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Chad Tracy's decision to pull Sonny Gray after just 70 pitches sends the Red Sox into chaos. Gray had allowed only one run, yet Boston went to a struggling bullpen and watched the Yankees immediately take advantage. Evan Roberts, Tiki Barber and Shaun Morash rip the move and question whether Tracy has already lost his clubhouse. Gray makes his frustration impossible to ignore, saying he wanted to live or die with the moment before delivering an ominous “I don't know” when asked about returning to Boston. Wilson Contreras also appears unhappy with the organization's reliance on analytics. Plus, the crew dives into the suspicious substance spotted on Gray's neck and wonders how neither the Yankees nor the umpires caught it during the game.
LIVE from ILADS: Tick Boot Camp sits down with Dr. Somer DelSignore, DNP, BC-PNP, founder of Hudson Valley Integrative Health in Beacon, New York, for a wide-ranging conversation about pediatric Lyme disease, congenital tick-borne infections, autism spectrum symptoms, PANS/PANDAS, autoimmune encephalopathy, developmental delays, behavioral changes, and the importance of investigating potential biological contributors to neuroimmune dysfunction. Dr. DelSignore practices integrative pediatrics with a focus on children experiencing complex chronic illness and neuroimmune symptoms. Rather than stopping at a behavioral or developmental diagnosis, she describes a root-cause approach that asks a deeper question: What biological processes could be contributing to this child's symptoms? The conversation explores some challenging and evolving areas of medicine, including possible relationships among infections, inflammation, immune dysfunction, neurological development, and behavioral symptoms. Dr. DelSignore shares observations from her clinical practice and argues for more comprehensive biomedical evaluation of children with complex or atypical presentations. This interview was recorded live at the ILADS conference, so you may hear some of the energy and background activity of the event throughout the conversation. Looking Beyond a Pediatric Diagnosis Dr. DelSignore describes treating children who don't always fit neatly into one diagnostic category. Some arrive with: Autism spectrum diagnoses or symptoms Developmental delays Behavioral changes Cognitive difficulties Motor delays Speech and language delays PANS/PANDAS Autoimmune or neuroimmune symptoms Suspected congenital Lyme disease Other tick-borne infections A pattern she says sometimes catches parents' attention is an unexpected improvement when a child receives treatment for an unrelated infection. Parents may report that their child temporarily gains language, motor, behavioral, or other skills while taking an antibiotic, only to regress after treatment ends. For Dr. DelSignore, observations like these are clues that warrant further investigation rather than immediate conclusions. Root-Cause Medicine for Children Dr. DelSignore describes her work as a form of detective work. A diagnosis describes what clinicians are observing, but she wants to investigate why those symptoms are occurring. When a child presents with neurological, developmental, behavioral, or immune dysfunction, she evaluates possible contributors and works backward from the symptoms. That may involve extensive history-taking, laboratory evaluation, the child's medical history, environmental factors, immune function, infections, inflammation, genetics, and sometimes the parents' medical histories. Once potential contributors are identified, her goal is not only to address them but also to support the immune and neurological systems as the child progresses. Learn more about Dr. Somer DelSignore and Hudson Valley Integrative Health. Congenital Lyme & Tick-Borne Infections One of the most important subjects in this conversation is congenital or maternal-fetal transmission of tick-borne infections. Dr. DelSignore discusses evaluating both children and their parents when the child's presentation suggests that infection or immune dysfunction could have begun during pregnancy or early development. She specifically discusses Borrelia, Bartonella, and Babesia — the pathogens Tick Boot Camp often refers to as the Three B's — in the context of her clinical work. Dr. DelSignore also discusses another possibility: even when direct transmission isn't established in an individual case, maternal infection and inflammation during pregnancy could potentially influence fetal immune or neurological development. These are complex and evolving areas of research, and determining what occurred in an individual child requires careful clinical evaluation rather than assuming that every developmental or neuroimmune condition has an infectious cause. Why Family History Matters With very young patients, Dr. DelSignore says the parents' history can become especially important. She asks mothers questions such as: Were you exposed to ticks? Did you experience unexplained symptoms before or during pregnancy? Did you have unusual illnesses earlier in life? Did you struggle with immune dysfunction? Do you have autoimmune conditions? Were there infections or inflammatory problems during pregnancy? For an infant who cannot describe symptoms, family history may provide clues that aren't available from the child alone. Dr. DelSignore combines that history with clinical presentation and diagnostic testing when deciding what warrants further investigation. What Might Lyme Disease Look Like in a Young Child? Young children present a unique diagnostic challenge. They cannot necessarily explain that they are exhausted, experiencing pain, having temperature changes, or feeling neurologically different. Dr. DelSignore describes seeing infants with findings such as hypotonia — unusually low muscle tone — along with feeding and sleeping difficulties that extend beyond what would ordinarily be expected. As children grow, additional clues may emerge. Clinicians and parents can begin evaluating whether a child is: Sitting appropriately Crawling Developing speech Gaining words Building sentences Developing motor skills Interacting socially Meeting expected developmental milestones Dr. DelSignore emphasizes that none of these signs by themselves diagnose Lyme disease or another tick-borne infection. Instead, they may be reasons to investigate further when considered alongside medical history, exposures, physical findings, and other symptoms. Behavioral Symptoms in Toddlers & Children In toddlers and older children with tick-borne illness, Dr. DelSignore says the presentation can become heavily neurological or behavioral. She discusses symptoms including: Irritability Impulsivity Poor sleep Delayed speech Social difficulties Auditory sensitivity Visual sensitivity Anxiety Depression OCD-like behaviors Rage Fatigue Sweating Temperature dysregulation The difficulty is obvious: many of these symptoms overlap with other pediatric neurological, developmental, psychiatric, and medical conditions. A nonverbal child also may not be able to report fatigue, pain, headaches, sensory changes, or other physical symptoms. That overlap is one reason Dr. DelSignore argues against trying to identify tick-borne illness from behavior alone. Autism, Lyme Disease & an Important Distinction A substantial portion of this conversation explores autism and possible biological contributors to autism-spectrum presentations. This requires an important distinction. Autism is not synonymous with Lyme disease, and an autism diagnosis by itself does not establish the presence of a tick-borne infection. Dr. DelSignore's position is that some children diagnosed with autism or presenting with autism-like symptoms may also have infections, inflammation, autoimmune processes, or other biomedical issues that deserve investigation. She describes autism as a syndrome diagnosed from patterns of behavior and development rather than through a single definitive laboratory test. From her root-cause perspective, she therefore asks what potentially modifiable biological factors might coexist with or contribute to an individual child's presentation. This distinction is especially important because the scientific questions surrounding infection, immune activation, neurodevelopment, and autism remain complex and actively studied. Can Treating an Infection Change Developmental Symptoms? Dr. DelSignore shares clinical experiences in which she says children experienced substantial developmental and behavioral improvement after underlying infections and immune dysfunction were addressed. She discusses one case involving a nonverbal child with significant autism-spectrum symptoms whom she says tested positive for Borrelia, Bartonella, and Babesia in the context of suspected maternal transmission. Following treatment, she reports that the child progressed dramatically and was functioning much more typically by school age. This is a clinical case described by Dr. DelSignore, not evidence that tick-borne infections explain autism broadly or that antimicrobial treatment is an established autism treatment. What it illustrates is the central argument she makes throughout this episode: When a child's presentation is unusual or complex, clinicians should remain curious about potentially treatable medical contributors. The Neuroimmune Connection Dr. DelSignore encourages clinicians to think about some pediatric presentations through a neuroimmune lens. The nervous system and immune system don't operate independently. Infection can trigger immune activity and inflammation, and immune dysfunction can have neurological consequences. Dr. DelSignore discusses evaluating children for both infections and evidence of autoimmune activity when clinically appropriate. Rather than attempting to draw a clean line between a behavioral diagnosis and an infectious diagnosis, she looks at the entire clinical picture and asks what combination of processes could be affecting that individual child. PANS/PANDAS & Autoimmune Encephalopathy This same framework is relevant to Dr. DelSignore's work with PANS, PANDAS, and autoimmune encephalopathy. Children with these conditions can experience dramatic neuropsychiatric or behavioral changes associated with immune activation. Dr. DelSignore's clinical focus includes identifying possible infectious and inflammatory triggers and then addressing both the trigger and the downstream immune or neurological dysfunction. Her work therefore overlaps infectious disease, immunology, neurology, psychiatry, and developmental pediatrics rather than remaining confined to a single specialty. ILADS identifies Dr. DelSignore's areas of focus as neuroimmunology, autism spectrum disorder, PANS/PANDAS, and chronic/congenital Lyme disease. Why Comprehensive Evaluation Matters One of Dr. DelSignore's strongest messages is that children with complex developmental or behavioral presentations deserve a thorough medical evaluation. She says older children often reach her practice after seeing numerous providers while their symptoms have been characterized primarily as behavioral or psychiatric. By the time they arrive, some families have spent years searching for explanations. Dr. DelSignore advocates looking more broadly at potential contributors, including infection, immune dysfunction, inflammation, environmental exposures, genetics, nutrition, and other biological factors when clinically indicated. The goal isn't to assume every child has Lyme disease. It's to ask enough questions before deciding that nothing else is contributing to the child's symptoms. Psychiatric Symptoms Can Have Medical Contributors The conversation also examines the relationship between physical health and psychiatric symptoms. Dr. DelSignore describes situations in which she believes infection-driven immune activation and neuroinflammation may contribute to anxiety, depression, irritability, OCD-like behaviors, rage, and other neuropsychiatric symptoms. She argues for investigating potential biological contributors rather than automatically treating every behavioral presentation as an isolated psychiatric problem. At the same time, the conversation acknowledges that psychiatric medications can be appropriate and important for some patients. The larger message is individualized care: evaluate the whole child and determine what combination of supports that particular patient needs. No Single Cause of Autism Near the end of the interview, the conversation turns to claims about acetaminophen/Tylenol use during pregnancy and autism. Dr. DelSignore rejects the idea that there is a simple, single explanation for autism. She describes autism as potentially involving many interacting factors and argues that research findings about individual exposures need to be interpreted in context rather than reduced to a headline claiming one substance "causes autism." Her broader point aligns with the philosophy she describes throughout the interview: There is no simple answer for a complex biological system. Instead, she looks for what she describes as a "stacking" of contributing factors that may differ substantially from one child to another. Can Women with Lyme Disease Have Children? The interview closes on a question that creates tremendous fear for many young women diagnosed with Lyme disease: Can I safely have a child? Tick Boot Camp raises the importance of helping women understand congenital Lyme disease, pregnancy, treatment before conception, care during pregnancy, and what parents and clinicians should consider after birth. Dr. DelSignore agrees that these questions deserve much deeper discussion. The existence of congenital transmission concerns should not be interpreted as meaning that someone with Lyme disease cannot have a healthy pregnancy or healthy child. Instead, it reinforces the value of working with knowledgeable healthcare professionals to develop an individualized plan before and during pregnancy. For a deeper Tick Boot Camp conversation with Dr. DelSignore, listen to Pediatric Lyme, Autism Regression, PANS/PANDAS & Root-Cause Healing. About Dr. Somer DelSignore Dr. Somer DelSignore, DNP, BC-PNP is a board-certified pediatric provider and founder of Hudson Valley Integrative Health in Beacon, New York. Her clinical work focuses on complex chronic illness in children, including neuroimmunology, PANS/PANDAS, autoimmune encephalopathy, autism-spectrum presentations, Lyme disease, and congenital tick-borne illness. She completed graduate and doctoral education at the University of Pennsylvania and SUNY Upstate Medical University and has pursued advanced mentorship and training in integrative medicine, Lyme disease, PANS, and autism. She developed the R.E.S.E.T. Protocol, a root-cause framework for addressing immune dysfunction. Dr. DelSignore is also a member of the ILADS Pediatric Committee. Key Topics in This Episode Pediatric Lyme disease, congenital Lyme disease, Dr. Somer DelSignore, autism and Lyme disease, autism spectrum disorder, PANS, PANDAS, autoimmune encephalopathy, neuroimmune dysfunction, neuroinflammation, Borrelia, Bartonella, Babesia, Three B's, developmental delays, speech delay, hypotonia, behavioral symptoms, pediatric tick-borne disease, maternal-fetal transmission, congenital tick-borne infections, root-cause medicine, integrative pediatrics, biomedical evaluation, immune dysfunction, psychiatric symptoms, pregnancy and Lyme disease, and pediatric Lyme testing. About This LIVE from ILADS Interview This conversation was recorded in person at the 2025 International Lyme and Associated Diseases Society Annual Scientific Conference, From Terrain to Treatment: Advances in Vector-Borne Illness, held October 9–12, 2025, in San Antonio, Texas. Because these interviews were recorded live at the conference, they have a different feel from Tick Boot Camp's traditional long-form virtual and studio conversations — shorter, focused, and surrounded by the activity of one of the world's major gatherings of Lyme and tick-borne disease clinicians, researchers, advocates, and innovators. Dr. DelSignore was also a speaker at the conference, where ILADS highlighted her work in integrative pediatrics and personalized treatment for children. Explore all Tick Boot Camp LIVE from ILADS interviews. More from Tick Boot Camp Watch or listen to Tick Boot Camp's long-form interview with Dr. Somer DelSignore for a deeper exploration of pediatric Lyme disease, congenital infection, autism regression, PANS/PANDAS, and root-cause healing. Hear more conversations with Lyme disease doctors and healthcare professionals, or explore the Tick Boot Camp Podcast for hundreds of patient stories and interviews with doctors, researchers, advocates, and other voices throughout the Lyme disease community. Send us your feedback online: https://pinecast.com/feedback/tick-boot-camp/2f9253e9-955e-423b-ac71-2ec25d9c29e4
Agile does not have to undermine UX—but low maturity, rushed delivery, and “Agile in name only” often do. This week, Dr. Darren explores how UX maturity impacts our ability to excel in Agile and how UX professionals can thrive in such environments without compromising research, strategy, quality, or meaningful outcomes.#ux#podcasts#cxofmradio#cxofm#realuxtalk#worldofuxDon't forget to like, subscribe, and share!Bookmark the new World of UX website at https://www.theworldofux.com. Visit the UX Uncensored blog at https://uxuncensored.medium.com. Get your specialized UX merchandise at https://www.kaizentees.com.
The inability to have clarifying conversations, and how dysfunction can perpetuate dysfunction
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How can recognizing emotional abuse, rebuilding trust in yourself, and setting healthy boundaries help break harmful family patterns? Tune in for an inspiring discussion with Beverly Engel, LMFT, on her upcoming book Adult Children of Emotionally Abusive Families: Overcoming the Pain, Dysfunction, and Trauma of Growing up in a Toxic Family.Moments with Marianne Radio Show airs in the Southern California area on KMET1490AM & 98.1 FM, an ABC Talk News Radio Affiliate! https://www.kmet1490am.com Beverly Engel, LMFT is an internationally recognized psychotherapist and expert on the subject of trauma. She has written numerous books on the related subjects of abuse, shame and empowerment, including The Emotionally Abusive Relationship, Healing Your Emotional Self and It Wasn't Your Fault. She has a blog on Psychology Today entitled, “The Compassion Chronicles,” and her writing has been featured in publications including Oprah Magazine, Cosmopolitan, The Washington Post, The Chicago Tribune, and The Los Angeles Times. https://beverlyengel.com Pre-Order on Amazon: https://a.co/d/0j3iU3zX Discover inspiring conversations with today's leading authors, celebrities, thought leaders, and change makers. To learn more about the Moments with Marianne Radio Show, explore guest interview opportunities, connect with Marianne, and follow her on social media, visit https://www.mariannepestana.comExplore the Moments with Marianne Book Club and find your next great read: https://www.mariannepestana.com/book-club/Listen to the Moments with Marianne Radio Show on KMET 1490AM & 98.1FM, an ABC News Radio Affiliate, weekdays at 8:06 AM PT / 11:06 AM ET and Sundays at 10:06 AM PT / 1:06 PM ET. Learn more at: https://www.kmet1490am.com/moments-with-marianne
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Understanding dysfunctional patterning from first inception, mirroring aspects of our current struggles both through beliefs and emotional charge, that holds back the soul from evolving its current physical experience.
Dr. Darren Hood launches Milestones in Dysfunction, a new sub-series within Harsh Realities of UX Maturity. In this episode, he examines how misdefining and misappropriating UX—particularly reducing it to “UX/UI” or visual polish—has weakened the discipline's scientific, strategic, and business-centered foundation.#ux#podcasts#cxofmradio#cxofm#realuxtalk#worldofux#worldouxDon't forget to like, subscribe, and share!Bookmark the new World of UX website at https://www.theworldofux.com. Visit the UX Uncensored blog at https://uxuncensored.medium.com. Get your specialized UX merchandise at https://www.kaizentees.com.
The Vince Coakley Radio Program | Wednesday, September 23rd, 2026. Hour 1 Segment 1 – Live from Little Heroes Blood Drive Segment 2 – CMS cuts ties with Dr. Crystal Hill after 5-4 vote by CMS board Segment 3 – WBT text line talks CMS saga after firing of Crystal Hill Segment 4 – Tiawana Brown sentenced to 10 months in prison for wire fraud conviction Hour 2 Segment 1 – Wellness Wednesday Segment 2 – WBT text line with Vince Segment 3 – Consumer behavior indicates "Americans are struggling" Segment 4 – Nolan Welles case See omnystudio.com/listener for privacy information.
Mike Florio discusses Todd Monken, Browns dysfunction, and the importance of avoiding past football issues on Baskin & Phelps.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive into thyroid health and explains why diagnosing and managing thyroid dysfunction is unusually complex. He begins with the basic biology of the thyroid gland and three commonly measured hormones—free T4, free T3, and TSH. He explains how T4 is converted to the active hormone T3 and the important functions T3 performs throughout the body. He also explains what reverse T3 is and when it may be useful to measure it. Peter then breaks down thyroid blood tests and their limitations and provides a practical framework for evaluating suspected thyroid dysfunction. He explains why symptoms alone are insufficient for diagnosis and reviews the criteria for diagnosing hypothyroidism, along with conditions that can mimic it. He also explores how hypothyroidism can be both underdiagnosed and overtreated and how to navigate subclinical hypothyroidism. Peter discusses treatment with T4 and T3, including why some patients continue to experience symptoms despite standard T4 replacement. He also explains how thyroid medications should be taken to optimize absorption. Additional topics include Hashimoto's disease, thyroid considerations during pregnancy, hyperthyroidism, the risks of excess iodine, and supplements marketed to support thyroid function. Finally, Peter offers guidance for patients who continue to feel unwell despite apparently normal thyroid tests. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #89 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Why thyroid management is unusually complex and what the thyroid does [2:00]; Why symptoms are insufficient for diagnosis and the risks of underdiagnosis and overtreatment [9:00]; Regulation of the thyroid axis and conversion of T4 to T3 [13:30]; Reverse T3 and the metabolic effects of T3 [20:00]; Thyroid blood tests, assay limitations, and who should be tested [22:45]; Causes and mimics of hypothyroidism and the criteria for diagnosis [29:00]; Navigating subclinical hypothyroidism [34:30]; Treating hypothyroidism with T4 and T3 [37:00]; Hashimoto's disease, pregnancy, and associated autoimmune risks [42:45]; Proper timing and administration of thyroid medication [43:45]; Causes, symptoms, diagnosis, and treatment of hyperthyroidism [45:15]; Iodine excess, the risks of thyroid-support supplements, and evidence for dietary interventions [53:45]; A practical framework for evaluating and treating patients who suspect thyroid dysfunction [59:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Maybe there is such a thing as reckless breeding. Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us Fan MailEvery single convo I've ever had with a wife has had this ONE thing in common even though nearly every situation was unique. And it's this key that unlocks what God wants to do in and through your marriage. Support the showChelsey Holm | the Wife Coach "I lead Christian wives to become TENDER, TENACIOUS & TAKING BACK TERRITORY the enemy has stolen. To live by God's design in marriage through right order, repentance & radical obedience.First step? Grab the 30 Day Guide: War Room RESET: daily action to regulate, realign, and reconnect.
► Vote for ACSOM at the Football Content Awards: https://footballcontentawards.com/voting/ ► Help us to release the George Connelly documentary: https://www.crowdfunder.co.uk/p/george-connelly-celtic-film
In a return to the Harsh Realities of UX Maturity series, Dr. Darren offers a historical look at key UX trends, tying them to shifts in UX maturity across the discipline. Check out this episode in light of when you entered the discipline, how it has "changed," and why.#ux#podcasts#cxofmradio#cxofm#realuxtalk#worldofux#worldouxDon't forget to like, subscribe, and share!Bookmark the new World of UX website at https://www.theworldofux.com. Visit the UX Uncensored blog at https://uxuncensored.medium.com. Get your specialized UX merchandise at https://www.kaizentees.com.
Anthony Lima replays his own breakdown of Deshaun Watson's first-half interception, comparing it to coaching an 11-year-old, which sends Ken Carman into a rant about how the blowout loss insults fans' intelligence and cements his refusal to ever pick the Browns again this season. A wave of callers follows, questioning whether Todd Monken's vague QB competition and non-answers on a potential in-season change signal Cleveland is repeating the Stefanski era's dysfunction. The segment wraps with a news recap: Watson's final stat line, Myles Garrett's four-week absence after knee surgery, and the Guardians pulling within a half-game of first place.
► Vote for ACSOM at the Football Content Awards: https://footballcontentawards.com/voting/ ► Help us to release the George Connelly documentary: https://www.crowdfunder.co.uk/p/george-connelly-celtic-film
Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure patients. Steffen-Sebastian explains, "So what we would consider resistance arteries is anything between the capillary level, which would be 10 micrometers, up to, let's say, a few hundred micrometers. And 300 micrometers is the thickness of a blonde hair. That's kind of what we're talking about here. And everything else, and what I talk about in function is what I said before: they can change their diameter. They can open up or close, which large arteries can not do. They are stiff as a garden hose. They are conduits with arteries. They are made to conduct blood at the lowest resistance possible, whereas the small resistance arteries are made to change resistance and regulate flow and pressure." "As I said, these small resistance arteries and capillaries are everywhere. Every organ has them. And if you compromise the function of those resistance arteries, you compromise blood flow to the capillaries, which actually means that the capillaries don't get enough oxygen. They cannot transport CO2 away from the tissues. They don't get enough nutrients and so on, which then leads to functional damage, which is number one." "And if it persists, if the problem persists, it can also lead to structural damage, which we can actually see. You mentioned the heart. The heart can deal with it, and also the brain can deal with reductions in that flow to a certain extent. But if the reduction in blood flow exceeds a certain limit, you get structural damage. And we see that structural damage. And we call them infarctions in the heart, but also in the brain, which is a stroke." #QanatPharma #VascularBiology #MicrovascularHealth #DrugDiscovery #HeartFailure #CognitiveImpairment #BiotechInnovation #PrecisionMedicine #AIinDrugDiscovery#Microvascular #Neurology #DrugRepurposing #Cardiology #MedicalResearch #ClinicalTrials #Hypertension qanatpharma.com Download the transcript here
Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure patients. Steffen-Sebastian explains, "So what we would consider resistance arteries is anything between the capillary level, which would be 10 micrometers, up to, let's say, a few hundred micrometers. And 300 micrometers is the thickness of a blonde hair. That's kind of what we're talking about here. And everything else, and what I talk about in function is what I said before: they can change their diameter. They can open up or close, which large arteries can not do. They are stiff as a garden hose. They are conduits with arteries. They are made to conduct blood at the lowest resistance possible, whereas the small resistance arteries are made to change resistance and regulate flow and pressure." "As I said, these small resistance arteries and capillaries are everywhere. Every organ has them. And if you compromise the function of those resistance arteries, you compromise blood flow to the capillaries, which actually means that the capillaries don't get enough oxygen. They cannot transport CO2 away from the tissues. They don't get enough nutrients and so on, which then leads to functional damage, which is number one." "And if it persists, if the problem persists, it can also lead to structural damage, which we can actually see. You mentioned the heart. The heart can deal with it, and also the brain can deal with reductions in that flow to a certain extent. But if the reduction in blood flow exceeds a certain limit, you get structural damage. And we see that structural damage. And we call them infarctions in the heart, but also in the brain, which is a stroke." #QanatPharma #VascularBiology #MicrovascularHealth #DrugDiscovery #HeartFailure #CognitiveImpairment #BiotechInnovation #PrecisionMedicine #AIinDrugDiscovery#Microvascular #Neurology #DrugRepurposing #Cardiology #MedicalResearch #ClinicalTrials #Hypertension qanatpharma.com Listen to the podcast here
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How abuse shapes our relationships
The blood–brain barrier is a highly specialised interface that regulates the movement of cells, molecules and nutrients between the circulation and the central nervous system. But what happens when this critical barrier becomes dysfunctional in multiple sclerosis? In this episode of the ECTRIMS Podcast, host Brett Drummond speaks with Prof. Elga de Vries of Amsterdam UMC and MS Center Amsterdam about the evolving science of blood–brain barrier dysfunction in MS. They explore how the blood–brain barrier functions in health, how its disruption relates to immune cell infiltration and inflammatory disease activity, and why research increasingly suggests these changes may remain relevant across different stages of MS. The conversation also looks at innovative blood–brain barrier-on-a-chip models, how existing MS treatments interact with the barrier, and emerging approaches designed to transport therapies more effectively into the CNS. Finally, they consider an intriguing future direction: could strengthening the blood–brain barrier itself become part of the therapeutic strategy for MS? This podcast episode is supported by an educational grant from Alexion, AstraZeneca Rare Diseases, Bristol Myers Squibb, Roche, Sanofi, and UCB.
Send us Fan Mail“I did the best I could” can sound like an explanation, but when it is used to avoid accountability for real harm, it can leave adult children questioning their own reality for years.In this episode, we unpack why “I did the best I could” is not always a viable excuse, especially when a parent refuses to acknowledge, repair, or change harmful patterns. Emilia and Bianca explore how entire family systems can reinforce denial, why the sibling who speaks up is often labeled the problem, and what happens when maintaining a relationship requires you to repeatedly betray your own truth. They also discuss what future parents can do differently by practicing accountability, apology, emotional attunement, and the willingness to keep bettering their best.Here's a related episode that builds on today's conversation: #529 | The Truth About Wanting Them to Apologize - https://podcasts.apple.com/us/podcast/529-the-truth-about-wanting-them-to-apologize/id1511831621?i=1000781645317 Learn more about:
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This video discusses Jason Arday's lineage and the circumstances surrounding his death. It also examines workplace favoritism, arguing that racial preferences can create unfair advantages, and suggests that giving people opportunities only to later take them away can be a form of psychological manipulation. The video compares corporations to exclusive clubs, discusses how the press can use people to influence public opinion, and ultimately critiques what it describes as the negative expansion of DEI into society. Full episode on https://www.patreon.com/cw/TheexpresstruthshowLet me know your thoughts in the comments section down below...SPONSORED BY https://www.instagram.com/supremeoftheuk/?hl=enORDER https://www.thehatman.com/product-category/clothing/supreme-of-the-uk/?fbclid=PAZXh0bgNhZW0CMTEAAacevzCe-rFKZU3iPH0qYqxU7f__v0yznTpLkO6k9u-gHIxI4oQ9JfyhlttATQ_aem_NJT_3YtGSSu7wm6TraEYJghttps://www.instagram.com/cfr_news/https://rumble.com/user/CFRNetworkhttps://x.com/CFRNetwork_https://twitter.com/CFRNetwork__
What happens when we start treating normal human experiences as symptoms of a mental disorder?In this episode of the Psyched to Practice Podcast, Paul Wagner and Dr. Ray Christner take a closer look at the line between normal distress and clinical pathology. They discuss how referral bias, self-diagnosis, rating scales, symptom matching, and even our own clinical expectations can lead us to see a diagnosis before we fully understand the person sitting in front of us.They also explore why context, culture, proportionality, persistence, and functional impairment matter when deciding whether a reaction is clinically significant. From grief and anxiety to ADHD, OCD, sleep problems, food preferences, and passive suicidal thoughts, the conversation looks at why a symptom alone does not tell the whole story.Most importantly, the episode asks a difficult question for clinicians: What if our attempts to help can sometimes reinforce the idea that normal emotions are problems that need to be eliminated?Mental health is not about never feeling sad, anxious, angry, or uncomfortable. It is about developing the capacity to experience those emotions without becoming controlled by them.For clinicians, this episode offers a reminder to slow down, stay curious, and understand the experience before deciding what it means.Brightminds AdPAR Ad This episode is brought to you by PAR.Explore the AI Report Writer here:https://www.parinc.com/product/ai-report-writer?utm_campaign=38111624-Psyched%20to%20Practice%202026&utm_source=P2P%20Podcast&utm_medium=Related%20PodcastsLearn more about the RIAS-2 NU here:https://www.parinc.com/product/groups/rias-rist-assessments?utm_campaign=38111624-Psyched%20to%20Practice%202026&utm_source=P2P%20Podcast&utm_medium=Related%20PodcastsTo hear more and stay up to date with Paul Wagner, MS, LPC and Ray Christner, Psy.D., NCSP, ABPP visit our website at: http://www.psychedtopractice.com “Be well, and stay psyched"
Rog and Rory are back to break down all of the Premier League action from Matchweek 2, including Cole Palmer and Chelsea firing on all cylinders under Xabi Alonso—but just how concerning is their leaky defense with their showdown against Arsenal looming next week? Meanwhile, Liverpool's situation remains increasingly muddled after another draw, this time against Nottingham Forest. Does the dysfunction stem from Andoni Iraola, the system, the players, ownership, or all of the above? Plus, Rayan Cherki and Bruno Fernandes take their wizardry to another level, while Tottenham welcome fresh faces only to endure the same misery. Plus, Rog and Rory unveil their latest "Fan Mood Rankings" across the Premier League.Check out the full interview with Bruno Fernandes here: https://mibcourage.co/3V5mwwsHear more from Cole Palmer and his return to form here: https://mibcourage.co/3V40DO8Watch the Dominic Calvert-Lewin interview here: https://mibcourage.co/4iDWUAzChapters00:00:00 - Liverpool vs. Nottingham Forest reactions00:08:42 - Pressure on Florian Wirtz00:12:20 - The transfers Liverpool still need00:19:15 - Chelsea vs. Brighton Reactions00:26:30 - Crystal Palace vs. Manchester City Reactions00:39:05 - Manchester United vs. Ipswich Town Reactions00:47:53 - Tottenham vs. Newcastle Reactions01:01:23 - Coventry vs. Hull Reactions01:04:20 - Leeds vs. Brentford Reactions01:06:06 - Sunderland vs. Fulham Reactions01:08:24 - Bournemouth vs. Everton Reactions01:16:52 - Happiest Fans? Saddest Fans?01:19:43 - Fan Letter: Maresca and GuardiolaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
She says that the real reasons behind the dysfunction in our schools are hidden beneath layers of carefully crafted propaganda and a climate of fear, perpetuated by school boards across the nation. Their covert tactic—abusing teachers to silence the truth—ensures that administrations, not the will of the people, remain in control. Teacher abuse is not only wrong and harmful, but it is also the main barrier to meaningful reform. By silencing those with firsthand knowledge, it allows those in power to mislead parents and the public.As a result, our schools often serve political agendas rather than the needs of society. School board elections are manipulated by self-serving administrations, and few people are aware of this because intimidated teachers are forced to comply without question.The following site is designed to be a resource for the public, providing information to uncover the truth about our schools and to challenge the widespread misinformation. https://endteacherabuse.org/index.html http://www.yourlotandparcel.orgSupport the show
God is able to work through the dysfunction of our homes.
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-- On the Show: -- Donald Trump is framing the midterms around himself, helping Democratic turnout and worrying Republicans who wanted local focus -- White House Press Secretary Karoline Leavitt is leaving without a designated replacement, rotating officials through briefings instead -- The Trump administration threatens to demolish the Kennedy Center after a court blocked adding Trump's name to the building -- Agriculture Secretary Brooke Rollins blamed high beef prices on a Biden war on cattle while withholding import country details -- White House aide Natalie Harp gained top-level access to Donald Trump while operating over a year without a security clearance -- Treasury Secretary Scott Bessent appeared breathless on TV, comparing Iran sanctions to D-Day and asking Iranian troops to disarm -- The Friday Feedback segment -- On the Bonus Show: Twenty-four hours of madness on Donald Trump's Truth Social page, and much more... ⚠️ Ground News: Get 40% OFF their unlimited access Vantage plan at https://ground.news/pakman
Can a company really put people first and still build a thriving workplace culture? On A New Direction with Coach Jay Izso, my guest Josh Block says yes — and he’s got fifteen years of proof. Who Is Josh Block? Josh Block spent fifteen years leading Block Imaging, growing the team from fifty people to more than four hundred, and revenue from thirty million dollars to two hundred fifteen million. He didn’t get there by squeezing more out of people — he got there by building a workplace culture rooted in trust. He went on to found Cube Mobile Imaging, expanding access to medical imaging for patients across the country, and today serves as Executive Advisor at Block Imaging. He’s also the author of the new book People Matter @Work. Josh works with executives navigating growth, brand-new managers who got the title without the training, and teams stuck in fear and disengagement — helping them reshape their workplace culture around trust, ownership, and generosity instead of pressure. Why Workplace Culture Starts With “We,” Not “Me” At the center of People Matter @Work is a simple but demanding idea: the biggest thing standing between a team and real performance often isn’t strategy, budget, or talent — it’s a leader running everything through “me.” Josh’s framework is built to shift workplace culture from isolation to ownership, and from pressure to possibility. If leadership has ever felt heavier the more responsibility you took on, this is the conversation for you. 3 Shifts That Build a Stronger Workplace Culture Josh breaks it down into three practices any leader can start using right away to strengthen their workplace culture: Lead together, not alone. Shared ownership — not hoarded decisions — is the backbone of a healthy workplace culture. Make decisions with intention. Thoughtful choices beat leading on autopilot, and they signal the kind of workplace culture you’re building. Practice transparency. Managing perception wears leaders out; honesty is what makes a workplace culture people actually trust. Whether you’re an executive navigating change, a manager who wasn’t quite ready for the promotion, or leading a team stuck in disengagement, these three shifts are the blueprint for a workplace culture where people — and performance — actually thrive. Listen to the Full Conversation Josh’s book is a playbook for building the kind of workplace culture where trust, accountability, and generosity aren’t posters on a wall — they’re how the place actually runs. Catch the full conversation with Josh Block on A New Direction with Coach Jay Izso, live and on the podcast, and get a new direction on what it actually means to lead. Josh Block’s book, “People Matter at Work: Fostering a Culture Where Team Members Thrive and Everyone Wins” is an outstanding book. If you are a fan of “The 5 Dysfunctions of a Team” by Lencioni then you are going to love this book! It takes a deeper look at how we will can truly build a team that builds trust and makes you organization and business more profitable. We have all heard the saying, “culture eats strategy for breakfast” well Josh Block has the proof as he takes his company to a higher stratosphere financially through a powerful workplace culture shift. And how does he do that? By sharing the principles of People Matter @Work. Josh literally takes us through his step of becoming a 20 something President of an already successful company and makes it even better. He recognizes during his own humbling experience there are 3 T’s, Working Together, making Thoughtful Decisions that affect his people, and being Transparent, helps his entire workforce become safe, seen, and successful. And the result is people take ownership of the company to want to see it succeed and in turn makes it tremendously profitable. It may sound like a risk to the average CEO, but as Josh points out the real risk was by not doing the work to make his entire team a integral part of the business. This book is for both the current leader and the aspiring leader. And he not only has proved, he gives you the tools and the mindset to create it for your business as well. Really enjoyed every page of the book. I highly recommend it. Get your copy of People Matter @Work by clicking here! Please Thank The Sponsors of A New Direction by LIKING and Following their pages: Linda Craft Team, REALTORS no matter where you live in the world, Linda Craft and her team can help you find the best professional in your area to help you sell or buy your next home. While most real estate professionals belong to a nationally affiliated company where they are obligated to use the people in their company's network. Linda Craft Team are privately owned and operated. That means they can find the absolute best professional from ANY company to ensure you get the best service. Located in the Raleigh Research Triangle Park of North Carolina…they are indeed legendary when it comes to service. Learn more by going to Linda Craft & Team, REALTORS www.LindaCraft.com Hey…do me a favor and please tell your friends to subscribe to A New Direction on their favorite podcast platform and give us a 5 star rating we are so grateful when you do! ABOUT YOUR HOST Meet Jay Izso Executive Performance Coach | Host of A New Direction Every week on A New Direction, I sit down with CEOs, founders, and the researchers behind the science of leadership performance. The conversations go deep. We talk about the decisions that built companies, the mistakes that nearly destroyed them, and the personal breakthroughs that changed everything. But here's what most people don't know about me: the show is an extension of the work I do every day with executives behind closed doors. Who I Am I'm an Executive Performance Coach. I work with CEOs and founders of $5M-$50M companies who have hit a wall they can't explain. The marketing looks fine. The team is capable. The market is there. But the business won't move. The problem, almost every time, is the person running it. I find the personal behavioral patterns that are driving the business dysfunction. Then I help the CEO disrupt those patterns so the company can grow. That's it. No motivational platitudes. No vision boards. Diagnostics, intervention, results. Where This Comes From My approach comes from two places most coaches never set foot in. The farm. I grew up as a farmhand in Ithaca, Nebraska—population 100. I started working at nine years old. By the time I left for college, I'd spent a decade learning that you can't cheat the harvest, pain is part of the job, and the work has to get done whether you feel like it or not. I was fourteen the first time I had to castrate boars. Nobody was going to do it for me. That lesson never left: sometimes you have to do things afraid. The forensic psychology unit. In graduate school at Washington State University, I trained under Dr. Thomas Brigham—co-author of the Handbook of Applied Behavior Analysis—in a human behavior lab focused on real-world problems. I then served in a Clinical Psych II role at Eastern State Hospital in Medical Lake, Washington, a forensic setting where I conducted psychological evaluations of individuals charged with the most serious criminal offenses. Sixteen months assessing human behavior at its most extreme taught me how to cut through defenses, identify what's really driving someone's decisions, and see what they can't see in themselves.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive into the liver and its central role in metabolic health. He explains why the liver can serve as a "canary in the coal mine" for metabolic dysfunction and explores how insulin resistance, visceral fat, alcohol consumption, genetics, and hormones contribute to liver disease, along with how increasing muscle mass can benefit liver health. Peter provides a framework for understanding the progression of liver disease, highlighting which stages are reversible and why early detection matters. He explains why normal liver enzymes can provide false reassurance, which labs he uses to assess liver health, and the tools available for detecting fibrosis and more advanced disease. Peter then breaks down the interventions that can meaningfully improve liver health once risk or disease is identified, ranging from diet and exercise to GLP-1–based therapies and other medications. Finally, he examines popular claims around liver "detoxification" and supplements, separating what is supported by evidence from what is unlikely to meaningfully improve liver health. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #88 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Why the liver is the "canary in the coal mine" for metabolic dysfunction, and an overview of what the liver does [2:00]; The relationship between the liver and blood sugar control [6:30]; A framework for understanding how metabolic disease affects the liver [9:15]; Chronic caloric surplus and insulin resistance as drivers of liver disease [11:00]; Liver diseases that result from metabolic dysfunction and the difference between steatosis and fibrosis [15:15]; How visceral fat affects liver health [20:00]; The importance of lifestyle interventions for liver and metabolic health: resistance training, not drinking calories, and the impact of fructose [22:00]; Why alcohol-associated liver disease is more common than we give it credit for [26:30]; Genetic and hormonal risks for liver disease [31:45]; Labs that objectively measure liver health and the FIB-4 score [35:30]; FibroScan: non-invasive imaging of the liver [44:30]; The resiliency of the liver: an organ that can heal itself [47:00]; Fibrosis staging and its impact on mortality and cancer risk [49:15]; Interventions for someone with MASLD: weight loss and GLP-1s [52:00]; Other medications used to treat metabolic liver disease [57:00]; The role of exercise in treating metabolic liver disease: caloric deficit and building muscle [59:45]; The myth of liver detoxes and cleanses, and a few supplements that may benefit the liver [1:01:15]; A practical summary: how to assess your risk and the levers that reverse the disease [1:08:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Deshaun Watson's response to being booed sends Evan Roberts off on the Browns, with Evan arguing Cleveland should have cut him and declaring the franchise even more dysfunctional than the Jets. Shaun Morash is in for Tiki Barber alongside Evan Roberts and pushes back, arguing some of the boos are fueled by fans wanting Sanders at quarterback. The debate quickly turns into a heated argument over Watson's performance, contract, and whether Cleveland should still be giving him another chance. The conversation also hits George Lombard Jr.'s huge expectations with the Yankees, Francisco Alvarez's struggles with the Mets, Shaun's absurd birthday-text feud with Tommy Lugauer, and Evan's new “Big Blue Tent” nickname for Jaxson Dart after another trip to the medical tent.
Send us Fan MailA term newborn looks fine on mom's chest, then crashes within minutes. By the time transport arrives, there's a pH of 6.9, a lactate over 10, and a baby already intubated and on surfactant. Is this pulmonary hypertension, congenital heart disease, or something else entirely? In this episode of From the Heart, It's Complicated, Dr. Adrianne Bischoff and Dr. Nim Goldshtrom work through a real, complex neonatal cardiac case in real time — the kind of case that keeps neonatologists up at night. They break down how to clinically differentiate PPHN from congenital heart disease with limited data, why epinephrine's response mattered more than the blood pressure number, how therapeutic hypothermia can unmask cardiac dysfunction, and why "blue is always better than gray" when managing a shunt-dependent circulation. Along the way: real literature, real physiology, and the reasoning behind decisions made under pressure, with a surprise diagnosis at the end. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Disclaimer: this podcast & article is educational, not medical advice. Talk to your doctor before changing your diet, exercise routine, or any treatment plan, especially if you're pregnant, nursing, or managing a chronic condition. The Thrive 120 Show reflects my clinical perspective — it isn't a substitute for individualized care.TLDR“Eat less, exercise more” assumes your metabolism is fundamentally intact — that it's a math problem. It's not. It's a biology problem, and biology has a hierarchy: upstream causes and downstream symptoms. Most conventional advice treats the symptoms.I organize the four real drivers of metabolic breakdown into a framework I call MESS²:* M — Muscle loss. Your metabolic engine. Crash dieting shrinks it further.* E — Endocrine disruption. Your control panel — insulin, thyroid, cortisol.* S — Sun exposure. The free, daily signal almost everyone is missing.* S² — Sleep, Stress, and Systemic inflammation. The silent wreckers that undo the other three.Diet and exercise aren't wrong — they're just in the wrong position in the sequence. Fix the foundation first, and they finally start working the way they're supposed to.If you want help figuring out where your own weak link is, check the show notes below for the Thrive 120 programs and the Metabolic Blueprint Session Your metabolism isn't a math problemYou go in for a visit. Labs show your weight creeping up, your blood sugar drifting higher, your energy in the tank. And you hear the familiar line: eat less, cut calories, exercise more.That advice isn't malicious — it comes from a good place. But it assumes your metabolism is fundamentally intact. That it's calories in, calories out, done.Here's the problem: what if the engine itself is damaged? What if the control panel is sending the wrong signals? Adding intense exercise on top of a body that's already inflamed and hormonally dysregulated isn't a fix — it's closer to pouring gasoline on a fire.Think about it the way you'd think about a car. If the engine light comes on and the car starts making a bad noise, you don't respond by pouring in more premium gas. You find out what's wrong with the engine first. Your body deserves the same order of operations.Left alone, your body doesn't just sit still — muscle drifts downward, hormonal signaling drifts off-schedule, inflammation creeps upward. None of that is a willpower problem. It's biology, and biology has an upstream and a downstream. Most people — and most conventional approaches — spend their time treating the downstream symptoms. Below is the upstream map.THRIVE 120 Substack with TriplePlayDoc is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.The MESS² FrameworkM — Muscle: your metabolic engineMuscle is metabolically expensive. Your body burns calories just to maintain it, even while you're sitting on the couch doing nothing. The more muscle you carry, the higher your resting metabolic rate; the less you carry, the fewer calories your body needs — and the easier it becomes to store fat.After about age 30, you naturally lose muscle mass every decade — commonly cited figures put it in the 3–8% per decade range, accelerating further after roughly age 60 to 70.¹ ² ³ This gradual process is called sarcopenia, and because it happens slowly, most people don't notice until it's already reshaped their metabolic baseline.Here's where it gets worse: when most people try to “fix” their metabolism, they reach for a calorie-restricted diet. Yes, the scale moves. But a meaningful portion of that loss isn't fat — it's muscle. You've made the engine smaller and lowered your metabolic floor. Then you return to normal eating (because restriction isn't sustainable long-term), and your body — now running a smaller engine — needs fewer calories than it did before. The result is the yo-yo cycle, and each round tends to leave you carrying a little more than the last time.If that pattern sounds familiar, it's not a willpower problem. It's a muscle problem, and muscle problems have muscle solutions: protecting and building lean tissue before you fixate on how much you're eating.E — Endocrine disruption: your control panelIf muscle is the engine, your hormones are the control panel. When the control panel sends the wrong signals, it doesn't matter how good the engine is underneath — nothing runs right. Three hormones do most of the damage:Insulin. Insulin's normal job is to move glucose out of your bloodstream and into your cells. When cells are bombarded with insulin repeatedly — from a diet high in refined carbohydrates and sugar, chronic stress, poor sleep, or excess artificial light exposure — they start tuning it out. That's insulin resistance. Blood sugar stays elevated, your body compensates by producing even more insulin, and because insulin is a storage hormone, chronically elevated insulin locks you out of fat-burning mode. Fat oxidation requires insulin to be low — it's not optional.Thyroid. Your thyroid sets the pace for how fast or slow every cell in your body runs. The standard screening test — TSH (thyroid-stimulating hormone) — is just a signal sent from the brain to the thyroid. It doesn't tell you how much active thyroid hormone is actually circulating, whether it's converting properly, or whether something is blocking it at the cellular level. It's common to see patients with textbook hypothyroid symptoms — fatigue, weight gain, brain fog, feeling cold, constipation — while TSH reads “normal.”Cortisol. In short bursts, cortisol is your friend — it gets you moving and helps you respond to real threats. Chronically elevated cortisol is a different story. Your body reads sustained high cortisol as famine or threat, so it holds onto visceral fat (the fat around your organs) as an energy reserve and breaks down muscle tissue to convert into quick glucose. That's a double hit: your engine (muscle) shrinks while your fat stores grow. This is also why jumping straight into intense daily cardio when you're already exhausted and stressed tends to backfire — that kind of training spikes cortisol further, adding fuel to the exact hormone working against you. Exercise is medicine, but which exercise depends heavily on where you're starting from.S — Sun exposure: the signal almost everyone is missingThis is the piece most health-conscious people have never connected to their metabolism — and it goes well beyond “get sunlight for vitamin D.”Alpha-MSH. Ultraviolet light exposure triggers the release of alpha-melanocyte-stimulating hormone (alpha-MSH), produced via the pituitary–hypothalamic axis. Most people only know it as the hormone behind tanning, but alpha-MSH also acts directly on the hypothalamus — the brain region that governs hunger, body temperature, and energy expenditure. Through the melanocortin receptor system (MC3R/MC4R), alpha-MSH suppresses appetite and raises energy expenditure.⁴ ⁵ This is well-established endocrinology at the receptor level; most of the direct evidence for the light-triggered release piece specifically comes from animal and combined animal/human research, so treat “morning sunlight measurably curbs your appetite today” as a reasonable, biologically grounded hypothesis rather than a proven guarantee for every individual.Melanin. Most people think of melanin purely as sun protection. There's also a genuinely interesting — and genuinely early-stage — line of research suggesting melanin can absorb light energy and convert it into other forms of biological signaling.⁶ I want to be direct about where this stands: the clearest demonstrations of melanin's light-to-chemical-energy conversion come from turtle, avian, and in-vitro photoelectrochemical studies, not controlled human metabolic trials.⁷ It's a fascinating emerging area, not an established mechanism for human fat loss — I'm flagging it as something to watch, not something to build a protocol around yet.Melatonin. Most people file melatonin under “sleep supplement.” Its more fundamental role may be different: melatonin is one of the most potent antioxidants in the body, and a substantial body of research — much of it from melatonin researcher Russel Reiter's lab — supports it functioning as a mitochondria-targeted antioxidant that protects your cellular energy factories from oxidative damage.⁸ Melatonin production is directly regulated by light: it rises in darkness and is suppressed by light exposure, which ties it tightly to your circadian rhythm. When melatonin is disrupted — by artificial light at night, poor sleep, or insufficient daytime sunlight — your mitochondria lose one of their primary protectors, and cellular energy production can suffer as a result.Your morning light exposure sets your circadian clock, and that clock governs when cortisol should peak (morning) and fall (night), along with downstream thyroid output and insulin sensitivity. When the clock drifts, those downstream systems drift with it.S² — Sleep, Stress, and Systemic inflammation: the silent wreckersThese three are grouped together because they feed each other, forming what I'd call a metabolic wreckage loop.Sleep. One frequently cited controlled study found that cutting sleep from 8.5 to 5.5 hours a night — while holding calorie restriction constant — reduced the proportion of weight lost as fat by 55% and increased the loss of lean (muscle) mass by 60%.⁹ It's worth noting this came from a small trial (10 participants), though a separate free-living study found a similar shift in body composition over eight weeks.¹⁰ Sleep is also when your body releases growth hormone, the primary fat-burning, muscle-repairing hormone — cutting sleep short cuts those pulses short too. As for hunger hormones: classic research found sleep restriction lowers leptin (the “you're full” signal) and raises ghrelin (the “you're hungry” signal),¹¹ though it's fair to flag that more recent meta-analyses have found this effect isn't consistent across every study,¹² so treat it as a plausible contributor rather than a guarantee for any one person.Stress and inflammation. Chronic stress increases intestinal permeability — commonly called “leaky gut.” When the gut lining becomes more permeable, bacterial fragments and inflammatory particles can enter the bloodstream, and the immune system responds the way it would to an infection: with inflammatory cytokines. Those cytokines can interfere with insulin receptor signaling, contributing to insulin resistance that has nothing to do with what you ate that day.¹³ ¹⁴ Some early gut-microbiome research adds another wrinkle: in animal studies, mice with an “obese-type” microbiome extracted measurably more energy from identical food than mice with a “lean-type” microbiome, and this trait was transmissible via microbiota transplant.¹⁵ Human data shows a correlated shift in gut bacterial composition with obesity and weight loss, but the calorie-harvesting mechanism itself has been demonstrated most directly in mice — worth remembering before assuming it applies identically in people.So when do diet and exercise actually work?Diet and exercise are genuinely powerful tools — they're just not the starting point. They're amplifiers. If what's underneath is hormonal chaos, mitochondrial strain, and chronic inflammation, adding intense exercise and severe caloric restriction just amplifies that chaos. But once the foundation is addressed — light exposure is consistent, sleep is protected, inflammation is trending down, hormones are moving in the right direction — diet and exercise become the rocket fuel. It's the same idea as tuning a guitar before you play it: you wouldn't walk on stage with an out-of-tune instrument and just strum harder.The sequence: light and circadian rhythm first, then sleep, then inflammation, then hormones, then nutrition, then movement. Work from the foundation up, not the top down.Five things to start this week* Get morning sunlight. Within 30–60 minutes of waking, get outside for 10–20 minutes — no sunglasses, no sunscreen, no contacts if you can manage it. Face the direction of the sun without staring directly at it. This is free, takes 15 minutes, and is one of the most direct levers you have on circadian rhythm.* Protect melatonin at night. After sunset, start dimming household lights. Get off screens, or use blue-light-blocking glasses if you can't.* Ask for the right labs. Beyond a basic metabolic panel and TSH: fasting insulin, a full thyroid panel (free T3, free T4, reverse T3), a cortisol curve, and high-sensitivity CRP. These numbers point to which layer of MESS² to address first.* Remove one inflammatory food this week. Just one — refined seed oils (canola, soybean, vegetable) or ultra-processed snacks are a reasonable place to start.* Pause intense exercise if you're exhausted and inflamed. Counterintuitive, but if your body is in survival mode, a 20–30 minute walk lowers cortisol, improves insulin sensitivity, and moves your lymphatics better than another hard session would. Save high intensity for once the foundation is in place.The bottom lineYour metabolism isn't broken — it's very likely just misunderstood, and it's responding logically to signals it's been given: too little muscle to defend, a control panel sending mixed messages, a missing daily light signal, and a background hum of stress and inflammation. None of that is a character flaw. It's biology, and biology responds to sequence.Find your weak link in the framework above. Start at the foundation, and build from there — not the other way around.If this resonated and you want a structured way to work through the MESS² framework for your own situation, the Thrive 120 programs walk through it step by step, and a Metabolic Blueprint Session is a good next move if you want a second set of eyes on your specific labs and history. (Use THRIVER20 at checkout to get 20% off for the life of your membership)References* Preserve your muscle mass — Harvard Health: https://www.health.harvard.edu/staying-healthy/preserve-your-muscle-mass* Sarcopenia (Muscle Loss With Aging) — Cleveland Clinic: https://my.clevelandclinic.org/health/diseases/23167-sarcopenia* An Overview of Sarcopenia: Focusing on Nutritional Treatment Approaches — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11990658/* Alpha-Melanocyte-Stimulating Hormone-Mediated Appetite Regulation in the CNS — Neuroendocrinology, Karger: https://karger.com/nen/article/113/9/885/836595/Alpha-Melanocyte-Stimulating-Hormone-Mediated* Solar UVB radiation promotes α-MSH secretion via the pituitary–lung axis (human and mouse data) — PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497598/* Photoelectrochemical properties of melanin — Nature Precedings: https://www.nature.com/articles/npre.2007.1312.1.pdf* The Unsuspected Capacity of Melanin to Transform Light Energy into Chemical Energy (turtle/avian model) — ResearchGate: https://www.researchgate.net/publication/282330655_The_Unsuspected_Capacity_of_Melanin_to_Transform_Light_Energy_into_Chemical_Energy_and_the_Surprising_Anoxia_Tolerance_of_Chrysemys_Picta* Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas — Reiter et al., J Pineal Res: https://onlinelibrary.wiley.com/doi/10.1111/jpi.12360* Insufficient Sleep Undermines Dietary Efforts to Reduce Adiposity — Nedeltcheva et al. 2010, Annals of Internal Medicine (PMID 20921542): https://www.acpjournals.org/doi/abs/10.7326/0003-4819-153-7-201010050-00006* Muscle Loss While Dieting Jumped With Less Sleep (summary including Wang et al. 2018 free-living replication) — FitChef: https://fitchef.com/shorts/sleep-keep-muscle-while-dieting/* Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin, Elevated Ghrelin — Spiegel et al. 2004, Annals of Internal Medicine: https://www.acpjournals.org/doi/10.7326/0003-4819-141-11-200412070-00008* The Impact of Sleep Deprivation on Hunger-Related Hormones: A Meta-Analysis and Systematic Review — MDPI: https://www.mdpi.com/2673-4168/5/2/48* Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review — PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC10954893/* Cytokines and intestinal epithelial permeability: A systematic review — PubMed: https://pubmed.ncbi.nlm.nih.gov/37030338/* An obesity-associated gut microbiome with increased capacity for energy harvest (mouse model with human comparison) — Turnbaugh et al. 2006, Nature: https://www.nature.com/articles/nature05414 This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe
Stuck in an unhealthy church and not sure what to do next? When you're facing spiritual abuse and toxic church leadership, when sin keeps getting covered instead of confessed, you really only have four options. Comply. Conform. Confront. Or cut ties.In this episode of Shepherd's Heart, Stewart and Alycia White walk through all four biblically, so you can identify spiritual abuse for what it is and discern which door God is actually asking you to walk through right now. Every one of the four costs you something. None of them should be driven by fear, and none of them should be driven by anger either.We look at what compliance looks like right before it quietly turns into participation. We look at how good people conform to a toxic system without ever meaning to. And we look at what biblical confrontation actually requires before you ever get to the question of leaving a toxic church.Hear this clearly: Walking away from an abusive church is not walking away from Jesus. Sometimes it's the most faithful step toward Him you can take.This isn't cynicism, and it isn't an exit ramp from faith. We love the Bride of Christ. That's exactly why we take it this seriously.SCRIPTURES REFERENCEDActs 5:29 | Ephesians 5:11 | Romans 12:2 | Galatians 2:11-13 | Matthew 18:15-17 | 1 Timothy 5:19-20 | 1 Peter 3:17 | Romans 12:18 | Romans 16:17 | 1 Corinthians 5 | 2 Corinthians 7 | 2 Timothy 3 | James 1:5 | Ezekiel 34 | John 10CHAPTERS00:00 Spiritual Abuse in the Church: The Only Four Options You Have00:30 How to Identify Spiritual Abuse When Something Just Isn't Right01:16 Church Hurt and Biblical Discernment: Why We Do This Show01:58 Comply, Conform, Confront, or Cut Ties02:20 Option 1: Comply (Going Along Without Agreeing)03:43 When Compliance Becomes Participation in Sin | Acts 5:2904:49 Option 2: Conform (When You Adopt the Dysfunction)06:34 Stop Confusing Talent With Anointing08:20 Are You Defending What Once Broke Your Heart? | Romans 12:208:53 Option 3: Confront (Naming Sin in Church Leadership)10:07 Matthew 18:15-17: The Biblical Process for Confronting Sin11:23 Important Exception: Abuse, Assault, and Reporting It11:55 How "Two or Three Witnesses" Gets Weaponized | 1 Timothy 514:28 Confrontation Is Right Even When It Goes Badly18:42 Option 4: Cut Ties (When Leaving a Toxic Church Is Biblical)20:07 Is Leaving a Church Unbiblical? Matthew 18:17 Says No24:43 Walking Away From an Abusive Church Is Not Walking Away From Jesus26:28 Four Questions to Know Which Option God Is Asking of You31:57 These Aren't Four Personality Types, They're Four Doors34:24 Share This With Someone Sitting in That Hard PlaceIf this episode helped you, share it with somebody sitting in that hard place right now. You never know what one conversation can do.Data tells us that 96% of the people watching Shepherd's Heart haven't subscribed yet. If this is your kind of conversation, subscribe and turn on notifications so you don't miss the next one.Questions, or something you're walking through? Email us atinfo@shepherdsheartministries.orgShepherd's Heart is a podcast for Christ-followers who refuse to look the other way. Hosted by Stewart and Alycia White. New episodes every two weeks.#SpiritualAbuse #ChurchHurt #ToxicChurch #BiblicalDiscernment #ShepherdsHeartBecome a supporter of this podcast: https://www.spreaker.com/podcast/shepherd-s-heart--4100466/support.
Many women with PCOS are told their labs look normal while continuing to experience very real and persistent symptoms. In this episode we explore the important distinction between normal lab ranges, which are built around population averages designed to flag significant dysfunction, and optimal physiology, which is what actually supports hormone health, energy, cycle regularity, and overall wellbeing.Insulin Resistance with Normal Glucose: The Most Common Missing PieceNormal fasting glucose does not rule out insulin resistance. And for women with PCOS, this distinction is one of the most significant and most overlooked gaps in standard testing. In this episode we explain exactly how insulin resistance can develop and actively drive PCOS symptoms, including irregular cycles, acne, cravings, and weight changes, long before glucose breaks out of the normal range.Symptoms and Hormone Signaling: Why the Body Speaks Before the Labs DoHormone signaling changes gradually over time. And symptoms often appear during the compensation phase, before dysfunction becomes obvious on a lab panel. In this episode we explore why symptoms are meaningful physiological data that deserve attention and context rather than dismissal.Functional vs Conventional Perspectives on PCOS TestingStandard lab panels are valuable tools. But they are designed for a specific purpose and have real limitations when it comes to catching early stage hormonal and metabolic dysfunction. In this episode we offer a balanced, nuanced perspective on the value and the limitations of conventional testing for women with PCOS.Stress Physiology and What Basic Labs Often MissCortisol dysregulation, adrenal strain, and early inflammatory load may not always show clearly on a basic lab panel. But they produce real, measurable symptoms in the women experiencing them. In this episode we discuss how stress physiology affects PCOS hormone health in ways that standard testing frequently underestimates.Ovulation and Metabolism: What Cycle Changes Actually CommunicateThe menstrual cycle is one of the most sensitive vital signs a woman has. Cycle irregularity or absence often reflects whole-body physiological stress long before other markers flag on a standard panel. In this episode we explore what cycle changes are actually communicating about metabolic and hormonal health.Understanding Body Feedback: Why Physiological Literacy Changes EverythingPhysiological literacy, the ability to read your own symptom experience as meaningful body feedback, is one of the most empowering tools a woman with PCOS can develop. In this episode we introduce what physiological literacy looks like in practice and why understanding your body's communication changes the entire healing experience.You can take the quiz to discover your root cause hereLearn more about the PCOS Root Cause BootcampLet's continue the conversation on Instagram! What did you find helpful in this episode and what follow-up questions do you have?The full list of Resources & References Mentioned can be found on the Episode webpage at: https://nourishedtohealthy.com/ep-194
What happens when commitment begins to slip within a ministry team?In this episode of the When She Serves Podcast, Brenda Leavenworth is joined by Shirley Ruiz and Tami Peña for the third conversation in the series on dysfunction in ministry. This episode focuses on lack of commitment—one of the challenges that can quietly undermine the health, effectiveness, and unity of a ministry.Commitment in ministry goes beyond simply showing up. It involves faithfully following through, taking responsibility, communicating well, and recognizing that the way we serve affects the people serving alongside us. When commitment is inconsistent, the burden can fall on others, expectations can become unclear, and frustration can grow within a team.Brenda, Shirley, and Tami discuss the realities of commitment in ministry and offer practical encouragement for both ministry leaders and those who serve alongside them. Together, they explore how leaders can address a lack of commitment with wisdom and grace while cultivating a culture where people understand the importance of faithfully serving others.Why commitment matters to the health of a ministryHow a lack of commitment can affect an entire ministry teamThe difference between being willing to serve and being committed to servingHow inconsistency can create additional burdens for other team membersThe importance of clear expectations and communicationHow leaders can address commitment issues without creating unnecessary conflictThe role of accountability in healthy ministryExtending grace while still maintaining appropriate standardsHow leaders can model faithfulness and commitment for those they servePractical ways to build a culture of reliability and trust within a ministry team✨ Commitment affects more than the individual. When one person repeatedly fails to follow through, others often have to compensate.✨ Serving is a responsibility. Ministry is a privilege, but it also requires faithfulness, dependability, and a willingness to follow through.✨ Clear expectations matter. Sometimes what appears to be a commitment problem is actually a communication problem. Healthy teams need clarity about roles, responsibilities, and expectations.✨ Grace and accountability belong together. Leaders can extend grace while still addressing patterns that negatively affect the ministry.✨ Faithfulness builds trust. Consistently doing what we say we will do creates a healthier environment where ministry teams can flourish.✨ Leaders set the example. One of the best ways to cultivate commitment is to model it through our own service, communication, and follow-through.A lack of commitment can be one of the more difficult issues for a ministry leader to address because people are involved, relationships matter, and the desire to extend grace is real.But avoiding difficult conversations doesn't necessarily protect unity. In many cases, healthy communication, clear expectations, and loving accountability can protect the unity of a team.Ministry leaders are called not simply to accomplish tasks, but to shepherd people. Addressing dysfunction well means seeking both truth and grace—caring about the person while also caring about the health of the ministry.This episode's discussion connects naturally with several biblical principles concerning faithfulness, serving others, stewardship, and the life of the church:Colossians 3:23–24 — Serving wholeheartedly as unto the Lord1 Corinthians 4:2 — The importance of being found faithfulGalatians 6:9 — Not growing weary in doing good1 Peter 4:10 — Using our gifts to serve one anotherRomans 12:10–11 — Serving with diligence and devotionWhen She Serves PodcastListen to When She ServesWhen She ServesVisit the When She Serves websiteReliance ChurchLearn more about Reliance ChurchFor more episodes, resources, conferences, and encouragement for women serving in ministry:Visit When She ServesBrowse the podcast episodes
When dysfunction is all you know, it can feel normal.For Michaela, growing up with a narcissistic father meant fear, control, walking on eggshells, protecting her younger siblings, and even parenting her own parents. For years, she didn't realize how unhealthy her family dynamics were. It wasn't until she encountered healthy families that she began to see how different love could look.In this episode, Michaela shares how those relationships helped reshape her understanding of family, love, boundaries, and healing.We talk about:Why unhealthy family dynamics can feel normal when you grow up inside themWhat it's like growing up with a narcissistic and controlling parentHow healthy families and mentors can show you a different way to loveHow to stop carrying responsibility for everyone around youWhy forgiveness doesn't always require reconciliationIf you grew up with a narcissistic, abusive, or deeply dysfunctional parent and want to build something healthier, this episode is for you.Resources MentionedFree Guide: 7 Ways to Work Through the Pain of Your Parents' DivorceBook: It's Not Your FaultShare Your Story with Restored
On this episode of A Must Win Game with Maggie Gray, Maggie takes on the latest NFL storylines, makes a bold Minnesota Vikings playoff prediction, and welcomes St. Louis Cardinals host and reporter Dani Wexelman for an inside look at Major League Baseball. First, Maggie breaks down the dysfunction surrounding the Las Vegas Raiders after veteran stars Maxx Crosby and Kirk Cousins got into a training camp scuffle that resulted in both players being suspended. These are established NFL veterans who know better—but what does this kind of chaos say about the Raiders organization? More importantly, how could a dysfunctional Raiders franchise affect the development of future quarterback Fernando Mendoza? Maggie explains why she's genuinely concerned about Mendoza's future in Las Vegas and questions whether Tom Brady's involvement with the Raiders has produced the kind of organizational transformation many expected. Then Maggie makes a bold NFL prediction: she's buying the Minnesota Vikings as a playoff team. After Kyler Murray won the Vikings' starting quarterback job over J.J. McCarthy, Maggie argues that the quarterback competition may have been one of the easiest of Murray's career. But could Minnesota be the perfect environment for Murray to resurrect his NFL career? The Vikings face a brutal NFC North that includes the Lions, Packers and Bears—but Maggie is going out on a limb and predicting Minnesota will somehow make the playoffs. Then, Dani Wexelman, host and reporter for the St. Louis Cardinals, joins Maggie for a wide-ranging conversation about baseball and life inside an MLB clubhouse. Dani discusses: Why the St. Louis Cardinals may be ahead of schedule The Cardinals' future and direction Her thoughts on the Los Angeles Dodgers The New York Yankees and their expectations What it's like being a woman working inside the clubhouse of professional athletes Her experience covering Major League Baseball The changing landscape of sports media and baseball coverage TOPICS COVERED
nside today's episode, I break down the emerging research on how high blood sugar affects the gut barrier and why hyperglycemia and leaky gut are more connected than most coaches and clinicians appreciate. I walk through the Danish observational study of 69,000 people with type 2 diabetes tracked over more than a decade, why cumulative A1C exposure predicted a 64% higher risk of hospitalization for infection while a single snapshot at diagnosis did not, and what that tells us about the difference between one lab value and a trajectory. Topics discussed: - Blood Sugar and Gut Health as One Conversation- The Danish Diabetes and Infection Study- Why Cumulative A1C Beats a Single Snapshot- The Weizmann Institute Human Study- What Cell Culture Studies Reveal- Separating Blood Sugar From Obesity as the Driver- The GLUT2 Transporter Mechanism- Tight Junctions and Gut Barrier Architecture- The Feed-Forward Loop Between Blood Sugar and Gut Health---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscienceYoutube: SamMillerScience Facebook: The Nutrition Coaching Collaborative CommunityTikTok: @sammillerscience----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
In this sermon, Pastor Ricky Temple teaches that receiving the dream God has for your life does not mean dysfunction will disappear, as seen in the family of Isaac, Rebekah, Jacob, and Esau. He challenges believers to manage favoritism, manipulation, unhealthy appetites, and short-term decisions so they do not sacrifice the future God has prepared for temporary satisfaction.
Adam helped a client who had been suffering from no burp syndrome, a condition where burping feels impossible, to connect with the idea of allowing a natural response by not restricting or suppressing. The client experienced progress from an earlier session but wanted to feel that burping could be natural and effortless, so Adam used various metaphors and open loops to give the unconscious permission to stop resisting. Get 50% off a consultation call with Adam using the code PODCAST. Click here to schedule: https://courses.adamcox.co.uk/workwithadam
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If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects. In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge. So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below. Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBibliographyCore Eye Anatomy, Retina, Optic Nerve, and Visual PathwaysBelliveau, A. P., & Somani, A. N. “Pupillary Light Reflex.” StatPearls. Treasure Island, FL: StatPearls Publishing, updated 2023.Cleveland Clinic. “Optic Nerve: What It Is, Function, Anatomy & Conditions.” Cleveland Clinic, updated 2024.Gupta, M., & Ireland, A. C. “Neuroanatomy, Visual Pathway.” StatPearls. Treasure Island, FL: StatPearls Publishing, updated 2022.Kolb, H. “Simple Anatomy of the Retina.” Webvision: The Organization of the Retina and Visual System. 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Englewood Cliffs, NJ: Prentice-Hall, 1973.Laeng, Bruno, Sylvain Sirois, and Gustaf Gredebäck. “Pupillometry: A Window to the Preconscious?” Perspectives on Psychological Science 7, no. 1, 2012: 18–27.Mathôt, Sebastiaan. “Pupillometry: Psychology, Physiology, and Function.” Journal of Cognition 1, no. 1, 2018.Piquado, Tepring, David Isaacowitz, and Arthur Wingfield. “Pupillometry as a Measure of Cognitive Effort in Younger and Older Adults.” Psychophysiology 47, no. 3, 2010: 560–569.Zekveld, Adriana A., Sophia E. Kramer, and Tammo Houtgast. “The Pupil Dilation Response to Auditory Stimuli: Current State of Knowledge.” Trends in Hearing 22, 2018.Emotion, Attraction, Arousal, and the PupilBradley, Margaret M., Laura Miccoli, Miguel A. Escrig, and Peter J. Lang. “The Pupil as a Measure of Emotional Arousal and Autonomic Activation.” Psychophysiology 45, no. 4, 2008: 602–607.de Winter, Joost C. F., et al. “Replicating Five Pupillometry Studies of Eckhard Hess.” International Journal of Psychophysiology 165, 2021: 145–161.Hess, Eckhard H. “Attitude and Pupil Size.” Scientific American 212, no. 4, 1965: 46–54.Hess, Eckhard H., and James M. Polt. “Pupil Size as Related to Interest Value of Visual Stimuli.” Science 132, no. 3423, 1960: 349–350.Lang, Peter J., Margaret M. Bradley, and Bruce N. Cuthbert. International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Gainesville: University of Florida, 2008.Pan, J., et al. “The Effects of Emotional Arousal on Pupil Size Depend on Background Luminance and Stimulus Type.” Scientific Reports 14, 2024.Locus Coeruleus, Norepinephrine, Salience, and AttentionAston-Jones, Gary, and Jonathan D. Cohen. “An Integrative Theory of Locus Coeruleus–Norepinephrine Function: Adaptive Gain and Optimal Performance.” Annual Review of Neuroscience 28, 2005: 403–450.Joshi, Siddhartha, Yin Li, Ram M. 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McGaugh. “Mechanisms of Emotional Arousal and Lasting Declarative Memory.” Trends in Neurosciences 21, no. 7, 1998: 294–299.McGaugh, James L. “Memory—A Century of Consolidation.” Science 287, no. 5451, 2000: 248–251.McGaugh, James L. “The Amygdala Modulates the Consolidation of Memories of Emotionally Arousing Experiences.” Annual Review of Neuroscience 27, 2004: 1–28.Seligman, Rebecca, and Laurence J. Kirmayer. “Dissociative Experience and Cultural Neuroscience: Narrative, Metaphor and Mechanism.” Culture, Medicine, and Psychiatry 32, 2008: 31–64.Seligman, Rebecca, Ryan A. Brown, and Laurence J. Kirmayer. “Theory and Method at the Intersection of Anthropology and Cultural Neuroscience.” Social Cognitive and Affective Neuroscience 5, no. 2–3, 2010: 130–139.Whitehouse, Harvey. Arguments and Icons: Divergent Modes of Religiosity. Oxford: Oxford University Press, 2000.Whitehouse, Harvey. Modes of Religiosity: A Cognitive Theory of Religious Transmission. Walnut Creek, CA: AltaMira Press, 2004.Ritual, Synchrony, Social Bonding, and Embodied MeaningHobson, Nicholas M., Juliana Schroeder, Jane L. Risen, Dimitris Xygalatas, and Michael I. Norton. “The Psychology of Rituals: An Integrative Review and Process-Based Framework.” Personality and Social Psychology Review 22, no. 3, 2018: 260–284.Jackson, Joshua Conrad, Brock Bastian, and others. “Synchrony and Physiological Arousal Increase Cohesion and Cooperation in Large Naturalistic Groups.” Scientific Reports 8, 2018.McCauley, Robert N., and E. Thomas Lawson. Bringing Ritual to Mind: Psychological Foundations of Cultural Forms. Cambridge: Cambridge University Press, 2002.Rappaport, Roy A. Ritual and Religion in the Making of Humanity. Cambridge: Cambridge University Press, 1999.Turner, Victor. The Ritual Process: Structure and Anti-Structure. Chicago: Aldine, 1969.Xygalatas, Dimitris. Ritual: How Seemingly Senseless Acts Make Life Worth Living. 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Fun fact, the art is all based on the eyeball.
Send us Fan MailIn this prospective study, Adrianne and Nim dig into an area with almost no normative pediatric data: right ventricular diastolic function. Comparing 57 infants with RV pressure overload after intervention for pulmonic stenosis or tetralogy of Fallot to 134 healthy controls, the authors found a consistent pattern, reduced beat-to-beat variability, a higher atrial contribution to filling, and an E/A ratio inversion that was nearly universal in the CHD group versus about half of controls. It's one of the first real attempts to define what a right-sided diastolic pattern actually looks like in this population. But without a comparison against cardiac catheterization, the hosts agree the findings are hypothesis-generating at best, a starting point for a multi-parametric approach, not a reason to skip an invasive workup.----Echocardiographic Markers of Right Ventricle Diastolic Dysfunction in Neonates and Infants with Congenital Heart Disease. Cantinotti M, Capponi G, Scalese M, Palladino E, Giordano R, Franchi E, Viacava C, Corana G, Marchese P, Pizzuto A, Assanta N, Santoro G. J Clin Med. 2025 Dec 23;15(1):98. doi: 10.3390/jcm15010098. PMID: 41517351 Free PMC article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
It's Hump Day at The Majority Report On today's program: Dr. Anthony Fauci testifies before the Senate Homeland Affairs & Governmental Affairs Committee Hearing and calls out committee chair Sen. Rand Paul for his "unhinged obsession" with him and then invokes the fifth amendment. As the Republicans focus on relitigating early COVID policy, the country is reeling from outbreaks of cyclospora, salmonella, measles, screwworm and the return of whooping cough and polio. This is all in the wake of DOGE gutting the CDC's programs dedicated to managing such outbreaks. David Hogg, former DNC vice-chair and president of Leaders We Deserve, joins the show for a conversation about the dysfunction within the DNC. Biplob Kumar Das, investigative reporter joins to discuss his piece published by Drop Site News, "India's Cockroach Protests End as Modi Government Bows to Demands" In the Fun Half: Lindsey Graham's funeral brings out all the biggest demons from Trump to Netanyahu, and the eulogies are as selfish and hilarious as one would imagine them to be. Hannity uses his eulogy to brown nose to Trump. While Trump's remarks centered around how no one like Graham and that he never saw a war he didn't like. Minnesota State Senator John Hoffman says that when he was in the ICU recovering from a shooting, Angie Craig sent over staffers to seek his endorsement for her Senate campaign. As grocery prices rise at a record pace, NYC Mayor Zohran Mamdani announces that staple products will be priced at 30% lower than market rate. Rep. Max Miller (R-OH) is accused of horrific abuse towards his wife and children. all that and more. To connect and organize with your local ICE rapid response team visit ICERRT.com The Congress switchboard number is (202) 224-3121. You can use this number to connect with either the U.S. Senate or the House of Representatives. Follow us on TikTok here: https://www.tiktok.com/@majorityreportfm Check us out on Twitch here: https://www.twitch.tv/themajorityreport Find our Rumble stream here: https://rumble.com/user/majorityreport Check out our alt YouTube channel here: https://www.youtube.com/majorityreportlive Gift a Majority Report subscription here: https://fans.fm/majority/gift Subscribe to the AM Quickie newsletter here: https://am-quickie.ghost.io/ Join the Majority Report Discord! https://majoritydiscord.com/ Get all your MR merch at our store: https://shop.majorityreportradio.com/ Get the free Majority Report App!: https://majority.fm/app Go to https://JustCoffee.coop and use coupon code majority to get 10% off your purchase Check out today's sponsors: FAST GROWING TREES: Get 20% off your first purchase. FastGrowingTrees.com/majority SUNSET LAKE CBD: Use coupon code "Left Is Best" (all one word) for 20% off of your entire order at SunsetLakeCBD.com Follow the Majority Report crew on Twitter: @SamSeder @EmmaVigeland @MattLech On Instagram: @MrBryanVokey Check out Matt's show, Left Reckoning, on YouTube, and subscribe on Patreon! https://www.patreon.com/leftreckoning Check out Matt Binder's YouTube channel: https://www.youtube.com/mattbinder Subscribe to Brandon's show The Discourse on Patreon! https://www.patreon.com/ExpandTheDiscourse Check out Ava Raiza's music here! https://avaraiza.bandcamp.
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