areas had the highest levels of ill health. The study found that every 10% increase in natural space cover was associated with a 7% fall in the incidence of premature death. Food for thought: Study finds link between depression and unhealthy diets Macquarie University, October 18, 2022 A Macquarie University study of 169 adults aged 17 to 35 found those eating a Western-style diet were more likely to have lower levels of kynurenic acid (KA)—a small molecule important to a number of bodily functions—and report higher levels of depression than those eating diets rich in fresh fruit and vegetables. Neuroscientist Dr. Edwin Lim and neuropsychologist Dr. Heather Francis published a paper on the findings of the study in the journal Frontiers in Nutrition. “Western-style diets high in fat, sugar and processed foods were already known to increase the risk of depression, but this is the first time a biological link involving the kynurenine pathway has been established,” Lim says. “People from the group eating an unhealthy diet had lower levels of KA and more severe symptoms of depression. This indicates that KA may help to protect us against depression.” The human body has a number of ways of producing important molecules and metabolites necessary to keep it functioning. One of these important molecules is tryptophan—an essential amino acid that the body can't make itself, that is found in foods like dairy products, poultry, bananas, oats, nuts and seeds. When tryptophan is broken down, it can produce either serotonin and melatonin—important for our mood and sleep—or it can be processed by the kynurenine pathway, which creates KA and other important metabolites linked to neurodegenerative diseases such as Alzheimer's disease. Lim says this is the first time anyone has been able to show that Western-style diet has an effect on the way that tryptophan is metabolized in otherwise healthy young people. “There is, however, a clear relationship between an increased risk of depression and eating an unhealthy diet that is high in fat, sugar and processed foods, giving us all the incentive to eat more fresh vegetables and fruit,” she says. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2022 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Patients who ate fish, vegetables and whole grains reported a greater reduction in symptoms than those on proton pump inhibitors (PPIs), the study found Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe. In the study, published in the journal JAMA Otolaryngology – experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.' Shorter sleep in later life linked to higher risk of multiple diseases University College London, October 19, 2022 Getting less than five hours of sleep in mid-to-late life could be linked to an increased risk of developing at least two chronic diseases, finds a new study led by UCL researchers. The research, published in PLOS Medicine, analyzed the impact of sleep duration on the health of more than 7,000 men and women at the ages of 50, 60 and 70, from the Whitehall II cohort study. Researchers examined the relationship between how long each participant slept for, mortality and whether they had been diagnosed with two or more chronic diseases(multimorbidity)—such as heart disease, cancer or diabetes—over the course of 25 years. People who reported getting five hours of sleep or less at age 50 were 20% more likely to have been diagnosed with a chronic disease and 40% more likely to be diagnosed with two or more chronic diseases over 25 years, compared to people who slept for up to seven hours. Additionally, sleeping for five hours or less at the age of 50, 60, and 70 was linked to a 30% to 40% increased risk of multimorbidity when compared with those who slept for up to seven hours. Researchers also found that sleep duration of five hours or less at age 50 was associated with 25% increased risk of mortality over the 25 years of follow-up—which can mainly be explained by the fact that short sleep duration increases the risk of chronic disease(s) that in turn increase the risk of death. “Our findings show that short sleep duration is also associated with multimorbidity. As part of the study, researchers also assessed whether sleeping for a long duration, of nine hours or more, affected health outcomes. There was no clear association between long sleep durations at age 50 and multimorbidity in healthy people. Study finds Mediterranean diet more effective cure for acid reflux than meds Feinstein Institute for Medical Research & New York Medical College, October 8, 2017 Sticking to a Mediterranean diet is just as effective at controlling reflux as medicines prescribed to millions of people each year, research suggests. Patients who ate primarily fish, vegetables and whole grains – and drank alkaline-heavy water – reported a greater reduction in their symptoms than those on proton pump inhibitors (PPIs), the small study found. Gastric, or oesophageal, reflux describes the traveling of stomach contents back up into the esophagus — a reversal of the normal flow. This is due to a poorly functioning lower esophageal sphincter, a ring of muscle at the top of the stomach that normally shuts to stop the contents of the stomach leaking out and up the foodpipe. In the study, published in the journal JAMA Otolaryngology, experts compared 85 patients treated with PPIs with 99 who followed a 90 percent plant-based, Mediterranean-style diet, who also drank alkaline water. The diet consisted mostly of fruits, vegetables, grains and nuts and barely any dairy or meat including beef, chicken, fish, eggs and pork. People were also told to avoid known triggers of reflux, including coffee, tea, chocolate, fizzy drinks, greasy and fried food, spicy food, fatty food and alcohol. Patients on the plant-based diet also lost weight and needed fewer medicines for other conditions, including high blood pressure and high cholesterol. ‘The results we found show we are heading in the right direction to treating reflux without medication.'
People with Raynaud's Phenomenon can suffer year round with freezing cold and discolored fingers and toes (or other small body parts). In this episode, we talk about what causes Raynaud's, what to watch out for, how to talk to your doctor about your symptoms, and what to do about it! I review the research and what they've been studying now, including some of the lesser known therapies, such as beetroot juice, L-Arginine, and N-acetylcysteine! Shownotes HERE! -------------------------------------------------------------- Our Brain Health Integrative Guide is gone, to make room for a FREE Integrative Wellness Course Module on "How To Aromatherapy for Women's Wellness". All for Free. My presentation and handout on how to become your own aromatherapist for some of the most common conditions that we have to deal with as women! The science behind aromatherapy, precautions, and how to make your own topical, diffusion, sprays, bath salt blends! Worth $100! All for FREE. For a very limited time, so get it today at www.healthispowher.com. Link Below: You can sign up here! ---------------------------------------------------------------- We hope you enjoy the episode and if you do, please SUBSCRIBE, RATE, and REVIEW So you can help us increase our reach to help more women awaken their best selves, have more energy, and live the life they dreamed of while healing and recovering from any pain and health issues! ---------------------------------------------------------------- Be on the lookout for the foundational coaching masterclasses this coming new year! And for those of you ready to heal from a chronic condition, we will have your advanced master coaching program coming soon for Menopause, PCOS, Endometriosis, Pelvic Pain, Hormone Regulation, Autoimmune Disease, Chronic Fatigue, Fibromyalgia, and More! We will be launching one of these come 2022, so be on the lookout or email us at hello@healthispowher.com to get on the list! ---------------------------------------------------------------- DISCLAIMER Anna Esparham, M.D.is a medical doctor, but she is not your doctor, and she is not offering medical advice on this podcast. If you are in need of professional advice or medical care, you must seek out the services of your own doctor or health care professional. The opinions of podcast guests are not necessarily those of Dr. Esparham, MD and Health Is PowHer, LLC and do not represent her or the company. This podcast provides information only, and does not provide any financial, legal, medical or psychological services or advice. None of the content on this podcast prevents, cures or treats any mental or medical condition. You are responsible for your own physical, mental and emotional well-being, decisions, choices, actions and results. Health Is PowHer, LLC disclaims any liability for your reliance on any opinions or advice contained in this podcast.
Dr. Gráinne Gorman discusses the use of L-arginine in the treatment of mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS). Show references: https://n.neurology.org/content/early/2022/04/14/WNL.0000000000200299
Dr. Justin Abbatemarco talks with Prof. Gráinne Gorman about the use of L-arginine in the treatment of mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS). Read the full article in Neurology.
In this industry-focused episode, Naturals in the News examines a new form of Vitamin B1, an in depth look at the research on Krill oil for cardiovascular health and returned to the conversation about the ruling of NAC through the FDA. Our Naturals in the Know is a delightful interview with Doug Wallace, owner of a health food store in Santa Cruz California who downsized from working for Whole Foods and has a lot of insight into the natural products industry. Our Favorite Things covers Saliva miltiorrhiza also known as Dan Shen or Red Sage root for supporting heart heath and L-Arginine and L- Citrulline two wonderful amino acids for overall circulatory health. Check it out! Show Links Check out the Supplement Super Sleuth & Herbal Storyteller on Facebook Learn more about our work at watersedgewellness.com Guest Links Check out The Food Bin & Herb Room!
In this industry-focused episode, Naturals in the News examines a new form of Vitamin B1, an in depth look at the research on Krill oil for cardiovascular health and returned to the conversation about the ruling of NAC through the FDA. Our Naturals in the Know is a delightful interview with Doug Wallace, owner of a health food store in Santa Cruz California who downsized from working for Whole Foods and has a lot of insight into the natural products industry. Our Favorite Things covers Saliva miltiorrhiza also known as Dan Shen or Red Sage root for supporting heart heath and L-Arginine and L- Citrulline two wonderful amino acids for overall circulatory health. Check it out! Show Links Check out the Supplement Super Sleuth & Herbal Storyteller on Facebook Learn more about our work at watersedgewellness.com Guest Links Check out The Food Bin & Herb Room!
This is for educational purposes only
In this week's episode of the #mindwithmusclepoidcast questions of the week are, L Arginine effective or not? Skinny fat pehle Bulk Karein ya Cut? Is Black Mamba Fat Burner Safe? Which phase of TWN is best for fat loss? Tips for lean bulking. All this and much more in this week's episode of the Mind With Muscle Podcast Enjoy! Important Links: Mind With Muscle Youtube Channel https://www.youtube.com/mindwithmuscle Mind With Muscle Instagram Page https://www.instagram.com/mindwithmuscle_ --- Send in a voice message: https://anchor.fm/mindwithmuscle/message
Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News topic du jour: https://mises.org/wire/how-fiat-money-made-beef-more-expensive L-Arginine: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00405-3/fulltext https://chrismasterjohnphd.com/blog/2021/10/01/the-one-amino-acid-that-cured-covid 1. Calculating How Much Protein For My Bodyweight [19:52] Gloria says: On your last show you talked about having 1 gram of protein for every pound of body weight. Other people say 1 gram for every kg of body weight. Which is it in your opinion? Thanks so much! Keep up the good work. I look forward to your show every week. 2. High Cholesterol and eating more protein [20:56] Kimberly says: Hi Love your show. I have been listening since the beginning. Please never stop recording. In the last couple years (since covid hit) I have lost 20 lbs. I have a muscular body type, I am 54 years young , 5'4", weigh 137lbs (post menopausal) workout 5 days a week with crossfit, 1 day Yoga, and walk the dog 2 miles a day. I attribute the weight loss with eating more protein. I now eat almost 120 gms a day where before I probably only got 50-70 if that (did not track) . My protein sources are usually chicken , smoked salmon, tuna, turkey, once a week red meat. I do add pure protein bars (20gms) towards the end of the day when protein levels aren't there yet. I went to the doctor and got bloodwork done and my cholesterol went up. It went from the total 226 to -244, LDL-101 to 131, to HDL-105 to 101, ratio-2.1 to 2.4, Triglycerides-61 to 62 from Sept of 2020 to Sept 2021. ugh I know I should probably ignore it because my ratio seems great and I feel great. For some reason its bugging the crap out of me, how can I lose weight and eat more protein and have the numbers go up? Should I be concerned? Thanks you both rock. 3. Butyrate and Tributyrin for Gut Health [25:37] Ruby says: Hi Robb! Long time listener here (yeah! #throwback to Greg days) and current LMNT lover. I came across a supplement that uses a combination of Tributyrin and Vitamin D, and supposedly promotes a healthy gut, aids in healing leaky gut, helps reduce bloating, improves digestion and vitamin absorption, boots immune system etc. etc. etc. What they say is that Tributyrin has been used in Spain for at least 3 years but is just starting to come to the US. There are some studies on mice but not a ton in humans yet. I'm just wondering if you've done research on Butyrate/Tributyrin and whether or not you'd suggest experimenting with something like this. I am mostly paleo for about a decade, but my belly pooches out a ton (granted, I've had 2 kids and I'm working on core function), I haven't had consistent bowel movements in months, and while my stress levels are somewhat high because I'm an entrepreneur, I get 7 hours of sleep a night and do my best to keep myself regulated. I've tried probiotics, drink kombucha, try to get resistant starches (hate fermented foods unfortunately) and am pretty well versed in diet/health (thanks in large part to you!). I'm interested in trying out this supplement but very wary of putting anything in my body that is unknown and I can't find much info from people I trust (like you) on this particular topic. So I guess my question is twofold - what do you know about Butyrate/Tributyrin and also, how to decide what is safe to experiment with? Thanks so much for dealing with all the BS out there to provide information to all of us. Tributyrin, a Stable and Rapidly Absorbed Prodrug of Butyric Acid, Enhances Antiproliferative Effects of Dihydroxycholecalciferol in Human Colon Cancer Cells 4. Strength/aerobic/flexibility targets after age 50 [33:26] Jen says: Hello Robb and Nicki, I'm currently working as a health coach in a small clinical study to reverse cognitive impairment with “integrative therapy and lifestyle rehabilitation”. Can you point us to any reliable strength, aerobic, and flexibility benchmarks for men and women over 50? Ideally, the fitness assessment could be done at home without special equipment. It could be useful for participants to develop greater awareness of their relative fitness. Some seniors feel great about their occasional walks in comparison to their physically-deteriorated, sedentary peers. But, outside of my health coaching sessions, the doctor will plainly state that just “walking isn't cutting it.” For brain health, it could me most therapeutic for them to engage in complex, cognitively challenging physical activities, such as dance, martial arts, or sports (at an appropriate level), and check to see what supplemental exercise is needed to meet cardio, muscular, and flexibility targets. The fitness assessments I found from the Mayo Clinic https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/fitness/art-20046433 seem questionable in that both men and women at age 65 have the exact same target of 10 classic pushups. Does the upper body strength differential between the two sexes really disappear by age 65? I couldn't find an especially good resource for ages 50-90. For instance, the Fullerton Functional test/Senior Fitness test has arm curls as the best assessment of upper body strength. The presidents challenge at health.gov has assessments for students but not elders. If people want to be physically functional and free from chronic illness at a ripe old age, shouldn't they have be able to look for what needs attention at age 55, 60, 65, etc? I'd so appreciate your thoughts! With tons of respect and admiration!! https://moveskill.com/athletic-skill-levels/ 5. Itching after Jiu Jitsu Class [39:47] Ryan says: Hi Robb and Nicki, Big fan of your work! I've been training jiu jitsu (nogi) for about 6 years and absolutely love it… except for the fact that every morning after training I experience uncontrollable itching on my body, predominately my legs, but sometimes all over. I generally train in the evening, so the onset is about 10-12 hours after my session. This has been frustrating to say the least. I've read that this can be a problem for exercisers due to sweat… but that sounds iffy to me, plus I never had an issue with other forms of exercise, just jits. I've tried probiotics and different soap/laundry detergent to no avail. The only thing that semi helps is to shower immediately after the itching begins or sweat it out. Usually subsides after about 30-60 minutes… Any thoughts? Oss! Ryan Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte packets to keep you at your peak! They give you all the electrolytes want, none of the stuff you don't. Click here to get your LMNT electrolytes Transcript: https://robbwolf.com/2021/10/08/fitness-targets-after-50-butyrate-for-gut-health-protein-and-cholesterol-thrr090/
For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page
In Biohacking, we often have to choose between safe, effective, and affordable. But, after reading The Ultimate Guide to Methylene Blue by Mark Sloan of EndAllDisease.com I'm thoroughly convinced that Methylene Blue measures up in all three crucial dimensions, I'll be adding it to my daily stack. In this interview with the author we discuss...2:35 The holy grail of Biohacking - Safe, effective, and affordable4:04 What people are saying about Methylene Blue6:51 Vs Nitric Oxide: A toxic free radical11:05 Nitric Oxide vs testosterone12:08 A nicotine cofactor? 18:55 L-Arginine and Viagra are problematic23:09 Vs COVID33:55 Methylene Blue sources38:36 Methylene Blue as a “bio-prep”41:46 Dosage and usage47:48 What's in the book52:37 Red light therapy synergyRead my Methylene Blue Meta-Analysis - Everything mentioned herehttps://www.limitlessmindset.com/nootropic-ingredients/286-methylene-blueOrder book: The Ultimate Guide to Methylene Bluehttps://amzn.to/3AuH179Order Methylene Bluehttps://www.limitlessmindset.com/Methylene-BlueConfused?If you invest at least $100 in your Biohacking via LimitlessMindset.com, I will include a 30-minute free Biohacking consulting call with you. See my recommended Nootropics sources and Biohacking products here:https://www.limitlessmindset.com/membership/secret-societyForward a receipt of at least $100 to Consultations@LimitlessMindset.comJoin the Limitless Mindset email newsletterhttps://www.limitlessmindset.com/membership/community-membershipSupport My WorkMy bookshttps://www.limitlessmindset.com/jr-booksDonate cryptocurrencyhttps://www.limitlessmindset.com/support#cryptocurrencyConnect with Jonathanon Facebookhttps://www.facebook.com/limitlessmindseton Twitterhttp://twitter.com/jroselandon Instagramhttps://www.instagram.com/roselandjonathan/on Gabhttps://gab.com/jroselandon Mindshttps://www.minds.com/jroselandon LBRYhttps://lbry.tv/@jroseland:fon Telegramhttps://t.me/limitlessjrI'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health.
Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - http://bit.ly/3nHbNTs • Plain (Unflavored) - http://bit.ly/3as0x9U Take Dr. Berg's Free Keto Mini-Course! What are the benefits of l-arginine, and what are the cons? Find out. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Twitter: https://twitter.com/DrBergDC Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C
Kanda nitrik oksit salınımını arttırarak erkeklerde cinsel performansı ve sporcularda egzersiz performasını arttırdığı söylenen bu amino asidin etkileri gerçek mi hayal mi?
Nitric oxide (NO), a colorless gas, has been discovered and used for decades. In 1998, the Nobel Prize for Medicine went to Drs. Furchgott, Murad, and Ignarro for their discoveries leading to understanding NO. Inside the body, NO can relax the smooth muscles like that of the arteries. For instance, nitrates and nitrites have been used to decrease angina. Relaxing the smooth muscles of the veins and arteries decreases the load on the heart. That's how it decreases the pain of angina. This effect of NO also makes NO useful against high blood pressure and erectile dysfunction. L-arginine and citrulline are metabolic precursors of NO. In this podcast, we'll cover some studies dealing with L-arginine and citrulline as supplements.For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's blog articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page
In this week's podcast, we discuss nitric oxide (NO) boosting supplements L - Arginine and L - Citrulline better known as pre-work out. (Topic of the podcast starts at the 9 minute mark). Why would you want to "boost" your nitric oxide levels? NO is responsible for that pumped feeling in the gym. Increasing NO will allow more oxygen to get to the working muscle, allowing you to work harder for longer. More blood flow means moving more nutrients to the muscles and moving breakdown products out of working muscles faster. This will result in better recovery from increased nutrient delivery on top of a better pump and better performance. How is NO produced in our body? It’s primarily produced from amino acids. The two amino acids used to boost NO levels are L arginine and L citrulline. These two amino acids are closely linked. When we consume arginine, the body breaks it down using an enzyme called nitric oxide synthase into a gas called nitric oxide and citrulline. That newly created citrulline then heads to the kidneys to get reconverted back into arginine. It's a cycle that’s continuously happening in the body. When we consume citrulline alone, it goes straight to the kidney to get converted into arginine. The real benefit of these supplements is the nitric oxide gas they produce. This increases blood flow throughout the entire body. It causes vasodilation, meaning an increase in the size of our blood vessels, allowing more blood to flow through our body. More blood means more oxygen and more nutrients. To learn more about the benefits of increased nitric oxide, which supplements to take to most effectively raise nitric oxide levels in the blood, and the best dosing protocol, listen to this week's podcast. Website: https://tntwellnessandnutrition.com Email: tntwellnessandnutrition@gmail.com Itunes: itunes.apple.com/us/podcast/tnt-w…d1428217037?mt=2 Google Play Music: https://play.google.com/music/listen#/ps/Ibnzgb5hwnwd2aymtaixp6lvee4 SoundCloud: @user-422365757-83307870 Stitcher: https://www.stitcher.com/s?fid=445098&refid=stpr Social Media Links Twitter:twitter.com/tnt_wellness Facebook:www.facebook.com/tntwellnessandnutrition/ Instagram:www.instagram.com/tntwellnessandnutrition/ YouTube:https://www.youtube.com/channel/UCXb2pCmzu6JxW27bunmFytQ?view_as=subscriber
On Galway Talks Keith is joined once again by Polly from Evergreen Healthfoods who talks about taking calcium or glucosamine for bones and joints. Polly has advice for hay fever sufferers and suggests a course of action that could be effective for psoriasis. She also explains what L-Arginine is used for and the health benefits of fennel tea. Listen here to ‘Good Health Naturally’ with Evergreen Healthfoods on Galway Talks with Keith Finnegan.
Gorilla Mode Nitric Pre-Workout is the most potent and comprehensive stimulant free pre-workout on the market in ALL aspects. All angles of saturating the muscle with blood and hydration have been addressed in this formula and are quite literally maxed out. https://youtu.be/iFlmwQXBs6U Gorilla Mode Nitric Supplement Facts Per Full Daily Dose: L-Citrulline – 10,000 mg Creatine Monohydrate – 5000 mg Betaine Anhydrous – 4000 mg GlycerPump™ (65% Glycerol Powder) – 4000 mg Malic Acid – 3000 mg Agmatine Sulfate – 1500 mg Nitrosigine® (inositol-stabilized arginine silicate) – 1500 mg Sodium Nitrate – 1500 mg VasoDrive-AP® (isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) isolated from hydrolyzed milk casein) – 254 mg Gorilla Mode Nitric Vs. Other Pre-Workouts On The Market This is the most maxed out stimulant free pre-workout formula on the market in all aspects. It is also the most comprehensive formula that targets nitric oxide (NO), vasodilation and intracellular hyper-hydration from multiple angles, while maintaining top end dosages across all of those pathways. We completely saturate the traditional Arginine–eNOS–nitric oxide (NO) pathway with a massive 10 gram dose of L-Citrulline, 1.5 grams of Nitrosigine and 1.5 grams of Agmatine Sulfate. The often neglected nitrate–nitrite–nitric oxide (NO) pathway is also topped out with a 1500 mg dose of Sodium Nitrate. A high level of intracellular hyper-hydration is achieved with 5 grams of Creatine Monohydrate, 4 grams of Glycerpump and 4 grams of Betaine Anhydrous. We also addressed the enzyme angiotensin converting enzyme (ACE) with VasoDrive-AP®, which acts as an ACE inhibitor and significantly increases vasodilation. Finally, we have 3 grams of Malic Acid added in on top of the 10 grams of pure L-Citrulline to act as a Krebs cycle intermediary and counter lactic acid buildup during training. Some of these pathways are so maxed out that we could have easily just chosen one of them and sold the product for $39.99 and still had one of the most potent pre-workouts in the industry. Instead, I packed it all into one absurd product that clocks in with over 30 grams of efficacious active ingredients per full dose. It was incredibly expensive to create, but I am very happy with how it turned out, and I am not exaggerating when I say that this pre-workout is absolutely unmatched. Basically, I just included exactly what I would want to see in a stimulant free pre-workout, even at the obvious detriment of our margins. This product is even more potent than Gorilla Mode when it comes to pure pump and performance. The full daily dose is 2 scoops. Even a half dose (1 scoop) is still far more potent than the majority of other pre-workouts out there at their max dosages. This is another product I wanted to be head and shoulders, clear as day, superior to everything else in the industry. Just like in my description of how Gorilla Mode stacks up to other products in this industry, we can actually back up why our product is better than the rest. When (insert fitness influencer name here) launches their own supplement line, they will regurgitate the same story about how their products are effectively dosed, only use the highest quality ingredients, blah blah blah. They don't even know what they're selling half the time, let alone what combinations of ingredients work synergistically, or how to dose a product properly. They employ others to manufacture their products, or use a pre-made formula their manufacturer uses for every company where they just slap a different label on it and sell it for a huge margin. At the end of the day, most fitness influencers have no idea what goes into making an effective product. They don't know how their products work, they probably wouldn’t even use them if they didn’t sell them, they didn't formulate them, and they have to pay the overhead involved with having a team under them who is responsible for all of that. As you’ve already experienced with Gorilla Mode and Gorilla Mind Nootropics, it is me formulating the products, and they work because I actually put in them what I would want in a product and buy myself if I didn’t have a company. The same applies with Gorilla Mode Nitric. If I didn’t have this product, for an effective stim-free pre-workout I would probably be mixing up 6000-10,000 mg of L-Citrulline for vasodilation (with 6000 mg being the bare minimum of pure L-Citrulline, not Citrulline Malate, and would be dependent on my budget at the time), a saturation dose of Creatine Monohydrate (5000 mg), 3000-4000 mg of Glycerpump to hyper-hydrate the muscle with water, and maybe a quarter teaspoon of Himalayan Pink Salt. The fact that a significant amount of supplement companies will skimp out on Creatine Monohydrate and either not include it at all, or only include a subpar dosage, really sheds light on how scammy this industry can be. That is the cheapest ingredient they could easily dose properly, and even that they won't shell out the money for in their formulas. It’s not hard to put 5 grams of Creatine in a pre-workout, and it is actually pretty cheap to put in there. The reason is, they want you to go buy their creatine product, and will intentionally manipulate their ingredient profile to be deficient in several areas to make you buy more stuff from them. With my products, everything is turnkey. You don’t need to go buy a separate Creatine product from us, you don’t need to stack extra stims on top of our stim-based products, you don’t need to go buy something else to get the max dose of a certain ingredient in any of our formulas, everything you need is in each product at an efficacious dosage. Flavor And Mixability The flavor we chose to start with for Nitric was Mango Peach as it is a more mainstream appealing flavor than Tiger's Blood. Tiger's Blood and a fruit punch flavor will probably be next in the pipeline of flavor releases. Mango Peach is easily a 9 or 10/10 flavor, even for the pickiest of tongues. As there’s such a high concentration of ingredients in this formula we were really happy with how the flavor systems turned out. We were expecting something this potent to be nearly impossible to avoid tasting like ass. Fortunately, that wasn’t the case. It also mixes very well considering the concentration of L-Citrulline, GlycerPump, and all of the other ingredients in this product. There is some grittiness, but that just comes with the territory with putting out a 35 gram serving size product with 10 grams of L-Citrulline and 4 grams of Glycerpump. You will just have to use a bit more water than you would with your standard pre-workout because there are simply more active ingredients in this product that will require more liquid to mix well. How To Dose Gorilla Mode Nitric Mix 1-2 scoops of Gorilla Mode Nitric in 12-14 ounces of water and consume 30 minutes prior to training. Vary the amount of water to achieve your desired flavor level. First time users should begin use with 1/2-1 scoop or less to evaluate tolerance. DO NOT EXCEED 2 SCOOPS IN ANY 24 HOUR PERIOD. Gorilla Mode Nitric Ingredients Breakdown L-Citrulline – 10,000 mg L-Citrulline is the most effective supplement you can use to boost nitric oxide (NO) in the body. Why Nitric Oxide (NO) Is Important Nitric oxide (NO) is made naturally in our bodies and plays a significant role in cardiovascular health. It dilates blood vessels (vasodilation), which lowers blood pressure and increases oxygen in the blood. https://youtu.be/EoYhQIHmKoE Nitric oxide (NO) acts as a messenger to signal blood vessels to dilate, or contract and relax. Sufficient nitric oxide is needed to signal blood vessels to contract or relax to ensure blood is able to flow to and from the heart effectively. Nitric oxide production decreases with age, consequently reducing the elasticity of the cardiovascular system, and impairing the body's ability to ensure sufficient amounts of oxygenated blood are reaching vital organs. Eating enough nitrates and/or supplementing with nitric oxide precursors is very important to ensure that your cardiovascular system maintains optimized function as you get older. In addition, maintaining optimal nitric oxide levels will make you more vascular, allow you to get a much better pump, increase muscle volume, enhance the delivery of oxygen and nutrients to working muscles, support recovery and improve overall physical performance. Increased Muscular Endurance Citrulline has also shown to significantly increase muscular endurance, with one study finding that compared to placebo, a single 8000 mg dose of Citrulline Malate increased the number of reps performed per set, on every set after set 2 [R]. The impact Citrulline had on performance increased the more sets were performed. During the last set performed, the group that took Citrulline had a 52.92% increase in the number of reps they could perform relative to placebo. It also decreased muscle soreness by 40% at 24 and 48 hours after the training session compared to placebo. Effect On Body Composition There isn’t much data on the direct effect Citrulline has on muscle growth and fat loss in humans. However, a rodent model assessed the effect Citrulline had on body composition and found that 20 month old rats that were given a diet that included the human equivalent dose of 160 mg/kg per day for 12 weeks had 13% less body fat and 9% more lean body mass relative to the rats fed a standard diet without Citrulline supplementation [R]. Visceral fat mass was also reduced by 32%. The mortality rate of the rats taking Citrulline was 0%, while the standard diet fed rats had a mortality rate of 20%. L-Citrulline is one of the most promising supplements on the market and has significantly more upside above and beyond its increase in vascularity and pumps in the gym. The Maximum Effective Dose Of L-Citrulline Citrulline is found in watermelons. You would need to eat 1.5 kg of watermelon every day to get 3 grams of L-Citrulline though, which is the minimum effective dose [R]. To get the maximum effective dose of L-Citrulline from your diet, you would need to eat 5.0 kg of watermelon per day to get 10 grams (10,000 mg) of L-Citrulline [R]. Obviously, nobody is going to eat that much watermelon, nor is it a good idea to begin with in my opinion when there are far better ways to allocate your macronutrient/micronutrient intake allotments. This is why L-Citrulline supplementation could actually be worthwhile. The Problem With Citrulline Malate In The Supplement Industry While L-Citrulline is a great supplement to have in your daily regimen, there is a red flag around L-Citrulline supplementation that you need to know about. I'm sure you've seen that some supplements have L-Citrulline in them, and some have Citrulline Malate. Some even say "L-Citrulline Malate". This is a cheap trick companies use to deceive customers. Citrulline Malate is composed of 50% Malic Acid, unless the ratio states otherwise. Authentic Citrulline Malate is produced by chemically bonding free-form L-Citrulline to DL-Malic Acid. When L-Citrulline is chemically bonded to DL-Malic Acid, the end result is Citrulline Malate, which has unique properties. But the problem with the Citrulline Malate in the supplement industry is that it doesn't have this chemical reaction. It's just Citrulline mixed with malic acid in a big mixing vat in the manufacturing facility. There is no chemical bond like there should be to create authentic Citrulline Malate. It's just the two ingredients being mixed together in a cheap blend, and it's sold as "Citrulline Malate", or "L-Citrulline Malate". The reality is that it's just Citrulline stirred up with malic acid. While this isn't a huge deal in itself, the problem lies in the labeling practices companies use to artificially inflate the perceived potency of their product. 6-8 grams is seen as the max clinically proven efficacious dosage in the supplement industry in general. At least, that's what companies will tell you in their marketing. First of all, we already know that the actual maximum efficacious dosage of L-Citrulline is 10 grams per day [R]. In addition, the main issue is that the "L-Citrulline" in their product is actually as low as half of the stated label claim. As mentioned, Citrulline Malate is just a mixture of Citrulline and malic acid. Somehow, companies are getting away with labeling their products with the chemically bonded form Citrulline Malate and claiming they have 6-8 grams per serving in their pre-workout, when they actually just have 3-4 grams of Citrulline and 3-4 grams of malic acid per serving. Instead of labeling the following: L-Citrulline - 3 grams Malic Acid - 3 grams These companies are labeling their products like this: Citrulline Malate - 6 grams Or like this: L-Citrulline Malate - 6 grams Making you think you are getting a high dose, when in reality you are getting the bare minimum efficacious dose per serving of 3 grams. Sometimes, companies will tweak the ratio to be a bit more in favor of a higher Citrulline content relative to malic acid, but this is rarely higher than a 2:1 ratio. So, if you see the following: Citrulline Malate (2:1) - 6 grams That just means that the company has 4 grams of L-Citrulline and 2 grams of malic acid per serving. This is the exact manufacturing process involved in producing the L-Citrulline and "Citrulline Malate" you get in pre-workouts in the supplement industry: As you can see, the Citrulline Malate manufacturing flowchart on the right literally just says, "mix". If this was authentic Citrulline Malate, you wouldn't need to mix L-Citrulline with malic acid, it would be chemically bonded together by the end of the manufacturing process. You're not really getting what you're paying for, and most don't realize this is a tactic in the industry to get better margins and artificially inflate a products perceived efficacy. Even if a pre-workout had what on paper appears to be a top end efficacious dose of 8 grams per serving, how much L-Citrulline are you actually getting out of that serving? 4-6 grams at most. I have yet to see a pre-workout formula actually hit a top end L-Citrulline dosage, and of the ones that get close, they use Citrulline Malate to inflate their label. In addition, even if you had the bonded version (which supplements don't), reacted Citrulline Malate will break apart into L-Citrulline and malic acid right away after its mixed in water. It's all just a trick to artificially inflate a products perceived potency on a label, as each ingredient should be listed separately. Most supplements have malic acid anyways in the "other ingredients" section, which is still an active ingredient that does have some potential performance benefits that you would get from the “Malate” portion of Citrulline Malate. L-Citrulline and malic acid work via a different mechanism of action. Citrulline bypasses the liver and gets converted to arginine, which increases NO levels in the body. Malic acid is a Krebs cycle intermediary that counters lactic acid buildup. How much do you need of each though? With Citrulline, we know where the top end data lies. Malic acid, we don't. There is research on Citrulline and Citrulline Malate, but not much data on supplementing with malic acid to replenish depleted levels as a Krebs cycle intermediary. I don't think we can make a generalized overview on how effective the malic acid component was in the Citrulline Malate research either because we can't determine if the results were derived from the malic acid, the L-Citrulline, or both. Considering this, I included an additional 3000 mg of malic acid separately in the Gorilla Mode Nitric formula as an active ingredient in the main ingredients panel. As mentioned, malic acid is most commonly used as a filler in supplements, and will be found in small amounts in many product "other ingredients" sections. The only other time it is used is by companies artificially inflating their perceived L-Citrulline dosage via Citrulline Malate. No companies are including a maxed out dose of pure L-Citrulline as well as malic acid separetely though. It is always a subpar amount of each. So, if there is some sort of performance enhancing benefit to having a high dose of malic acid, you are also getting it via Nitric on top of the maximum efficacious 10,000 mg dose of pure L-Citrulline. At the end of the day, for vasodilation you should concern yourself with is how much pure L-Citrulline is in your pre-workout supplement. I have yet to see a product with more than 6000 mg of PURE L-Citrulline. I have only seen a handful of products with 6 grams of L-Citrulline, and another handful of products with 8 grams of Citrulline Malate (which only yields 4-5 grams of actual L-Citrulline, with the remainder as malic acid). I put 10 grams of PURE L-Citrulline in Gorilla Mode Nitric, as well as 3 grams of malic acid separately, so you can get the full benefits of the max dosage of each ingredient and transparently see exactly what you are actually getting in the product. Even if you decide to only use a half dose of this product you will still get 5000 mg of pure L-Citrulline, and the formula is still top notch even when cut in half. Citrulline Vs Arginine One of the most well-known pump ingredients is Arginine. The problem with L-Arginine is that it is very ineffective at increasing Nitric Oxide synthesis. Logically, you would assume that taking Arginine would be the most effective way to increase Arginine levels in the body. However, this is not the case. Oral L-Arginine is taken up and metabolized by the liver so much that it does not actually effectively increase Arginine levels, and it may even be unsafe to use because of how much excessive urea it yields [R]. L-Citrulline bypasses the liver and passes freely to the kidneys where it is metabolized to Arginine [R]. The most effective supplement that can be used to increase Arginine levels in the body to improve cardiovascular and metabolic health outcomes is L-Citrulline [R]. L-Citrulline supplementation has shown to lower blood pressure and provide atherogenic-endothelial protection [R]. When it comes to NO precursors that significantly improve pumps, nothing beats an efficacious dose of pure L-Citrulline. Creatine Monohydrate – 5000 mg Creatine is the best studied and most effective performance enhancing supplement outside of exogenous hormones and drugs. Creatine’s Effect On Muscle Size And Strength Supplementing with creatine has shown time and time again to significantly improve strength, power output and muscle size [R]. Creatine’s effect on strength is facilitated by increasing the body’s stores of phosphocreatine, which is then used during high intensity exercise to produce ATP [R, R]. Creatine’s effect on muscle size is facilitated by drawing water into the muscle via osmosis, consequently increasing body weight and muscle size. In addition, with the increased strength creatine provides, heavier weights can be used in the gym which provide more stimulus for growth, consequently increasing muscle accrual in the long-term. Creatine supplementation also appears to increase the number of myonuclei that satellite cells will donate to damaged muscle fibers, which increases the potential for growth of those fibers [R]. A typical omnivorous diet provides about 1 gram of creatine per day, which isn’t enough to get the benefits you would from supplementation, and also isn’t nearly enough to support health status and methylation in those with genetic polymorphisms. Creatine’s Effect On Methylation And Health Status About 1 gram of creatine is endogenously produced in the body naturally in young healthy adults [R]. Most of the human body's total creatine and phosphocreatine stores are found in skeletal muscle, while the remainder is distributed in the blood, brain, and other tissues [R]. While there are a host of processes in the body that rely on creatine to be carried out optimally (and are often completely neglected), one of the most notable functions of creatine is neurological support [R]. In addition, the endogenous synthesis of creatine relies on a process called methylation. Arginine and Glycine are combined by an enzyme to form guanidinoacetate, which is then methylated into creatine. The problem is that this process is dependent on a mechanism of action that is commonly inhibited in the general population via endogenous Arginine deficiency, Glycine deficiency, or MTHFR polymorphisms. The MTHFR gene codes for an enzyme called methylenetetrahydrofolate reductase or MTHFR. This enzyme is needed for the production of DNA and methylation pathways that are essential for all bodily functions. Genetic variations in this gene results in reduced activity of the enzyme and has been associated with cardiovascular disease, neurological defects, some forms of cancer, and a myriad of other diseases and disorders [R, R]. Personally, I am homozygous for C677T of MTHFR, which results in a 80-90% decrease in my efficiency in processing folic acid. The direct reflection of that in blood biomarkers can be high homocysteine and low B12 and folate levels. I determined this via a simple 23andMe genetics test. Upwards of 45% of your body’s methylation demands are used to synthesize creatine. For someone with a MTHFR polymorphism, you can put a significant amount of stress on your methylation pathway and deplete far more methyl groups than you should be just to create the 1 gram per day that you endogenously synthesize. We lose up to 2-3 grams of creatine per day because it converts to creatinine and is then passed out of the body via urine. As you can see, adequate replenishment of creatine is probably not being accomplished if you aren’t consistently eating a fair bit of meat or fish. And for those with impaired methylation pathways, supplementing with exogenous creatine is likely the only way creatine replenishment can be achieved. One study found that supplementing with 5 grams of creatine per day lowered plasma homocysteine levels by almost 50% in the subject who is homozygous for C677T of MTHFR [R]. Creatine supplementation can significantly lower the body’s demands for methylation and prevent the depletion of methyl groups. This is why I personally supplement with 5 grams of creatine per day. Do You Need To Cycle Off Of Creatine? No, you do not need to cycle off of creatine. Your body does not get used to it, and long-term use has shown to be safe in healthy adults [R]. Betaine Anhydrous – 4000 mg Betaine, also called Trimethylglycine, acts as a methyl donor and an osmolyte in the body. Earlier in the creatine breakdown, I briefly outlined the importance of having a sufficient amount of methyl donors available for methylation processes in the body, including the endogenous synthesis of creatine. For some individuals (depending on PEMT gene variations) Betaine can substitute for folate and B12 in the regeneration of methionine and can be choline sparing via this mechanism. It can also provide additional needed methyl donors when over-depletion occurs in genetically predisposed individuals that do not supplement with creatine, or have other deficiencies. As an osmolyte, Betaine helps balance fluid levels inside and outside of cells. The main reason I included Betaine in this formula is for its ability to induce intracellular hyper-hydration. By improving hydration status in cells, Betaine increases the pump you get in the gym, and can help prevent dehydration during exercise. Research has also shown that Betaine supplementation may reduce the risk of cardiovascular disease, as well as improve digestion and liver function [R, R, R, R]. In a performance enhancing context, Betaine supplementation has also shown to increase power, endurance, muscle growth and fat loss [R, R, R]. How significant will this effect on body composition be in practical application? Negligible in my honest opinion, but the enhanced pump made this ingredient worthwhile to add into the formula. GlycerPump™ (65% Glycerol Powder) – 4000 mg Glycerol significantly enhances pumps and performance by hyper-hydrating the muscle with water. Glycerol’s Effect On Hydration, Pumps And Endurance If you drink a lot of water with nothing else in hopes of hyper-hydrating your muscles, the fall in osmolarity in your body stimulates the kidneys to remove most of the excess water within an hour. If you add glycerol to the water, this prevents the drop in osmolarity and can extend the hyper-hydration of your muscles by up to four hours. By adding Glycerol to your pre-workout, you can hold upwards of an extra liter of water via this hyper-hydrating effect. Hydration is one of the most critical factors when it comes to performance. Aside from massive pumps, Glycerol use has shown to increase endurance by as much as 24%, as well as improve aerobic and anaerobic power and performance [R, R]. Only a 2% loss in fluids can result in as much as a 20% decrease in exercise performance. GlycerPump™ Vs Other Forms Of Glycerol We chose the trademarked GlycerPump because it doesn’t clump up nearly as much as other forms of Glycerol powder and it’s more stable. Glycerol is normally a liquid at standard temperature and pressure, and many supplement companies have attempted to create a powder form of Glycerol that is stable. Glycerol products get clumpy, have horrible viscosity and have a short shelf life. Because of this, most companies avoid this ingredient entirely, as it can cause severe clumping within just a couple months of being manufactured. Regular glycerol containing products only yield as low as 10% glycerol, which makes them ineffective, and higher yielding glycerol products can be unstable within complex formulas like ours and result in a clumpy product, or complete product failure. GlycerPump™ is created using unique spray drying technology, yielding a stable powder form of glycerol standardized to 65%. It is MUCH better than other alternatives and won't result in the powder turning into a rock. Keep in mind, while it is manageable, this is not a clump-free product, and there’s nothing I could do about that if I wanted to include the high concentration of ingredients that I did in Gorilla Mode Nitric. Store Gorilla Mode Nitric in a cool dry place, and if it clumps, that’s just what comes with the territory with a product dosed like this. If it clumps, just get out a knife or spoon and chop it up, and it will still mix fine once it hits the water in your cup. Agmatine Sulfate – 1500 mg Agmatine has shown to induce NO production via the same processes as arginine, but does it far more effectively [R]. This results in even bigger pumps in the gym and improved overall performance. Agmatine has also shown to be neuroprotective against excitotoxicity and stroke, and also has anti-anxiety and anti-depressant effects that may enhance state of well-being and mood elevation with supplementation. Agmatine has also shown to manipulate pain receptors, which may result in an increased pain tolerance during intense training. Agmatine is a very misunderstood compound and is believed by some to antagonize other vasodilators. Agmatine works in a more selective way than other vasodilators, as it only increases one of the three Nitric oxide synthase (NOS) isoforms. It also decreases the other two NOS isoforms, which is where the hypothesis about it being vasoconstricting was raised as a legitimate concern. The three NOS isoforms include iNOS, nNOS and eNOS. They each play their own role in certain tissues to regulate vasodilation. iNOS (inducible) produces high concentrations of NO via an immune system response to kill harmful bacteria. In excess, iNOS can be inflammatory. nNOS (neuronal) regulates neurological health and facilitates communication in the brain across neurons. In excess, nNOS can inhibit the growth and repair of neurons. eNOS (endothelial) facilitates vasodilation in the lining of blood vessels to improve blood flow. eNOS is the main isoform that most are familiar with that increases blood flow and lowers blood pressure. It is also the main isoform that facilitates massive pumps in the gym. While NO is great for the gym and vascular health, it can be inflammatory in excess. NO production by eNOS has shown to play a protective role in cerebral ischemia by maintaining vascular permeability, whereas NO derived from nNOS and iNOS is neurotoxic and can enhance the neuronal damage occurring in ischemia [R]. This is where the selective activity of Agmatine shines, as data suggests that Agmatine's mechanism of action is facilitated by inhibiting iNOS and nNOS and increasing eNOS [R, R]. Agmatine has shown to selectively increase eNOS levels while simultaneously decreasing iNOS and MMP-9 protein expression [R, R]. Anecdotally, Agmatine does not seem to inhibit any of the positive effects of L-Citrulline or other vasodilators. On the contrary, it seems to complement other "pump" compounds very effectively. On paper, Agmatine sounds like the perfect ancillary compound to add to a pre-workout as it increases expression of the NOS isoform we want, while simultaneously inhibiting the isoforms that can be more inflammatory in excess. Nitrosigine® (inositol-stabilized arginine silicate) – 1500 mg Nitrosigine got some hype behind it when independent researchers from the University of Arkansas presented data suggesting that 1500 mg of Nitrosigine was almost as effective as 8000 mg of Citrulline Malate 2:1 (5333.33 mg L-Citrulline and 2666.66 mg Malic Acid) at increasing flow mediated dilation (FMD) [R]. FMD refers to dilation of an artery when blood flow increases in that artery. Because the primary cause of FMD is release of nitric oxide by endothelial cells, we can use FMD as a proxy for NO levels. To circumvent the lackluster efficacy of plain oral Arginine, Nutrition 21 (the developers of Nitrosigine) created a complex of bonded arginine and silicon. The inositol acts as a stabilizer and increases the bioavailability of the complex, consequently resulting in a potent NO boosting compound. Remember that the main issue with Arginine is poor bioavailability. The inositol stabilizer helps circumvent that issue [R]. Unlike plain Arginine, Inositol-stabilized Arginine silicate (Nitrosigine) has shown to kick in within 15 minutes and elevate blood Arginine levels for up to six hours after ingestion [R, R]. Nitrosigine has some impressive data reinforcing its efficacy, and it is purported to be much more effective milligram for milligram than other common vasodilators at increasing NO levels. On top of the increase in vasodilation and pumps, the developers claim that after a single dose Nitrosigine can increase mental acuity and focus by 33% within 15 minutes, with a compounding effect over time. In addition, they claim that Nitrosigine supports enhanced recovery by reducing markers of muscle damage [R]. Nitrosigine Vs. L-Citrulline Vs. Agmatine Sulfate In Vitro An in vitro study was designed by Nutrition 21 to compare the cellular production of NO of several sports nutrition ingredients. These ingredients included Nitrosigine, L-Arginine, L-Arginine AKG, L-Citrulline, Citrulline Malate and Agmatine Sulfate. Nitrosigine was dosed at a concentration of 1.0 g/L. Cell culture concentrations of the other compounds were dosed relative to a 1500 mg dose of Nitrosigine using the following doses: L-Arginine - 1500 mg L-Arginine AKG - 4000 mg L-Citrulline - 3000 mg L-Citrulline Malate - 3000 mg Agmatine Sulfate - 1000 mg As NO is unstable and rapidly converts to nitrites or nitrates, nitrite levels were measured as a proxy for NO production. At the doses used in this study, Nitrosigine significantly increased NO production over each of the five other compounds tested. There was a greater than 5X increase in NO production with Nitrosigine compared to the other tested vasodilators. In addition, of the compounds tested, only Nitrosigine significantly increased NO production versus control. While this looks very impressive for Nitrosigine, you have to consider that this is an in vitro study conducted by Nutrition 21 themselves. The results basically indicate that every single clinically proven vasodilator that we know works is useless as it couldn't increase NO production above control, meanwhile Nitrosigine somehow cranked it through the roof over 5x higher than the rest. While the results are certainly interesting, I would take this data with a grain of salt. Nitrosigine Vs. Citrulline Malate - Vasodilation Study On Young Adults Unlike the in vitro study comparing Nitrosigine to Citrulline Malate, another study in 2019 was apparently conducted independently from the company without their knowledge whatsoever [R]. This study was conducted on young, healthy, physically active adults, and provides more acceptable parameters for us to take seriously when it comes to evaluating Nitrosigine's efficacy in humans relative to a decent dose of the most widely used vasodilator in the industry, Citrulline Malate (assuming that the study was actually unbiased as is implied) [R]. 16 healthy young men and 8 healthy young women participated in the study. Each subject either received 1500 mg of Nitrosigine, 8000 mg of Citrulline Malate 2:1, or dextrose placebo. Keep in mind, this is Citrulline Malate 2:1, so the subjects are only actually getting 5333.33 mg of L-Citrulline. The study was randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline flow mediated dilation (FMD) measurement was obtained for each visit, followed by consumption of one clinical dose Citrulline Malate (8 grams), Nitrosigine (1.5 grams), or dextrose placebo (8 g). Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects. Basically, the subjects would show up, get their FMD evaluated, take one of the three options, and then get their FMD checked again to see how well the random compound they ingested increased their NO production. They would then take a week off, and come back and repeat, where they would then receive one of the remaining two compounds, with the same measurement process. This would be followed by another week off, and then a third visit where the subjects would receive whatever the third ingredient was that they hadn't yet tried, and the same measurement process was conducted. Nobody knew what they were ingesting during each trip, but by the end of the experiment every single subject had tried each ingredient, and their vasodilation response was evaluated for comparisons. Expectedly, Citrulline Malate and Nitrosigine yielded a greater improvement in FMD response than placebo. Citrulline Malate increased FMD by 34%. Nitrosigine increased FMD by 31%. Placebo decreased FMD by 2%. Allometric scaling of the FMD values was required afterwards to adjust the results to account for the body size of males relative to females. After allometric scaling of the FMD values, Citrulline Malate was shown to increase FMD by 25%, Nitrosigine increased FMD by 23%, and placebo increased FMD by 0.6%. Clearly Citrulline Malate isn't as useless as the Nutrition 21 funded in vitro data would lead you to believe. The results from this study suggest that the clinically efficacious 1500 mg dose of Nitrosigine is almost equally effective to 5333.33 mg of L-Citrulline mixed with 2666.66 mg of Malic Acid. Clearly Nitrosigine has a lot of promise as a pre-workout ingredient, which is why I included it in our formula alongside the massive dosages of other potent vasodilators we already have. Every single effective vasodilator we felt was worthwhile is in here at topped out dosages. While it would be nice if there was data we could refer to evaluating if there is a synergy between Nitrosigine and Citrulline, or Nitrosigine and Agmatine, regardless if the end result is 1+1 = 2 or if it's 1+1 = 3, my goal was to make sure this formula was air tight and ensure you are getting the maximum possible performance enhancing benefit from each and every ingredient. Sodium Nitrate – 1500 mg Sodium is one of the most critical and overlooked components of a diet designed to optimize exercise performance. But, keep in mind, you’re not going to get enough sodium in a pre-workout without it tasting terrible. Other companies will put a tiny dose of sodium in their product and then claim you will get all of the benefits of it. Personally, I just toss and wash a quarter teaspoon of a high quality salt 30 minutes pre-workout with Gorilla Mode or Gorilla Mode Nitric, and I take another quarter teaspoon with my post-workout drink. The reason I included sodium nitrate in Gorilla Mode Nitric is not for the sodium, it is for the nitrates. The nitrate–nitrite–nitric oxide (NO) pathway is a series of oxygen-independent and NO synthase–independent single-electron transfer reactions that ultimately facilitate vasodilation. The traditional Arginine–eNOS–nitric oxide (NO) pathway is what most NO precursors focus on. The nitrate–nitrite–nitric oxide (NO) pathway often goes completely neglected though, and is another pathway we can leverage to amplify NO levels to an even greater level. Nitrates found in food can be converted into nitrites in the body, and then reduced to NO via nitrite reductase [R]. Several studies have shown that nitrate supplementation can increase plasma nitrite concentrations, and consequently Nitric Oxide, which then enhances pumps, endurance, and all of the other benefits we use NO precursors for [R]. Nitrate Dosage - Sodium Nitrate Vs. Beet Root Powder Pre-Workouts Beet root is a very popular ingredient that has started to get a lot of attention over the past few years. The reason why beet root works is because it is a densely concentrated source of nitrates. However, despite it being densely concentrated relative to other foods, beet root still only contains 1-2 percent of nitrates per gram of raw material. This would require you to ingest an absurdly high amount of beet root to get the same amount of nitrates that you can get from the 1500 mg of sodium nitrate in Gorilla Mode Nitric. To put it in perspective, your standard beet root powder pre-workout supplement has around 4.3 grams of Beet root juice powder in it. The amount of nitrates in that 4.3 grams is about 43 mg. That means that you would need to chug the entire tub at one time to get the same amount of nitrate as you would get out of a 1500 mg dose of sodium nitrate. There is no feasible way to get a high dose of nitrates from beet root powder without ingesting massive quantities far higher than what you would get in a dietary supplement. By weight, sodium nitrate is the most highly concentrated source of nitrates among any dietary ingredient. Nitrates comprise 73 percent of the total weight of sodium nitrate [R]. The optimal dosage of nitrate supplementation appears to be between 6.4-12.8 mg/kg [R]. That equates to the following dosage protocols: 440-870 mg for a 150 lb person 580-1,160 mg for a 200 lb person 730-1,450 mg for a 250 lb person For every gram of sodium nitrate, 730 mg is from nitrate. The 1.5 grams of sodium nitrate in Gorilla Mode Nitric yields 1095 mg of nitrate. There are other nitrate based supplements in the industry like Arginine Nitrate, Creatine Nitrate, Betaine Nitrate that operate via this same nitrate–nitrite–nitric oxide (NO) pathway, however, none of them have as high of a nitrate composition gram for gram as Sodium Nitrate does. VasoDrive-AP® (isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) isolated from hydrolyzed milk casein) – 254 mg VasoDrive-AP consists of 2 lactotripeptides: isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) which are clinically proven to inhibit Angiotensin converting enzyme (ACE) and significantly increases vasodilation. Angiotensin converting enzyme (ACE) controls blood pressure by regulating the volume of fluids in the body. ACE facilitates this process by converting the hormone angiotensin I to the active vasoconstrictor angiotensin II. Angiotensin converting enzyme inhibitors (ACE inhibitors) inhibit ACE, consequently reducing angiotensin II production. Reducing angiotensin II results in the dilation of blood vessels and a reduction of blood pressure. Bradykinin is also a vasodilator in the body that is degraded by ACE. Clinical data suggests that individuals who genetically have lower levels of ACE respond better to training and are at an advantage in endurance sporting events [R, R]. The more blood flow you have, presumably the more oxygen and nutrient carrying capacity you will have during exercise. VasoDrive-AP has shown in 30 clinical studies to date a potent effect on vasodilation and blood pressure reduction via this mechanism completely independent from the traditional Arginine–eNOS–nitric oxide (NO) pathway [R]. Ingredients I Didn’t Include In The Formula And Why Vitamin C Vitamin C is a very potent antioxidant and plays a crucial role in lowering blood pressure and regulating health blood flow. Supplementing a Vitamin C deficient diet can be very beneficial, except when you're dosing it pre-workout. Vitamin C is inexpensive and has tons of clinical data to back its efficacy, so it is often thrown in pre-workouts. The problem with this is that using Vitamin C pre-workout can blunt the hormetic response to the workout itself and hinder your results [R]. The point of working out is to damage the muscle, which then results in the body signaling repair processes to start that will help you recover and ultimately get bigger and stronger to adapt to the workload. If you manually decrease that hormetic response to exercise by ingesting Vitamin C pre-workout, you will reduce the damage done and ultimately prevent your body from stimulating as much growth. Personally, I don't take any vitamins, anti inflammatories, or powerful antioxidants for several hours before or after my workout to be safe. Antioxidants And Vitamins As mentioned, one of the worst things you can do is take antioxidants before your workout. The stress and damage induced by weightlifting or exercise is needed to facilitate muscular recovery and progress. The reactive oxygen species and inflammation produced during intense training assists with that process, and is also why drugs like Ibuprofen can inhibit muscle growth so severely. The inflammatory response to training is what we want in order to recover, and by inhibiting that with antioxidants, vitamins or anti-inflammatory drugs, you prevent your body from breaking down and recovering the way it needs to in order to grow [R, R]. A pre-workout formula with a bunch of vitamins and antioxidants in it is more likely to hinder your gains than help. Potassium I advise reaching your recommended daily intake of 4,700 mg through diet rather than through supplementation. It is not legal to sell Potassium in high amounts, and you will usually find that supplements have no more than 100 mg or so per serving because of this. For this same reason, supplementation isn't cost effective, and pre-workouts with potassium in them are including it solely to claim the benefits of potassium all the while knowing the dose in their product is next to useless. The amount of potassium in pre-workout supplements does next to nothing for you when it comes to helping you hit the RDA. S7™ S7™ is a blend of green coffee bean extract, green tea extract, turmeric extract, tart cherry, blueberry, broccoli and kale that has gotten some hype in pre-workouts recently. I was considering including it in our formula until I saw that the blend was comprised entirely of potent antioxidants and anti-inflammatories. Turmeric is one of the most potent anti-inflammatory spices known to man, which is why it also shows such therapeutic promise via supplementation. However, the last thing you want to use pre-workout is a potent anti-inflammatory compound. Inflammation is what we are striving for during a workout, and using anything that significantly impairs this inflammatory response to training is something that should not be used pre-workout, and should be saved for taking far away from the peri-workout window. Beta Alanine Beta Alanine is the ingredient that makes your skin itchy and has you sitting there scratching your face between sets. I assume it is included in pre-workouts because you can blatantly feel something when you take it, so people associate feeling something with the product being potent. Personally, I can’t stand the itchy skin effect it has, and it can be bad enough that it ruins a pre-workout just based on that. In addition, it doesn’t have more than a negligible effect on performance at best. Acute sporadic bumps in Beta Alanine will do next to nothing if you are only getting your Beta Alanine dosage from your pre workout supplement a few times per week. If you were to take it correctly, dosing it multiple times per day, for weeks on end, at a high enough dosage, the impact on performance is notable, although still fairly insignificant at the end of the day. “The median effect of β-alanine supplementation is a 2.85% (-0.37 to 10.49%) improvement in the outcome of an exercise measure, when a median total of 179 g of β-alanine is supplemented” [R]. 179 grams (an amount nobody would end up getting in) for a 2.85% improvement in performance, and a ton of itchiness… “Although some laboratory-based studies show an ergogenic effect with beta-alanine supplementation, there is a lack of field-based research in training and competition settings.” “There was an unclear effect (0.4%; ± 0.8%, mean, ± 90% confidence limits) of beta-alanine on competition performance compared to placebo with no meaningful changes in blood chemistry. While there was a transient improvement on training performance after 4 weeks with beta-alanine (-1.3%; ± 1.0%), there was an unclear effect at ten weeks (-0.2%; ± 1.5%) and no meaningful changes in blood chemistry. Beta-alanine supplementation appears to have minimal effect on swimming performance in non-laboratory controlled real-world training and competition settings” [R]. Leucine Taking Leucine post-workout promotes muscle growth. However, taking Leucine in your pre-workout has shown to diminish muscular performance via the inhibition of glycogen to glucose conversion within muscle cells and insulin signaling. On top of that, Leucine can prevent the uptake of Tyrosine into the brain, consequently inhibiting dopamine production, which is the opposite of what we are trying to accomplish pre-workout. Should You Ever Cycle Off Of Gorilla Mode Nitric? Despite Nitric being stimulant free, I would still advise cycling your use of Gorilla Mode Nitric every once in a while. In general, I advise cycling your use of any supplement that isn't being used daily to replace a dietary deficiency. Interfering with balancing mechanisms in the body chronically long-term is almost always going to build up to some unintended negative side effect, and redlining your Nitric Oxide levels and vasodilation on a daily basis for long uninterrupted spans of time will probably be no different. How often you cycle it is ultimately up to your discretion as there is no tolerance build up with the ingredients in Nitric, and some of them actually have accumulative benefits. Personally, I use pre-workouts 4 days per week because I workout 4 times per week. Every month or two I will also take a full week off of everything except for my daily health supplements. How To Combine Gorilla Mode Nitric With Gorilla Mind Rush Gorilla Mode Nitric has no stimulants in it, so if you want the most potent combination of performance, energy, focus and drive pre-workout you can combine Nitric with Gorilla Mind Rush. Dose each product as you would normally dose them on their own, as there is no overlap between the two formulas. How To Combine Gorilla Mode Nitric With Gorilla Mode Gorilla Mode can be combined with Gorilla Mode Nitric to achieve a more middle road level of stimulants but with the maxed out vasodilation and hyper-hydration. The instance in which mixing the two would make the most sense is if you don't want to use a high dose of Gorilla Mode because the stimulant dosages are higher than you prefer or can tolerate, but still want to max out the benefits of the ingredients included for pump and performance. For example, if 2 scoops of Gorilla Mode contains too high of a dose of stimulants for you, you could use 1 scoop of Gorilla Mode with 1 scoop of Gorilla Mode Nitric. Or, a 1/2 scoop of Gorilla Mode with 1.5 scoops of Gorilla Mode Nitric. Alternatively, if you are using Nitric and want a little bump of stimulants but are too sensitive to the stimulant complex in Gorilla Mind Rush, then you might want to add a bit of Gorilla Mode to your Nitric dose as the blend of stimulants in Mode is a notch less aggressive than the stimulants in Rush. Mix and match at your own discretion based on your own stimulant tolerance and exactly what you are looking to get out of your pre-workout. Personally, I love combining Rush and Nitric pre-workout. Sometimes I will use Mode with Nitric instead though as the Kanna and N-Phenethyl Dimethylamine Citrate hits differently than the stimulants in Rush. It all depends on what I'm training, how well rested I am, and the effects I am shooting for. Conclusion - What To Expect From Gorilla Mode Nitric In general, you can expect a massive increase in nitric oxide (NO) levels, vasodilation, intracellular hydration and as significant of a boost in muscle strength and endurance as you can get from a legal non-hormonal pre-workout. This product is maxed out from all angles. The traditional Arginine–eNOS–nitric oxide (NO) pathway is completely saturated with an unheard of dose of L-Citrulline, as well as topped out doses of Nitrosigine and Agmatine Sulfate for good measure. Over a gram of nitrates also ensures that the nitrate–nitrite–nitric oxide (NO) pathway is taken care of. Intracellular hyper-hydration is best-in-class too with a huge dose of Creatine Monohydrate, Glycerpump and Betaine Anhydrous to volumize the muscle and support performance and pumps. Inhibiting the enzyme angiotensin converting enzyme (ACE) with a clinical dose of VasoDrive-AP® also checks off another pathway to push the boundaries on supraphysiological levels of vasodilation. Finally, a high dose of Malic Acid was included for good measure to act as a Krebs cycle intermediary and support greater levels of muscular endurance. Try Gorilla Mode Nitric for yourself here and let me know what you think.
As we age, human growth hormone decreases. I talk about the 8 top ways to increase HGH and anti-aging mechanisms naturally. They include Exercise, Ketosis, Intermittent Fasting, Hypoglycemia, Sleep, L-Arginine, Niacin, MyVitalC, Liquid Biocell Collagen, Meditation, and the Accelerated Thyroid and Radiation Detox supplements.
L-Arginine is one of the 20 amino acids in the body. As a supplement, research suggests that l-arginine benefits natural processes in the body. Two of its most important functions are to help build and repair muscle tissues and to release nitric oxide into the bloodstream for vasodilation. L-arginine is available in some of our foods, but when that’s not enough to satisfy the body’s needs, we can get it in supplemental forms. Buy l-arginine powder at BulkSupplements.com
Susan Bratton, the Dear Abby of sex, joins us again with six essentials for connected sex. Tune in to understand herb cycling and supplementation to support our sexual health against health issues that impact our sexuality, especially as we age. Susan also helps us be better communicators in and out of the bedroom. Something we can all use! * * * About Susan Susan is a champion and advocate for all who desire passionate relationships. Considered the Dear Abby of sex, Susan’s fresh approach and original ideas have helped millions of people of all ages and across the gender spectrum transform sex into passion. Married to her husband, Tim, since 1993, Susan is an author, award-winning speaker, and serial entrepreneur, who teaches passionate lovemaking techniques to her fans around the world. Susan has been featured in the New York Times and on CNBC and The Today Show, as well as appearing on ABC, CBS, The CW, Fox, and on NBC as the Marriage Magician. Susan is the Chair Emeritus of The AdTech Conference. She was both CMO and a member of the board of directors for an Anthony Robbins tech startup, as well as serving on numerous boards throughout her career. In 2009, Susan was honored as a Silicon Valley Woman of Influence by the Business Journal, and as a top 10 internet pioneer by Ad Age Magazine. In 2010, was bestowed the Lifetime Industry Achievement Award by DMG World Media. Susan talks about, after 25 years of marriage, “I know from experience that deep passionate intimacy with my partner is priceless, a priority that tops my list of must-haves, alongside good health and the love of family and friends. I have made it my mission to aide anyone who wants the kind of lovemaking that improves with age.” * * * Your Libido Is Your… Sex drive Creativity Passion Lust for live Vitality What Health Issues Impact Your Sexuality? Diabetes/Pre-Diabetes Neuropathy Loss of sensation Anorgasmia Heart disease Plaque in your arteries/veins Not enough blood flow to your penis Supplementation It took you this long to get sick, you’re not going to get healthy in a matter of days. We’re always working on our health because we’re always trying to reverse anti-aging, we’re trying to do anti-aging, we’re trying to reverse atrophy. Everything external is a reflection of internal, including our genitalia. Adaptogens/plant-based botanicals Support hormones Lower cortisol Increase testosterone Increase estrogen Manage aromatase expression of over-estrogen in men Supporting herbs Maca – libido support Cacao – polyphenols Nitric oxide precursors Citrulline L-arginine Arugula, dill, beets, spinach, cabbage Supplements Tribulus Terrestris Fenugreek Tongkat Ali Give it 90 days to build in body. Bioidentical hormone replacement therapy Some hormones actually help you with things like hearing, like aldosterone. DHEA is a precursor to testosterone and estrogen. Typically, men feel good in the 700-1000 mg/dl. For women Combination of estrogen, bioidentical estrogen, as well as progesterone. Testosterone in coconut cream (used intravaginally) Herb Cycling Over time, your body actually adjusts to having herbal formulas, and then, they’re not as effective. Each month use a different herb to see what works for you best. Engorgement It means being filled with blood. It means to nest. When we’re born, when we’re in utero, we all start out as female. And about 16 weeks in, we get a, depending on the XY chromosome, we get a hormonal bath that turns half of us into boys. But we start out with exactly the same genital material. And that genital material turns into a penis or a vulva, a penis and scrotum or a vulva. The two channels that run down the penis, the corpus cavernosum and the corpus spongiosum, those are erectile tissue. Those are the chambers that fill up with blood to give a man an erection. Those chambers are in our clitoris. So, we have a clitoral head, a clitoral shaft, so we actually have a shaft, the glans is like the tip of the penis, the shaft is like the shaft of the penis. So, a woman actually achieves a clitoral erection given enough massaging or oral pleasuring, or lovemaking. And then, the clitoris has two little arms that drape over the entrance to the vagina. That’s called the introitus, the entrance to the vagina. And then it has two plump bags that are the legs of the clitoris, that are called the vestibular bulbs, that are actually under the pubic hair on each side of the opening to the vagina. And that whole structure is the erectile tissue of her clitoral structure that needs to get filled with blood. Then she has a urethral sponge. We have an extruded little tube that goes down the urethral outlet, where your urine comes from your bladder and exits out of your vulva, between your clitoris and the opening to your vagina. That’s an exit. There’s a tube that runs, a fluffy tube of erectile tissue there. That’s what people call the G-spot. You can get to it from the outside, and you can get to it from the inside of the vaginal canal. And then there’s another sponge, called the perineal sponge, that’s located between the rectum and the vagina, those two tubes are parallel up inside her, and there’s a spongy tissue between them. All of that’s erectile tissue. You only see half of a man’s shaft. There’s 50 percent of his penile tissue that’s buried up inside him. Sanskrit - Yoni is the woman’s vulva, and the Lingam is the man’s penis Yoni massage Use Sexual Soulmate Pact Lingam massage Performance Anxiety Once you understand anatomy and you start to really pleasure each other manually and orally, which gives you additional benefits, then it takes the focus off of intercourse, but it actually also makes intercourse even more pleasurable. Polarity Testosterone and estrogen Masculine and feminine Estrogen is femininity, it’s all over the map, it’s going a million miles, it’s got its eyes on everything, it’s sensitive, it’s delicate, it’s fussy. Testosterone is straight ahead, goal-oriented, able to just be like in the zone much more easily. Communication and Getting Your Needs Met Passionate lovemaking is emotionally-connected lovemaking. It’s when you feel totally safe with each other, when you can surrender to your pleasure together, when you can just lock your systems together and go off into joy, that you don’t know where their pleasure starts and your pleasure ends. For a woman especially, to be able to let go, she needs the conditions to be right outside the bedroom as well as inside the bedroom. Women want to be totally taken care of, but they also want some freedom. Women today are very emancipated. Men don’t understand how much romance is important to women, how much encouraging her, telling her you love her, taking her out for a walk in the countryside, rowing her in a boat on the lake, taking her for a hike. Moving a woman’s body moves her emotions, and she wants to feel an emotional connection to you. Men, often, what they want is recreational companionship. They want touch, affection, passion. Physical touch for them is love. The Platinum Rule Treat your partner the way they want to be treated. Behind Closed Doors With 20 percent of the effort, you get 80 percent of the results. Sexual Soulmates book You put intention on being a soulmate and learning how to do it. Six Essentials for Connected Sex The Sexual Soulmate Pact Lover’s Space Creating a sacred place for you to make love with each other, for slowing down, for getting the temperature right, the sheets soft, having plenty of towels, having organic lube, a pitcher of water, lighting the candles, putting on the music that appeals to you and gets you in the mood, wearing sexy lingerie, dancing for your partner, doing all the kinds of things that are just like getting back into play and making the environment really, really nice. The Soulmate Embrace Embodied Sex You’re feeling her, you’re touching her skin, you’re not even stroking her skin, you’re touching below her skin to the tissue underneath the skin to give pleasure, you’re bringing pleasure to yourself in all these wonderful nerve receptors by touching her for your own pleasure. You’re stroking each other’s whole bodies, you’re not just using friction of genitals, which is kind of like unconscious sex. This is conscious sex. Presence Presence in lovemaking is a mindset. It is just like meditation, where when you meditate, and then you start thinking about something else, and then you bring yourself back. If you’re worrying about having an orgasm, you’re not going to have one. Feeling Your Pleasure Letting go Sympathetic/parasympathetic nervous system toggling Orgasms actually come out of you. They bubble up out of you like a spring bubbles up out of the ground. Polarity Masculine/feminine Reengage with the Soulmate Embrace Create a safe container for her to let go. Body shame, women as well as men. Atrophy sets in when you don’t make love Erotic Playdates The more that you turn bedroom into play, the happier you are, and when you learn new things together, the beginner’s mind of meditation, that is really, really great. You can learn about female ejaculation. Men can learn male multiple orgasm. You can learn to have expanded orgasms. Finding Time for Sex An hour is a quickie. It takes 20-30 minutes for your genitals to get engorged. You have to schedule it. You have to get a babysitter; you have to get the kids to bed early and get dinner done and make a commitment to it. Set a timer if you have to go somewhere so that you can come down from the oxytocin rush. Don’t make the goal about sex. Deeper Dive Resources Organixx Supplements https://shop.organixx.com/search?q=sexual+health Organixx Articles on Libido https://organixx.com/?s=libido The Soulmate Embrace https://personallifemedia.com/soulmate-embrace/ The Sexual Soulmate Pact https://personallifemedia.com/sexual-soulmate-pact/ Susan’s Instagram https://www.instagram.com/susanbratton/ Susan’s YouTube https://www.youtube.com/c/BetterLover Sexual Soulmates Book https://amzn.to/2X8nHMd My Relationship Magic https://best.personallifemedia.com/relationship-magic-promo/?email_address= Maca https://en.wikipedia.org/wiki/Lepidium_meyenii Cacao https://en.wikipedia.org/wiki/Theobroma_cacao Citrulline https://en.wikipedia.org/wiki/Citrulline L-Arginine https://en.wikipedia.org/wiki/Arginine Tribulus Terrestris https://en.wikipedia.org/wiki/Tribulus_terrestris
Susan Bratton, the Dear Abby of sex, joins us again with six essentials for connected sex. Tune in to understand herb cycling and supplementation to support our sexual health against health issues that impact our sexuality, especially as we age. Susan also helps us be better communicators in and out of the bedroom. Something we can all use! * * * About Susan Susan is a champion and advocate for all who desire passionate relationships. Considered the Dear Abby of sex, Susan’s fresh approach and original ideas have helped millions of people of all ages and across the gender spectrum transform sex into passion. Married to her husband, Tim, since 1993, Susan is an author, award-winning speaker, and serial entrepreneur, who teaches passionate lovemaking techniques to her fans around the world. Susan has been featured in the New York Times and on CNBC and The Today Show, as well as appearing on ABC, CBS, The CW, Fox, and on NBC as the Marriage Magician. Susan is the Chair Emeritus of The AdTech Conference. She was both CMO and a member of the board of directors for an Anthony Robbins tech startup, as well as serving on numerous boards throughout her career. In 2009, Susan was honored as a Silicon Valley Woman of Influence by the Business Journal, and as a top 10 internet pioneer by Ad Age Magazine. In 2010, was bestowed the Lifetime Industry Achievement Award by DMG World Media. Susan talks about, after 25 years of marriage, “I know from experience that deep passionate intimacy with my partner is priceless, a priority that tops my list of must-haves, alongside good health and the love of family and friends. I have made it my mission to aide anyone who wants the kind of lovemaking that improves with age.” * * * Your Libido Is Your… Sex drive Creativity Passion Lust for live Vitality What Health Issues Impact Your Sexuality? Diabetes/Pre-Diabetes Neuropathy Loss of sensation Anorgasmia Heart disease Plaque in your arteries/veins Not enough blood flow to your penis Supplementation It took you this long to get sick, you’re not going to get healthy in a matter of days. We’re always working on our health because we’re always trying to reverse anti-aging, we’re trying to do anti-aging, we’re trying to reverse atrophy. Everything external is a reflection of internal, including our genitalia. Adaptogens/plant-based botanicals Support hormones Lower cortisol Increase testosterone Increase estrogen Manage aromatase expression of over-estrogen in men Supporting herbs Maca – libido support Cacao – polyphenols Nitric oxide precursors Citrulline L-arginine Arugula, dill, beets, spinach, cabbage Supplements Tribulus Terrestris Fenugreek Tongkat Ali Give it 90 days to build in body. Bioidentical hormone replacement therapy Some hormones actually help you with things like hearing, like aldosterone. DHEA is a precursor to testosterone and estrogen. Typically, men feel good in the 700-1000 mg/dl. For women Combination of estrogen, bioidentical estrogen, as well as progesterone. Testosterone in coconut cream (used intravaginally) Herb Cycling Over time, your body actually adjusts to having herbal formulas, and then, they’re not as effective. Each month use a different herb to see what works for you best. Engorgement It means being filled with blood. It means to nest. When we’re born, when we’re in utero, we all start out as female. And about 16 weeks in, we get a, depending on the XY chromosome, we get a hormonal bath that turns half of us into boys. But we start out with exactly the same genital material. And that genital material turns into a penis or a vulva, a penis and scrotum or a vulva. The two channels that run down the penis, the corpus cavernosum and the corpus spongiosum, those are erectile tissue. Those are the chambers that fill up with blood to give a man an erection. Those chambers are in our clitoris. So, we have a clitoral head, a clitoral shaft, so we actually have a shaft, the glans is like the tip of the penis, the shaft is like the shaft of the penis. So, a woman actually achieves a clitoral erection given enough massaging or oral pleasuring, or lovemaking. And then, the clitoris has two little arms that drape over the entrance to the vagina. That’s called the introitus, the entrance to the vagina. And then it has two plump bags that are the legs of the clitoris, that are called the vestibular bulbs, that are actually under the pubic hair on each side of the opening to the vagina. And that whole structure is the erectile tissue of her clitoral structure that needs to get filled with blood. Then she has a urethral sponge. We have an extruded little tube that goes down the urethral outlet, where your urine comes from your bladder and exits out of your vulva, between your clitoris and the opening to your vagina. That’s an exit. There’s a tube that runs, a fluffy tube of erectile tissue there. That’s what people call the G-spot. You can get to it from the outside, and you can get to it from the inside of the vaginal canal. And then there’s another sponge, called the perineal sponge, that’s located between the rectum and the vagina, those two tubes are parallel up inside her, and there’s a spongy tissue between them. All of that’s erectile tissue. You only see half of a man’s shaft. There’s 50 percent of his penile tissue that’s buried up inside him. Sanskrit - Yoni is the woman’s vulva, and the Lingam is the man’s penis Yoni massage Use Sexual Soulmate Pact Lingam massage Performance Anxiety Once you understand anatomy and you start to really pleasure each other manually and orally, which gives you additional benefits, then it takes the focus off of intercourse, but it actually also makes intercourse even more pleasurable. Polarity Testosterone and estrogen Masculine and feminine Estrogen is femininity, it’s all over the map, it’s going a million miles, it’s got its eyes on everything, it’s sensitive, it’s delicate, it’s fussy. Testosterone is straight ahead, goal-oriented, able to just be like in the zone much more easily. Communication and Getting Your Needs Met Passionate lovemaking is emotionally-connected lovemaking. It’s when you feel totally safe with each other, when you can surrender to your pleasure together, when you can just lock your systems together and go off into joy, that you don’t know where their pleasure starts and your pleasure ends. For a woman especially, to be able to let go, she needs the conditions to be right outside the bedroom as well as inside the bedroom. Women want to be totally taken care of, but they also want some freedom. Women today are very emancipated. Men don’t understand how much romance is important to women, how much encouraging her, telling her you love her, taking her out for a walk in the countryside, rowing her in a boat on the lake, taking her for a hike. Moving a woman’s body moves her emotions, and she wants to feel an emotional connection to you. Men, often, what they want is recreational companionship. They want touch, affection, passion. Physical touch for them is love. The Platinum Rule Treat your partner the way they want to be treated. Behind Closed Doors With 20 percent of the effort, you get 80 percent of the results. Sexual Soulmates book You put intention on being a soulmate and learning how to do it. Six Essentials for Connected Sex The Sexual Soulmate Pact Lover’s Space Creating a sacred place for you to make love with each other, for slowing down, for getting the temperature right, the sheets soft, having plenty of towels, having organic lube, a pitcher of water, lighting the candles, putting on the music that appeals to you and gets you in the mood, wearing sexy lingerie, dancing for your partner, doing all the kinds of things that are just like getting back into play and making the environment really, really nice. The Soulmate Embrace Embodied Sex You’re feeling her, you’re touching her skin, you’re not even stroking her skin, you’re touching below her skin to the tissue underneath the skin to give pleasure, you’re bringing pleasure to yourself in all these wonderful nerve receptors by touching her for your own pleasure. You’re stroking each other’s whole bodies, you’re not just using friction of genitals, which is kind of like unconscious sex. This is conscious sex. Presence Presence in lovemaking is a mindset. It is just like meditation, where when you meditate, and then you start thinking about something else, and then you bring yourself back. If you’re worrying about having an orgasm, you’re not going to have one. Feeling Your Pleasure Letting go Sympathetic/parasympathetic nervous system toggling Orgasms actually come out of you. They bubble up out of you like a spring bubbles up out of the ground. Polarity Masculine/feminine Reengage with the Soulmate Embrace Create a safe container for her to let go. Body shame, women as well as men. Atrophy sets in when you don’t make love Erotic Playdates The more that you turn bedroom into play, the happier you are, and when you learn new things together, the beginner’s mind of meditation, that is really, really great. You can learn about female ejaculation. Men can learn male multiple orgasm. You can learn to have expanded orgasms. Finding Time for Sex An hour is a quickie. It takes 20-30 minutes for your genitals to get engorged. You have to schedule it. You have to get a babysitter; you have to get the kids to bed early and get dinner done and make a commitment to it. Set a timer if you have to go somewhere so that you can come down from the oxytocin rush. Don’t make the goal about sex. Deeper Dive Resources Organixx Supplements https://shop.organixx.com/search?q=sexual+health Organixx Articles on Libido https://organixx.com/?s=libido The Soulmate Embrace https://personallifemedia.com/soulmate-embrace/ The Sexual Soulmate Pact https://personallifemedia.com/sexual-soulmate-pact/ Susan’s Instagram https://www.instagram.com/susanbratton/ Susan’s YouTube https://www.youtube.com/c/BetterLover Sexual Soulmates Book https://amzn.to/2X8nHMd My Relationship Magic https://best.personallifemedia.com/relationship-magic-promo/?email_address= Maca https://en.wikipedia.org/wiki/Lepidium_meyenii Cacao https://en.wikipedia.org/wiki/Theobroma_cacao Citrulline https://en.wikipedia.org/wiki/Citrulline L-Arginine https://en.wikipedia.org/wiki/Arginine Tribulus Terrestris https://en.wikipedia.org/wiki/Tribulus_terrestris
Subscribe To Bulldog Mindset YouTube Channel: https://bulldogmindset.com/bulldog-yt-podcast Are You A Bulldog? TAKE THE QUIZ: https://bulldogmindset.com/bulldog-quiz-podcast What are the best supplements if you're eating one meal a day (OMAD)? #supplements #omad #onemealaday I take lots of supplements because, overall, people who do OMAD have kind of an electrolytic disadvantage, especially when it comes to sodium, potassium, and magnesium. However, I do also take other supplements which I believe are great for building muscle and losing fat while doing OMAD. 00:53 Magnesium 01:54 Multivitamins 02:00 Zync 02:08 Vitamin D3 02:22 Creatine 02:24 L-Arginine 02:27 Turmeric 03:39 Yohimbine HCl 05:44 BCAA (Don't take if you're doing OMAD) 05:52 HMB What supplements do you take while doing OMAD? Leave a comment below and let me know. OMAD - One Meal A Day (Transformation & Tips): https://www.youtube.com/watch?v=uaL8G2v-1dU&list=PLjwWT1Xy3c4VIgaemPJrH3NcEjcfoydBW Amazon Influencer Page: https://bulldogmindset.com/amazon
Jim Goetz Dr. Mike Brandon Chantea Goetz The big announcement is that our BiohackHumans website now has an Insiders Only Section. Be the first to see world class workout programs, high quality recipes, videos, how Dr. Mike Brandon lost 30 lbs in 5 days step by step and m uch much more!!!! New Theories Behind The Real Cause of Lymes Disease and Possible Natural Treatments Jim Goetz Since the 1970's in the town of Lymes, Connecticut, individuals have been coming down with a mysterious illness diagnosed as many things. The symptoms are pretty much the same. They include: fatigue, muscle pain, weakness, twitching, spasms, restless leg syndrome, mental fog, joint pain, swelling, and tingling in the extremities. (These symptoms sounds seriously like every night after my three times per day workouts). Because of the grouping of symptoms, health officials believed they needed to find the cause of this new "disease". A few years later, an individual who had these symptoms stated they reported having a tick on them a few weeks prior to the symptoms occurring. Researchers found this specific type of tick to carry the bacteria Borrelia burgdorferi and "hallejuia" an answer was found (though it was based on mere observation). Lymes has traditionally been treated by using a very large dose full spectrum anti-biotic. Patients often get better at first giving doctors the impression that the drugs are working. This is called a Herxheimer reaction. That is symptoms reverse. Now with this dose of antibiotics, your body is also losing beneficial bacteria that your body needs to function and yes, even think. Unfortunately antibiotics at times casue viruses to strengthen. In this case, this is true. Recently there has been some speculation that Lymes disease is also caused by other bacteria such as Bartonella or parasites such as Babesia. None of these however or Borrelia actually seem to be responsible for the actual symptoms of Lymes disease. Someone may test positive for one of these bacteria or parasites and have Lymes disease but this again may only be another observational study and the two may have nothing to do with another. This is like someone observing an individual with a cold having eaten a pizza just the day prior and no other foods. Therefore colds must be caused by pizza. This simply is not the truth. The symptoms of Lymes disease are the same as those who have Epstein-Barr, HHV-6 and it's varous strains. Some also test positive for cytomegalo virus. These are all viruses!!! Exactly!!!!! Lymes disease may actually be a virus that most of us have that is actually triggered by events in life. All of these items in some way or another lower ones immune response. As a result, a dormant virus can take over. These possible causes include (but not limited to: -mold -mercury based dental mamlgam fillings -mercury in general -emotional events such as the loss of a loved one or traumatic event -bites or stings -virus enabling prescripton medications (see benzodiazepines) -overprescribed medications -recreational drug abuse -overly stressful chronic situations such as finances -lack of sleep -poor nutrition -chemicals in ones environment such as carpets or carpet cleaning products, paint, etc. -runoff -swimming (chlorine is highly toxic in pools as are red algae blooms in the ocean) Some natural treatments include but are not limited to: -thyme (kills viruses on contact). I often use this in a diffuser and breathe it in the room, especially in fall and winter. I have no proof it works but know I do not get sick often. -lemon balm (kills co-factors of viruses). It's also naturally soothing and used in many good bed time/ relaxation formuals. -zinc (lowers inflammation and may raise immune levels) If you put a zinc losenger in your mouth though and it tastes highly metallic, your zinc levels may already be normal and therefore risk toxicity. -licorice root (impairs viral movement and ability to reproduce) -L-lysine (same as licorice root). However, L-lysine is used during herpes outbreaks as it appears to be directly inverse to L-Arginine, a vasodialator. L- Arginine and foods containing this amino acid are to be avoided during times of outbreaks. -Lomatium root (removes pathogens from the body). -reishi mushrooms (increases lymphocytes, and neutrophils, which are white blood cells responsible for immune function). -silver hydrosol (kills viruses on contact) -astaxanthin (restores neurological function) This is found in krill supplements and Green Vibrance. Both area a staple in the diet of the madscientist himself. -nascent iodine (strengthens the encocrine system) Swing Away Depression and Anxiety Dr. Mike Brandon Jumping on a trampoline, swinging in the park, running in circles, and rolling down hills may sound like a day's summer schedule for a child, but what about as a way to help combat depression, anxiety, and memory deficits in us all. Our body's vestibular system is what helps us with our balance and equilibrium and allows us to do things like walking and standing upright, standing on one leg, walk across a tight rope etc. The majority of this system is small structures buried within our ears which works with our eyes and specific regions of our brain. It gets strengthened via body and head movements like rolling, jumping, spinning, and so forth. We rarely think about it unless there's an issue like becoming dizzy or losing balance, but clearly this system is important for us. Could you imagine trying to go through a day without being able to walk 10 feet without falling to the side? Science has found however that having a healthy balancing system may also help with stress, anxiety and depression. It appears that having vestibular dysfunction, like dizziness or vertigo, can cause increased anxiety and stress, and even the reverse with having excess stress or anxiety disorders could cause dizziness or vertigo. So clearly they are related, but why does that matter? There was a study that took college students and gave them “swing time” every day, meaning they literally went to a park, sat on a swing and swung back and forth for a while. This caused all participants to have a positive change on their emotional state with depression, stress, and anxiety. This led me to think about children and the importance of recess. Its been over the news the past few years when it was shown that increased play time increased academic performance. This could be a big part as to why. Children's brains are still developing, so having kids “just be kids” and run, roll, and jump, is quite important so they have a better chance at staying happy and coping with the stress that inevitably arises in life. Currently, kids don't play as much as they used to due to tv, video games, and similar activities, so their vestibular system which is linked to strong emotional control and satisfaction may not get fully developed. Add to that then how most of us as adults live rather sedentary lives and sit most of the day, so we aren't strengthening our equilibrium and balance systems either. The good news is, that it appears that even as adults we can help ourselves by “just being a kid”. So maybe I wouldn't advice grandpa to go hop on a merry-go-round or start doing flips on the trampoline, but gently rocking in a chair or standing on a wobble board for a while may help his occasional panic attacks or make him smile a bit more. It shouldn't be surprising then that most people enjoy things such as swinging and spinning. Everybody wants to stay young, and though we have yet to biohack a secret for that, there's clearly benefits by following a child's example in this case. So go make yourself a little dizzy, a little happy, and as always, BioHack on! References: Dalton, S. (2016, May 11). Youth Fitness: Exercise Helps Children Excel in School. Retrieved June 16, 2017, from http://www.healthline.com/health/youth-fitness-exercise-helps-children-excel-school#5 Eisenbarth, C. A. (2013). Influence of Optimism on Appraised Stress, Depression, and Anxiety Among College Students. Journal of Psychology Research, 3(6), 295-297. doi:10.17265/2159-5542/2013.06.003 Gurvich C., Maller J. J., Lithgow B., Haghgooie S., Kulkarni J. (2013, in press). Vestibular insights into cognition and psychiatry. Brain Res. [Epub ahead of print]. 10.1016/j.brainres.2013.08.058 Halberstadt A. L., Balaban C. D. (2006). Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus. Neuroscience 140, 1067–1077 10.1016/j.neuroscience.2006.02.053 Mukkadan, J., Rajagopalan, A., Jinu, K., Sailesh, K., Mishra, S., & Reddy, U. (2017). Understanding the links between vestibular and limbic systems regulating emotions. Journal of Natural Science, Biology and Medicine, 8(1), 11. doi:10.4103/0976-9668.198350 Smith, P. F., & Darlington, C. L. (2013). Personality changes in patients with vestibular dysfunction. Frontiers in Human Neuroscience, 7. doi:10.3389/fnhum.2013.00678 biohackhumans.com Find us: Instagram (@biohackhumans) Facebook (@biohackhumans) Twitter (@biohackhumans) Tumblr (@biohackhumans) Contact Us: support@biohackhumans.com
Are you looking to improve your fitness levels? Or seek relief from IBS? Maybe even increase your Libido or sexual stamina? Joins us today as we share our experiences about the new wonder supplement and find out what is all the fuss about L Arginine? The post Whats all the fuss about L Arginine appeared first on Balanced Wellness - The Alternative Health Experts.
http://fitmenover40.com In this episode you will learn: - Why most pre-workout supplements are overpriced hype - How a pre-workout supplement can benefit your training - What ingredients make up an effective pre-workout supplement - The correct dosages to get the most bang for your buck Resources mentioned in this episode: L-Arginine - http://goo.gl/ovsYhf L-Citrulline - http://goo.gl/WnQLUt L-Tyrosine - http://goo.gl/qeGUrb Acetyl-L-Carnitine - http://goo.gl/50XBQs Caffeine - http://goo.gl/IRUkbn Beta-Alanine - http://goo.gl/q86lEA
EZ Wellness, News and Reviews of the Hottest Health Supplements
Introductions to l-arginine, Raspberry Ketone, Green Coffee Bean and Ignite Maxx. http://ezwellnessclub.com/
Click to Subscribe to All Ben's Fitness & Get A Free Surprise Gift from Ben. Click here for the full written transcript of this podcast episode In this February 24th free audio episode: The Latest Research from The Journal of Strength & Conditioning, Double Chins, Heart Rate Monitors, Testosterone, Soreness, Pre-Race Jitters and Protein! Remember, if you have any trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com.And don't forget to leave the podcast a ranking in iTunes - it only takes 2 minutes of your time and helps grow our healthy community! Just click here to go to our iTunes pageand leave feedback. ---------------------------------------- Special Announcements 1. As the creator of the 300 page guide to fat loss, entitled "Fat Loss Lifestyle Manual", the designer of the entire "Cardio Intervals DVD Series" and your personal guide in his brand new "Fat Loss Lifestyle Exercise Video Library",personal trainer Darin Steen agreed to be interviewed by me and reveal some of his top fat loss tricks and tips, including some of the very same techniques he uses as personal fitness adviser to Dr. Mercola. You should definitely check out our fat loss interview by clicking here. 2.The 2010 Ironman CDA Triathlon Camp is being taught by Ben Greenfield from Sunday, May 16- Wednesday May 19, 2010, and is specifically designed to completely prepare you for the race course, race day tactics and nutrition and pacing strategies for Ironman Coeur D' Alene! Click here for more information and to register. 3. Ready to re-invent your body and discover how to eat and exercise in the most effective way possible? Ben's Body Transformation Club is now open and accepting 50 new members for March of 2010. What the heck is Ben's Body Transformation Club? You'll need to click here to find out! ---------------------------------------- Listener Q&A Listener Troy asks: Hey Ben, I have a question about spot reduction. I know people always say that it is a myth. However, I used to be a triathlete, and I was very lean. My workouts consisted of lots of intense workouts. I switched my focus to marathon running. I still do some intense training, but obviously I focus much more on mileage and longer slower workouts. Anyways, as I have switched to my marathon training, I have realized that my face is fatter. I am just as lean as I was when I was triathlon training. I have low body fat and you can see my abs but I have more face fat than I ever have. I sortof have a double chin and I am very self conscious about it. It doesnt make sense that someone who is marathon training has this problem. I see people who rarely workout who don't have nearly the fat around their neck/face as I do. I understand that it is probably genetic, but is it possible that the type of training that I am doing affects my fat distribution? If the answer is yes, doesnt this negate the idea that spot reduction is a myth? Finally, is there any way to reduce the fat around my face. I already have very low body fat, and any more fat reduction would require a great deal of sacrifice and supplements. I was wondering if there are any particular exercise I can do that will target this area. Would adding more intense workouts help? Listener Kevin asks: You recently aired an episode about your testosterone levels. You mentioned that yours was 46 and you increased it to the lower 70s with supplementation. Questions: (1) I had blood work done last month and mine was 345. My doctor advised that the range is between 200 and 750. I certainly want to be on the higher end of the range. I supplement my 2100 - 2500 calorie diet (30% Fat, 33% Carb and 36% Protein) with a multi, vitamin D, BCAA, L-Arginine, Fish Oil, Flax Oil and Flax Mill. I also consume whey isolate and casein. I'm in the gym daily - doing cardio 30 to 60 minutes (LISS and HIIT) and weight lighting 5-6 days a week. My Polar monitor records 700 to 1000 calories per workout - typically at 55% body fat burned. I'm 50 years old, 5'11", 195 lbs and 18% body fat. My goal is increase my lean body mass by decreasing my body fat by 5 points. Do you have any ideas on how I can increase my test level? (2) Why do I have a 345 number and you a 46? My exam was via blood and yours saliva but I would think we'd still use the same testosterone scale. No? Listener Lorenzo asks: Can you get low testosterone from being hit in the head (too many concussions)…my doc said that it is a possibility and that it can disrupt your pituitary gland. If the answer is yes, what can you do about correcting it? Listener Elsa asks: I started my strength training a few days ago (squats, push ups, crunches) but it really made my muscle sore and it takes me a few days to recover. Is it that my workout is too intense and too long? Or is that normal? Do all lean people feel a bit sore in their muscles all the time? Thanks! Listener Wendy asks: My husband is downhill ski racing in a week or so and he is working with some pre-race jitters already. He has worked and trained so hard and i am would love to see him have some tools to deal with all the junk that gets in your head! Do you have any suggestions for pre-race poopiness! Thanks Ben. Listener Sondra asks: I am fairly new to your podcast and love the information that you have made available. I am also a member of your Body Transformation Club and look forward to what you have in store starting in March. I have started taking MSM (1000 mg capsules once a day in the morning with breakfast) a little over two weeks ago. This week I have noticed a splotchy rash that seems to be getting progressively worse. I first noticed it on my arm but now it is pretty much everywhere. Is this a common reaction to MSM that will subside or should I discontinue it? Listener Patrick has a call in question about heart rate monitors and how to improve accuracy, as well as a question about whether to take a supplement like MAP if he's still eating protein from real food on a refeeding day. Listener Richard asks: Thanks again for the fantastic Podcasts and resources! Just two quick questions: 1) Do you see any benefits of Hemp Protein over Whey Protein (or vica versa) – I have recently switched to Hemp and find I get far less bloating. 2) Do you think it is possible to ‘overdose' or stress your liver and kidneys with too much protein. I tend to use protein only after exercise (25 grams) and a little (25 grams) in my breakfast porridge as it keeps me satiated for longer. As long as I drink plenty of water, how much is too much? Best wishes and keep up the great work. Finally, listener Eddy wants to run marathon 9 weeks before an Ironman. Will it negatively affect his Ironman? 1-920-428-5644. He also has a question about "The Marathon Dominator." --------------------------------------- Remember, if you have any trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com.And don't forget to leave the podcast a ranking in iTunes - it only takes 2 minutes of your time and helps grow our healthy community! Just click here to go to our iTunes page and leave feedback. [embed]http://www.bengreenfieldfitness.com/BenGreenfieldFitness83.mp3[/embed]
Unfortunately during our last show we ran out of time so this show will be a continuation of Heart Healthy Vitamins and Supplements. During this episode we will discuss more vitamins and supplements and their heart health claims based on the most current research. This 30 minute show will cover: soy, vitamin D, Coenzyme Q10, Policosanol, Guggul, L-Arginine and Lycopene.
Unfortunately during our last show we ran out of time so this show will be a continuation of Heart Healthy Vitamins and Supplements. During this episode we will discuss more vitamins and supplements and their heart health claims based on the most current research. This 30 minute show will cover: soy, vitamin D, Coenzyme Q10, Policosanol, Guggul, L-Arginine and Lycopene.
Objective: To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage. Background. Depressed wound immune function contributes to an increased incidence of wound infections following hemorrhage. Although administration of L-arginine has been shown to restore depressed cell-mediated immune responses following hemorrhage potentially by maintaining organ blood flow, it remains unknown whether Larginine has any salutary effects on the depressed local immune response at the wound site. Methods: Male mice were subjected to a midline laparotomy and polyvinyl sponges were implanted subcutaneously in the abdominal wound prior to hemorrhage (35 +/- 5 mm Hg for 90 min and resuscitation) or sham operation. During resuscitation mice received 300 mg/kg body weight L-arginine or saline (vehicle). Sponges were harvested 24 h thereafter, wound fluid collected and wound immune cells cultured for 24 h in the presence of LPS. Pro- (IL-1beta, IL-6) and anti-inflammatory (IL-10) cytokines were determined in the supernatants and the wound fluid. In addition, wounds were stained for IL-6 immunohistochemically. In a separate set of animals, skin and muscle blood flow was determined by microspheres. Results: The capacity of wound immune cells to release IL-1beta and IL-6 in vitro was significantly depressed in hemorrhaged mice receiving vehicle. Administration of L-arginine, however, improved wound immune cell function. In contrast, in vivo the increased IL-6 release at the wound site was decreased in L-arginine-treated mice following hemorrhage. Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice. In addition, the depressed skin and muscle blood flow after hemorrhage was restored by L-arginine. Conclusions: Thus, L-arginine might improve local wound cell function by decreasing the inflammatory response at the wound site. Since L-arginine protected wound immune cell function this amino acid might represent a novel and useful adjunct to fluid resuscitation for decreasing wound complications following hemorrhage. Copyright beta 2002 S. Karger AG, Basel.
Tue, 1 Jan 1991 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9509/1/9509.pdf Anderson, J. M.; Jonas, Udo; Stief, Christian Georg; Holmquist, F.
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