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Meta's global reach and heavy AI investments give it an undeniable edge over other digital marketing platforms. In today's episode, we are exploring how Meta's ongoing innovations will reshape advertising in 2026 and what this means for your business or agency. Lauren shares her firsthand experience testifying at a House subcommittee about how Meta's AI tools are helping small businesses scale. We unpack why Meta's capabilities (like Andromeda) are game-changers for businesses that overcome AI fears and leverage Meta's creative diversification.Plus, we look at real-world examples of how AI is amplifying business growth, and how Meta's ecosystem can supercharge marketing strategies in ways other platforms simply can't match. Join the conversation now if you want to stay ahead of the curve in 2026.In This Episode:- Lauren's AI testimony at a House subcommittee- Fear of AI replacing jobs vs. AI as a growth opportunity- The rising need for human interactions - Meta's global influence on internet users- Why Meta is the best ad platform - Meta's investment in AI and its implications for 2026- Statistics on Meta's usage and revenue growthMentioned in the Episode:Global Internet Users: https://www.statista.com/statistics/273018/number-of-internet-users-worldwide/ Facebook Usage Statistics: https://www.demandsage.com/facebook-statistics/ Previous Episodes on Meta's Andromeda: https://perpetualtraffic.com/?s=andromeda Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram -
Do you feel like your Facebook ads are suddenly wasting money, but you can't pinpoint why? Are you looking for a way to adapt your strategy to Meta's latest AI-driven algorithm changes without guessing what works? To discover how to navigate the new Andromeda algorithm and use a specific creative strategy to lower your costs, I interview Tara Zirker.Guest: Tara Zirker | Show Notes: socialmediaexaminer.com/697Review our show on Apple Podcasts.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
ALLLLLL ABOARD!!! TOOT TOOT! It's time for EPIC MONOLOGUES, Luke CAMPAIGNING, Percabeth PERCABETHING, Prophecies PROPHECIZING, and we have Janani K. Jha to help us out, plus interview clips with Walker Scobell, Dior Goodjohn, and Craig Silverstein. This is my favorite episode of this podcast ever. Premiere Watch Party (available for all on Youtube): https://www.youtube.com/live/5XtcZWpSiWQ?si=3diK1KQH-s99j96vJoin our Patreon for live watch parties, special episodes, episode outlines, access to our exclusive Discord server, and more!! patreon.com/seaweedbrainBuy us a coffee: https://ko-fi.com/seaweedbrainpodcastFollow our show:Instagram @SeaweedBrainPodcastTwitter @SeaweedBrainPodTikTok @EricaSeaweedBrainThreads @SeaweedBrainPodcast More https://linktr.ee/SeaweedbrainpodCheck out our merch shop! https://www.teepublic.com/stores/seaweed-brain-podcast?ref_id=21682
We are in for another treat with this episode! We discuss Episode 3 of Season 2 of the Percy Jackson and the Olympians Disney+ show, "We Board the Princess Andromeda." This episode is about Clarisse, and also about Luke's MLM. WHO is the head of Kronos's marketing team? Also, what is Allison Sims's backstory? This show has successfully converted us into Clarisse supporters. They won't get us yet on Luke, though. Links:SUPPORT US ON PATREON: https://www.patreon.com/camphalfpod?fan_landing=trueSUPPORT US ON KO-FI: https://ko-fi.com/camphalfpodSEND US AN AUDIO MESSAGE: https://www.speakpipe.com/CamphalfpodJOIN OUR DISCORD: https://discord.gg/gzHYsUbdgrMERCH: https://www.zazzle.com/store/camphalfpod
Running Meta ads can get confusing fast, especially when you hear people say you should combine all your targeting together. After managing ads for years, I've never seen that work well for course creators. Get the 48-Hour Ad Fix Audit Today, I break down why separating warm and cold audiences still matters (even with the Andromeda update) and how Meta's algorithm actually treats each group behind the scenes. If you've been unsure about your targeting setup or why your cold leads suddenly got expensive, I share exactly what you can do to get better results without overthinking it. Watch this episode on YouTube! Please click here to give an honest Rating/Review for the show on iTunes! Thanks for your support! Kwadwo [QUĀY.jo] Sampany-Kessie's Links:Get 1:1 Meta Ads Coaching from Kwadwo!Say hi to Kwadwo on InstagramSubscribe to The Art of Online Business's YouTube Channel
In this episode of Business Not As Usual, Megan sits down with Kwadwo (pronounced QUĀY-jo), host of the Art of Online Business podcast, to break down one of the most misunderstood growth decisions in online business: when your business should start using Meta ads, and when it actually makes sense to hire an ads manager versus running ads yourself. This conversation is refreshingly honest and grounded. Rather than selling ads as a magic solution, Kwadwo explains why ads don't fix broken offers, why more eyeballs on the wrong funnel usually lead to frustration (not revenue), and how organic sales are the clearest signal that paid traffic will work. If you've ever felt tempted to "just throw money at ads" because you're tired or stuck, this episode will help you slow down and make a smarter decision. Kwadwo also walks through what he calls his Olympic Gold Medal Testing Framework: a practical way to lower Facebook and Instagram ad lead costs by treating ads like ongoing experiments, not all-or-nothing bets. He shares how to test conservatively, adapt to changes like Meta's Andromeda update, and protect your nervous system (and your cash) while still scaling sustainably. You'll also hear a nuanced discussion about money, pressure, and leadership, including why saving cash creates more freedom than most online business conversations admit, how knowing your profit per lead changes everything, and why no ethical ads manager should ever guarantee results. Whether you've never run ads, have had a bad experience in the past, or are right on the edge of scaling again, this episode will help you make decisions from clarity instead of urgency. Special Moments from the Episode "Jesus saves. Meta ads do not." — why ads amplify what's already working (or broken) The clearest sign your business is ready for Meta ads (and why income alone isn't enough) Kwadwo's profit-per-lead math for deciding DIY ads vs hiring an ads manager Why lead magnet ads + launch ads beat "brand-building ads" early on How to think about the Meta Andromeda update without panic or overreacting A candid conversation about saving money, runway, and freedom most online spaces avoid Kwadwo's Links: →48 Hour Ad-Fix Audit (get $20 off!): https://quayjo.thrivecart.com/audit/?coupon=MEGADS →Listen to The Art of Online Business: https://theartofonlinebusiness.com/aoob-podcast/ Connect with Meg →Discover how to craft a powerful business origin story that sets you apart, builds trust, and inspires clients to work with you: https://meganyelaney.com/business-story-blueprint →Come say hi on Instagram: https://www.instagram.com/meganyelaney
Andromeda je emisija koja više od dvadeset godina, utorkom, u našem radijskom prostoru educira javnost i podiže svijest o Svemiru i našem mjestu u njemu. Uz stručnog suradnika odgovara se na pitanja slušatelja, komentira vijesti iz astronomije, astrofizike i astronautike. Emitira se od 20:00 - 22:00
The JournalFeed podcast for the week of Dec 8-12, 2025.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Monday's Spoon Feed:Personalized hemodynamic resuscitation targeting capillary refill time (PHR-CRT) over a 6 hour intervention period demonstrated less need for organ support in patients with septic shock at 28 days.Wednesday's Spoon Feed:The EVERDAC trial found delayed invasive blood-pressure monitoring is noninferior to early arterial catheterization in patients with shock in terms of 28-day mortality.
This Minisode was originally uploaded with Episode 310: Weird LA w/ Abby Denton - some of the topics discussed might be outdated. Subscribe to our Patreon to listen and watch the Minisodes as they release every week! http://patreon.com/CHILLUMINATIPOD Mike Martin - http://www.youtube.com/@themoleculemindset Jesse Cox - http://www.youtube.com/jessecox Alex Faciane - https://www.youtube.com/@StarWarsOldCanonBookClub/ Editor: DeanCutty Producer: Hilde @ https://bsky.app/profile/heksen.bsky.social Show Art: Studio Melectro @ http://www.instagram.com/studio_melectro Logo Design: Shawn JPB @ https://twitter.com/JetpackBraggin
Meta's new Andromeda retrieval engine demands REAL creative diversity. Get Tier 11's Creative Diversification Package and access Media Buying + Data Suite for FREE:https://tiereleven.com/cd Is Meta forcing all your ad spend into one product, regardless of what you actually want to scale? What if the very thing limiting your business isn't your ads or your offer but the algorithm you've been unintentionally training?In this ad lab session, John Moran breaks down how we rebuilt a campaign architecture using a Meta version of the “feeder strategy” and unlocked the ability to steer Andromeda rather than be steamrolled by it. We share how we took a business stuck with 80% of its conversions tied to a single SKU and created a system that grows multiple products profitably, on demand.If you've ever wrestled with product concentration, SKU imbalance, or runaway algorithm bias, this episode is your roadmap out. We cover the data, the levers, the mistakes, and the surprising benefits we didn't see coming. In This Episode:- Applying Google's feeder strategy to Andromeda- Case study: Training Meta to sell more products- CTR and CPC change after restructure- All clicks versus link clicks- The story-first creative advantage- Real results from testing the feeder strategy- Risk, scaling, and product diversification- How the strategy impacts company valuation- Final insights and episode wrap-upMentioned in the Episode:Previous Episode on Google's Feeder Strategy: https://www.youtube.com/watch?v=xndq5dyX5sU Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with John Moran:LinkedIn: https://www.linkedin.com/in/johnmorangads Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 -
Subscribe to DTC Newsletter - https://dtcnews.link/signupMeta's latest update wasn't just noise. Pilothouse strategist Taylor Cain breaks down how Andromeda's smarter delivery system let them consolidate campaigns, increase CTRs, and scale cleaner than ever this BFCM.For CMOs optimizing Meta spend across brands or business units...30% YoY CTR lift through creative-persona alignment + fewer campaignsWhy campaign consolidation is outperforming classic testing structuresPartnership ads: how Pilothouse uses Meta's dynamic features to drive both reach + retargetingHow to rethink frequency, offer alignment, and creative iterations mid-campaignWhat MTA tools like Triple Whale unlocked when real-time tracking mattered mostWho this is for: CMOs, paid media directors, and growth leads navigating platform complexityWhat to steal:Test in your best campaign, not in isolation (if the creative is ready)Meme-style statics backed by real offers = full-funnel magicLet performance inform your campaign segmentation — not the other way aroundTimestamps:00:00 Meta's Shift Away From Traditional Testing01:08 What Actually Drove BFCM Winners02:56 Andromeda's Real Impact on Performance04:22 Why CTR Jumped During BFCM05:47 Consolidation Is Beating Fragmentation07:37 How Creative Is Fed Into Winning Campaigns11:00 Why Partnership Ads Took Off This Year23:52 The Email + Paid Connection That Mattered MostHashtags:#ecommerce #dtc #digitalmarketing #paidmedia #metads #andromeda #adcreative #performancemarketing #bfcmmarketing #q4marketing #retentionmarketing #emailmarketing #attribution #triplewhale #marketingstrategy #growthmarketing #ugcads #creatorads #partnershipads Subscribe to DTC Newsletter - https://dtcnews.link/signupAdvertise on DTC - https://dtcnews.link/advertiseWork with Pilothouse - https://www.pilothouse.co/?utm_source=AKNF567Follow us on Instagram & Twitter - @dtcnewsletter
"Do you care enough about new customer acquisition? What you care about shows up based off of your actions, not your thoughts or your words."Meta's Andromeda update broke everyone's brain and most brands still haven't recovered. Nehal Kazim, CEO of Ad Pros, argues that the industry overcorrected by wildly overproducing content, burning through budgets on concepts that never receive meaningful spend. His math: you're paying $250-500 per asset for creatives that never get tested. Kazim has spent 13 years running campaigns for brands like Canada Goose and DTC companies doing $10-16 million a month. His solution is a profitability-first framework that tracks new customer contribution margin daily and calibrates creative output to what your budget can actually support. Also discussed: why Meta told him to stop hook testing, and the $25K Cardi B ad he hated that completely crushed.SPONSORSSwym - Wishlists, Back in Stock alerts, & moregetswym.com/kurtCleverific - Smart order editing for Shopifycleverific.comZipify - Build high-converting sales funnelszipify.com/KURTLINKSAd Pros: https://adpros.comNehal on Instagram: instagram.com/nehalkazimNehal on LinkedIn: linkedin.com/in/nehalkazimWORK WITH KURTApply for Shopify Helpethercycle.com/applySee Our Resultsethercycle.com/workFree Newsletterkurtelster.comThe Unofficial Shopify Podcast is hosted by Kurt Elster and explores the stories behind successful Shopify stores. Get actionable insights, practical strategies, and proven tactics from entrepreneurs who've built thriving ecommerce businesses.
Composer Ken Allen shaped the soundscape of an entire Sierra era, from Space Quest to Kings Quest, and that unmistakable Sierra logo fanfare burned into every retro-gamer's brain. Now he's back with a full new soundtrack for SpaceVenture, and we go deep into how it all came together. In this episode, Ken walks through the craft behind his new score, the evolution from MT-32 to modern orchestral libraries, the stories behind iconic Sierra tracks, the surprising inspirations for SpaceVenture's music, and what it's like to reunite with the Two Guys from Andromeda after decades. Expect anecdotes, technical insight, nostalgia, and plenty of behind-the-scenes lore from one of the genre's defining composers. Mangia! Some corrections. - Beats Per Minute (not beats per second - that wouldbe crazy). - Composer for Silent Running was Peter Schickle, not Jerry Goldsmith. - Kazoo Orchestra is on the 2001 Theme and synth was used Blue Danube. Check out the SpaceVenture Soundtrack! The Phantom Fellows is out now! GOG Steam itch.io Fireflower Mac App Store The Phantom Fellows Pin/Magnet by CanvasQuest! The Phantom Fellows Players Companion (Guide to Must-See Moments!) Grab a Phantom Fellows shirt or mug at AdventureGameMerch.com ! Shek out our friends in the Adventure Game Hotspot Network: Space Quest Historian's 6 Adventure Game Puzzles That Can Go F Themselves (feat. Paul) Adventure Game Geek's Geek Plays Demos - Theropods, "An Adventure Lost In Time" OneShortEye's Why (almost) No One Solves This Game Adventure Game Hotspot's Point and Click Adventure Game Stories You'll Relate To (feat. Anna & Paul) Conversations with Curtis' Paul Korman & Daniel play The Phantom Fellows! & Daniel plays Return to Monkey Island with Anna & Paul from the Classic Gamers Guild Podcast Tech Talk with Daniel Albu's Mark Seibert: The Sound of Sierra On-Line
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VIDEO: https://youtu.be/fy-4pUGrGRE This month we're talking about our favorite Sci-Fi TV of all time! From The X-Files, the Pluribus, to The Prisoner, to Lost, to Andromeda, to Stargate Universe, to Battlestar Galactica, to Sliders! Join the conversation and our Discord for just three dollars at http://www.patreon.com/ReactionShots(Sorry my mic got a little hot here and there.)
Subscribe to DTC Newsletter - https://dtcnews.link/signupWhen Sarah Carusona showed up to a DTC event last year, she didn't know it would spark her first client. That client's still with her. Today she runs BA Commerce, where her team drops into brands and drives growth from the inside.For DTC founders scaling from $5M to $20M who need strategy and execution in one package.What you'll learn:Why fractional CMOs often fall short and what brands really need insteadHow to drop in a trained operator who owns growth from top to bottomThe key metrics Sarah watches before touching a budget: contribution margin, AMER, LTV, and the “organic ratio”Why most influencer budgets are broken and what happens when you tie pay to performanceHow to focus your team's time when there's no room for fluffWho this is for:Founders and growth leads who are tired of hiring gaps, agency fluff, and shiny-object distractionsWhat to steal:Rebuild your org chart around execution, not job titlesStructure your influencer deals like paid media, not PRGet obsessed with contribution margin and work backward from thereTimestamps00:00 Why micro-iterations waste ad spend02:00 Sarah's global move and early consulting leap04:00 Building BA Commerce and the growth operator model09:00 How Sarah evaluates brands and sets growth metrics12:00 Creative fatigue, Andromeda, and persona-driven ads15:00 Creator partnerships and a tiered influencer program17:00 Why organic content still drives the biggest wins19:00 Modern Meta account structure and testing philosophy21:00 The biggest mistakes high-growth brands make23:00 Why product quality drives everything in growth25:00 Attribution, incrementality, and Sarah's forecasting model27:00 How Sarah uses AI and where she draws the lineHashtags#dtcpodcast #ecommerce #dtcbrands #mediabuying #growthmarketing #metaads #ugcads #influencermarketing #digitalstrategy #founderstories #shopifybrands #emailmarketing #smsmarketing #marketingpodcast #directtoconsumer Subscribe to DTC Newsletter - https://dtcnews.link/signupAdvertise on DTC - https://dtcnews.link/advertiseWork with Pilothouse - https://dtcnews.link/pilothouseFollow us on Instagram & Twitter - @dtcnewsletterWatch this interview on YouTube - https://dtcnews.link/video
Mehr Umsatz mit Verkaufspsychologie - Online und Offline überzeugen
In dieser Folge spreche ich offen über die Herausforderungen, die das neue Andromeda Update von Meta für Facebook- und Instagram-Ads mit sich bringt. Viele berichten von steigenden Leadpreisen und sinkender Performance – doch woran liegt das wirklich? Ich zeige dir, warum klassische Werbebotschaften jetzt ins Leere laufen und wie psychologische Variation und kreative Ansprache zum entscheidenden Erfolgsfaktor werden. Du erfährst, wie du mit gezielten Strategien Werbemüdigkeit überwindest und deine Zielgruppe wieder begeisterst. Lass uns gemeinsam herausfinden, wie du auch in Zeiten von Algorithmus-Updates mit Verkaufspsychologie an der Spitze bleibst. Lass uns sprechen: https://matthiasniggehoff.de/
JCO Editorial Fellow Peter Li and author Dr. Jahanzaib Khwaja discuss the ASH 2025 Simultaneous Publication article, "A New Validated Staging System for AL Amyloidosis With Stage lllC Defining Ultra-Poor Risk: AL International Staging System." TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Peter Li: Welcome to this episode of JCO Article Insights. I am Dr. Peter Li, JCO's Editorial Fellow, and today, I am joined by Dr. Jahanzaib Khwaja on a new validated staging system on AL amyloidosis with stage lllC defining ultra-poor risk, AL International Staging System. This is a simultaneous publication that will be presented at this year's ASH Conference. At the time of this recording, our guest has disclosures that will be linked in the transcript. So, Dr. Khwaja, let's start off first: What would you say is the significance of your study? Dr. Jahanzaib Khwaja: Thank you very much. This is an important study in that, in the current treatment era, we have really improved outcomes of patients with systemic AL amyloidosis. Traditionally, the staging systems that have been employed, which are the Mayo 2012 and the European modification 2016, have been founded in eras where there were historic treatment protocols. So the significance of this new staging system is looking at outcomes of patients in the modern treatment era. That is patients who are treated with daratumumab-based treatments in the first line. And this is kind of the largest study which is externally validating a new prognostic model in the current treatment era with modern outcomes. Dr. Peter Li: Can you tell our listeners what is different about your new staging system? Dr. Jahanzaib Khwaja: The traditional staging systems, the Mayo 2012 and the European modification of 2016, looked at outcomes of patients with systemic AL amyloidosis with historic treatment protocols. And we know that they looked at outcomes according to an NT-proBNP and troponin, and in the Mayo 2012, they looked at it with the addition of the dFLC, which is the difference in the involved and uninvolved free light chain. Over the years, we have seen that outcomes have improved, and over decades, actually, outcomes are much better when we compare them to the previous decade. If we look at current treatment approaches, those traditional staging systems inadequately determine the poorest prognostic risk. So they are unable to tell us those who are going to perform poorly. Our current new validated staging system looks at the traditional NT-proBNP and troponin but uses the addition of the longitudinal strain. This is an echocardiographic parameter, and it is used widely in treatment centers who treat amyloidosis. This really identifies those ultra-high risk patients, and these are the patients who will perform poorly in current treatment protocols. And why is that important? Well, we need a robust staging system in the current treatment era which can stratify patients who will do well but also stratify those patients who do not do well. Because that is important for counseling patients, for risk stratification, for treatment approaches, and in the future, for designing clinical trials. Dr. Peter Li: And that is referring to the longitudinal strain greater than -9% and NT-proBNP greater than 8,500 and then the high-sensitivity troponins greater than 50, which will define the new staging system. Can you talk more about how you picked these cutoffs and also what that alludes to in terms of the outcomes that you have discovered in this age of daratumumab-based therapy? Dr. Jahanzaib Khwaja: Yeah, that is a really excellent question because we have aimed to build upon traditional staging systems. So clinicians have used these traditional models for many, many years, and they have robustly underpinned our stratification of patients and how we counsel patients. So we didn't want to change some of these well-established thresholds, but we wanted to test them in the current treatment era. So the NT-proBNP of 8,500 and the high-sensitivity troponin of 50 were the traditionally used thresholds. And they actually stand the test of time. But we found that longitudinal strain additionally and independently predicts outcome independent of these other biomarkers. It is independent actually as a continuous variable, so you can cut this at a number of different stratification points and find independence. But we wanted to determine and discriminate those with the poorest outcomes. So we validated a longitudinal strain threshold of greater than -9% by deriving this from a dataset of patients with the traditionally highest risk. Those are with European stage lllB. And looked at the optimal threshold with time-dependent ROC analysis. So we did this in our derivation cohort and then validated this externally in our external validation cohort amongst a number of centers in Europe, in the US, and in the UK. And it is important to note because longitudinal strain is an echocardiographic parameter, and traditionally the limitations are considered to be inter-vendor and inter-operator variability and intra-operator variability, and there are challenges with reproducibility of some of these measurements. So that is often cited as a limitation. But we found, when we have externally validated this across different centers using different platforms, actually the threshold of -9% is independently predictive of poorer outcomes independent of the traditional NT-proBNP and troponin thresholds, and it is robustly predictive of poorest outcomes. We know that those with stage lllC have a median overall survival of 4 to 7 months in the modern treatment era. And if we sub-stratify these by patients treated with daratumumab, outcomes have improved, but still, even if we look at daratumumab-treated patients, one-year overall survival is still only around 50 percent. So these are a poor risk group in the modern treatment era. Dr. Peter Li: Which kind of makes sense in a way because this kind of predicts whether they have amyloid-related cardiomyopathy. So I think this all tracks with our listeners. But given the poor outcomes even with daratumumab-based therapies, do you think this new staging system would change practice, if at all? Dr. Jahanzaib Khwaja: Yeah, I think that is a really good point because I think it comes to the question of why we use a staging system. What are its applications? I think one of the key things we think about in the clinic is how do we counsel patients when we first talk to them about their diagnosis. So there is a lot of information, but predominantly people want to know, what is my outlook going to look like? And as I say, in the bortezomib treatment era, 2010 to 2020, we used to say you have stage lllB, you have very poor outcomes, median survival maybe around six months. We have shown here that actually those with lllB have much better outcomes definitely over 12 months, up to 24 months in those with daratumumab-based therapies. So we need to counsel them in a different way. We then also need to say, "Well, who are the ultra-high risk?" So we said those with the longitudinal strain of greater than -9% with the traditional NT-proBNP and troponin cutoffs. And those patients will have poor outcomes. We need to talk about palliation. We need to talk about alternate treatment approaches. And then importantly for the community is about treatment and clinical trial design. So again, traditionally the traditional high-risk group lllB used to be considered an exclusion for all major trials. So these were excluded in the ANDROMEDA study, which led to the approval of daratumumab-based therapy, and multiple other trials. And we show here that actually patients with lllB should not be excluded from these studies because they do have good outcomes. And I think we make the important point that those with lllC, who do have poor outcomes, they need a different treatment approach, and we need to think about stratifying these patients differently. So perhaps the next modality of treatment will be the anti-fibril antibodies or a mode of treatment which can clear antibodies or clear the amyloid fibrils from the organs and reduce the organ toxicity early on. We know that those with lllC have poor outcomes particularly within the first year, and organ dysfunction really predominates here. So a different treatment approach is required, and we need to design trials specifically for these patients which look beyond anti-plasma cell clone therapy but also look at clearing the amyloid fibrils and improving organ function as this is predominantly the cause of death in these patients. Dr. Peter Li: That's an excellent point right there. Do you foresee any limitations to this new staging system, or can you comment on is there potentially a better way to refine this staging criteria in the future? Dr. Jahanzaib Khwaja: Yeah, I think that is a really excellent point to consider, that staging systems always need refining across treatment eras. So we have looked at the bortezomib era, and then we have validated this in the daratumumab-based era. We know that amongst different countries access to treatment varies. We know that there are a number of factors which determine your health-related outcomes. That's access to healthcare, speed of diagnosis, access to tertiary diagnostics, ability to biopsy, and then supportive care. And I think our staging system highlights the importance of organ dysfunction predominantly causing death early on. And I think that as treatments improve this should be refined. So the expectation I think is, as we have better anti-plasma cell directed therapies, and as we hopefully develop anti-fibril antibodies and anti-fibril clearance drugs, that we will need to revalidate new models to effectively prognosticate in this treatment era. And I also think that as we become a bit more sophisticated with our approaches, we know that this can be refined in the future looking at other prognostic factors with regards to healthcare outcomes. I would say one of the strengths, however, of this model is that it builds on the traditional model, and it's quite simple to use. You just have the NT-proBNP and the troponin, and then longitudinal strain, which is used quite frequently in amyloid centers, and an echocardiogram is used in essentially all patients for diagnosis. So I think it will certainly be quite practical. But certainly I think, as you say, as treatment approaches change over time, and as we have further options in the future, we will need to refine prognostication. Dr. Peter Li: For the listeners out there, let's say someone comes in our clinic and we diagnose them with stage lllC amyloidosis. Can you comment on what clinical trials are out there that potentially they can refer their patients to? You mentioned anti-fibril therapy, which I think would be the way of the future. Can you kind of comment what you know at this current stage and point listeners in the right direction? Dr. Jahanzaib Khwaja: This is the challenge in amyloidosis. We don't have specific trials that are looking at those with the highest risk. And at present, even the ISA International Guidelines talk about risk according to the old treatment approaches and discuss attenuating our current chemotherapy approaches. And I think that for clinicians out there who identify those at the highest risk, it is really important to have a multidisciplinary approach, to consider palliation and palliative services early, and really work with your fellow cardiologists and renal physicians and neurologists to enable the best supportive care you have in order to deliver this anti-plasma cell directed therapy. We know that actually you only need for most patients small amounts of doses of chemotherapy to get good clonal responses, and we have seen that even in the bortezomib era that actually they have good CR rates and more impressive CR rates with daratumumab. But because of the organ dysfunction, it can be really challenging to deliver these doses. And supportive care is going to be really important particularly for these challenging patients. The future will be designing clinical trials that are appropriate for these patients. At present, we currently don't have available options, but I think the more we gather this data, the more we work collaboratively as a community, we will be able to mobilize our resources and get the best outcomes for these patients. Dr. Peter Li: First build the field of dreams and then hopefully more therapies will arrive in the future. Thank you so much, Dr. Khwaja, for speaking about the JCO article, "A New Validated Staging System for AL Amyloidosis With Stage lllC Defining Ultra-Poor Risk: AL International Staging System," and for all your valuable input today. Dr. Jahanzaib Khwaja: Thank you very much. Dr. Peter Li: Make sure to check out the presentation at this year's ASH Conference taking place from December 6 to December 9. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Justin joins me for the last Journal Jam for the year - we cover a lot of ground from Andromeda to the pulmonary physiology of flying rhinoceroses.
What if 2026 could be the year you finally stop spinning your wheels and actually run your boutique like a CEO? In this episode, Ashley sits down with "Retail Professor" and denim twin, Sara Burks, to unpack their biggest retail predictions for 2026—from AI and Meta's new Andromeda algorithm to niching down, live selling, and building a content engine that actually works. Ashley and Sara share what they're seeing across thousands of boutiques, what's changing fast, and how the most successful store owners are planning now for a more profitable, peaceful year ahead. They'll also walk you through what to expect inside the Best Year Yet Challenge, happening January 6–8. You'll learn: Why AI is no longer optional—and how smart retailers are using it in every part of their business What Meta's new Andromeda algorithm means for your content, reach, and ad strategy How live selling and video can humanize your brand and deepen customer loyalty in 2026 How the Best Year Yet Challenge helps you map real strategy (not just wishful goals) for profit and peace all year long Why niching down is the only way to stand out, charge more, and build true brand authority Join the Best Year Yet Challenge - January 6–8 — three days of live Zoom sessions with Ashley, Sara, Jeff, and the Boutique Hub team Best Year Yet Join The Boutique Hub ____________________________ Ashley Alderson: Instagram The Boutique Hub: Website | Facebook | Instagram | Pinterest | TikTok | YouTube
Send us a Text Message (please include your email so we can respond!)Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840823If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
In this exciting episode, we sit down with Deep Astronomy and Space in a Nutshell, two of the biggest Nepali astronomy content creators, known for sharing mind-blowing space facts and cosmic news with millions across the world. From the fascinating journey of 3I Atlas, the science of comets, and the behavior of binary star systems, to deeper questions like whether alien life exists in the universe, this conversation explores some of the most intriguing mysteries in astronomy. We dive into the Milky Way & Andromeda collision, the cosmic background signals, auroras, volcanic eruptions on distant worlds, and how scientists study strange phenomena like land breathing on Earth. The creators also reveal how they started producing space content, how they build viral videos, approach brands, deal with scams, and target a global audience through educational storytelling. We also discuss the Starlink network, solar energy, returning to the Moon, and the growing Nepal scientific community. Whether you're curious about space, fascinated by the universe, or interested in content creation strategy, this episode brings together astronomy, creativity, and science communication at its finest. GET CONNECTED WITH: Deep Astronomy and Space in Nutshell The Deep Astronomy Instagram - https://www.instagram.com/thedeepastronomy/ Facebook - https://www.facebook.com/thedeepastronomy Space In Nutshell aka. Siddhant Acharya Instagram - https://www.instagram.com/spaceinnutshell/ Instagram - https://www.instagram.com/astrosid__/ Facebook - https://www.facebook.com/spaceinnutshell Facebook - https://www.facebook.com/siddhantacharya27 YouTube - https://www.youtube.com/channel/UCy-qVInxrICN6ynjoIHcv0A
Getting martial arts leads but they keep disappearing? You're not alone. Most martial arts school owners blame "tyre kicker" leads, but the real problem is your follow-ups. Here's the exact automation system that fixes it.IN THIS EPISODE:Why calling leads "tyre kickers" kills your martial arts business growthThe 60-second automation system that stops lead ghostingHow Amanda turned 11 martial arts leads into 7 premium signups ($83 cost per student)The martial arts marketing follow-up sequence that works across email, SMS, and voicemailWhy Facebook's Andromeda algorithm changes affect your martial arts school adsThe content strategy that creates higher-quality martial arts leadsTRANSCRIPTIONThe world of martial arts marketing, marketing your martial arts school.So let's say you're running ads at the moment; it could be through Facebook, through Google.They typically take a different pathway or a different strategy.So maybe we'll lean into Facebook for now.But regarding leads in general, let's say you are running a campaign and you've got lead enquiries coming in and they just ghost you.So you're all excited, you get a lead notification, see the phone number, and perhaps you pick up the phone and call them.No answer.You try to message them.No answer.So what's the deal?Are all these leads just notoriously bad?Is it just a distraction?Is it too hard to get hold of people?I'm recording this close to December right now.Are people just more distracted than ever, and it's hard to get hold of them?Or are they just all the leads, martial arts leads, just tyre kickers?There are a few things that we can consider here.And if you are in the scenario where you're getting leads and they are ghosting you, there are a few things that could be wrong.Number one, I think I want to address the mindset around leads.And a lot of times I hear school owners talk about how leads are tyre kickers, and it's not typically their fault.Because let's say you're running a campaign and you've got one lead notification, two, three, four, and you can't get hold of anybody.And four leads in, all of a sudden your entire mindset is shifted.You feel here's another time waster.
Sponsor Details:This episode of Space Nuts is brought to you with the support of NordVPN. To get our special Space Nuts listener discounts and four months free bonus, all with a 30-day money-back guarantee, simply visit www.nordvpn.com/spacenuts or use the coupon code SPACENUTS at checkout.Cosmic Queries: The Birth of Our Sun, Future Discoveries, and Gas GiantsIn this thought-provoking Q&A episode of Space Nuts, hosts Andrew Dunkley and Professor Fred Watson tackle an array of intriguing listener questions that span the cosmos. From the possibility of witnessing the birth of our sun to the future of astronomical discoveries, this episode is filled with insights that will leave you pondering the mysteries of the universe.Episode Highlights:- The Birth of Our Sun: Daryl from South Australia wonders if we could ever witness the birth of our sun through ancient light. Andrew and Fred explore the limitations of observing such distant events and the fascinating concept of light echoes that allow us to glimpse historical cosmic phenomena.- Future Discoveries in Astronomy: Rennie from California asks what we might uncover in the next century regarding dark matter, dark energy, and the Big Bang. The hosts discuss the rapid advancements in technology and how they may lead to groundbreaking discoveries in our understanding of the universe.- Gas Giants and Their Moons: Dave from New Jersey poses a hypothetical scenario about a super Jupiter with an Earth-sized moon. The discussion delves into tidal locking and the potential for life in the Goldilocks zone of such massive planets, revealing the complexities of planetary formation.- Gas Giants and Supernovae: Cal from Swansea questions whether a gas giant could absorb debris from a supernova to become a star. The hosts clarify the dynamics of supernova explosions and the potential for rogue planets to host their own moons, igniting curiosity about the possibilities of life in the cosmos.For more Space Nuts, including our continuously updating newsfeed and to listen to all our episodes, visit our website. Follow us on social media at SpaceNutsPod on Facebook, X, YouTube Music Music, Tumblr, Instagram, and TikTok. We love engaging with our community, so be sure to drop us a message or comment on your favorite platform.If you'd like to help support Space Nuts and join our growing family of insiders for commercial-free episodes and more, visit spacenutspodcast.com/about.Stay curious, keep looking up, and join us next time for more stellar insights and cosmic wonders. Until then, clear skies and happy stargazing.Become a supporter of this podcast: https://www.spreaker.com/podcast/space-nuts-astronomy-insights-cosmic-discoveries--2631155/support.
Subscribe to DTC Newsletter - https://dtcnews.link/signupIn this episode, Nik Sharma (founder of Sharma Brands) returns to the pod to dig into how DTC brands should be thinking right now: simple, tested offers for Black Friday/Cyber Week, and how to turn those one‑time buyers into repeat customers.For DTC operators scaling from ~$50 M to $500 M:What makes a Black Friday offer work (hint: simple, tested, clear).Why retention after the sale is your leverage — and how to bake it into flows, creative and post‑purchase experience.The internal creative strategist role: why brands who won the recent platform updates had strong in‑house creative ideation, not just an agency doing the work.The “two‑layer strategy” to ads: first who, then why — and how that applies to landing pages, creatives and funnels.Why many brands still get tracking/events wrong on landing pages and why that kills scale.Who this is for: Founders, growth leads and performance marketers in DTC brands who are heading into Q4 and want to both hit a big seasonal number and build playbooks for 2025.What to steal:A plain‑text thank‑you email from the founder that goes out post‑purchase (low cost, high emotional return).Structure your Black Friday/Cyber Week offer now: test ahead, keep it simple, and communicate what's included vs not.Build the “creative strategist” role internally: someone whose job is crafting hooks, angles and formats for your brand (not just delegating to the agency).Timestamps00:00 Retention mindset after Black Friday02:00 Building simple and effective BFCM offers04:00 Why most Black Friday customers don't return06:00 Creative strategy and the Andromeda update08:00 Why brands need an internal creative strategist10:00 Going deeper on avatars and buyer psychology12:00 Marpipe and the importance of better DPAs14:00 Rethinking top-of-funnel in 202516:00 Cutting through the noise with creators and TikTok18:00 Pharmacy trends, GLP-1s, peptides, and affiliates20:00 Supplements, problem-solution marketing, and AI prompts22:00 How Nik uses AI for reporting and creative inputs24:00 Sharma Brands acquisition and team evolution26:00 Sleep optimization and Q4 habits28:00 Landing page fundamentals and data accuracyHashtags#dtcpodcast #niksharma #sharmabrands #ecommercegrowth #bfcm2025 #blackfridaystrategy #d2cpodcast #directtoconsumer #marketingstrategy #facebookads #retentionmarketing #creativestrategy #andromeda #paidmedia #landingpages #marpipe #tiktokmarketing Subscribe to DTC Newsletter - https://dtcnews.link/signupAdvertise on DTC - https://dtcnews.link/advertiseWork with Pilothouse - https://dtcnews.link/pilothouseFollow us on Instagram & Twitter - @dtcnewsletterWatch this interview on YouTube - https://dtcnews.link/video
Join David, Michael, and Jesse as they return to podcasting! Over the break we each played our own different long game.Games discussed: Sweet Lands, Andromeda's Edge, Twilight Imperium 4th ed.Join our Discord Server at THIS LINKFollow us on Instagram with THIS LINK
With the latest GEM and Andromeda updates, creative diversification is the only way to crack Meta's algorithm. We're offering you 30 monthly deliverables,10 ad types, media buying, and access to Tier 11's data suite to help you stay ahead.Get our exclusive Creative Diversification Package at: https://www.tiereleven.com/cd The days of throwing up a simple product photo to your Meta ads and hoping for conversions are long gone. If you're not diversifying your creative strategy, your results will suffer. We continue our discussion with Andrew Foxwell on the latest Meta GEM update and its implications for ads.Andrew shares why evolving your creative strategy is the only way to thrive in this new era of advertising on Meta. We'll also guide you on how to rethink your creative process and share tactics that are driving incredible results for our clients.In This Episode:- The importance of creative diversification - What makes a successful creative strategy today- How to implement creative diversification- Real-world results from creative diversification- How to hire creative strategists- Get in touch with Andrew FoxwellMentioned In The Episode:Previous Episodes on Andromeda: https://perpetualtraffic.com/?s=andromeda Foxwell Digital courses and GPT at https://www.foxwelldigital.com/ Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Andrew Foxwell:Website: Foxwellfounders.com Email: andrew@foxwelldigital.comConnect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram -
El Marketing que Murió: Las 4 CLAVES de la Mentoría (Más de 3 horas de Estrategia Real)En este resumen intensivo de la mentoría grupal de la comunidad Emprende con Juan Manuel, analizamos las estrategias de marketing que realmente funcionan ahora, centradas en la inteligencia humana y la conexión. Juan Manuel es un experto con casos de éxito en varios países, que ha gestionado más de 2 millones de euros en publicidad para e-commerce y dirige desde España. Descubre cómo dejar de luchar batallas que ya están perdidas de antemano y enfocarte en la rentabilidad.1.
Creative diversification is now the primary lever that Meta is rewarding. You need at least 30+ fresh concepts per month to unlock the algorithm's full potential. Our Creative Diversification Package will give you that and more. Check out the offer at: https://www.tiereleven.com/cd Meta's latest update will fundamentally change how your ads are ranked, served, and scaled. However, most advertisers don't even know it's already live. This week, I'm joined by Andrew Foxwell, one of the sharpest Meta strategists in the game.Andrew breaks down Meta's new GEM model, the “central brain” now powering ad delivery across Facebook, Instagram, and WhatsApp. We talk about cross-platform signals, why organic content matters again, and how GEM connects directly to Andromeda's creative ranking system. We look at workflows and what your team should change immediately to stay ahead of this shift.In This Episode:- How GEM impacts Meta ads performance- The difference between GEM and other Meta updates- How advertisers can train GEM effectively- GEM's impact on the role of organic content- What makes a “good ad” now- The necessary mindset shift for advertisersListen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Andrew Foxwell:LinkedIn: https://www.linkedin.com/in/andrew-foxwell-2a533b7 Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram - https://www.instagram.com/laurenepetrullo/LinkedIn - https://www.linkedin.com/in/laurenpetrullo Consult Mongoose Media - https://mongoosemedia.us/ Mentioned in this episode:
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The Meta Andromeda update has shaken up ad performance for a lot of online course creators but it doesn't have to ruin your results. Get the 48-Hour Ad Fix Audit I walk through a simple ad setup that works with Andromeda instead of against it, including how to adjust your ad sets, creative, and targeting so Meta's algorithm actually helps you. I also share why panicking (or over-tweaking) your ads makes things worse and how to keep testing the right way. Grab a tea or coffee and let's make your ads work again in 2026. Watch this episode on YouTube! Please click here to give an honest Rating/Review for the show on iTunes! Thanks for your support! Kwadwo [QUĀY.jo] Sampany-Kessie's Links:Get 1:1 Meta Ads Coaching from Kwadwo!Say hi to Kwadwo on InstagramSubscribe to The Art of Online Business's YouTube Channel
In this episode, Nick Boddington uncovers the biggest mistake small advertisers make on Meta: budgeting. Learn why your ads aren't under-performing because of your copy or creative, but because your budget isn't giving Meta enough data to learn. Nick breaks down how the Andromeda structure helps smaller advertisers simplify campaigns, consolidate spend, and let Meta's AI optimise faster. Discover how to test smarter, structure your Facebook ads for consistent results, and scale profitably, even on a limited budget.BUT THERE'S MORE...Follow me on Instagram to keep up to date with all the latest hacks: @nickboddington You can now watch the episode on Youtube!
Meta ads have changed dramatically after the Andromeda update — higher CPAs, unstable performance, and the same strategies no longer work. In this video, Jordan West breaks down the new 3-step Andromeda Reset framework that top advertisers are using to stabilize results, improve MER, and scale profitably in 2025.You'll learn:Why ad quality and engagement quality now matter more than everHow to set a simple MER guardrail to stop overspendingThe truth about Advantage+, when to use it, and when NOT toHow to structure campaigns with 8–15 real creative concepts (not trims)Why Conversions API (CAPI) + value passback + deduping is non-negotiableHow to troubleshoot attribution lossWhat “wider adoption” means for your Meta strategyHow to protect your ad account from volatilityThe new rules for scaling post-AndromedaIf your Meta ads feel unpredictable or expensive, this is your reset.===============================
Ethereal Encounters Welcomes David Sereda LIVE, Friday, November 21st, 2025 - 3 PM EST Topic: 3I/Atlas and the Hyperdimensional: A New Solar System Bio: David Sereda is an inventor, author, filmmaker, and spiritual researcher known for his work in quantum harmonics, frequency-based healing technologies, UFOs, and consciousness development. Born on August 21, 1961, in Edmonton, Alberta, Canada, he grew up as the second eldest in a family of five boys. His father, Dr. Lynn Sereda, a Ph.D. in educational psychology from UC Berkeley, profoundly influenced him by introducing meditation at age 13 to pursue "God Consciousness" and spiritual growth. The family briefly relocated to Berkeley, California, in 1964 for his father's studies, amid a period of social and spiritual change that shaped David's early interests. His childhood included significant challenges, such as his parents' divorce, which deepened his quest for spiritual enlightenment. Over 23 years, David worked as a tree planter in British Columbia, personally planting more than 1.3 million trees while integrating physical labor with daily meditation practices. He has over 40 years of experience in meditation, studying world religions (including Buddhism, Hinduism, Gnostic Christianity), yoga, breathwork, sound healing, philosophy, physics, UFOs, crop circles, sacred sites, and consciousness. David's career spans multiple fields: he has authored books like Mona Lisa's Little Secret, Face to Face with Jesus Christ, and The Great Pyramid and The Harmony of the Order (co-authored with his wife, Crystal Sereda); directed and produced documentaries such as Dan Aykroyd Unplugged on UFOs (2005), Quantum Communication (2009), and From Here to Andromeda (2017); and appeared on numerous radio and TV shows. In 1994, he reported a profound spiritual encounter, describing a face-to-face meeting with Jesus Christ, which led him to become a disciple while honoring his diverse past teachers. With Crystal, whom he met in Los Angeles through Dan Aykroyd during a UFO footage analysis session at the House of Blues, David co-developed the Quantum ReGenesis meditation and consciousness course series (audio/video). They founded Lightstream Harmonics Technologies, focusing on natural technologies to imprint frequencies and vibrations into jewelry, crystals, and gem-powered EMF Rife frequency devices for healing and DNA activation. Their work explores Tesla technologies, scalar energy, and quantum science for spiritual and physical wellness. David continues to innovate in bio-electric healing systems and harmonic frequencies, offering courses and products through davidsereda.co. Regarding your reference to www.davidsereda.co, that site primarily showcases his inventions and products under Lightstream Harmonics Technologies (e.g., gem-powered healing devices), with limited biographical details—it positions him as the creator of these authentic, handcrafted items and provides contact info (email: DavidSereda@hotmail.com; phone: 250-551-7176)
Creative diversity is a must to crack Meta's new Andromeda algorithm and dominate your market. We're offering you 30 monthly deliverables,10 ad types, media buying, and access to Tier 11's data suite to help you stay ahead.Get our exclusive Creative Diversification Package at: https://www.tiereleven.com/cd Are you really getting the most out of your ad spend? What if you could drastically reduce your ad budget while seeing better returns? Well, in today's episode, I'm walking through a real SaaS case study where we helped a company grow from $1,300 to $393,000 in monthly revenue.I break down the exact steps we took to transform this business. From the ground up, we overhauled their ad strategy, implemented creative diversification, and scaled back ad spend to improve their media efficiency ratio (MER). I'll show you how we used both Meta and Google Ads to create an efficient, low-cost acquisition funnel, driving massive results without constantly increasing spend. If you're ready to stop just throwing money at ads and start getting real results with less, this is a must-watch. In This Episode:- Case study: scaling from $1,300 to $393K/month- Executing the nCAC reducer framework- Implementing the creative strategy framework- Results from Meta, Google, and Data SuiteMentioned in the Episode:Previous episodes on Andromeda: https://perpetualtraffic.com/?s=andromeda Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram - https://www.instagram.com/laurenepetrullo/LinkedIn - https://www.linkedin.com/in/laurenpetrullo Consult Mongoose Media -
Happy almost Thanksgiving! We've got some really fun things to nerd out on today. Cameras and video, Murderbot, Andromeda, Librarians: The Next Chapter, new music to check out. It's Sci Fi November!! After all, this is THE show for the multipassionate. We get to nerd out on all of the best things life has to offer!PLEASE SUPPORT TRBS in 2025!!!!Patreon: https://patreon.com/realbrianshowBuy Me a Coffee: https://www.buymeacoffee.com/iamtherealbrianMusic Spotify Playlists: TRBS 2025 Playlist on SpotifyTRB's GLORIOUSNESS (New Music) Playlist on SpotifyThe Captain Influence Playlist on SpotifySubscribe to The Real Brian Show Apple: https://podcasts.apple.com/us/podcast/the-real-brian-show/id1160475222Spotify: https://open.spotify.com/show/3UsRunmoQzHkrWbwmAjmLM?si=e76f534378ec4b8fYouTube: https://youtube.com/therealbrianSupport The Real Brian Show Buy Me a Coffee: https://www.buymeacoffee.com/iamtherealbrianPatreon: https://patreon.com/realbrianshowAMAZON LINK: Any time you purchase something off of Amazon, please consider using the TRBS affiliate link: https://amzn.to/3OVl49oAffiliate links mean I earn a commission from qualifying purchases. This helps support the channel at no additional cost to you!Connect With TRB and The Show! Website: https://realbrianshow.comFacebook: https://www.facebook.com/iamtherealbrian/TRBS Facebook Group: https://www.facebook.com/groups/realbrianshow/Twitter/X: https://twitter.com/iamtherealbrian
On this episode of The Board Boys Podcast we till into Tend from IV Studio! Rob also talks about a couple of new banger expansions as well as some hyped up Predator movies. We also talk about the current season of The Floor and Cam drops a joke that totall bombs. We also look back at Andromeda's Edge in this episodes Bump or Dump and there was a lot of feedback on this one! Until next time, we hope you like Board Games! 0:00 - Intro 9:06 - The Hobbit: There and Back Again 15:50 - Storyfold: WildWoods 20:40 - Critter Kitchen 27:10 - Rob Tangents Off 33:50 - Lost Ruins of Arnak - Twisted Paths Expansion 35:50 - Clank Catacombs - Underworld Expansion 41:22 - Tend Overview 46:05 - Interlude 46:35 - Tend Review 1:12:00 - Tend Final Thoughts 1:16:30 - Bump or Dump - Andromeda's Edge 1:23-50 - Outro and Patron Thanks
John Moran joins us this week as we unpack how the Andromeda model is reshaping media buying, why creative diversification is no longer optional, and how three rapid rounds of creative iterations dropped CPA from $44 to $25 in just 10 days. We walk you through the exact playbook we used to achieve these results. If you've ever paused an ad because it “spent too much,” or you're still clinging to last-click thinking, John's proven strategy will change how you build campaigns. We break down what's working right now and why creative is the new lever that drives everything else in Meta ads. In This Episode:- Introduction: Meta's creative diversification strategy- Case study: Fixing tracking with first-click & CAPI- Ad performance after creative iterations- How Meta optimizes ad delivery & CPA- Why understanding Meta's attribution model is critical- Results, reflections, and conclusionListen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with John Moran:LinkedIn: https://www.linkedin.com/in/johnmorangads Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram - https://www.instagram.com/laurenepetrullo/LinkedIn - https://www.linkedin.com/in/laurenpetrullo Consult Mongoose Media - https://mongoosemedia.us/ Mentioned in this episode:https://www.activecampaign.com/https://www.activecampaign.com/www.AdRoll.com/PThttps://discover.taboola.com/perpetual
Are Facebook and Instagram acting up and sending your ad results into a tailspin? It's time to get to the bottom of it... In this episode of Creative Juice, Jack and Circa break down major updates to Meta's advertising platform that every musician needs to know! Learn about the new Meta Andromeda system that's changing how ads are served on Facebook and Instagram, the effects of AI-generated content, and what these shifts mean for your music marketing strategies moving forward! If you want your Facebook and Instagram ads to reach the right audiences and drive new listeners, fans, and sales, this episode is a must-listen to stay ahead of the curve! DISCOVER: How Meta's Andromeda System Is Changing Ad Delivery Why Your Ad Targeting Strategies Need A Refresh What Creative Diversification Means For Your Campaigns Why Broad Targeting On Meta's Platform Is Optimal What Role AI Features Play In Your Ad Strategy How To Set Up Audience Segments For Better Insights RESOURCES: Learn The Top Music Marketing Strategies Inside IndiePRO Join Us In The Indepreneur Discord Server! Looking to expand your team or need marketing help? Apply to work with IndieX!
Hubble's new 2.5 billion pixel image reveals Andromeda in unprecedented detail.In this video, we explore our closest neighbouring galaxy, Andromeda. Created from 10 years of observations by the Hubble Telescope, the latest mosaic image unveils 200 million stars in glorious resolution. We're zooming into the details and picking apart the clues with a fine-tooth comb. From star formation to galactic collisions, what does the new image reveal about Andromeda's violent past… and its terrifying future?▀▀▀▀▀▀Get NordVPN 2Y plan + 4 months extra ➼ https://nordvpn.com/astrum. It's risk-free with Nord's 30-day money-back guarantee!▀▀▀▀▀▀Astrum's newsletter has launched! Want to know what's happening in space? Sign up here: https://astrumspace.kit.comA huge thanks to our Patreons who help make these videos possible. Sign-up here: https://bit.ly/4aiJZNF
In this episode, we dive into how AI is accelerating the shift in user-generated content for advertising. Donatas Smailys, Co-founder and CEO of Billo, shares why social algorithms now demand high-volume content, his view on using AI as a scaling tool for real human creators (not for generating fake humans), and the crucial role of authenticity and variety in winning on platforms like Meta and TikTok. He also discusses the future of trust and AI characters in the content landscape.Topics discussed in this episode: Why social algorithms now demand high-volume content daily. What makes a successful brand-creator relationship: emotion and performance data. Why Meta's Andromeda algorithm now wins with variety and volume of creatives. Why fake faces and AI-generated UGC are viewed as short-term gains with risk of backlash. How Billo uses AI to instantly generate the next creative from existing real human content. Why the future will require clear differentiation between real and AI content. Links & Resources Website: https://billo.app LinkedIn: https://www.linkedin.com/in/smailys/ Get access to more free resources by visiting the show notes at https://tinyurl.com/y2zubc9w______________________________________________________ LOVE THE SHOW? HERE ARE THE NEXT STEPS! Follow the podcast to get every bonus episode. Tap follow now and don't miss out! Rate & Review: Help others discover the show by rating the show on Apple Podcasts at https://tinyurl.com/ecb-apple-podcasts Join our Free Newsletter: https://newsletter.ecommercecoffeebreak.com/ Support The Show On Patreon: https://www.patreon.com/EcommerceCoffeeBreak Partner with us: https://ecommercecoffeebreak.com/partner-with-us/
Can an ultra-compact dwarf galaxy have a supermassive black hole at its center? Are there galaxies with supermassive black holes that are offset from their galactic centers? To find out, Dr. Charles Liu and co-host Allen Liu welcome “the other” Dr. Matt Taylor, an Assistant Professor of Astronomy at the University of Calgary, who joins us from the control room of the largest astronomical telescope in Canada, at the Rothney Astrophysical Observatory (RAO) in Alberta, Canada. As always, though, we start off with the day's joyfully cool cosmic thing, which starts with the discovery of a supermassive black hole in the middle of an ultra-compact dwarf galaxy M60-UCD1 located in the Virgo galaxy cluster. That led to the discovery of more 4 UCDs in the Virgo Galaxy Cluster and 1 in the Fornax galaxy clusters, but then the limits of technology prevented the discovery of any additional UCDs. But now, by using the James Webb Space Telescope, Matt and his fellow researchers (including Dr. Vivienne Baldassare, our former guest for Black Holes and Space Junk with Vivienne Baldassare) have just published a paper about their discovery that in the smallest, lowest mass UCD yet found, they found a roughly 2,000,000 solar mass black hole. Basically, that's a tiny galaxy to hold a supermassive black hole, and Matt is sure there are many more of these waiting to be discovered. After that Matt tells us about his atypical journey to astronomy, including his first career – as a professional chef. When cooking stopped being fun, Matt enrolled at a local community college and “moved from gastronomy to astronomy” as Allen puts it. Our first audience question comes from our Patreon Patron Taylor L, who asks, “Is it possible dark energy and the acceleration of the universe's expansion could be explained by the idea that the black hole we live in is constantly devouring matter from outside?” Matt passes on determining whether or not we live inside a black hole. But, he explains that while at the galactic level expansion is happening on a really large scale, at a smaller scale like our local group of galaxies (Milky Way, Andromeda, and local dwarf galaxies), our mutual gravitation counteracts that expansion. Matt goes on to discuss how accretion disks are what makes it possible to “see” a black hole, but that ultra-compact dwarf galaxies don't have gas and dust forming accretion disks. Instead, they use stellar velocities to find black holes in UCDs. Next up, Matt tells us about some of the research he's doing into archetypal compact elliptical (cE) galaxies, which have the mass of a giant galaxy put into the volume of a dwarf galaxy, and how black holes appear in these systems. And Matt dangles another upcoming paper about galaxies with supermassive black holes that are offset from their galactic centers. For our next audience question, Pshemo asks: “We often say gravity is weak compared to other forces. But in the right regimes, like near black holes and neutron stars, or on large cosmic scales, it dominates every other interaction. Should we stop calling gravity a weak force?” It's a thought-provoking question with an even better answer, so please watch or listen to the episode to hear it yourself from Matt. If you'd like to know more about Matt, you can check out his website, mataylor5128.github.io. (The 5128 comes from the famous and very cool galaxy NGC 5128, aka Centauras A) We hope you enjoy this episode of The LIUniverse, and, if you do, please support us on Patreon. Credits for Images Used in this Episode: Virgo and Fornax galaxy clusters. – Credit: Creative Commons / Atlas of the Universe/ Richard Powell Southern portion of the Virgo Cluster as imaged by the Vera C. Rubin Observatory in very high resolution, taken on June 5, 2025. – Credit: RubinObs/NOIRLab/SLAC/NSF/DOE/AURA Ultra-compact galaxy M60-UCD1. – Credit: NASA, ESA, CXC, and J. Strader (Michigan State University) Diagram of a black hole accretion disk. – Credit: NASA's Goddard Space Flight Center/Jeremy Schnittman Hubble image of Messier 32, an archetypal compact elliptical (cE) galaxy. – Credit: NASA/ESA Centaurus A (NGC 5128) – Credit: ESO/WFI (Optical); MPIfR/ESO/APEX/A.Weiss et al. (Submillimetre); NASA/CXC/CfA/R.Kraft et al. (X-ray) #LIUniverse #CharlesLiu #AllenLiu #SciencePodcast #AstronomyPodcast #MattTaylor #UltraCompactDwarfGalaxy #UDC #SupermassiveBlackHole #BlackHole #AccretionDisk #M60UCD1 #ArchetypalCompactEllipticalGalaxy #UltraCompactGalaxy
Meta's Andromeda update has disrupted digital marketing for good. But, we've cracked the code! We're offering you 30 monthly deliverables,10 ad types, media buying, and access to Tier 11's data suite to help you stay ahead.Get our exclusive Creative Diversification Package at: https://www.tiereleven.com/cd AI is not a buzzword. It is not a passing trend. It's the future of marketing. In this episode, we explore why big tech companies are pouring billions into artificial intelligence and how it's already transforming the way we run ads, create content, and optimize our campaigns. We break down some mind-blowing stats, including Google's projected $93 billion investment in AI this year and Meta's massive $81 billion spend. We discuss the changes we've already seen in our own campaigns, from the Meta Andromeda update to creative diversification, which is making ad optimization faster, more efficient, and far more productive. If you're not using AI to enhance your marketing efforts, now's the time to start, or risk falling behind. We challenge you to think about one task in your marketing that you really don't want to do anymore, and then find an AI tool to make that task faster, cheaper, and more efficient. In This Episode:- The massive AI investments from big tech companies- Amazon's investment and earnings from AWS- Applying AI innovation to marketing- Simple steps to start using AI todayMentioned in the Episode:Previous episodes on Andromeda: https://perpetualtraffic.com/?s=andromeda Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram - https://www.instagram.com/laurenepetrullo/LinkedIn -
While other advertisers scramble to figure out Meta's Andromeda update, we've cracked the code! Our Creative Diversification Package will increase your ads' reach by 50%+ and save you over $330k on agency fees.Join the winning 0.01% businesses now at: https://www.tiereleven.com/cd Do you feel overwhelmed by the speed of AI advancements? The tech world is evolving at an unprecedented rate, making it challenging to keep up, especially with giants like Meta and Google leading the charge. AI is the future of digital marketing, and if you're not adapting, you're falling behind.In this episode, we discuss the massive shift happening in marketing, fueled by AI. We break down how Silicon Valley's biggest players are investing billions into AI and how that's impacting everything from content creation to data analysis. With new AI tools emerging every day, we talk about the importance of creative diversification and how it can boost your ad performance, all while giving you a competitive edge in the market. Tune in now and let's make sure you're ready for the AI-powered future of marketing.In This Episode:- Why AI's bubble is now and how to keep up- How AI is powering marketing innovation- Big tech and governments' heavy investments in AI - Presentation of big tech's AI investments- Wrap up and key takeawaysMentioned in the Episode:Previous episodes on Andromeda: https://perpetualtraffic.com/?s=andromeda The Acquired Podcast: https://www.acquired.fm/ Investors' Business Daily Analysis on AI: https://www.investors.com/news/technology/ai-stocks-microsoft-apple-google-amazon-meta-capital-spending/ The Evolution of AlexNet: Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 -
While other advertisers scramble to figure out Meta's Andromeda update, we've cracked the code! Our Creative Diversification Package will increase your ads' reach by 50%+ and save you over $330k on agency fees.Join the winning 0.01% businesses now at: https://www.tiereleven.com/cd Do you feel overwhelmed by the speed of AI advancements? The tech world is evolving at an unprecedented rate, making it challenging to keep up, especially with giants like Meta and Google leading the charge. AI is the future of digital marketing, and if you're not adapting, you're falling behind.In this episode, we discuss the massive shift happening in marketing, fueled by AI. We break down how Silicon Valley's biggest players are investing billions into AI and how that's impacting everything from content creation to data analysis. With new AI tools emerging every day, we talk about the importance of creative diversification and how it can boost your ad performance, all while giving you a competitive edge in the market. Tune in now and let's make sure you're ready for the AI-powered future of marketing.In This Episode:- Why AI's bubble is now and how to keep up- How AI is powering marketing innovation- Big tech and governments' heavy investments in AI - Presentation of big tech's AI investments- Wrap up and key takeawaysMentioned in the Episode:Previous episodes on Andromeda: https://perpetualtraffic.com/?s=andromeda The Acquired Podcast: https://www.acquired.fm/ Investors' Business Daily Analysis on AI: https://www.investors.com/news/technology/ai-stocks-microsoft-apple-google-amazon-meta-capital-spending/ The Evolution of AlexNet: Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 -
Stop losing money on ads! Grab your copy of Tier 11's FREE calculator with all the actors and formulas you need to determine the most important metric in your marketing efforts.Download Your nCAC Calculator Now: https://www.tiereleven.com/ncac Joining us today is Cole Turner, Growth Strategist at Tier 11. We break down how incorrect nCAC (New Customer Acquisition Cost) calculations can make you believe you're profitable when you're actually hemorrhaging cash. Cole walks us through a real-world example of a beauty brand, showing how fixing their nCAC revealed a massive discrepancy that changed their entire business strategy. We also discuss how adjusting your ad spend to align with real business costs can actually help you scale. If you're spending on ads without understanding your real margins, you could be scaling in the wrong direction. Join the conversation now and get your business metrics in order before your next big marketing push.In This Episode:- What nCAC is and why it matters- Case study: nCAC error in a beauty brand's strategy- Common mistakes in nCAC calculations- How to calculate nCAC accurately- How overheads factor into nCAC on scale- Why ad spend efficiency isn't enough- The importance of knowing your numbersUnlock the Ultimate Marketing Advantage With Our Creative Diversification Package! Get 30 monthly deliverables,10 ad types, and access to the Tier 11 data suite. Available exclusively for 11 lucky businesses at: https://www.tiereleven.com/apply Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: https://www.youtube.com/@perpetual_traffic?sub_confirmation=1We Appreciate Your Support!Visit our website: https://perpetualtraffic.com/ Follow us on X: https://x.com/perpetualtraf Connect With Cole Turner:LinkedIn: https://www.linkedin.com/in/coleturner98 Connect with Ralph Burns: LinkedIn - https://www.linkedin.com/in/ralphburns Instagram - https://www.instagram.com/ralphhburns/ Hire Tier11 - https://www.tiereleven.com/apply-now Connect with Lauren Petrullo:Instagram -
Unlock the ultimate marketing advantage with Tier 11's Creative Diversification Package! Get 30 monthly deliverables,10 ad types, and access to the Tier 11 data suite. Available exclusively for 11 lucky businesses at: https://www.tiereleven.com/apply Are media buyers becoming obsolete? With Meta's Andromeda update and AI automating campaign optimization, most marketers are still stuck tweaking ads while missing the real levers that drive growth. If you're still relying on Ads Manager, you're already behind! In this episode, we break down why media buying alone won't cut it anymore. We discuss how AI is handling 80% of the heavy lifting and why your focus needs to shift to everything that happens after the click. From landing page congruency to email triage, customer reactivation, and how data flow impacts optimization, we share what agencies and brands must do to stay profitable. If you're managing campaigns or scaling a business, this one's for you!In This Episode:- Media buying and “after the click” opportunity- Funnels, offers, and landing page congruency - Redefining leads, opt-ins, and MQLs- Disqualifying bad leads and data hygiene - The role of growth strategist vs. media buyers- Why small marketing agencies are struggling- Shiny object syndrome vs. real business growth- Rethinking the customer journey to boost salesMentioned in the Episode: Andromeda Episodes: https://perpetualtraffic.com/?s=john+moran Episode 744: The Pros and Cons of Meta's New Advantage+ Creative Image Generator Tool: https://perpetualtraffic.com/podcast/episode-744-the-pros-and-cons-of-metas-new-advantage-creative-image-generator-tool/ Episode 743: Stop Pausing Winning Ads! Andromeda Ad Strategy That Changes Everything: https://perpetualtraffic.com/podcast/episode-743-stop-pausing-winning-ads-andromeda-ad-strategy-that-changes-everything/ Creative Diversification Playbook: https://perpetualtraffic.com/wp-content/uploads/2025/10/Creative-Diversification-Playbook-Practitioner-Guidance.pdf Marketing Performance Indicators Checklist: https://www.tiereleven.com/mpi Listen to This Episode on Your Favorite Podcast Channel:Follow and listen on Apple: https://podcasts.apple.com/us/podcast/perpetual-traffic/id1022441491 Follow and listen on Spotify:https://open.spotify.com/show/59lhtIWHw1XXsRmT5HBAuK Subscribe and watch on YouTube: