Podcasts about Derivation

The Critical Importance of Intellectual Property Protection for Businesses and InnovatorsIn a recent episode of "The Thoughtful Entrepreneur," host Josh engages in a compelling discussion with Daniel Scola, the managing partner of Hoffman & Baron LLP, a law firm specializing in intellectual property (IP) protection. The conversation centers around the critical importance of safeguarding intellectual property for businesses and innovators. This blog post will break down the key insights and actionable advice shared during the episode, providing a comprehensive guide for listeners and readers alike.Josh opens the episode by inviting listeners who are seeking connections with partners, investors, influencers, and clients to explore his services. He shares his extensive experience, having had private conversations with over 2,000 leaders to understand where their best business opportunities arise. Josh offers a free video resource that outlines steps to achieve 100% inbound marketing in one's industry over the next six to eight months, emphasizing a spam-free, ad-free, and sales-free approach. He encourages listeners to visit his website, Up My Influence, to access this valuable content. After the introduction, Josh welcomes Daniel Scola to the podcast. Daniel is introduced as the managing partner of Hoffman and Baron LLP, and listeners are directed to the firm's website for more information. Daniel expresses his gratitude for the opportunity to join the conversation.Daniel explains that his firm focuses on protecting clients' ideas through various forms of IP, including patents, trademarks, and copyrights. He emphasizes that ideas are foundational to society and business, serving as the driving force behind innovation and economic growth. Daniel highlights that many businesses overlook the significance of IP, which can create competitive advantages and barriers to entry in the market. He shares success stories, such as a group of doctors who developed a groundbreaking medical device for treating atrial fibrillation (AFib) and secured hundreds of patents, ultimately selling their IP to a major company for over $250 million. Daniel also outlines the key steps in securing a patent and stresses the importance of confidentiality agreements when discussing ideas with potential partners or investors.About Daniel Scola:Daniel Scola is a seasoned intellectual property professional with particular expertise in developing, procuring, and defending IP estates across patents, trademarks, and copyrights. He has extensive experience representing clients before courts and various Patent Offices worldwide. Daniel specializes in post-grant proceedings, including Inter Partes Review (IPR), Derivation, and Post Grant Review (PGR) cases.His practice encompasses a wide range of opinion work, including freedom-to-operate assessments, patentability evaluations, validity determinations, and non-infringement analyses. Daniel also conducts thorough IP due diligence investigations and negotiates technology agreements, IP licensing agreements, and entertainment contracts. With in-depth knowledge of foreign patent and trademark oppositions, he has a proven track record in EPO Oppositions and Appeals, positioning him as a valuable asset in the field of intellectual property law.About Hoffman & Baron, LLP:A full-service law practice specializing in all areas of intellectual property, both domestically and internationally. They prioritize quality without compromise, providing a cost-effective approach to achieve the most favorable outcomes for their clients. Guided by principles of commercial success, efficiency, and discipline, they navigate the complexities of IP law.Founded in 1984 by co-founders and partners Charles R. Hoffmann and Ronald J. Baron, the firm has established offices in New York, New Jersey, and Washington D.C. It...

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Stuart Goldstein, MD is a Professor of Pediatrics at the University of Cincinnati, where he serves as the Clark D. West Endowed Chair. He is a practicing pediatric nephrologist at Cincinnati Children's where he also is the Director for the Center for Acute Care Nephrology and the Medical Director for the Pheresis Service. Dr Goldstein is the Founder and Principal Investigator for the Prospective Pediatric Acute Kidney Injury Research Group and has evaluated novel urinary AKI biomarkers in the pediatric critical care setting. Dr. Katherine Melink (at time of recording) is currently finishing her residency at Cincinnati Children's Hospital where she was able to conduct research in biomarkers for the prediction of kidney injury in critically ill children (particularly in the CICU). Her exposure to CRRT under physicians like Dr. Goldstein at Cincinnati Children's has served as a motivating factor to participate in this episode! She is excited to start PICU fellowship at Boston Children's Hospital in July.Learning Objectives:By the end of this podcast, listeners should be able to discuss:CRRT fundamentals, including how it differs from conventional hemodialysis and the rationale for its use in critically ill pediatric patients.Key differences in ultrafiltration, diffusion, and convection and their clinical applications in CRRT.Patient selection and indications for CRRT (AKI, fluid overload, toxic metabolite/ingestion among others)Key evidence guiding use of CRRT in critically ill children.Components of a CRRT prescription and guiding principles of how to titrate therapy.Pitfalls and complications of CRRTCommon anticoagulation strategies in CRRTGeneral principles guiding liberation from CRRT.Selected references:Sutherland et al; ADQI 26 Workgroup. Epidemiology of acute kidney injury in children Pediatr Nephrol. 2024 Mar;39(3):919-928. doi: 10.1007/s00467-023-06164-w. Epub 2023 Oct 24. Basu et al. Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int. 2014 Mar;85(3):659-67. doi: 10.1038/ki.2013.349. Epub 2013 Sep 18. PMID: 24048379; Fuhrman et al; ADQI 26 workgroup. A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children. Pediatr Nephrol. 2024 Mar;39(3):929-939. doi: 10.1007/s00467-023-06133-3. Epub Questions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

Stuart Goldstein, MD is a Professor of Pediatrics at the University of Cincinnati, where he serves as the Clark D. West Endowed Chair. He is a practicing pediatric nephrologist at Cincinnati Children's where he also is the Director for the Center for Acute Care Nephrology and the Medical Director for the Pheresis Service. Dr Goldstein is the Founder and Principal Investigator for the Prospective Pediatric Acute Kidney Injury Research Group and has evaluated novel urinary AKI biomarkers in the pediatric critical care setting. Dr. Katherine Melink (at time of recording) is currently finishing her residency at Cincinnati Children's Hospital where she was able to conduct research in biomarkers for the prediction of kidney injury in critically ill children (particularly in the CICU). Her exposure to CRRT under physicians like Dr. Goldstein at Cincinnati Children's has served as a motivating factor to participate in this episode! She is excited to start PICU fellowship at Boston Children's Hospital in July.Learning Objectives:By the end of this podcast, listeners should be able to discuss:CRRT fundamentals, including how it differs from conventional hemodialysis and the rationale for its use in critically ill pediatric patients.Key differences in ultrafiltration, diffusion, and convection and their clinical applications in CRRT.Patient selection and indications for CRRT (AKI, fluid overload, toxic metabolite/ingestion among others)Key evidence guiding use of CRRT in critically ill children.Components of a CRRT prescription and guiding principles of how to titrate therapy.Pitfalls and complications of CRRTCommon anticoagulation strategies in CRRTGeneral principles guiding liberation from CRRT.Selected references:Sutherland et al; ADQI 26 Workgroup. Epidemiology of acute kidney injury in children Pediatr Nephrol. 2024 Mar;39(3):919-928. doi: 10.1007/s00467-023-06164-w. Epub 2023 Oct 24. Basu et al. Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int. 2014 Mar;85(3):659-67. doi: 10.1038/ki.2013.349. Epub 2013 Sep 18. PMID: 24048379; Fuhrman et al; ADQI 26 workgroup. A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children. Pediatr Nephrol. 2024 Mar;39(3):929-939. doi: 10.1007/s00467-023-06133-3. EpubQuestions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the Show.How to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

Heute geht es einerseits um das Genus, das sprachliche Geschlecht, das aber natürlich eigentlich gar kein Geschlecht ist. Woher kommt es und warum und wozu haben wir es im Deutschen? Andererseits geht es um den Sexus, das außersprachliche, realweltliche Geschlecht einer Person oder eines Tieres (egal, ob biologisch, sozial, psychologisch oder juristisch). Vor allem aber geht es um den Zusammenhang zwischen Genus und Sexus: mit der grammatischen Kategorie Genus kann man nämlich ganz einfach das Geschlecht einer Person oder eines Tieres ausdrücken. Und wir lernen, dass selbst, wenn man zum "falschen" Genus greift, das etwas über das Geschlecht einer Person aussagen kann.Ein Podcast von Anton und Jakob. Instagram: https://www.instagram.com/sprachpfade ---Weiterführende Literatur: Greville G. Corbett (1991): Gender, Cambridge.Charles F. Hockett (1958): A course in Modern Linguistics, New York. (Zitat zur Definition von Genus auf S. 231).Klaus-Michael Köpcke und David Zubin (1996): „Prinzipien der Genuszuweisung im Deutschen“, in: Deutsch – typologisch, hrsg. v. Ewald Lang und Gisela Zifonun, Berlin/New York, S. 473-491.Elisabeth Leiss (2005): „Derivation als Grammatikalisierungsbrücke für den Aufbau von Genusdifferenzierungen im Deutschen“, in: Grammatikalisierung im Deutschen, hrsg. v. Torsten Leuschner, Tanja Mortelmans und Sarah De Groodt, Berlin/New York, S. 11-30. (Zitat zum parasitären Sexus auf S. 25).Damaris Nübling (2020): Genus und Geschlecht. Zum Zusammenhang von grammatischer, biologischer und sozialer Kategorisierung, Mainz/Stuttgart.Alle Bücher ausleihbar in deiner nächsten Bibliothek! ---Der World Atlas of Language Structures (kurz: WALS):Matthew S. Dryer, Matthew und Martin Haspelmath (Hrsg.) (2013): World Atlas of Language Structure Online (v2020.3). Zenodo: https://doi.org/10.5281/zenodo.7385533, URL: https://wals.info/.Daraus die beiden Karten ("Features"), die Jakob in der Folge erwähnt:30A: Number of Genders (von Greville G. Corbett)31A: Sex-based and Non-sex-based Gender Systems (von Greville G. Corbett)---Gegenüber Themenvorschlägen für die kommenden Ausflüge in die Sprachwissenschaft und Anregungen jeder Art sind wir stets offen. Wir freuen uns auf euer Feedback! Schreibt uns dazu einfach an oder in die DMs: anton.sprachpfade@protonmail.com oder jakob.sprachpfade@protonmail.com ---Grafiken und Musik von Elias Kündiger: https://on.soundcloud.com/ySNQ6

Hey Now, Cabalists! In 301 episode, Chris opens with his anthropological trip to Anthrocon. Then the gang dives into the games they've been playing including A Message from the Stars, Lacrimosa, Automobile, and Kingsburg. Chris and Jamie feature Forges of Ravenshire from Sam Stockton and B.A. Games. Then, Tony T. delivers his world-renowned tabletop gaming news segment, followed by a deep dive into "The Derivation of Joy" in gaming. Forges of Ravenshire 00:57:58, News with Tony T 01:34:40, The Derivation of Fun 02:41:06.

Send us a Text Message.Today's Episode:Word Formation in Norwegian: Compounding and DerivationThe Learn Norwegian Podcast is brought to you by the Norwegian Language School. Listening to our podcast is an enjoyable way to learn Norwegian at your own pace, whenever and wherever you are!Visit our website www.nlsnorwegian.no  or send an email to info@nlsnorwegian.no to sign up for Norwegian Classes!Support the Show.Register for Norwegian classesCheck your Norwegian level for free here

Happy Mayday! Apologies for the delay... this month for the May 2024 episode of the RCEM Learning Podcast Rob and Liz have two new in EM sections on the use of clonidine for pain and the use of coca cola in food boluses. We have a new Guidelines for EM section on The NEXUS Guidelines for Chest Imaging and then Rob speaks with Matt Reed about submitting your work for the RCEM Annual Scientific Conference. We then end with New Online. If you'd like to email us, please feel free to do so here. (01:56) New in EM - Clonidine for pain Effect of oral clonidine on pain reduction in patients with opioid use disorder in the emergency department: A randomized clinical trial (Rostamipoor et al., 2024) (17:44) Guidelines for EM - The NEXUS Guidelines for Chest Imaging A Pilot Study to Derive Clinical Variables for Selective Chest Radiography in Blunt Trauma Patients (Rodriguez et al., 2006) Derivation of a decision instrument for selective chest radiography in blunt trauma (Rodriguez et al., 2011) Derivation and validation of two decision instruments for selective chest CT in blunt trauma: a multicenter prospective observational study (NEXUS Chest CT) (Rodriguez et al., 2015) Evaluation of the Nexus X-ray rules in blunt thorax trauma (Acar et al., 2020) CT scanning in blunt chest trauma: validation of decision instruments (Reichardt et al., 2020) (49:28) Interview with Matt Reed (RCEM Research Committee Chair) RCEM Annual Scientific Conference 2024 Submitting your abstract to the RCEM Annual Scientific Conference 2024 (57:19) New in EM - Coca-cola for food bolus Efficacy of cola ingestion for oesophageal food bolus impaction: open label, multicentre, randomised controlled trial (Tievie et al., 2024) (01:13:24) New Online – new articles on RCEMLearning for your CPD Curriculum Cup (Neurology) - RCEMLearning Behaviours that Challenge - Liz Herrieven Sickle Cell Disease - Lisa Sabir, Roshan Cherian

Join guest host Cristina Fuss, MD, PhD, FSCCT as she takes a deep dive into featured articles in the January – February 2024 issue of the Journal of Cardiovascular Computed Tomography (JCCT). Our host chats with Dr. Lavinia Gabara, Dr. Kakuya Kitagawa and Dr. Armin Zadeh.This episode will explore:Derivation and validation of a novel Functional FFRCT Score incorporating the burden of coronary stenosis severity and flow impairment to predict clinical events Myocardial late enhancement and extracellular volume with single-energy, dual-energy, and photon-counting computed tomography Will GPT-Chat replace the Manuscript Review Process?Support the Show.

Commentary by Dr. Candice Silversides

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Generalized Stat Mech: The Boltzmann Approach, published by David Lorell on April 12, 2024 on LessWrong. Context There's a common intuition that the tools and frames of statistical mechanics ought to generalize far beyond physics and, of particular interest to us, it feels like they ought to say a lot about agency and intelligence. But, in practice, attempts to apply stat mech tools beyond physics tend to be pretty shallow and unsatisfying. This post was originally drafted to be the first in a sequence on "generalized statistical mechanics": stat mech, but presented in a way intended to generalize beyond the usual physics applications. The rest of the supposed sequence may or may not ever be written. In what follows, we present very roughly the formulation of stat mech given by Clausius, Maxwell and Boltzmann (though we have diverged substantially; we're not aiming for historical accuracy here) in a frame intended to make generalization to other fields relatively easy. We'll cover three main topics: Boltzmann's definition for entropy, and the derivation of the Second Law of Thermodynamics from that definition. Derivation of the thermodynamic efficiency bound for heat engines, as a prototypical example application. How to measure Boltzmann entropy functions experimentally (assuming the Second Law holds), with only access to macroscopic measurements. Entropy To start, let's give a Boltzmann-flavored definition of (physical) entropy. The "Boltzmann Entropy" SBoltzmann is the log number of microstates of a system consistent with a given macrostate. We'll use the notation: SBoltzmann(Y=y)=logN[X|Y=y] Where Y=y is a value of the macrostate, and X is a variable representing possible microstate values (analogous to how a random variable X would specify a distribution over some outcomes, and X=x would give one particular value from that outcome-space.) Note that Boltzmann entropy is a function of the macrostate. Different macrostates - i.e. different pressures, volumes, temperatures, flow fields, center-of-mass positions or momenta, etc - have different Boltzmann entropies. So for an ideal gas, for instance, we might write SBoltzmann(P,V,T), to indicate which variables constitute "the macrostate". Considerations for Generalization What hidden assumptions about the system does Boltzmann's definition introduce, which we need to pay attention to when trying to generalize to other kinds of applications? There's a division between "microstates" and "macrostates", obviously. As yet, we haven't done any derivations which make assumptions about those, but we will soon. The main three assumptions we'll need are: Microstates evolve reversibly over time. Macrostate at each time is a function of the microstate at that time. Macrostates evolve deterministically over time. Mathematically, we have some microstate which varies as a function of time, x(t), and some macrostate which is also a function of time, y(t). The first assumption says that x(t)=ft(x(t1)) for some invertible function ft. The second assumption says that y(t)=gt(x(t)) for some function gt. The third assumption says that y(t)=Ft(y(t1)) for some function Ft. The Second Law: Derivation The Second Law of Thermodynamics says that entropy can never decrease over time, only increase. Let's derive that as a theorem for Boltzmann Entropy. Mathematically, we want to show: logN[X(t+1)|Y(t+1)=y(t+1)]logN[X(t)|Y(t)=y(t)] Visually, the proof works via this diagram: The arrows in the diagram show which states (micro/macro at t/t+1) are mapped to which other states by some function. Each of our three assumptions contributes one set of arrows: By assumption 1, microstate x(t) can be computed as a function of x(t+1) (i.e. no two microstates x(t) both evolve to the same later microstate x(t+1)). By assumption 2, macrostate y(t) can be comput...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Generalized Stat Mech: The Boltzmann Approach, published by David Lorell on April 12, 2024 on LessWrong. Context There's a common intuition that the tools and frames of statistical mechanics ought to generalize far beyond physics and, of particular interest to us, it feels like they ought to say a lot about agency and intelligence. But, in practice, attempts to apply stat mech tools beyond physics tend to be pretty shallow and unsatisfying. This post was originally drafted to be the first in a sequence on "generalized statistical mechanics": stat mech, but presented in a way intended to generalize beyond the usual physics applications. The rest of the supposed sequence may or may not ever be written. In what follows, we present very roughly the formulation of stat mech given by Clausius, Maxwell and Boltzmann (though we have diverged substantially; we're not aiming for historical accuracy here) in a frame intended to make generalization to other fields relatively easy. We'll cover three main topics: Boltzmann's definition for entropy, and the derivation of the Second Law of Thermodynamics from that definition. Derivation of the thermodynamic efficiency bound for heat engines, as a prototypical example application. How to measure Boltzmann entropy functions experimentally (assuming the Second Law holds), with only access to macroscopic measurements. Entropy To start, let's give a Boltzmann-flavored definition of (physical) entropy. The "Boltzmann Entropy" SBoltzmann is the log number of microstates of a system consistent with a given macrostate. We'll use the notation: SBoltzmann(Y=y)=logN[X|Y=y] Where Y=y is a value of the macrostate, and X is a variable representing possible microstate values (analogous to how a random variable X would specify a distribution over some outcomes, and X=x would give one particular value from that outcome-space.) Note that Boltzmann entropy is a function of the macrostate. Different macrostates - i.e. different pressures, volumes, temperatures, flow fields, center-of-mass positions or momenta, etc - have different Boltzmann entropies. So for an ideal gas, for instance, we might write SBoltzmann(P,V,T), to indicate which variables constitute "the macrostate". Considerations for Generalization What hidden assumptions about the system does Boltzmann's definition introduce, which we need to pay attention to when trying to generalize to other kinds of applications? There's a division between "microstates" and "macrostates", obviously. As yet, we haven't done any derivations which make assumptions about those, but we will soon. The main three assumptions we'll need are: Microstates evolve reversibly over time. Macrostate at each time is a function of the microstate at that time. Macrostates evolve deterministically over time. Mathematically, we have some microstate which varies as a function of time, x(t), and some macrostate which is also a function of time, y(t). The first assumption says that x(t)=ft(x(t1)) for some invertible function ft. The second assumption says that y(t)=gt(x(t)) for some function gt. The third assumption says that y(t)=Ft(y(t1)) for some function Ft. The Second Law: Derivation The Second Law of Thermodynamics says that entropy can never decrease over time, only increase. Let's derive that as a theorem for Boltzmann Entropy. Mathematically, we want to show: logN[X(t+1)|Y(t+1)=y(t+1)]logN[X(t)|Y(t)=y(t)] Visually, the proof works via this diagram: The arrows in the diagram show which states (micro/macro at t/t+1) are mapped to which other states by some function. Each of our three assumptions contributes one set of arrows: By assumption 1, microstate x(t) can be computed as a function of x(t+1) (i.e. no two microstates x(t) both evolve to the same later microstate x(t+1)). By assumption 2, macrostate y(t) can be comput...

Question: Who conducts derivation proceedings, inter partes reviews, and post-grant reviews? Answer: The Board is to conduct derivation proceedings, inter partes reviews, and post-grant reviews. Chapter Details: This question comes from the following supplement “Patent Trial and Appeal Board Consolidated Trial Practice Guide November 2019”. This is a special supplement that at the time of this recording is currently being tested on the Patent Bar exam. Depending on future changes to the supplement and the MPEP, the question and answer may not be applicable. Section Summary: This question comes from the following supplement: “Patent Trial and Appeal Board Consolidated Trial… The post MPEP Q & A 293: Who conducts derivation proceedings, inter partes reviews, and post-grant reviews? appeared first on Patent Education Series.

Question: When did the derivation rules go into effect? Answer: The derivation rules went into effect 18 months after AIA enactment (March 16, 2013). Chapter Details: This question comes from the following supplement “Patent Trial and Appeal Board Consolidated Trial Practice Guide November 2019”. This is a special supplement that at the time of this recording is currently being tested on the Patent Bar exam. Depending on future changes to the supplement and the MPEP, the question and answer may not be applicable. Section Summary: This question comes from the following supplement: “Patent Trial and Appeal Board Consolidated Trial Practice… The post MPEP Q & A 291: When did the derivation rules go into effect? appeared first on Patent Education Series.

Dr. Haytham Kaafarani is a trauma surgeon at Massachusetts General Hospital. We caught up with him after he recently gave a phenomenal talk at the Canadian Surgical Forum in Vancouver earlier this year. Dr. Kaafarani talked about his work in Lebanon after the explosion in 2020, his research on intra operative adverse events, and ultimately on his work as surgeons as second victims. This episode is a clarion call for surgeons everywhere to develop these support systems for each other. Links: 1. Intraoperative Adverse Events in Abdominal Surgery: What Happens in the Operating Room Does Not Stay in the Operating Room. https://pubmed.ncbi.nlm.nih.gov/27805961/ 2. Derivation and validation of a novel severity classification for intraoperative adverse events. https://pubmed.ncbi.nlm.nih.gov/24702887/ 3. The Surgeon as the Second Victim? Results of the Boston Intraoperative Adverse Events Surgeons' Attitude (BISA) Study. https://pubmed.ncbi.nlm.nih.gov/28093300/ 4. Design and Impact of a Novel Surgery-Specific Second Victim Peer Support Program. https://journals.lww.com/journalacs/abstract/2020/06000/design_and_impact_of_a_novel_surgery_specific.16.aspx

Join us as we try one of the latest editions from the Derivation line of barrel aged stouts from Side Project Brewing out of Maplewood, MO (STL area).  Is Derivation, Blend 17 the best one yet?  Tune in to find out!Special guest on this episode, our friend Andrew Hatfield (Assistant GM and Spirits Trainer for Liquor Barn)https://tinyurl.com/Derivation-17#derivation #sideproject #barrelaged #stout #beer #beerreview #beerreviews #beerreviewer #ourcynicculturehttps://www.youtube.com/channel/UCpEcWikZ55QHotmldjuKVawhttps://www.instagram.com/ourcynicculture/https://www.tiktok.com/@ourcynicculture?lang=enhttps://twitter.com/ourcynicculturehttps://www.facebook.com/ourcynicculture

2023 Neurocritical Care Society Annual Meeting Pharmacist-featured research 02:24 – Multicenter comparison of the safety and efficacy of clopidogrel versus ticagrelor for neuroendovascular stents featuring Casey May, PharmD, BCCCP, FNCS 15:24 – Prevalence of augmented renal clearance in neurocritical care population: a prospective multicenter study (Neuro-ARC study) featuring Sherif Mahmoud, BSc (Pharm), MSc, PhD, FNCS 24:41 – Derivation and validation of an equation to predict free valproate concentration in intensive care patients featuring Ji Liu, PharmD, BCCCP 43:05 – Effect of IV push levetiracetam and lacosamide implementation on turn-around times and cost featuring Veronica Bonderski, PharmD, BCCCP 53:25 – Neurostimulant prescription rates in patients with neurologic injuries AND  Statin effects on inflammatory biomarker concentrations in patients with mild traumatic brain injury: a potential target for intervention featuring Sulaiman Almohaish, PharmD, BCPS and Gretchen Brophy, PharmD, BCPS, FCCP, FCCM, FNCS, MCCM 66:20 – Effect of melatonin on the use of antipsychotic medications in the intensive care unit featuring Madeline Mitchell, PharmD, BCPS 77:10 – Pharmacists decrease number of protocol discordant four-factor prothrombin complex concentrate orders for oral anticoagulant-associated intracranial hemorrhage in a community emergency department featuring Ifoma Ofoegbuna, PharmD, BCCCP 84:12 – Clinical pharmacist-driven electronic data capture of medication administration records in the ELECTRO-BOOST multicenter study featuring Andy Webb, PharmD, BCCCP Link to research poster PDFs: https://pharmacytodose.com/2023/09/13/2023-ncs-pharmd-research-highlights/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Sponsored by Rabbi Hidary's Wednesday Night Class! See all recordings at https://www.rabbinics.org/daf-yomi-bridge.

In this podcast with Michael Rosenbaum and Ellen Seigel, we explore how the energy of love is at the very center of all form, no matter what form it is, at the heart of every atom. How this is a portal back to God or the absolute consciousness that is the intelligence at the center of all form. We also discuss how to use this to dip into the experience of this energy and create a more beautiful and balanced life for yourself. the discussion is based on information that was given to me in meditation as a way to help me go deeper into my spiritual nature. Here is the info exactly as it was given to me so you can refer to it. It uses the word "God" because for me it means the absolute and formless backdrop of all experience. Just plug in the word that points to that for you. Love and it's purpose and derivation The intelligence that is behind all form comes out of the vibration of love…. the intelligent of love is the intelligence of joining, accepting, inviting…. every form has built into it the vibration of the intelligence of love… like a hologram it is in every cell, every atom…. the loving and inclusive energy of the great central sun that you experienced is the same energy, the same magnetic pull that is at the center of all atoms…. it is the void or the black hole that is at the center of all form that draws you back into love, which is another way of saying back into God…. get to know this aspect of yourself and you will know God…. it is the only way to really know God….. so continue to practice in meditation, in your daily life, when you walk in nature, when you wake up, in your dreams, in all of your experiences in all of the moments of now keep feeling the magnetic pull of love that is at the center of the universe and the center of all form…. it is the gateway to the formless and the gateway to love…. love and the formless are the same word….. approach all adversity that you encounter in life from the energy of the formless love… this love just radiates and does not ask for change, does not try to change the form or situation, it just radiates out…. it is this radiation that stimulates the same radiation in other forms for that love radiation, that formless entrance exists in all form no matter the expression of it…. by radiating this vibration of formless love you will do more to help balance someone or a situation then any doing you can do…. this force is so magnetic, so attractive that it never elicits a resistant response…. it allows the other person and the situation to begin to vibrate with it, it can help but vibrate with it to some degree…. as the person or situation begins to vibrate with it, it begins to allow God in and begins the process of surrendering to the God in it and allowing that to overtake it and in that way love and balance it, using it's own intelligence of love…. that is all you need to ever do…. just keep learning more about how to access the magnetic intelligence in you and experience it and then use that experience in all your interactions…. when you do this you will get closer and closer to God and the mystery of life will be revealed more and more….life becomes more and more joyous and your ability to be swallowed up in the magnetic pull of intelligent love increases and so does your joy and your wonder and your appreciation.  

1. Abelian Group: Actual Definition: An Abelian group, named after Niels Henrik Abel, is a group in which the binary operation is commutative, meaning that for all elements a and b in the group, a * b = b * a. Etymological Definition and Derivation: The term "Abelian" pays homage to the Norwegian mathematician Niels Henrik Abel, who made significant contributions to the theory of equations and group theory. The word "Abelian" is derived from the Latin word "Abelius," signifying Abel's enduring legacy. 2. Euclidean Geometry: Actual Definition: Euclidean geometry, introduced by the ancient Greek mathematician Euclid, is a branch of mathematics that deals with properties, relationships, and measurements of points, lines, angles, and surfaces in the plane and space, based on Euclid's five postulates. Etymological Definition and Derivation: "Euclidean" honors the legendary Greek mathematician Euclid, a beacon of geometrical elucidation. Rooted in the Greek term "Euclides," it resonates with the man's enduring dedication to the exploration of space. 3. Calculus: Actual Definition: Calculus is a branch of mathematics that explores the concepts of limits, derivatives, integrals, and infinite series, enabling the analysis of change and accumulation in various contexts. Etymological Definition and Derivation: "Calculus" emerges from the Latin "calculus," a diminutive of "calx," meaning a small stone used in counting and calculations. It was birthed by minds like Newton and Leibniz, who sculpted this art of calculation to harness the elusive infinitesimal. 4. Topology: Actual Definition: Topology is a field of mathematics that examines the properties of space that are preserved under continuous deformations, including concepts like continuity, convergence, compactness, and connectedness. Etymological Definition and Derivation: "Topology" emerges from the Greek roots "topos" (place) and "logos" (study), a testament to the exploration of spatial relations. Its true essence resides in the intimate scrutiny of shapes' essence beyond rigid measurements. 5. Eigenvalue: Actual Definition: In linear algebra, an eigenvalue of a matrix represents a scalar value that characterizes how a matrix transforms a vector, with the vector only scaling by the eigenvalue during the transformation. Etymological Definition and Derivation: "Eigenvalue" springs from the German "eigen," meaning inherent or characteristic, and "value." It encapsulates the distinct nature of values that a matrix uniquely possesses, much like a signature of its intrinsic behavior. 6. Homomorphism: Actual Definition: A homomorphism is a structure-preserving map between two algebraic structures, such as groups, rings, or vector spaces, that preserves the operations and relationships between elements. Etymological Definition and Derivation: "Homomorphism" finds its roots in the Greek "homos" (same) and "morphē" (form). This term embodies the lofty concept of maintaining similarity, preserving the integrity of structures across mathematical realms. 7. Fractal: Actual Definition: A fractal is a complex geometric shape or pattern that displays self-similarity at various scales, exhibiting intricate detail regardless of the level of magnification. Etymological Definition and Derivation: "Fractal" derives from the Latin "fractus," meaning broken or fractured. Coined by Benoît B. Mandelbrot, this term encapsulates the enigmatic beauty of structures that break free from the linear constraints of Euclidean space. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

Join experts Drs Matt Sparks and Dawn Caster as they discuss the complexities around the management of lupus nephritis. What tools do we have now? What is on the horizon? Tune in to find out. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/991602). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Novel Aspects in the Pathophysiology and Diagnosis of Glomerular Diseases https://pubmed.ncbi.nlm.nih.gov/36535746/ Derivation and Validation of the Systemic Lupus International Collaborating Clinics Classification Criteria for Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/22553077 EULAR/ACR Classification Criteria for SLE https://pubmed.ncbi.nlm.nih.gov/31779843/ Sensitivity and Specificity of ANA and Anti-dsDNA in the Diagnosis of Systemic Lupus Erythematosus: A Comparison Using Control Sera Obtained From Healthy Individuals and Patients With Multiple Medical Problems https://pubmed.ncbi.nlm.nih.gov/24383972/ Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice https://pubmed.ncbi.nlm.nih.gov/34568396/  KDIGO 2023 Clinical Practice Guideline for the Management of Lupus Nephritis https://kdigo.org/wp-content/uploads/2023/03/KDIGO-2023-Lupus-Nephritis-Guideline_Public-Review_9-Mar-2023.pdf Management of Lupus Nephritis: A Systematic Literature Review Informing the 2019 Update of the Joint EULAR and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) Recommendations https://pubmed.ncbi.nlm.nih.gov/32699043/ Nonrenal Disease Activity Following Mycophenolate Mofetil or Intravenous Cyclophosphamide as Induction Treatment for Lupus Nephritis: Findings in a Multicenter, Prospective, Randomized, Open-Label, Parallel-Group Clinical Trial https://pubmed.ncbi.nlm.nih.gov/20039429/ Immunosuppressive Therapy in Lupus Nephritis: The Euro-Lupus Nephritis Trial, a Randomized Trial of Low-Dose Vs High-Dose Intravenous Cyclophosphamide https://pubmed.ncbi.nlm.nih.gov/12209517/ Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis https://pubmed.ncbi.nlm.nih.gov/35168373 Safety and Efficacy of Belimumab in Patients With Lupus Nephritis: Open-Label Extension of BLISS-LN Study https://pubmed.ncbi.nlm.nih.gov/36302567/ Anti-CD19 CAR T Cell Therapy for Refractory Systemic Lupus Erythematosus https://pubmed.ncbi.nlm.nih.gov/36109639/ Dapagliflozin in People With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/37257897/ Empagliflozin in Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/36331190/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.03.547465v1?rss=1 Authors: Sheheitli, H., Jirsa, V. Abstract: We derive a next generation neural mass model of a population of quadratic-integrate-and-fire neurons, with slow adaptation, and conductance-based AMPAR, GABAR and nonlinear NMDAR synapses. We show that the Lorentzian ansatz assumption can be satisfied by introducing a piece-wise polynomial approximation of the nonlinear voltage-dependent magnesium block of NMDAR current. We study the dynamics of the resulting system for two example cases of excitatory cortical neurons and inhibitory striatal neurons. Bifurcation diagrams are presented comparing the different dynamical regimes as compared to the case of linear NMDAR currents, along with sample comparison simulation time series demonstrating different possible oscillatory solutions. The omission of the nonlinearity of NMDAR currents results in a shift in the range (and possible disappearance) of the constant high firing rate regime, along with a modulation in the amplitude and frequency power spectrum of oscillations. Moreover, nonlinear NMDAR action is seen to be state-dependent and can have opposite effects depending on the type of neurons involved and the level of input firing rate received. The presented model can serve as a computationally efficient building block in whole brain network models for investigating the differential modulation of different types of synapses under neuromodulatory influence or receptor specific malfunction. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this JCO Article Insights episode, Emily Zabor summarizes two original articles from the June 1st, 2023 Journal of Clinical Oncology issue: “A Clinical Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts”  by Muñoz et al,  and “Derivation and Validation of Clinical Risk Assessment Model for Cancer Associated Thrombosis in Two Unique Healthcare Systems” by Li et al, as well as the accompanying editorial “Fine Tuning Venous Thromboembolism Risk Prediction in Patients with Cancer” by Jean Marie Connors. The original reports describe the development and validation of two new risk prediction models for venous thromboembolism in cancer patients and the editorial puts them into context of existing tools. TRANCRIPT  The guest on this podcast episode has no disclosures to declare. Emily Zabor: Welcome to JCO Article Insights for the June 1st, 2023 issue of JCO. I'm your host, Emily Zabor, JCO Biostatistics Editorial Fellow. Today, I will be providing summaries of three articles.  The first article, titled “A Clinical Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts” by Andres Muñoz and colleagues, describes the development and validation of a risk score for venous thromboembolism in oncology patients based on both clinical and genetic features, called the ONCOTHROMB score. In developing this model, the authors sought to address the fact that venous thromboembolism is among the leading causes of death among patients with cancer. Whereas hospitalized cancer patients are typically treated with thromboprophylaxis, outpatient treatment with thromboprophylaxis is only suggested for patients at high risk for venous thromboembolism identified according to the Khorana score.  The authors sought to determine whether incorporation of known genetic risk factors along with clinical factors would result in improved predictive accuracy. The risk score was developed in a cohort of 364 patients and was validated in an external cohort of 263 patients. The primary outcome of interest was venous thromboembolism within six months of a cancer diagnosis. The authors used logistic regression with backward selection with a p-value threshold of 0.25 to first select the genetic variants to include in the genetic risk score and then to separately select the clinical features to incorporate. Then the genetic risk score and clinical features were combined into a single multivariable logistic regression model, and backward selection was performed again.  The final model included nine genetic variants, tumor site, TNM stage, and a BMI of greater than 25. In the validation data, the ONCOTHROMB score using a threshold selected with the Youden index resulted in an AUC of 0.686 as compared to an AUC of 0.577 for the Khorana score with a threshold of 3. The ONCOTHROMB score had statistically significantly higher sensitivity, whereas the Khorana score had statistically significantly higher specificity. The authors conclude that the ONCOTHROMB score demonstrated improved predictive ability and should be investigated further in clinical trials.  The second article, titled “Derivation and Validation of Clinical Risk Assessment Model for Cancer Associated Thrombosis in Two Unique Healthcare Systems” by Ang Li and colleagues, describes the development and validation of a risk assessment model for venous thromboembolism, pulmonary embolism, and lower-extremity deep vein thrombosis in oncology patients undergoing systemic therapy. The authors developed this model to address the increased morbidity and mortality associated with venous thromboembolism among cancer patients and the fact that risk reduction for use of thromboprophylaxis as well as the efficacy-safety trade-off, and cost-effectiveness have been shown to be higher among patients selected as high risk for venous thromboembolism.  The primary outcome was venous thromboembolism within six months of treatment initiation. In the development data set, the authors used lasso-penalized logistic regression analysis to shrink some of the covariates to zero as a form of variable selection, then a multivariable logistic regression model was fit to the remaining covariates and those with an estimated odds ratio greater than 1.2 or less than 0.8 were retained in the final model. A linear risk score was created from the resulting beta coefficients. The risk assessment model was developed in a cohort of 9769 patients and validated in an external cohort of 79,517 patients. The final model included eleven factors: cancer subtype, pre-therapy BMI greater than or equal to 35, pre-therapy white blood cell count greater than 11, pre-therapy hemoglobin less than 10, pre-therapy platelet greater than or equal to 350, cancer staging 3 to 4, targeted or endocrine monotherapy, lifetime history of venous thromboembolism, history of paralysis and immobility in the last 12 months, recent hospitalization lasting greater than three days in the last three months, and Asian Pacific Islander race.   The final linear risk score was stratified into six categories and then dichotomized based on overall venous thromboembolism incidence of 7%, resulting in about half of the patient population being classified as high risk for venous thromboembolism. In the validation data, the model was associated with a c-statistic of 0.68 as compared to 0.6 for the Khorana score with a threshold of 2. Sensitivity analyses demonstrated that the model had similar discrimination in subgroups according to age, sex, and race-ethnicity. The authors conclude that their new risk assessment model has the potential to improve patient selection for thromboprophylaxis. The third and final article titled “Fine Tuning Venous Thromboembolism Risk Prediction in Patients with Cancer” by Jean Marie Connors, is an editorial accompanying the two previously summarized articles. Dr. Connors emphasizes that venous thromboembolism is the second leading cause of death in cancer patients, second only to cancer itself, and that while treatment with thromboprophylaxis has been shown to significantly reduce the occurrence of venous thromboembolism in randomized controlled trials, since the overall risk of venous thromboembolism is so low, treating all patients would result in significant overtreatment. Therefore, prediction tools are needed and many have been developed, with the Khorana score being the most widely used because it is the best validated and easy to calculate.   Dr. Connors observes that in the risk assessment model by Li and colleagues, more granularity is added to the  Khorana score by stratifying gastrointestinal cancer subtypes and by adding aggressive NHL, myeloma, brain tumors, and sarcoma, and also incorporates additional cancer-specific and patient-specific risk factors. But while this risk assessment model reclassified approximately 25% of patients in both the development and validation sets, as compared to the Khorana score, there was only modest improvement in discrimination. With the c-index improving from 0.65 to 0.71 in the development set and from 0.6 to 0.68 in the validation set from the Khorana score to the new risk assessment model.   On the other hand, the ONCOTHROMB score developed by Muñoz and colleagues contains fewer clinical features as compared to the Khorana score but adds a genetic risk score based on eleven genetic variants. The Khorana score performed quite poorly in both the development and validation data in this study, with AUCs of just 0.58 and 0.56, so improvements to 0.781 and 0.720 were relatively large. Connors notes that prospective validation of both scores is still needed, especially of the ONCOTHROMB score in more diverse populations, as allele frequencies can vary widely and the studied populations were predominantly Western European. Connors cautions that there is still a need to demonstrate mortality benefit from venous thromboembolism prophylaxis and that the risk of bleeding and other complications must be properly weighed against the benefits.  That concludes this episode on the articles “A Clinical Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts” and “Derivation and Validation of Clinical Risk Assessment Model for Cancer Associated Thrombosis in Two Unique US Healthcare Systems,” and the associated editorial, “Fine Tuning Venous Thromboembolism Risk Prediction in Patients with Cancer.” Thank you for listening and please tune in for the next issue of JCO Article Insights.  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Like, share, and subscribe so you never miss an episode and leave a rating or review.  Editorial:   Fine Tuning Venous Thromboembolism Risk Prediction in Patients With Cancer Derivation and Validation of a Clinical Risk Assessment Model for Cancer-Associated Thrombosis in Two Unique US Health Care Systems A Clinical-Genetic Risk Score for Predicting Cancer-Associated Venous Thromboembolism: A Development and Validation Study Involving Two Independent Prospective Cohorts Original Report:   Find more articles from the June 1 issue  

In this episode, we talk to Dr James Sheppard, who is an Associate Professor at the Nuffield Department of Primary Care Health Sciences at the University of Oxford. Title of paper: Predicting the risk of acute kidney injury: Derivation and validation of STRATIFY-AKIAvailable at: https://doi.org/10.3399/BJGP.2022.0389Acute kidney injury (AKI) is one of the more serious adverse events associated with antihypertensive treatment, reducing an individual's health-related quality of life and increasing the risk of admission to hospital. Clinical guidelines recommend that when prescribing antihypertensives GPs should take into account the likelihood of both the benefits and harms from treatment, but few data exist in regard to the risk of AKI. A clinical prediction model was developed and externally validated for the risk of AKI up to 10 years in the future in patients eligible for antihypertensive medication, incorporating commonly recorded patient characteristics, comorbidities, and prescribed medications. The model showed good discrimination and good calibration for probabilities up to 20%, enabling GPs to accurately identify patients at higher risk of AKI. This could be useful to reassure the majority of patients starting or continuing treatment that their risk of AKI is very low.

Dr. Rebecca King reviews the article, “Derivation of the Buffalo Concussion Physical Examination Risk of Delayed Recovery (RDR) Score to Identify Children at Risk for Persistent Post-Concussive Symptoms,” which was originally published in the British Journal of Sports Medicine in December 2021. Dr. Jeremy Schroeder serves as moderator. Dr. King is a member of the AMSSM Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2021, as selected for the 2022 AMSSM Annual Meeting in Austin, TX.   Derivation of the Buffalo Concussion Physical Examination Risk of Delayed Recovery (RDR) Score to Identify Children at Risk for Persistent Post-Concussive Symptoms DOI: 10.1136/bjsports-2020-103690

Jaime Paul Lamb: Georeferential Dynamics and derivation of Hermetic Time 

BAKER: Georeferential Dynamics and derivation of Hermetic Time 

Sponsored by Dr. Charles Piwko in memory of רות בת צבי.

Malcolm and Kurt trade barbs and witticisms while puzzling out the derivations of common English phrases while also celebrating the 30-year anniversary of an amazing word-related hoax perpetrated by a member of Generation X against the mighty New York Times.

Support this podcast with a small monthly donation to help sustain future episodes. Please use the links below: Support Via PayPal https://www.paypal.com/donate/?hosted_button_id=TLHBRAF6GVQT6 Support via card https://swiftpay.accessbankplc.com/OsazuwaAkonedo/send-money This episode is also available as a blog post: https://osazuwaakonedo.news/how-edo-received-n18-2b-delta-n129-5b-oil-derivation-refund-2021-2022-fg/03/12/2022/ How Edo Received N18.2b, Delta N129.5b Oil Derivation Refund 2021-2022 - FG ~ OsazuwaAkonedo ###Muhammadu ##Obaseki #2022 #Abia #Accountant #Adams #Buhari #Delta #Derivation #edo #Godwin #government #Ifeanyi #Imo #Nyesom #Oil #Okowa #Ondo #OsazuwaAkonedo #Oshiomhole https://osazuwaakonedo.news/how-edo-received-n18-2b-delta-n129-5b-oil-derivation-refund-2021-2022-fg/03/12/2022/ By Garba Shehu --- Send in a voice message: https://anchor.fm/osazuwaakonedo/message Support this podcast: https://anchor.fm/osazuwaakonedo/support

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Wed, 23 Nov 2022 10:37:04 GMT 62cf4c95-99a3-4253-a4d0-4ede77ee584e Olayemi and Co. 2022-11-23T10:37:04Z 01:04:26 Inform Me ( 13% Oil Derivation

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I read from deportation to depravity.     Derbyshire! https://en.wikipedia.org/wiki/Derbyshire     The word of the episode is "deregulation".     Theme music from Tom Maslowski https://zestysol.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

Since Jon Bampton (J-Bam) of The Dirty Harry Minute unfortunately couldn't make it back today, Rob was joined instead at the last moment by Alan Sanders of The Wilder Ride and The Marriage Fit Podcast to discuss the beginning of the conversation between John and Ellis.

Dans cet épisode, nous avons invité le Dr Vincent Joris, un neurochirurgien, pour nous parler de l'hydrocéphalie. Vous trouverez ainsi plusieurs explications et les éléments clés afin de mieux comprendre l'hydrocéphalie. Si vous avez des questions et/ou vous aimeriez nous livrer votre témoignage ou nous parler d'un sujet qui met à l'honneur la différence dans notre société, vous pouvez nous écrire à margauxasbhq@gmail.com. On vous lira et vous répondra.

Richard Easther is a scientist, teacher, and communicator. He has been a Professor of Physics at the University of Auckland for over the last 10 years and was previously a professor of physics at Yale University. As a scientist, Richard covers ground that crosses particle physics, cosmology, astrophysics and astronomy, and in particular, focuses on the physics of the very early universe and the ways in which the universe changes between the Big Bang and the present day. In this episode, Richard and I discuss the details of cosmology at large, both technically and historically. We dive into Einstein's equations from general relativity and see what implications they have for an expanding universe alongside a discussion of the cast of characters involved in 20th century cosmology (Einstein, Hubble, Friedmann, Lemaitre, and others). We also discuss inflation, gravitational waves, the story behind Brian Keating's book Losing the Nobel Prize, and the current state of experiments and cosmology as a field.   Originally published on May 3, 2022 on YouTube:  https://youtu.be/DiXyZgukRmE Timestamps: 00:00:00 : Introduction 00:02:42 : Astronomy must have been one of the earliest sciences 00:03:57 : Eric Weinstein and Geometric Unity 00:13:47 : Outline of podcast 00:15:10 : Brian Keating, Losing the Nobel Prize, Geometric Unity 00:16:38 : Big Bang and General Relativity 00:21:07 : Einstein's equations 00:26:27 : Einstein and Hilbert 00:27:47 : Schwarzschild solution (typo in video) 00:33:07 : Hubble 00:35:54 : One galaxy versus infinitely many 00:36:16 : Olbers' paradox 00:39:55 : Friedmann and FRLW metric 00:41:53 : Friedmann metric was audacious? 00:46:05 : Friedmann equation 00:48:36 : How to start a fight in physics: West coast vs East coast metric and sign conventions. 00:50:05 : Flat vs spherical vs hyperbolic space 00:51:40 : Stress energy tensor terms 00:54:15 : Conversation laws and stress energy tensor 00:58:28 : Acceleration of the universe 01:05:12 : Derivation of a(t) ~ t^2/3 from preceding computations 01:05:37 : a = 0 is the Big Bang. How seriously can we take this? 01:07:09 : Lemaitre 01:11:51 : Was Hubble's observation of an expanding universe in 1929 a fresh observation? 01:13:45 : Without Einstein, no General Relativity? 01:14:45 : Two questions: General Relativity vs Quantum Mechanics and how to understand time and universe's expansion velocity (which can exceed the speed of light!) 01:17:58 : How much of the universe is observable 01:24:54 : Planck length 01:26:33 : Physics down to the Big Bang singularity 01:28:07 : Density of photons vs matter 01:33:41 : Inflation and Alan Guth 01:36:49 : No magnetic monopoles? 01:38:30 : Constant density requires negative pressure 01:42:42 : Is negative pressure contrived? 01:49:29 : Marrying General Relativity and Quantum Mechanics 01:51:58 : Symmetry breaking 01:53:50 : How to corroborate inflation? 01:56:21 : Sabine Hossenfelder's criticisms 02:00:19 : Gravitational waves 02:01:31 : LIGO 02:04:13 : CMB (Cosmic Microwave Background) 02:11:27 : Relationship between detecting gravitational waves and inflation 02:16:37 : BICEP2 02:19:06 : Brian Keating's Losing the Nobel Prize and the problem of dust 02:24:40 : BICEP3 02:26:26 : Wrap up: current state of cosmology Notes: Easther's blogpost on Eric Weinstein: http://excursionset.com/blog/2013/5/25/trainwrecks-i-have-seen Vice article on Eric Weinstein and Geometric Unity: https://www.vice.com/en/article/z3xbz4/eric-weinstein-says-he-solved-the-universes-mysteries-scientists-disagree   Further learning: Matts Roos. "Introduction to Cosmology" Barbara Ryden. "Introduction to Cosmology" Our Cosmic Mistake About Gravitational Waves: https://www.youtube.com/watch?v=O0D-COVodzY

In this episode, Donald Knuth discusses the mathematical theory of derivation, or mordants. Interestingly, these concepts are of fundamental importance to the field of cryptography and data security.

Script: https://tcmpodcast.me/episode-06-rise-of-nomad-destinations/ The cupping therapy has been used in China for thousands of years. The cupping therapy in its primitive form using cattle horn was used primarily to withdraw pus and blood in the treatment of boils. Cupping was then used as an auxiliary method in traditional Chinese surgery, and in time developed into a special therapeutic method. The earliest records of cupping in ancient China was found written in Bo Shu 帛书 ancient book written on silk. The text were buried 186 BC in Ma wang dui 马王堆 tomb. Through several thousand years of accumulated clinical experience, the clinical applications of cupping have become increasingly wide. During the Qing dynasty 清代 (1644-1911), the original natural horn cup has been replaced by bamboo, ceramic or glass cups. Because cupping is traditionally used in China, the technique has been inherited by the modern Chinese TCM doctors. The ancient Egyptians were the first to use cupping therapy systematically. Ebers Papyrus, the oldest medical textbook 1550 BC, describes bleeding by cupping in order to “remove the foreign matter from the body”. Hippocrates and Galen were also great advocates of cupping. In the early days the technique was used solely for bleeding purposes. In the book of Galen (c. 129-200 AD) on Bloodletting, disease and health are defined in terms of nature. “Disease is an unnatural state of the body”, states Galen, “which impairs a function. Health is a state in accordance with nature, and the cause of the functions”. Here we can see the similarities to the cause of disease and the theory of Traditional Chinese Medicine (TCM): disease occurs as a result of imbalance between the Yin and the Yang. Galen states that: “The nature does its best to restore unnatural states to their healthy condition. The function of the Physician is to cooperate with her. The principal indication for Bloodletting, then, is to eliminate such residues or to divert blood from one part to another by the process known as Revulsion or Derivation”. For thousands of years all medical authors have distinguished two forms of cupping, Dry and Wet. In Dry cupping no blood is actually removed from the body. A cup is drained of air and applied to the skin, causing the skin to swell. In Wet cupping the process begins with dry cupping and is followed by several incisions being made in the skin, in order to collect blood. Among the Egyptians, who introduced bloodletting to Greece, cupping was the usual remedy for almost every disorder, and they no doubt had received it from the more ancient nations of the East, from whom they had derived their other knowledge. In many cases, topical abstraction of blood alone is indicated, and this can only be effected by using leeches or cupping. Leeches have been found so uncertain in their application that various means have been prescribed to make them more effective. Info: www.tcmpodcast.me        

Episode 23 (Video on Youtube, Listen on Spotify and Apple Podcasts)Linktree - For Certain Uncertainty PlatformsJon and Joe discuss topics on:- The derivation of human commitment - How do we define and maintain commitmentEvery Monday at 12:00 pm (PST)

Derivation and validation of the ExCare model for mortality risk stratification is this BJANcast's main theme with Dr. Savio Cavalcante Passos, do Hospital das Clínicas de Porto Alegre. You can read the article clicking on the link. Dr. Savio Cavalcante Passos e-mail: scpassos@hcpa.edu.br #citeBJAN #joinBJAN #BJANcast Social Networks: bjan-sba.org Instagram Facebook LinkedIn Twitter

As the BFGs enter the Citadel of Mist, they find themselves in a very deceptive conversations it leads them to a crossroad where they must make several difficult decisions and Saesha learns a truth she may not be ready to accept. Watch D4 LIVE every SunD4y at 4p PT/7p ET on twitch.tv/d4rpg with the podcast releasing every Friday! For more info visit our website at d4dndrpg.com

Sponsored by David and Lillian Khaski in honor the birth of their triplets.

Dedicated by Dr. Edward J Gindi in memory of his parents Joseph and Grace Gindi A"H A. Derivation of many days: Zemanehim Like the Days B. Baraita of R. Yehuda Two versions Contradicts next Mishnah C. Source that walled cities are on Adar 15 D. Opinion that walled cities from time of Ahashverosh

Bomphcast Audio welcome Leipzig producer I-G.L.O to the label. His For the Earth Existence is a collection of moods that blends his understanding of classical music with contemporary techno. Pre-orders are available now on our Bandcamp page. The EP is an expression of I-G.L.O's feelings during the course of the pandemic. "For the EP, I've tried to have moody deeper, mysterious tracks and some more uplifting feelings to understate the different affections that came for me during this whole end of Summer/Autumn." Says I-G.L.O. Bomphcast favorite Franz Jäger provides his take on I-G.L.O's Derivation of Life with a club focused remix. For the Earth Existence by I-G.L.O Mastering by Fergus Sweetland. Artwork by Liam White. Graphic Design by Emily Stoll. Distributed by Triple Vision.

Bomphcast Audio welcome Leipzig producer I-G.L.O to the label. His EP For the Earth Existence is a collection of moods that blends his understanding of classical music with contemporary techno. The EP is an expression of I-G.L.O's feelings during the course of the pandemic. "For the EP, I've tried to have moody deeper, mysterious tracks and some more uplifting feelings to understate the different affections that came for me during this whole end of Summer/Autumn." Says I-G.L.O. Bomphcast favorite Franz Jäger provides his take on I-G.L.O's Derivation of Life with a club focused remix. For the Earth Existence by I-G.L.O Mastering by Fergus Sweetland. Artwork by Liam White. Graphic Design by Emily Stoll. Distributed by Triple Vision.

TODAY'S GUESTS In this episode of Remake, I sit down with Ana Ferreira and Alex Muench. Ana is Head of Design and Product Design, and Alex is a senior digital product designer at Doist, a completely remote team of over 100 people, and the maker of popular productivity apps, Todoist and Twist. Ana and Alex are the creators of Twist, a remarkable and opinionated communication tool aimed at replacing Slack with a less distracting, more focused supporting, less real-time alternative. We've been using Twist for a few months at Remake, and it has done wonders for our ability to communicate remotely across time zones, to stay up-to-date, and catch up when our work allows rather than disrupting work to be always connected. I really can't overstate how much more harmonious and effective work has become since we moved out of real-time chat tools. And a lot of this goes back to Ana and Alex's ideas and the company's opinionated take on work, communication and design.   EPISODE SUMMARY In this conversation we talk about: What it means to be a designer. What makes Doist special as a company. What's wrong with "always on" team chat tools like Slack, Microsoft Teams and Google's team chat, and the culture of availability and distraction they promote. What it takes to be an effective distributed team. This chat with Ana and Alex is just one of dozens of great weekly interviews we have lined up for you with leading designers, bestselling authors, activists, impact investors and entrepreneurs. We're trying to change our lives for the better in some meaningful way. So if you haven't done so already, please follow us on your favorite podcast player to make sure you don't miss them. And now let's jump right in with Ana Ferreira and Alex Muench from Doist.   TIMESTAMP CHAPTERS [3:11] Life During Covid [5:53] Helping the Community [7:40] Early Driving Forces [10:05] The Definition of a Designer [12:21] The Birth of a Designer [13:53] The Road to Doist [19:12] Supporting a Well-Lived Life [22:39] Synchronous vs Asynchronous Challenges [27:15] The Derivation of Twist From Slack [31:34] Redesigning Communication [36:19] Early Versions of Twist [37:53] Market Reactions and the Value of Async Communication [41:59] A Sermon for Designers   EPISODE LINKS Ana and Alex's Links

A. Derivation for Water Libarion from הסך נסך B. Authorship Rabbi Eliezer 1 from lulav Rabbi Yehuda ben Betera 2 from water libation Rabbi Akiva 6 from water libation Rabbi Yehoshua 8 from oral tradition 1. Who is the author of Mishnah Sukkah? R. Yehudah ben Betera R. Yehoshua 2. Who says we change over in musaf? R. Yehoshua R. Yehosua ben Betera C. No need to mention Dew and Wind D. The Best Wind and Rain Sponsored by Seth and Jennifer Haberman in Memory of Simon Haberman A”H

En este nuevo episodio realizo un repaso muy breve del shock index o índice de shock. Espero que les guste y sea de utilidad. Referencias: - Café Club del Conocimiento. Antonio Pérez Alonso y Susana Simo. Shock. - Lee YT, Bae BK, Cho YM, Park SC, Jeon CH, Huh U, Lee DS, Ko SH, Ryu DM, Wang IJ. Reverse shock index multiplied by Glasgow coma scale as a predictor of massive transfusion in trauma. Am J Emerg Med. 2021 Aug;46:404-409. doi: 10.1016/j.ajem.2020.10.027. Epub 2020 Oct 20. PMID: 33143960. - Kimura, A., Tanaka, N. El índice de choque inverso multiplicado por la puntuación de la escala Coma de Glasgow (rSIG) es una medida simple con alta capacidad discriminante para el riesgo de mortalidad en pacientes traumatizados: un análisis del Banco de Datos de Trauma de Japón. Crit Care 22,87 (2018). https://doi.org/10.1186/s13054-018-2014-0 - El-Menyar A, Goyal P, Tilley E, Latifi R. The clinical utility of shock index to predict the need for blood transfusion and outcomes in trauma. J Surg Res. 2018 Jul;227:52-59. doi: 10.1016/j.jss.2018.02.013. Epub 2018 Mar 12. PMID: 29804862. - Marín Barboza, L., & Muñoz, R. (2020). Índice de choque. Revista Ciencia Y Salud Integrando Conocimientos, 4(4), Pág. 31–38. https://doi.org/10.34192/cienciaysalud.v4i4.168 - NAEMT. Manual proveedor PHTLS. Ed. 9. 2018. - Olaussen A, Blackburn T, Mitra B, Fitzgerald M. Review article: Shock Index for prediction of critical bleeding post-trauma: A systematic review: Shock Index for Critical Bleeding. Emerg Med Australas. junio de 2014;26(3):223-8. - Mitra B, Fitzgerald M, Chan J. The utility of a shock index≥1 as an indication for pre-hospital oxygen carrier administration in major trauma. Injury. enero de 2014;45(1):61-5. - Al Jalbout N, Balhara KS, Hamade B, Hsieh Y-H, Kelen GD, Bayram JD. Shock index as a predictor of hospital admission and inpatient mortality in a US national database of emergency departments. Emerg Med J. mayo de 2019;36(5):293-7. - Edla S, Reisner AT, Liu J, Convertino VA, Carter R, Reifman J. In reply to “Utility of shock index calculation in hemorrhagic trauma”. Am J Emerg Med. julio de 2015;33(7):978-9. - Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, et al. The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding. Aliment Pharmacol Ther [Internet]. 23 de octubre de 2019 [citado 31 de octubre de 2019]; Disponible en: http://doi.wiley.com/10.1111/apt.15541 - Campos-Serra A, Montmany-Vioque S, Rebasa-Cladera P, Llaquet-Bayo H, Gràcia-Roman R, Colom-Gordillo A, et al. Aplicación del Shock Index como predictor de hemorragia en el paciente politraumático. Cir Esp. octubre de 2018;96(8):494-500. - Kristensen AKB, Holler JG, Hallas J, Lassen A, Shapiro NI. Is Shock Index a Valid Predictor of Mortality in Emergency Department Patients With Hypertension, Diabetes, High Age, or Receipt of β- or Calcium Channel Blockers? Ann Emerg Med. enero de 2016;67(1):106-113.e6. - Abe N, Miura T, Miyashita Y, Hashizume N, Ebisawa S, Motoki H, et al. Long-Term Prognostic Implications of the Admission Shock Index in Patients With Acute Myocardial Infarction Who Received Percutaneous Coronary Intervention. Angiology. abril de 2017;68(4):339-45. - Yu T, Tian C, Song J, He D, Sun Z, Sun Z. Derivation and Validation of Shock Index as a parameter for Predicting Long-term Prognosis in Patients with Acute Coronary Syndrome. Sci Rep. diciembre de 2017;7(1):11929.1.2.3.4.5.6.7.8.9. - Kobayashi A, Misumida N, Luger D, Kanei Y. Shock Index as a predictor for In-hospital mortality in patients with non-ST-segment elevation myocardial infarction. Cardiovasc Revasc Med. junio de 2016;17(4):225-8. - El-Menyar A, Sulaiman K, Almahmeed W, Al-Motarreb A, Asaad N, AlHabib KF, et al. Shock Index in Patients Presenting With Acute Heart Failure: A Multicenter Multinational Observational Study. Angiology. noviembre de 2019;70(10):938-46. - Middleton, Smith, Bedford, Neilly, Myint. Shock Index Predicts Outcome in Patients with Suspected Sepsis or Community-Acquired Pneumonia: A Systematic Review. J Clin Med. 31 de julio de 2019;8(8):1144. - Acker SN, Ross JT, Partrick DA, Tong S, Bensard DD. Pediatric specific shock index accurately identifies severely injured children. J Pediatr Surg. febrero de 2015;50(2):331-4. - Nordin A, Shi J, Wheeler K, Xiang H, Kenney B. Age-adjusted shock index: From injury to arrival. J Pediatr Surg. mayo de 2019;54(5):984-8. - Strutt J, Flood A, Kharbanda AB. Shock Index as a Predictor of Morbidity and Mortality in Pediatric Trauma Patients: Pediatr Emerg Care. febrero de 2019;35(2):132-7. - Hashmi A, Rhee P, Pandit V, Kulvatunyou N, Tang A, O’Keeffe T, et al. Shock Index Predicts Mortality in Geriatric Trauma Patients: An Analysis of The National Trauma Data Bank. J Surg Res. febrero de 2014;186(2):687. - Chung J-Y, Hsu C-C, Chen J-H, Chen W-L, Lin H-J, Guo H-R, et al. Shock index predicted mortality in geriatric patients with influenza in the emergency department. Am J Emerg Med. marzo de 2019;37(3):391-4. - Kuo SCH, Kuo P-J, Hsu S-Y, Rau C-S, Chen Y-C, Hsieh H-Y, et al. The use of the reverse shock index to identify high-risk trauma patients in addition to the criteria for trauma team activation: a cross-sectional study based on a trauma registry system. BMJ Open. junio de 2016;6(6): e011072. - Jiang L, Caputo ND, Chang BP. Respiratory adjusted shock index for identifying occult shock and level of Care in Sepsis Patients. Am J Emerg Med. marzo de 2019;37(3):506-9.10.11.12.13.14.15.16.17.18.19.38 - Laura Pariente Juste, Maylin Koo Gómez, Antonia Bonet Burguera, Raquel Reyes García, Lourdes Pérez García, Irene Macía Tejada Índices de shock prehospitalario y hospitalario como predictores de transfusión masiva en la atención inicial del paciente politraumático Emergencias 2021;33:29-34

What I'm really interested in, however, is the meaning behind the word abracadabra. We don't know the exact etymology for sure but I'm fascinated by two origin theories. Some scholars think it comes from an Aramaic phrase avra kehdabra, meaning “I will create as I speak”. Others think it's from the Chaldean abbada ke dabra, meaning “perish like the word”.  That's right, my friends. I know it took a minute to get here but today we are literally discussing the magic and power in words. This is something that I personally am very passionate about. Support the show (https://paypal.me/vibrantlifepodcast)