Podcasts about Kirs

  • 34PODCASTS
  • 60EPISODES
  • 59mAVG DURATION
  • 1MONTHLY NEW EPISODE
  • May 4, 2025LATEST

POPULARITY

20172018201920202021202220232024


Best podcasts about Kirs

Latest podcast episodes about Kirs

I Remember Liking That Movie Podcast
Drop Dead Gorgeous (1999) Welcome to the World of Beaty Pageants & Clever Politically Incorrectness

I Remember Liking That Movie Podcast

Play Episode Listen Later May 4, 2025 72:10


Send us a textDo you remember Drop Dead Gorgeous from 1999? We do and we don't. We remember that it has a stacked cast in Kristen Dunst, Denise Richards, Ellen Barkin, Kirstie Alley, Britney Murphy, Amy Adams & Allison Janney just to name a few. Seriously, there is a lot more. We also remember it being hilarious. We also think that hilarity might be very politically incorrect now. Either way, we couldn't be more excited. So join us as we go back to the end of the 90s and watch this documentary-style comedy. Do You Remember Liking This Movie?

Yamshayin Podcast
Season 4: Episode 1 - YOU HIT SOMEONE?!

Yamshayin Podcast

Play Episode Listen Later Apr 9, 2025 136:00


The Boyz are back for Season 4!! Talking all things informative, conspiracy, finances and music! Kirs lets us know you can't believe everything you hear, Spit talks hitting someone with a car, Brix talks AI and so much more on this weeks hit a crackhead filled episode of the Free Ain't Free Podcast!!

Bauherr werden - dein Podcast rund ums Bauen - Vermeide hohe Kosten, Baufehler und Pfusch am Bau und lerne hier die Grundlage
235-Haus aus den 70gern umrüsten mit der Vaillant Wärmepumpe (mit Manfred & Kirs)

Bauherr werden - dein Podcast rund ums Bauen - Vermeide hohe Kosten, Baufehler und Pfusch am Bau und lerne hier die Grundlage

Play Episode Listen Later Jun 5, 2024 52:32


Willkommen zur neuesten Folge von "Bauherr werden" mit dem spannenden Interview zwischen Maxim Winkler und den Gästen Manfred und Kris Vaillant! Diskutiert werden typische Sorgen und Mythen rund um Wärmepumpen, z.B. Vorlauftemperaturen, Stromverbrauch und die Integration in alte Gebäude wie Manfreds Fertighaus von 1974. Erfahre, wie eine sorgfältige Planung mit Energieberatern und die richtige Platzierung von Innen- und Außengeräten zur optimalen Nutzung beitragen können. Verpass nicht die wertvollen Tipps zur energieeffizienten Sanierung und die Zukunftsaussichten für CO2-neutrale Heizlösungen. Tune in und bleib informiert über moderne Heiztechnologien und nachhaltige Lösungen!

KRDO Newsradio 105.5 FM, 1240 AM 92.5 FM
Coach Kirs Mayotte - December 7, 2023 - KRDO's Morning News

KRDO Newsradio 105.5 FM, 1240 AM 92.5 FM

Play Episode Listen Later Dec 7, 2023 3:58


Colorado College Hockey Coach Kris Mayotte previews their games against the North Dakota Fighting Hawks.

KRDO Newsradio 105.5 FM • 1240 AM • 92.5 FM
Coach Kirs Mayotte - December 7, 2023 - KRDO's Morning News

KRDO Newsradio 105.5 FM • 1240 AM • 92.5 FM

Play Episode Listen Later Dec 7, 2023 3:58


Colorado College Hockey Coach Kris Mayotte previews their games against the North Dakota Fighting Hawks.

The GallowgateShots Podcast
Match Reaction | Newcastle United 2-0 Burnley

The GallowgateShots Podcast

Play Episode Listen Later Oct 1, 2023 39:26


Kirs, Scott and Daryl give us their reaction to the 2-0 victory against Burnley Want more GallowgateShots content? Then why not become a member of the channel for as little as £2.99 per month; you'll gain early access to videos; extra member only perks along with a link which will allow you to join our very own NUFC community via our telegram messenger group. Sign up below https://www.youtube.com/channel/UCWLHhMdZOBv6BGYU9aWVNjQ/join Follow our other social media platforms by clicking the link https://linktr.ee/gallowgateshots #NUFC #Newcastle #PremierLeague #NewcastleUnited #Podcast #NEWBUR Learn more about your ad choices. Visit megaphone.fm/adchoices

Yamshayin Podcast
Season 3: Episode 16 - Weirdo Shit 0_0

Yamshayin Podcast

Play Episode Listen Later Sep 2, 2023 69:34


The Boyz are back and talking all things informative, conspiracy, finances and music! Kirs lets us know T-Pain can rap rap, Spit talks about Grand Turismo, Brix talks Mexico and so much more on this weeks weirdo filled episode of the Free Ain't Free Podcast!! Don't forget to join us live on Twitch every Sunday night to be a part of the Free Ain't Free Podcast LIVE!! ---> https://www.twitch.tv/freeaintfree --- Send in a voice message: https://podcasters.spotify.com/pod/show/freeaintfree/message Support this podcast: https://podcasters.spotify.com/pod/show/freeaintfree/support

Vikerhommiku intervjuud
Kersti Kirs. Eesti kultuur vallutab Inglismaad

Vikerhommiku intervjuud

Play Episode Listen Later May 21, 2023 13:43


The Diversity of Me; Keeping It Real
Carrie - Co-Director Rise and Rise Up Academy

The Diversity of Me; Keeping It Real

Play Episode Listen Later Mar 22, 2023 34:08


Carrie is a global leader for diversity, equality and inclusion across the media technology industry with over 20 years' experience. She has built the international diversity membership organisation ‘Rise' and the ‘Rise Up Academy' from an initial idea and passion project to a thriving not-for-profit business working with brands such as BT Sport, ITV, Sky, Warner Bros.Discovery and others. Carrie has developed and delivered commercial business strategies and secured high profile partnerships for educational institutions such as Ravensbourne University London. She was given the Broadcast Tech Special Recognition Award in 2021 and won Gold for Female Leader at the UK's National Business Women's Awards also in 2021.Her x3 KIRs are aligned with Rise's mission

Yamshayin Podcast
Season 3: Episode 4 - Technical Difficulties (Please Stand By)

Yamshayin Podcast

Play Episode Listen Later Mar 1, 2023 66:18


The Boyz are back with ALOT of technical difficulties.. Kirs tried to upgrade the studio and screwed up the studio while upgrading. Brix upgraded the OBS streaming laptop and screwed it up in the process. Spittcasso judges us for fucking everything up. BUT we got it off the ground and gave y'all an hours worth of stoners rambling about current news on this weeks episode of the FREE AIN'T FREE Podcast!! Don't forget to join us live on Twitch every Sunday night to be a part of the Free Ain't Free Podcast LIVE!! ---> https://www.twitch.tv/freeaintfree --- Send in a voice message: https://anchor.fm/freeaintfree/message Support this podcast: https://anchor.fm/freeaintfree/support

Yamshayin Podcast
Season 3: Episode 3 - You Bet On The Eagles? SMH

Yamshayin Podcast

Play Episode Listen Later Feb 27, 2023 126:58


On the newest episode of the FREE AIN'T FREE Podcast, Spitty gets a nice lil payday, Kirs explains why Brix lost all his money betting on the Eagles in the Super Bowl, we ask the hard hitting questions such as, Rihanna pregnant? is Chris Brown still a woman beater? Whats up with the UFO's getting shot down? Project Blue Beam? Are we a hindrance to our own progression? All this and more on the newest episode of the FREE AIN'T FREE Podcast!! Don't forget to join us live on Twitch every Sunday night to be a part of the Free Ain't Free Podcast LIVE!! ---> https://www.twitch.tv/freeaintfree --- Send in a voice message: https://anchor.fm/freeaintfree/message Support this podcast: https://anchor.fm/freeaintfree/support

Kogumispäevik
#76 Näitlejad Klaudia Tiitsmaa ja Vallo Kirs - kuidas loomeinimesena rahaasjadega toime tulla?

Kogumispäevik

Play Episode Listen Later Jan 26, 2023 71:52


Seekord olid stuudios andekad Ugala teatri näitlejad Klaudia ja Vallo, kes rääkisid avalikult oma rahaasjadest, näitlejatööst ja pereelust. Samuti saad teada, mida nad avastasid, kui hakkasid eelarvet tegema ja kuidas sobituvad loomeinimesed ja numbrid. Saatejuht Mari-Liis Jääger

People First Radio
Tsqelmucwilc: we return to being human again – sharing the stories of survivors of the Kamloops Indian Residential School

People First Radio

Play Episode Listen Later Oct 22, 2022 27:58


Celia Haig-Brown and Randy Fred recently finished a tour to promote Tsqelmucwilc, a book that shares the testimonies of survivors of the Kamloops Indian Residential School. Tsqelmucwilc is a Secwepemc phrase that loosely translates to “we return to being human again”. The book builds on Haig-Brown and Fred’s work in Resistance and Renewal a 1988 book […]

Yamshayin Podcast
Season 2: Episode 18 - Bees Nees

Yamshayin Podcast

Play Episode Listen Later Oct 11, 2022 114:14


What a week! The Boyz talk their new EP releasing October 18th and their travels around the globe from New York to Mexico! Kirs came back a Spanish speaking legend? Spit came back with some wild tales of Americas oldest big city! Brix still hasn't finished the Dahmer show on Netflix but tells us all about the 3 movies he won't fall asleep during. The chat on Twitch got wild this week, lots of questions and interaction! Thank you to everyone who's been a part of the live streams! If you'd like to join us live, follow us on Twitch ---> https://www.twitch.tv/freeaintfree --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/freeaintfree/message

Yamshayin Podcast
Season 2: Episode 15 - Mexican Twins?

Yamshayin Podcast

Play Episode Listen Later Sep 12, 2022 134:01


The Boyz are back!! Have you ever met identical Mexican twins? Conspiracy theories are only conspiracies until they are true says Kirs. Spitcasso takes a few bathroom breaks and tells us about his newly broken finger (which is why we missed a week of the podcast). Brix updates us on the Crypto market. Rappers not paying producers, The MCU, jungle couches and much much more on this weeks episode of the Free Ain't Free Podcast!! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/freeaintfree/message

The Diversity of Me; Keeping It Real
Suzie - TV personality, Speaker, Voice Over Actor

The Diversity of Me; Keeping It Real

Play Episode Listen Later Aug 31, 2022 44:03


Suzie Cox is many things…. a TV personality and speaker, a voice over actor, a mentor, investor and advocate, a fellow podcaster, a mum and she was Vogue off of Gladiators, as in the hit TV show of the 90s that I watched religiously every weekend…I cannot believe I have the actual Vogue off of the actual Gladiators on my podcast!She has presented and been interviewed on numerous regional and national television and radio shows including ITV, LWT, BBC, Channel 4, Virgin Radio and Radio 5 Live. She does a whole host of voice over acting and narration and she has not one but TWO podcasts; Top Dogs and Their Humans where Suzie chats with some amazing humans about their pooches and Brave Pants with Vogue and the Viking which is all about women putting on Brave Pants and doing stuff they have always wanted.Her x3 KIRs are:1️⃣  Needing quiet time

The Diversity of Me; Keeping It Real
Minreet - Award-Winning Freelance Journalist

The Diversity of Me; Keeping It Real

Play Episode Listen Later Aug 24, 2022 50:42


Minreet Kaur is an award winning freelance journalist working across TV, Radio and Online. She is also the daughter of 75 year old Rajinder Singh, known as The Skipping Sikh, where in 2020 during the height of the global pandemic, he shared exercise videos to inspire older members of the South Asian community to stay healthy whilst also raising money for the NHS. He was subsequently awarded an MBE and Minreet has helped to share his story through many news outlets.Minreet has written for the independent, BBC, Sky, Stylist, Byline Times, Metro, iPaper, Guardian and Al Jazeera. She has also reported for The One Show, Newsround, Sunday Morning Live, BBC South and Sky News.Her work focuses on improving the representation of South Asian communities and she has written features, opinion and news pieces.Her x3 KIRs are

The Diversity of Me; Keeping It Real
Caroline Ewerton - VP Technical Production Management, DAZN

The Diversity of Me; Keeping It Real

Play Episode Listen Later Aug 17, 2022 42:50


Caroline Ewerton is Vice President of Technical Product Management, leading the transformation, next generation and optimisation of the media supply chain at DAZN. DAZN is a global sports entertainment streaming platform, streaming nearly 1 billion hours of live sport every year in over 200 countries and territories. She joined DAZN as Head of Operational Delivery in 2019 and at the end of 2020 she became Vice President of Production Services before moving into her current role.In the short time that I've got to know her by asking her to be a guest on my podcast, I find her to be warm, kind and someone who possesses a level of self-awareness that is truly admirable and I have no doubt after listening to her talk about her three Keeping It Reals, you too listener will agree with me!Carolines x3 KIRs are

The Diversity of Me; Keeping It Real
Chase - Assistant Producer, BBC Natural History Unit

The Diversity of Me; Keeping It Real

Play Episode Listen Later Aug 3, 2022 58:29


Chase has always had dual passions in wildlife and creativity and as a child they would make films impersonating Steve Irwin! Chase went on to study Zoology at the Universities of Exeter and Calgary, whilst exploring the arts during any spare time they had. They only became aware of the roles and career opportunities in Natural History Filmmaking through the Creative Access Internship Scheme - and soon realised that they wanted to create a flourishing career in this industry.We met just over a year ago when I was working at Wildscreen to help launch their Emerging Talent Scheme and I had sourced Chase as a speaker. I've basically ripped off the bio I wrote for them back then for this podcast! Anyway, we followed each on the gram and kinda got to know each that way, we met for dinner ahead of this recording and I now consider them to be a friend.Their top 3 KIRS:1️⃣ Unlearning is just as important as learning2️⃣ Your differences are your greatest strengths3️⃣ Don't forget to enjoy the viewIntro & outro music credit: Dawn Awaits by Cody Martin, obtained from www.soundstripe.comI'm on social if you're interested…primarily Insta and occasionally Twitter: @diversityofme 

HRM-Podcast
Digitale Kunden- und Mitarbeitergewinnung mit System I Mittelstand I Industrie I Produktionsunternehmen I B2B-Unternehmen I B2B-Vertrieb I Marketing: #052 - Robert Kirs packt aus: Die Wahrheit über Kundengewinnung im Mittelstand

HRM-Podcast

Play Episode Listen Later Jul 5, 2022 16:31


Für viele Geschäftsführer im Mittelstand immer noch ein Buch mit sieben Siegeln: das Thema Social Media. In dieser Folge entschlüsseln wir: Welche Rolle spielen die Social Media für mittelständische Unternehmen?Welche Social Media sind überhaupt für mittelständische Unternehmen geeignet?Welche Ergebnisse kann man mit hilfe der Social Media erreichen? Welche Vorteile bringen die Social Media gegenüber den herkömmlichen Wegen der Kommunikation?Welchen Nachteil hat das Vorgehen über Social Media?

HRM-Podcast
Digitale Kunden- und Mitarbeitergewinnung mit System I Mittelstand I Industrie I produzierendes Gewerbe I B2B Unternehmen I B2B Vertrieb I Marketing: #052 - Robert Kirs packt aus: Die Wahrheit über Kundengewinnung im Mittelstand

HRM-Podcast

Play Episode Listen Later Jul 5, 2022 16:31


Für viele Geschäftsführer im Mittelstand immer noch ein Buch mit sieben Siegeln: das Thema Social Media. In dieser Folge entschlüsseln wir: Welche Rolle spielen die Social Media für mittelständische Unternehmen?Welche Social Media sind überhaupt für mittelständische Unternehmen geeignet?Welche Ergebnisse kann man mit hilfe der Social Media erreichen? Welche Vorteile bringen die Social Media gegenüber den herkömmlichen Wegen der Kommunikation?Welchen Nachteil hat das Vorgehen über Social Media?

The New Statesman Podcast
Farewell to a legend: Tears, cheers and kirs

The New Statesman Podcast

Play Episode Listen Later Feb 18, 2022 40:23


Anoosh Chakelian and Ailbhe Rea host a special episode to say goodbye to Stephen Bush. Kir royales are sunk and Stephen takes an audio trip down memory lane, featuring a rendition of “American Pie”, this time about Scottish Labour, as well as his teenage Harry Potter fanfiction and his honest opinion on “Devil with the Devil”. Then in You Ask Us, former hosts make a special appearance to ask Stephen some questions. See acast.com/privacy for privacy and opt-out information.

The Miniature Podcast
Painting Competitions are Subjective, Make Them Showcases Instead -- Kris Belleau

The Miniature Podcast

Play Episode Listen Later Dec 21, 2021 123:37


Kris has been in this hobby since the late 1980s thanks to some of his older cousins and the first edition of Space Hulk. Ever since that first game, he's been painting and hobbing almost exclusively with Warhammer miniatures and games. Kris ended up working for Miniwargaing during the 2010s as the painting instructor for their content creation team which really launched his career as an educator in the miniature painting hobby.Miniatures and miniature painting have been a huge part of his hobby, and canvas painting has been a massive part of Kris' art. We have a great discussion about Kris' perspective on miniatures and art, and whether or not miniatures can be art that stands the test of time or not.We also dive into what it means to be a full-time miniature painting educator and what impact that has on Kirs' ability to improve and develop his own skills.- https://www.wayofthebrush.com/- https://www.twitch.tv/wayofthebrush- https://www.instagram.com/kris.belleau/- https://www.facebook.com/wayofthebrush/- https://twitter.com/KrisBelleauThese interviews are recorded live at Twitch.tv/Uselesswizard. Check the stream schedule there for the next recording date and time.You can join me, Uselesswizard, on Tuesdays and Fridays nights at 6pm Pacific. We have a wonderful, supportive, and welcoming community of people and we'd love to see you.If you'd like to help support or improve the show, please leave a review on our page in Apple Podcasts or our page on Podchaser. Reviews have a big impact on whether the show is recommended to others, and it would mean the absolute world to hear from you.Thanks for listening!The Miniature Podcast TwitterCheck out Uselesswizard's Twitch Channel to see interviews recorded liveVisit Uselesswizard's Instagram page to see what he's been paintingSee Uselesswizard's Twitter for the non-toxic side of the TwitterverseIntro and Outro Music"No.4 Piano Journey" by Esther AbramiYouTube Audio Library

GEWINNERpodcast
#026 Robert Kirs im Interview: "Online-Marketing für den deutschen Mittelstand."

GEWINNERpodcast

Play Episode Listen Later Nov 25, 2021 29:57


Besuche für weitere spannende Storys das GEWINNERmagazin: www.gewinnermagazin.de und abonniere diesen Podcast. In der heutigen Episode des GEWINNERpodcasts spricht Ruben Schäfer mit Robert Kirs, dem Geschäftsführer der Social Media Schwaben GmbH darüber, wie Online-Marketing speziell für den deutschen Mittelstand funktioniert & was dabei zu beachten ist. Besuche jetzt für weitere spannende Storys das GEWINNERmagazin: www.gewinnermagazin.de Im GEWINNERpodcast mit Chefredakteur Ruben Schäfer lernst du, was erfolgreiche Unternehmer und Persönlichkeiten auszeichnet. Wir werfen einen Blick hinter die Kulissen von erfolgreichen Menschen und verraten dir, wie sie wohlhabend wurden. Nutze ihre Geschichten und Learnings für deinen persönlichen Erfolg. Interessante Geschichten und Interviews, wöchentlich neu und inspirierend. Das ist dein GEWINNERpodcast.

Shit 90s Shows Taught Me | Boy Meets World / 90s TV
BONUS: Runaway Bride with Kirs

Shit 90s Shows Taught Me | Boy Meets World / 90s TV

Play Episode Listen Later Nov 20, 2021 97:36


Join Jessica Sterling (@thejesssterling) and Sara Fergenson (@sarafergenson) as they finish Julia Roberts month by chatting Runaway Bride with Kirs. They rank the wedding dresses and engagement rings, gush over Peggy Flemming and discuss how utterly ridiculous this movie is.Follow us on Twitter and Instagram at @shit90spod.Email us at shit90spod@gmail.comVisit our website at www.shit90spod.comAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Wombat Water
Full Dump (Coconut Water) with Sara, Kirs, Jonathan

Wombat Water

Play Episode Listen Later Oct 19, 2021 77:35


We're back with more water, and this one's tough to crack! Karen from Canada, Sara Fergenson, Kirs, and Jonathan go head to head to determine which coconut water is the best of them all! Corey B hosts. This episode was produced and edited by Corey B and Karen from Canada. Follow us on Twitter: https://twitter.com/wombatwater Visit our website: https://wombatwater.com/

The Diversity of Me; Keeping It Real
Dee - Aspiring film maker and Runner at Icon Films

The Diversity of Me; Keeping It Real

Play Episode Listen Later Jul 14, 2021 40:41


Shining a light on the next Generation Talent in the broadcast media industry... last episode of this series!Dee Hassan was someone I had interviewed for a Runner role whilst I was working at Icon Films. She was successful during the interview process and started her new position in February this year. I was really impressed by Dee when we first met - she has this quiet determination about her and I just know that whatever else she goes on to do in future, she will be absolutely brilliant at it! Her 'Keeping It Reals' led to a truly wonderful conversation with a young woman who is insightful beyond her years and that's because of her experiences as a Somali woman growing up in Sweden, having moved to the UK when she was 14 years old. Dee's x3 KIRs 1️⃣ Never compromise on your professional values 2️⃣ How can I be of benefit of a project and how can I benefit from it? 3️⃣ Big picture - does the work serve a worthwhile purpose?Links I said I'd share in the episode:https://www.creativeyouthnetwork.org.uk/dee-hassanhttps://www.rifemagazine.co.uk/author/deqa-hassan/https://www.rifemagazine.co.uk/2020/01/who-are-the-silent-voices-in-the-green-movement/13th Documentary: https://www.youtube.com/watch?v=krfcq5pF8u8Intro & outro music credit: Dawn Awaits by Cody Martin, obtained from www.soundstripe.com I'm on social if you're interested…primarily Insta and occasionally Twitter: @diversityofme

The Diversity of Me; Keeping It Real
Stefi - Scrum Master - NOW TV App at Sky

The Diversity of Me; Keeping It Real

Play Episode Listen Later Jul 7, 2021 45:08


Stefi Popescu is a Scrum Master for the NOW TV app at Sky. What's a Scrum Master? Well - it's the term to describe a person leading a team of software developers, to ask act as a facilitator and coach, a person who enables the team to work in a productive environment and removes any blockers. Stefi leads a team of front-end developers who look after the NOW TV app on TVs and gaming consoles. In addition to that, she is responsible for other management related tasks such as creating personal development plans for her team.Interesting fun fact - Stefi's hometown in Romania has less people in its population than the number of employees working for Sky - so Sky has around 25,000 employees and Stefi's home town has a population of just 16,000 in comparison!Her three x3 KIRs are

La escóbula de la brújula
Programa 389 - Curiosidades del ajedrez

La escóbula de la brújula

Play Episode Listen Later Jul 2, 2021 136:58


Es uno de los juegos más fascinantes de la historia, con orígenes inciertos. Conocer su historia y algunas curiosidades es lo que nos proproponemos de la mano de Alfonso Romero Holmes, maestro internacional de ajedrez, campeón de España en 1987 y editor, que nos hablará del primer tratado de ajedrez moderno que aparece en españa en el siglo XV y de anécdotas de grandes maestros como Bobby Fischer o Anatoli Karpov, a quien representa en exhibiciones de simultáneas y torneos. Rosa de las Nieves, periodista, fotógrafa y cronista de ajedrez, autora del cuento 'Leonor y el misterioso tablero de ajedrez', nos hablará de las hermanas Polgar, del duelo que mantuvieron Korchnoi y Karpov en Baguio en 1978 utilizando todo tipo de tretas parapsicológicas o la extraña historia de Kirsán Lliumzhinov, secuestrado por un ovni. Marcos Carrasco hablará sobre el artista Marcel Duchamp, habiendo ejecutado un jaque mate al arte con sus obras. Carmen Fernández nos hablará del ajedrecista mecánico de Leonardo Torres Quevedo, de la máquina Deep Blue y la versión del AlphaGo para ajedrez. Carlos Canales, además de hablar del autómata El Turco, el barón von Kempelen, nos dirá los 17 tipos de ajedrez que existen y el 'número de Shannon'. Juan Ignacio Cuesta sobre sus partidas online con el programa Fritz. David Sentinella recordará su faceta de jugador en la adolescencia y a dos grandes ajedrecistas: Gloria Velat y Pepita Ferrer. Pepa Llausas recomendará la película 'La reina de Catwe', sobre la vida de Phiona Mutesi. Y Jesús Callejo hará unas reflexiones sobre el libro de Gary Karparov, 'Cómo la vida imita al ajedrez'.

The Diversity of Me; Keeping It Real
Nali - Assistant Producer - Humble Bee Films

The Diversity of Me; Keeping It Real

Play Episode Listen Later Jun 30, 2021 49:27


Nalini Mistry is an Assistant Producer, based in Bristol, working in the wildlife film making industry. Since 2013 she has worked on landmarks and blue chip natural history content for digital and TV for the likes of the BBC and other major production companies. She has also worked on household favourites such as Springwatch and Countryfile.Her x3 KIRs:1️⃣ Enjoy what you do, and discover the things that surround your passions – doors will always open2️⃣ Don't give up, if you don't fit in somewhere it might not be the right environment. Keep going3️⃣ Accept you can't control everything, and accept changeIntro & outro music credit: Dawn Awaits by Cody Martin, obtained from www.soundstripe.comI'm on social if you're interested…primarily Insta and occasionally Twitter: @diversityofme

Redeye
Discovery of the remains of 215 children a national emergency

Redeye

Play Episode Listen Later Jun 27, 2021 17:36


After the remains of 215 children were found on the grounds of the old Kamloops Indian Residential School, there have been expressions of shock and grief, but also calls to action. Kukdookaa Terri Brown is a Crow Clan member of the Tahltan Nation. She is former chief of her people and former president of the Native Women's Association of Canada. She served 6 years with the Truth and Reconciliation Commission of Canada where she heard many stories of children going missing or not returning from residential schools.

The Diversity of Me; Keeping It Real
Elena - Production Manager, Humble Bee Films

The Diversity of Me; Keeping It Real

Play Episode Listen Later Jun 2, 2021 52:00


Humble Bee Films is an independent production company based in Bristol. In case you're not familiar with what a production manager does - they oversee the logistics of a TV production - booking travel and accommodation, arranging for equipment to be delivered on shoots, organising contributors, staffing for productions, health and safety on location, clearing rights - basically anything that involves organising.

The Proven Principles Hospitality Podcast
Diversity and Inclusivity in Hospitality - Vol. 2: Kirs Jay, Hotel Experience Coordinator

The Proven Principles Hospitality Podcast

Play Episode Listen Later May 12, 2021 41:47


This episode is brought to you by Wheelhouse - the best revenue management platform for vacation and short term rentals.  Learn more about Wheelhouse here ➡️ https://usewheelhouse.com Use code KNOWINGHOSPITALITY for 50% off your first month with Wheelhouse. --- Kírs is an Experience Coordinator at a luxury spa and hotel in Vancouver, British Columbia. Using their expertise and lived experience as a transgender and non-binary individual, they engage industry professionals in conversations regarding gender inclusivity with a focus in hospitality. After recording episode 43 with Daniel Poulin on Diversity and Inclusion, we got to talking about what D&I efforts were looking like on the ground, within hotels, not just at the corporate level. He introduced me to Kirs, who's been heavily involved on the D&I committee at their hotel, and our initial conversations about doing a follow up episode led to a fantastic show about what it's like for the employees tasked with delivering service day to day, how company efforts affect their ability to do their jobs, having sense of pride and belonging to one's workplace and the actions companies should be taking if they've made no movement yet. We're continuing the discussion about Diversity and Inclusion on this episode. As hotels start to rehire after the pandemic, there is no better time to be talking about how we want things to look going forward. On this episode we discuss: Kirs' involvement with the D&I committee at their hotel (5:38) Coming out to their workplace (7:31) How long it took for the D&I committee to form after coming out to their workplace (10:32) Company interaction standards (13:52) Companies may not know how to move forward, resulting in no action (15:22) One year in… where is the D&I committee today? (19:47) The pace of change from a committee member's perspective (24:58) Guest-centric vs. Employee-centric perspectives (29:14) Removing bias from everyday language (31:18) Bridging personal guest experiences and internal diversity efforts (32:59) The fear of having uncomfortable conversations (38:33) About Kirs Kírs is an Experience Coordinator at a luxury spa and hotel in Vancouver, British Columbia. Using their expertise and lived experience as a transgender and non-binary individual, they engage industry professionals in conversations regarding gender inclusivity with a focus in hospitality. Links Pulse iSpa Magazine: https://pulse.experienceispa.com/ (https://pulse.experienceispa.com/) Instagram (Kirs): https://instagram.com/kirsarthur?igshid=1ugw8ks46isou (https://instagram.com/kirsarthur) --- We want to hear from you! Send in a voice message or review to the podcast: https://anchor.fm/provenprinciples/message (https://anchor.fm/provenprinciples/message) --- Do you need to revamp your hospitality business strategy? Do you need help with a project or someone to work with on a tough problem in your hotel or restaurant? If I can help you in any way, please don't hesitate to reach out. You can book a free call with me by going to https://www.knowinghospitality.com/contact (knowinghospitality.com/contact)

Látszótér Rádió Budapest
Beszélgetés a bátorságról Kirs Eszterrel 2.

Látszótér Rádió Budapest

Play Episode Listen Later Mar 26, 2021 55:59


Egy beszélgetés második része, amiben szó lesz arról, mi a köze a szeretetnek a másokért való kiálláshoz, illetve hogy kell-e a második autó vagy a balatoni nyaraló.

Látszótér Rádió Budapest
Beszélgetés a bátorságról Kirs Eszterrel 1.

Látszótér Rádió Budapest

Play Episode Listen Later Mar 22, 2021 56:00


Egy beszélgetés első fele, amiben háborús bűnökről, emberi jogokról és civil kurázsiról is szó esik.

The Diversity of Me; Keeping It Real
Dershe - Co-Founder and Creative Director Nuwave Pictures

The Diversity of Me; Keeping It Real

Play Episode Listen Later Mar 17, 2021 45:35


Dershe Samaria is Co- Founder and Creative Director of Nuwave Pictures, who was announced one of ten ethnically diverse stand out indies alongside the likes of David Olusoga's Uplands, Romesh Ranganathan's Ranga Bee and Lenny Henry's Douglas Road to officially partner with Channel 4 and The TV Collective on the Indie Accelerator. Fast tracking their ideas to broadcast commission

The Diversity of Me; Keeping It Real
Steven - Storyteller & Audiobook Narrator

The Diversity of Me; Keeping It Real

Play Episode Listen Later Mar 10, 2021 59:26


Steven Jay Cohen describes himself as a storyteller. He narrates audiobooks and is also owner of Spoken Realms - an audio publishing business which is one of the largest producers of classic, public domain, literature on Audible, iTunes and Amazon. Spoken Realms has over 2500 titles to their credit and they help to connect storytellers from around the world with a global audience through the production of their audiobooks.Steven also sits on the Diversity Committee of the Audio Publishers Association and is on a mission to try and diversify the voices we hear in the audio publishing world. We met at The Creative Coalition event delivered by The Creative Industries Federation back in November 2020. He had posted a comment about the audio publishing industry looking for diverse voices! He shared some links (I'm looking into becoming an audio book narrator) and I then asked him to appear on my podcast! So here he is!His x3 KIRs are around his commitment to diversity in the audio publishing world, knowing that unlike other ethnically diverse people he has a choice as to whether or not he ‘can pass' and helping good people do good work.You can find out more about Steven here: https://www.spokenrealms.com/

Həyasız Kadınlar
#düşündüklərimiz Sən niyə film çəkirsən?

Həyasız Kadınlar

Play Episode Listen Later Feb 19, 2021 12:38


Bu dəfə rejissor Lalə Əliyeva ilə söhbətləşdik. Son filminin müzakirəsindən başladıq və sonra daha mücərrəd suallar fikrimizi yayındırdı. Lalənin “Onlar pıçıldayır, amma bəzən qışqırır “ filminin çarxını linkdə tapa bilərsiniz: Danışdığımız filmlər və kitablar: Carlos Reygadas “Post Tenebras Lux” Apichatpong Weerasethakul-un filmləri Alain Guiraudie “Strangers By The Lake” Аlexey Fedorchenko “Celestial Wives of the Meadow Mari” Sei Shonagon “The Pillow Book” Gaston Bachelard “The Poetics of Space”  “Каникулы в Простоквашино” cizgi filmi 

Wombat Water
Aural Experience (Candy) with Chappell, Michael J. Clark, Kirs

Wombat Water

Play Episode Listen Later Oct 24, 2020 189:21


Which candy is the reason for the season? Leading up to Halloween, we decided to put candy to our patented test to see which popular candy is the best! Chappell, Michael J. Clark (MJC), and Kirs join Karen from Canada for some spirited debates and ridiculous games that still somehow empirically determine the best candy! Which candy will rise to the top? Join us to find out! JD McGuire hosts. This episode was produced and edited by Corey B. Visit our website: https://wombatwater.com/ Follow us on Twitter: https://twitter.com/wombatwater

Hip Politics
The Connex Podcast Epi 9 - RIP John Lewis | Megan Thee Stallion & Tory Lanez | New DJ Khaled x Drake

Hip Politics

Play Episode Listen Later Jul 18, 2020 54:35


It is a sad day in America. This week we discuss the life and legacy of civil right icons Congressman John Lewis & Rev. C.T. Vivian who both passed away on July 17. We honor them with a moment of silence and explore their impact on civil rights movements of today. During the “Pass the Aux Cord” segment, we review the pair of records released by DJ Khaled featuring Drake. We offer some funny takes on the debate of which is better: rapping Drake of singing Drake? We end the episode into a full blown debate on Megan Thee Stallion being shot in the foot and try to decipher fact vs fiction as to what involvement artist Tory Lanez had in the whole thing. We do know he was arrested for having a concealed gun and letting off shots, but we ask: was he actually shooting a Hot Girl Meg. This is another hilarious yet informative episode of The Connex Podcast featuring funnyman Dwain Watts, culture critic Kirs, and our Congressional insider KP. Be sure to tune in every Saturday at 10:30 am EST to catch THE CONNEX PODCAST: Where Hip-Hop & Politics Meet. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/hippolitics/support

Hip Politics
Hip-Politics presents: The Connex - July 4th Quarantine Edition

Hip Politics

Play Episode Listen Later Jul 6, 2020 42:41


Tune in every week to The Connex Podcast featuring hilarious comedian Dwain Watts, culture commentator Kirs and Congressional insider KP. They tackle the top news in the world of Hip-Hop and Politics, review the latest songs and point out the biggest WTF? moments of the week.

The InnerFight Podcast
#620: Leveraging social media for humanity with Kris Fade

The InnerFight Podcast

Play Episode Listen Later Apr 9, 2020 45:39


If you live in Dubai then Kris Fade is certainly a name that you would know….the man behind the Virgin Radio breakfast show. If you don’t live in Dubai and to give this show some context Kris Fade moved to Dubai just over 10 years ago on a "whim and a prayer.” Since then with his team of presenters he has built the biggest breakfast radio show in the region. Not only that but Kris has risen as somewhat of a local social media star working with some top regional and global brands to drive home their messages. A highlight for Kris certainly has to be when he hosted the Pope in Abu Dhabi in 2019. If you have not heard Kris on the radio or seen him at an event then just hop over to his Instagram flick back a week or so and have a look at how he first offered up his platform to support local businesses during these challenging times. Truly remarkable. Kris continues to drive the message of leveraging his social media to help people that are having tough times right now and we discuss this more in this show as well as everything from “fear of the unknown” to “workouts are the cure.” Kirs has awesome energy and I am sure will give you all a lot of inspiration and some ideas. Enjoy the show.

CrossYaas: The Crossdress and Gender Appreciation Podcast
Crossdress and Tucking; Yaas Tucking

CrossYaas: The Crossdress and Gender Appreciation Podcast

Play Episode Listen Later Jan 21, 2020 36:46


In the first episode of 2020, Giselle talks about tucking. Episode 41’s Yaas of the Week is the gender neutral IDs in the United States and Kirsten Corner is all about Kirs’s purses! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/crossdress/support

Viljandi linnatund
Viljandi Linnatund: 10.10.2019 saates Allan Praats, Vallo Kirs, Margus Haav

Viljandi linnatund

Play Episode Listen Later Oct 10, 2019


10.10.2019 saates Allan Praats, Vallo Kirs, Margus Haav

Drive Time Lincoln
Guest Host Kirs Beckenbach welcomes Paul VonBehren to DTL.

Drive Time Lincoln

Play Episode Listen Later Jun 18, 2019 8:26


Kris continues the conversation about property tax relief with Paul VonBehren, leading an effort to gather signatures for a ballot measure.

Edmund Burke'i Selts
#32 Vallo Kirs ja Urmas Lennuk, "Eestlase evangeelium"

Edmund Burke'i Selts

Play Episode Listen Later Feb 14, 2019 102:41


"Tammsaare ei taha mulle, eestlasele, pakkuda ei päriseestlust ega õiget isamaad. Ta ei taha, et ma läheksin ja Jägala jõe Tammsaarel... alla laseksin ja sood ära kuivendaksin... Ta tahab pakkuda, ma olen selles täitsa veendunud, ei vähem ega rohkem kui evangeeliumi, lunastust. Tema, vana vindunud skeptik," kirjutab Tõnu Õnnepalu oma suurepärases essees "Tammsaare kui eestluse alustekst/eestlase pealistekk".Sarja 32. saates tulime eestlase evangeeliumi juurde jälle tagasi. Kui kevadel rääkisime ühes Tõnu ja Kaie Mihkelsoniga ("Vannutatud neitsi" (#16)* Tammsaare romaanist "Kõrboja peremees", siis 13. jaanuaril Kuku Raadio eetris kõlanud saates tuli jutuks Urmas Lennuki ja Vallo Kirsi suvelavastus "Kõrboja perenaine". Mõlemad viimatinimetatud olid sedapuhku ka stuudiokülalised. See acast.com/privacy for privacy and opt-out information.

Sports Social with Ed Easton Jr
Sports Social: Episode 102 “KIRS Reunion Part Two”

Sports Social with Ed Easton Jr

Play Episode Listen Later Oct 10, 2018 52:22


10/10/18 (S3-EP30) Sports Social with Ed Easton Jr featured part two of the KIRS Radio show reunion with a preview of the 2018-19 NBA season. Guest Twitter - @FunnyManStan (Stan Talouis), @PabloDollas (Danny Clase), @Haitian_Drizzy (Claude LaRoche Esq.) • Check out Keepingitrealsports.com and SportsSocialPod.com • Follow @EdEastonJr on Twitter/Instagram

Sports Social with Ed Easton Jr
Sports Social: Episode 101 “KIRS Reunion Part One”

Sports Social with Ed Easton Jr

Play Episode Listen Later Oct 3, 2018 50:44


10/3/18 (S3-EP29) Sports Social with Ed Easton Jr featured part one of the KIRS Radio show reunion with discussions over Colin Kaepernick’s Nike campaign and Le’Veon Bell’s holdout from the Pittsburgh Steelers. A look back at Serena Williams' US Open press conference discussing her emotional embrace with Naomi Osaka with both players crying. Williams says she wasn’t being coached and provides her perspective for what happened in the match. Guest Twitter - @FunnyManStan (Stan Talouis), @PabloDollas (Danny Clase), @Haitian_Drizzy (Claude LaRoche Esq.) • Check out Keepingitrealsports.com and SportsSocialPod.com • Follow @EdEastonJr on Twitter/Instagram

Lunken Kaffi
s11e04: Bildmakarna med Simon Lode

Lunken Kaffi

Play Episode Listen Later Jun 28, 2018


Tatt opp i Lunkent Verksted, 18.juni, 2018Den nylig uteksaminerte kunstskole studenten og utrolig produktive multikunstner Simon, sklir inn i verkstedet en sommeraften. Han forteller meg om sin dag, Fitnik, Lode trafikkskole, grafisk design, Kunstskolen i Rogaland, LUNKENT BEKJENTSKAP, produktivitet, hviledag, terapeutisk tegning, å være for illustrativ, Simon forteller om en stor grafisk jobb som ledet til at han måtte slutte med slike oppdrag, å ha jobb utenom det kreative, Simons ekstrajobb, Simon liker ikke varm drikke, vi går igjennom alle Simons forskjellige kreative håndverk, fargeblindhet, pornografiske malerier og instagram, hjemmeside, Simons fremtidsplaner, å sette ut skulpturer i det offentlige rom, Henrik Aa Uldalen, Simon sitt første prosjekt på KIR "En reiserute for aktiv dødshjelp", "Rotten bridges" fra PARA på Rogaland kunstsenter, å lese tekst på utstillinger i alko-rus, Simon skriver helst på engelsk, tekstene i Ouroboros katalogen, Ouroboros utstillingen og gjennomgang med kurator, å få tid til å gå på kunst åpninger, de ekstremt sosiale Air Sandnes kunstnerene, første klasse utstilling vs avgangsutstilling, å ikke ha alkohol på KIRs første års utstillingen, BERGMAN, å jobbe med alkohol i blodet, Simon forteller om hva han skal gjøre 7 uker i Kreta, å produsere mer en du har plass til, å jobbe med store formater, å bare vise et verk, KIRs mulige tredje år, Andreas Soma får kjærlighet. Simon vil virkelig satse på kunst, arbeidsstipend og hvordan å takle det å få og det å ikke få, å "pushe" hverandre, BrOslo, Simons møte med Martyn Reed, LUNKEN DAGBOK, SELVSKRYT, refleksjons sigging, å gå turer for kreativ inspirasjon, å bygge møbler, psykedelisk kunst, forbannelsen til George Dunning, promotering, Simons penis prosjekt, Aled George Pagler, så avslutter vi med litt vagt snakk om riving av Metropolis og kunsthuset på Nytorget,God Lytting!

Sports Social with Ed Easton Jr
Sports Social: Episode 71 “Booker’s Cereal & NY Giants Clean House”

Sports Social with Ed Easton Jr

Play Episode Listen Later Dec 5, 2017 52:04


12/5/17 (S2-EP19) Sports Social with Ed Easton Jr featured a full recap of the New York Giants drama surrounding Eli Manning’s benching as well as the firings of Ben McAdoo and Jerry Reese with KIRS correspondent Stan Talouis. Twitter - @FunnyManStan  I spoke with Brooklyn Nets forward Trevor Booker during his annual “Booker’s Breakfast Assist” event. All the cereal accumulated during this event went back to Bed-Stuy Campaign Against Hunger. Twitter - @35_Fitz Check out Keepingitrealsports.com & SportsSocialPod.com for more information

Brooklyn Free Speech Radio
Sports Social: Episode 71 “Booker’s Cereal & NY Giants Clean House”

Brooklyn Free Speech Radio

Play Episode Listen Later Dec 5, 2017 52:03


Sports Social with Ed Easton Jr featured a full recap of the New York Giants drama surrounding Eli Manning’s benching as well as the firings of Ben McAdoo and Jerry Reese with KIRS correspondent Stan Talouis.Twitter - @FunnyManStan I spoke with Brooklyn Nets forward Trevor Booker during his annual “Booker’s Breakfast Assist” event. All the cereal accumulated during this event went back to Bed-Stuy Campaign Against Hunger.Twitter - @35_FitzCheck out Keepingitrealsports.com & SportsSocialPod.com for more information

PERML Productions
SSC Episode 18: Goodbye Spicy!

PERML Productions

Play Episode Listen Later Jul 22, 2017 78:03


Kirs and Nino discuss the latest in DC, and revisit our trip to beautiful Asheville, NC!!!! Tune in and chime in.

Sports Social with Ed Easton Jr
Sports Social: Episode 32 "Muhammad Ali Tribute"

Sports Social with Ed Easton Jr

Play Episode Listen Later Jun 7, 2016 94:17


6/7/16 Sports Social with Ed Easton featured a full show tribute to the late Muhammad Ali better known as "The World's Greatest". KIRS correspondent Stan Talouis calls in to give his thoughts on the great champion's career and civil right's presence. Sports Social airs live Monday - Thursdays from 1pm - 3pm(est) on Soundcast FM (Tune In Radio App) Check out Keepingitrealsports.com & SportsSocialPod.com

Sports Social with Ed Easton Jr
Sports Social: Episode 29 "Nick Hunt"

Sports Social with Ed Easton Jr

Play Episode Listen Later May 17, 2016 114:29


5/17/16 Sports Social with Ed Easton featured an discussion on game one of the NBA Western Conference Finals. KIRS boxing correspondent Danny Clase calls in to talk possible Mayweather vs McGregor match up? Professional volleyball player Nick Hunt joined me in studio to discuss his career and plans. Sports Social airs live Monday - Thursdays from 1pm - 3pm(est) on Soundcast FM (Tune In Radio App) Check out Keepingitrealsports.com & SportsSocialPod.com

Multiple Sclerosis Discovery: The Podcast of the MS Discovery Forum
Multiple Sclerosis Discovery -- Episode 34 with Dr. Jill Hollenbach

Multiple Sclerosis Discovery: The Podcast of the MS Discovery Forum

Play Episode Listen Later Mar 10, 2015 14:09


 [intro music]   Hello, and welcome to Episode Thirty-Four of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m your host, Dan Keller.   This week’s podcast features a follow-up interview from last week’s episode with Dr. Pierre-Antoine Gourraud. This week, we interview Dr. Jill Hollenbach about killer immunoglobulin-like receptors – or KIR – and their relationship with human leukocyte antigen and MS. But to begin, here’s a brief summary of some of the latest developments on the MS Discovery Forum at msdiscovery.org.   Take some time to check out our most recent data visualization on our website. Under the research resources tab, you can find a series of interactive data visualizations useful for MS researchers. Our most recent one organizes 142 ongoing clinical trials into an interactive bubble chart. We have another visualization on the natural history of MS symptoms. The interactive bar chart allows you to see the change of various symptom severity in MS over a 30-year period.   If you enjoy this podcast and find MSDF helpful, please consider supporting us with a donation. MSDF is run by a small team of full-time employees and a few regular contributors. We are devoted to bridging the gaps between scientific disciplines to speed the flow of information from the lab bench to the bedside. Our ultimate goal is to facilitate the discovery of a cure. We believe one of the best ways to do that is to bring independent, research-focused news to a professional audience on a platform that fosters discussion and discourse. Help keep us going by visiting our website and clicking on the green “Support MSDF” button next to the “Research Resources” tab on the top right of our screen.   [transition music]   Now to the interview. Dr. Jill Hollenbach is an assistant professor in the department of neurology at the University of California, San Francisco. She met with science journalist Cynthia McKelvey, to talk about KIR in MS.   Interviewer – Cynthia McKelvey Why don’t we start by introducing what KIR is, how it’s different from the potassium channel and what its relationship is to HLA.   Interviewee – Jill Hollenbach Well, KIR is an acronym, it stands for killer immunoglobulin-like receptor. These are receptors on the surface on the surface of natural killer cells. They use generally, not in every case, but use HLA as their ligand and they have either an activating or inhibitory effect on natural killer cells.   MSDF You mentioned in your talk earlier today at UCSF that they are difficult to study. Why is that?   Dr. Hollenbach Just in terms of their genetic architecture. KIR occupy a complex on chromosome 19, it’s a multigene complex. And so on any individual haplotype that’s one chromosome, an individual can have between 4 and 14 KIR genes. These genes are really recently evolved, and so they’ve kind of arisen in humans as a result of repeated events of recombination and gene duplication. So what that means is that one KIR gene often at the nucleotide level looks an awful lot like another KIR gene. And so we’ve had a lot of issues. A lot of the methodologies that are available right now in terms of sequencing, part of this has to do with a lack of human genome reference alignments, but there has been a lot of difficulty in examining these genes because they look so much like one another.   MSDF How does that relate to why they haven’t really seen them on genome-wide association studies?   Dr. Hollenbach There’s a couple of reasons why we don’t see them on genome-wide association studies. One is that, as I mentioned, there haven’t been a lot of good reference alignments, so as a result we don’t actually see a lot of SNP markers on most of the common platforms that are used for genome-wide association studies. And then the markers that are there are often lost to quality control, because we have a lot of gene content variation, which is kind of like a copy number variant. And so if we only see a result for one chromosome, for example, for a given SNP, that is not going to pass general quality control thresholds. And, of course, you have to recognize that when you’re doing these GWAS studies, you’re looking at a hundred thousand, five hundred thousand, a million markers, two and a half million markers, so you’re not going one-by-one and saying, well this KIR-1, we expect to only see one copy or that sort of thing. So it just gets thrown out in the mix with things that don’t pass QC.   MSDF How does KIR relate to multiple sclerosis specifically?   Dr. Hollenbach Well, we’re trying to figure that out. So there’s been a small number of studies examining KIR in multiple sclerosis, and what seems clear is that variation in the KIR does play a role in susceptibility to multiple sclerosis. It may play a role in progression; we’re just not sure. There’s not been enough work done to say definitely what’s going on, but there’s enough evidence to say that something is going on. And some of the work that I talked about in my talk today, an analysis of KIR variation along with HLA in an African-American MS cohort, a very large study population, it seems clear that there is some association of KIR variation with susceptibility or protection for multiple sclerosis.   MSDF Why study the African-American cohort? What does that tell us about MS in general?   Dr. Hollenbach We want to study them because they’re different from one another; so an African-American population is going to look very different genetically with respect to KIR and HLA from a European-American population. So we want to know two things. We want to know is there something different going on with these genes with respect to disease in these different populations, OR at the same time we want to know is something the same going on? And so we can learn something both from these commonalities and differences, and both can be really important in genetics. So if there’s something that is important that’s specific in the African-American population, we want to know that, and we can only find out by looking at a number of different ethnic groups.   MSDF Let’s talk a little bit more about interaction between KIR and the HLA ligand, and how that plays in with Bw4. And if we can define all of those things, too, that would be great.   Dr. Hollenbach Okay. Well, so KIR molecules, as I mentioned before, need to see something, they need to have a ligand on their target cell. We have both inhibitory receptors and activating receptors. The job of the NK cell is to perform immune surveillance. So NK cells kind of wander around the body, and what they’re looking for are cells that don’t look healthy. So what does that look like and what is an unhealthy cell? It’s a cell that is virally infected, it’s a tumor cell. Those are the two main things that NK cells are looking for. And it’s a really important function because they’re part of what we refer to as the innate immune system; it’s the first line of defense against these kind of unhealthy events.   And so what does an unhealthy cell look like? Well, one of the things that happens in both viral infection and tumors is downregulation of MHC class I. That’s what the KIR are looking for. So when an NK cell encounters a healthy cell, it will see HLA class I, it immediately recognizes this is self, this is healthy cell at least in terms of what I’m able to see as an NK cell, and it will move on and it won’t cause any damage to the cell after making contact between the KIR and that ligand.   On the other hand, if the KIR doesn’t see this HLA ligand, the inhibitory KIR, an activating KIR – and we’re still not completely sure what the activating KIR ligands are – but the activating KIR is also bound to something on the surface of this cell. If the activating KIR is bound but the inhibitory KIR is not, what happens is the NK cell is going to lyse that cell which is presumably unhealthy in some ways – tumor or viral infected.   Now HLA class I – actually all HLA molecules – have another primary really important role which is antigen presentation to T cells. Class I molecules present antigen to the CD8-positive T cells, and so that’s how these T cells perform their role in terms of the active immune response. KIRs see a different part of the HLA molecule than the T cell receptors, and so they see kind of this piece of the HLA class I molecule that’s kind of on the side of where the T cell receptors sit. And the variation that they see on that HLA class I molecule can kind of be defined by these broad categories based on the particular amino acid residues. And it’s generally just from two to four amino acid residues that determine whether or not a given KIR can see a given HLA class I molecule.   So one of these epitopes, as we call them – and if they were originally defined on a serological basis because specific antibodies could recognize them – so one of these epitopes is referred to as Bw4; these are epitopes that we mainly see on HLA-B molecules – not all – so depending on the population, human population, may be from 40 to 60 or 70% of HLA-B molecules will have this Bw4 epitope. Some HLA-A molecules also bear the Bw4 epitope. So that’s what some KIR molecules, specifically KIR3DL1, is seeing is Bw4.   The results of the study that I talked about today and what we saw is in this African-American multiple sclerosis cohort, individuals that have both 3DL1 and HLA alleles with the Bw4 epitope appear to be protected from multiple sclerosis. And so we see higher frequencies of this combination in our control population relative to patients. So that suggests a protective effect of that combination, 3DL1 plus Bw4.   MSDF Where do you see the research going from here?   Dr. Hollenbach Right now the data that we’re looking at is strictly in terms of carrying frequencies for these particular genes. So these genes are actually highly variable at the allele level, so any given gene like KIR3DL1 has many, many variants that are already known, and likely many variants that we haven’t identified yet because the technology has not been there. The technology is just about now caught up to the point where we are able to examine at the sequence level the variation within these specific KIR genes, and so I think that that’s really the next step. And we’re actually taking steps to start examining this cohort and others in terms of this fine-grained variation in the KIR genes.   MSDF Very good. Thanks.   [transition music]   Thank you for listening to Episode Thirty-Four of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations.   Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances.   We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org.    [outro music]

DECOMPRESSED
DECOMPRESSED 020: ANKA, DOYLE AND MCKELVIE ON COSTUME DESIGN

DECOMPRESSED

Play Episode Listen Later Aug 30, 2013 60:52


Decompressed is a sporadic podcast about comics craft. This time I’m talking to Kris Anka, Ming Doyle and Jamie McKelvie to talk about the art of character design. It’s a visual medium, so this stuff is absolutely paramount. Ming’s designs are central to her wonderful MARA with Brian Wood, Kirs’ designs are all over X-Force and McKelvie has (damn him) has sent more cosplayers rushing to their sewing machines than any artist working today. We cover the whole topic, in terms of how they specifically approach the choice, their favourite designs, the question of plausibility, specific costume designers, Emma Frost’s clothes pyre, my inability to say “Segue”, the horrific idea of how I’d redesign Batman and on and on and on. Join us! It’s not rubbish. You can find the show-notes here.