Podcasts about iav

À Los Angeles, les pompiers essayent toujours de contenir les flammes, plus d'une semaine après le début des incendies. Selon le dernier bilan, au moins 24 personnes ont trouvé la mort. Une catastrophe historique, marquée par un flot d'infox d'une rare intensité sur les réseaux. L'origine de ces incendies, le travail des pompiers, les rescapés, rien n'échappe à la désinformation, à tel point que certaines des images les plus partagées en ligne sont irréelles ou sorties de leur contexte. Si vous avez passé du temps sur les réseaux sociaux ces derniers jours, vous avez probablement été confronté à l'une de ces deux images aériennes, montrant une maison au toit rouge, prétendument épargnée par les flammes à Los Angeles. Tout le quartier semble avoir été détruit, sauf ces luxueuses résidences. Si les deux maisons se ressemblent, ce ne sont pas les mêmes. L'une est en bord de mer, l'autre en pleine ville.Les internautes qui partagent ces photos affirment qu'elles montreraient « la maison d'un croyant de Los Angeles, miraculeusement protégée par Dieu ». Un récit sur lequel plusieurs auditeurs nous ont alertés.Image détournée et générée par IAVérification faîte, ces deux images n'ont rien à voir avec les incendies en cours à Los Angeles. La première photo est bien authentique, mais elle n'a pas été prise dans la cité des anges. Une recherche par image inversée permet de retrouver sa trace dans la banque d'images de l'Agence France Presse (AFP). On y apprend en légende qu'elle montre une maison dans le quartier de Lahaina, à la suite des incendies mortels à Hawaï, en août 2023. La résidence avait été épargnée notamment grâce à sa toiture en tôle épaisse et à l'absence de végétation à proximité.Concernant le deuxième cliché, si visuellement tout semble réel, l'image a en réalité été générée par une intelligence artificielle. Le seul moyen de s'en rendre compte consiste à faire une recherche par image inversée sur Google, puis d'aller dans l'onglet « À propos de l'image ». Un message apparaît alors indiquant « image créée avec l'IA de Google ».Comment Google sait-il que quelqu'un a généré cette image avec son intelligence artificielle ? Pour son outil de génération d'image, baptisé Imagen, la firme américaine utilise ce que l'on appelle des watermarks, des filigranes, invisibles à l'œil nu, mais identifiables par un logiciel. Ce tatouage numérique atteste donc de l'utilisation de l'intelligence artificielle, mais sans faire cette démarche de vérification, il est impossible de s'en rendre compte.Instrumentalisation complotiste et religieuseCette image synthétique fait l'objet de nombreuses instrumentalisations. Religieuse d'abord, avec plusieurs messages parlant d'une intervention divine. Certains affirment, à tort, que cette maison appartenait à une famille chrétienne, d'autres à une famille musulmane.Et puis certains complotistes ont aussi diffusé cette image, assurant que l'incendie était volontaire et ne ciblait que certaines habitations. Deux récits trompeurs vus des dizaines de millions de fois sur les réseaux sociaux. Résultat, cette infox figure aujourd'hui parmi les images les plus vues concernant les incendies de Los Angeles. On est donc là face à un énième exemple de détournement de l'IA qui perturbe les perceptions d'un événement mondial et invisibilise les vraies images de la catastrophe.

Willkommen beim "Genau Mein Agil Podcast"! In dieser Folge haben wir einen ganz besonderen Gast: Daniel Hess, Abteilungsleiter für bei der IAV, einem der führenden deutschen Unternehmen im Bereich Automotive Engineering. Unser heutiges Thema dreht sich um das Agile Manifest und den Umgang damit. Agile Methoden sind aus der heutigen Arbeitswelt nicht mehr wegzudenken, aber wie können wir das Agile Manifest wirklich verstehen und in unseren Arbeitsalltag integrieren? Egal ob Sie neu im agilen Umfeld sind oder bereits Erfahrung haben, diese Folge bietet wertvolle Einblicke und Inspirationen, um das Beste aus dem Agile Manifest herauszuholen und Ihre Arbeitsweise zu optimieren. Shownotes: LinkeIn-Profil: www.linkedin.com/in/mariobrueckne…nt-activity/all/ Webseite: www.agilecouch.net/ Webseite: www.soliganisation.de/ Wenn euch diese Folge gefallen hat, gebt mir euer Gefällt mir, Daumen hoch oder die 5 Sterne auf Apple Podcast, Spotify, Deezer & Co – und teilt und liked uns auf Instagram, Facebook, LinkedIn und Twitter!

Ginkgo biloba, known for its distinctive fan-shaped leaves, has been used in traditional medicine for centuries, particularly in Asia. Ginkgo biloba is often touted as an herb for brain health, such as improving memory and cognition. This reputation does a great disservice to the most versatile herb in the world. Ginkgo biloba can be used as a potent antiviral agent for a variety of viruses. Ginkgo biloba has some key bioactive antiviral components: Flavonoids and Terpenoids: Ginkgo leaves contain high levels of flavonoids and terpenoids, compounds known for their antioxidant properties. These substances contribute to the antiviral activity of the plant. Ginkgolides and Bilobalides: These are unique terpene trilactones found in Ginkgo biloba, which have specific antiviral activities. Ginkgo Biloba's Mechanisms of Antiviral Action The antiviral properties of Ginkgo biloba are multi-faceted, involving multiple mechanisms: Inhibition of the fusions and synthesis of proteins in the viruses herpes simplex 1 and 2 (HSV-1 and HSV-2). Inhibition of genome replication in cytomegalovirus (HCMV) and Zika virus (ZIKV). Inhibition of viral fusion proteins in HIV, Ebola virus (EBOV), influenza A virus (IAV), and Epstein-Barr virus (EBV). Inhibition of the targeting protein and DNA of coronoviruses (SARS-CoV-2), varicella zoster virus (VZV), and measles virus. Inhibition of Viral Entry and Replication: Some studies suggest that Ginkgo biloba extracts can interfere with the ability of viruses to enter host cells or replicate. This is a key step in preventing the spread of viral infections. Immune System Modulation: Ginkgo biloba might enhance the body's immune response against viral infections. By modulating immune functions, it could help in controlling viral spread and severity. Anti-inflammatory Effects: The anti-inflammatory properties of Ginkgo biloba can be beneficial in reducing the severity of symptoms associated with viral infections. Research on Ginkgo Biloba's Antiviral Properties Anti-MERS-CoV and Anti-HCoV-229E Properties: A study focused on the antiviral activities of Ginkgo biloba leaf extracts against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Human Coronavirus 229E (HCoV-229E). Inhibition of Enveloped Viruses: Research published in Scientific Reports discussed how ginkgolic acid, a component of Ginkgo biloba, inhibits the fusion of enveloped viruses. The study found that ginkgolic acid had a strong inhibitory effect on Human Cytomegalovirus (HCMV) and also tested its effects on Herpes Simplex Virus-1 (HSV-1) and Zika Virus (ZIKV). Researchers also found broad spectrum inhibition by ginkgolic acid of all three classes of fusion proteins including HIV, Ebola virus (EBOV), influenza A virus (IAV) and Epstein Barr virus (EBV). In addition, inhibition was found of a non-enveloped adenovirus. The authors conclude that ginkolic acids may potentially be used to treat acute infections (e.g. Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. HSV-1, HSV-2 and varicella-zoster virus (VZV)). It was observed that ginkgolic acid could inhibit the entry of these viruses into cells, thereby blocking viral replication. Another study entitled, “Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay” found that ginkgolic acids from ginkgo biloba inhibited the SARS-CoV-2 virus from binding to the ACE2 receptor and thus could potentially be helpful in acute COVID-19 infections. I use VascuSelect from Moss Nutrition which contains 120 mg of ginkgo biloba, 100 mg of grape seed extract, and 100 mg of mango fruit powder per capsule for acute and chronic viruses dosed 1 capsule once or twice a day with or without food. Grape seed extract and mango fruit powder have also been shown to have antiviral properties. This trio of herbs not only has antiviral prop...

Dr. Frederick Kibenge author of "A One Health approach to mitigate the impact of influenza A virus (IAV) reverse zoonosis is by vaccinating humans and susceptible farmed and pet animals in: American Journal of Veterinary Research - Ahead of print (avma.org)" and "Continuous surveillance and viral discovery in animals and humans are a core component of a one-health approach to address recent viral reverse zoonoses in: Journal of the American Veterinary Medical Association - Ahead of print (avma.org)" discusses reverse zoonoses. Hosted by Associate Editor Dr. Sarah Wright and Editor-in-Chief Dr. Lisa Fortier.INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA OR AJVR?JAVMA: https://avma.org/JAVMAAuthorsAJVR: https://avma.org/AJVRAuthorsFOLLOW US:JAVMA:Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR: Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA and AJVR LinkedIn: https://linkedin.com/company/avma-journals#VeterinaryVertexPodcast #JAVMA #AJVRINTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.530999v1?rss=1 Authors: Lemcke, R., Egebjerg, C., Berendtsen, N. T., Egerod, K. L., Thomsen, A. R., Pers, T. H., Christensen, J. P., Kornum, B. R. Abstract: Infection with Influenza A virus (IAV) causes the well-known symptoms of the flu, including fever, loss of appetite and excessive sleepiness. These responses, mediated by the brain, will normally disappear once the virus is cleared from the system, but a severe respiratory virus infection may cause long-lasting neurological disturbances. These include encephalitis lethargica and narcolepsy. The mechanisms behind such long lasting changes are unknown. The hypothalamus is a central regulator of the homeostatic response during a viral challenge. To gain insight into the neuronal and non-neuronal molecular changes during an IAV infection, we intranasally infected mice with an H1N1 virus and extracted the brain at different time points. Using single-nucleus RNA sequencing (snRNA-seq) of the hypothalamus, we identify transcriptional effects in all identified cell populations. The snRNA-seq data showed the most pronounced transcriptional response at 3 days past infection, with a strong downregulation of genes across all cell types. General immune processes were mainly impacted in microglia, the brain resident immune cells, where we found increased numbers of cells expressing pro-inflammatory gene networks. In addition, we found that most neuronal cell populations downregulated genes contributing to the energy homeostasis in mitochondria and protein translation in the cytosol, indicating potential reduced cellular and neuronal activity. This might be a preventive mechanism in neuronal cells to avoid intracellular viral replication and attack by phagocytosing cells. This is complemented by increased activity of microglia monitoring their surroundings. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.21.521536v1?rss=1 Authors: Vale-Costa, S., Etibor, T. A., Bras, D., Sousa, A. L., Amorim, M. J. Abstract: Many viruses that threaten public health establish condensates via phase transitions to complete their lifecycles, and knowledge on such processes is key for the design of new antivirals. In the case of influenza A virus, liquid condensates known as viral inclusions are sites dedicated to the assembly of its 8-partite RNA genome. Liquid viral inclusions emerge near the endoplasmic reticulum (ER) exit sites, but we lack the molecular understanding on how the ER contributes to their biogenesis. We show here that viral inclusions develop at remodeled ER sites and display dynamic interactions using the ER, including fusion and fission events and sliding movements. We also uncover a novel role for the host factor, ATG9A, in mediating the exchange of viral inclusions between the ER and microtubules. Depletion of ATG9A arrests viral inclusions at microtubules and prevents their accumulation at the ER, leading to a significantly reduced production of viral genome complexes and infectious virions. In light of our recent findings, we propose that a remodeled ER supports the dynamics of liquid IAV inclusions, with ATG9A acting locally to facilitate their formation. This work advances our current knowledge regarding influenza genome assembly, but also reveals new roles for ATG9A beyond its classical involvement in autophagy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

O nosso entrevistado é engenheiro de masterização (mastering engineer), com mestrado em Artes pela Middle Tennessee State University (MTSU) e proprietário de um moderno estúdio profissional de masterização em São Paulo (Capital), que leva o seu nome. Formado em Publicidade e Propaganda nos anos 1990, ainda na faculdade ele descobriu que a sua verdadeira paixão e vocação era trabalhar no ambiente da música e dos sons, dos estúdios e seus incríveis equipamentos. Dos tempos da faculdade até hoje, ele já fez um pouco de tudo: de técnico de som a sócio de uma produtora de publicidade; de operador de som de shows ao vivo a gravação de discos em estúdios; até se tornar professor, por mais de 10 anos, no Instituto de Áudio e Vídeo (IAV), em São Paulo, onde também foi aluno. Sempre divertido, inteligente e autêntico, durante a nossa conversa ele relembrou como foi o início da carreira e as primeiras experiências profissionais no universo musical; explicou em detalhes sobre o trabalho de um engenheiro de masterização; falou da importância desta etapa final de produção musical antes da entrega para os ouvintes; contou sobre a experiência de fazer o mestrado em Artes nos Estados Unidos e discorreu sobre gravação e mixagem 3D, tema da sua tese de mestrado. Nesta entrevista, ele também fez uma divertida análise do dia a dia de um fã ouvindo músicas nas plataformas de streaming e interagindo nas redes sociais; contou sobre as suas aventuras no mundo da coquetelaria, que rendeu até um Instagram repleto de receitas de drinques e, falou sobre a corrida, esporte ao qual se dedica nos últimos anos. É com muita alegria, já com a mesa de som ligada e preparada para mais uma gravação, que recebemos neste episódio do podcast Outra Visão, Maurício Gargel, o Mau, o Maurício marido da Dani, que eu sei, tem muito a nos ensinar e várias histórias para contar. Acompanhe a entrevista. Entrevista realizada dia 5 de maio de 2022. LINKS – Maurício Gargel Maurício Gargel Audio Mastering - https://mauriciogargel.com/ Instagram – Estúdio @gargelmastering - https://www.instagram.com/gargelmastering/ Instagram – Coquetelaria by MGargel - @mgargel - https://www.instagram.com/mgargel/ Headliner Magazine - https://headlinermagazine.net/latest-us-issue.html XXX O podcast Outra Visão é produzido e apresentado, com muita alegria, pelo jornalista Paulo Cunha, o Paulão

Devocional do dia 20/03/2022, com o tema "Aprender". O relato de hoje conta como findou uma seca de três anos que Deus enviara sobre o reino de Israel, a fim de mostrar que Iavé era o Deus verdadeiro. Ela terminou como começara: mediante ordem divina.  Leitura bíblica: 1 Reis 18.41-46 Versículo-Chave: Todos caíram prostrados e gritaram: “O SENHOR é Deus! O SENHOR é Deus!” (1Reis 18.39b) See omnystudio.com/listener for privacy information.

Uno de los grandes desafíos que enfrentamos en la producción porcina, está relacionado con la salud de los cerdos. Las enfermedades infecciosas virales generan impactos económicos devastadores y su control efectivo es motivo de gran preocupación para la comunidad científica que trata de dar respuestas. El Circovirus Porcino 3 (PCV3), es un virus que se detectó en animales que mostraban fallo reproductivo, inflamación multisistémica y síndrome de la dermatitis y nefropatía porcina (PDNS); desde entonces, se ha encontrado en cerdos de todo el mundo, con o sin manifestaciones clínicas; y a pesar que existen algunas vacunas, es necesario seguir investigando para determinar una clara definición de caso y su impacto económico. Los que vas a aprender: ¿Qué sabemos sobre la infección por Circovirus Porcino 3 (PCV3)? Relación con el Circovirus porcino tipo 2 (PCV2). Importancia de la genotipificación en el control efectivo de este agente. Aspectos claves sobre la vacunación para PCV2. ¿Qué desafíos nos trae la presentación subclínica? Nuestro Invitado: El Dr. Pablo Piñeyro es un reconocido investigador en diagnóstico patológico en la industria porcina. Se tituló como Médico Veterinario en la Universidad de La Plata en Argentina, para luego realizar una maestría en Ciencias Veterinarias en Washington State University y un doctorado en el mismo campo, en la Universidad de La Plata. También cuenta con un doctorado en Ciencias Biomédicas en el Virginia Polytechnic Institute and State University. Actualmente se desempeña como profesor asociado y patólogo en Iowa State University, donde realiza intensa investigación sobre PCV2, PCV3, PRRSV y IAV.

In dieser Ausgabe von "Status fünf" sprechen wir über den Spannungswarner "P2" von der Firma "Zimmermann - Produktentwickler" und einem Rettungskräfteseminar von der Firma "IAV Fahrzeugsicherheit". Was diese zwei Themen verbindet, wobei einem im Einsatz der "P2" helfen kann und was das Seminar der Firma IAV von anderen Technischen Hilfeleistungsseminaren unterscheidet, erfahrt ihr in unserer XXL Ausgabe. * Weitere Informationen zum Thema Rettungskräftetraining IAV unter https://www.iav.com/was-uns-bewegt/live-crashtest-rettungskraefte-training-der-iav-s/ oder per Email livecrash@iav.de * * Weitere Informationen zum Thema P2 von der Firma Zimmermann unter https://www.zimmermann.expert oder per Email info@zimmermann.expert *

Devocional do dia 18/10/2021, com o tema "Alegria eterna". O que seria fazer o que é mau ou o correto diante do Senhor? No contexto da monarquia israelita, fazer o mal seria não ouvir os profetas, andar como os antepassados que não serviram a Iavé. Leitura bíblica: Levítico 23.39-44 Versículo-Chave: [Deus] lhes enxugará dos olhos toda lágrima (Ap 21.4a). See omnystudio.com/listener for privacy information.

Devocional do dia 17/10/2021, com o tema "Memórias". O que seria fazer o que é mau ou o correto diante do Senhor? No contexto da monarquia israelita, fazer o mal seria não ouvir os profetas, andar como os antepassados que não serviram a Iavé. Leitura bíblica: 2 Reis 22.1-2 Versículo-Chave: Se andares nos meus caminhos, obedecendo aos meus estatutos e aos meus mandamentos, como fazia Davi, teu pai, eu prolongarei os teus dias (1Rs 3.14). See omnystudio.com/listener for privacy information.

the increasing integration of active driver assist and safety systems can influence the occupant seating posi- tion by the intervention in longitudinal and transverse dynamics and future seating concepts. to ensure opti- mized protection furthermore, IaV relies especially on passenger compartment sensor systems in addition to environment sensing. Any Suggestion or question feel free to mail at: ojhashubham11@gmail.com --- Send in a voice message: https://anchor.fm/shubham-ojha/message

No dia que o IAV completa 4 anos, Rodrigo Rosa traz a importância de dar o 1o passo. Nos siga em @iavdesenvolvimento

Com base no histórico do IAV e o que fizemos para permanecer de pé em meio à pandemia do Coronavirus é que trazemos 5 antídotos importantes para que você possa passar por crises. Você pode ouvir também pelo nosso canal no Youtube: https://youtu.be/oBJv4NIv-Lo Nos siga pelo Instagram: https://www.instagram.com/iavdesenvolvimento/

Welcome to the Great Women in Compliance Podcast, co-hosted by Lisa Fine and Mary Shirley.  While there are a lot of women in the field of Ethics and Compliance, there are fewer women who are in forensic risk analysis. Today, Lisa speaks with one of the pioneers in this area, Frances McLeod. Frances is an owner and Founding Partner of Forensic Risk Alliance (FRA) and head of its US offices. She has worked in many areas - data privacy and GDPR, as a monitor in many different matters for the SEC and DOJ and has focused a lot on sanctions as of late. Frances shares her experiences in growing FRA and her commitment to diversity in the field, as well as supporting and empowering women in their careers. She also talks about her experiences in very different monitorships - from being "the data lady" in the City of Ferguson matter, to her recent involvement in the IAV monitorships. We also discuss what compliance officers should be thinking about as Artificial Intelligence grows in importance for all of us. You can subscribe to the Great Women in Compliance podcast on any podcast player by searching for it and we welcome new subscribers to our podcast which is hosted on the Compliance Podcast Network. Lisa and Mary have extended the Great Women in Compliance brand to the booking “Sending the Elevator Back Down: What We’ve Learned from Great Women in Compliance” (CCI Press, 2020) which can be found on Amazon and features valuable wisdom and advice from Great Women in Compliance across the world. If you’ve already read the booked and liked it, will you help out other women to make the decision to leverage off the tips and advice given by rating the book and giving it a glowing review on Amazon?  As always we are so grateful for all of your support and if you have any feedback or suggestions for our 2021 line up, or would just like to reach out and say hello, we always welcome hearing from our listeners. Join the Great Women in Compliance community on LinkedIn here.

No livro bíblico Gêneses, Eloim, criou tudo do nada. Desde o momento em que Ele disse “Fiat Lux”, haja luz, a porra toda não parou mais. Teve montanha, mar, bicho, floresta, pernilongo, Adão, Eva, serpente, paraíso, pecado, dilúvio, irmão matando irmão, pai matando filho, Joelma do Calypso, Silas Malafaia, Bolsonaro, só a Covid já estamos na décima nona edição...uma loucura só. Eloim, também conhecido como Iavé, Jeová, Deus e outras alcunhas, segundo contam saiu de cena para descansar no sétimo dia. O job durou só seis dias e aquele do qual o homem é a imagem e semelhança, saiu para descansar no sétimo e nunca mais voltou. Mandou o filho, deu ruim pro pupilo, foi julgado, esculachado, crucificado, morreu, ressuscitou no terceiro dia só para constar. Partiu, está sentado ao lado direito do Pai e também nunca mais apareceu para um rolê por esta bocada chamada Terra. Passados alguns bilhões de anos desde da criação de tudo e da aposentadoria precoce do Eloim; e só depois de 2020 anos desde que o Jr esteve por aqui, só aí, enfim, em 16 de janeiro do ano que se finda, foi ao ar o primeiro episódio do podcast “Por uma vida menos ordinária”. Seus criadores continuam acreditando serem parentes do macaco e não da mesma forma de Adão e também, ao contrário de Eloim, ainda não descansaram mesmo após 35 programas. Hoje, estamos aqui para fazer um balanço do ano sob a perspectiva sempre criativa e que faz luz, faz fogo, faz graça e polemiza. Sugestões do episódio: PODCAST - Guilhotina #97 – José Paulo Netto: https://bityli.com/jPf5F FILME - Tio Frank: https://bityli.com/eDZm0 PODCAST - Brasil institucional vive em guerra com a brasilidade, diz Luiz Simas: https://bityli.com/eEzYR FILME - A Incrível História da Ilha das Rosas: https://bityli.com/5fKxQ DOCUMENTÁRIO - Emicida: AmarElo - É Tudo Pra Ontem: https://bityli.com/LpRWt

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.25.354381v1?rss=1 Authors: Honda, S., Minagawa, Y., Noji, H., Tabata, K. V. Abstract: Single-molecule experiments have been helping us to get deeper inside biological phenomena by illuminating how individual molecules actually work. Digital bioassay, in which analyte molecules are individually confined in small compartments to be analyzed, is an emerging technology in single-molecule biology and applies to various biological entities (e.g., cells and virus particles). However, digital bioassay is not compatible with multi-conditional or multi-parametric assays, hindering understanding of analytes. This is because current digital bioassay lacks a repeatable solution-exchange system that keeps analytes inside compartments. To address this challenge, we developed a new digital bioassay platform with easy solution exchanges, called multi-dimensional (MD) digital bioassay, and tested its quantitativity and utility. We immobilized single analytes in arrayed femtoliter (10-15 L) reactors and sealed them with airflow. The solution in each reactor was stable and showed no cross-talk via solution leakage for more than 2 h, and over 30 rounds of perfect solution exchanges were successfully performed. To show the utility of our system, we investigated neuraminidase inhibitor (NAI) sensitivity on single influenza A virus (IAV) particles in a multi-conditional assay. We proved that IAV particles show a heterogeneous response to the NAI. Further, to demonstrate multi-parametric assays, we examined the sensitivity of individual IAV particles or model enzyme molecules to two different inhibitors. Our results support that MD digital bioassay is a versatile platform to unveil heterogeneities of biological entities in unprecedented resolution. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.14.251132v1?rss=1 Authors: Kaler, L., Iverson, E., Bader, S., Song, D., Scull, M. A., Duncan, G. Abstract: In this study, influenza A virus (IAV) and nanoparticle diffusion in human airway mucus was quantified using fluorescent video microscopy and multiple particle tracking. In previous work, it was determined that mucin-associated sialic acid acts as a decoy receptor for IAV hemagglutinin binding, and that virus passage through the mucus gel layer is facilitated through the sialic-acid cleaving enzyme, neuraminidase (NA), also present on the IAV envelope. However, our data suggests the mobility of IAV in mucus is significantly influenced by the mesh structure of the gel, as measured by nanoparticle probes, and NA activity is not required to facilitate virus passage through mucus gels. Using newly developed analyses, the binding affinity of IAV to the 3D mucus meshwork was estimated for individual virions with dissociation constants in the mM range, indicative of weak and reversible IAV-mucus interactions. We also found IAV diffusion significantly increased in mucus when treated with a mucolytic agent to break mucin-mucin disulfide bonds. In addition, IAV diffusion was significantly limited in a synthetic mucus model as crosslink density was systematically increased and network pore size was reduced. The results of this work provide important insights on how the balance of adhesive and physical barrier properties of mucus influence the dissemination of IAV within the lung microenvironment. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.245225v1?rss=1 Authors: de Rozieres, C. M., Joseph, S. Abstract: Influenza A virus (IAV) is a highly contagious human pathogen responsible for nearly half a million deaths each year. Non-structural protein 1 (NS1) is a crucial protein expressed by IAV to evade the host immune system. Additionally, NS1 has been proposed to stimulate translation because of its ability to bind poly(A) binding protein 1 (PABP1) and eukaryotic initiation factor 4G (eIF4G). We analyzed the interaction of NS1 with PABP1 using quantitative techniques. Our studies show that NS1 binds as a homodimer to PABP1, and this interaction is conserved across different IAV strains. Unexpectedly, NS1 does not bind to PABP1 that is bound to poly(A) RNA. Instead, NS1 only binds to PABP1 free of RNA, suggesting that translation stimulation does not occur by NS1 interacting with the PABP1 molecule attached to the mRNA 3'-poly(A) tail. We propose that NS1 binds to the eIF4G complex at the 5'-end of the mRNA and recruits the RNA-free PABP1, which may stimulate translation initiation by promoting the association of the ribosomal subunits. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.238279v1?rss=1 Authors: Zeller, M. A., Gauger, P. C., Arendsee, Z. W., Souza, C. K., Vincent, A. L., Anderson, T. K. Abstract: The antigenic diversity of influenza A virus (IAV) circulating in swine challenges the development of effective vaccines, increasing zoonotic threat and pandemic potential. High throughput sequencing technologies are able to quantify IAV genetic diversity, but there are no accurate approaches to adequately describe antigenic phenotypes. This study evaluated an ensemble of non-linear regression models to estimate virus phenotype from genotype. Regression models were trained with a phenotypic dataset of pairwise hemagglutination inhibition (HI) assays, using genetic sequence identity and pairwise amino acid mutations as predictor features. The model identified amino acid identity, ranked the relative importance of mutations in the hemagglutinin (HA) protein, and demonstrated good prediction accuracy. Four previously untested IAV strains were selected to experimentally validate model predictions by HI assays. Error between predicted and measured distances of uncharacterized strains were 0.34, 0.70, 2.19, and 0.17 antigenic units. These empirically trained regression models can be used to estimate antigenic distances between different strains of IAV in swine using sequence data. By ranking the importance of mutations in the HA, we provide criteria for identifying antigenically advanced IAV strains that may not be controlled by existing vaccines and can inform strain updates to vaccines to better control this pathogen. Copy rights belong to original authors. Visit the link for more info

Pedro Augusto do Prado Pizarro Maciel Engenharia 1 e 2, 2012 - 2016 Irmão do João Maciel (Ep.01), foi responsável pelo sistema de freios nos primeiros anos, e simulação do motor no GT Power nos últimos. Hoje trabalha na IAV, na Fiat, na calibração de câmbios.

Bienvenida al episodio 23, esta semana vuelvo con una mesa redonda especial: la que hice con los colaboradores del IAV. Ellos son especialistas en diversas áreas del mundo de los negocios digitales y con ellos hablé de la evolución de este nuevo paradigma laboral.Seguro que puedes aprender mucho de sus respuestas y su experiencia va a sorprenderte. ¡Ah! Y recuerda: No dejes de escuchar este podcast y de compartirlo con otras personas a las que creas que les puede interesar, porque juntas vamos a sacar del coma a nuestra maravillosa profesión.

Na bagagem trabalhos com Scott Stapp (Creed), Rhapsody, Behemoth, Irmãos Cavalera, Glória, Fresno e muitos outros grandes artistas nacionais e internacionais. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ Recebemos dessa vez para um bate papo um dos maiores técnicos de som da nossa cidade, Dener Pereira, profissional formado pela IAV (instituto de áudio e vídeo), que nos contará sobre a grande importância desse profissional no mundo da música, sobre sua carreira de sucesso, além dos desafios, histórias e muitas dicas para os músicos de plantão e entusiastas. https://linktr.ee/guiadorockguarulhos

Thursday May 30, 2019 IAV to Pay $35 Million Criminal Penalty for Role in VW Emissions Fraud

On the first show of 2019 the chaps start with some Follow Up. VW is being sued by a German State Government, IAV pleads guilty in the US in connection with #Dieselgate, Ghosn is rearrested, two senior Nissan execs take some leave, Ghosn appears in court to refute claims against him, December and 2018 New Car Registrations are down, New Year's Honours for some special car people, London launches a van scrappage scheme, Tottenham Court Road to ban all but buses and bikes from March, Greater Manchester may bring in charges for LGV and HGVs, BMW to face criminal proceedings in Korea, Takata airbag recall still slow in the UK, Highways England doesn't like touchscreens in cars, Formula E is back at the weekend and so is the Rookie Test, Hyundai WRC gets a new boss, an excellent Lunchtime Read from Jalopnik and the cars and props from Fast and Furious Live are up for auction.

Der zweite Teil gibt vertiefende Einblicke in die Verwendung von VR im Umfeld von iAV.

Braucht es immer einen offziellen Projektstart? Koenig denkt, dass das Schwätzchen am Kopierer ausreichend ist. Stein denkt da anders. Zu Gast diesmal: Veit Lemke, Executive Projektleiter bei der IAV.  

SwineCast 0890 Show Notes: In part 2 of this series on IAV, the Morrison Group is joined by UMN's Dr. Montse Torremorell for a review of influenza research and herd spread learnings. Link to part 1 of this series.

SESCOM® Professional Media Interface For iPhone / iPad / iPod Mobile Media Devices Portable media devices and smart phones have come a long way since it's the basic initial introduction in 2001 with Apple's iPod. Today the technology has advanced with devices like the iPad, the iPhone and iPod Touch which can capture HD Video and amazing digital photos. These devices are finding their way into the presentation and conference rooms in businesses worldwide on an ever increasing level. The major problem has been how to handle the Audio-Video information in a format that can easily integrate in real time to a projector or large video audio display or TV! Sescom has chosen to develop the ultimate hardware solution for this: The SES-IAV is the answer. The video and audio media files you play on your mobile device can now be sent to your component video display and recording devices. Housed in a single 1RU rack mount enclosure, the iAV allows the user to connect the iPhone, iPad or iPod via included media cable and decodes the signal to broadcast Component Video with Balanced Audio. The iAV features dual outputs located on the front of the device for direct machine-to-machine connections, as well as a rear output group for rack interface with standard patch bays and control equipment. BNC connectors are used for true component video and Balanced XLR connectors for audio. Control of the audio level is also provided for with front panel level controls. The iAV will also provide charging for your compatible device via a built-in charging circuit. Powered by an included switch mode 110/220 VAC to 12 Volt DC adapter, the iAV can be easily adapted to mobile environments since the power jack is a standard 4pin XLR interface. Now you can easily use the iPhone with your TriCaster as both a camera and a media player. The Sescom iAV is a smart and practical solution to your broadcast and professional media applications. Specifications: Compatible Devices: The SES-iAV is a dual output audio and component video output solution for any iPad, iPhone & iPod that plays video, including, iPad, iPhone 4, iPhone 3GS, iPhone 3G, iPhone, iPod touch (Gen 1, 2, 3 and 4), iPod nano (Gen 3, 4, 5 and 6), iPod classic, iPod with video (Gen 5). Outputs: -Audio & video: 2 Component Video: Y/R-Y/B Y -- 1Vpp into 75 ohms R-Y-- .7Vpp into 75 ohms B-Y-- .7Vpp into 75 ohms 2 Balanced 600 ohm audio: 3pin Male XLR Control: -Audio Level: Gain 0 to +8db: independent both channels -Power: 12VDC@ 1A: 110/220 Auto switching to 12VDC power pack Power connector: standard 4pin XLR male Can be powered by any regulated 12VDC power source Dimensions: EIA Rack mount: 1.75"H x 5.0"D x 19"W Accessories: 12VDC power pack Multi-Pin extension cable to HD15 D-Sub Options: Extend the connection cable with any standard high resolution capable VGA male to female cable up to a distance of 25 feet