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In this episode of Wash Talk, host Brian Ankney talks to Cameron Ray of Sparkle Express Car Wash and Noel Peña of Digital Recognition Network (DRN) about data-driven carwash marketing. The conversation explores how Sparkle Express uses DRN's license plate recognition and vehicle data to target potential customers based on behavior, such as driving frequency and vehicle type, rather than just proximity. This approach allows for precise outreach, replacing broad tactics like direct mail and geofencing. A recent campaign reached 330,000 qualified prospects and saw an 8% redemption rate, with 2% converting to monthly memberships. The discussion highlights how behavior-based targeting drives higher ROI and long-term customer value in today's carwash market.
Join us for the second of a two part conversation with Pastor Steve McVey, the founder of the Dirt Roads Network. In the first episode Pastor Steve talked about revitalization through the lens of his time as pastor in Lamont, Kansas. This week, we will dive into the resource that is the Dirt Roads Network and talk about the future of the rural church. You can find more info on the DRN at www.dirtroadsnetwork.com As always, if you would like to connect with the show for encouragement, or to give ideas or feedback, reach out to our host Joe Epley at joseph.g.epley@gmail.com
DRN president Jeremiah Wheeler appeared on the Auto Remarketing Podcast this week to continue the intensifying dialogue about license plate recognition technology. Wheeler elaborated about the company's response to assertions made by the American Recovery Association and what he hopes the future holds for repossession agents, finance companies, forwarders and other recovery industry service providers.
Join us for a two part conversation with Pastor Steve McVey, the founder of the Dirt Roads Network. In this first episode Pastor Steve talks about revitalization through the lens of his time as pastor in Lamont, Kansas. His story is a great encouragement for all those facing difficult church contexts. Next week, we will dive into the resource that is the Dirt Roads Network and talk about the future of the rural church. You can find more info on the DRN at www.dirtroadsnetwork.com As always, if you would like to connect with the show for encouragement, or to give ideas or feedback, reach out to our host Joe Epley at joseph.g.epley@gmail.com
TRENDSPIDER BLACK FRIDAY SALE - SAVE UP TO 71% - HUGE - DO NOT MISS THIS LIMITED TIME OFFER 1. Bitcoin hit $90k and I bought $MSTX - a 2x Leveraged ETF on $MSTR - BULL RUN 2. How to spot weakness - I sold $DRN 3. $AMZN - Bezzo's is selling - u should buy 4. $NVDA - full look 5. Netflix 6. $ARKK strategy - LOVE IT 7. $TSLA - buy now? 8. $SMCI - GET OUT 9. Earnings $SPOT $RKLB $CYBR and more GET THE SEEKING ALPHA BUNLDE AND SAVE OVER $150
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Jeremiah Wheeler, president of DRN, MVTRAC and now SCM, takes us on a journey recapping the evolution of license plate recognition technology, how it's boosted repossessions and recoveries, as well as how the data collected is helping other automotive marketing efforts. Plus, Wheeler shares an update about the company, its latest acquisition and most difficult challenge overcome so far this year.
Počítače vládnou světu a burzám jakbysmet. Skvělým důkazem je český podnikatel Petr Zahradník a jeho společnost Qminers, která se věnuje takzvanému algoritmickému obchodování. Sice je širší veřejnost moc nezná, jenže jestli na někoho platí, že jede takříkajíc bomby, jsou to oni: v roce 2023 utržili 800 milionů a v čistém vydělali 400 milionů. Z fascinujícího Zahradníkova života je to ale jen jeden z dílků mozaiky: talent na matematiku zdědil po tatínkovi, profesorovi na Matfyzu, jeho strýček je miliardář Petr Němec, který v centru Prahy postavil unikátní DRN, jeho prarodiči jsou světoznámí skláři Jaroslava Brychtová a Stanislav Libenský.Kdo je jeho byznysový vzor? Jak uvažuje o investování? Co mu dala rodina? Jak vnímá umění a jeho odkaz? Proč podporuje učitele matematiky? O tom všem byla řeč v našem podcastu Money Maker. 00:00:00 Začínáme 00:04:15 Inspirativní rodinné zázemí Petra Zahradníka 00:09:15 Matfyz a nedostatek kvalitních příležitostí pro jeho absolventy 00:13:15 „V RSJ mě odmítli“ Založení vlastního byznysu 00:20:48 Co je algoritmický trading? 00:34:44 Qminers jako firma pro lidi, kteří chtějí potrápit svou hlavu 00:44:30 Peníze nejsou „dirty“. Jak vysvětlit přidanou hodnotu tradingu? 00:47:11 Investice do konkurenčních byznysů 00:57:33 Proč podporuje paliativní medicínu, péči o krajinu a výuku matematiky 01:04:30 Architektura a odkaz prarodičů
In this episode, hear from Joey Coleman, award-winning speaker and New York Times bestselling author, as he delves into the importance of customer experience in the car wash industry. For more than twenty years, Joey has helped organizations retain their best customers and employees - turning them into raving fans via his entertaining and actionable keynotes, workshops, and consulting projects. In this engaging episode, you'll learn why customer service is considered the last great differentiator in driving success for your car wash location. Learn how to create a unique and distinct experience that your customers will love. You'll also hear Coleman explain why employee experience is crucial for driving the success of your business. This episode is sponsored by DRN, a car wash industry leader in capturing drive by traffic and fueling new leads.
Drn, báč, babčák nebo láta, to jsou všechno názvy pro pokrm, který je u nás znám především jako bramborák. Jak ho připravovaly naše babičky, poví Jaroslav Hoření a Vladimíra Jakouběová.
Step 24 years into the future with Andrew and his android podcasting partner Presley as they discuss this futuristic police procedural.All our Links: https://linktr.ee/seasononepodSeason Spoiler Synopsis: Almost Human was a 2013 mystery crime procedural that takes place in the year 2048. The show focused on Detective John Kennex (Karl Urban) as he returns to the police force several months after a raid gone bad having been the only survivor and losing one of his legs. At this point in the future, technology has advanced far enough to where every detective has an android partner know as MX's. John, upon returning to the force, wants a human partner as it was good enough for his partner and, in trying to do so, throws his MX out of his car onto the highway. His replacement is a DRN named Dorian (Michael Ealy), who had been decommissioned along with the rest of the DRNs when they were believed their emotions made them unstable and harmful. Unlike the MXs, who are very stereotypical, vacant, and unemotional robots, the DRNs and Dorian have emotions, look more human, and still possess the strength, intelligence, and combat skills of the other MXs. Over the course of the series, John and Dorian solve a variety of crimes all usually related to the group that lead to the botched raid John had conducted known as Insindicate. The series ends with a revelation that Dorian somehow contains organic human memories of childhood and the two having now become friends and good partners.
I bought more $PXD so subscribe to me on Savvy Trader to get those alerts. I also still love $NFLX at these prices and $SMCI and $NVDA should continue to move. I think it was a great episode today for a Friday. Get my algo and a special offer on Trendspider - https://trendspider.com?_go=gary93 Get $50 off a year of Seeking Alpha. https://www.sahg6dtr.com/2L9M597/R74QP/ TESLA referral -Use my referral link to buy a Tesla and get up to $500 off and 3 months of Full Self-Driving Capability. https://www.tesla.com/referral/gary82526 Social Links and more - https://linktr.ee/dailystockpick FREE NEWSLETTER WITH CHARTS - subscribe at dailystockpick.substack.com SPONSORED BY VISIBLE - Check out this page: https://www.visible.com/get/?3P8FJPM $20 off your first month - only $5 for the first month Sign up for Webull and get free stocks like I did - https://a.webull.com/gGlte9iTQnfaDYFa4S NOTES The jobs report - CRAZY STRONG - this is REALLY bad meaning we may see the Fed raise in Nov - 3.8% unemployment is one of the lowest rates 330k new jobs in Sept and Aug was adjusted to 270k from 190k - it's an absolute blow out This means we are NOT seeing a softness in the job market like the fed has been saying which would indicate the Fed has to raise Remember - we hit bottom when good news is good news - this is good news is bad news VIX is at 19 so there's no panic selling - it's just no buyers Bonds went CRAZY - 2 to 10 inversion shrunk to it's lowest rate since it inverted - the 10 went from 4.7% to 4.8% which is a BIG move We initially discussed traders and investors identifying a confluence of technical “levels” and indicators in the $410-$420 range of the S&P 500 ETF $SPY. As we pointed out last time, not only is the market's May breakout level near 420 but so is the volume-weighted average price from its 2022 highs and 2022 lows. And with buyers stepping in over the last few days, chatter is beginning to build that this area could stem the recent 10% pullback $spy sell rating and the magnificent 7 $PFIE - Energy name from Seeking Alpha I found that Christian is holing at $1.14 - is it going back to $3 or to $1? I still love $SMCI and notice how $nvda rides that 200 day $RIVN - this could be a time to buy for a trade - not to hold $boil $sco $pxd is up on more rumors of $xom buying them again $tsla cut prices again by $2k I still like $pypl $nvda - OpenAI may make their own chips $META - new ways that Meta may be able to generate revenue from AI $NFLX password sharing unlocks value - $500 price target SCANS $JNJ $UNH $LLY $DIS $VOO $DRN $DPST $XLV $XLRE - with XLRE and DRN having a MacD cross up - might be a good time for Real Estate to bounce again $VFS $IBM $MRK $MA $SO $BLK $USB - Brian wanted me to look in to this so I will Vanguard Low Cost ETFs that are bullish $VTI $VOO $VOT $VNQ --- Send in a voice message: https://podcasters.spotify.com/pod/show/dailystockpick/message
Follow along with all my trades and journal your own here - https://savvytrader.com/Dailystockpick/2023-trading-portfolio I love Webull - Sign up here and get FREE STOCKS $GOOG and $MSFT earnings - wait for good prices - $META I like under $300 - $TSLA - I may have missed - but have patience. I'll expand some charts in the newsletter so be sure to subscribe. FREE NEWSLETTER WITH CHARTS - subscribe at dailystockpick.substack.com SPONSORED BY VISIBLE - Check out this page: https://www.visible.com/get/?3MFGCRG $20 off your first month - only $5 for the first month Use code DSP25 for 25% off Trendspider's platform - https://trendspider.com/?_go=gary93 Sign up for Webull and get free stocks like I did - https://a.webull.com/yNyte9iTQnfaDYFHdv Social Links and more - https://linktr.ee/dailystockpick NOTES Fed meeting today and decision tomorrow Overall putting money in here - does risk justify reward? Meaning there hasn't been a pullback of the great 8 … there is resistance at $460 on spy Tom Lee says def new highs - maybe $500 Scalping strategy https://youtu.be/XBcMiYK7qYY Rule 1 - trade above the 200 day ema (I use sma) Rule 2 - rsi divergence - put a line at 50 and trade above the line (not necessary but nice tk have) Rule 3 - look for an engulfing candle - opens at lower than the previous red candle and the close is above the high of the previous red candle Enter only after the green candle closes in rule 3 Stop loss 2 times the profit $o and $fsm for Brandon from fb $meta and $msft earnings $DRN buy at $10.45 SCANS $BA $DIS $CHRD $DRN $VNQ $XLRE $PDD $NIO $KWEB $XPEV $SABR $BABA $HON $JD $TMUS $GD $AMT --- Support this podcast: https://podcasters.spotify.com/pod/show/dailystockpick/support
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.21.550014v1?rss=1 Authors: Boi, L., Johansson, Y., Tonini, R., Moratalla, R., Fisone, G., Silberberg, G. Abstract: Parkinson's disease (PD) is characterized by motor impairments caused by degeneration of dopamine neurons in the substantia nigra pars compacta. In addition to these symptoms, PD patients often suffer from non-motor co-morbidities including sleep and psychiatric disturbances, which are thought to depend on concomitant alterations of serotonergic and noradrenergic transmission. A primary locus of serotonergic neurons is the dorsal raphe nucleus (DRN), providing brain-wide serotonergic input. Here, we identified electrophysiological and morphological parameters to classify serotonergic and dopaminergic neurons in the murine DRN under control conditions and following striatal injection of the catecholamine toxin, 6-hydroxydopamine (6-OHDA). Electrical and morphological properties of both neuronal populations were altered by 6-OHDA. In serotonergic neurons, most changes were reversed when 6-OHDA was injected in combination with desipramine, a noradrenaline reuptake inhibitor, protecting the noradrenergic terminals. Our results show that the depletion of both noradrenaline and dopamine in the 6-OHDA mouse model causes changes in the DRN neural circuitry. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.04.539464v1?rss=1 Authors: Al-Kachak, A., Fulton, S. L., Farrelly, L. A., Lepack, A. E., Bastle, R. M., Kong, L., Cathomas, F., Newman, E. L., Menard, C., Ramakrishnan, A., Chan, J. C., Safovich, P., Lyu, Y., Covington, H. E., Shen, L., Gleason, K., Tamminga, C. A., Russo, S. J., Maze, I. Abstract: Background: Major depressive disorder (MDD) is a debilitating illness that affects millions of individuals worldwide. While chronic stress increases incidence levels of MDD, stress-mediated disruptions in brain function that precipitate the disorder remain elusive. Serotonin-associated antidepressants (ADs) remain the first line of therapy for many with MDD, yet low remission rates and delays between treatment and symptomatic alleviation have prompted skepticism regarding precise roles for serotonin in the precipitation of MDD. Our group recently demonstrated that serotonin epigenetically modifies histone proteins (H3K4me3Q5ser) to regulate transcriptional permissiveness in brain. However, this phenomenon has not yet been explored following stress and/or AD exposures. Methods: Here, we employed a combination of genome-wide (ChIP-seq, RNA-seq) and western blotting analyses in dorsal raphe nucleus (DRN) of male and female mice exposed to chronic social defeat stress to examine the impact of stress exposures on H3K4me3Q5ser dynamics in DRN, as well as associations between the mark and stress-induced gene expression. Stress-induced regulation of H3K4me3Q5ser levels were also assessed in the context of AD exposures, and viral-mediated gene therapy was employed to manipulate H3K4me3Q5ser levels to examine the impact of reducing the mark in DRN on stress-associated gene expression and behavior. Results: We found that H3K4me3Q5ser plays important roles in stress-mediated transcriptional plasticity in DRN. Mice exposed to chronic stress displayed dysregulated dynamics of H3K4me3Q5ser in DRN, and viral-mediated attenuation of these dynamics rescued stress-mediated gene expression programs and behavior. Conclusions: These findings establish a neurotransmission-independent role for serotonin in stress-associated transcriptional and behavioral plasticity in DRN. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.538086v1?rss=1 Authors: Maxwell, N. D., Smiley, C. E., Sadek, A. T., Loyo-Rosado, F. Z., Giles, D. C., Macht, V. A., Woodruff, J. L., Taylor, D. L., Wilson, S. P., Fadel, J. R., Reagan, L. P., Grillo, C. A. Abstract: Leptin is a homeostatic regulatory element that signals the presence of energy stores -in the form of adipocytes- which ultimately reduces food intake and increases energy expenditure. Similarly, serotonin (5-HT), a signaling molecule found in both the central and peripheral nervous systems, also regulates food intake. Here we use a combination of pharmacological manipulations, optogenetics, retrograde tracing, and in situ hybridization, combined with behavioral endpoints to physiologically and anatomically identify a novel leptin-mediated pathway between 5-HT neurons in the dorsal raphe nucleus (DRN) and hypothalamic arcuate nucleus (ARC) that controls food intake. In this study, we show that microinjecting leptin directly into the DRN reduces food intake in male Sprague-Dawley rats. This effect is mediated by leptin-receptor expressing neurons in the DRN as selective optogenetic activation of these neurons at either their ARC terminals or DRN cell bodies also reduces food intake. Anatomically, we identified a unique population of serotonergic raphe neurons expressing leptin receptors that send projections to the ARC. Finally, by utilizing in vivo microdialysis and high-performance liquid chromatography, we show that leptin administration to the DRN increases 5-HT efflux into the ARC. Overall, this study identifies a novel circuit for leptin-mediated control of food intake through a DRN-ARC pathway, utilizing 5-HT as a mechanism to control feeding behavior. Characterization of this new pathway creates opportunities for understanding how the brain controls eating behavior, as well as opens alternative routes for the treatment of eating disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.18.529065v1?rss=1 Authors: Ng, A. J., Vincelette, L. K., Li, J., Brady, B. H., Christianson, J. P. Abstract: Social interaction allows for the transfer of affective states among individuals, and the behaviors and expressions associated with pain and fear can evoke anxiety-like states in observers which shape subsequent social interactions. We hypothesized that social reactions to stressed individuals engage the serotonergic dorsal raphe nucleus (DRN) which promotes anxiety-like behavior via postsynaptic action of serotonin at serotonin 2C (5-HT2C) receptors in the forebrain. First, we inhibited the DRN by administering an agonist (8-OH-DPAT, 1ug in 0.5uL) for the inhibitory 5-HT1A autoreceptors which silences 5-HT neuronal activity via G-protein coupled inward rectifying potassium channels. 8-OH-DPAT prevented the approach and avoidance, respectively, of stressed juvenile (PN30) or stressed adult (PN50) conspecifics in the social affective preference (SAP) test in rats. Similarly, systemic administration of a 5-HT2C receptor antagonist (SB242084, 1mg/kg, i.p.) prevented approach and avoidance of stressed juvenile or adult conspecifics, respectively. Seeking a locus of 5-HT2C action, we considered the posterior insular cortex which is critical for social affective behaviors and rich with 5-HT2C receptors. SB242084 administered directly into the insular cortex (5uM bilaterally in 0.5uL) interfered with the typical approach and avoidance behaviors observed in the SAP test. Finally, using fluorescent in situ hybridization, we found that 5-HT2C receptor mRNA (htr2c) is primarily colocalized with mRNA associated with excitatory glutamatergic neurons (vglut1) in the posterior insula. Importantly, the results of these treatments were the same in male and female rats. These data suggest that interactions with stressed others require the serotonergic DRN and that serotonin modulates social affective decision-making via action at insular 5-HT2C receptors. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
The very first and most frequent guest on the Auto Remarketing Podcast appeared again during the 2023 Vehicle Finance Conference hosted by the American Financial Services Association in Dallas. Jeremiah Wheeler, president of DRN and MVTRAC, offered an update about consumer migratory patterns and how they're influencing vehicle repossessions.
$SPY is going to be in a range but it's not giving a clear signal. Earnings start this week so if you want to wait, be patient. If you want to buy stocks - buy stocks that are cheap, make good products or services and have solid cash flow. Use code DSP25 for 25% off Trendspider's platform - https://trendspider.com/?_go=gary93 Please use this link as I do get a commission when you sign up, but it's the program I use my algorithm in and I'll give you access to the algorithm if you sign up through this link. I will also give you watch lists and my custom scans that I use in the podcast every day. Sign up for Webull and get free stocks like I did - WEBULL LINK Support the podcast - HERE Social Links and more - https://linktr.ee/dailystockpick 52 week highs $MRK $CB $TRV $LVS $PCG 52 week lows $AAPL $AMZN $TSLA $DIS $CME $Meta - very cheap stock and it's been a meaningful $M warns about q4 numbers …. Any move towards $20 is good Look at $spy Check $mrna insta ? Any chance you could talk about volume on the pod next week? I have volume by price added to trendspider, but that doesn't show if it's net negative or positive right? Talk about why bond funds are bad vs bonds - bond funds hold current and constantly get new bonds which may bring the price of the assets down vs bonds held in a lowering rate environment the asset goes up $Fcx - look at materials Duke university professor says the inversion of thr yield curve is a false signal and his model shows no recession My weekly stock pick - $cat - Last week, my stock pick increased by 4.0%, bringing my performance in 2023 to a positive 4% $Lulu $AAPL - we will cover the gap Questions about day trading vs. swing trading $VZ and $T SCANS $HD - rather see you in $DRN at around $10 $INTU - $PG $AEP $DUK $MRO - best energy in a long list - if you have Trendspider and want my scanner - let me know - but there were energy names galore --- Support this podcast: https://anchor.fm/dailystockpick/support
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.14.516867v1?rss=1 Authors: Barde, S., Aguila, J., Zhong, W., Solarz, A., Mei, I., Prud'homme, J., Palkovits, M., Turecki, G., Mulder, J., Uhlen, M., Nagy, C., Mechawar, N., Hedlund, E., Hokfelt, T. Abstract: BACKGROUND: Major depressive disorder (MDD) is a serious disease and a burden to patients, families and society. Rodent experiments and human studies suggest that several neuropeptide systems, including substance P(SP)/tachykinin, neuropeptide Y(NPY) and their G protein-coupled receptors are involved in mood regulation.METHODS: We assessed the transcript levels (qPCR) of SP/tachykinin and NPY systems in five regions from postmortem brains of male and female depressed subjects who committed suicide (DSS) and controls: dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), the dorsal raphe nucleus (DRN), locus coeruleus (LC) and medullary raphe nuclei (MRN). We also analysed human LC neurons isolated using LCM with Smart-seq2 RNA sequencing. RESULTS: Transcripts for all nine members were detected in male and female controls with marked regional variations of the raw CT values and with the highest levels for several tachykinin and tachykinin receptor transcripts in the DRN and for NPY and NPYR transcripts in the PFC regions. Significant sex differences for controls were recorded only in the DRN (NPYR2 greater than in females) and LC (TAC3 and NPY greater than in females). Elevated expression in DSS was recorded in (i) DLPFC for SP, TAC and TAC3 in females, SP in males, and NPYR1 in both sexes; and (ii) LC for all tachykinin family transcripts in females, SP, TACR1 and TACR3 in males, NPY in both sexes, and NPYR1 in males. CONCLUSIONS: The selective perturbation of neuropeptide systems in MDD patients may assist in the search for novel treatment strategies for subjects afflicted by this grave disorder. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.22.517403v1?rss=1 Authors: Pierson, S., Fiock, K., Wang, R., Balasubramanian, N., Khan, K., Betters, R., Lee, G., Hefti, M. M., Marcinkiewcz, C. A. Abstract: Protein aggregation in brainstem nuclei is thought to occur in the early stages of Alzheimer's disease (AD), but its specific role in driving prodromal symptoms and disease progression is largely unknown. The dorsal raphe nucleus (DRN) contains a large population of serotonin (5-hydroxytryptamine; 5-HT) neurons that regulate mood, reward-related behavior, and sleep, all of which are disrupted in AD. We report here that tau pathology is present in the DRN of cognitively intact individuals 54-80 years of age, whereas synuclein and TDP-43 are relatively absent. Almost all AD cases had tau pathology in the DRN, whereas only a subset contained TDP-43 or synuclein, but not both. Mice overexpressing human P301L-tau in the DRN also exhibited depressive-like behaviors and hyperactivity without any deficits in spatial memory. There was a negative correlation between the density of Tph2-expressing neurons and phospho-tau (ptau) optical density in P301L-tauDRN mice, although mean Tph2 expression did not differ significantly from the controls. 5-HT neurons were hyperexcitable in P301L-tauDRN mice, and there was an increase in the amplitude of excitatory post-synaptic currents (EPSCs) which is suggestive of increased glutamatergic transmission. Astrocytic density was also elevated in the DRN and accompanied by an increase in GFAP expression, as well as changes in Htr2a, Htr2c, and Htr3a gene expression. Additionally, tau pathology was detected in axonal processes in the thalamus, hypothalamus, amygdala, and caudate putamen, suggesting that tau may spread in an anterograde manner to regions outside the DRN. Together, these results suggest that tau pathology accumulates in the DRN in a subset of individuals over 50 years and may lead to prodromal AD symptoms, 5-HT neuronal dysfunction, and activation of local astrocytes. The presence of tau pathology in the DRN combined with psychiatric assessments for depression may be a useful screening tool for individuals at risk for AD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.12.511924v1?rss=1 Authors: Yu, Q., Gu, L., Lian, X., Wang, Y., Xu, Q., Ma, H., Liu, L., Shao, W., GU, J., Shen, Y., Chen, L., Zhang, H. Abstract: Although some advancements concerning the arousal involved in mediating the delayed emergency from general anesthesia, which will lead to the serious complications, had been made, the role by arousal in modulating in delayed emergency still remains to be unclear. In our models, based on our previous working that activation of the 5-Hydroxytryptamine (5-HT) neurons in the dorsal raphe nucleus (DRN) by optogenetics can significantly reduce the emergency time by activating arousal pathway, we further test whether the serotonergic neural circuit between the DRN and the basolateral amygdala (BLA) is implicated in modulating the arousal from the sevoflurane anesthesia and the emergency time of sevoflurane anesthesia by the pharmacological, optogenetics and fiber photometry. Our findings showed that whether the serotonergic neural circuit between the DRN and the basolateral amygdala (BLA) plays a key role in modulating the arousal from the sevoflurane anesthesia and the emergency time of sevoflurane anesthesia. Based on the serotonergic neural circuit, the 5-HT 1 A receptor is of great significance to mediate the arousal and the emergency time of the sevoflurane anesthesia. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.05.506646v1?rss=1 Authors: Torres Irizarry, V. C., Feng, B., Yang, X., Patel, N., Schaul, S., Ibrahimi, L., Ye, H., Luo, P., Carrillo Saenz, L., Lai, P., Kota, M., Dixit, D., Wang, C., Lasek, A. W., He, Y., Xu, P. Abstract: The ovarian hormone estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms for estrogen-induced binge drinking are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We used the drinking in the dark (DID) behavioral test in mice to mimic binge drinking in humans. We found that female mice drank more alcohol than male mice in chronic DID tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor alpha (ERalpha) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling in binge alcohol drinking. In supporting this view, 5-HTDRN neurons from naive male mice had lower baseline neuronal firing activity but higher sensitivity to alcohol-induced excitation compared to 5-HTDRN neurons from naive female mice. Notably, this higher sensitivity was blunted by 17bata-estradiol treatment in males, indicating an estrogen-dependent mechanism. We further showed that both ERalpha and ERbeta are expressed in 5-HTDRN neurons, whereas ERalpha agonist propyl pyrazole triol (PPT) depolarizes 5-HTDRN neurons and ERbeta agonist diarylpropionitrile (DPN) hyperpolarizes 5-HTDRN neurons. Notably, both PPT and DPN treatments blocked the stimulatory effects of alcohol on 5-HTDRN neurons in males, despite the fact that they have antagonistic effects on the activity dynamics of 5-HTDRN neurons. These results suggest that the inhibitory effects of ERs on ethanol-induced burst firing of 5-HTDRN neurons may contribute to higher levels of binge drinking in females. Consistently, chemogenetic activation of ERalpha- or ERbeta-expressing neurons in the DRN reduced binge alcohol drinking. These results support a model in which estrogens act on ERalpha/beta to prevent alcohol-induced activation of 5-HTDRN neurons, which in return leads to higher binge alcohol drinking. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.31.506056v1?rss=1 Authors: Lynn, M. B., Geddes, S., Chahrour, M., Maille, S., Harkin, E., Harvey-Girard, E., Haj-Dahmane, S., Naud, R. B., Beique, J.-C. Abstract: Serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) receive a diverse constellation of long-range synaptic inputs, yet unifying principles of local circuitry and its dynamics are largely unknown - a crucial component of understanding how 5-HT output controls behavior. Here, we developed a formalism bridging optogenetic, electrophysiological, computational and behavioral strategies to reveal how the dynamics of local circuitry in DRN control the expression of reward associations. Using long-range input from lateral habenula (LHb) to interrogate functional DRN circuitry, we uncover 5-HT1A receptor-mediated local recurrent connections between 5-HT neurons, refuting classical theories of autoinhibition by 5-HT1A receptors. These inhibitory 5-HT connections were slow, stochastic, strongly facilitating, and gated spike output of 5-HT neurons. Targeted physiology and modeling approaches revealed that these functional connectivity features collectively support the emergence of a paradoxical excitation-driven inhibition in response to high frequency LHb activation, and of a winner-take-all computation over protracted timescales. In vivo, we found that optogenetic activation of LHb inputs to DRN transiently disrupted expression of a reward-conditioned response in an auditory conditioning task. In accordance with quantitative model predictions, this disruption occurred exclusively at the conjunction of high frequency LHb activation and high predicted reward value, and was not due to a modulation of the underlying reward association. Thus, we propose that recurrent dynamics in the DRN support a contextual value computation, where stable learned associations are integrated with dynamic environmental inputs to support sharp behavioral state transitions in changing environments. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
第41期脑科学新闻 | 孤独的果蝇睡得少吃得多，年轻鼠的脑脊液改善老年鼠的记忆能力导读：海德，陶火，Li Xun责编：呆苏克主播：小胡背景音乐：夜的钢琴曲五_石进Nature | 孤独的果蝇，睡眠更少，吃得更多自新冠疫情爆发以来，“隔离”就成了我们生活中“常客”。与隔离一同出现的，除了焦躁不安的情绪、人际关系的疏离，往往还有与日俱增的体重和日益减少的睡眠。事实上，这种现象不仅仅出现在人类身上，小小的果蝇也是如此。近日，来自洛克菲勒大学的研究人员使用定量行为分析和生物信息学分析来研究了果蝇在短期或长期社会隔离后大脑状态的差异，发现短期社会隔离（与群体分隔1天或3天）并不会导致果蝇睡眠不足，而长期社会隔离（与群体分隔5天或7天）则会显著降低果蝇睡眠时间。此外，缺乏社交活动的果蝇大脑状态与其饥饿时非常相似，表明长期社会隔离可能会改变代谢相关基因的表达，从而引发“饥饿”。研究人员在进一步研究中发现P2神经元对该效应有重要作用。沉默果蝇的P2神经元可显著降低长期社会隔离对果蝇的影响，而激活短期社会隔离组果蝇的P2神经元则会导致睡眠不足和更多的食物摄入。这些结果表明，P2神经元参与了调节社会隔离效应的回路，并可能发挥类似“计时器”的作用，监测隔离持续的时长。这一研究揭示了果蝇和人类在面对长期的“社会隔离”时具有许多相似之处，并建立起了一个可以用于研究社会隔离对大脑、心理的影响的模型，同时给予了我们更多利用低等生物来模拟和研究人类心理健康现象的灵感。（导读：海德）文章来源：https://www.nature.com/articles/s41586-021-03837-0图片来源：https://static01.nyt.com/images/2020/03/24/science/24BRODYISOLATION/24BRODYISOLATION-superJumbo.jpgNature | 年轻鼠的脑脊液改善老年鼠的记忆能力在缓慢老去的过程中，人的记忆力往往会越来越差，且目前尚无能够有效改善或提高记忆力的方法。在人均寿命日益延长的今天，减缓大脑衰老或设法保持大脑的认知、记忆功能成为了一个亟待解决的问题。近日，来自斯坦福大学的Tony Wyss-Coray团队尝试将年轻小鼠（10周龄）的脑脊液灌注进老年小鼠（18月龄）的脑中，发现这一举措可以显著改善老年小鼠在恐惧条件反射任务中的记忆表现。通过对海马体进行转录组分析，研究人员发现少突胶质细胞可能是介导这一变化的关键细胞类群，并在体外和体内分别证实了年轻的脑脊液能够促进少突胶质细胞祖细胞的增殖、分化。研究人员随后用SLAMseq技术对新生成的mRNA进行标记，发现了受年轻脑脊液影响最大的“头号种子”——血清反应因子。对脑脊液中潜在的血清反应因子激活剂进行筛选，研究人员进一步确定了灌注成纤维细胞生长因子17 (Fgf17)能够诱导老年小鼠的少突胶质细胞祖细胞增殖并巩固长期记忆，而阻断Fgf17则会损害年轻小鼠的认知功能。利用年轻个体的身体成分“逆转”衰老过程的研究由来已久，但其背后的机制始终难寻。这一研究揭示了年轻的脑脊液中发挥作用的关键因子——Fgf17，厘清了“返老还童”这一神奇生理过程背后的生物学机制，也为治疗方法和药物的研发提供了新的可能。此外，这篇文章还证明了通过脑脊液给药方式治疗痴呆的可行性，对当今人口老龄化问题愈发严重的人类社会大有裨益。（导读：海德）文章来源：https://www.nature.com/articles/s41586-022-04722-0.pdf?origin=ppub图片来源：https://posturepractice.com/wp-content/uploads/2015/11/aging-memory-declin.jpgMolecular Psychiatry｜调节抑郁样行为的新环路：从内嗅皮层到次级视觉皮层根据世卫组织最新报告，抑郁症已成为人类致残的首要原因，全球罹患抑郁症的人群超2.8亿。但抑郁障碍病因复杂，相关机制研究和治疗手段仍十分有限。由于抑郁症涉及多个脑区，其被视作一种“神经环路疾病”（circuitopathies）。今年四月，清华大学郭增才课题组在线发表在《分子神经病学》（Molecular Psychiatry）上的一篇文章首次揭示了一条从内嗅皮层到次级视觉皮层内侧区的神经环路在抑郁症中具有双向调节作用。研究发现，在具有抑郁样表型的慢性社会挫败应激（CSDS）小鼠模型上，其内嗅皮层Va亚层神经活性降低。通过化学遗传和光遗传学方法，研究组发现抑制Ent→V2M通路可以诱发健康小鼠和加重应激小鼠抑郁样表型，而激活该通路则可以快速缓解抑郁样表型。该通路的作用机制与驱动小鼠转向抗抑郁状态相关。这为临床抑郁症的治疗提供了潜在靶点，特别是非侵入性刺激治疗，如经颅磁刺激、经颅直流电刺激等。（导读：陶火）文章链接：https://www.nature.com/articles/s41380-022-01540-8图片链接：https://pixabay.com/vectors/mental-therapy-counseling-people-6841357/?downloadNature Neuroscience | 5-羟色胺与中脑多巴胺在厌食症的作用在以瘦为美的时代，很多人都想拥有纤细的身材。但有一类患者，却因“瘦”而饱受折磨。厌食症（anorexia, AN）患者身形极度嶙峋，由于长期不能正常进食，他们严重营养不足，并且饱受精神折磨，痛苦不堪。近日，发表在Nature Neuroscience上的一篇文章研究了厌食症相关的分子机制。研究人员发现高浓度的多巴胺会增高中缝背核（dorsal raphe nucleus, DRN）5-羟色胺能神经元的放电频率与静息膜电位，而低浓度的多巴胺则产生相反效果。此外，腹侧被盖区（ventral tegmental area, VTA）的多巴胺能神经元可以投射到DRN，并调节其中的5-羟色胺能神经元。在将ChR2光敏感通道蛋白注入VTA的多巴胺能神经元时，低频（2Hz）蓝光会抑制DRN中5-羟色胺能神经元并增加小鼠对于食物的摄入（此过程可以被多巴胺受体D2拮抗剂阻止），而高频（20Hz）蓝光会激活DRN中5-羟色胺能神经元并抑制小鼠对于食物的摄入（此过程可以被多巴胺受体D1拮抗剂阻止）。在活动型厌食症（activity-based anorexia, ABA）小鼠模型中，激活的多巴胺能神经元激活DRN的5-羟色胺能神经元，这一过程依赖于多巴胺受体D1而非多巴胺受体D2。本研究提出了厌食症可能的生理机制，可能会为未来的临床治疗提供依据。（导读：Li Xun）文章链接：https://www.nature.com/articles/s41593-022-01062-0图片链接：https://cn.bing.com/images/search?q=%e5%8e%8c%e9%a3%9f%e7%97%87&form=HDRSC2&first=1&tsc=ImageHoverTitleNature Neuroscience | 青春期抑制丘脑活动对成年期前额叶的影响神经系统在青春期时可塑性增强，此时，外界刺激可能会对神经系统造成长久的影响。此外，精神分裂症与人脑前额叶（PFC）功能异常相关。那么，青春期其他脑区的异常会影响到成年期PFC的功能吗？来自哥伦比亚大学的研究团队探索了这一问题，研究者发现，在小鼠青春期而非成年期抑制丘脑，成年后小鼠的与PFC相关的认知行为测试受到影响。并且，小鼠内侧前额叶皮层（mPFC）2，3层锥体细胞的突触前兴奋性输入的数量或功能下降，这种下降是由于投射到mPFC的丘脑神经元减少，而非丘脑本身神经元减少。研究者激活这些投射到mPFC区域的丘脑神经元后，发现小鼠与前额叶皮层相关的认知行为测试得到改善。在更深一步研究中，他们发现γ脑电波与β脑电波无法解释青春期丘脑抑制导致成年期行为学异常这一现象。随后，研究者将mPFC中每一个放电的神经元进行关联，发现在行为学测试时，存在一个关联高峰，而青春期丘脑抑制会减弱这个高峰，后续激活丘脑会使得这个高峰增强。这提示青春期时，其他脑区的改变会影响到大脑的前额叶皮层。（导读：Li Xun）文章链接：https://www.nature.com/articles/s41593-022-01072-y图片链接：https://www.piqsels.com/zh/public-domain-photo-zbqclNature | 阿尔茨海默症神经元中积累了更多体细胞突变神经元功能障碍和死亡是阿尔茨海默症（AD）的症状之一，然而引发这一具体事件的生物学机制仍不清晰。近日，来自波士顿的研究人员分析了来自AD患者和正常对照组的319个神经元的单细胞全基因组测序数据，以探究与AD相关的体细胞突变数量、突变位置和突变种类。结果显示，AD神经元中的体细胞突变数目显著增加，且与正常衰老过程中主要是与年龄有关的模式积累突变特征A突变增加不同，AD神经元中由不正常的“灾难性”事件引发的特征C突变显著增多。研究人员推测这些变化可能与核苷酸的氧化相关，并通过实验证实了AD神经元中核苷酸氧化损伤水平上升。此外，AD神经元中的突变具有转录链偏好性，提示转录相关的切除修复可能在产生突变的过程中发挥作用。本研究发现AD神经元中体细胞突变异常积累且氧化应激水平上升，为神经退行性病变和AD的发病机制提供了新的研究线索和潜在的治疗靶点。（导读：海德）原文链接：https://www.nature.com/articles/s41586-022-04640-1图片来源：https://www.google.com.hk/url?sa=i&url=https%3A%2F%2Fwww.genengnews.com%2Fnews%2Fmechanism-that-prevents-the-death-of-neurons-identified%2F&psig=AOvVaw0ldjqwYoqif9TKNyOm7OGe&ust=1653017303790000&source=images&cd=vfe&ved=0CAkQjRxqFwoTCOjEv7vP6vcCFQAAAAAdAAAAABAD
Senior editor Nick Zulovich spent part of his time in Denver for the North American Repossessors Summit sharing another conversation for the Auto Remarketing Podcast with Jeremiah Wheeler, who is president of DRN and MVTRAC. In light of inflation pushing up the costs of gas and other life necessities, Wheeler offered insight stemming from company data about how much consumers are looking to relocate.
The repossession industry is bone-weary from the endless beat-downs by SOME of America's forwarders. Silly excuses to disallow invoices...not passing along fees they collect for services intended to pay field agent...the list goes on and on. Considering inflation, repossessors are getting a fraction of what they were paid 25 years ago. In response, some repossessors in the State of Florida decided to boycott by turning off the LPR cameras that feed data into the system. DRN was caught in the middle, and Jeremiah Wheeler has some thoughts how to best attain the desired results.
In this episode (aired on 12/12/21) Ron DeLegge shares habits from the investing greats that we should apply, plus year-end financial reminders. Ron also answers questions about IBonds. ETFs mentioned in this episode include: MSGR, NAIL, ERX, DRN, SCHB, USCI, REET plus many others. Are you near or already in retirement? Download your investor toolkit today: https://www.etfguide.com/books/
In this episode (aired on 11/21/21) Ron DeLegge explains why the bull market in commodities has legs way beyond inflation. Ron provides ETF tickers to play this theme. Also up: Habits of the Investing Greats and lessons for all. ETFs mentioned in this episode include: CPER, HJEN, FAS, DRN, ERX plus others. Are you near or already in retirement? Get Ron's FREE e-Book https://60-smart-ways.etfguide.com/
In this episode (aired on 11/14/21) Ron DeLegge talks about the SEC's latest rejection of a spot priced bitcoin ETF. Also up: Ron answers questions about target date retirement funds. ETFs mentioned in this episode include: FAS, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 11/07/21) Ron DeLegge breaks down the $1.2 trillion spending bill on U.S. infrastructure and which ETFs will benefit most. Also up: Ron examines it from another angle: the dire ramifications of government overspending on U.S. income tax rates and how to shield yourself from the coming storm. ETFs mentioned in this episode include: KLNE, HJEN, WWOW, RUSL, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 10/31/21) Ron DeLegge gives a rundown of Roth 401k plans and the important role they play in tax-free retirement planning. Also up: Men vs. Women...who's better at investing? Finally, Ron gives you ETF performance updates on BITO, SPY, RUSL, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 10/24/21) Ron DeLegge gives you the 411 on the very first U.S. listed Bitcoin ETF and how it compares to other digital currency linked ETPs. Plus, Ron does audience trivia with the winner getting a signed copy of his book HABITS OF THE INVESTING GREATS. Also up: Ron gives you a performance recap of ETFs in the news like GBTC, SPY, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 10/17/21) Ron DeLegge shows you how to cut your 2021 tax bill with a strategy called tax-loss harvesting. Plus, Ron explains why overall tax positioning of your assets takes priority over tax-loss harvesting. Also up: Ron gives you a performance recap of ETFs in the news like SCHB, BND, DRN, ERX, CHAD, YANG, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode, It's Okay We Ain't Shit has a very special guest on the show up-and-coming rapper, DRN. During the podcast, we talk about everything from people who sleep with the earth to cancel culture. Connect with us on social media and check us out on our other platforms! Instagram The podcast - @itsokaypod Caleb - @clbfshr Soup - @soupgod_ DRN - @drnmcfzl Twitter The podcast - @itsokaypod Caleb - @clbfshr Soup - @soup18_ DRN - @drnmcfzl --- Support this podcast: https://anchor.fm/itsokayweaintshit/support
In this episode (aired on 10/10/21) Ron DeLegge tells you about 5 common retirement distribution pitfalls to avoid. Plus, Ron does audience trivia with the winner getting a signed copy of his book HABITS OF THE INVESTING GREATS. Also up: Ron gives you a performance recap of ETFs in the news like SPY, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 10/03/21) Ron DeLegge explains the SEPT-OBER Effect (September & October combined) and how financial markets have tended to behave during this historically choppy period. You'll also get strategies for navigating it. Plus, Ron answers listener questions on tax-free accounts like Roth IRA and HSA. Also up: Ron gives you a performance recap of ETFs in the news like SPY, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 9/26/21) Ron DeLegge interviews Ed Egilinsky, Managing Director at Direxion Investments about new ETFs that find stocks Wall Street has overlooked. Plus, ways to play the fast growing clean energy sector and one ETF for defensive-minded investors. Also up: Ron gives you a performance recap of ETFs in the news like MDY, IJR, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 9/19/21) Ron DeLegge shares "HABITS OF THE INVESTING GREATS" from Benjamin Graham: The Art of Playing Defense. Also up: Ron gives you a performance recap of ETF marketplace including analysis on funds like FLYT, DRN, ERX, SCHB, REET, USCI and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
Son günlerde Diyanet İşleri Başkanı Prof. Drn. Ali Erbaş'ın Yargıtay Binasının açılışında “cübbesiyle” dua okuması üzerine hortlayan laiklik tartışmaları nasıl bir laiklik anlayışını geride bırakmış olduğumuzu bir daha hatırlattı. “Geride bırakmış” olmaktan söz ediyoruz, ama aslında laiklik adına ilkel, saygısız, marazi ve saldırgan bir tavrın nasıl her an yeniden nüksedecek bir yerde durduğu, canlanmak için fırsat kolladığı da görülüyor. Diyanet İşleri Başkanının dua okuması mı, bunu cübbeyle okuması mı, bunu Yargıtay'ın açılışında yapmış olması mı? Hangisi, hangi laiklik anlayışıyla sorun olarak görülebilir? Açıkçası, bunların herhangi birinin sorun olarak görülmesinin laiklikle değil, aslında tamamen İslam düşmanlığıyla ilgisi var. Laiklik birilerinin İslam düşmanlığını sergilemesi için öne sürülen bir kutsal söz gibi. Tam da bu noktada laikliğin laiklikle hiç alakası olmadığı yere, laikliğin din özgürlüğü değil dine karşı, bilhassa İslam'a karşı bir fobiye veya nefrete dönüştüğü yere tekrar gelmiş oluyoruz ki geride bırakılmış olan, olması gereken laiklik buydu. Laiklikle alakası olmayan laiklik yani.
In this episode (aired on 9/12/21) Ron DeLegge shares battle proven strategies for every type of investor and matching ETF trades. Also up: Ron gives you a performance recap of ETF marketplace including analysis on funds like FLYT, DRN, ERX, NUGT, GLD and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 9/7/21) Ron DeLegge explains the key elements of a properly written investment policy statement (IPS). All investors - new and old - should have one. Also up: Ron gives you a rundown of performance trends in the ETF marketplace including analysis on funds like QYLD, DRN, ERX, SPXL and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
In this episode (aired on 8/15/21) Ron DeLegge talks about investors piling into municipal bonds despite their limited tax-benefits vs. other tax-free choices . Also up: Stock market trivia PLUS, Ron gives you a rundown of trends in global financial markets. ETFs mentioned in this episode include DRN, ERX, FAS, SCHB, BND, USCI, REET and others. Are you near or already in retirement? Get Ron's FREE e-Book: https://60-smart-ways.etfguide.com/
Pat was walking his dog, Tank, one morning and thought of a few more questions to ask DRN's Jeremiah Wheeler. Thanks, Jeremiah, for taking the call.
LPR technology's success in America is based on their efforts and good will of their agents in the field....and DRN knows it. DRN's Jeremiah Wheeler talks with Pat about their efforts to build the strongest agent network possible, and how they intend to do that through revenue sharing, cooperation....and a sense of fair play.
On our latest episode Shana with Maya K. van Rossum. Maya is the Delaware Riverkeeper and founder of the grassroots non-profit Green Amendments For the Generations. She is the leader of the Delaware Riverkeeper Network, who works throughout the four states of the Delaware River watershed (NY, NJ, PA & DE) and at the national level using advocacy, science, and litigation. van Rossum, who is skilled as an author, environmental attorney, strategist, community organizer, facilitator, coalition builder, and manager, has led DRN for over 25 years. She is the author of a book titled, The Green Amendment, Securing Our Right to a Healthy Environment. She is currently seeking to inspire and secure constitutional protection for environmental rights across the nation and since launching Green Amendments For The Generations, constitutional amendments have been proposed in New York, New Jersey, Maryland, Vermont, and West Virginia. Together Shana and Maya discussed many important topics concerning the environment in Pennsylvania. They talked extensively about how the oil and gas industry has been toxic to our state in several ways, most importantly the destruction it has caused. During their conversation, Maya and Shana talked about the grand jury report that was released by PA's Attorney General, Josh Shapiro in late June 2020. In addition, the AG also issued indictments of several companies, and there is an ongoing investigation that could lead to criminal charges. Most importantly Maya and Shana talked about PA's Green Amendment, it's history, and how it plays a critical role in investigations like the Attorney General's grand jury report. Maya stressed the importance of Pennsylvania's Green Amendment of how we need to learn about all our inalienable rights as Pennsylvanians including a healthy environment and climate. Maya has hope that one day soon there will be a Green Amendment in every state, not just in Pennslyvania. That is only possible if we work together and fight for a better tomorrow.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.27.222729v1?rss=1 Authors: Cho, J. R., Chen, X., Kahan, A., Robinson, E., Wagenaar, D. A., Gradinaru, V. Abstract: The ability to recognize motivationally salient events and respond to them adaptively is critical for survival. Here we tested whether dopamine (DA) neurons in the dorsal raphe nucleus (DRN) contribute to this process. Population recordings of DRNDA neurons during associative learning tasks showed that their activity dynamically tracks salience, developing excitation to both reward- and punishment-paired cues. The DRNDA response to reward-predicting cues was diminished after satiety, suggesting modulation by internal states. DRNDA activity was also greater for unexpected outcomes than for expected outcomes. Two-photon imaging of DRNDA neurons demonstrated that the majority of individual neurons developed activation to reward predicting cues but not to punishment-predicting cues, which was surprising and qualitatively distinct from the population results. Head-fixation during fear learning abolished the neural response to aversive cues, indicating modulation by behavioral context. Overall, these results suggest that DRNDA neurons encode motivational salience, dependent on internal and external factors. Copy rights belong to original authors. Visit the link for more info
In a preview of what he will discuss in more detail during the all-digital Automotive Intelligence Summit, DRN executive vice president and general manager of fintech Jeremiah Wheeler offered some insight about the company’s location data gathered since the coronavirus pandemic began. Wheeler is also among the keynote presenters during the Auto Intel Summit presented by DRN that begins on July 27.
Sinixta Soundz Underground Mix 32 Mix w/ DJ Lord Sinixta of UGS Radio Playlist Includes: Big Floyd, Slave Kamp, Akseann, Lunatic, DRN, MC2 and J Dog, Guce, ,Big Black, Black, Hystables, Mr Quikk, Southern Sinn in Memory of Big Floyd of Screwed Up Click
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.28.172460v1?rss=1 Authors: Petrucci, A. N., Joyal, K. G., Li, R., Chou, J. W., Vencer, K. M., Buchanan, G. F. Abstract: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. A proposed risk marker for SUDEP is the duration of post-ictal generalized EEG suppression (PGES). The mechanisms underlying PGES are unknown. Serotonin (5-HT) has been implicated in SUDEP pathophysiology. Seizures suppress activity of 5-HT neurons in the dorsal raphe nucleus (DRN). We hypothesized that suppression of DRN 5-HT neuron activity contributes to PGES and increasing 5-HT neurotransmission or stimulating the DRN before a seizure would decrease PGES duration. Adult C57BL/6 and Pet1-Cre mice received EEG/EMG electrodes, a bipolar stimulating/recording electrode in the right basolateral amygdala, and either a microdialysis guide cannula or an injection of adeno-associated virus (AAV) allowing expression of channelrhodopsin2 plus an optic fiber into the DRN. Systemic application of the selective 5-HT reuptake inhibitor citalopram (20 mg/kg) decreased PGES duration from seizures induced during wake (n = 23) and NREM sleep (n = 13) whereas fluoxetine (20 mg/kg) pretreatment decreased PGES duration following seizures induced from wake (n = 11), but not NREM sleep (n = 9). Focal chemical (n = 6) or optogenetic (n = 8) stimulation of the DRN reduced PGES duration following kindled seizures and reduced morality following maximal electroshock seizures (n = 6) induced during wake. During PGES, animals exhibited immobility and suppression of EEG activity that was reduced by citalopram pretreatment. These results indicate that 5-HT and the DRN may regulate PGES and seizure-induced mortality. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.25.171637v1?rss=1 Authors: Cazettes, F., Reato, D., Morais, J. P., Renart, A., Mainen, Z. F. Abstract: Variations in pupil size under constant luminance are closely coupled to changes in arousal state. It is assumed that such fluctuations are primarily controlled by the noradrenergic system. Phasic activity of noradrenergic axons precedes pupil dilations associated with rapid changes in arousal, and is believed to be driven by unexpected uncertainty. However, the role of other modulatory pathways in the control of pupil-linked arousal has not been as thoroughly investigated, but evidence suggests that noradrenaline may not be alone. Administration of serotonergic drugs seems to affect pupil size, but these effects have not been investigated in detail. Here, we show that transient serotonin (5-HT) activation, like noradrenaline, causes pupil-size changes. We used phasic optogenetic activation of 5-HT neurons in the dorsal raphe nucleus (DRN) in head-fixed mice locomoting in a foraging task. 5-HT-driven modulations of pupil size were maintained throughout the photostimulation period and sustained for several seconds after the end of the stimulation. The activation of 5-HT neurons increased pupil size additively with locomotor speed, suggesting that 5-HT transients affect pupil-linked arousal independently from locomotor states. We found that the effect of 5-HT on pupil size depended on the level of environmental uncertainty, consistent with the idea that 5-HT may report a salience or surprise signal [24]. Together, these results challenge the classic view of the neuromodulatory control of pupil-linked arousal, revealing a tight relationship between the activation of 5-HT neurons and changes in pupil size. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.25.171470v1?rss=1 Authors: Siemann, J. K., Williams, P., Malik, T. N., Jackson, C., Green, N. H., Emeson, R., Levitt, P., McMahon, D. G. Abstract: Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain monoamine content in mice raised under control Equinox (LD 12:12), Short winter-like (LD 8:16), or Long summer-like (LD 16:8) photoperiods. Focusing in early adulthood, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels in the dorsal raphe nucleus (DRN) with RNAScope. Mice that developed under Short photoperiods demonstrated elevated midbrain TH expression levels, specifically during perinatal development compared to mice raised under Long photoperiods, and significantly decreased serotonin and dopamine content throughout the course of development. In adulthood, Long photoperiod mice demonstrated decreased midbrain Tph2 and SERT expression levels and reduced Tph2 levels in the DRN compared Short photoperiod mice. Thus, evaluating gene x environment interactions in the dopaminergic and serotonergic systems during multiple stages of development may lead to novel insights into the underlying mechanisms in the development of affective disorders. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.16.154492v1?rss=1 Authors: Hedges, V. L., Heaton, E. C., Amaral, C., Benedetto, L. E., Bodie, C. L., D'Antonio, B. I., Davila Portillo, D. R., Lee, R. H., Levine, M. T., O'Sullivan, E. C., Pisch, N. P., Taveras, S., Wild, H. R., Ross, A. P., Albers, H. E., Been, L. E. Abstract: Background: Estrogen increases dramatically during pregnancy, but quickly drops below pre-pregnancy levels at birth and remains suppressed during the postpartum period. Clinical and rodent work suggests that this postpartum drop in estrogen results in an "estrogen withdrawal" state that is related to changes in affect, mood, and behavior. Most studies examining the effect of estrogen withdrawal on the brain have focused solely on the hippocampus. Methods: We used a hormone-simulated pseudopregnancy model in Syrian hamsters, a first for this species. Ovariectomized females were given daily injections to approximate hormone levels during gestation and then withdrawn from estrogen to simulate postpartum estrogen withdrawal. Subjects were tested for behavioral assays of anxiety and anhedonia during estrogen withdrawal. Following sacrifice, neuroplasticity in oxytocin-producing neurons in the paraventricular nucleus of the hypothalamus (PVH) and its efferent targets was measured. Results: Estrogen-withdrawn females had increased anxiety-like behaviors in the elevated plus and open field, but did not differ from controls in sucrose preference. Furthermore, estrogen-withdrawn females had more oxytocin-immunoreactive cells and oxytocin mRNA in the PVH, as well as an increase in oxytocin receptor density in the dorsal raphe nucleus (DRN). Finally, blocking oxytocin receptors in the DRN during estrogen withdrawal prevented the high-anxiety behavioral phenotype in estrogen-withdrawn females. Conclusions: Estrogen withdrawal alters oxytocin signaling in the PVH and DRN to increase anxiety-like behavior during the postpartum period. More broadly, these experiments suggest Syrian hamsters as a novel organism in which to model the effects of postpartum estrogen withdrawal on the brain and anxiety-like behavior. Copy rights belong to original authors. Visit the link for more info
After being one of the experts who participated during a webinar orchestrated by DRN in April, Receivables Management Association International executive director Jan Stieger discussed collections and more during this special episode. Stieger also touched on how well auto-finance companies and other creditors have worked with their customers who have been negatively impacted during the coronavirus pandemic.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.15.098319v1?rss=1 Authors: Levinstein, M. R., Coffey, K. R., Marx, R. G., Lesiak, A. J., Neumaier, J. F. Abstract: The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. The three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and the rostromedial tegmental nucleus (RMTg). LHb neurons that project to these targets are segregated and nonoverlapping, and this led us to consider whether they have distinct molecular phenotypes and adaptations to stress exposure. In order to capture a time-locked profile of gene expression after repeated forced swim stress, we used intersectional expression of RiboTag in rat LHb neurons and next-gen RNA sequencing to interrogate the RNAs actively undergoing translation from each of these pathways. The "translatome" in the neurons comprising these pathways was similar at baseline, but diverged after stress, especially in the neurons projecting to the RMTg. Using weighted gene co-expression network analysis, we found one module comprising genes downregulated after stress in the RMTg-projecting LHb neurons; there was an overrepresentation of genes associated with phosphoinositide 3 kinase (PI3K) signaling in this module. Reduced PI3K signaling in RMTg-projecting LHb neurons may be a compensatory adaptation that alters the functional balance of LHb outputs to GABAergic vs. monoaminergic neurons following repeated stress exposure. Copy rights belong to original authors. Visit the link for more info
Sinixta Soundz Underground Mix 31 Mix w/ DJ Lord Sinixta of UGS Radio Playlist Includes: Lord Sinixta, Extra Prolific, Mad Skillz, Inner City Mob, Reno's Most Wanted, Poetic Lordz, I-Roc, Southern Sinn, DRN, Main Source, Radio, Parafanellya, C Corleone, Boom 40, Capital "B", Smiffey, DJ DMD
First, we speak to Joanna Stern from the WSJ, who asked a certified ethical hacker to get into as many of her webcams as he could. He was easily able to get into her system, snap shots of her and even spy on her child through a Wi-Fi connected baby monitor. Joanna joins us for some tips on how to protect yourself, and the big realization, we are often our own worst enemies. Next, a company call Digital Recognition Network has built a private, nationwide surveillance database that could potentially track the movements of car owners over long periods of time. This network is built on the backs of repo men equipped with cameras that scan the license plates of every car they drive by and then add it to a searchable database accessible to private investigators, repo agents, and insurance companies. Joseph Cox, senior writer at the Vice's Motherboard, joins us to talk about DRN and how well it works, Vice tracked someone using this surveillance tool. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com
In this episode (aired on 10/27/19), host Ron DeLegge talks about some the biggest and most important investing themes right now with Sylvia Jablonski @ Direxion Investments. ETFs mentioned in this episode include ticker symbols RWGV, RWUI, CURE, PILL, DRN, along with the Fear Greed Index. Follow the show on Twitter @IndexShow and order Ron's new book at: https://www.amazon.com/gp/product/B07T2PJDN3/ref=dbs_a_def_rwt_bibl_vppi_i0
In this episode (aired on 10/20/19), host Ron DeLegge re-examines trading rules for ETF investors. Also, how much of your investment results are attributable to luck? ETFs mentioned in this episode include ticker symbols XLV, CURE, XLRE, DRN, along with the Fear Greed Index. Follow the show on Twitter @IndexShow and order Ron's new book at https://www.amazon.com/gp/product/B07T2PJDN3/ref=dbs_a_def_rwt_bibl_vppi_i0
Are low interest rates and yields devouring your cash flow? In this episode (aired on 10/6/19), host Ron DeLegge examines better alternatives to low yielding brokerage cash and money market accounts. Also up: Ron does trivia from his new book HABITS OF THE INVESTING GREATS, win your signed copy! ETFs mentioned in this episode include ticker symbols SCHB, BND, NUGT, DRN, USCI, SCHO, SHY, REET, and BSV. Follow the show on Twitter @IndexShow and order Ron's new book at Amazon.com: https://www.amazon.com/gp/product/B07T2PJDN3/ref=dbs_a_def_rwt_bibl_vppi_i0
President Trump announced that he has selected the Special Presidential Envoy for Hostage Affairs, Robert O'Brien to be the new National Security Adviser. O'Brien will be the fourth person to hold the job in Trump's first term. The president thinks he will be a good pick because he has been successful at getting hostages released from abroad. Alayna Treene, reporter for Axios, joins us for what to know about Trump's new pick. Next, a company called Digital Recognition Network has built a private, nationwide surveillance database that could potentially track the movements of car owners over long periods of time. This network is built on the backs of repo men equipped with cameras that scan the license plates of every car they drive by and then add it to a searchable database accessible to private investigators, repo agents, and insurance companies. Joseph Cox, senior writer at Vice's Motherboard, joins us to talk about DRN and how well it works, Learn more about your ad-choices at https://www.iheartpodcastnetwork.com
In this episode (aired on 9/15/19), host Ron DeLegge compares three different retirement portfolios, explains their very different outcomes and what it means for retirees and pre-retirees. Also up: Ron does trivia from his new book HABITS OF THE INVESTING GREATS, win your signed copy! ETFs mentioned in this episode include ticker symbols SCHB, SPXL, DRN, TECL, and XLK. Follow the show on Twitter @IndexShow and order Ron's new book at Amazon.com: https://www.amazon.com/gp/product/B07T2PJDN3/ref=dbs_a_def_rwt_bibl_vppi_i0
DRN’s Jeremiah Wheeler recapped his TED-style presentation during this summer’s Auto Intel Summit along with looking ahead to Used Car Week, which begins on Nov. 11 in Las Vegas.
In this episode (aired on 7/7/19), host Ron DeLegge shares excerpts from his upcoming book "Habits of the Investing Greats" and lessons from Sir John Templeton. Also, Ron explains why so much money has flooded into bond ETFs. Finally, Ron provides the latest global market trends with performance updates. ETFs discussed in this episode include ticker symbols DRN, WANT, NEED, TECL, LABU, SCHB, VWO, USCI, GLD and USO. Pre-order Ron's upcoming book at Amazon.com: https://www.amazon.com/gp/product/B07T2PJDN3/ref=dbs_a_def_rwt_bibl_vppi_i0
From the depths of the Florida summer, Corrupting the Youth has returned! Join us as we discuss philosophical questions related to the Netflix series “Russian Doll,” and get side-tracked talking about DRN’s new Red Dead Redemption 2 addiction. Topics: Remorse, Existentialism, and Death.
In this episode (aired on 6/16/19), host Ron DeLegge defines the proactive investor and how to become one. The idea is to help you to cultivate the right mindset and habits for optimal investment results. ETFs discussed in this episode include ticker symbols SCHB, NUGT, DRN, XLK, XLRE, and UTSL. Lastly, Ron shares the latest year-to-date ETF performance numbers within major industry sectors and global markets. Follow us on Twitter @ IndexShow
In this episode (aired on 6/2/19), host Ron DeLegge identifies things that could be hindering your retirement plan. ETFs discussed include ticker symbols SCHB, XLK, TECL, XLRE, DRN, and USCI. Also, Ron tells you a true life story about how a sinking skyscraper located in S.F. is related to how you invest. Finally, you get the latest year-to-date ETF performance numbers within major industry sectors and global markets. Follow us on Twitter @ IndexShow
Consider this episode of the Auto Remarketing Podcast a preview of what’s to come during Used Car Week 2018. Joining Nick for this edition are representatives from two presenting sponsors — Anne Holtzman of Allied Solutions and Jeremiah Wheeler of DRN — who offer a glimpse of their presentations focused on how watching insurance data can be a great way to mitigate risk in connection with repossessions and recoveries.
Attorney and activist Maya van Rossum, author of The Green Amendment: Securing Our Right to a Healthy Environment discusses a pioneering new legal strategy to fight growing pollution problems, including drinking water contamination, air pollution, deforestation and climate change, by adopting constitutional green amendments that guarantee a safe and healthy environment. Van Rossum is also the leader of the Delaware Riverkeeper Network, an organization that has successfully stalled fracking and pipeline development in the Northeast. The DRN initiated For the Generations, a project that provides a guide to creating an environmental rights amendment in every US state. This veteran environmentalist used the constitution in Pennsylvania to take on and beat big fossil fuel industries, and how these amendments could change the legal landscape to crises such as Flint, Keystone, ad beyond. Van Rossum believes that environmental rights are a fundamental human right, just like free speech and the right to private property.
Jeremiah Wheeler, vice president of financial services at DRN, returns to the Auto Remarketing Podcast as Nick hosts a discussion about the impact technology is having on vehicle repossessions. We also touch on the special segments at Used Car Week that includes Jeremiah and DRN, which is the presenting sponsor of Auto Fin Con.
After a long disappearance Mr. Jason White returns to the Herp community and reprises his role as our favorite news anchor..well besides Steve Barker of course. Join us Sunday at 8:00 PM EST to find out what Jay has been up to, why he took a break, and what's in his plans for the future of DRN. Check him out on Youtube at www.youtube.com/user/dailyreptilenews Join us in our chatroom while the show is going on. The chatroom works best with Google and Firefox browsers. Follow us on facebook at www.facebook.com/GeckoNationRadio
AFTERBUZZ TV — Almost Human edition, is a weekly “after show” for fans of Almost Human. In this episode host Matt Lieberman breaks down the episode in which an advanced DRN goes rogue after being rebuilt, but behaves more like … Read the rest The post Almost Human S:1 | Unbound E:9 | AfterBuzz TV AfterShow appeared first on AfterBuzz TV Network.
Episode six of FOX’s sci-fi cop procedural, Almost Human aired on December 16, 2013 and is entitled, “Arrhythmia.” In episode 08 of the Almost Human Podcast we discuss the episode and give our full review. Joined in studio by Ruthie Rink, we discuss this episode which gave us a double dose of the DRN, presented […] The post Almost Human Podcast Episode 08-Arrhythmia Review appeared first on Golden Spiral Media- Entertainment Podcasts, Technology Podcasts & More.
Episode six of FOX’s sci-fi cop procedural, Almost Human aired on December 16, 2013 and is entitled, “Arrhythmia.” In episode 08 of the Almost Human Podcast we discuss the episode and give our full review. Joined in studio by Ruthie Rink, we discuss this episode which gave us a double dose of the DRN, presented […] The post Almost Human Podcast Episode 08-Arrhythmia Review appeared first on Golden Spiral Media- Entertainment Podcasts, Technology Podcasts & More.
Almost Human episode 6 entitled, “Arrhythmia” aired on December 16, 2013 and here are my initial thoughts on this Almost Human episode. “Arrhythmia” was originally produced to be aired as the 3rd episode of the series and I believe that was clear in a couple of areas. The conversations and background of the DRN models […] The post Almost Human 1×06 Arrhythmia First Impressions appeared first on Golden Spiral Media- Entertainment Podcasts, Technology Podcasts & More.
Almost Human episode 6 entitled, “Arrhythmia” aired on December 16, 2013 and here are my initial thoughts on this Almost Human episode. “Arrhythmia” was originally produced to be aired as the 3rd episode of the series and I believe that was clear in a couple of areas. The conversations and background of the DRN models […] The post Almost Human 1×06 Arrhythmia First Impressions appeared first on Golden Spiral Media- Entertainment Podcasts, Technology Podcasts & More.
Drn drn! RedLynxin Ville Veihola karauttaa etupyörä ilmassa Nelinpeli-studioon, jossa tällä kertaa jaellaan juonipaljastuksia ja hikoillaan teknisten haasteiden äärellä.
Tune in as Danny & Andy come back HARD with tantalizing topics that will astound and Amaze. Tonight we'll be joined by Jason White of DRN as he delivers the news and so much more...join us won't you?
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.21.053892v1?rss=1 Authors: Zweifel, L. S., Fellinger, L., Jo, Y. S., Hunker, A. C., Soden, M. E. Abstract: Discrimination between predictive and non-predictive threat stimuli decrease as threat intensity increases. The central mechanisms that mediate the transition from discriminatory to generalized threat responding remain poorly resolved. Here, we identify the stress- and dysphoria-associated kappa opioid receptor (KOR) and its ligand dynorphin (Dyn), acting in the ventral tegmental area (VTA), as a key substrate for regulating threat generalization. We identified several dynorphinergic inputs to the VTA and demonstrate that projections from the bed nucleus of the stria terminalis (BNST) and dorsal raphe nucleus (DRN) both contribute to anxiety-like behavior but differentially affect threat generalization. These data demonstrate that conditioned threat discrimination has an inverted -U- relationship with threat intensity and establish a role for KOR/Dyn signaling in the midbrain for promoting threat generalization. Copy rights belong to original authors. Visit the link for more info
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