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Methylene blue is widely marketed over the counter to the general public as well as to the natural health, health freedom, and freedom communities, often on the internet. It is flooding America. Some sellers are touting methylene blue as a “miracle” tonic that improves “cognitive function”1 and boosts energy to previously unimagined heights. Some have given live demonstrations on TV and podcasts demonstrating how the oral form hyperactivates some people within 35 minutes of the first dose — a typical stimulant drug rush — which is actually a danger signal for potentially activating them into a dangerous manic episode during future exposures or even more deadly outcomes. Read the full article here: Methylene Blue is highly neurotoxic to your brain and mind In reality, methylene blue is a lethal neurotoxin, a poison to the brain. It has the same basic chemical composition and harmful clinical effects as the oldest and most neurotoxic “antidepressants,” the monoamine oxidase inhibitors (MAOIs). It also has similarities to the neurotoxic phenothiazine “antipsychotic” drugs, including the original Thorazine (chlorpromazine), but methylene blue is more stimulating or activating. Methylene blue is not a miraculous new discovery. It is the opposite. Created in 1876 in a lab — it is the oldest manmade chemical to be used in medicine. But in well over a century, methylene blue has never been FDA-approved for psychiatric purposes. Later, its chemical structure was modified in labs for creating many of the earliest, most neurotoxic psychiatric drugs. Methylene blue suppresses or destroys forms of the enzyme monoamine oxidase that are used by the brain for controlling or modulating four different powerful neurotransmitters — serotonin, dopamine, norepinephrine, and epinephrine. In short, by crushing monoamine oxidase, methylene blue causes overstimulation of four of the brain's major neurotransmitters, all of which profoundly impact the mind. After the FDA was created in 1906, methylene blue was grandfathered into the market by the agency as an obscure antidote for methemoglobinemia, but it must be emphasized that the FDA has never tested the safety of methylene blue for any purpose. Furthermore, the FDA, based on its adverse reporting system and scientific reports, has published serious warnings about potentially lethal adverse reactions from methylene blue, especially when combined with numerous other drugs.2 The first MAOIs used as depressants were derived from methylene blue, and they turned out to be so toxic that the first two were quickly taken off the market by the FDA. One caused lethal liver disease, and the other caused hypertensive crises. Methylene blue is known to impair liver function tests and to cause hypertensive crises. Early on, all MAOIs were removed for a while from the international list of approved drugs. Please go to this endnote in my report for a list of historical and scientific studies about the extraordinary history and the nature of methylene blue and the other MAOIs.3 Psychiatry and the psychopharmaceutical complex are so driven to impose neurotoxins upon our brains ⎯ some MAOI antidepressants remain on the market today. FDA Full Prescribing Information for the existing MAOI antidepressants, readily available online,4 provides quick access to the kinds of adverse effects caused by methylene blue. These FDA documents also provide lists of the foods and of some of the many, many drugs you cannot take with MAOIs, like methylene blue, without risking death from serotonin syndrome or a hypertensive crisis. Meanwhile, all of America is being made a market for the original mother of them all, methylene blue, without requiring a prescription, with bizarrely distorted claims, and with unlimited supplies handed out as easily as a new caffeinated soda. All of the three approved MAOIs, as well as methylene blue, carry repeated warnings at the FDA and in the scientific community about causing the two potentially crippling and lethal outcomes, serotonin syndrome and malignant hypertension (see below). These potentially lethal outcomes, as with all MAOIs, become much more serious and higher risk when methylene blue is taken with certain foods such as cheese and bananas, or literally with so many other drugs that it is impossible to memorize them or to keep track of them. Here is one version of a short summary of the long list of dangerous interactions between MAOIs, including methylene blue, and other drugs and foods, taken from Goodman and Gilman's The Pharmacological Basis of Therapeutics (2018, p. 274): Monoamine Oxidase Inhibitors Serotonin syndrome is the most serious drug interaction for the MAOIs (see Adverse Effects). The most common cause of serotonin syndrome in patients taking MAOIs is the accidental coadministration of a SHT reuptake-inhibiting antidepressant or tryptophan. Other serious drug interactions include those with meperidine and tramadol. MAOIs also interact with sympathomimetics such as pseudoephedrine, phenylephrine, oxymetazoline, phenylpropanolamine, and amphetamine; these are commonly found in cold and allergy medication and diet aids and should be avoided by patients taking MAOIs. Likewise, patients on MAOIs must avoid foods containing high levels of tyramine: soy products, dried meats and sausages, dried fruits, home-brewed and tap beers, red wine, pickled or fermented foods, and aged cheeses. I am presenting this detailed summary in the hope of gaining the immediate attention of people and businesses who are promoting methylene blue and anyone who is unfortunately taking it. Please share this summary or the entire document as widely as possible and with proper attribution. An extensive article follows, detailing my professional experience in the arena of psychopharmacology. It includes a lengthy scientific analysis with more than two dozen endnotes containing an even greater number of scientific citations. Read the full article here: Methylene Blue is highly neurotoxic to your brain and mind End Notes 1 All stimulants from caffeine to Ritalin (methylphenidate) and on to methamphetamine and cocaine, and including MAOIs, can produce subjective feelings of improved concentration or memory, and some short-term studies show a brief improvement. This is caused by obsessive-compulsive mental focusing and is driven by a narrowing of general awareness and judgment. No FDA-approved stimulants, for example, have been proven to help cognition or academic performance, and all harm the brain long-term. Here is a study that is negligent in its claims and its lack of warnings about methylene blue that may have encouraged the current epidemic use: https://psychiatryonline.org/doi/full/10.1176/appi.pn.2016.pp8a5 I have researched these issues in multiple scientific papers and books, including Brain-Disabling Treatments in Psychiatry: Drugs, Electroshock, and the Psychopharmaceutical Complex, second edition (2008). For an easily accessible, comprehensive look at stimulant drug effects, also see my free resource center on children and stimulant medications: https://breggin.com/Childrens-Resources-Center 2 Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications | FDA and FDA Drug Safety Communication: Updated information about the drug interaction between methylene blue and Drug Safety Podcasts > FDA Drug Safety Podcast for Healthcare Professionals: Updated information about the drug interaction between methylene blue and serotonergic psychiatric medications (methylthioninium chloride) and serotonergic psychiatric medications | FDA and much more comprehensive coverage of methylene blue adverse effects with special warnings for professionals can be found at Methylene Blue Monograph for Professionals – Drugs.com 3 Half_a_century_of_antidepressant_drugs_-20151101-21548-vmvosk-libre.pdf. Also see Methylene Blue: The Long and Winding Road From Stain to Brain: Part 2 – PubMed and Methylene Blue in the Treatment of Neuropsychiatric Disorders – PubMed; and Iproniazid | Antidepressant, Monoamine Oxidase Inhibitor & Mental Health | Britannica; Methylene Blue: The Long and Winding Road From Stain to Brain: Part 2 – PubMed; Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today – PubMed. These cover the fascinating history of MAOIs and Methylene Blue. 4 The currently approved MAOI antidepressants are phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldpryl, Emsam, Zelapar)), and isocarboxazid (Marplan). ______ Learn more about Dr. Peter Breggin's work: https://breggin.com/ See more from Dr. Breggin's long history of being a reformer in psychiatry: https://breggin.com/Psychiatry-as-an-Instrument-of-Social-and-Political-Control Psychiatric Drug Withdrawal, the how-to manual @ https://breggin.com/a-guide-for-prescribers-therapists-patients-and-their-families/ Get a copy of Dr. Breggin's latest book: WHO ARE THE “THEY” - THESE GLOBAL PREDATORS? WHAT ARE THEIR MOTIVES AND THEIR PLANS FOR US? HOW CAN WE DEFEND AGAINST THEM? Covid-19 and the Global Predators: We are the Prey Get a copy: https://www.wearetheprey.com/ “No other book so comprehensively covers the details of COVID-19 criminal conduct as well as its origins in a network of global predators seeking wealth and power at the expense of human freedom and prosperity, under cover of false public health policies.” ~ Robert F Kennedy, Jr Author of #1 bestseller The Real Anthony Fauci and Founder, Chairman and Chief Legal Counsel for Children's Health Defense.
Send us a message!In this episode we will be covering Facebook Live Questions 4/21-4/27/25 from Dana's free Facebook Group Registered Dietitian Exam Study Group with Dana RD!Get the free RD Exam Prep Masterclass here. Looking for additional tutoring service? Visit my website! Shop all recorded courses at https://danajfryernutritiontutoring.teachable.comJoin the RD Exam Prep Mastery Program for access to the Situational Practice Questions, Vocab Classes, Wed 8pest Group tutoring , study guides and a new trouble area video each week!
In this week's Talking Travel, Rory takes us on a trip to Easter Island - famous for its carved stone statues and for being one of the most remote inhabited islands in the world.
Welcome back! Today, we will be discussing MAOIs, and we've picked out a few of our favorites for today's episode.
High Yield Psychiatric Medications Antidepressants Review for your PANCE, PANRE, Eor's and other Physician Assistant exams. Review includes SSRI's, SNRIs, TCAs, MAOIs, Atypical antidepressants, Serotonin modulators. TrueLearn PANCE/PANRE SmartBank:https://truelearn.referralrock.com/l/CRAMTHEPANCE/Discount code for 20% off: CRAMTHEPANCEIncluded in review: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Desvenlafaxine, Duloxetine, Levomilnacipran , Milnacipran, Venlafaxine, Amitriptyline, Clomipramine, Doxepin, Imipramine, Trimipramine, Desipramine, Nortriptyline, Protriptyline, Tranylcypromine, Isocarboxazid, Phenelzine Selegiline, Bupropion, Mirtazapine, Trazodone
In this episode, Nutrition Coach Lucas Schmidt talks about the foods that interfere with MAOI drugs and Levothyroxine. Remember to always ask your doctor questions about food-drug interactions! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine
We are going to combine all of our favorite topics — red light therapy, the mitochondria and methylene blue — into this brain-centric episode. We know that the brain is the most mitochondrial-dense tissue in the body and, thus, photobiomodulation (namely, near-infrared light) can have a very positive effect. We also know that most of the methylene blue ingested eventually accumulates in the brain, which is why it has countless brain-boosting benefits. However, when it comes to mitochondrial function it's a double-edged sword. The health of your mitochondria can (of course) work for you or against you. And when the function of your mitochondria declines, it will likely show up in those tissues that are mitochondrial-dense (i.e., tissues that require the most amount of energy to function). Our nervous system is extremely energy-intensive and the brain is the king/queen of the nervous system. Thus, when mitochondrial dysfunction strikes, it hits the nervous system — and particularly the brain — hard. This largely explains why neurodegenerative diseases are an every-increasing presence in our modern-day world. While this may all seem like sobering and dire news, there is a silver lining that can put you back at ease. Again, while mitochondrial dysfunction can work against you, as long as you harness tactics that boost mitochondrial health (and, thus, inherently prevent, mitigate and sometimes even reverse mitochondrial dysfunction), then you are well on your way to staving off neurodegenerative disease. In today's episode, methylene blue takes center stage as we dig into the research to see how this spectacular salt can buoy your mitochondrial health and play a pivotal role in numerous neurodegenerative diseases. As always, light up your health! - Key Points: Intro & Weather (00:00:00 - 00:02:25) Montana weather update and Dr. Mike's snow aversion Holidays & BioLight Sale (00:02:25 - 00:03:24) Mention of approaching holidays Announcement of pre-Black Friday sale at BioLight Upcoming Interviews & Office Hours (00:03:24 - 00:05:53) Encouragement to subscribe and introduction of Instagram Live office hours Details about the purpose, structure, and inaugural session of office hours Significance of two-way communication and bridging gaps in red light therapy education Main Topic: Mitochondrial Dysfunction (00:12:03 - 00:15:14) Introduction and eagerness to explore mitochondrial dysfunction Consequences and treatment strategies discussed Microtherapy and Treatment Strategies (00:18:24 - 00:21:19) Introduction to "microtherapy" and various treatments Announcement of an e-book Mitochondria's Role in Health (00:21:19 - 00:24:16) Emphasis on overall health and lifestyle impact Exploring Methylene Blue (00:24:16 - 00:26:54) Introduction to "From Mitochondrial Function to Neuroprotection" Historical background and BioLight product announcement Methylene Blue's Mechanisms (00:26:54 - 00:30:05) Effectiveness, historical evolution, psychiatric applications, and MAOI function discussed Mitochondrial Function and Methylene Blue (00:30:05 - 00:33:07) Importance of mitochondrial function and overview of the electron transport chain Methylene Blue's Role in Mitochondrial Dysfunction (00:33:07 - 00:35:52) Promotion of complex four activity Tau aggregation in Alzheimer's Methylene Blue in Alzheimer's and Parkinson's (00:35:52 - 00:37:12) Preservation of electron transport chain function Behavioral improvements in Parkinson's Benefits and Combination Therapy (00:37:12 - 00:39:21) Potential benefits with levodopa and emphasis on investigating safety Methylene Blue in Traumatic Brain Injury (00:39:21 - 00:40:01) Transition to TBI discussion Encouragement to use remedies promptly Preclinical Studies on Methylene Blue (00:40:01 - 00:41:15) Overview of TBI studies and quick administration's impact on outcomes Effectiveness of Methylene Blue (00:41:15 - 00:43:37) Studies showing effectiveness post-TBI Likelihood of combination therapy efficacy Cognitive Enhancement and Aging (00:43:37 - 00:52:40) Exploration of cheaply available compounds and Methylene Blue's potential in cognitive enhancement Protection against age-related decline Neurogenesis and mitochondrial health Conclusion and BioLight Product (00:52:40 - 00:55:53) Summary of article focus and BioLight's enhanced methylene blue product Closing (00:55:58:15 - 00:56:53:08) Dr. Mike's recommendation to explore BioBlue Encouragement to share information - Articles referenced in the episode: Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue - Learn more about methylene blue & BioBlue: Methylene blue BioBlue - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics - To learn more about red light therapy, methylene blue and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn BioLight: Instagram YouTube Facebook
YouTube Video & Podcast Description:
Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name hydromorphone Trade Name Dilaudid Indication moderate to severe pain Action alters the perception and reaction to pain by binding to opiate receptors in the CNS, also suppresses the cough reflex Therapeutic Class Opioid Analgesic, allergy, cold and cough remedies, antitussive Pharmacologic Class opioid agonist Nursing Considerations • Assess BP, respirations, and pulse before and during administration – medication causes general CNS depression • Narcan (nalaxone) is the antidote for overdose • use caution with concurrent use of MAOI – avoid use within 14 days of each other • may be used as an antitussive • advised to dilute with NS prior to administration and to administer slowly to decrease CNS depression
Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name hydrocodone/acetaminophen Trade Name Vicodin, Lortab, Norco Indication management of moderate to severe pain Action alters the perception and reaction to pain by binding to opiate receptors in the CNS, also suppresses the cough reflex Therapeutic Class opioid Analgesic, allergy, cold and cough remedies, antitussive Pharmacologic Class opioid agonists, nonopioid analgesic combinations Nursing Considerations • use caution with concurrent use of MAOI – avoid use within 14 days of each other • hypotension – monitor hemodynamics and respirations after administering • may increase ICP use caution with head trauma • Narcan (nalaxone) is the antidote for overdose • DO NOT exceed 4g of acetaminophen per day
Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name Epinephrine Trade Name Adrenalin, EpiPen Indication Asthma and COPD exacerbations, allergic reactions, cardiac arrest, anesthesia adjunct Action Affects both beta1 and beta2 also has alpha agonist properties resulting in bron- chodilation and increases in HR and BP. Inhibits hypersensitivity reactions. Therapeutic Class Antiasthmatic, bronchodilator, vasopressor Pharmacologic Class Adrenergic agonist Nursing Considerations • Side effects include: angina, tachycardia, hypertension, restlessness, nervousness, hyperglycemia • Use with MAOI may lead to hypertensive crisis • Patients should not use stimulants (caffeine, guarana, etc) • Excessive use may cause bronchospasm • Assess lung sounds, pulse, BP, and other hemodynamic parameters • Monitor for chest pain • Instruct patient to use as directed • Patient should insure adequate fluid intake to liquefy secretions • Mouth should be rinsed after inhalation • Beta blockers may negate effects • May increase blood glucose levels
Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name Buspirone Trade Name Buspar Indication Management of anxiety Action Relieves anxiety by binding to dopamine and serotonin receptors Therapeutic Class Antianxiety Pharmacologic Class Azapirone Nursing Considerations • Do not administer concurrently with MAOI or grapefruit juice • May lead to dizziness, drowsiness, fatigue, and weakness • Patient may experience chest pain, palpitations, tachycardia • Instruct patient to take as directed • Instruct patient to avoid alcohol and other CNS depressants
Continuing Medical Education Topics from East Carolina University
This is the 2nd podcast episode for the Psychiatric Medication Podcast Series. Series Description: Current literature indicates that podcasts can be an effective educational format to reach health professionals across the continuum of medical education, addressing a myriad of topics pertinent to providers. This episode serves as an overview of MAOI antidepressant therapies. This podcast season is the second released by East Carolina University's Office of Continuing Medical Education and may be beneficial for physicians, residents, fellows, nurse practitioners, physician assistants, and nurses. This podcast season is comprised of approximately 30 episodes, each focusing on different psychiatric medications for the non-psychiatric provider. Those tuning into the podcast's second season will receive a primer on the "bread and butter" behavioral health medications for primary care: antidepressants, antipsychotics, and mood stabilizers. Episodes will be released weekly on Wednesdays.Michael Lang, MD, FACP, DFAPA & Monica Sharma, MD
Trade – ApresolineClass – Vasodilator MOA – Directly dilates peripheral blood vesselsIndication – HTN associated with preeclampsia and eclampsia, HTN crisis Contraindication – Patients taking diazoxide or MAOI's, coronary artery disease, stroke, angina, dissecting aortic aneurism, mitral valve and rheumatic heart disease. Side effects – Headache, angina, flushing, palpitations, reflex tachycardia, anorexia, N/V, diarrhea, hypotension, syncope, peripheral vasodilation, peripheral edema, fluid retention, pareshesias. DosingPreeclampsia and eclampsia: Adult : 5-10mg IV repeat every 20-30mins until Systolic pressure of 90-105mmhgAcute HTN ( not associated with preeclampsia ) Adult :10-20mg IV/IM Pedi : 1mo – 12yr 0.1-0.2 mg/kg IV/IM max 20mg per dose
Download the cheat: https://bit.ly/50-meds View the lesson: https://bit.ly/HydromorphoneDilaudidNursingConsiderations Generic Name hydromorphone Trade Name Dilaudid Indication moderate to severe pain Action alters the perception and reaction to pain by binding to opiate receptors in the CNS, also suppresses the cough reflex Therapeutic Class Opioid Analgesic, allergy, cold and cough remedies, antitussive Pharmacologic Class opioid agonist Nursing Considerations • Assess BP, respirations, and pulse before and during administration – medication causes general CNS depression • Narcan (nalaxone) is the antidote for overdose • use caution with concurrent use of MAOI – avoid use within 14 days of each other • may be used as an antitussive • advised to dilute with NS prior to administration and to administer slowly to decrease CNS depression
You will never hear of DMT being used in this way. We aren't talking about machine elves or blasting off but simply allowing the molecule to suspend your disbelief long enough to see how powerful you truly are. DMT when used in a sub breakthrough manner is very effective in reprogramming the mind, understanding how you create your reality and interrupting negative thought loops. If you haven't heard of Changa - Changa is DMT and an MAOI inhibitor, which when smoked, extends the duration of the experience about twice as long. In this episode my mentor Eve and I discuss DMT training and how we help people to deconstruct their reality. This is the future. Support the show
Download the cheat: https://bit.ly/50-meds View the lesson: https://bit.ly/EpinephrineEpiPenNursingConsiderations Generic Name Epinephrine Trade Name Adrenalin, EpiPen Indication Asthma and COPD exacerbations, allergic reactions, cardiac arrest, anesthesia adjunct Action Affects both beta1 and beta2 also has alpha agonist properties resulting in bron- chodilation and increases in HR and BP. Inhibits hypersensitivity reactions. Therapeutic Class Antiasthmatic, bronchodilator, vasopressor Pharmacologic Class Adrenergic agonist Nursing Considerations • Side effects include: angina, tachycardia, hypertension, restlessness, nervousness, hyperglycemia • Use with MAOI may lead to hypertensive crisis • Patients should not use stimulants (caffeine, guarana, etc) • Excessive use may cause bronchospasm • Assess lung sounds, pulse, BP, and other hemodynamic parameters • Monitor for chest pain • Instruct patient to use as directed • Patient should insure adequate fluid intake to liquefy secretions • Mouth should be rinsed after inhalation • Beta blockers may negate effects • May increase blood glucose levels
Download the cheat: https://bit.ly/50-meds View the lesson: https://bit.ly/BuspironeBusparNursingConsiderations Generic Name Buspirone Trade Name Buspar Indication Management of anxiety Action Relieves anxiety by binding to dopamine and serotonin receptors Therapeutic Class Antianxiety Pharmacologic Class Azapirone Nursing Considerations • Do not administer concurrently with MAOI or grapefruit juice • May lead to dizziness, drowsiness, fatigue, and weakness • Patient may experience chest pain, palpitations, tachycardia • Instruct patient to take as directed • Instruct patient to avoid alcohol and other CNS depressantss
psychology is a part of behavioral science with numerous empirical scientific researches and statistical data about the antipsychotic biological roots of disorders and behaviors, environmental causes of behaviors, important theories of behaviors, behavior treatments, and the efficacy and effectiveness of the antipsychotic medications, atypical drugs, tricyclic meds, and the MAOI medications.
When my dear friend Cat said she would be traveling through our home town of Samara, shortly after sitting in ceremony with Ayahuasca, I jumped at the opportunity to invite her onto the podcast to debrief and share her story. Cat shares her beautiful healing journey, how she reclaiming the relationship with her body, and a vision of the dream she is calling into this world. For those less familiar, Ayahuasca is an ancient psychoactive brew that has been used for at least 1,000 years by the native people of Central and South America. It's brewed by using a combination of two different plants: Chacruna, which contains DMT, and the Caapi vine, which contains the MAOI inhibitors, allowing the DMT to have a lasting effect when consumed orally. Ayahuasca is typically experienced in a ceremonial setting, with a Shaman to hold space, and move the energetic flows. While Ayahusca, or psychedelics in general, isn't for everyone, it can be a powerful tool on the spiritual journey, that can help heal deeply stored trauma, and allow us to establish a deeper connection with the divine. Before Davina and I sat in our first ceremony in November 2020, we became fascinated with hearing other people's stories. There was something truly magical about them, that made us believe that there is so much more to being human, and where we come from. We have yet to share the entire thing, but I promise it's in the schedule for the podcast! As something that deeply resonates for me, I hope to make this into an ongoing series that will be part of the Journey Podcast. I hope you enjoy this first Ayahusca Story! --- Connect with Cat: IG: http://instagram.com/catnisscaro Web: https://linktr.ee/becomingwhoineeded
Anxiety and Genetics Show Summary Today Dr. Rosario talks about anxiety and how it can be linked to some specific genetic variants, as well as what you can do to help support your system and minimize your anxiety regardless of these variants. You will learn the role that MAOI, COMT, and GAD enzymes play in anxiety, how nutrition comes into play, and tips for what you can do to help these enzymes function as they should. She also touches on the role that stress plays in anxiety, how estrogen can also be involved, and nutritional deficiencies that could be making your anxiety worse. If you have anxiety, genetics and nutrition could be making it worse, but there are things you can do to combat their effects. Listen to Podcast Episode # 16 HERE Guide to Choosing Nutrients for Optimal Health Results I've created a downloadable guide “Choosing Nutrients for Optimal Health” to help you choose the right forms of B vitamins and Magnesium supplements for your health needs. Everything discussed in this podcast is included in this easy to read guide. Click here to grab the guide now. Click here to learn more about the Nourished Rhythms Membership.
We witness probably the best sunrise that we have ever witnessed along with learning more about Maoi, Ahu's, and island life. Santiago awaits….. ABOUT THE HOST Rob Smallbone the host of The Property Nomads Podcast, is on a global mission to guide your success. Success can happen in many ways, shapes, and forms. Think about what success means to you. More properties? More clients? Financial freedom? Time freedom? Rob wants to make a huge difference to people around the world. He is here to guide your success in property, business, and life and to inspire you to achieve your goals, dreams, and visions. He's travelled, explored, and invested. And he's not planning on stopping these activities anytime soon. Buckle up, sit tight, and enjoy the ride that is life. BOOKS Buy To Let: How to Get Started = https://amzn.to/3genjle 101 Top Property Tips = https://amzn.to/2NxuAQL WEBSITE www.tpnpodcast.com SHOP www.tpnpodcast.com/shop SOCIAL MEDIA Instagram - https://www.instagram.com/thepropertynomadspodcast/ Facebook - https://www.facebook.com/ThePropertyNomadsPodcast YouTube - https://www.youtube.com/channel/UCejNnh8OEUXSrdgFDFraWxg PODCAST The Property Nomads Podcast: I-Tunes = apple.co/3bHNn5G Stitcher = bit.ly/3cFQVqe Spotify = spoti.fi/2XaZliP See omnystudio.com/listener for privacy information.
Why was the Philippines uniquely primed for the rapid and widespread adoption of Axie Infinity and other crypto opportunities?This episode is sponsored by Quantstamp and Nexo.io.Joining “Money Reimagined” hosts Michael Casey and Sheila Warren are Maoi Arroyo, serial entrepreneur and founder of Ignite Impact Fund, the first fund focused on eradicating income and access poverty in the Philippines, and Leah Callon-Butler, director of Emfarsis and screenwriter of the recent “Play to Earn” documentary. Maoi and Callon-Butler bring a depth of understanding of the economic, political and social context of the Philippines and the recent Axie Infinity phenomenon that swept the nation.The island nation is heavily dependent on its Overseas Filipino Workers, whose U.S.-based workers sent a combined $12 billion dollars in cash remittances back in 2020 alone. The country also faces extensive corruption dating back to the Spanish colonial administration. The low trust of Filipinos in the national economy have pushed them to innovate new ways to interact with money.Over the summer, the play-to-earn game Axie Infinity exploded in popularity, with a significant portion of its user base hailing from the Philippines. Many Filipinos recognized the opportunities abound within the play to earn economy, and more broadly with digital payment solutions and blockchain technology. What will this ambitious, mobile-native population adopt next?This episode was produced by Michele Musso and Adam B. Levine, with editing by Jonas. This episode was announced by Adam B. Levine with additional support by Eleanor Pahl. Our theme song is “Shepard.”-Quantstamp is the leader of blockchain security, having secured over 100 billion USD worth of digital assets. Visit quantstamp.com to learn why top DeFi projects like Maker, Compound and BarnBridge trust Quantstamp to secure the financial infrastructure of tomorrow. Learn more at quantstamp.com/blog.-Nexo is a powerful, all-in-one crypto platform where you can securely store your assets. Invest, borrow, exchange and earn up to 12% APR on Bitcoin and 20+ other top coins. Insured for $375M and audited in real-time by Armanino, Nexo is rated excellent on Trustpilot. Get started today at nexo.io.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Why was the Philippines uniquely primed for the rapid and widespread adoption of Axie Infinity and other crypto opportunities?This episode is sponsored by Quantstamp and Nexo.io.Joining “Money Reimagined” hosts Michael Casey and Sheila Warren are Maoi Arroyo, serial entrepreneur and founder of Ignite Impact Fund, the first fund focused on eradicating income and access poverty in the Philippines, and Leah Callon-Butler, director of Emfarsis and screenwriter of the recent “Play to Earn” documentary. Maoi and Callon-Butler bring a depth of understanding of the economic, political and social context of the Philippines and the recent Axie Infinity phenomenon that swept the nation.The island nation is heavily dependent on its Overseas Filipino Workers, whose U.S.-based workers sent a combined $12 billion dollars in cash remittances back in 2020 alone. The country also faces extensive corruption dating back to the Spanish colonial administration. The low trust of Filipinos in the national economy have pushed them to innovate new ways to interact with money.Over the summer, the play-to-earn game Axie Infinity exploded in popularity, with a significant portion of its user base hailing from the Philippines. Many Filipinos recognized the opportunities abound within the play to earn economy, and more broadly with digital payment solutions and blockchain technology. What will this ambitious, mobile-native population adopt next?This episode was produced by Michele Musso and Adam B. Levine, with editing by Jonas. This episode was announced by Adam B. Levine with additional support by Eleanor Pahl. Our theme song is “Shepard.”-Quantstamp is the leader of blockchain security, having secured over 100 billion USD worth of digital assets. Visit quantstamp.com to learn why top DeFi projects like Maker, Compound and BarnBridge trust Quantstamp to secure the financial infrastructure of tomorrow. Learn more at quantstamp.com/blog.-Nexo is a powerful, all-in-one crypto platform where you can securely store your assets. Invest, borrow, exchange and earn up to 12% APR on Bitcoin and 20+ other top coins. Insured for $375M and audited in real-time by Armanino, Nexo is rated excellent on Trustpilot. Get started today at nexo.io.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Get Your Tickets for the 1st Oakland Psychedelic Conference: https://www.eventbrite.com/e/oakland-psychedelic-conference-tickets-169188460239?ref=eios Today on the Mushroom Hour Podcast we are beyond blessed to be joined by three members of Oakland's own Hyphae Labs, Ian Bollinger, Tomás Garret and Reggie who has joined us on the podcast previously. Inspired by early-life transformative experiences with psilocybin-containing mushrooms, Reggie has had a lifelong passion for mycology and now consults with the largest mushroom cultivators in the world. He is a also member of the Advisory Board for Decriminalize Nature and an avid activist for police reform and an ally of The Movement for Black LivesIan Bollinger is a dedicated researcher, scientist and host of the Understanding Entheogens Podcast. Advising for harm reduction through education by working with the entheogen decriminalization movement in the SF Bay Area; Ian dedicates his time to churches, non-profits, and public benefit corporations to bring scientific insights from the growing entheogen space to the public through his writings, podcast, and outreachTomás is the head of operations for Hyphae Labs. His background is in analytical chemistry that began with food and drug testing in Wisconsin. He moved to California in 2018 and began pesticide and solvent testing for the cannabis industry. Over the past few years he has become intertwined like mycelium with the vibrant Oakland psychedelic community.Formed by citizen scientists like these, Hyphae Labs works to connect cultivators and consumers to knowledge, data, and education that supports their community through harm reduction. They are currently engaged with research around Tryptamine content in entheogenic organisms, providing lab and analytical support for the Psilocybin Cup. I am excited to learn more about their collective, their vision and the upcoming Oakland Psychedelic Conference. TOPICS COVERED: Hyphae Connection Between Ian, Tomás and Reggie Mission and Purpose of Hyphae LabsWhy is Testing Entheogenic Compounds Important?Testing Compounds in Psilocybin-Containing Mushrooms Legality of Testing Entheogens in Oakland Connection Between Testing & Decriminalization Wading into the Chemistry of Tryptamines MAOIs in Mushrooms Effects of Compounds Other than Psilocybin The Hyphae Potency Spectrum Inspiration & Goals of the Oakland Psychedelic Conference Featured Speakers at the Conference Building Community & Embracing Diversity Future of Hyphae Labs as Psychedelics Go Mainstream EPISODE RESOURCES: Tickets for Oakland Psychedelic Conference: https://www.eventbrite.com/e/oakland-psychedelic-conference-tickets-169188460239?ref=eios Oakland Hyphae: https://www.oaklandhyphae510.com/ Oakland Hyphae IG: https://www.instagram.com/oakland_hyphae/ Ian Bollinger IG: https://www.instagram.com/eyepsychonaut/ Understanding Entheogens with Ian Bollinger: https://www.critical.consulting/blog Dictyonema (Fungus/Lichen): https://en.wikipedia.org/wiki/Dictyonema
🎶 u may tire of me 🎶 // 🎶 as our december sun is setting 🎶 // 🎶 ‘cause i'm not who i used 2 be 🎶 summer break is over and M&M is back! welcome babies!!!!!!!!!!!!!!!!!!!!!!Sigmund leads today on the unfortunate death of Libby Zion - a famous case that most docs and many people in healthcare have at least heard of - and how it eventually led to changes in physician residency training. work responsibilities limited to 24 consecutive hours (with caveats), 80hrs/week (with caveats), and a mandatory 10 hours rest period in between clinical duties, among other things; while this is progress from the more horrific exploits of residency prior to these changes - 120 hour weeks, q3day 36hr in-house call - we have to ask: how far have we really come? many residents still routinely lie about their duty hours. mental health continues to deteriorate for residents and even beyond residency; attending doctors face ever-escalating production pressures (employers increasing the relative rate of surplus value), documentation burden merely for billing purposes, and cost-saving mechanisms stemming from the 1980s neoliberal political turn and the managed care regime. the questions we all need to start asking are: how do we get closer to making a lasting, positive transformation in how young doctors train? and how will that set us up for a future of meaningful labor - and importantly - on our own terms?music:intro - created by fidel cashthoclosing track - my sweet lord by george harrison This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.marxismandmedicine.com
“New Frontiers of Psychedelics” with Tania de Jong [00:00:00] Hey and welcome to this week's episode of Perspectives I am your host Sharon Pearson, and we are joined today by an extraordinary guest who has done some remarkable work in a field that is maybe to some of us, a little left of center. Her name is Tania de Jong and she is the founder and executive director of Mind Medicine Australia.And she has done some phenomenal work in moving forward, ensuring that some psychedelics and MDMA may becomes legalized within Australia for therapeutic purposes. This is a topic that I find truly fascinating, Tania is executive director and co-founder and board director of Mind Medicine Australia. And it is a registered charity acting as a central node for regulatory approved and research.[00:01:00] Psychedelics. She is identified in the psychedelic invest top 100 influential people in psychedelics, and she became interested in the resurgence in psychedelic research field after searching for ways to manage your own mental health and her own wellbeing. And we talk about this in the episode, she explains and walks us through her first psychedelic experience and how it transformed her with the support of her partner, Peter, she set out on a quest to have a therapeutic experience, but being able to do this in a safe and legal setting, which as you probably know around the world, isn't that easy to accomplish, have to experiencing this life-changing experience.She realized the potential of these medicines and she very clearly and distinctly calls them a medicines, not an illegal substance. And she also makes it clear here that MDMA and the psychedelics we talk about are not addictive, despite what we may have heard in the moral panic that can be attached to conversations like this.So she's on a mission to help [00:02:00] alleviate the suffering caused by mental illness in Australia that she truly believes is not necessary. And when you hear us have this conversation and you hear about the stats and what's been achieved in clinical trials around the world, right now, there are over a hundred clinical trials taking place around the world, including at John Hopkins, one of the most renowned research facilities in the world.And when you hear these results and we'll include in the show notes, links for you to get more information and maybe to some research as well. So you can see for yourself how profound an impact. that these medicines combined with therapy can have on people who are suffering from PTSD, depression, anxiety, even eating disorders.It is, mind-blowing what I've been learning. She also is part of my Mind Medicine Australia helps to and has phenomenal facilitators, helping to train the facilitators of tomorrow, the psychiatrists and psychologists and the therapists who will, when this becomes legislated within Australia [00:03:00] guide people who want to experience a transformation from the depression or their anxiety or their PTSD, and the team is training them entire process of how you can go through this therapeutic process.This is not an advocacy program for taking drugs. illegally is not an advocacy program for going to a rave, getting smashed and not drinking water and becoming a statistic. This is a conversation based on current research in 2021, and it is really exciting what the future holds. It's so great that you're joining us today.Tania thank you so much. I'd love for you to share with our audience a little bit about your journey as to how you got here to having that as your backdrop, Mind Medicine Australia, if you would please. Sure. Look that's a really long story, but I mean to cut a long story short well my drug of choice has always been singing.So I have always [00:04:00] loved singing and it's been a wonderful form of meditation relaxation. There'll be entertainment connection, so many things for me. therapy so I've never felt the need to have any drugs of any kind. And I've never, in fact, I've always been quite anti-drugs. And so it is, it is surprising that I do have this as my backdrop, but I guess to cut a long story short, you know, I'm the daughter and granddaughter of Holocaust survivors.My grandmother invented the foldable umbrella in Vienna in 1929. So you know, innovation is very much in my blood and I have founded two previous charities to Mind Medicine Australia, plus about six other creative businesses as well. And I've been a performer before, you know, all of, all of my sort of adult life, even though I was told, never double that having singing lessons at the age of 14 and.But I also, I did a law [00:05:00] degree and I've always been extremely entrepreneurial. And so, you know, I sort of, I guess, become the serial entrepreneur and as I've evolved and growing I become interested in different things and there's just sort of been this yeah, I mean to where I am today, where I'm, you know, a co-founder and executive director of Mind Medicine Australia, and those still you know, I'm very passionate about my work as both a performer singer and speaker, and some of the work that I do for collective healing.A lot of the event production work I do as well is tied in to this. So in a sense, it's bringing together a whole lot of different things that I do. But Mind Medicine Australia is, is certainly all consuming. Like it's taking a lot of time up for me and my husband. We do this pro bono and we also do, that's the question I get that you do all these other things, [00:06:00] but why that is the backdrop, that's what I'm interested in.How did you arrive at a place where make getting, helping and facilitating the movement for psychedelics to become legal for medicine? Or how did that happen? Yeah, so that really happened because I've always been interested in hacking myself. So, you know, I've, I've tried lots and lots of different things, different dietsyou know, I tantra mantra cryotherapy my therapy, you know, hyperbaric oxygen all sorts of different retreats, relationship, work personal development. And physical sort of stamina sort of modalities that I've always been really interested in. And I never heard about psychedelic assisted therapies until about five and a half years ago.When I read a blog of Tim Ferriss, who's one of the great donors and investors in this field and he announced that he was donating a [00:07:00] hundred thousand US dollars to impure colleagues to trial of psilocybin assisted therapy to treat depression. I'm not, I don't suffer from depression myself, but I certainly know a lot of people who are suffering with depression.I've worked with a lot of people who are suffering with depression. And so I clicked on the link was to an article by Michael Pollan in the New Yorker magazine called the Trip Treatment and I read this article and it was about, in fact, profiling, a Jewish man who was going to an end of life, probably had a terminal diagnosis, but he had been experiencing, I think, some transgenerational trauma.And I had also. Being experiencing that I didn't really know what it was. You know, I'd have some strange dreams from time to time where maybe I was, and this was awful, you know, where I standing in front of a Nazi firing squad and things like that. And I'm thinking, well, where is this coming from? You know, this is, [00:08:00] I wasn't there for that.And so I felt that there was, you know, parts of my psyche, I guess, that were still carrying some of this ancestral trauma. And so when I read, you know, about this guy's sort of remission conditions and things, I thought, all this sounds amazing, you know, like amazing. And so I said to my husband read this article, I think we should, don't do this treatment.Hey, read it. And he said, oh, you know, it sounds interesting, but he didn't take any more interested in it, but he said, well, if you want to organize it, just go ahead. And he generally does say that about a lot of things. And so I then reached out to Dr. Robin Carhart Harris. Who's one of the leading researchers in this field who was mentioned in the article and asked him if there were any healthy patients trials that we could participate in because we don't have a mental illness diagnosis, but there weren't any taking place in the, in, in Europe at the time.And so we were eventually referred to a [00:09:00] guide in the Netherlands and we then flew to the Netherlands where we worked with that guide and had a massive medicinal dose of psilocybin yeah, I've been pure psilocybin, which was preceded by Syrian Rue, which is a MAOI inhibitor. So the protocol was called silhouette, Cisco, which was a combination really of psilocybin and some of the effective well scope because of the Mio inhibitor Syrian ruined.This was. A huge experience. Like we were literally shot out of our bodies into other dimensions, into the multi-verse you know, journeys, this journey that we went on. And of course our journeys were entirely different. Peter's his father had committed suicide when he was thirteen also. So, wow. You know, we all carry trauma either directly or indirectly.I think we're all carrying a lot of angst and grief along with us. And particularly now I've never felt so much [00:10:00] that way, carrying as a, as a collective and disconnected and huge disconnection and, you know, wonderful thing about these medicines is the enormous sense of connectivity that they bring, you know, the sense of being connected to yourself, to others, to the planet.I really is very profound and the healing that waits. Was enormous. And it's not that we were really ill or that we weren't not functioning or anything like that, but we became much better functioning. You know, I thought I was creative before, but you know, like I've been able to join the dots and understand things that I previously was not able to understand as well.Yeah, it's, it's really a profound effect. And it's improved our relationship, enormously, our relationships without families colleagues I think we've become, you know, more grounded more authentic is less ego in the way because I experienced and we both experienced like [00:11:00] play ego dissolution.So if I may, what that was like was when I taken the medicine. And I deliberately call these medicines cause that's what they are. These are ancient medicines. You know, they've been with humans since beginning of civilization and you can see the history of these medicines in ancient, Greek, and Roman cultures in the archeology.You can see the mushrooms and things like that. Ancient drinks like Kiki on that were taken to alter people, states to, to take them into these, these little ordinary states and. They've been in indigenous cultures since the very beginning. And they still are, of course being used in indigenous cultures completely legally in Mexico, south America.I mean, these medicines are illegal in the Netherlands and no range of other places. It just seems so ridiculous to me that, you know, you can go out into your garden or a field, and there's all these [00:12:00] psilocybin mushrooms, which contain the mind altering substance. And yet if you eat that mushroom, if you pick it and eat that mushroom, then that's, you know, it could end up with you being prosecuted and put in jail or whatever completely ridiculous when you actually go into your garden and pick a poisonous mushroom and eat it and die.Whereas you could eat these mushrooms and completely be healed of many of, you know, the things that we're struggling with in suffering within this human Carnation that went, that we're in. So yeah, it was, it was Extremely profound experience. We came out of it saying that not only was it incredible for us, but that will set up for charities between us before Mind Medicine Australia.And both of us just said, well, you know, you can provide housing. You know, my husband's a [00:13:00] founder of women's community shelters I'm the founder of the Song Room and Creativity Australia, and that with One Voice program to provide creative programs, wonderful social inclusion applies, you know, you can provide all these things to people who are suffering disadvantage of some kind or another, whether it's homelessness, unemployment, disability, whatever it is to be, you know, feeling older and more isolated.But the fact is if a person has a mental illness, Of some kind that there's some sense of anxious, depression, whatever it happens to be trauma that they carrying along with them. If you cannot get to the root of that trauma, it doesn't matter what else you give them, because actually they're not going to feel better and they're not going to be able to lead a fully meaningful and contributing life.And imagine if that's a gift that we can give to people that they can feel, you know, connected and, and more whole more of themselves. If that's a gift [00:14:00] we can give people, then we should give that to people. And we shouldn't withhold it from particularly from people who are suffering. But of course we shouldn't withhold it from anyone because it's our birthright.These plants are on this planet for a reason. They are a medicine they contribute to our wellbeing, our sense of wholeness, oneness unity with, you know, self and others. I mean, how could we deny people the experience. Traveling into altered dimensions and experiencing the 95% of life that we actually don't say on the daily basis, we started really, after that first experience, meeting a load of the researchers reading a lot of the trials that were going on and familiarizing ourselves with the space.Then we started going to conferences and events around the world. A year later, we did another ceremony experience, I guess, with the same guide and it was even more profound. And then we were just completely [00:15:00] convinced. We were just like, well, everyone needs to have access to these medicines who needs access to them.And we also looked at what was not going on in Australia. Really. There was very little going on in Australia. There were, you know, an amateur psychedelic society. And that sort of thing, but there was, you know, a tiny handful of researchers who were interested in this space, but there was really nothing.We had nothing to offer. We were acting in Australia, like it was 1970 and Nixon had just declared war on drugs. I was thinking in Australia for so long. Yeah. It's out of date by 50 years. So, and now there is research in Australia because the thinking around this is come full circle. So thank you. I'd love to just add a little disclaimer here.I have a little caveat for anyone listening, who perhaps is still perhaps thinking the way I used to think, Tania so this is for anybody who's thinking [00:16:00] like I used to think this is not us advocating, taking any drug. However you want. We are not advocating use of drugs that you buy off the street. We're not suggesting that we be irresponsible with what we have in your conversation about.Is using psychedelics something like perhaps MDMI, which is a different category of therapeutic medicine or a psychedelic like psilocybin for therapeutic purposes to help in the healing process. Ideally with a trained therapist, who's trained in how to guide you through a really extensive process, because I've now watched the movie.You, you had on that around the Israel study that was done, and I'm familiar with a number of the protocols now and how to help someone resolve trauma and the kind of stats these results are producing. So I invite you if you're an audience member thinking I never want my kids to do drugs. We are not advocating your kids do drugs.I mean, I think it's important also to say to everyone who watches listens to this [00:17:00] is that everything is about the context. Everything is about the context in which a medicine or drug is used. So, you know, morphine, which is. Used often in the hospital, but you know, if you take it recreational it's, it's no good heroin on the street is no good, but it's using the anesthetics when you go and have an operation in the hospital.So everything is about your intention and how you use that medicine in an intentional way for healing or whether you're using it just to get off your face because you can't deal with your trauma. It's leading you to become an addict, an addict in something else. It's important though, to say that these medicines are extremely safe and non-addictive even in recreational environments, they considered to MDMA particularly and psilocybin in their pure GMP pay grade form are considered extremely safe in recreational environments[00:18:00] whereas alcohol is by far the most dangerous drug to self and others. And that's been proven in multiple trials and studies around the world. So. We are talking about medicines that when used intentionally under the guidance of, you know, a supervise guide or therapist can truly transform your perspective on life and certainly create enormous healing for a range of conditions, not only including depression and anxiety and trauma, but are now being trialed for addiction.And they, the, the results for treating addiction the results are incredible yeah. End of life, anxiety, obsessive compulsive disorder, anorexia and eating disorders. Alzheimer's now cluster headaches and of course, PTSD and so we're seeing these medicines now being trialed for. An enormous variety of conditions.And my [00:19:00] belief is that they will be trialed for even a broader group of conditions as time goes on, because the way that they reconnect brains on neural pathways is so significant that that, and that sense of connectivity is so important to a person's healing. And really these medicines help to empower us, to become agents for our own healing, rather than taking daily pills or relying on a psychotherapist for the rest of our lives.And this is nothing against the wonderful psychotherapies that are there. It's simply saying that there are treatments and with two to three medicinal treatments combined with a short course of psychotherapy, 60 to 80% of patients across 160 recent trials are going to remission. Now you compare that again.30 to 35% remission rates from current treatments for depression, or just 5% remission rates for [00:20:00] post-traumatic stress disorder. And it comes back and if they suspend treatment, it returns. Yeah. And let alone all the side effects and the withdrawal comes through these medications and so on. So in this case, we're saying that mental illness does not have to bail.I said that there is a cure for many patients available, not for all. This is not a panacea for all. And nor are we saying that current existing treatments don't work for some patients, they do. They just don't work for the majority of patients. And we have a mental health crisis. And this is one of the reasons why Peter and I, as philanthropists and social entrepreneurs are putting all our money and time, energy into these, because the impact.It's enormous. The potential impact is huge. Like Mind Medicine Australia, and other organizations, like it, have the potential to change and save the lives of millions of people yeah, who was suffering - there is 1 million [00:21:00] soldiers in the us, struggling with PTSD as we speak and traditional old school therapies are not resolving it, but the results they're having five years later, 53 to 50%, 7% of them have cannot any longer be classed as having PTSD.Yeah. In the recent phase three trial of MAPS with both veterans, first responders and also others suffering with post-traumatic stress disorder straight after just three medicinal doses of MDMA with a short course of psychotherapy. 67% of those patients have gone into remission. And it's expected that as they integrate the experience, it's important to say psychedelic assisted psychotherapy means the medicine, the psychedelic with the psychotherapy, the medicine on its own.It's not going to be fully effective. Anyone out there. I just say that as a word of caution, that you need to do a proper integration process because the insights that [00:22:00] you will experience using these medicines are profound, but to capture them and bring them into your lives, your relationship, relationships, your work, whatever you need to bring them into all elements of your life takes integration.It takes work with a therapist to bring those learnings in and to then make the changes that you need to make in your life that are going to relieve some of the suffering and, and help you to experience what is really here, this beautiful life that we've been gifted by our parents. It's just such a gift.And it's, it's a terrible tragedy that most people can experience, I guess. That you know, and this is really, really the reason why we set up Mind Medicine in Australia is because we have this mental health epidemic in Australia and globally that is, is just getting worse and worse. You know, pre COVID in Australia alone.We had one in five Australians with a mental illness, one [00:23:00] in age being prescribed antidepressants, but one in four older adults and one in 30 children, as young as four. Now that is a terrible indictment. You know, we are over prescribing these medications more than just about any other OECD patient. And furthermore, you know, what we're seeing is that, you know, these statistics suggest that one in two of us will suffer a mental illness in our lifetimes.And we can't continue to overmedicate people in the way. Is occurring at the moment. Well, the medication is suppressing a symptom, whereas the therapies that are now on, in studies around the world, a lot of studies in the world are dealing with the core of it and resolving the core issue. So the symptoms will, I'm no longer required.There's one story I heard about, I think I'm going to attribute it to Rick Doblin, who is one of the major leaders in the world in this research. I know you have a relationship with him. I think [00:24:00] it was him. I'll give him credit for it. My apologies if it isn't him, whoever that is. And he said one of the first experiences of it was a soldier who experienced PTSD and had for years, 17 years, I think it was.And he held onto the PTSD. He realized this when he was taken through the therapeutic process and on his very first trip, I think it was MDMA but I can't remember if it was psilocybin he came to realize that he was staying in stress to honor his dead comrades. I'm going to get emotional.And only in that very first trip, you mean the requirement is you have therapy, then you have a trip, some therapy trip therapy, trip, some therapy at the end. So it's three trips with therapy back-to-back he did the pre therapy, did this one trip and realized the only reason he held onto his honor is dead comrades Chrome rights.As a result of the psilocybin, he became his dead comrades and saw his life through their eyes. And in the moment of seeing his life through their eyes, he realized they'd never want [00:25:00] that for him. He dropped out of that very first study and years later, any symptoms of PTSD are completely resolved and now he works assisted.People experiencing trauma. And that's just to correct you by the way. I think that person who is MDMA therapy, not psilocybin thank you. Thank you. Thank you. Thank you. Assisted therapy is the one that's used for post-traumatic stress disorder, psilocybin therapy therapies used for depression and development as well, so perfect.And they were able to drop out of the study. And so I don't need, there is the trips aren't needed the therapy and they've had years of therapy and putting aside whatever issues we have around this, let's pause and take in this. What looks like in any other category, if it wasn't criminalized, we would consider miraculous and worth pursuing with all our mightthe world would be transformed if it was doing this for anything else that had [00:26:00] illegal substance around. Totally. That is a transformation. Their life is changed and saved because of this. Let's pause and think, well, maybe we need to change our views of it. Our preconceptions that come from the 1970s or late sixties and realize what's shifted in the world now, which I love.I love the shift. Well, absolutely. I couldn't agree more. And you know, if you think about it, that the existing treatments, most of them are based on science that is over 50 years old. I mean, in what other field of medicine are we so stuck in the past and why are we running towards these treatments? You know, so the Brigadier general of the veterans in, in the U S said, you know, based on the data and facts, we should be running towards these trends.If this could even save a handful of lives, but it can save literally. Millions of lives. So why aren't we doing that? I think it's turning now. So let's just take a moment and talk. It was [00:27:00] really bad in the sixties. So one of the lines, I think Rick said, but again, I think I'm giving him a bit too much credit.I think it was Griffiths said in the 1960. So it was used in a lot of clinical trials back then, as you know, Tania it escaped over the laboratory wall and made it out into the counterculture and the counterculture getting hold of it meant that the, all the negative stories in the myths began to be produced around the world.That's how we heard these stories about if you took it, you would stare at the sun until you went blind. It's a complete myth and a lie that was created to create fear amongst it, which forced it way underground for way too long. But we're talking today because that landscape is no longer the landscape we find ourselves in.Absolutely. And, you know, it's interesting. So even though I didn't know what psyilocibin was, and I didn't even really know what psychedelics were, to be honest. When I did this, there was still, obviously some of those messages that stigma was flying away because I wasn't even aware that I had it, but I was like, am I going to go crazy?Am I going to have a heart attack? Is, you [00:28:00] know, so they, you know, they sort of, these myths are very strong. And so one of the really important roles of mine medicine Australia is to actually dispel those myths and to focus on the science and the data. Because when we focus on the funds and data, it's absolutely clear, like, you know, the risks attached to these medicines are actually extremely low.There has not been a single adverse event with thousands of patients. Who've undergone either psilocybin or MDMA sister therapy. Over 160 trials, you know, no one has become a drug addict before because of them. In fact, many drug addicts and smoking addict addicts smokers have, have actually been able to like their addictions have gone because of these treatments.So yeah, it's, it's really yeah, it's amazing how we, we sort of turned things upside down didn't we, you know, so that alcohol was not made criminal cigarettes were not made criminal [00:29:00] and cocaine and meth amphetamines and all these really dangerous drugs, you know, the people can access very easily and yet yeah.But yes, what is really great is we are seeng this Renaissance now and. It's brand has brain rejuvenated, Tanya. So leading the way, just so we can get some facts out there for people listening. Who've never heard about this Renaissance. That's been going on. John Hopkins has been conducting studies for a while.Now. NYU is conducting studies. Studies have now begun in Australia. There's millions of dollars of funding. It's not a lot, but some, but one of the stories I found most interesting was Tim Ferriss was talking last year in 2020, as result of a a citizen philanthropy, there is $30 million in private funds to pursue clinical trial stage three trials.In the effectiveness of psychedelics in therapeutic settings that tells me the tide has [00:30:00] turned on this conversation finally, to enable people who need the help, who are suitable for these types of therapies can get the help. And just to be very conservative, there is complete recognition. Not everybody is suited to this.There are some personality types and some, I think it's remind me, what is it not suited for? So, so at the moment, schizophrenia and bipolar excluded those with incidences of psychosis, but many of the psychiatrists actually believe that over time, as you know, these medicines are studied further, those conditions also be able to be treated.And I do know instances of people who. have been So because they haven't been accepted into the trials because of those conditions have gone underground where they, the borderline of bipolar and other conditions and have actually healed as well. But at the moment they're excluded from the trials and, you know, at time it will just take time.And the more that we invest in you know, research in this space, [00:31:00] but also the more that actual access is granted, so that we can click data as people go through treatments. And that's one of the things we've really fast-tracked in Australia is that these treatments are currently available through special access scheme pathways.And what that means is that a doctoral psychiatrist. You know, it can work with a treatment resistant patients. So a patient who's tried two or more other treatments that haven't worked and who is very ill and potentially could be suicidal, but certainly is very ill. And the doctor and psychiatrist applies to the TJR regulator to treat that patient with either psilocybin or MDMA assisted therapy.And the TGA has been granting those treatments. In fact, I don't believe they've knocked any back since last June, so that's a federal approval, but then the doctor then needs to get an approval in the state to treat the patient. And in some states there are still these recreational use laws that prevent the [00:32:00] medicines from being brought in because they're seen as drugs instead of medicines.So what we need to make sure occurs is that there's a national standardization, a permit system put in place in every state of Australia. That means that doctors can. Bring those medicines in to treat patients in clinical environments, that's completely different to a recreational use setting. And so, you know, again, this comes down to context and unfortunately the states are not making this distinction between the use of the medicine in a medical environment to treat a patient who's really unwell and potentially save their life versus someone who's going underground to access you know, they drugs what's the resistance around it. Given it's moved so far forward in the United States. So in the United States, the FDA has last year declared it for breakthrough status, which means it's a breakthrough. Which is a breakthrough [00:33:00] medicine. And what that means is they give approval to fast-track the different stages of clinical trials that need to occur.So we can start helping people as soon as possible Australia, I, to, to medicine that that could be vastly superior to existing treatments. It's a very good nation. Yes it is. And where are we in Australia? Yeah, so we have the SASB approvals taking place trickling through, but yeah, yeah. We need to get through some of the state barriers, which we're working on, but also in Australia, we've put in submissions for the rescheduling of both MTMA and psilocybin from schedule nine, which is prohibited medicine, which implies it's dangerous and of no benefit, which is completely wrong and is simply based on the politicization of president Nixon in 1970.Yeah. Two schedule eight schedule eight meaning controlled medicines. So that means the medicine would be used in clinical environments under the supervision of trained practitioners. And that's where this medicine [00:34:00] should be sitting if not schedule four. So in Australia, we have a number of medicines and schedule a and schedule four, which are far more dangerous than either psilocybin or MDMA and schedule four schedule four is a more, slightly more accessible, still controlled, but slightly more accessible.But we have medicines like ibogaine, which is used to treat very heavy drug addicts. It's a psychedelic medicine also, but it's far, far more, you know, No potential far more significant effects on the heart and so on. Whereas psilocybin and MDMA do not, as I said before, there's been no adverse events with their use whatsoever.And you know, they continually come up in files, like for example, these a recent trial that has been undertaken in pure college directly comparing an SSRI, an antidepressant with psilocybin [00:35:00] assisted therapy. And in that trial the 60 patients were either given two doses of psilocybin with psychotherapy or a daily dose of a esetelgram which is an antidepressant.And at the end of the trial twice, So twice as many of the patients in the psilocybin group went into remission, as that is to tell a prime group, they also had less side effects and less suicidal ideation. So what we're seeing is that in every single trial, these treatments are showing themselves as to be far more effective and actually safer than existing treatments because yeah, and again, they don't treat the symptoms, they treat the core.It's a long-term resolution, not a suppression. Correct? Correct. And this is all about curative medicines, not just palliative medicine, about, you know, finding a cure so that person can then, you know, become fully aware of what has been their trauma or their challenge. And they can get through it [00:36:00] themselves.Just coming in, obviously with competent therapists is extremely important. It is important to note that a lot of the existing treatments do have negative effects for a lot of people, they can lead to suicidality in some patients and their side effects significant as, as many of us will know. And also it's, it's a known fact that it's extremely difficult to withdraw from antidepressants if you've been on them for, for awhile, and that can create its own problems.So we need to be very careful. And Mind Medicine Australia says, you know, we say six days. As expanding the treatment options available to medical practitioners and their patients ensuring that these treatments become a first-line option. So that if you go to your medical practitioner, they will discuss a range of statements with you disclosing full risks and benefits.One thing we hear about often is that doctors don't fully disclose the, the side effects of antidepressants to their [00:37:00] patients, and that should be happening. You know, we should have full disclosure to all patients, and then it becomes a decision for the doctor and patient as to what's going to be the most effective and safe treatment for that patient on a case by case basis.It's not just this broad brush stroke that everyone who comes in, you know, who's feeling a little bit sad, just gets given an antidepressant script and, you know, success for us. We'll look at, look like first-line treatments. Secondly, that the remission rates are very high. And continue to be very high and that the right treatment protocols are put in place for all patients.And finally that these treatments are accessible and available to all Australians, no matter where they're based, their financial circumstances. So a big part of our focus is setting up this ticket in psychedelic assisted therapies. And we've had our first cohort go through [00:38:00] 46 psychiatrists, psychologists, GPS, physicians, therapists, mental health nurses, social workers, occupational therapists, counselors.And so they've already gone through and many of them have rated the course as the model. Life-changing and important course and the most brilliant training they've ever undertaken. We have a world-class faculty and as our second intake commences, and a couple of weeks and is nearly full. And then we have probably up to four intakes in 2022.The demand is huge. And so this is preparation for what's coming because you anticipate the laws are going to need to start keeping up with all the other research around the world. The research now is reasonably your refutable it's trials have been complete. The stats are in, we can't argue with these ridiculously successful.Absolutely. But also a lot of these therapists are able to start working with patients now, so they can do, you know, they can help prepare patients who are [00:39:00] going underground because it's not illegal to do that. They can provide integration to patients. Who've used the medicine. They could work on trials and they can work with their patients who are getting SASB special access scheme approvals.So in actual fact, the therapists who are being trained and getting the qualification now the front run is in this space and they're the therapists who will gain first access also to be part of, you know, some of the trials and, and other pathways that become available. And St Vincent's has started its own trial.I think last year is that right? They've done. They have some funding for a trial. So we part funded a trial at St. Vincent's, which is for end of life anxiety and stress caused by a terminal diagnosis. That's going through about 30 patients. It's similar to some trials that have been conducted overseas at New York university.And. Johns Hopkins. And [00:40:00] the interesting thing is that the one at New York university, which I mentioned before, which was an inspiration for me in terms of actually trying to spice it up was what was really interesting about that trial was that 80% of the patients went into remission immediately from the end of life, stress and anxiety, and were able to, you know, it continued.But what is remarkable is that after four and a half years, the researchers went back to those patients. And not only were the majority of them still alive, but all of them were still in remission who was still alive. Wow. That's a whole other study. That's a whole different study. That's got to be done.That's staggering. I didn't know that. That's right. Yeah. My mind is blown. That's incredible. We probably should've done this sooner. Would you mind touching base for our audience members? The difference between MDMA whose full name? I cannot pronounce, no matter how much I researched. And let's just talk about psilocybin, which is an [00:41:00] element of magic mushrooms.Can you just share the difference basically between the two? Yeah, so MDMA is known as a empathogen. So basically what he does is it's actually not a traditional psychedelics. So what it does is when you have the MDMA you feel very warm and loving and connected, and unfortunately MDMA has been very vilified because it's been used a lot as a party drug people at music, festivals and so on, but.Young people are getting when they think they're getting MDMA is an adult rated substance. In fact, in a lot of the capsules that people think is MDMA there's other substances and sometimes is no MDMA whatsoever, which is what leads to those headlines, further drug deaths from MDMA which is unfortunately not what's actually happening.And it's also known for the audience. If they haven't heard MDMA ecstasy or Molly, that's the straight kind of name for it. Yeah. [00:42:00] Fortunately ecstasy and Molly have go a bad name because making it at music festivals at rave parties and so on in combination with other substances often with dehydration kids staying up all night and that can lead to really bad effects.But MDMA and it's pure GM P pharmceutical grade. Substance that's used as a medicine and a medically controlled environment creates enormous empathy and trust and safety for the patient, where they are able to talk about their trauma with the therapist in a very safe and loving environment. And what the MDME does is it reduces the activity of their Mikela, which often triggers a fight or flight response.So when a therapist normally gets you to talk about your trauma, that can re trigger a re traumatize, you, which can make you worse in effect, you know, I'm sure we've all spoken to people. Who've suffered with trauma at one time or another way we try to talk about the trauma and they either [00:43:00] burst into floods of tears.race out of the room can become very emotional and it can become very problematic. But what happens with this is the patient's able to talk about their trauma. They're able to accept what has happened and to move forward with their lives. And be healed. And, you know, in the case of the phase two trials with MAPS it 105 patients, all of whom had been suffering with post-traumatic stress disorder for an average of 18 years, just three medicinal treatments.With a short course of psychotherapy, 52% of them went into remission immediately, but 67% after 12 months with full integration. So you can imagine the suffering that they had experienced, then the remission that they achieved. And that's what it, those 5% from existing treatments, how can we not give that gift to people?You know, it's, it's extraordinary. So MDMA provides an incredible therapeutic [00:44:00] window in which competent therapists can work with a patient. I'll just mentioned to the audience for MAPS the multidisciplinary association for psychedelic studies. Yes. And then psilocybin is the psychoactive component of magic mushrooms.It is a traditional psychedelic medicine that has been with humanity since the beginning of human civilization. And what it does in the brain is it's, it helps to bypass. What's called the default mode network of our brain. The default mode network of our brain keeps us stuck in very rigid stuck thought loops, particularly with suffering from depression or anxiety or some form of trauma.You know, I'm not good enough things weren't work out for me. My life is rubbish. No one loves me and I actually share, and I will provide a video that you might like to attach with. Interview [00:45:00] that people can watch that gives some further, further guidance, but the wonderful philosophic is that it it really can expand to what's known as our five T H two-way receptor, which is a serotonin receptor in our brain.And the psilocybin floats beautifully into that receptor and it creates this therapeutic window. So that in effect, what happens is when you take the psilocybin, the default mode network of your brain is sorta goes to sleep and you get the sense of incredible neural connectivity. And I'll provide you with some scans of FMR.I. Yeah, good scans down on some patients with depression that show in the placebo. So for patient with depression, they have very limited neural connectivity. You know, these rigid, stuck thought loops, but with the ingestion of the psilocybin, they experienced this massive neurogenesis, this neural [00:46:00] connectivity where different hemispheres of their brain start reconnecting, they experience increased neuroplasticity, and that allows this connectivity, this sense of oneness to take place.And again, creates a therapeutic window where a competent therapist can work with that patient post the treatment because the patient in the silicide and experience, isn't an entirely altered state. They will usually experience some form of ego dissolution. Yes. And it will no longer be Tania or Sharon.It'll be one. Yes. You're part of everything. Everything feels part of you. It's a wonderful, wonderful feeling. And from that experience, you can then start to come to terms with some of the things that are holding that. Yeah. So in my case, would that look like was I traveled completely out of my body. I actually saw these three boxes that had the word ego in them with a red cross for them.And I kept [00:47:00] saying ego, I please get out of my way, get out of my, go down the drain. And actually below is three boxes where drains, they sewage look like sewage pipes or drains. And I kept trying to push my ego down the drain. That was what symbolism was of what I was saying. Once I had pushed my ego down the drain, I was then able to journey further with my experience where I just became one with everything and everything became a part of me.And if you have the right. dosage of each of the medicine, which you will always have in a medically controlled environment, then you will hopefully inevitably experience that. Now with some people that may take time, you know, if a person has been on antidepressants for a number of years or decades, it may take more experiences with the psilocybin, for to get a breakthrough like that.So it's arguable that some patients are gonna need more than two or three medicinal doses of these medicines. [00:48:00] And only time will tell, you know, as we do more research and work out more of the protocols for treatment, I think it will become obvious what different patients are going to need in terms of those in terms of support, in terms of how many dosesand so on one of the ways Sam Harris describes it is he strived for years to have that experience through meditation and taking it was MDMA helped him experience what the whole experience could be with meditation, which he now says he experiences through meditation. So it's almost like you get to the end point also.That's what it feels like to be fully the one. And then now he meditates to that to knowing that reality, he actually did his first psilocybin experience. I think at the end of last year, you should go and have a look at it and you might want to share it with, I did watch that. I thought it was fascinating.He did MDMA years ago in psilocybin last year and his friend instructed him. I won't actually talk about the instructions. Y'all watch the we'll [00:49:00] listen to the audio cause he has a great disclaimer and I think that's important. The other thing I think that's with touching on is if we keep holding onto 1970s attitudes around this and bring 1970s attitudes to it, I want caution and I want clinical studies and I know you support, let's do it in a very methodological way.That's exactly how to do it. But any moral panic around this to me is looking really fuddy-duddy should this absolutely especially, well, for two reasons, one of them is that firstly, these medicines and particularly the mushrooms and some of the other psychedelic plant medicines are readily available.And so, you know, the people suggest that, you know we should somehow withhold these from people is actually very short-sighted because what will happen is, and what is happening now is that the longer that these medicines take to be above ground and in medically controlled environments, the more people will go to [00:50:00] the underground and take risks to get better because people will do anything.So, you know, like we only get one life, one short line, these medicines really reiterate that well in this incarnation anyway, you know, so the fact of the matter is if people are really sick and they've been suffering for years and decades, they are going to do. And as, as there's more many media articles about these treatments, they'll just go and find the treatments.Now, there are many underground practitioners who are outstanding and hopefully they'll find them, but there's as inevitably happens in any sector that is taking off they'll also be Cowboys that come in and who will put up their shingles and who will put themselves out there as psychedelic assisted therapists who don't have the experience either with dosing or holding the space or integrating patients properly.And then there could be adverse events that do occur. [00:51:00] So we need to accelerate access to these treatments as fast as we can. It's just imperative that you know, we do that now. And of course, you know, there's plenty of space to continue research in this space. At the same time, the two are not mutually exclusive.We can provide access and start training all these veterans and first responders and others, our brothers, our sisters, our mothers, our fathers, our employees who will also many of whom are suffering. Especially in these, you know, coming out of post COVID world where we're seeing the terrible harms that have been done, especially to children and young people and older people as well.Who've been. And we need to provide solutions. The elephant in the room is the lack of treatment innovation for over five decades. That is what we need to be talking about. Not about more tele health, not about training more psychiatrists and psychologists or more antidepressants. It can't be just more and more antidepressants when the success rate is so low and [00:52:00] placebos often perform nearly as well.If not as well, when there is an urgency. Well, I would I mental health crisis beginning. So, you know, so yeah, so we need to get away from these attitudes of 50 years ago, you know, it's, it's 2021 right? Well, there hasn't really been a breakthrough in mental health since 1980s and nineties when antidepressants hit the market really full force.So if you haven't had a transformation in that entire sector, yet mental health is getting worse and worse and worse. Surely if we have a potential pathway and again, it's not a panacea, we're not saying it is for everyone. It's not suited to everyone. It needs to be done under controlled conditions with a very well-trained expert guide with all those caveats, it becomes a point.I think it was just a political football, right. And, you know, and, and it's great to say the Australian government actually you know, supporting files. And in fact, you know, the 15 million that the Australian government has announced [00:53:00] is actually larger than any other government in the world has actually announced.That's fantastic. We're out of the fuddy duddy category. If you look at it now, Sharon in Australia actually. The potential to lead in this space, the latest in this space, we've got fantastic scientists. We have amazing researchers, amazing medical doctors who really care about their patients and want to get them well.And I should also say that there's a massive market opportunity for Australia. You know, the market is in valued. Like it's, it's like some estimates are as high as $200 billion marketplace for psychedelic medicines over the next few years. And we're seeing startups sitting up every, you know, almost every two weeks since Peter and I started Mind Medicineso there's one of the challenges though that you can't patent the MDMA stretch all the psilocybin structure so startups are coming in so [00:54:00] big pharma isn't necessarily. Yeah, it's going to be funding it, which is why there's so many individuals who are funding it right now to make a difference in the world.They're literally doing it as a charitable donation. Yeah. Yeah. Well, we certainly do that, but there's also startups. Commercial startups will pro profit startups around the world. Probably more than 50 now, who are listed on various stock exchanges who are investing in reinventing the molecules, manufacturing, new medicines, rollout of clinics and so on.So there will be for-profit models where people will make a lot of money, but we say it's really important to do then ethical way. And, and we hope that the for-profit and not-for-profit sectors can work effectively together to make sure that these medicines don't get priced out of, you know, out of the market.I mean, so that, you know, anyone can get access to them, not just wealthy people, cause that would be a travesty. Thank you so much tenure. I really appreciate it. I find this conversation truly fascinating. I do follow what you do. I have attended the [00:55:00] videos that you've been sharing, the the study out of Israel.I watched that and I was really interested in it. Congratulations. The other thing that I was thinking is I might be able to send you some of my, I've got some beautiful songs and recordings on my record albums. Some of which have been informed by. You know, my experiences with the medicines and some of the insights that I've received.And so I'd love to share them with you anyway. That'd be great. Thank you. That's really kind of, you send through the links because I think that to be informed is to stop moral panic, to be informed is to understand how we can support people who are suffering unnecessarily. So anything that we can do to access the information that's going to decode our brains from 1970s, thinking to where the current research is, which has a lot of credibility.A lot of legitimacy in the world is the political groundswell is going to shift the attitude towards it is going to shift until I believe in our lifetime. It is shifting. I mean, this is inevitable, like within the native cities, [00:56:00] yes. Medicines will become much more readily available. Not only I think, will they be available in the middle?Yeah. Environments, but over time, they'll become available to those who are seeking personal development, creative development, Tania lovely connecting with you. I really appreciate your time. Where can people find out more about what you do and the movement, if they just want to start paying attention to this as what's coming in the future?Absolutely. So, you know, we'd love you to look at our website, mind medicine, australia.org. We are a registered charity, so please if you can donate small and large donations all make a huge difference in the mission to make these medicines available. And to heal the suffering that's occurring. Yeah.So please support us. Look at our learn section on our website. Join our chapters. We have 30 chapters around Australia, New Zealand attend our events. We have lots of free webinars. We have a global summit in November. Register if [00:57:00] you're a therapist registered for the certificate in psychedelic therapies just get involved.Reach out. We also have volunteering opportunities and we also do advertise, you know, we're expanding a team. So we have some wonderful jobs coming up. Fantastic. Congratulations on how far it's come. They were looking for a general manager at the moment, so, wow. Okay. Good plug. I love it. Fantastic. All right.Well, I recommended I follow you and your work and I've, as I said, attended a couple of your classes. I think it's fascinating work and it's unbelievably important and significant. So thank you so much for your time Tania I really appreciate. Thank you, Sharon. Fascinating talking with you and I'm thankful.That'd be great. Thanks so much. Thank you.
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Sertraline, also known by the brand game Zoloft, is a selective serotonin reuptake inhibitor (SSRI) that is commonly associated with being an antidepressant. There are many indications for sertraline being for depression, OCD, panic disorder, PTSD, PMDD, and anxiety. Although the manufacturer established a max daily dose of 200 mg/day higher doses from 250-400 mg/day have proven beneficial in clinical practice. Sertraline is not to be used during or within 14 days of a MAOI. Common side effects are nausea, dizziness, dry mouth, sweating, diarrhea, upset stomach, and trouble sleeping. There is a black box warning for Suicidality and antidepressant drugs but that increased risk has been seen in patients under the age of 24. Regardless it is important to monitor a patient for clinical worsening of symptoms and for the emergence of suicidal thoughts and behaviors. Go to DrugCardsDaily.com for my episode show notes which will contain a drug summary, quiz, and a link to FREE drug card sheets. SUBSCRIBE on Spotify or Apple Podcasts or search for us on your favorite place to listen to podcasts. I will go over the Top 100-200 Drugs as well as throwing in some recently released drugs that peak my interest. Also, if you'd like to say hello, suggest a drug, or leave any constructive feedback on the show I'd really appreciate it! Leave a voice message at anchor.fm/drugcardsdaily or message us through twitter @drugcardsdaily --- Send in a voice message: https://anchor.fm/drugcardsdaily/message
Antidepressants: SSRI, SNRI, ATYPICAL, MAOI, TCA Antipsychotic (First Generation)
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The Simple Nursing Podcast - The Simplest Way To Pass Nursing School
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We discuss Easter Island, home of the famous Moai Statues and the mystery of the society that built them.
In this episode, Jessica shares her journey to the Eagle Condor Alliance in Colombia where she experienced traditional Ayahuasca, San Pedro, and Temazcal Ceremonies. Jessica explains the different ceremonies she participated in, how the Sacred medicine moved through her body, and what it was like re-integrating into the world after rediscovering the self.*******Jessica was misspoken - the leaf contains the DMT and the vine contains the MAOI inhibitor*******Jessica & Breann:Email: goodmedicinepodcast@gmail.comInstagram: thegoodmedicinepodcastPatreon: https://www.patreon.com/goodmedicinepodcastMusic by Justin Colson
Salvia comparable to DMT? What is the difference between salvia and #DMT? DMT is mother of Psychedelics , where as salvia is very milder version of it . But once you do DMT it open your Psychedelic window . With this you can creep out of the window with other Psychedelics like LSD, Shrooms,ACO DMT .quora - salvia-and-DMT N,N-Dimethyltryptamine (DMT or N,N-DMT) is a chemical substance that occurs in many plants and animals and which is both a derivative and a structural analog of tryptamine.[3] It can be consumed as a psychedelic drug and has historically been prepared by various cultures for ritual purposes as an entheogen.[4] DMT is illegal in most countries. DMT has a rapid onset, intense effects and a relatively short duration of action. For those reasons, DMT was known as the "business trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or magic mushrooms.[5] DMT can be inhaled, ingested, or injected and its effects depend on the dose. When inhaled or injected, the effects last a short period of time: about 5 to 15 minutes. Effects can last three hours or more when orally ingested along with an MAOI, such as the ayahuasca brew of many native Amazonian tribes.[6] DMT can produce vivid "projections" of mystical experiences involving euphoria and dynamic hallucinations of geometric forms.[7] Effects Salvinorin A § Pharmaceutical action Aside from individual reported experiences there has been a limited amount of published work summarising salvia divinorum effects. A survey of salvia users found that 38% described the effects as unique in comparison to other methods of altering consciousness. 23% said the effects were like yoga, meditation or trance.[71] Users have written prose about their experiences;[72][73] some describing their visions pictorially, and there exist examples of visionary art which are 'salvia-inspired'. Others claim musical inspiration from the plant.[73] Salvia divinorum is native to the Sierra Mazateca in Oaxaca, Mexico, where it is still used by the Mazatec, primarily to facilitate shamanic visions in the context of curing or divination. S. divinorum is one of several species with hallucinogenic properties that are ritually used by Mazatec shamans. In their rituals, the shamans use only fresh S. divinorum leaves. They see the plant as an incarnation of the Virgin Mary, and begin the ritual with an invocation to Mary, Saint Peter, the Holy Trinity, and other saints.[1] Ritual use traditionally involves being in a quiet place after ingestion of the leaf—the Maztec shamans say that "La Maria (S. divinorum) speaks with a quiet voice."[7] It is also used remedially at lower dosages as a diuretic, and to treat ailments including diarrhea, anemia, headaches, rheumatism, and a semi-magical disease known as panzón de borrego, or a swollen belly (literally, "lamb belly").[9][21] weki The history of the plant is not well known, and there has been no definitive answer to the question of its origin. Speculation includes Salvia divinorum being a wild plant native to the area; a cultigen of the Mazatecs; or a cultigen introduced by another indigenous group. Botanists have also not been able to determine whether it is a hybrid or a cultigen.[22] weki --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/vegansteven/message
A guide for Doctors regarding levels of tyramine in food.For more information please refer to the guide on Psychotropical Website: https://psychotropical.com/wp-content/uploads/2020/02/9-MAOI-diet-short-2020_for-pdf_v.pdf
In this podcast episode, we discuss a case of a 65-year-old patient with first-episode MDD that is treatment resistant. With the expertise of Dr. Ken Gillman, we unpack how to manage this case with an MAOI. Download a PDF of this interview here Become a premium member of the Psychopharmacology Institute
This episode is the starter pack for the use of monoamine oxidase inhibitors in psychiatry practice. We learn the mechanism of action, food-related instructions and MAOI drug interactions. Download a PDF of this interview here Become a premium member of the Psychopharmacology Institute
Host: Matt Birnholz, MD Guest: Catherine Poulos, PMHNP- BC Please click for Full Prescribing Information. INDICATION AND LIMITATIONS OF USE MYDAYIS® (mixed salts of a single-entity amphetamine product) is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in patients ≥13 years. Patients ≤12 years experienced higher plasma exposure at the same dose and higher rates of adverse reactions, mainly insomnia and decreased appetite. IMPORTANT SAFETY INFORMATION WARNING: ABUSE AND DEPENDENCE CNS stimulants, including Mydayis, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy. Contraindications Known hypersensitivity to amphetamines or other ingredients of Mydayis. Angioedema and anaphylactic reactions have been reported with other amphetamines. Use with monoamine oxidase inhibitors (MAOIs) or within 14 days of last MAOI dose, due to increased risk of hypertensive crisis. Warnings and Precautions Avoid use in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart arrhythmia, coronary artery disease, and other serious heart problems. Sudden death, stroke and myocardial infarction have been ...
Host: Matt Birnholz, MD Guest: Joel L. Young, MD Please click for Full Prescribing Information. INDICATION AND LIMITATIONS OF USE MYDAYIS® (mixed salts of a single-entity amphetamine product) is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in patients ≥13 years. Patients ≤12 years experienced higher plasma exposure at the same dose and higher rates of adverse reactions, mainly insomnia and decreased appetite. IMPORTANT SAFETY INFORMATION WARNING: ABUSE AND DEPENDENCE CNS stimulants, including Mydayis, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy. Contraindications Known hypersensitivity to amphetamines or other ingredients of Mydayis. Angioedema and anaphylactic reactions have been reported with other amphetamines. Use with monoamine oxidase inhibitors (MAOIs) or within 14 days of last MAOI dose, due to increased risk of hypertensive crisis. Warnings and Precautions Avoid use in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart arrhythmia, coronary artery disease, and other serious heart problems. Sudden death, stroke and myocardial infarction have been ...
This is a diet guide about tyramine whilst taking MAOI. Go to psychotropical.com for more information
Healthcare professionals and patients may not realize that methylene blue has monoamine oxidase inhibitor (MAOI) properties. Methylene blue should generally not be given to patients taking serotonergic drugs. When should patients stop taking SSRIs prior to methylene blue use? When should they be restarted? In this session, we will review the MOA of this common dye utilized in surgery and review ways to prevent a possible lethal reaction.
This is an introductory explanation for patients who are considering taking MAOIsGo to psychotropical.com for more info.
If psychedelics are one thing we can all agree on, is that it will make a lot of people happy. There's a lot of people who could use a heavy dose of psychedelics to stop being angry. There's something about stepping outside of yourself and even up the reality that comes with these types of experiences that is getting even more useful in a culture that is becoming even more obsessed with the day to day and itself. In this episode of Made You Think, Nat and Mansal Denton talk about Food of the Gods by Terence McKenna. This is a fun book episode about Terence McKenna’s take on psychedelics. First of which is that because mushrooms or “shrooms” basically grow faster in Caledon it leads us to see respect and certain religious adoration towards animals and lastly, that psychedelics are originators of religion. We cover a wide range of topics, including: What are psychedelics and its misconceptions How the society take these substances into account Why animals seem keen into psychedelics How psychedelic substances are lowering the floodgates of one’s experience Terence McKenna’s TWO ideas on psychedelics How religion coincided with psychedelics Mansal’s authentic Ayahuasca experience and the hunt for a good Shaman And much more. Please enjoy, and be sure to grab a copy of Food of the Gods by Terence McKenna! If you enjoyed this episode, be sure to check out our episode on Smoke Signals by Martin A. Lee, a book about the history of marijuana and the war on drugs in the US. Check also The Power of Myth by Joseph Campbell that talks about the origin of religions. Be sure to join our mailing list to find out about what books are coming up, giveaways we’re running, special events, and more. Links from the Episode Mentioned in the show Nootropedia [1:28] Nootropics [1:35] Psychedelics [1:39] OYASIN [1:46] Psilocybin mushroom/Magic Mushrooms “Shrooms” [4:28] MDMA for PTSD [4:30] DMT [11:43] Ayahuasca [11:59] Chacruna Leaves [13:37] N,N-DMT [13:49] 5-MeO-DMT [14:00] LSD [15:39] Stoned Ape Theory [16:20] Dominator culture [31:38] Marijuana [32:17] Vape [34:30] MAOI [36:01] Nicotine gum [36:43] Juul Vapes [37:00] Hamilton’s Pharmacopeia [38:21] Soylent [39:07] Polio [41:12] Opium [41:21] Ibogaine [44:29] Iboga [44:51] Burning Bush [49:40] Amanita Muscaria Mushroom [50:21] Aztec [54:31] Sweat Lodge Ceremony [55:06] Kundalini yoga [57:43] Ayahuasca Shaman [1:00:00] Books mentioned Food of the Gods by Terence McKenna How To Change Your Mind by Michael Pollan [4:15] The Doors of Perception by Aldous Huxley [18:23] People mentioned Mansal Denton [0:33] Michael Pollan [4:15] Trump [8:15] Nixon [9:58] Timothy Leary [10:07] Dennis McKenna [17:07] Albert Hoffman [17:46] Ram Dass [17:56] Aldous Huxley [18:21] Hamilton Morris [38:21] Dr. Dan Engle [47:30] Jesus on Psychedelics [49:45] Santa Claus on Psychedelics [50:07] Show Topics 1:25 - Mansal Denton is the co-host for today’s episode! He has recently left an organization called Nootropedia, where his whole focus was helping people optimize their mental performance using nootropics. He found that some of the best nootropics were psychedelics and from that path he moved into another organization called Oyasin, which is a lifestyle brand reharmonizing people with the natural world. A high-level view of what he's interested right now: he believes that all of the external problems in the world are a manifestation of what's going on in our minds collectively at the society and that psychedelics can be a powerful tool to solve what's going on in our minds. He thinks that transformational or peak experiences are things that we all crave and could help change our perspectives someway. 4:00 - Interesting shift of perspective in society about Psychedelics and plant medicines. “How To Change your Mind” by Michael Pollan is a great influence to this. Some of the kinds of psychedelics are Silicide, Magic Mushrooms, and MDMA for PTSD. It is so compelling and helpful for PTSD. 6:25 - If psychedelics are one thing we can all agree on then it will make a lot of people happy. There's a lot of people who could use a heavy dose of psychedelics to stop being angry. There's something about stepping outside of yourself and even up the reality that comes with this types of experiences that is getting even more useful in a culture that is becoming even more obsessed with the day to day and itself. Imaginary world which is everything in the internet, a reality that doesn’t exist in a physical way. Recreating our relationship with our internal map is something everyone can benefit from, like meditation, like a recognition of something lost. 7:55 - Society's take on psychedelics. Safety and inherent risks with these substances despite its legality in some places. Be smart. In today’s generations, there are negative responses to these plant medicines. War on drugs has done injustice to psychedelics. 10:54 - What kinds of drugs people are comfortable taking and which ones they aren't. Coffee, alcohol, tobacco, and aspirin are drugs all of us use that alter our daily experience. 12:00 - Drugs and hunting. Drugs and animals. Ayahuasca doses given to dogs for more effective hunting today in the jungle. Which plants are mixed with Ayahuasca. There’s an archaeological evidence that people were making ayahuasca thousands of years ago. 14:42 - McKenna’s Hypothesis: hallucinogenic compounds may have actually had influence in developing our own self-reflective abilities. DMT vs LSD trips. Stoned Ape Theory. 18:16 - Brain as primarily a filtering tool. Idea that the brain functions not to understand our environment but to filter out all of the less important noise from The Doors of Perception. Consciousness as a subtractive process, not an additive. Psychedelic substances are lowering the floodgates of one’s experience to open your senses to everything that’s going on in your environment that you’re normally unaware of. Examples: appreciating trees, books you never heard of and hearing it a lot of times after within a week. There is some part of your brain that becomes receptive to that specific thing. 20:57 - Research on the brain about finding truth and logic in certain aspects of life are actually developed more with the intention on how can you create truth to make others believe. Humans are actually social animals. Our brain may not be interpreting actual reality rather it is interpreting reality socially. Elements of stimuli not normally present in our normal consciousness. 22:20 - Why animals seem interested in psychedelics. There’s some element in psychedelics that’s completely pressing reset in our consciousness that almost every species can benefit from. It’s actually an evolutionary disadvantage for animals to be tripping but all animals have habitual patterns which are sometimes helpful and sometimes not. Having these patterns interrupts allowed animals to change habits that proved to be more advantageous. Animals know how to micro-dose psychedelics. The higher the dose of LSD the more tolerant you become. 25:53 - Intention VS. External Environment. Psychedelics can be powerful tools or just for recreational use. Retreats for self-reflection. McKenna says there’s a stigma against taking drugs or substances alone. Respectful use in productive settings and not in rave parties. Taking it on your own makes more valuable experiences. When with somebody, sometimes the ideas come from all over the place and it’s hard to have coherent conversations when you are tripping. It is important to identify what’s the intention to take psychedelics, ex. to escape reality or to explore and reflect or connect. It’s harder to be locked into a monotonous routine that you hate if you’re having these psychedelics driven wake ups every few months. 31:38 - Legal drugs fits in the Dominator Culture. How would work, life, and environment be changed if people had access to psychedelics. We’re seeing it a little bit with Marijuana, as it becomes more and more legalized. It will always depend on the intentions. Stimulants and alcohol fall in the legal drugs category. A lot of these drug compounds create a baseline that is manageable. Psychedelics create peak experiences. There’s so much value in doing both in a regular basis. 34:30 - Why is Nicotine addictive? Nicotine itself is not actually a dangerous chemical, cigarettes are. If you’re smoking pure tobacco, that’s probably safe. Vapes are intense smoking administration method. Nicotine is only addictive when it is combined with MAOI. Hamilton’s Pharmacopeia on MAOI Inhibitors. 39:39 - How people seem to believe that Science and Rationality are the new god. Science is great but incomplete and can get things wrong like drugs with side effects. Drugs that you can do while going to work or do more work are okay while drugs that you would have to relax in the process aren’t okay, for instance, Marijuana. The term “Marijuana”. The propaganda on Mexicans and Blacks liking to get high to not do work and then attack people as racism. 43:07 - Empathy is so heightened in psychedelics - you start to feel this sense of protection for the earth. Michael Pollan’s take on psychedelics relating to modern environmental movement came predominantly out of psychedelic experiences in the 60’s and 70’s. 44:27- Ibogaine experience. Effects of Ibogaine. There are so many great applications of Iboga but high doses can harm the ones with heart conditions. It can cure addiction, like alcoholism, as well. Ayahuasca has similar effects, generally less statistically significant than Iboga. You can find Ayahuasca, LSD or mushrooms even in the US. Iboga it’s not something you mess around with on your own. Where do people do or take Iboga? 48:07 - Mckenna’s Idea that because mushrooms grow faster in Caledon we see respect and certain religious adoration towards cows in some eastern religions. A lot of religious and cultural texts have similarities, plausible stories of psychedelics being involved. Was Jesus the effect of collective consumption of psychedelics? Psychedelics are so mind-altering, great substances to help humans write down the myths. 51:13 - McKenna’s Idea that psychedelics are originators of religion. In doing them, you experience many of the same feelings and sense of connection and visual experiences of some of what you might see in religious texts. Experience on DMT. McKenna says, “God is not an idea. God is a lost continent in the human mind”. Divinity schools will agree that psychedelics can reliably create mystical experiences and connect to a Higher Power. Ayahuasca sessions and spiritual connection. Aztec religion takes Silicide mushrooms as flesh of the Gods. 55:06 - What kind of Higher Power you’re relating with -- Nature, External, or Ephemeral? Spirituality is very personal. You cannot really explain it but just feel it. The importance of doing deep multi-experience retreats is that you get to connect to a higher power. Mansal’s Kundalini yoga experience. Sweat lodge ceremony. 1:00:15 - How to find a good Shaman and the authentic Ayahuasca experience. Mansal’s recommendation is find referrals, but you don’t need necessarily to travel Peru. For newbies, it’s best to take Ayahuasca with a Shaman to keep you safe. In his hunting experiences, Mansal finds it valuable to do psychedelics before & after hunting yet never during the hunting. 1:05:50 - How to get connected with Mansal IG: @mansaldenton and grab Mansal’s email listening to the episode. Reach Nat on Twitter @Nat Eliason (@nateliason) and let him know what you are yours thoughts about the book and the episode. Leave us a review on iTunes and let your friends know about it. If you enjoyed this episode, don’t forget to subscribe at https://madeyouthinkpodcast.com
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Pseudoephedrine is commonly used to help relieve nasal congestion. There are some adverse effects you need to be aware of with pseudoephedrine. Insomnia, increase in blood pressure, and urinary retention are all possible. When I assess a patient using pseudoephedrine, I like to investigate blood pressure, history of urinary problems and insomnia history. Pseudoephedrine can cause the prescribing cascade. I lay out examples in the podcast. Pseudoephedrine should not be utilized with MAOI's if possible - I discuss the reason for this in the podcast. Enjoy the show and don't for get your FREE 31 page resource!
This episode covers medications including antidepressants and rapid review. The goal of this podcast is to help medical students study for high yield topics and actively test knowledge. Timestamp: 00:00 Intro 01:15 Antidepressants 19:10 Rapid Review Written, produced and recorded by Josh Bradford. Comments, constructive criticism, or questions please contact at medicalstudentstudycast@gmail.com Support by donating to anchor.fm/medical-student-studycast or patreon.com/medicalstudentstudycast Tags: SSRI, SNRI, bupropion, fluoxetine, serotonin, serotonin syndrome, depression, anxiety, PTSD, OCD, MAOI, tyramine crisis, tricyclic antidepressant, ECT, psychiatry clerkship, rotations, psychiatric, behavioral health, USMLE, COMLEX, step 2, level 2, clinical, shelf exam, medicine --- Support this podcast: https://anchor.fm/medical-student-studycast/support
[Guest: John Chavez] DMT ("The Spirit Molecule") has gained growing interest as a powerful tool for spiritual awakenings. But what if, the human body is designed to make its own DMT from the inside out? What are the pros and cons of ingesting DMT from outside in, instead of producing it from the inside out? Join Dr. Edith and DMT researcher John Chavez, for a fascinating journey into the science and physiology of the DMT-experience. What does DMT have to do with spiritual enlightenment, health and healing, telepathy, and other seemingly "superhuman" possibilities? WARNING: This episode contains some ADULT LANGUAGE. If you have little ones around, please grab your headsets now. Questions and topics explored: * The surprising backstory of John's unexpected awakening experience, which changed the course of his life forever. * Could it be that the human body is designed to make its own DMT from the inside out? * The important role of DMT in normal human physiology - tissue healing, antioxidant, dream states, etc. * What are the pros and cons of taking a psychedelic substance from the outside in vs. producing this powerful medicine from the inside out? * The Ayahuasca brew contains DMT and MAOI. What about the production of MAO and MAOI in the human body? * John coined the term "Endo-huasca." What is Endo-huasca? * When it comes to studying these para-normal/superhuman or mystical states, what are major challenges and limitations of conventional scientific research? * What does the Gamma brainwave state have to do with the mystical awakening experience and DMT? * What do these mystical states have to do with the Electric Body (Dr. Robert Becker's work)? * Is it possible that we could grow new limbs like salamanders? * How can DMT research help us solve the greatest problems in our society - e.g. stress, anxiety, cancer, chronic illnesses and disease? * Learn John's #1 advice for tapping into our next level of human possibilities! Leave a comment below - let us know what you think! --------- Explore John Chavez's research on DMT - www.Q4LT.com/ Connect with Dr. E - www.SuperWellness.com / www.DrEdithUbuntu.com Pick up your copy of SuperWellness on Amazon.com!
Simply put, Changa is a powerful psychedelic smoking blend. It is a combination of herbs infused with dimethyltryptamine (DMT) and containing some form of monoamine oxidase inhibitors (MAOi). However, describing the "simply put" physical parameters of a psychedelic compound is as gross an understatement as saying sex is, simply put, a penis penetrating a vagina.... there is SO MUCH MORE to it than "simply put", which is why we have Giorgia Gaia on the show. Giorgia Gaia---author of "Changa's Alchemy - Narratives of Transformation in Psychedelic Experiences"---is an independent researcher with a masters degree in Cultural and Social Anthropology and another MA degree in Theology, specifically Western Esotericism, at the University Van Amsterdam. Since her early twenties, she has been working as an electronic musician and event organizer, also in international festivals. *** If you are enjoying the show, I ask you to please contribute to the show by way of a one-time donation or by becoming a continuous supporter on Patreon. PLEASE SUPPORT (ME AND) THE SHOW ON PATREON: https://www.patreon.com/jameswjesso OR VIA A ONE-TIME PAYPAL DONATION: http://paypal.me/JWJesso *** Episode Breakdown The scope of Giorgia's research What is Changa? (pharmacology, history, cultural impact) Changa within the underground electronic music culture. What denotes "transformation" within the context psychedelic use. The importance of narrativizing profound psychedelic experiences. Prevailing themes or commonalities in the metaphysics and cosmology of changa users. The implication and complications of studying changa culture as an anthropologist whilst directly participating in that culture. Safety, caution, harm reduction advice. *** See Bit.ly/ATTMind53 for full show notes and other bonus content! AND featured image courtesy and copyright of Mugwort Designs
Our quick hit guide to three big types of anti-depressants: SSRI's, SNRI's, and MAOI's. This is a very beginner segment on some of the anti-depressants you make come across when getting help for your disorder.
Musician Tony Moss, who has 18 years experience drinking ayahuasca, explains what this medicinal brew from the Amazon rainforest is in his eyes. Moss says the most common ailments he's seen healed during an ayahuasca experience are depression and any kind of trauma related mental or physical illness. Moss says the ayahuasca somehow safely brings the user back to the original trauma, allows them to move into a safe space and process it. To learn more about how ayahuasca and other natural therapies are healing trauma worldwide, please visit http://www.reset.me . Ayahuasca is a South American psychedelic tea containing the potent psychedelic chemical N,N-dimethlytryptaime (DMT), which is a human neurotransmitter. The ayahuasca vine (Banisteriopsis caapi) is combined with the leaves from the shrub Psychotria viridis (or other DMT containing plants) to create the tea. Ayahuasca is the name given to the Banisteriopsis caapi vine and also the foul-tasting tea. It is quite remarkable that the Indians discovered this powerful combination hundreds of years ago considering there are more than 40,000 plant species in the Amazon. The ayahuasca vine contains chemicals known as monoamine oxidase inhibitors (MAOIs) that allow the body to absorb the DMT from the leaves. Without the MAOI, the DMT would be destroyed by monoamine oxidase in the gut and no effects from the DMT would be felt. The word 'ayahuasca' translates to 'vine of death' or 'vine of souls'. This powerful tea induces intense hallucinations and introspection. The entire ayahuasca experience lasts for approximately 8 hours, with the strongest effects lasting 1-3 hours. Vomiting and occasionally diarrhea, which the natives call 'la purga' (the purge), are considered part of the experience. This purging process is medically beneficial, as it clears the body of worms and other parasites . Ayahuasca has shown great success as a treatment for addiction, depression, and cancer. A study combining ayahuasca use and psychotherapy for addiction treatment yielded positive results in two thirds of the patients . Research indicates that ayahuasca has antidepressant qualities. Blood tests of long-term ayahuasca users have shown an increased density of serotonin receptors compared to those who do not use ayahuasca. It should be mentioned that the SSRI class of antidepressants (Prozac, Zoloft, Paxil, etc.) actually reduce the density of serotonin receptors in users over time, which can lead to chronic depression . Ayahuasca is non-addictive and is not neurotoxic, or poisonous to nerve tissue such as the brain or spinal cord, in any way.
The Experts Speak - An Educational Service of the Florida Psychiatric Society
Stephan Quentzel, MD, explains the logic and advantage about the new delivery formulation of an MAOI antidepressant. This old class of medications can now be used in a safer manner. He also talks about the history of MAOI, how it works, etc.