Podcasts about hdl cholesterol

Do you know your “remnant cholesterol”? It could be better than LDL for predicting your risk of having a heart attack or stroke; Vagal nerve stimulation for seizures—could adding a keto diet help? Exoskeletons that help runners, hikers, and cyclists have hit the consumer marketplace for recreational athletes; RFK Jr's HHS launches program to improve infant formulas; Insurers bilk taxpayers for billions by double-charging Medicaid.

Scientists who tracked almost 7,000 people, found higher levels of HDL raised the risk of an incurable eye disease. Dr. Bob Martin answers callers' health questions on a variety of topics

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on coronary artery calcium for risk stratification among persons with very high HDL cholesterol.

In this insightful discussion from the October 1, 2024 issue of JACC, researchers reveal that triglyceride-rich lipoprotein (TRL) remnants are significantly more atherogenic than LDL cholesterol, suggesting a need for updated risk assessment strategies. The study advocates for a shift towards evaluating lipoproteins on a per-particle basis, which could revolutionize the diagnosis and treatment of lipid disorders by focusing on the functional activity of these particles.

Titan Medical Center Owner and CEO John Tsikouris answers questions live from our social streams - Topic for today is: 8 ways to increase your Healthy HDL Cholesterol, which is the good kind of cholesterol. Our special this week is on both Semaglutide and Tirzepatide which is perfect for those who are trying to lose weight. Here's what you've been looking for! TitanMedical GLP Weight Loss Package SPECIAL! -GLP LEVEL 1 $150 OFF! -GLP LEVEL 2 $100 OFF! SEMAGLUTIDE WEIGHT LOSS THERAPY (FDA Approved Injectable "Ares" Therapy) This therapy can help reduce hunger to prevent overeating and regulate glucose levels to help your body process sugars more effectively. TIRZEPATIDE WEIGHT LOSS THERAPY (FDA Approved Injectable Therapy) This therapy is a once-weekly injectable peptide for weight loss therapy which mimics hormones that are involved in blood sugar control and appetite, that can help prevent you from overeating and curb your appetite. May also improve how well your body breaks down sugars and fat. It's the next step up from the Semaglutide therapy without the potential nausea side effect. Have a question? Join us live every Tuesday

Lowest Effective Tren Dose, Scott's clen protocol, Recovering Natural Test After a Decade? Primo & Cholesterol, Superdrol Opinions TIME STAMPS BELOW - DNS 231 Dave Crosland & Scott McNally

 With just one Teaspoon/day we give our bodies the nutrition that it needs.  The concentration of protein and vitamins in Spirulina has led many to classify it as the “most nutrient-dense food on the planet.” Compared to other foods gram for gram, it lives up to its reputation. The antioxidant that makes spirulina unique is called phycocyanin, which is a potent anti-inflammatory.  Spirulina can help every cell, tissue, and organ in the human body.  Spirulina helps:With diabetes to balance the blood sugar.To protect our cells through his anti-inflammatory phycocyanin.With powerful anti-oxidants.Very effective to heal sicknesses that are related to allergies and sinus. To reduce heavy metals and toxins in our body.Boost our immune system.To support body exercises. To reduce muscle tiredness and cramps.To heal and prevent heart diseases.To clean clogged arteries. To lower bad LDL cholesterol levels and raise the good HDL Cholesterol.To lower blood pressure.To keep your liver healthy.To heal your liver.To detox your bodyMy Video:  The Magic of Spirulina https://youtu.be/Y6nTjJgCZxEMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast2/The-Magic-of-Spirulina.mp3

In this episode, we're reviewing 11 essential longevity blood tests crucial for optimal executive performance and overall health. As busy individuals, we must prioritize our well-being, and these lab-based biomarkers provide valuable insights into our physiological state. These essential longevity blood tests are categorized into three fundamental areas: inflammation biomarkers, blood sugar/insulin resistance biomarkers, and heart health biomarkers. Each marker is vital in determining our health trajectory, from assessing systemic inflammation to understanding cardiovascular risk factors. Throughout the episode, you'll be provided not only an overview of each biomarker but also standard and ideal ranges for optimal health, the significance of these markers, and their implications for long-term health. Whether you're already proactive about your health or looking to enhance your wellness journey, this episode (and essential blood tests) equips you with the knowledge to make informed decisions about your longevity, performance, and health. — Impactful Quotes & Ideas — These biomarkers are slow-moving, often sitting dormant for some years, but they still set the stage for various chronic diseases and ailments, including advanced aging. Metabolic health, like aging, is not caused by one factor. Multiple variables play a role. Reducing stress and cortisol levels can go a long way toward reducing inflammation, insulin resistance, blood pressure, and so much more. — Connect with Julian and Executive Health — Curious about becoming a concierge client? Sign up for a complimentary Executive Health Meeting — ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.executivehealth.io/contact⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ LinkedIn — ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/in/julianhayesii/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Join the 'Executive Athlete Journal' + get our free executive health report: 'The Optimal Executive: 17 Impactful Actions to Look, Feel, and Stay at The Top of Your Game.' Visit— ⁠⁠⁠https://www.executivehealth.io/report⁠⁠⁠ ***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Any decision to begin the use of the following supplements or use any of the information on this website or podcast should be discussed with your doctor and/or medical practitioner. — Episode Timeline — (00:00) Introduction (04:17) 3 Big Categories + Big Health Picture (07:51) 1. HS—CRP (09:44) What is Insulin Resistance (12:06) 2. Glucose (13:19) 3. Fasting Insulin (14:07) 4. HbA1c (15:09) 5. HOMA2-IR (17:31) 6. Total cholesterol (18:58) 7. HDL Cholesterol (19:55) 8. LDL Cholesterol (21:11) 9. Triglycerides (22:27) 10. ApoB (23:29) 11. LP(a) (27:52) Recap Summary + Conclusion --- Send in a voice message: https://podcasters.spotify.com/pod/show/executive-health/message

ไลฟ์#72 : สรุปเล็คเชอร์ The Evolving Narrative of HDL-C หลังจากความล้มเหลวของงานวิจัยยา CSL112 ของบริษัท biotech CSL Behring ซึ่งเป็น Human Apolipoprotein A1 (apolipoprotein สำคัญบน HDL Particle) CSL112 ทำหน้าที่ผลักคอเลสเตอรอลออกจาก macrophage ของ plaque หลอดเลือด (Cholesterol Efflux Enhancer) และส่งเสริมเอ็นไซม์ LCAT ซึ่งหน้าที่สำคัญนี้ของ ApolipoproteinA1 บนผนัง HDL เป็นหน้าที่ที่นักวิจัยให้ความสนใจเป็นอย่างมาก และเป็นความหวังสำคัญในการสร้างกลยุทธ์เพื่อลดความเสี่ยง/รักษาโรคหลอดเลือดหัวใจอุดตันให้ดียิ่งขึ้น งานวิจัยสำคัญที่ล้มเหลวนี้ทำให้ความเข้าใจบทบาทของ HDL เหมือนกลับไปตั้งต้นใหม่ เพราะงานวิจัยสารพัดในอดีตที่ทดสอบการเพิ่มปริมาณคอเลสเตอรอลที่อยู่ใน HDL และทดสอบหน้าที่ของ HDL (functionality of HDL) ต่อการลดความเสี่ยงของโรคหลอดเลือดหัวใจดูเหมือนจะล้มเหลวไปหมด ไม่ว่าจะเป็น Niacin, Fibrate, Gemfibrozil, Hormone Replacement และ CETP inhibitors พี่ปุ๋มโชคดีที่ได้มีโอกาสฟังเล็กเชอร์เรื่อง The Evolving Narrative of HDL-C: Contemporary Insights on Quality vs Quantity for Targeting Cardio Protection เมื่อวันที่ 2 มิ.ย. 2566 จัดโดย National Lipid Association เป็นเล็คเชอร์ที่ดีมาก (กอไก่ล้านตัว) โดยศาสตราจารย์ผู้ทรงคุณวุฒิในด้านโรคหลอดเลือดหัวใจและ Lipidology 3 ท่าน หัวข้อเป็นดังนี้ค่ะ 1. Rethink the HDL Hypothesis: Then and Now โดย Professor Vera A. Bittner MD, MNLA University of Alabama 2. More than a Number: Functional Role of HDL for Atheroprotection โดย Professor Robert S. Rosenson MD, FNLA, Mount Sinai New York 3. Restoring confidence in HDL: Does CEC hold a promising as a potential therapeutic target? โดย Professor Christie M. Ballantyne MD, Baylor College of Medicine, Houston Texas (คนนี้เป็น Editor texbook สำคัญ Clinical Lipidology) แม้เนื้อหามันจะยาก แต่มันก็ท้าทายพี่ในการจะนำมาสรุปเป็นไลฟ์ #72 โพสต์นี้ไฮไลท์ประเด็นสำคัญจากเล็คเชอร์ HDL ที่พี่ได้ฟัง ให้อ่านเป็นน้ำจิ้มกันก่อน 1. HDL Nomenclature: HDL =/= HDL-C แต่เกี่ยวข้องกับขนาดของ particle ความหนาแน่น รูปร่าง ประจุ จำนวน ที่สำคัญมากคือ ประเภทของ Apolipoprotein (AI, AII, CIII, E) โปรตีน มากกว่า 300 ชนิด ไขมัน มากกว่า 300 ชนิด micro RNA ที่อยู่บน HDL Particle ส่งผลต่อหน้าที่ของ HDL ที่แตกต่างกันในคนแต่ละคน (wow!!) 2. ดังนั้น ความเชื่อฝังหัวที่มาจาก Classic Epidemiological Study อย่าง Framingham Study ว่า HDL เป็น good cholesterol การมีระดับ HDL-Cholesterol ที่สูง จะลดความเสี่ยงของโรคหลอดเลือดหัวใจนั้น เราควรจะลืมมันไปได้แล้ว 3. Low HDL-C predicts poor outcomes, high HDL-C is not protective for ASCVD (Atherosclerotic Cardiovascular Disease) 4. เราควรจะมุ่งความสนใจไปที่หน้าที่ของ proteins และ Lipid ที่อยู่บน HDL ซึ่งส่งผลให้ทำหน้าที่แตกต่างกัน ไม่ใช่สนใจปริมาณคอเลสเตอรอลที่อยู่ใน HDL พี่หวังว่าไลฟ์นี้ จะทำให้น้องๆที่มีความเชื่อว่า ไม่ต้องสนใจระดับ LDL-Cholesterol ที่สูง ตราบใดที่ระดับไตรกลีเซอไรด์ต่ำ และระดับ HDL-Cholesterol สูง เพราะ LDL particle จะมีขนาดใหญ่ ไม่เป็นอันตรายต่อหลอดเลือดหัวใจ และ HDL-C ที่สูงจะช่วยปกป้องหัวใจ จะได้เข้าใจเสียใหม่ว่า HDL-C ที่สูงไม่ได้มีฤทธิ์ในการปกป้องหัวใจแต่อย่างใด และ LDL particle size ก็ไม่ได้สำคัญมากไปกว่าจำนวน LDL particle #หาคำตอบสุขภาพจากงานวิจัยไม่ใช่จากเรื่องเล่า#FatOutHealthspans#ApoBgirl

This week, Dr. Kahn touches on mini-topics regarding HDL-cholesterol and the brain, pumpkin seeds and hair growth, lipoprotein(a), and others. He then shifts focus to the main topic: a 6-year update on the PESA trial in Madrid, followed by a look at the upcoming PrevCAD trial targeting young people. Just like at the Kahn Center, the PESA study in Madrid screened 'healthy' individuals aged 40-55 for silent atherosclerosis. It found that, at the 6-year mark, younger participants with high blood pressure and high LDL-cholesterol experienced rapid worsening of their condition. The PrevCAD trial in NYC will randomize young volunteers, aged 20-39 with silent atherosclerosis, to either receive aggressive therapy or undergo watchful waiting. Stay tuned for some insightful discoveries ahead.

กรดไขมันอิ่มตัวมีกลไกเพิ่มระดับ LDL-Cholesterol ได้อย่างไร European Society of Cardiology ได้ออกคำแนะนำในการป้องกันโรคหลอดเลือดหัวใจปี พ.ศ. 2564: 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice ในส่วนของโภชนาการ แนะนำให้บริโภคกรดไขมันอิ่มตัวไม่เกิน 10% ของพลังงานทั้งหมดที่บริโภคต่อวัน ในไลฟ์#66 นี้ พี่ปุ๋มได้งานวิจัยที่ดีมากมาจากคำแนะนำของ Dr. William Cromwell, Lipidologist ที่มีความเชี่ยวชาญเรื่อง Lipoproteins, ไขมัน มานานกว่า 30 ปี เพื่ออธิบายกลไกของกรดไขมันอิ่มตัวที่ส่งผลต่อการเพิ่มระดับ LDL-Cholesterol ซึ่งทำให้ ESC ออกคำแนะนำในปี พ.ศ. 2564 ดังกล่าว จำไว้ว่า Low Density Lipoproteins (LDL) เป็นต้นเหตุของโรคหลอดเลือดหัวใจอุดตัน งานวิจัยอ้างอิง 1. The effect of diet on cardiovascular disease and lipid and lipoprotein level https://www.ncbi.nlm.nih.gov/books/NBK570127/ 2. Mechanisms by which Dietary Fatty Acids Modulate Plasma Lipids https://www.sciencedirect.com/science/article/pii/S0022316622103810?via%3Dihub 3. Dietary Fatty Acids and the Regulation of Plasma Low Density Lipoprotein Cholesterol Concentrations https://www.sciencedirect.com/science/article/pii/S0022316623017492 4. Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.15.2.169?download=true 5. Does dietary cholesterol matter? https://zero.sci-hub.st/6086/6a5be4767ff78c355bec444f0ae5d8d2/grundy2016.pdf?download=true 6. Total fat intake for the prevention of unhealthy weight gain in adults and children: WHO guideline https://www.who.int/publications/i/item/9789240073654

Is cholesterol good or bad for you? How should you treat your serum cholesterol levels in the blood? Is LDL-C the best marker to look at when analyzing your cardiovascular health?  In this episode, Joe dives deep into the complex and controversial world of cholesterol, examining the ongoing debate around its impact on cardiovascular health. First, he breaks down the different viewpoints that dominate the topic of cholesterol, discussing the positives and negatives of each one. He also delves into various factors contributing to cardiovascular disease and how cholesterol fits into the bigger picture. Then, he explores 10 lesser-known benefits of lipoproteins and cholesterol, including cellular repair, hormone production, mood improvement, and more. Joe explains the different markers we should consider when assessing cardiovascular risk, such as non-HDL Cholesterol, ApoB, and LDL particle size. Finally, Joe shares his own experiences and offers his own approach on how to deal with cholesterol on a personalized level. Check out SelfDecode Join Joe's online community Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (01:09) - The cholesterol wars (02:55) - 10 Benefits of lipoproteins (10:46) - The tricky issues of cholesterol (18:11) - LDL, ApoB and Cardiovascular Disease (22:30) - The increase in evidence since 2015 (25:25) - Does lower cholesterol always mean better? (29:49) - Looking at the big picture

Prof.Thomas Dayspring M.D., FACP, FNLA เป็น Clinical lipidologist คนสำคัญที่มีความรู้และความเข้าใจคอเลสเตอรอลที่ร่างกายผลิตกับผลกระทบต่อสุขภาพหัวใจ เขาทั้งทำงานวิจัยและเขียน textbook เกี่ยวกับคอเลสเตอรอลมานานกว่า 30 ปี ที่พี่ปุ๋มประทับใจมากคือ เขาอายุ 77 ปีแล้วแต่ยังกระฉับกระเฉง เต็มไปด้วยพลังงาน เลคเชอร์ฟังเข้าใจง่าย สนุก ตื่นเต้น เห็นภาพ เขาเพิ่งเลคเชอร์เรียกได้ว่าเป็น Cholesterol Masterclass 4 ตอน เนื้อหาดีมาก ครอบคลุมความเข้าใจเรื่องการสร้างคอเลสเตอรอล ระบบการขนส่งไขมันภายในร่างกาย คอเลสเตอรอลกับการเป็นสาเหตุโรคหลอดเลือดหัวใจอุดตัน ยาลดระดับคอเลสเตอรอล การป้องกันภาวะคอเลสเตอรอลในเลือดสูง ซึ่งนำไปสู่ความมีอายุยืนยาวจากการลดความเสี่ยงโรคหลอดเลือดหัวใจ ซึ่งเป็นสาเหตุการเสียชีวิตอันดับต้นๆ จากรายงานขององค์การอนามัยโลก พี่ปุ๋มจึงจะนำ Cholesterol Masterclass ทั้ง 4 ตอนของเขาซึ่งเลคเชอร์ผ่าน Foolproof Mastery Channel มาสรุปให้น้องๆได้ฟังกัน 2 ตอนจบ ในตอนที่ 1 พี่สรุปไปเรียบร้อยในไลฟ์ #57 น้องๆกลับไปดูย้อนหลังกันได้ค่ะ หัวข้อคือ 1. คอเลสเตอรอลกับโรคหลอดเลือดหัวใจอุดตัน 2. การขนส่งไขมันในร่างกาย และ HDL-Cholesterol ในตอนจบ พี่จะสรุปต่ออีก 2 เรื่องคือ 3. ยาลดระดับคอเลสเตอรอล 4. การป้องกันโรคหลอดเลือดหัวใจอุดตัน เพื่อความมีอายุขัยที่ยืนยาว ฟังพี่สรุปจบแล้ว จะได้มีข้อมูลที่ถูกต้องจากงานวิจัยถึงอันตรายของการปล่อยให้ระดับคอเลสเตอรอลในเลือดสูงโดยไม่จัดการ และจะได้ไม่ไปหลงเชื่อ health influencer ในโซเชียลมีเดีย ที่ “เล่า” ว่า ระดับคอเลสเตอรอลที่สูงในกระแสเลือด มีความจำเป็นต่อร่างกาย ถ้าไตรกลีเซอไรด์ต่ำ HDL-Cholesterol แล้วละก็ ถึงแม้ LDL-Cholesterol สูง ก็ไม่เป็นอะไร เพราะ LDL-particle จะมีลักษณะ pluffy ซึ่งไม่เป็นอันตรายต่อหลอดเลือดหัวใจ เมื่อฟังเลคเชอร์ของ Prof.Thomas จบ พวกเราจะพบว่า…ไม่จริงเลยค่ะ

Prof.Thomas Dayspring M.D., FACP, FNLA เป็น Clinical lipidologist คนสำคัญที่มีความรู้และความเข้าใจคอเลสเตอรอลที่ร่างกายผลิตกับผลกระทบต่อสุขภาพหัวใจ เขาทั้งทำงานวิจัยและเขียน textbook เกี่ยวกับคอเลสเตอรอลมานานกว่า 30 ปี เขาเพิ่งเลคเชอร์เรียกได้ว่าเป็น Cholesterol Masterclass 4 ตอน ในช่องยูทูป Foolproof Mastery เนื้อหาดีมาก ครอบคลุมความเข้าใจเรื่องการสร้างคอเลสเตอรอล ระบบการขนส่งไขมันภายในร่างกาย คอเลสเตอรอลกับการเป็นสาเหตุโรคหลอดเลือดหัวใจอุดตัน ยาลดระดับคอเลสเตอรอล การป้องกันภาวะคอเลสเตอรอลในเลือดสูง ซึ่งนำไปสู่ความมีอายุยืนยาวจากการลดความเสี่ยงโรคหลอดเลือดหัวใจ ซึ่งเป็นสาเหตุการเสียชีวิตอันดับต้นๆ จากรายงานขององค์การอนามัยโลก พี่สรุปเนื้อหาตอนที่ 1 1. คอเลสเตอรอลกับโรคหลอดเลือดหัวใจอุดตัน 2. การขนส่งไขมันในร่างกาย และ HDL-Cholesterol เชิญรับฟังได้ค่ะ

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Liz: Good morning, I have a son who is one of the shortest in his class. He is 8 years old and has always been small for his age as well as a bit slow to hit a growth spurt. He takes a daily gummy vitamin and is active in jiu jitsu. He appears healthy and to be a good weight for his size but I'd like to know if there are any supplements that will help him maximize height growth. I'm sure some is due to genetics but Id like to focus on any nutritional needs I can if there is anything that comes to mind. Genetically, his paternal grandpa was under 5 feet tall. I was small like him as a child then grew in junior high to be tall for a woman and I have a tall dad. In addition, this son had 5 rounds of antibiotics in one year due to multiple ear infections which may also affect growth. However, even before the ear infections he was progressing slowly in height but not weight. Thank you for your time and I'm off to leave a 5 star review!   Katie: I just got my recently blood work back and my HDL was 109. My LDL, triglycerides we're all In range. I thought I heard you once say that high HDL is not good either. My LDL was 98 and triglycerides was 118. With the high HDL my “total cholesterol came in with a high value of 227. Should I try and lower my HDL?   Sarah: Hello! I'm reaching out for a veteran. I'm curious about heavy metal detox in someone who has shrapnel still inside their body. Is it a bad idea to do a heavy metal detox while shrapnel is still present? Is it better to just support liver detox pathways? What is the best way to go about dealing with ongoing immune responses from these metals like redness, irritation, food sensitivity, brain fog, etc? Will these metals eventually cause infertility? This will be a lifelong issue so I'm trying to figure out the best way to mitigate or lessen any more damage.   Lisa: Hi Dr Cabral My 15 yr old daughter vomits at the beginning of her period, our doctor says this is normal but it doesn't feel very normal to me. I'm not sure if any of this is relevant but she has allergies to dust & grass, has eczema, HAD asthma as a small child & is always tired, she is having her tonsils & adenoids out next week after 14 years of having issues with them & has never been able to breath out of her right nostril. TIA Lisa   Kerryann: Hi - Firstly i want to say i love, love, love your podcasts they are totally changing my life. I've just started to change my normal fasting routing (16/8) or (OMAD) to your 12/14 hour one and i'm loving it so much more. I'm in the UK - is it at all possible to get a copy of your book? the website does not give me an option to put my UK address in? I would also love to know more about becoming a IHP   Jeremar: I've recently discovered your podcast and been listening to it on regular now. My question is I'm interested in the Mediterranean diet but I'm unsure of foods and portion size and if there's a percentage of intake for each food group. I also work night shift which throws me off on eating times. Could you do a show these topics. Thanks for your help and for your shows. Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/2466 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

TODAY'S SPONSOR:SoWell, the at-home Fasting Insulin Test! Why Insulin? When you go to the doctor they test glucose and HbA1C, but not INSULIN! Over 50% of the population suffers from Insulin Resistance and it is at the root of diabetes, and many other chronic diseases.Even if you ask your doctor for a fasting insulin test, they often REFUSE! If you get it, your doctor might say that anything below 23 is "fine" but ideally, you may not feel well unless it's somewhere between 2-5.SoWell's at-home fasting insulin test also tests: fasting glucose, HbA1C, Thyroid Stimulating Hormone, Vitamin B12, HDL Cholesterol, LDL Cholesterol and Triglycerides!Use the code DANI10 to save 10% on this incredibly informative test!TODAY'S EPISODE:On today's episode, a very special guest comes on to interview me! I answered all the questions you submitted on Instagram so you can get to know me a little better. The questions are about my journey, my schooling, business and lots of very personal ones in there too!I hope you enjoy getting to know me better. We'll be back next week with another great interview!Thank you SO much for coming back week after week to listen to my podcast! It means so much to me!STAY IN TOUCH WITH ME:You can find me on Instagram @daniellehamiltonhealth & on Facebook at Danielle Hamilton Health.My website is daniellehamiltonhealth.com (scroll down to sign up for my Newsletter!)Thank you for subscribing, rating, reviewing, sharing and reposting the show! I appreciate each and every one of you! ⭐️⭐️⭐️⭐️⭐️ 

BLOOD SUGAR MASTERY is officially open for enrollment (through September 9th, 2022!) BSM is my signature group coaching course that will give you all the tools to master your blood sugar so you can gain energy, sleep better, burn fat, crush cravings and feel amazing! It will help give you the clarity on what to change and why so you can ditch the confusion and start making changes that really progress you forward WITHOUT trying to change everything all at once!

Today, I am blessed to have here with me Dr. David Harper. As a health educator and cancer researcher, Dr. David G. Harper has studied the impact of diet on human health for many years. The culmination of that extensive work is the BioDiet, a ketogenic food regimen that he and his wife began in 2012. The significant weight loss and health improvements they experienced led Dr. Harper to counsel hundreds of people on the BioDiet, with similarly consistent and impressive results. Dr. Harper is an associate professor of kinesiology at the University of the Fraser Valley and a visiting scientist at the BC Cancer Research Center, Terry Fox Laboratory. He holds a Ph.D. from the University of British Columbia and completed a post-doctoral fellowship in comparative physiology at the University of Cambridge. He is on the scientific advisory board of the Canadian Clinicians for Therapeutic Nutrition and is a member of the Institute for Personalized Therapeutic Nutrition. In this episode, Dr. Harper discusses fixing your diet before putting drugs in your body. The best cure for cancer is through prevention; Dr. Harper reveals how diet can be the key to avoiding chronic diseases and cancer. Dr. Harper dives deep into the connection between insulin resistance, obesity, and inflammation. Plus, he chats about how ketosis is a great way to lower inflammation and reverse insulin resistance. Tune in as Dr. Harper talks about studying the effects of a ketogenic diet on women with breast cancer. 

 With just one Teaspoon/day we give our bodies the nutrition that it needs.  The concentration of protein and vitamins in Spirulina has led many to classify it as the “most nutrient-dense food on the planet.” Compared to other foods gram for gram, it lives up to its reputation. The antioxidant that makes spirulina unique is called phycocyanin, which is a potent anti-inflammatory.  Spirulina can help every cell, tissue, and organ in the human body.  Spirulina helps:With diabetes to balance the blood sugar.To protect our cells through his anti-inflammatory phycocyanin.With powerful anti-oxidants.Very effective to heal sicknesses that are related to allergies and sinus. To reduce heavy metals and toxins in our body.Boost our immune system.To support body exercises. To reduce muscle tiredness and cramps.To heal and prevent heart diseases.To clean clogged arteries. To lower bad LDL cholesterol levels and raise the good HDL Cholesterol.To lower blood pressure.To keep your liver healthy.To heal your liver.To detox your bodyMy Video:  The Magic of Spirulina https://youtu.be/Y6nTjJgCZxEMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast2/The-Magic-of-Spirulina.mp3

TODAY'S SPONSOR:SoWell, the at-home Fasting Insulin Test! Why Insulin? When you go to the doctor they test glucose and HbA1C, but not INSULIN! Over 50% of the population suffers from Insulin Resistance and it is at the root of diabetes, and many other chronic diseases. Even if you ask your doctor for a fasting insulin test, they often REFUSE! If you get it, your doctor might say that anything below 23 is "fine" but ideally, you may not feel well unless it's somewhere between 2-5. SoWell's at-home fasting insulin test also tests: fasting glucose, HbA1C, Thyroid Stimulating Hormone, Vitamin B12, HDL Cholesterol, LDL Cholesterol and Triglycerides!Use the code DANI10 to save 10% on this incredibly informative test!____________________TODAY'S GUEST:"Traditional medicine only allows time and room for medication management. There's no time for lifestyle and nutrition management." Dr. Alexandra Sowa is a duel board-certified physician of internal medicine, specializing in metabolic health, and clinical instructor of medicine at NYU Langone. Dr. Sowa has served as a health expert for national media outlets and print publications like SiriusXM, CBS News, NPR, the New York Times, U.S. News, World Report, and more. In addition to her private practice in NYC, she is the founder of SoWell Health, a consumer metabolic health company. SoWell Health's foundational product, The Weight Biology Kit, is the first at-home lab kit to test for insulin resistance and other metabolic factors that make up your weight biology. You can learn more about Dr. Sowa and SoWell at getsowell.com.On today's episode we talk all about: Dr. Sowa's disillusion with mainstream medicineWhy nutrition needs to be the core of any health and weight loss planThe number 1 marker that tells you how to create a personalized health plan and how to uncover and get to the root causes of diseaseThe problems with the mainstream medical system according to a doctorThe outdated dogma Dr. Sowa was taughtDoctors don't get education on how to interpret fasting insulin testingWhy is fasting insulin so importantWhat is Insulin Resistance and where we got it wrong in traditional medicineWhat are the ramifications of Insulin ResistanceBy the time your A1C is high or by the time the blood sugar is high, insulin has been creeping up for 20 yearsPCOS is a disease of Insulin Resistance Benefits of metformin on insulin sensitivityTraditional ranges of Insulin vs Functional (Ideal) Ranges of InsulinWhat the HOMA/IR score is and why it's so importantStrategies to improve Insulin SensitivityThe alarming amount of people who have Insulin Resistance____________________Thank you for listening to the show!You can find me on Instagram @daniellehamiltonhealth and on Facebook at Danielle Hamilton Health.My website is daniellehamiltonhealth.com. Be sure to sign up for my *brand new* weekly newsletter to get all the best tips, coupon codes, and to be the first to know about my upcoming programs!If you are liking the show, please head to Apple Podcasts or iTunes to leave the show a *5-star rating* & a quick review! It helps the show to grow and lets me know what you're liking!Thank you for subscribing, rating, reviewing, sharing and reposting the show! I appreciate each and every one of you!

✔ Get your at home Diabetes And Heart test by using 30% off coupon code: LEAN30: http://trylgc.com/LiveLeanHeart. Thanks to LetsGetChecked for sponsoring this video. On today's episode of Live Lean TV, I'm sharing my personal experience on how I raised my good HDL cholesterol to boost my testosterone. Timestamps: 00:00 How I Raised My Good HDL Cholesterol To Boost My Testosterone 01:16 How To Test Your Cholesterol Levels At Home 03:17 Why Cholesterol Helps Boost Testosterone 04:41 Foods That Increase Good HDL Cholesterol 06:06 What Is Cholesterol? 07:07 HDL vs LDL Cholesterol 08:12 What Are Triglycerides? 09:31 How To Improve Your Cholesterol Levels Subscribe Here! http://bit.ly/SubLiveLeanTV Check Out Our Top Videos! http://bit.ly/LiveLeanTVTopVideos Read the blog here: https://bit.ly/3OBA2jV Listen to the podcast here: https://www.liveleantv.com/podcast WANT MORE DAILY TIPS ON HOW TO LIVE LEAN?: ✔ INSTAGRAM: http://www.instagram.com/bradgouthro ✔ INSTAGRAM: http://www.instagram.com/JessicaGouthroFitness ✔ INSTAGRAM: http://www.instagram.com/LiveLeanTV ✔ SNAPCHAT: http://www.snapchat.com/add/bradgouthro ✔ FACEBOOK: http://www.facebook.com/LiveLeanTV ✔ TWITTER: http://www.twitter.com/bradgouthro ✔ TWITTER: http://www.twitter.com/LiveLeanTV ✔ TIK-TOK: https://www.tiktok.com/@bradgouthro ✔ TIK-TOK: https://www.tiktok.com/@liveleantv #Cholesterol #Testosterone #LiveLeanTV About Live Lean TV: Welcome to Live Lean TV. The online fitness and nutrition show, hosted by Brad and Jessica Gouthro, teaching you how to LIVE THE LEAN LIFESTYLE 365 days a year. Watch hundreds of fat blasting & muscle building workouts, easy and delicious recipes, as well as fitness and nutrition tips to get you your dream body (and maintain it 365 days a year). Make sure you click the SUBSCRIBE button for new fitness and nutrition episodes every week! Business Enquiries: info@LiveLeanTV.com How I Raised My Good HDL Cholesterol To Boost My Testosterone (EAT THESE FOODS) | LiveLeanTV https://youtu.be/ukXSA_ierDw Live Lean TV http://www.youtube.com/LiveLeanTV

Each month for the past year we've offered our bloodsmart.ai group program. It's an opportunity to use machine learning to predict—from a pretty simple blood test—what is likely happening inside your body (and what might be going wrong) along with expert feedback on the results from NBT Scientific Director and Coach, Megan Hall and me. The program has been very popular, not to mention a lot of fun, and people are going through more than once to measure their ongoing progress. On this podcast, Megan provides detailed feedback on the bloodsmart.ai report belonging to NBT Coach Clay Higgins. What you'll hear is very similar to what goes on during our group coaching sessions. It's a review of exactly what's going well and where there's opportunity for improvement - along with specific steps to take right now to improve overall health, based on the data, symptoms, and personal history. If you'd like to participate in a group program please email NBT support for details and be sure to let us know where in the world you live so we can tailor our response to your needs. Here's the outline of this episode with Megan Hall and Clay Higgins: [00:00:33] Clay's combined bloodsmart.ai report. [00:05:13] Overall wellness score and PhenoAge. [00:07:30] Marker Detail View Page. [00:08:12] NutriSense continuous glucose monitoring. [00:12:03] Calculated red blood cell survival and HbA1C. [00:13:52] Eight Sleep. [00:16:33] Uric acid. [00:25:10] Potential oxidative stress: N. Acetyl Cysteine (NAC) may help. [00:26:58] Calcium a bit low; consider following up with a blood parathyroid test and/or supplement with magnesium. [00:32:56] HDL Cholesterol a little high and what that might mean. [00:34:26] Red blood cell indices and low oxygen deliverability suggest possible nutrient deficiencies. [00:35:53] Digestive enzymes: Thorne Biogest or Betaine HCl. [00:38:05] HomocysteX Plus. [00:40:33] Reticulocyte production index and RDW. [00:43:44] Low neutrophils (neutropenia) could suggest low copper level. [00:46:36] Nose to Tail. [00:48:00] Bloodsmart.ai forecasts. [00:48:32] Environmental toxin exposure; Quicksilver Blood Metals Testing. [00:51:53] Supporting detoxification: sauna, binders, supporting detox pathways. [00:53:45] Mitigating toxins in the environment. Skin Deep app; Think Dirty Shop Clean app. [00:55:59] Forecasted iodine deficiency; sea vegetables are a good source. [00:57:06] Forecasted issues with immune system/gut. [00:58:28] Designs for Health GI Revive. [00:59:35] Lucy Mailing, PhD; Lucy on previous NBT podcasts: 1, 2, 3. [01:01:49] Homocysteine forecasted to be high - B vitamins are important, as well as glycine, creatine. [01:01:50] Join our bloodsmart.ai group program to get Megan's feedback on your blood chemistry.  In the US, click here to get started. $198 includes blood testing, a bloodsmart.ai report, and access to 4 group coaching sessions with Megan. (Note: Residents of NY, NJ, RI and those living outside the US - pricing and availability varies. Please contact us for assistance.)

Statin is a medication to lower your cholesterol. This medication works by blocking a substance in your system that it needs to make cholesterol.  Based on 2018 statistics, over 35 million Americans are prescribed statins.  There are other drugs that many diabetics are prescribed that also increase your chances of getting diabetes or make things worse.I do not want anyone running home and throwing away their statin medication. That's not what this episode is about....but it's for raising awareness and letting you know that, lifestyle changes can make a huge impact on your health and your quality of life.  HIGHLIGHTSDefinition of Statin and how it works in your system.What is Cholesterol and its link with Diabetes.Where does Cholesterol comes from.Optimal levels of Cholesterol.LDL and HDL Cholesterol.What are Triglycerides.Side effects of Statins and their link to INSULIN RESISTANCE.Have you heard of Steroid Hormones?GOLD MEDAL QUOTES "I'm pretty sure most people don't even know that our body needs a certain amount of  cholesterol.""Did you know that statins can increase your glucose by as much as 12%?"LINKS OF INTERESTSign up to the Email list  to get notified when webinars and trainings come up.If you want to receive a FREE REPORT that helps you Improve Type 2 Diabetes & Boost Your Immune System find the clues in the episode.This report targets different areas of your health to improve your immune system while improving your diabetes.Follow  The Virgin Diabetic on Instagram and TikTok @thevirgindiabetic Get diabetes-friendly recipes and find some useful articles about diabetes at https://reversemydiabetes.net/blogVisit My Diabetes Concierge ProgramNeed someone to talk to about your Diabetes? Book a free consultation with Denise today https://reversemydiabetes.net/  Get The Virgin Diabetic Book https://amzn.to/3auCJl6Join us on Facebook for more info, discussions and articles https://www.facebook.com/reversemydiabetes/ 

This is the fourth and final episode of my four part series about dietary fats. Today I look at cholesterol, including the essential roles it plays in our bodies - it is a precursor for bile acids and for steroid hormones such as estrogen and testosterone - and its association with heart disease.I discuss the different types of cholesterol as it can be confusing and I disabuse the myth that dietary cholesterol causes high blood cholesterol.HOW YOU CAN SUPPORT THE PODCASTPlease tell your friends about the podcast and share it with them.Follow me on Instagram @vibrant_lives_podcastFollow my Facebook page: @vibrantlivespodcastIf you could rate and review the podcast on iTunes, that would be super helpful.

It’s time for another Jimmy Makes Science Simple on the LLVLC Show. Today Jimmy tackles a new study that shows how your cholesterol numbers might be a predictor for 91-DIVOC. “What is it about HDL Cholesterol that is providing protection from 91-DIVOC?” Jimmy Moore ⁣⁣ Spanish researchers looked at the associations of lipid (cholesterol) numbers with 91-DIVOC infection and severity. They examined total, LDL, triglycerides, and HDL cholesterol and concluded the most severe symptoms and outcomes from 91-DIVOC almost always had lower HDL and higher triglycerides along with higher small dense LDL particles. ⁣ READ THE FULL STUDY HERE: https://www.nature.com/articles/s41598-021-86747-5 ⁣ While the researchers did not make this conclusion, I noted that the best way to raise HDL cholesterol and lower triglyceride levels is with a well-formulated low-carb, high-fat ketogenic diet. Since we will all eventually get exposed to 91-DIVOC, eating keto could be a nice prophylactic for dealing with this virus without the need for any unnecessary sticking of a needle in your body. Combine this with the previous research on increasing vitamin D levels as well as lowering insulin and glucose, it looks like the ketogenic lifestyle is perfectly suited to protect you through the production of a robust innate immune system.

Dr. Mark Houston discusses HDL Cholesterol with Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast.  Also check out the video version on YouTube at https://www.youtube.com/user/weitzchiro/]   Podcast Highlights   Dr. Mark Houston is an internal Medical […]

In this episode:  Non-fasting tests are clinically useful Request Total Cholesterol, HDL-Cholesterol, Triglycerides and Non-HDL-Cholesterol An LDL-Cholesterol alone is not enough   Host: Dr David Lim | Total time: 25 mins Guest: A/Prof David Sullivan, Physician, Chemical Pathologist, Department of Clinical Biochemistry, Royal Prince Alfred Hospital; Associate Professor, Faculty of Medicine, University of Sydney Central Clinical School   Register for our upcoming FREE WEBCAST  Tuesday 16 March 2020 | 7:00pm-9:00pm AEDT Click here to register now! See omnystudio.com/listener for privacy information.

Commentary by Dr. Valentin Fuster

Welcome to Doctor Warrick's Podcast Channel. Warrick is a practicing cardiologist and author with a passion for improving care by helping patients understand their heart health through education. Warrick believes educated patients get the best health care. Discover and understand the latest approaches and technology in heart care and how this might apply to you or someone you love.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.27.356873v1?rss=1 Authors: Haile, B., Wolde, M., Gebregziabiher, T. Abstract: Abstract Background: Hypertension is a silent killer that requires long term management to avoid complications. It is one of major public health problem in developing counties like Ethiopia. Hypertension increases the risk of morbidity and mortality and has negative consequences on the cognitive and physical fitness of productivity in adults. Objective: To assess fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile among hypertensive patients and non-hypertensive participants at wolaita sodo teaching and referral hospital. Methods: A comparative cross-sectional study was conducted from December 2019 to February 2020. On the study a total of 156 study participants (78 cases and 78 controls) were involved. Each study participant, after signing informed consent, interviewed about the socio-demographic and anthropometric characteristic features. Then 5ml of the blood sample was collected from each 78 patients with hypertension and each 78 samples from apparently healthy subjects from WSUTRH during the period. Fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile level were measured in each group. The Data were analyzed by using Epi data version 3.1 and SPSS version 21.0 software (IBM Corporation, USA) and results were summarized using means and percentages and presented by using figures and tables. P-value < 0.05 was considered to be significant at 95% confidence level. Any abnormal laboratory results of study subjects dispatched and communicated with physicians for better management. Results: The mean age of hypertensives and control study groups were 50 {+/-} 10.0 and 51 {+/-} 11.3 years respectively. The body mass index of hypertensives and control study groups were 53.4% and 34.2% overweighed respectively. The mean {+/-} SD of fasting blood glucose, total cholesterol, LDL-C, TG, RFT were significantly increases while serum sodium, calcium, albumin, and HDL- Cholesterol significantly decreased in hypertensives when compared with non-hypertensives and serum potassium was no statistical significance among case and control groups. Conclusion: In present study, we observed that the hypertensive group was at risk for developing biochemical alteration in creatinine, urea, fasting blood glucose, lipid profile, electrolytes, and albumin test parameters with an increased period of time. Recommendation: Regular measurements of biochemical parameters strongly needed for hypertensive patients. Copy rights belong to original authors. Visit the link for more info

Today, we chatted with Gil Carvalho, MD, PhD is a physician, research scientist, science communicator, speaker and writer. He is most well-known for his nutrition channel on YouTube, “Nutrition Made Simple.” We take a deep dive into cholesterol, uncovering its function and the best ways to optimize cholesterol levels. We also tackle some of the greatest myths about cholesterol, and what the numbers on your lipid panel really mean!You can get in touch with Dr. Carvalho here:YouTube: https://www.youtube.com/channel/UCosmc75v-B2Dk7GWyEyFFMwTwitter: https://twitter.com/NutritionMadeS3Facebook: https://www.facebook.com/DrGilCarvalho/Also, check out his cholesterol-lowering menu here! www.thecholesterolchallenge.comDon’t forget! Get 40% your first order of Life Boost Coffee by using promo code “artofeating” at lifeboostcoffee.com at checkout! Use this link to streamline the process: https://lifeboostcoffee.com/pages/healthy-coffee-ot2e-jhopkins?oid=1&affid=49With Culiraw, guilt-free desserts are possible! They are made of natural organic ingredients that provide your body with fiber, minerals, vitamins and enzymes, sweetened with dates and agave only. Use code is “aoepodcast” for 10% discount at checkout!Subscribe to Dr. Esposito’s YouTube Channel: https://www.youtube.com/channel/UCHRpZFrFsbJIk5fbNIkj4pQ?sub_confirmation=1 Sign up for our newsletter at evokhealth.com and get our 14 Kick-start Recipes & Kitchen Secrets! Feel free to reach out to us at artofeatingpodcast@gmail.com. You can also follow us on Instagram @artofeatingpodcast. To reach your hosts, you can find Dr. Esposito at:Email: drvincentesposito@gmail.comIG: @vinespositomsdcTwitter: @VinEspositoMSDC Web: insideouthealthwellness.com You can find Dr. Kali at:Web: drkali.com IG: @dr.kali

In this episode, we will go over three articles describing the affect genetics play on cardiovascular disease, as well as sleep's mitigating role. We will also discuss how non-HDL cholesterol affects heart disease risk. Finally, we briefly discuss a study on extreme sugar consumption and its impact on male fertility. (2:28) Genetics & Sleep: Mengyu Fan, Dianjianyi Sun, Tao Zhou, Yoriko Heianza, Jun Lv, Liming Li, Lu Qi. Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. European Heart Journal, 2019; DOI: 10.1093/eurheartj/ehz849 (11:32) Non-HDL Cholesterol: Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. The Lancet, 2019; DOI: 10.1016/S0140-6736(19)32519-X (24:00) Sugar on Fertility: Daniel Nätt, Unn Kugelberg, Eduard Casas, Elizabeth Nedstrand, Stefan Zalavary, Pontus Henriksson, Carola Nijm, Julia Jäderquist, Johanna Sandborg, Eva Flinke, Rashmi Ramesh, Lovisa Örkenby, Filip Appelkvist, Thomas Lingg, Nicola Guzzi, Cristian Bellodi, Marie Löf, Tanya Vavouri, Anita Öst. Human sperm displays rapid responses to diet. PLOS Biology, 2019; 17 (12): e3000559 DOI: 10.1371/journal.pbio.3000559 YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6 Patreon: bit.ly/2OBBna0

JACC: Case Reports - Audio Summary by Dr. Julia Grapsa

Commentary by Dr. Valentin Fuster

Chronically Low HDL Cholesterol Levels From TRT It's very common for men on TRT to have really low HDL cholesterol levels. I have the same issue. Anyone on exogenous androgens, regardless if it's SARMs, steroids, or prohormones, will likely have a suboptimal lipid profile.…

High-density lipoprotein or HDL is one of the most important of the lipoproteins in most species and there is evidence that points towards a role of HDL in normal immune function.  A paper appearing in the May 2019 issue of Clinical Chemistry tested the hypothesis that concentrations of HLD cholesterol are associated with risk of autoimmune disease. That study from the Copenhagen General Population Study and the Copenhagen City Heart Study included over 100,000 individuals.  We are pleased to have the senior author of that paper with us today, Dr. Borge Nordestgaard. 

Timestamps: 00:45 How strong is “strong enough” for non-barbell sports? 06:55 How do you hold your athletes accountable? 12:37 HDL Cholesterol 16:20 SARMs 19:49 Cutting, Bulking, and Maintenance phases 23:20 Pharmaceutical nocebos 27:45 Should I get hyped up for lifts or stay calm? 34:40 Athletic Training vs. Pain Science For more of our stuff: Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vaness_barbellmedicine @untamedstrength @mike_barbellmedicine @derek_barbellmedicine @hassan_barbellmedicine Email: info@barbellmedicine.com Supplements/Templates/Seminars/Apparel: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/ Newsletter: eepurl.com/cpqB3n

In this episode, I discuss how to increase your HDL ("good") cholesterol. Study: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.550.153&rep=rep1&type=pdf HRR video: https://www.youtube.com/watch?v=PUAFnWgE2Xg&feature=youtu.be YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6 Patreon: bit.ly/2OBBna0

Dr. Morrow’s Show Notes on Statins Before talking about statins, we should talk about high cholesterol. What qualifies as high cholesterol? Has changed a lot over the years. Now, it is LDL > 130 or HDL < 40 if you have no family history of heart disease. It is an LDL > about 75 if […] The post To Your Health With Dr. Jim Morrow: Episode 3, The Truth About Statins appeared first on Business RadioX ®.

A new study suggests that too much "good" cholesterol may be just as bad as too little. Dr. Sanaz Majd joins Nutrition Diva to sort out what this new research means for our heart health and risks. Read the transcript at https://www.quickanddirtytips.com/health-fitness/medical-conditions/can-you-have-too-much-good-hdl-cholesterol Check out all the Quick and Dirty Tips shows: www.quickanddirtytips.com/podcasts FOLLOW NUTRITION DIVA Facebook: https://www.facebook.com/QDTNutrition/ Twitter: https://twitter.com/NutritionDiva

Hey Weight Loss Nation! The Weight Loss Nation Today is 5 Minute Snack Day! With Football Season in full swing, Baseball post-season coming, as well as Hockey, it's a Sports        FAN-atic Season! This 5 Minute Snack is going to be the HIT of the Party! I know it will. I got this idea from a Party I recently went to!  So let's get started   Ingredients: 1. Cherry Tomatoes (1 Cup) 2. Mozzarella Cheese (2 oz) 3. Fresh Basil Leaves (2) 4. Sea Salt 5.  8-10 Toothpicks   Instructions: 1. Wash the Cherry Tomatoes and cut them in half. 2. Take half a Cherry Tomato & stick it on a toothpick. 3. Add a cut piece of Mozzarella Cheese to the same toothpick on top of the tomato. 4. Add a piece of Basil Leaf on top of the Mozzarella. 5. Add the other half of the Cherry Tomato to the toothpick, (round end facing the edge of toothpick)  6. Sprinkle some Sea Salt on top of the Caprese Sandwich. 7. Stick the entire toothpick in your mouth and pull off the Caprese Sandwich.  8. Chew well & Enjoy!   Cherry Tomatoes & Mozzarella   There are many food marriages out there: Peanut Butter & Jelly Peanut Butter & Chocolate Bacon Wrapped Scallops soooo many more.......... Cherry Tomatoes & Mozzarella is another food marriage, made in Heaven........AND......is Healthy for you too! Tomatoes are rich in Vitamin C, Potassium & LYCOPENE, the Anti-Oxidant that gives Tomatoes their Rich RED color. Lycopene Fruit & Veggetables are my Favorite....because they are part of the Weight Loss Nation "Pac Man" Family......which will Search, Fight & Destroy Bacteria, Viruses....and Anti-Oxidant Cells that can cause Cancer. Eating Tomatoes may reduce your risk of Cancer and Heart Disease.....AND help Fight off Illnesses! Mozzarella Cheese is high in Protein, Calcium & Vitamin B12. Mozzarella may also decrease Heart Disease risk by raising your levels of HDL Cholesterol, which is the "beneficial" cholesterol in your body. This Delicious "Caprese" Mini Sandwich Snack...... ALL 8-10 of them, is only around ....... 200 calories! You have to like that Nation! You will LOVE this SNACK! Bring Mini Caprese Sandwiches to EVERY Party or Event you go to this Holiday Season. It will be a Major Hit!   Want to learn more about Weight Loss Nation?   Go to the Website -  Weight Loss Nation I would love for you to take a few minutes and give Weight Loss Nation a Rating & Review on Apple Podcasts or Stitcher. When you give Weight Loss Nation a review...... it helps others find Weight Loss Nation. So......if I'm delivering content that you are enjoying, Please "Click" on this link -  https://goo.gl/6hAuhG Leave an Honest Review! This helps me to keep giving you Support, Recipes, Restaurant Reviews & Guests that you enjoy listening to...... Thanks for listening to today's "5 Minute Snack."   Hey Weight Loss Nation! www.TheWeightLossNation.com If you are ready to "finally" lose weight and keep it off forever, you need to "join Weight Loss Nation." You know the adage....."It takes a village to raise a child." The concept is the same with weight loss! Would you rather continue "yo-yo dieting" by yourself and not be able to go out to a restaurant with friends, since you know you will "struggle" with food choices? Are you happy with losing weight only to gain it back again? Do you have too much "stress" in your life? I've said all of those things and I've had every excuse in the book on why I couldn't keep weight off. Or....... Would you like to be part of a "Village" of people, who are just like you and will be there to support you every single day in a private community? Weight loss Nation has a collaboration of experts in the fields of Nutrition, Mindset, Movement, Weight Loss, Yoga, Fitness, Meditation, Emotional Eating and Post Traumatic Stress! When you become a member of Weight Loss Nation, you have access to these experts to answer your questions! Weight Loss Nation Members* have access to recipes, cooking videos and exercise videos. Weight Loss Nation participates in “Meet Ups” in the Tampa Bay, Florida area. Our Private Facebook Forum is a "no judgement zone," where you can feel safe and comfortable in sharing your comments and feelings. So.....what are you waiting for? Go to www.TheWeightLossNation.com and take the life-long journey with me and finally lose the weight forever! Members* are Weight Loss Nation Pro Support and/or Lifetime Members https://goo.gl/aJrpZT    Nutrition Disclaimer These show notes are written and produced for informational purposes only. Statements within this site have neither been evaluated or approved by the Food and Drug Administration nor a health practitioner. This site is not intended to diagnose, treat, cure or prevent any disease. Content should not be considered a substitute for professional medical expertise or treatment. The reader assumes full responsibility for consulting a qualified health professional regarding health conditions or concerns, and before starting a new diet or health program. The writer(s) and publisher(s) of this site are not responsible for adverse reactions, effects, or consequences resulting from the use of any recipes or suggestions herein or procedures undertaken hereafter. This website, www.TheWeightLossNation.com, occasionally offers nutritional information for recipes contained on this site. This information is provided as a courtesy and should not be construed as a guarantee. This information is a product of online calculators such as MyFitnessPal.com, CalorieCount.com, Nutrifox.com, as well as from other sites.  Although TheWeightLossNation.com attempts to provide accurate nutritional information, these figures should be considered estimates. Varying factors such as product types or brands purchased, natural fluctuations in fresh produce, and the way ingredients are processed change the effective nutritional information in any given recipe.   Different online calculators provide different results depending on their own nutrition fact sources and algorithms. Furthermore, I am neither a chef nor a cook and I don't pretend to be. I'm also not great in Math! Under no circumstances will Weight Loss Nation LLC. be responsible for any loss or damage resulting for your reliance on nutritional information, or any other information from this site, or the www.TheWeightLossNation.com website. Information is offered as an opinion and information may not be accurate. Due your own due diligence and make your own conscious decisions.

Jane:                                     Hi, everyone. Welcome to Episode 18 of Getting Personal: Omics of the Heart. I'm Jane Ferguson, and this podcast is brought to you by the Circulation: Genomic and Precision Medicine Journal and the American Heart Association Counsel on Genomic and Precision Medicine. It is July 2018, which means that the best possible place to be listening to this episode is at the beach, but failing that I can also recommend listening on planes, during your commute, while exercising or while drinking a nice cup of tea.                                                 So before I get into the papers we published this month, I want to ask for your help. If you're listening to this right now, hi, that means you, we're a year and a half into podcasting and I would love to know what content you like and where we could improve things. We have a poll up on Twitter this week, and I would really appreciate your input. If you're listening to this a little bit later and miss the active voting part of the poll, you can still leave suggestions.                                                 Okay, so what I would like you to do right now is to go to Twitter. You can find us as Circ_Gen and locate the poll. If you don't already follow us on Twitter, go do that now too. We want you to let us know what content we should focus on and what is most useful to you, so go ahead and pick your favorites from the options and also please reply or tweet at us with other thoughts and suggestions.                                                 Options include giving summaries of the recent articles like I'm about to do later this episode, conducting interviews with authors of recently published papers, interviews with people working in cardiovascular genomics, broader topics. For example, to get their insight on career paths and lessons learned along the way.                                                 And something we have not done yet on the podcast but are considering, would be to record podcasts that focus on particular topics in genomics and precision medicine. These could give some background on an emerging field or technology and we could talk to experts who are leading particular innovations in the field. So, if that sounds good to you, let me know! If you're not on Twitter, I don't want to exclude you, so you can email me at jane.f.ferguson@vanderbilt.edu and give me your thoughts that way. I'm looking forward to hearing from you.                                                 Okay, so on to the July 2018 issue of Circ.: Genomic and Precision Medicine. First up is a PhWAS from Abrahim Rao, Eric Ingelsson, and colleagues from Stanford. The discovery of the PCSK9 gene as a regulator of cholesterol levels has led to a new avenue of LDL lowering therapies through PCSK9 inhibition. However, some studies suggest that long term use of PCSK9 inhibitors could have adverse consequences. Because of the long follow-up time required, it will take many more years to address this question through clinical studies. However, genetic approaches offer a fast and convenient alternative to address the issue.                                                 In this paper, entitled: "Large Scale  Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke," the authors use genetic and phenotype data from over 300,000 individuals in the UK BioBank to address whether genetic loss of function variants in PCSK9 are associated with phenotypes including coronary heart disease, stroke, type II diabetes, cataracts, heart failure, atrial fibrillation, epilepsy, and cognitive function.                                                 The missense variant RS11591147 was associated with protection against coronary heart disease and ischemic stroke. This SNP also associated with type II diabetes after adjustment for lipid medication status. Overall, this study recapitulated the associations between PCSK9 and coronary disease, and revealed an association with stroke.                                                 Previous studies suggested use of LDL lowering therapies may increase risk of cataracts, epilepsy, and cognitive dysfunction, but there was no evidence of association in this study. Overall, this study provides some reassurance that the primary effect of PCSK9 is on lipids and lipid related diseases, and that any effects on other phenotypes appear to be modest at best. While a PhWAS can't recapitulate a clinical trial, what this study indicates is that PCSK9 inhibition is an effective strategy for CVD prevention, which may confer protection against ischemic stroke and does not appear to convey increased risk for cognitive side effects.                                                 Next up we have a manuscript form Jason Cowan, Ray Hershberger, and colleagues from Ohio State University College of Medicine. Their paper, "Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Non-segregating LMNA Pedigrees," explored pedigrees of apparent LMNA related cardiomyopathy identifying family members who manifested disease, despite not carrying the purported causal LMNA variant. Of 19 pedigrees studies, six of them had family members with dilated cardiomyopathy who did not carry the family's LMNA mutation. In five of those six pedigrees, the authors identified at least one additional rare variant in a known DCM gene that was a plausible candidate for disease causation.                                                 Presence of additional variants was associated with more severe disease phenotype in those individuals. Overall, what this study tells us is that in DCM, there is evidence for multi-gene causality and bilineal inheritance may be more common than previously suspected. Future larger studies should consider multi-genic causes and will be required to fully understand the genetic architecture of DCM.                                                 Yukiko Nakano, Yasuki Kihara, and colleagues from Hiroshima University published a manuscript detailing how HCN4 gene polymorphisms are associated with tachycardia inducted cardiomyopathy in patients with atrial fibrillation. Tachycardia induced cardiomyopathy is common in subjects with atrial fibrillation, but the pathophysiology is poorly understood. Recent studies have implicated the cardiac hyperpolarization activated cyclic nucleotide gated channel gene, or HCN4, in atrial fibrillation and ventricular function.                                                 In this paper, the authors enrolled almost 3,000 Japanese subjects with atrial fibrillation, both with and without tachycardia-induced cardiomyopathy, as well as non-AF controls. They compared frequency of variants in HCN4 in AF subjects with or without tachycardia-induced cardiomyopathy, and found a SNP, RS7164883, that may be a novel marker of tachycardia-induced cardiomyopathy in atrial fibrillation.                                                 Xinyu Yang, Fuli Yu, and coauthors from Tianjin University were interested in finding causal genes for intracranial aneurysms, and report their results in a manuscript entitled, "Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms." They sequenced the genomes of 20 Chinese intracranial aneurysm patients to search for potentially deleterious, rare, and low frequency variants. They found a coding variant in the ARHGEF17 gene which was associated with associated with increased risk in the discovery sample, and which they replicated in a sample of Japanese IA and in a larger Chinese sample.                                                 They expanded this to other published studies, including individuals of European-American and French-Canadian origin and found a significantly increased mutation burden in ARHGEF17 in IA patients across all samples. They were interested in further functional characterization of this gene and found that Zebra fish ARHGEF17 was highly expressed in blood vessels in the brain. They used morpholinos to knock down ARHGEF17 in Zebra fish, and found that ARHGEF17 deficient Zebra fish developed endothelial lesions on cerebral blood vessels, and showed evidence of bleeding consistent with defects in the vessel. This study implicates ARHGEF17 as a cerebro-vascular disease gene which may impact disease risk through effects on endothelial function and blood vessel stability.                                                 Sumeet Khetarpal, Paul Babb, Dan Rader, Ben Voight, and colleagues from the University of Pennsylvania used targeted resequencing to look at determinants of extreme HDL cholesterol in their aptly titled manuscript, "Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of HDL Cholesterol in Humans." Stay tuned because we're gonna hear more about this paper from the first author Dr. Sumeet Khetarpal later this episode.                                                 Rounding out this issue we have a Perspective article from Chris Haggerty, Cynthia James, and coauthors from Geisinger and Johns Hopkins Medical Center entitled, "Managing Secondary Genomic Findings Associated With Arrhythmogenic Right Ventricular Cardiomyopathy: Case Studies and Proposal for Clinical Surveillance." In this paper the authors discuss the challenges for returning findings from clinical sequencing for arrhythmogenic right ventricular cardiomyopathy, presenting case studies exemplifying these challenges. They also propose a management approach for returning clinical genomic findings, and discuss new innovations in the light of precision medicine.                                                 We also published a review article by Pradeep Natarajan, Siddhartha Jaiswal, and Sekar Kathiresan from MGH on "Clonal Hematopoiesis Somatic Mutations in Blood Cells and Atherosclerosis", which discusses recent advances in our knowledge on the role of somatic mutations in cardiovascular disease risk.                                                 Finally, we have an update on some pharmacogenomics research into CYP2C19 Genotype-Guided Antiplatelet Therapy by Craig Lee and colleagues which we published a few months ago. Dr. Lee was also featured on Podcast episode 15 in April of this year.                                                 Jernice Aw and colleagues from Khoo Teck Puat Hospital, Singapore shared from complimentary data from their sample of 247 Asian subjects which found the risk for major adverse cardiovascular events was over 30-fold greater for poor metabolizers, as defined by CYP2C19 genotype on clopidogrel, as compared to those with no loss of function allele.                                                 You can read that letter and the response from Dr. Lee and colleagues online now. And, as usual, all of the original research articles come with an editorial to help give some more background and perspective to each paper. Go to circgenetics.ahajournals.org to find all the papers and to access video summaries and more.                                                 Our interview is with Dr. Sumeet Khetarpal who recently completed his MD-PhD training at the University of Pennsylvania, and is currently a resident in Internal Medicine at Massachusets General Hospital. Sumeet kindly took some time out from his busy residency schedule to talk to me about his recently published paper, and to explain how molecular inversion probe target capture actually works.                                                 So I am here with Dr. Sumeet Khetarpal who is co-first author on a manuscript entitled, "Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans."                                                 Welcome Sumeet, thanks for taking the time to talk to me. Dr. Khetarpal:                    Thank you so much Dr. Ferguson, it's really a pleasure to talk to you today. Jane:                                     Before we get started, maybe you could give a brief introduction on yourself and then how you started working on this paper. Dr. Khetarpal:                    Sure, so this work actually was a collaboration that came out at the University of Pennsylvania that I was involved with through my PhD thesis lab, my mentor was Dan Rader, and also a lab that is a somewhat newer lab at Penn, Benjamin Voight's lab which is a strong sort of computational genomic lab.                                                 This work actually highlights the fun of collaborating within your institution. We had, for some time, been interested in developing a way to sequence candidate genes. Both known genes and also new genes that have come out of genome-wide association studies that underlie the extremes of HDL cholesterol, namely very high cholesterol versus low HDL cholesterol. We've been looking for a cost-effective and scalable way to do this.                                                 Independently, Ben, who is very interested in capturing the non-coding genome, was interested in developing a method to better understand the non-coding variation, both common and rare variation that may be present at all of these new loci that have come out for complex traits such as HDL.                                                 We, at some Penn event several years ago, were talking about our common interest and Ben had actually identified this work that had come out of J. Shendure's lab at the University of Washington. A paper by the first author, Brian O'Rouke, in Science in 2012 in which they had developed an approach that involved molecular inversion probes, or MIPs, to capture regions of the genome related to target the gene that they were interested in studying for autism-spectrum disorders.                                                 They had applied this largely to coding regions of, I think, almost 50 genes and almost 2,500 patients with the feedback to do deep, targeted sequencing. So our thought was, well, we could try to apply this approach and adapt it to capture non-coding regions, and also see if we can expand the utility of this approach to study the phenotypic extremes of a complex trait such as HDL cholesterol. Jane:                                     Yeah, that's really cool. I love how you saw this method in a totally different application and then realized that there was expertise at Penn that you could bring together to apply this in a different way.                                                 I'd love to hear more about this MIP, the molecular inversion probe. How does it work? How difficult is it to actually do? Is it very different from normal library preparation for sequencing or is it something that's actually relatively easy to apply? Dr. Khetarpal:                    These MIP probes are oligonucleotide probes that capture your region of interest by flanking them and capturing by gap filling. There's a method to capture parts of the genome in a library-free way. They do ultimately involve barcoding the way traditional library-based target capture does and then deep sequencing.                                                 But the most impressive feature about them is just that they're very scalable. I think in the original paper by O'Rouke and colleagues they were able to sequence their set of genes and their set of samples at about a sample preparation cost of $1 per sample, and we were actually able to do about the same for our study.                                                 The main utility of the approach is just the economic scalability, and the ability to customize your panel to capture several regions of the genome that are adjacent to each other. Jane:                                     Right, so how many genes or regions can you multiplex at the same time? Is it just one prep, like you just design all of your oligos, you put them all together in one reaction, or are you doing separate reactions for each region? Dr. Khetarpal:                    We're actually doing all of our oligos together. In our case, I think it ended up being around the order of almost 600 oligos together to capture our ultimately 50kB of genomic territory that we wanted to capture. Really, our study was kind of a pilot experiment where we picked a few genes or regions of high interest to us, both known genes that effect HDL and also those that have been implicated in genome-wide association studies that were of high interest to our labs.                                                 I think that this approach could actually be expanded to capture much more genomic territory in a single capture reaction. We sort of touched the surface probably of what we could do. Jane:                                     Wow, that's cool! And then for sequencing it, I guess it's really just a function of how many samples you wanna multiplex and how much you want to sequence from each region. So I suppose the way you did it, you had about 50kB and then you had over 1,500 participants and you were able to do those on a single HiSeq run, right? Dr. Khetarpal:                    Right. Jane:                                     So I suppose if you'd done more genetic regions, you would've had fewer people and vice versa so you can balance that out depending on if you're having more samples or more genomic regions to sequence. Dr. Khetarpal:                    Exactly, in certain ways the design of our experiment we had a limited sample size that did afford us some luxury in terms of knowing that we would have deep coverage of the region that we were targeting. I think that's always a critical question in sort of targeted or just sequencing in general. The balance between the number of regions that you want to sequence and the number of samples you want to sequence is going to dictate what your sequencing depth with be. Jane:                                     Right, okay so I guess if we go on to what you actually found, how'd you pick this? You picked seven regions which encompasses eight candidate genes for HDL, so how did you select those? Dr. Khetarpal:                    The population that we were studying, the samples we were looking to sequence were largely individuals which fall into two bins if you will. One was extremely high HDL cholesterol which we're defining as the greater than the 95th percentile, but really there was a range within that population that spanned individuals with probably greater than the 99th percentile of HDL.                                                 We were hoping as a proof of principle effort to identify variation in genes that were known causes of high HDL cholesterol in prior studies of Mendelian genes for HDL. So genes such as LIP gene which encodes endothelial lipase or CETP or SCARB1, these 3 genes are, at this point, well-known genes that loss of function mutations are associated with extremely high HDL. We thought that capturing some of those genes would potentially both provide a level of validation for the approach, hypothesizing that individuals with high HDL would be enriched with these genes, but also may allow us to find new variants in these genes or also non-coding variants which has not previously been studied before.                                                 Some of the genes came out from that line of thinking, then some of the other genes happened to be genes that in the Rader laboratory we had a vested interest in understanding the genetic variation that might link the genes to HDL, which may not have necessarily come out before.                                                 For example, the gene GALNT2 is one of the first g-loss implicated novel genes for HDL, novel as in the earliest g-loss study for plasma lipids had identified that gene as associated with HDL but it never had come out before as being so. Our laboratory was very interested in better understanding the genetic relationship between genes such as GALNT2 and several of the others such as CCDC92 and ZNF664 with HDL.                                                 It ended up being a hodge-podge or a sampling of genes that had at some level been implicated with HDL, but really it's just a proof of principle that this method could work for both identifying variation in known genes and also less studied ones. Jane:                                     You validated the MIP genotyping by exome genotyping, and then saw concordance of over 90%, is that lower than you were expecting? Was it about what you were expecting based on these two different methods of genotyping? Dr. Khetarpal:                    Yes, I think we were expecting somewhere on the order of 90 plus percent. It's hard to know why we just hit that, we likely would've benefited from being able to genotype all of the individuals by the exome chip that we had sequenced as well, where we were able to validate in about two-thirds of those individuals.                                                 It's hard to know exactly what the cause of the about 10% discordance rate might be, whether it's just in certain samples the genotyping quality was perhaps on the border of being valid or the sequencing quality. Jane:                                     Right, I'm wondering sort of with the MIP, what's the gold standard? Is the XM chip genotyping still the gold standard and the MIP maybe is more error-prone, or perhaps the other way around? Or is it you can't tell at this point which is the true genotype and which is an error potentially for those discordant ones? Dr. Khetarpal:                    Certainly whenever there's a new sequencing methodology that is proposed I think it's critical to have some sort of validation. We happened to cover regions that would span the genome enough that we had XM chip genotyping in a large subset, that that might be the best approach. But if you had a limited number of regions or variance that you were interested in one could imagine also doing Sanger sequencing as the tried and tested validation approach. Of course it becomes not so scalable at a certain point.                                                 Certainly we would say that the MIPs, while the method has been developed and expanded by the Shendure lab, our hope is that through our studies maybe it will be applied further. It's still very much a new approach and so validation is key. Jane:                                     Very important. What do you think was the most exciting finding that came out of this, after you analyzed the data, what were you most excited about seeing? Dr. Khetarpal:                    The critical finding for us, which I think implies the utility of the approach, was just the validation of four of the loci that we had studied. Validation in our cohort of known genome-wide significant associations for HDL that had been published previously in almost 200,000 individuals in terms of sample size, in our experiment involving just about 1,500 people we were able to find consistent associations of those same variants that segregated with low versus high HDL. Directionally consistent with the large genome-wide association studies.                                                 I think the value of this finding is really just to emphasize the utility of the case control design in these phenotypic extremes, in addition to the overarching goal of our study, which was in a way that perhaps provides the most validation of the approach in terms of concordance with prior known studies. Jane:                                     So if somebody was listening to this and was trying to decide should they use MIP for a study they have in mind, should they use another technique? Based on your experience, what would you recommend? Dr. Khetarpal:                    I think in our current stage it's a very exciting time because we're just seeing whole genome sequencing really take off and being used at scale to ask critical questions about non-coding variation as it relates to both disease and complex traits. I don't think we're quite there yet with being able to apply that approach in a cost effective manner. The ability to annotate and analyze that data is still at it's infancy. The utility of the MIPs is that it provides a very cheap alternative.                                                 I can say from my experiences actually doing the capture and preparation from sample to sequencer stage that it's a very easy to use methodology that is very fast and cheap. That if one is really interested in a handful, or more than a handful, of candidate genes and their non-coding regions as it relates to a trait or disease of interest, it may not be the era for going full on with whole genome sequencing, especially at the current cost. That's where I think the MIPs really come in to be very useful. Jane:                                     It sounds great, is there anything else that you'd like to mention? Dr. Khetarpal:                    Just to say that we recognize it's a relatively small study as our pioneer approach with this method but that the Rader lab and Voight labs are actively pursuing larger applications of this to study, not only HDL, but other complex traits, such as diabetes, in much larger populations. I can't overemphasize how easy of a method it is to apply, but also that I think a bigger take home of this study for me as a very recent graduate student working in a very collaborative institution the ability of two laboratories to come together with different sets of expertise to try to tackle a problem that I think goes beyond the individual science. For any human geneticist how to find the variation you're interested in and not break the bank is kind of at the core of what we do, and so I think it was very fun to be part of this collaboration and our hope is that the outcome of it is a method that can be useful for many people, both in our field and beyond. Jane:                                     I think it's great and I'm hoping this will inspire a lot of other people to try this method and see if it can work for them. So, congratulations on the study, it's really nice work. Dr. Khetarpal:    Thank you so much!                                                                                                                                       Jane:                                     That's all I have for you for July, thanks for listening. Send me your thoughts on the podcast via Twitter or email, or leave us a review in Itunes. I look forward to talking to you next month.  

"I ate over 450 grams of fat and I watched my cholesterol levels DROP!"... Not something you'd expect to hear someone say, not to mention actually happen in a healthy body. For decades we've been told that saturated fat and cholesterol are dangerous for you, causing heart disease, clogging the arteries, and making you diabetic. However, new research over the past few years has disputed this notion as we gradually improve our understanding of cholesterol. In fact, people with higher levels of cholesterol have a lower risk of heart disease, whereas people with lower cholesterol have increased mortality rates. How crazy is that? People who go on a low carb high fat diet tend to see an increase in cholesterol as well, in both the LDL (the "bad") and HDL (the "good"). However, their triglyceride levels tend to drop, which prevents them from becoming diseased.  That's the topic of today's Body Mind Empowerment Podcast with Siim Land. Our guest is Dave Feldman who's an engineer, a citizen scientist, and a low carb advocate. His research on cholesterol in ketogenic diets has revealed a lot of insight into the functioning of this essential nutrient that even professional medical practitioners are beginning to implement.  Topics Discussed: What is the Role of Cholesterol - 04:18 Does Cholesterol Clog Your Arteries - 08:17 Difference Between LDL and HDL Cholesterol - 11:50 What Is Remnant Cholesterol - 15:02 Why Your Cholesterol Can Go Up on a Ketogenic Diet - 20:00 What is the Feldman Protocol - 25:08 Are You a Lean Mass Hyper Responder - 46:20 Why Doctors Are Afraid of Cholesterol Still - 57:00   And much more... Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Download mp3  Watch the podcast on YouTube   Click Here to Watch the Conversation on Video!   Show Notes Dave Feldman's Cholesterol Code Website Keto Fit Program Simple Keto Video Course Blog Post: How to Eat Organ Meats Without Disgust Ancestral Supplements Organ Meat Supplements Podcast episode #5 The 3 Stages of the Ketogenic Diet Keto // IF Program Perfect Keto Exogenous Ketones (Use the code SIIMLAND) Coaching   P.S. The OURA Ring is coming out with their 2nd generation ring in a few weeks. If you want to get a -$75 discount Use the code SIIMLAND at www.ouraring.com    Stay Empowered Siim   #health #dentalhealth #paleo #keto  

Host: Alan S. Brown, MD, FNLA A paradigm shift in the management of lipid disorders has been witnessed of late based on evidence reviews by the AHA and the ACC. Where the clinical dogma once focused on targeting specific lipoproteins, clinicians are now trending toward using appropriate dosages of statins for lowering non-HDL cholesterol. What are the ramifications of this change in approach, and how does the NLA weigh in on recommendations for targets and goals? To address these and other questions, host Dr. Alan Brown welcomes Kevin Maki, PhD, FNLA, CLS, Chief Science Officer for Midwest Center for Metabolic and Cardiovascular Research and Adjunct Faculty in Biostatistics and Applied Epidemiology at DePaul University, Chicago, IL.

Dr. Nina Radford, head of cardiology at the Cooper Clinic, talks with Todd Whitthorne about the recent study published in May 2012 in the Lancet that questions whether raising HDL cholesterol is beneficial. A text transcript of the interview is avalable on our blog here.

Guest: Terry Jacobson, MD Host: Larry Kaskel, MD Dr. Terry A. Jacobson explains to host Dr. Larry Kaskel the importance of non-HDL cholesterol reporting in lipid management. Dr. Jacobson describes additional lipid parameters that are emerging as valuable adjuncts to the standard panel, including measurements of apolipopprtoeins and LDL particle size and concentration. Specifically, Dr. Jacobson outlines the importance of non-HDL-C as a secondary goal of therapy, and the advantages of non-HDL measurements over traditional lipid parameter for the prediction of cardiovascular events. Most importantly, Dr. Jacobson provides the simple calculation for this measurement which is not yet reported on standard lipid panels, but is easily accessible from the information on these routine panels. Brought to you by:

Collectivistic statist turf war insanity King rejects govt's resignation, for now by Robert Wielaard http://www.washingtontimes.com/news/2008/jul/17/king-rejects-govts-resignation-for-now-1/ Governmental "officials" tear markets apart and extol self-sacrifical "public service" D.C. Arrests Residents For Missing Jury Service by Keith L. Alexander http://www.washingtonpost.com/wp-dyn/content/article/2008/07/13/AR2008071301798_pf.html Forced "justice" makes perfect sense, doesn't it; coercion is "cooperation" Jurors are essentially slaves of judges; jury nullification is illegal, sayeth "the law" The legal system benefits government and lawyers and screws the enslaved "customers" Once again, voting and jury nullification are not needed to achieve liberty; rather, people's independent mindset is Legislature approves bill banning trans fats by Samantha Sondag http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2008/07/15/MN0111OTUA.DTL The 'land of ban' scoffs at the nature of property rights; public pressure is voluntary; governmental pressure is coercive The most important thing in the world that needs protecting: Your right to choose a couple interesting scientific articles related to cardiovascular health: Lipoproteins and Atherosclerosis -- The Role of HDL Cholesterol, Lp(a), and LDL Particle Size (just google the article title and click from there, if you get the annoying sign-in page) http://www.medscape.com/viewarticle/439375 Measurement of LDL and HDL particle size does not improve CAD diagnosis http://www.lipidsonline.org/news/print.cfm?aid=6602 Genetic-testing start-ups asked to stop selling in Calif. by Stefanie Olsen http://news.cnet.com/8301-10784_3-9971383-7.html?hhTest=1 Perfect example of the regulatory State; following the money trail and areas of corporate convolution What a free market in medicine would be like: everything becomes more and more affordable Bush lifts executive ban on offshore oil drilling http://www.cnn.com/2008/POLITICS/07/14/bush.offshore/index.html Politics in midstream, once again, based on central planning; rather, all drilling areas should be privately owned and regulated--and thus be accountable here's a great blog post with lots of info: The Oil Pricing Squeeze Is On by David Theroux http://www.independent.org/blog/?p=140 Deadliest job in America: Working on cell phone towers http://tech.yahoo.com/blogs/null/97827 OSHA fascists to the rescue! Give me a break; say goodbye to common sense and productivity; workers know their work best; rational tort law All the most vile forms of tyranny come from the edict that "This is for your safety"--as if we should look to a coercive monopoly to protect us The guiding light for people in the free market: Use your own judgment, do things reasonable and prudent based on the circumstances, and don't follow authoritarian rules for their own sake Loss of personal control and belief in Higher Powers http://atheists.meetup.com/518/boards/view/viewthread?thread=5064714 Need for self-esteem and individual choice "But Who Will Build the Roads" Market Anarchy Explained http://www.newhampshirefreepress.com/NHFreePress/?q=node/166 The contradiction of government: Evil people controlling other purportedly evil people? Death By Government by R. Rummel http://tinyurl.com/rusyx The governmental employee modus operandi: passing the buck and shirking moral responsibility They Didn’t Attack Switzerland by Bill Walker http://www.lewrockwell.com/walker/walker32.html The whole "war on terror" is ill-gotten; US government only protects their own (and even that fails) Collectivistic thinking treats States as quasi-individuals; coercive government is the real problem, not a State that has an interventionist foreign policy bumper music "All You Fascists" by Billy Bragg And Wilcohttp://www.billybragg.co.uk/releases/albums/mermaid_avenueII/merII11.html to comment, please go to http://completeliberty.com/magazine/category/91697  

Dr. Cooper and Todd Whitthorne discuss the latest data on cholesterol. The discussion includes a brief review of how the body uses LDL cholesterol, and an explanation of why it's a bit of a misnomer that LDL cholesterol is the "bad? cholesterol. Raising HDL cholesterol, the “good? cholesterol through aerobic/cardiovascular conditioning is suggested. The question of whether lowering the LDL cholesterol with statin medications is an effective way to reduce death from cardiovascular disease is raised. Dr. Cooper recommends steps to reduce cholesterol naturally first, with statin medication as an option if natural methods don"t move the score enough. The cost and side effects of taking a statin are discussed. In a large study, 3 percent of the subjects taking the placebo (sugar pill) had heart attacks, while 2 percent had heart attacks while taking the statin. In terms of real numbers, the difference between the two groups was very small. Dr. Cooper talks about an article published in the September issue of The New England Journal of Medicine, “HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events.? There is disagreement in the medical community about whether statin medications are beneficial. “Do Cholesterol Drugs Do Any Good?? BusinessWeek cover story, Jan. 17, 2008, is discussed. Dr. Cooper's book Controlling Cholesterol the Natural Way  is a resource for people who want to control their cholesterol without drugs. The SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) findings are reviewed. Dr. Beatrice A. Golomb's statin effects study is reviewed .  Dr. Golomb has been actively researching statin medications and their risk-benefit balance, including possible side effects. 

Background: Toll-like receptor 4 (TLR4), the signaling receptor for lipopolysaccharides, is an important member of the innate immunity system. Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes. Methods: A case-cohort study was conducted in initially healthy, middle-aged subjects from the MONICA/KORA Augsburg studies including 498 individuals with incident type 2 diabetes and 1,569 noncases. Seven SNPs were systematically selected in the TLR4 gene and haplotypes were reconstructed. Results: The effect of TLR4 SNPs on incident type 2 diabetes was modified by the ratio of total cholesterol to high- density lipoprotein cholesterol (TC/HDL-C). In men, four out of seven TLR4 variants showed significant interaction with TC/HDL-C after correction for multiple testing (p < 0.01). The influence of the minor alleles of those variants on the incidence of type 2 diabetes was observed particularly for male patients with high values of TC/HDL-C. Consistent with these findings, haplotype-based analyses also revealed that the effect of two haplotypes on incident type 2 diabetes was modified by TC/HDL-C in men (p < 10(-3)). However, none of the investigated variants or haplotypes was associated with type 2 diabetes in main effect models without assessment of effect modifications. Conclusion: We conclude that minor alleles of several TLR4 variants, although not directly associated with type 2 diabetes might increase the risk for type 2 diabetes in subjects with high TC/HDL-C. Additionally, our results confirm previous studies reporting sex-related dissimilarities in the development of type 2 diabetes.

Guest: Robert S. Rosenson, MD Host: Matthew J. Sorrentino, MD, FACC, FASH Dr. Robert Rosenson, Director of Lipoprotein Disorders at the University of Michigan, will review the importance of HDL cholesterol and how we can try to raise the HDL levels for cardiac protection.

Guest: Robert S. Rosenson, MD Host: Matthew J. Sorrentino, MD, FACC, FASH Will novel HDL cholesterol therapies reduce cardiovascular risk? Dr. Robert Rosenson will discuss the hope for CETP inhibitors and HDL mimetics to modify HDL cholesterol and coronary heart disease risk.

Pfizer pharmaceutical company was on the brink of releasing a new medication that would significantly increase HDL, the healthy cholesterol. Suddenly they stopped the research and abandoned the product - we'll discuss what happened. Dr. Cooper shares ways we can increase HDL cholesterol without medication. And, more research confirms that keeping your heart healthy is also a great way to keep your brain healthy. Dr. Cooper takes calls.