Podcasts about Citalopram

In this episode of the Top 200 Drugs Podcast, I cover glyburide, citalopram, olmesratan, carvedilol, and tiotropium. Glyburide is a sulfonylurea that is well known to cause hypoglycemia and weight gain because it stimulates the pancreas to increase insulin release. Citalopram is an SSRI most well known for its potential to increase the risk for QTc prolongation. It has a notorious drug interaction with omeprazole Olmesartan is an ARB that can be used for hypertension. Hyperkalemia is an electrolyte imbalance that can be caused by its use. Carvedilol is one of the few beta-blockers with significant alpha-blocking and beta-blocking activity. I discuss what this means in this Top 200 drugs podcast. Tiotropium is an anticholinergic medication that can open the airway. It is most commonly used for COPD.

INTERVIEW: Bex Pemberton & Tim Miller from Tealskie on new single 'Citalopram' by Zac Hoffman on Radio One 91FM Dunedin

In episode 247 of The Just Checking In Podcast we checked in with a man called Sean. Sean works for the PSSD Network, which is an organisation based in Australia, made up of people who suffer from a condition called Post-SSRI Sexual Dysfunction (PSSD). PSSD describes a debilitating condition which a subset of people live with and follows the use of SSRI and SNRI medication. A condition like this is an example of something called iatrogenic harm i.e. medical harm induced unintentionally by a physician or surgeon or by medical treatment or diagnostic procedures. Common symptoms of PSSD include, but are not limited to: genital numbness, a complete loss of libido, erectile dysfunction, vaginal dryness, anhedonia and emotional blunting. This condition is very controversial in medical circles and the mainstream mental health conversation because it goes against the established narrative that selective serotonin reuptake inhibitors (SSRIs) are all universally safe. The PSSD Network's goal is to increase awareness of PSSD, expedite research and offer support to patients and their loved ones as necessary. The PSSD Network's mission is to speed up research and find treatments or a cure for PSSD. Sean himself lives with PSSD after he was prescribed two SSRIs for long-term issues he had with anxiety. The first he was prescribed was Prozac by his GP which had no side-effects on him but didn't work for him and he came off it very quickly. However, he continued to suffer from anxiety and during his university degree, he went back to his GP and was prescribed an SSRI called Citalopram. It was whilst he was on Citalopram that he had these severe side-effects which included sexual dysfunction, genital numbness, emotional blunting and lost libido. He came off the citalopram but the side-effects didn't go away and he came to the eventual conclusion that he had PSSD. After not being believed by multiple doctors, he eventually found medical professionals who believed him and has been working out how to manage it and treat it for the last two years. In this episode we discuss how the SSRI caused him to develop PSSD, his self-awareness about the condition and the community he has found in the PSSD network to help him with it. We discuss the role of the pharmaceutical industry in pushing SSRIs onto medical professionals who then prescribe them to patients and what needs to change in order for patients to be given full, informed consent before taking any of these drugs. We also debate why critics of the PSSD network accuse them of being ‘anti-medication', why they argue that they don't fall into that camp, Sean's recovery journey and the various methods he's tried to manage the PSSD or heal from it. We finish by discussing the work he does with the PSSD network, the research that still needs to be done around SSRIs and what is the right route forward to ensure people who need medication and would be helped by taking them are given them and who doesn't need them and could be harmed. As always, #itsokaytovent You can find out more about the PSSD Network here: https://www.pssdnetwork.org/ You can follow them on social media below: Instagram: https://www.instagram.com/pssd_network/?hl=en-gb Twitter: https://x.com/pssdnetwork?lang=en Support Us: Patreon: www.patreon.com/venthelpuk GoFundMe: www.gofundme.com/f/help-vent-supp…ir-mental-health Merchandise: www.redbubble.com/people/VentUK/shop Music: @patawawa - Strange: www.youtube.com/watch?v=d70wfeJSEvk

My name is Kim Newlove, and I'm an Ohio-licensed pharmacist. Welcome to the 30th episode in my drug name pronunciation series. Today, we're talking about citalopram (Celexa) and escitalopram (Lexapro).   In this episode, I divide all four drug names into syllables, tell you which syllables to emphasize, and share my sources. The written pronunciations can be helpful, so you can see them below and in the show notes on thepharmacistsvoice.com.  Thank you for listening to episode 274 of The Pharmacist's Voice ® Podcast! To read the FULL show notes, visit https://www.thepharmacistsvoice.com.  Click the Podcast tab, and select episode 274. Subscribe to or follow The Pharmacist's Voice ® Podcast to get each new episode delivered to your podcast player and YouTube every time a new one comes out!   Apple Podcasts   https://apple.co/42yqXOG  Spotify  https://spoti.fi/3qAk3uY  Amazon/Audible  https://adbl.co/43tM45P YouTube https://bit.ly/43Rnrjt   Citalopram = si-TAL-uh-pram  Emphasize TAL Source:  clinical practice and popular opinion   Celexa = se-lek-sa No emphasis is indicated by my source, but I emphasize LEX. Source:  medication guide, FDA's website   Escitalopram = ES-si-TAL-uh-pram Emphasize ES and TAL.  TAL gets the most emphasis. Source:  clinical practice and popular opinion   Lexapro = leks-a-pro No emphasis is indicated by my source, but I emphasize LEX. Source:  medication guide, FDA's website   Thank for joining me to learn how to say citalopram, Celexa, escitalopram, and Lexapro. If you know someone who needs to learn how to say citalopram, Celexa, escitalopram, and Lexapro, please share this episode with them.     Links from this episode Celexa medication guide - FDA Website Lexapro medication guide - FDA Website USP Dictionary Online (aka “USAN”)  **Subscription-based resource USP Dictionary's (USAN) pronunciation guide (Free resource on the American Medical Association's website) The Pharmacist's Voice ® Podcast Episode 272, pronunciation series episode 29 (losartan) The Pharmacist's Voice Podcast Episode 269, pronunciation series episode 28 (tirzepatide) The Pharmacist's Voice Podcast Episode 267, pronunciation series episode 27 (atorvastatin)  The Pharmacist's Voice Podcast Episode 265, pronunciation series episode 26 (omeprazole) The Pharmacist's Voice Podcast Episode 263, pronunciation series episode 25 (PDE-5 inhibitors) The Pharmacist's Voice Podcast Episode 259, pronunciation series episode 24 (ketorolac) The Pharmacist's Voice ® Podcast episode 254, pronunciation series episode 23 (Paxlovid) The Pharmacist's Voice ® Podcast episode 250, pronunciation series episode 22 (metformin/Glucophage) The Pharmacist's Voice Podcast ® episode 245, pronunciation series episode 21 (naltrexone/Vivitrol) The Pharmacist's Voice ® Podcast episode 240, pronunciation series episode 20 (levalbuterol) The Pharmacist's Voice ® Podcast episode 236, pronunciation series episode 19 (phentermine)  The Pharmacist's Voice ® Podcast episode 228, pronunciation series episode 18 (ezetimibe) The Pharmacist's Voice ® Podcast episode 219, pronunciation series episode 17 (semaglutide) The Pharmacist's Voice ® Podcast episode 215, pronunciation series episode 16 (mifepristone and misoprostol) The Pharmacist's Voice ® Podcast episode 211, pronunciation series episode 15 (Humira®) The Pharmacist's Voice ® Podcast episode 202, pronunciation series episode 14 (SMZ-TMP) The Pharmacist's Voice ® Podcast episode 198, pronunciation series episode 13 (carisoprodol) The Pharmacist's Voice ® Podcast episode 194, pronunciation series episode 12 (tianeptine) The Pharmacist's Voice ® Podcast episode 188, pronunciation series episode 11 (insulin icodec)  The Pharmacist's Voice ® Podcast episode 184, pronunciation series episode 10 (phenytoin and isotretinoin) The Pharmacist's Voice ® Podcast episode 180, pronunciation series episode 9 Apretude® (cabotegravir) The Pharmacist's Voice ® Podcast episode 177, pronunciation series episode 8 (metoprolol)  The Pharmacist's Voice ® Podcast episode 164, pronunciation series episode 7 (levetiracetam) The Pharmacist's Voice ® Podcast episode 159, pronunciation series episode 6 (talimogene laherparepvec or T-VEC)  The Pharmacist's Voice ® Podcast episode 155, pronunciation series episode 5 Trulicity® (dulaglutide)  The Pharmacist's Voice ® Podcast episode 148, pronunciation series episode 4 Besponsa® (inotuzumab ozogamicin) The Pharmacist's Voice ® Podcast episode 142, pronunciation series episode 3 Zolmitriptan and Zokinvy The Pharmacist's Voice ® Podcast episode 138, pronunciation series episode 2 Molnupiravir and Taltz The Pharmacist's Voice ® Podcast episode 134, pronunciation series episode 1 Eszopiclone and Qulipta

Join us for a brief discussion on Celexa (Citalopram).

High Yield Psychiatric Medications Antidepressants Review for your PANCE, PANRE, Eor's and other Physician Assistant exams. Review includes SSRI's, SNRIs, TCAs, MAOIs, Atypical antidepressants, Serotonin modulators. TrueLearn PANCE/PANRE SmartBank:https://truelearn.referralrock.com/l/CRAMTHEPANCE/Discount code for 20% off: CRAMTHEPANCEIncluded in review: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Desvenlafaxine, Duloxetine, Levomilnacipran , Milnacipran, Venlafaxine, Amitriptyline, Clomipramine, Doxepin, Imipramine, Trimipramine, Desipramine, Nortriptyline, Protriptyline, Tranylcypromine, Isocarboxazid, Phenelzine Selegiline, Bupropion, Mirtazapine, Trazodone

Hair loss after chemotherapy is to be expected. But what about when hair loss, thinning hair and scalp issues affect you years after your initial cancer diagnosis?One lady in our community said: "My hair started growing lush and thick 1-2 months after finishing chemo but now a year on from starting hormone therapy it has almost completely gone again. My scalp is visible."We are delighted to invite Eva Proudman to this workshop. Eva is a consultant trichologist, a hair and scalp specialist with over 20 years of experience and a fellow of the Institute of Trichologists.In this episode we will discuss: Why does hair grow back differently after we lose it to chemo sometimes?How does menopause affect hair?Do some cancer drugs like tamoxifen and other medications affect hair?What are proven treatment options?Which supplements work best? Are these safe for someone with a history of cancer?Myth busting: let's talk about rosemary oil, collagen and biotinEpisode Highlights:[05:25] How cold caps work.[09:22] Oestrogen levels affect hair patterns in men and women.[12:21] Launching a new shampoo that helps hair health during menopause.[14:27] Certain medications affect hair health positively or negatively. For example, Citalopram is hair-friendly, while Sertraline may cause shedding.[20:47] The truth about Rosemary oil.[24:00] Is using Biotin worth it? How beneficial is Collagen?[34:23] Balancing nutrients, blood tests reveal deficiencies.[40:30] Q&A with the workshop audience.To contact Eva and for further trichology information and advice visit www.ukhairconsultants.com you can also use this to fill in forms and ask questions. You can also follow Eva's on Instagram here. About Dani:The Menopause and Cancer Podcast is hosted by Dani Binnington, menopause guide, patients advocate for people in menopause after a cancer diagnosis, and founder of the online platform Healthy Whole Me. There is lots of information out there about the menopause but hardly any if you have had a cancer diagnosis as well. Many people say to me they have no idea what their options are, who to ask for help, and that they feel really isolated in their experiences. I started this podcast because there was nothing out there when I was thrown into surgical menopause at the age of 39, which followed on from my cancer diagnosis aged 33.Through the episodes, I want to create more awareness, share information from our fabulous guest experts, doctors and other specialists in the cancer and menopause field. And of course, I will share stories from the people in our community.So that together we can work towards a better menopause experience. For all of us.More educated, better informed and less alone.Connect with Dani:Instagram @healthywholeme Facebook: @healthywholeme Website: menopauseandcancer.org Join Dani's private Facebook group: https://www.facebook.com/groups/menopauseandcancerchathubFor oodles of inspiration, healthy recipes, yoga classes and all round positivity go to her website:...

The 2023 Menopause Society  (NAMS) position statement regarding the non-hormonal treatment of Vasomotor Symptoms- hot flashes and night sweats- was just released. Position statements are expert analyses of current studies in order to determine recommendations based on science, as opposed to what the latest Tik Tok star or celebrity is promoting. Because new studies are constantly being published, there is always new information to inform those recommendations, which is why position statements need to periodically get updated.  Because the position statement is very extensive and long, I have divided it into 3 episodes.  Part 1- Non-hormonal prescription options Part 2 -Over the counter botanicals and dietary supplements  Part 3- Lifestyle; mind-body techniques; acupuncture and cooling devices.  In this episode, I am covering non-hormonal prescription options. My guest is one of the authors of The Menopause Society position statement, Dr. Chrisandra Shufelt. Dr. Shufelt is a certified menopause practitioner of The Menopause Society, the Chair of the Division of General Internal Medicine, Senior Consultant at the Mayo Clinic Women's Health, and Associate Director of Women's Health Research Center at Mayo Clinic in Jacksonville, Florida. The drugs discussed include: Selective Serotonin Reuptake Inhibitors (SSRI) such as Paroxetine, Citalopram, Escitalopram Selective Norepinephrine Reuptake Inhibitors (SNRI) such as Desvenlafaxine, Venlafaxine Gabapentin  Pre-gabalin Clonidine Oxybutynin Suvorexant  Fezolinetant And stick around for the wrap-up at the end. I summarize the recommendations. Other relevant episodes:  Episode 2:Think Your Hot Flashes Can't Kill You? Think Again! Episode 31 The TRUTH About Hormone Therapy: Does it CAUSE or Does it PREVENT Breast Cancer? Episode 77 Fezolinetant! A New Non-Hormonal Hot Flash Drug  For more information:   Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Lauren Streicher, MD is a clinical professor of obstetrics and gynecology at Northwestern University's Feinberg School of Medicine, and the founding medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause. She is a certified menopause practitioner of the North American Menopause Society.  Sign up to receive DR. STREICHER'S FREE NEWSLETTER Dr. Streicher is the medical correspondent for Chicago's top-rated news program, the WGN Morning News, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr. Radio, Nightline, Fox and Friends, The Steve Harvey Show, CBS This Morning, ABC News Now, NBCNightlyNews,20/20, and World News Tonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine, and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.  Subscribe and Follow Dr. Streicher on  DrStreicher.com Instagram @DrStreich Twitter @DrStreicher Facebook  @DrStreicher YouTube  DrStreicherTV Books by Lauren Streicher, MD  Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Sex Rx- Hormones, Health, and Your Best Sex Ever The Essential Guide to Hysterectomy

"...Serotonin syndrome also known as serotonin toxicity is a potentially life-threatening condition due to excessive serotonin levels in the body this can come from using the medication as a therapy due to drug interactions recreational drug use or even intentional overdoses the end result is an increased in the amount of serotonin in the synaptic cleft able to bind serotonin receptors, for example, selective serotonin reuptake Inhibitors like Citalopram inhibit the reuptake of Serotonin into the presynaptic neuron meaning more is available to bind the postsynaptic receptors monoamine oxidase Inhibitors likes alleged lean prevent the breakdown of Serotonin so more is available SSRIs tend to be the most common cause was because of their widespread use while monoamine oxidase Inhibitors tend to produce the more severe cases other medications include serotonin noradrenaline reuptake it is tricyclic antidepressants serotonin modulators and tryptophan supplementation as it is converted and leads to serotonin formation opioids amphetamines and cocaine also increase serotonin release serotonin is found mostly in the gastrointestinal system it is carried by platelets and also exerts a acts on the central nervous system within the CNS it has rules in attention mood sleep cognition and thermoregulation in the other systems it is involved in vasoconstriction gastrointestinal motility uterine contraction and..." Learn more about your ad choices. Visit megaphone.fm/adchoices

"...Serotonin syndrome also known as serotonin toxicity is a potentially life-threatening condition due to excessive serotonin levels in the body this can come from using the medication as a therapy due to drug interactions recreational drug use or even intentional overdoses the end result is an increased in the amount of serotonin in the synaptic cleft able to bind serotonin receptors, for example, selective serotonin reuptake Inhibitors like Citalopram inhibit the reuptake of Serotonin into the presynaptic neuron meaning more is available to bind the postsynaptic receptors monoamine oxidase Inhibitors likes alleged lean prevent the breakdown of Serotonin so more is available SSRIs tend to be the most common cause was because of their widespread use while monoamine oxidase Inhibitors tend to produce the more severe cases other medications include serotonin noradrenaline reuptake it is tricyclic antidepressants serotonin modulators and tryptophan supplementation as it is converted and leads to serotonin formation opioids amphetamines and cocaine also increase serotonin release serotonin is found mostly in the gastrointestinal system it is carried by platelets and also exerts a acts on the central nervous system within the CNS it has rules in attention mood sleep cognition and thermoregulation in the other systems it is involved in vasoconstriction gastrointestinal motility uterine contraction and..." Learn more about your ad choices. Visit megaphone.fm/adchoices

https://302.buzz/PM-WhatAreYourThoughtsDr. Brooks Keeshin, a triple-board trained child psychiatrist with a focus on trauma, shares his journey into child psychiatry, and discusses the idea of it being a subspecialty of pediatrics. The conversation leads to a discussion on the role of pediatricians in prescribing psychotropic medication and the importance of identifying and recognizing mental health concerns in children. Dr. Keeshin highlights the pitfalls of thinking about mental health as a catch-all, and reminds pediatricians to consider individual diagnoses to guide treatment options. He also points out that psychotherapeutic interventions are usually at the top of the list, and that medication is only one consideration. Get your pencils out…. You'll want to take notes… [00:33 -13:56] The Importance of Identifying Mental Health ConcernsIdentifying mental health concerns should begin with listening to the family's concerns and the child's or adolescent's voice.Using measurements such as universal screening or targeted screeners can help inform the differential diagnosis.It is important to move away from the thinking that mental health is a catch-all, and instead focus on individual diagnoses that will guide treatment recommendations.Early identification and treatment of mental health concerns can improve outcomes and prevent future problems.Having a process to rule out other contributing factors to distress, such as adjustment disorders, can lead to more accurate diagnoses and effective treatment.[13:57 - 26:01] Choosing Treatment Options for Pediatric Anxiety The importance of getting a full picture of the child's symptoms, including using screeners such as SCAREDConsidering evidence-based interventions for pediatric anxiety, such as anxiety-focused CBT or SSRIsCombination therapy with psychotherapeutic intervention and SSRIs may offer the best chance of complete remissionSSRIs such as Fluoxetine, Sertraline, and Citalopram have the greatest evidence base and experience in youthAssessing the level of impairment and degree of symptoms in making a decision about medication vs. psychotherapeutic intervention[26:02 -38:10] Addressing Anxiety Symptoms in Traumatized KidsStepped approach involves addressing other contributing factors before using SSRIsEnsure physical safety of environment before trauma-focused therapyAddress sleep first as chronic insomnia can drive anxiety symptomsMaximize other interventions like social determinants of health and trauma therapy before giving SSRIsAggressively titrate SSRIs to effective doses for robust response[28:11 - 51:33] Improving Access to Expert Child Psychiatric CareImproving access to comprehensive psychiatric evaluations by child psychiatrists is essential for identifying children with severe psychiatric needs.The limited number of child psychiatrists means better triage is needed to ensure the most severely impacted children receive the necessary care.Educating child psychiatrists about the comfort levels and limitations of ongoing psychiatric treatment in primary care can be helpful in improving collaboration.Consider outpatient programs or day treatment programs for kids after inpatient treatment to help them prepare for a return to their normal life.Consider partnering with primary care if it would be more appropriate for the child in the long term.[51:34 - 59:59] Closing segment TakeawayLinks to resources mentioned on the...

In this episode, Dr. Zach April returns to review the SSRI's. These are some of the best treatment options for mood. We talk about what to expect in general with these medications and review some of the individual medicines including sertraline (Zoloft), fluoxetine (Prozac) and escitalopram (Lexapro) to name a few.  A disclaimer, we're providing general guidance but everyone is different and you should always discuss with your health care professional management of any disease and therapy before trying anything you discover from a source on the internet (including this podcast)

Hören statt lesen: Chefredakteurin Julia Pflegel hat den Artikel zum Wirkstoff Citalopram aus unserer Serie Fresh-up vertont. Hören Sie gleich mal rein! (6:11 Min) https://www.das-pta-magazin.de/service-und-mehr/heftarchiv/artikel/serie-fresh-up-citalopram-3205703.html

Dr. “So Good” SherwoodWEBSITE: http://doctorsogood.com-------------------------------------------The main aim of treatment with antidepressants is to relieve the symptoms of severe depression, such as feeling very down and exhausted, and prevent them from coming back. They are meant to make you feel emotionally stable again and help you to follow a normal daily routine.Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed type of antidepressant and include: Fluoxetine. Citalopram. Sertraline.Serotonin in your brain regulates your mood. It's often called your body's natural “feel good” chemical. When serotonin is at normal levels, you feel more focused, emotionally stable, happier and calmer. Low levels of serotonin are associated with depression.Alternatives - Antidepressants•Talking therapies. Cognitive behavioral therapy. ...•Exercise. Research suggests that regular exercise may be a more effective treatment for mild depression than antidepressants. ...•Self-help groups. Talking through your feelings can be helpful. ...•Consistent sleep•Social media monitoring Supplements St. John's wortAshwagandha 5-HTPFull spectrum hemp (CBD)B6Amino acidsOmega 3 fatty acids DDHEA -------------------------------------------TO WATCH ALL FLYOVER CLIPS -https://banned.video/playlist/622553248186d152c5d07f5dSPONSORS FOR TODAY'S VIDEO►  ReAwaken America- text the word EVENTS to 40509(Message and data rates may apply. Terms/privacy: 40509-info.com)►  Kirk Elliott PHD - http://FlyoverGold.com ►  My Pillow - https://MyPillow.com/Flyover►. Z-Stack - https://flyoverhealth.com Own Your Own Business As An Option To Avoid The Jab- http://FlyoverCarpet.com https://TipTopK9.com/Want to help spread the Wake Up • Speak Up • Show Up -https://shop.flyoverconservatives.com/-------------------------------------------Follow our Social Media so we can be best friends

Dr. “So Good” SherwoodWEBSITE: http://doctorsogood.com-------------------------------------------The main aim of treatment with antidepressants is to relieve the symptoms of severe depression, such as feeling very down and exhausted, and prevent them from coming back. They are meant to make you feel emotionally stable again and help you to follow a normal daily routine.Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed type of antidepressant and include: Fluoxetine. Citalopram. Sertraline.Serotonin in your brain regulates your mood. It's often called your body's natural “feel good” chemical. When serotonin is at normal levels, you feel more focused, emotionally stable, happier and calmer. Low levels of serotonin are associated with depression.Alternatives - Antidepressants•Talking therapies. Cognitive behavioral therapy. ...•Exercise. Research suggests that regular exercise may be a more effective treatment for mild depression than antidepressants. ...•Self-help groups. Talking through your feelings can be helpful. ...•Consistent sleep•Social media monitoring Supplements St. John's wortAshwagandha 5-HTPFull spectrum hemp (CBD)B6Amino acidsOmega 3 fatty acids DDHEA -------------------------------------------TO WATCH ALL FLYOVER CLIPS -https://banned.video/playlist/622553248186d152c5d07f5dSPONSORS FOR TODAY'S VIDEO►  ReAwaken America- text the word EVENTS to 40509(Message and data rates may apply. Terms/privacy: 40509-info.com)►  Kirk Elliott PHD - http://FlyoverGold.com ►  My Pillow - https://MyPillow.com/Flyover►. Z-Stack - https://flyoverhealth.com Own Your Own Business As An Option To Avoid The Jab- http://FlyoverCarpet.com https://TipTopK9.com/Want to help spread the Wake Up • Speak Up • Show Up -https://shop.flyoverconservatives.com/-------------------------------------------Follow our Social Media so we can be best friends

Wie schafft man es, sich der eigenen Depression zu stellen und gleichzeitig einen Song zu schreiben, der nicht traurig ist? Der Berliner Musikerin Christin Nichols ist es gelungen. In Tracks & Traces erklärt sie, was Gary Newman, Nora Tschirner und Blumenwiesen damit zu tun haben. Hier entlang geht’s zu den Links unserer Werbepartner: https://detektor.fm/werbepartner/tracks-traces Early Access und exklusive Inhalte von Tracks & Traces bei Patreon: https://patreon.com/tracksandtraces >> Artikel zum Nachlesen: https://detektor.fm/musik/tracks-traces-christin-nichols

Wie schafft man es, sich der eigenen Depression zu stellen und gleichzeitig einen Song zu schreiben, der nicht traurig ist? Der Berliner Musikerin Christin Nichols ist es gelungen. In Tracks & Traces erklärt sie, was Gary Newman, Nora Tschirner und Blumenwiesen damit zu tun haben. Hier entlang geht’s zu den Links unserer Werbepartner: https://detektor.fm/werbepartner/tracks-traces Early Access und exklusive Inhalte von Tracks & Traces bei Patreon: https://patreon.com/tracksandtraces >> Artikel zum Nachlesen: https://detektor.fm/musik/tracks-traces-christin-nichols

Wie schafft man es, sich der eigenen Depression zu stellen und gleichzeitig einen Song zu schreiben, der nicht traurig ist? Der Berliner Musikerin Christin Nichols ist es gelungen. In Tracks & Traces erklärt sie, was Gary Newman, Nora Tschirner und Blumenwiesen damit zu tun haben. Hier entlang geht’s zu den Links unserer Werbepartner: https://detektor.fm/werbepartner/tracks-traces Early Access und exklusive Inhalte von Tracks & Traces bei Patreon: https://patreon.com/tracksandtraces >> Artikel zum Nachlesen: https://detektor.fm/musik/tracks-traces-christin-nichols

On this episode, we hear from Denise Collins, whose husband, John, died in 2018, nine days after going on the antidepressant Citalopram, better known in the United States as Celexa. Earlier this year, her book, What Happened To John?: A memoir of enduring love, mental health, and suicide, was released and is available now in paperback and for Kindle. Denise spent three years researching, writing, and doing her best to recover following the tragic death of John and her experience of becoming a widow. The book opens on what Denise calls Day Zero, Monday, the 29th of October, 2018, a day that began "quite unremarkably," she says, but later that day, two uniformed police officers appeared at her front door. "In that moment," she writes, "I was blissfully unaware that life as I knew it had ended and that a living nightmare was about to begin." Her website, denise-collins.com, is aimed at what she terms "corporate clients." She coaches female executives on developing their authentic leadership style and building a sustainable work/life balance. Her specialties are: Guiding People In Discovering and Celebrating Their Unique Personal Power (UPP©) Supporting Those Navigating Life After Loss and Teaching Resilience And How To Embrace Change.

En 2017 au Québec, les troubles neurocognitifs (TNC) touchaient près de 30% des femmes et 23% des hommes âgés de 85 ans et plus. Le pharmacien peut contribuer à reconnaître les signes des TNC et proposer des traitements, pharmacologiques ou non, pour gérer les manifestations des TNC. RÉFÉRENCES Porsteinsson A P, Drye L T, Pollock BJ et coll. Effect of Citalopram on Agitation in Alzheimer's Disease – The CitAD Randomized Controlled Trial. JAMA 2014 Feb 19; 311(7): 682–691.

En este episodio de SOS, Rafa le responde preguntas a Jorge, Ale, y Estefanía. Manda tus preguntas con una nota de voz al +52 55 6540 5599 para que salgan en un proximo episodio de SOS. También puedes usar esta liga: https://wa.me/5215565405599 Síguenos en @sonoropodcast en todas las redes sociales.

Does SARS-CoV-2 infection have a lasting impact on brain structure? Find out about this and more in today's PV Roundup podcast.

Hyponatriämie Hallo Freunde der klinischen Notfallmedizin und im Jahr 2022 geht es weiter. Hoffentlich lässt es meine Auslastung zu regelmäßige Podcasts zur Verfügung zu stellen. Zusatzmaterial: Algorithmus Hyponatriämie Patientenpräsentationen Schwindel Oma Symptome: Dysäquilibrium seit Tagen schlimmer werdend Vormedikation: Ramipril 5 1-0-1 Amlodipin 5 1-0-1 Chlorthalidon 50 1-0-1 Citalopram 20 1-0-0 Mirtazapin 30 0-0-1 BGA ven."BwZemCAST #23" weiterlesen

Citalopram is also known by the brand name Celexa. It is an antidepressant and a selective serotonin reuptake inhibitor (SSRI). The tablet come in a 10 mg, 20 mg, and 40 mg strength and is also available as a 10 mg/5 ml solution. In adults and pediatrics it can be used to treat both major depressive and obsessive compulsive disorder. There are other off-label indications in children but the only approved use is in adults for major depressive disorder. The treatment range for treating major depressive disorder in adults is 20-40 mg PO qd with a max of 40 mg/day. There is literature with a max of 60 mg/day for OCD but 40 mg/day is the most commonly accepted max dose. The onset of action and benefits for patients are typically seen within the first 1-2 weeks with continued improvements through weeks 4-6. The medication half-life is around 24-48 hours with a duration of action being the same. There is a black box warning for suicidality with the greatest concern for children, adolescents and young adults. The risk does appear to decrease in adults >24 years of age and in the elderly >65 years of age. The medication should never be stopped without approval from the prescriber even when feeling well. Go to DrugCardsDaily.com for episode show notes which consist of the drug summary, quiz, and link to the drug card for FREE! Please SUBSCRIBE, FOLLOW, and RATE on Spotify, Apple Podcasts, or wherever your favorite place to listen to podcasts are. The main goal is to go over the Top 200 Drugs with the occasional drug of interest. Also, if you'd like to say hello, suggest a drug, or leave some feedback I'd really appreciate hearing from you! Leave a voice message at anchor.fm/drugcardsdaily or find me on twitter @drugcardsdaily --- Send in a voice message: https://anchor.fm/drugcardsdaily/message

A new randomized trial suggests that the efficacy of antidepressants for the treatment of bipolar depression is no greater than placebo. This tips the meta-analytic balance scale, which already pointed in this direction. Faculty: Jim Phelps, M.D. Hosts: Jessica Diaz, M.D.; Flavio Guzman, M.D. Learn more about Premium Memberships here Earn 0.5 CMEs: Quick Take Vol. 26 Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial

The one thing that strikes me each morning is that how quickly my moods can change and that I shouldn't trust my feelings. I'm not sure where I read it, but someone mentioned that hunger is like a toddler, always needing something. I seem to have a house full toddlers. I want coffee, I want quiet, I want food, I want media. I want. Therein lies the problem. I want. Even if you kick your worst habit, new desires still find their way into your head. The Buddhists almost have my problem nailed down, since the cause of all suffering does seem to stem from desire. However, there is one thing lacking in the Buddhist answer to the problem of suffering, and that is what the divine person of Jesus presents as a better answer.The problem is this: if Jesus is who he said he is, then we would be insane not to follow him. If he's not who he said he was, then he was insane and deserves not a second look. Tim Keller mentioned this in a podcast and reminded me of this dilemma. And I need to be reminded over and over, because this is at the center of why I was a religious “None” for so long. This either/or scenario that Jesus presents is hard to handle. One way or another we have to make a choice, that either Jesus told the truth or he didn't. The default choice is doubt and indifference, that he is not the son of God and the Resurrection did not happen. This is the The Matrix red pill/blue pill scenario, but this is a more important decision than what the modern conspiracy theorists are using this metaphor to sell. Decide that it is a lie, and you wake up each day and ignore the story. He either rose from the dead, or he didn't, right? This is the question that must be answered by everyone, like it or not. If we do nothing, the default position of doubt is then our selected choice. With this decision, he is lying and it's all a hoax.Well, I spent two decades believing that he was lying. That didn't work out very well for me as I chased so many dead ends. In terms of worldly goals, it worked out fine, great actually, but my soul remained empty through those years. I was spiritually dead. I imagined that I was alive and righteous and “connected” on the internet, but my heart was flatlined. So then I had to slink back and reconsider which pill to take once again. Taking the other pill is much better. Truth be told, I was able to stop taking other kinds of pills (see: Citalopram) once I decided that he was not lying. That alone to me was stunning, absolutely stunning, and I wonder how many others' mental health would improve if they just gave it a shot. The main difference is that one pill removes meaning from life, and the other pill grants meaning to life.I know that exercise boosts my mood and fixes me for a bit, but after pursuing various goals of fitness, I know that fitness alone is primarily for my ego, like any other pursuit of pleasure, not for deep fulfillment. I do find the discipline of exercise far better than old habits, like drinking or watching TV or scrolling on websites. Yeah, those really don't help much of anything in terms of the heart. How many times have I sat on the couch late at night after watching some TV series or movie only to go to bed feeling like I just wasted the evening? Entertainment is like Cinnamon Toast Crunch; so good to consume, but ultimately leaves me empty. Both are best enjoyed in moderation and kept below the more important “Five F's” that I will explain in a minute.The year of the pandemic allowed me ample time to consider what is important, and I am grateful for the space that opened up to find my way back to faith. I see triathlons and marathons as a good goal, but now with my ordering of life changed, fitness no longer takes precedence. Before the pandemic, I saw fitness as this high moral good, a righteousness in itself. I felt like it washed me clean somehow, that through my registration I had purchased a modern indulgence for my soul. But now I see that fitness must fall lower, as follows, in my Five F's:FaithFamilyFriends/Fellowship/FraternityFitnessFinancesAny deviation from that order means I am out of order, like a vending machine that doesn't vend. Thus the trick is remembering this order, especially when I want to go on a two hour bike ride or 10 mile run, or when I want to binge a TV show on Netflix.What I want is often wrong. Learning this is easiest by getting your butt kicked around in life. If my faith or my dedication to family fades, or if I neglect friendships, then this will mean I have elevated fitness over those higher F's. I have done that a lot in my life and I can see the wake of wreckage it leaves. If my marriage comes after anything like drinking or swimming or coaching, then I'm off track. What's clear to me is that this ordering of F's is right. I want to get out for a run today, a brief one, because faith, family, and friends have commitments already. Running is an action done for myself and my ego, but it does help boost the other F's. This is the tightrope to walk, where choices I make tell me where the priorities sit. Fitness helps improve those Faith and Family parts of life, so there is no reason to pretend that all acts done for the ego is somehow bad. I am not a desert monk. No, I'm not nearly as cool as St. Anthony of Egypt. The key of the order is to remember that items lower in the list are not by themselves inherently bad. They are good. But they must never bubble up to the top and become the highest good, the summum bonum, of my life. That is when the title of this blog comes into play: Why Did Peter Sink? Because he was out of order on the Five F's. But simpler still, the Faith “F” fell out of first place.There is a way to help keep this order in place, too. There's a three step recipe described by Word on Fire that seems to help me screw this order to the wall, and it even acts as a good standalone prayer.Finding the Center - Christ must be at the center of my life.Knowing I am A Sinner - There is a dysfunction that I cannot fix by myself.Realizing My Life is Not About Me - Charity and volunteering is the way, and whenever I am thinking of myself, there's a pretty good chance I'm looking away from God.I would add a fourth to that and say: 4. Stop looking for approval from anyone but Jesus. Am I feeling agitated by something in this world? If so, my addiction to self is returning. Turn off the computer or phone and return to step 1.Every run, swim, or bike ride that I do alone can become a time of reflection and even prayer. That I know, as I often go to that “chapel in the heart” anyway while running or biking. I don't know who to thank for this idea, (maybe Ephraim of Syria, I don't recall) but I go there quite often when the world is swirling around me.I can't tell you how many times I have gone to that chapel while coaching, when the chaos starts to swirl. If you want to see a depiction of hell's Furies in modern times, attend a youth sports tournament championship game that has gone into overtime. There you will witness a complete disorder of priorities. I'm not talking about the the children, I'm talking about the adults.The projection of desire by parents onto kids is something that I could elaborate on, oh I would guess, for a few weeks. The reason people are so into children's sports is because they lack something. They need approval, they want love, but they desire above all honor. None of us are about to be called up to war where we can take up our shield, for God and country, like in The Battle of Maldon, where the Anglo-Saxons got rocked by the Vikings but went down in a blaze of glory. But we are still yearning for that experience and youth sports is the proxy experience. I can watch the change on a parent's face as bloodless victory nears. I feel like if I threw a T-Bone steak toward their folding chair they would ravage it like a starving wolf in the corner of the gym. For glory and honor, for the victory of our ego over some random parents from another suburb. Following through with The Battle of Maldon, if I replace Æthelgar and Godric in the verse below with people I know it would work today as well as a millenium ago:So Æthelgar's son emboldened them all,Godric to the fight. Often he let go of his spear,the slaughtering spear flying into the Vikings,so he went forth, first in that crowd,hewing and maiming, until he perished in the battle.Godric fought and died for England and became a legend. Little Johnny fights under the mantle of the local gas station or realty office. That ribbon or medal may be cheap in terms of money, but in today's world is sought like the Ring of Power, as we seek validation in that idol, until the next tournament, next week, on a Sunday usually, where the whetting of the appetites for honor starts all over again.I've watched parents explode in rage, not always at the opposing team, or the referee, but often at their own child. That's when you can see the truth spill out on how sports actually affects their lives. It's embarrassing and everyone looks away. Funny how we never approach and ask someone, “What is the order of priority in your life? Is youth sports the highest good, above your family or faith?” That would irritate a lot of people, but might be beneficial in the long run for challenging their notions.But in that moment when others are losing it, that's when the chapel within is ready, like a 24-hour neon sign in a bar flashing the words: “Happy Hour”. I can go there and watch the madness happening around me and I ask myself, “Why Did Peter Sink?”Literally, I do this. If I can extract myself from getting caught up in the moment, I definitely do this. I have several seasons of using this tactic now in the dugout and on the basketball bench. There's no soundtrack of Ave Maria playing, no cinematic experience, no bathos like the Hallmark Channel movies, there is only a single question to ask myself, to re-center on what is most important so that I avoid going adrift and sinking, to put fear aside and find that radical trust in faith again.Lest you think I feel sports are bad, I do not. The benefits of sports outweigh the negative, as the kids make friends, they exercise, they understand what teamwork means, they work toward a goal, and they celebrate the ups and downs of wins and losses. Overall, the kids learn many of life's lessons through sports. It's just the adults that are insane, and I'm as guilty as anyone of elevating it to an excessive height in the priority of things. I still recall the devastation I felt in the first seasons when a last second shot crushed our hoop dreams. This was actually one of those moments of realizing the disorder of my life, when a group of kids making a basket could cause my sense of the world to crumble. As a Minnesota Vikings and Golden Gophers fan, I should never have fallen into this trap. I should have known well in advance that hanging my ultimate hopes and mood on a sporting event would leave me cold and in the fetal position, yet I still let youth sports feed my ego vicariously to the point where it gave me a false sense of value.The same goes for fitness. Getting in shape so easily converts from making a self-improvement into a self-love, and then quickly slides over into lust or pride, and I'm sorry to say, a kind of self-worship. Need evidence? Have you heard of Instagram? You know what I'm talking about. It all started with simple gym selfies. Now the clothes appear to be painted into every crack and crevice of the human body, leaving so little to the imagination that Jane Austen's Victorian readers heads would have have exploded upon eye contact. The pursuit of happiness through fitness or sports or knowledge or drinking - it's all the same. All of it. It may make you happy for an hour or two, maybe a week, maybe even a year or five years. But eventually it will fail, and then you will wonder why. I certainly scratched my head and wondered why this thing or that thing didn't satisfy, and usually, before long, rather than examine why, I would move on to another thing and expect the permanent solution to happiness to be there. I wondered why.And now I can tell you why. It's not because any of those things are specifically bad in themselves. It is because all of those things were not God. What happens is that there's a thing I wanted, and if I got it, I was soon disappointed, and if I didn't get it, I was soon disappointed. And then I was angry or upset or depressed.Why?Because it wasn't God.Thomas Merton said, “People may spend their whole lives climbing the ladder of success only to find, once they reach the top, that the ladder is leaning against the wrong wall.”Anything that you put highest in your life that is not God has a shelf life of supermarket milk; it's good for a while then turns rotten. If you want to get off that treadmill of the pursuit of happiness, if you want a way to be happy not for a week or month or year, then give faith a try - a real try. Do it for a year. For all the quack diets and depression pills and exercise equipment we buy, what would hold you back from trying something that is free?Exercise in general, without question, is good. It's very good. The mental assist that physical exercise gives me helps with the second and third F's, Family and Friends. I believe there is a way to weave this all together, but the danger here is that the self, not the Higher Power, is driving the decision. Pride (A.K.A. honor) is a many-headed hydra that comes back to me in a thousand forms. Cut one head off, and two grow in its place. If I aim to build habits around a Christ-centered life, such that I can deal with whatever challenges lie ahead, I can remain disciplined in faith and not fooled by the shadow-puppets of this world that beckon us toward the four Big Empties: pleasure, honor, wealth, and power. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.whydidpetersink.com

Hoy revisamos las generalidades del uso de antidepresivos, específicamente los inhibidores de recaptura de monoaminas como los inhibidores selectivos de recaptura de serotonina, inhibidores selectivos de recaptura de noradrenalina y serotonina, los de noradrenalina y dopamina y los antidepresivos tricíclicos.Abarcaremos desde su uso en depresión y ansiedad, hasta su uso en neuropatía diabética, dolor neuropático, migraña, fibromialgia y obesidad.Visita nuestra tienda en línea para comprar nuestros libros y material educativo:https://bit.ly/3i6eAnGCheca el video aquí: https://youtu.be/M11EZn1Y9NgSi necesitas una consulta nos puedes encontrar aquí:http://bit.ly/3aUSt12Unete al equipo de Mecenas en YouTube desde 1 dolar al mes: http://bit.ly/2O1AtsX o nos puedes hacer una doncación única en: https://www.paypal.com/donate?hosted_button_id=2ENWQ7V289PBESupport the show (https://www.paypal.com/donate?hosted_button_id=2ENWQ7V289PBE)

Der Klinisch Relevant Podcast liefert Ärztinnen und Ärzten, sowie Angehörigen der Pflegeberufe und medizinischer Fachberufe wie Physiotherapie, Ergotherapie und Logopädie kostenlose und unabhängige medizinische Fortbildungsinhalte, die Du jederzeit und überall anhören kannst.

You  are NOT going crazy.  In fact you are doing brilliantly given the fact that you live in a world that doesn't seem to understand what you're going through.  There are real chemical changes going on in the brain from peri to post menopause which cause us to forget words,  feel more anxious and lose confidence.   You might FEEL crazy, but you are not GOING crazy, and you're definitely not to blame for the way you feel.  In today's episode, I explain why.  But, here's a clue.   The effect of declining sex hormones actually starts in the BRAIN, and as a result, many people can start to feel the onset of menopause mentally first, not physically, as previously thought. Your prescription for Citalopram might be well meaning from your 30 year old male GP, but it might not be getting to the root.  So if you want more clarity and understanding about what's actually going on (I'm going to go into some detail here) then this episode is for you.  And if you're ready to get some advice about what to do next, this episode is for you.   As a Gen X person, I know you feel like you are doing all the work right now, but hang in there because knowledge is power. Sally's Links [Free] Relaxation Hypnosis Recording:  https://bit.ly/relaxationwithsally [Free] How to Make Sleep Your Super Power https://www.sallygarozzo.com/optinsleepwebinar [Free] Sleep Hypnosis Recording: https://bit.ly/sleephypnosisrecording How to Create Phenomenal Self Esteem [£47]:  https://www.sallygarozzo.com/selfesteem Rapid Transformational Therapy [£447]: https://www.sallygarozzo.com/rtt Menopause Solution Sessions [£147]: https://www.sallygarozzo.com/mentoringMenopause Holistic and Wellbeing Practitioner [£111]:  https://bit.ly/menocourse Cold Water Therapy Practitioner [£111] https://bit/ly/coldwatertherapy  Instagram:  https://www.instagram.com/sallygarozzomindmentor Facebook:  https://www.facebook.com/sallygarozzomindmentor Be a Podcast Guest:  https://singingandhypnosis.as.me/podcastinterview 

What is the prevalence of underlying medical conditions associated with severe COVID-19 in cancer survivors? Find out about this and more in today’s PV Roundup podcast.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.28.262550v1?rss=1 Authors: Livermore, J. J. A., Holmes, C. L., Moga, G., Adamatzky, K., Critchley, H., Garfinkel, S., Campbell-Meiklejohn, D. Abstract: Interoception is the signaling, perception, and interpretation of internal physiological states. A causal link between serotonin and interoception was tested by a within-participant, crossover, placebo-controlled study. Forty-seven healthy human volunteers were tested on and off a 20mg oral dose of the selective serotonin reuptake inhibitor (SSRI) citalopram. For each randomly ordered session, participants made a series of judgements about the synchrony of their heartbeat to auditory tones and expressed confidence in each judgement. Citalopram enhanced insight into the likelihood that a correct interoceptive judgement occurred, driven primarily by increased confidence in correct judgements. This effect was independent of measured physiological and subjective effects of the drug and greater than a null effect on insight into exclusively exteroceptive performance on a visual task. This finding provides a foundation for considering effects of serotonin on cognition, emotion, and behaviour in terms of higher order processing of interoceptive events. Copy rights belong to original authors. Visit the link for more info

Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD. How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast. Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast. Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.12.147876v1?rss=1 Authors: Villani, C., Sacchetti, G., Carli, M., Invernizzi, R. W. Abstract: Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Repeated administration of 10 mg/kg fluoxetine fully rescued rotarod deficit in Mecp2 Het mice regardless of age, route of administration or pre-training to rotarod. The motor improvement was confirmed in the beam walking test while no effect was observed in the hanging-wire test, suggesting a preferential action of fluoxetine on motor coordination. Citalopram mimicked the effects of fluoxetine, while the inhibition of 5-HT synthesis abolished the fluoxetine-induced improvement of motor coordination. Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. No sex differences were observed in the ability of fluoxetine to desensitize 5-HT1A autoreceptors upon repeated administration. These findings indicate that fluoxetine rescues motor coordination in Mecp2 Het mice through its ability to enhance brain 5-HT and suggest that drugs enhancing 5-HT neurotransmission may have beneficial effects on motor symptoms of RTT. Copy rights belong to original authors. Visit the link for more info

It's been a productive day. I've been listening to Brian Rose's interview with Ice-T.I've been listening to a lot of music recently and enjoying the Facebook 10 Albums meme.Here are the things I talk about today. I'm having problems with my injured leg. I'm experiencing dizzy spells because of cutting back on the Citalopram. Morning routine. Banking in Xero. Business planning. Studying on SMU with Rachel Pedersen The power of positive thinking. See this episode on YouTubehttps://youtu.be/c6gio0K4-bc★ Support this podcast on Patreon ★

JAACAP March 2020: Contributing Editor Dr. John Erik Leikauf interviews Dr. Kenneth Towbin on the effects of adding citalopram to methylphenidate in the treatment of chronic severe irritability in youth using a double-blind randomized placebo-controlled design.

JAACAP March 2020: Contributing Editor Dr. John Erik Leikauf interviews Dr. Kenneth Towbin on the effects of adding citalopram to methylphenidate in the treatment of chronic severe irritability in youth using a double-blind randomized placebo-controlled design.

Avec Dalila Awada, Lili Boisvert, Vanessa Destiné, Selma Bennani et Elkahna Talbi aka Queen Ka.

There continues to be widespread concerns over shortages of critical psychiatric drugs for mental health patients in Gautend and across the country. The drugs in short supply are (include Fluoxetine and Citalopram) both critical inhibitors that ease symptoms of moderate to severe depression. Mental health patients are being told that essential drugs are in short supply or inadequate in supply and told to come back later in government hospitals and clinics.

Está entregue, em sua casa, a Sexta Básica dessa quinzena! No pacote de hoje: Fluoxetina, Paroxetina, Citalopram, Escitalopram, Sertralina, afeto e amor próprio na medida certa! Nesse Setembro Amarelo, oferecemos a todos o alimento necessário para que a mente não caia nas armadilhas da depressão. SAC: Mande suas sugestões de produtos para as próximas caixas e reclamações sobre produtos estragados para: contato@sextabasica.radio.br (Obs.: Não aceitamos devoluções.) Redes sociais: Instagram: @sextabasicapodcast @odilon_silva1 @bnfernandes92 @jonys_macedo @rafafontanari Twitter: @Jonys_macedo @odihsilva @bnfernandes92 @rafafontanari

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started!    Tony: my goal is longevity n antiaging.. i practice daily mma jiu jits su and kickboxing.. i am active. i just want great health. tell me what is the protocol for me to have a very healthy all around body in n out. I'm 29yrs old. Molly: Dear doctor Cabral,I’m a health and wellness coach, and listen to your podcast every day. I have to say, I think I learned more from you than I ever did with my other courses, so I want to thank you for that. Now there’s something I’m struggling with personally and haven’t been able to get to the bottom of it. I really hope you can help. I’m a healthy, 40 year old woman, vegan, meditating every day, exercising 6 days a week, doing 18:6 intermittent fasting. I fall asleep easily around 9.30pm, but wake up every night between 3 and 4 pm, am wide awake and just can’t go back to sleep. In the end I doze off an hour or two later, usually just before alarm goes off at 6am. I wake up so tired, and am exhausted and have brain fog throughout the day. Do you have any idea what might be causing this? It would be wonderful if you could give me some tips and ideas what to look for. Thank you so much in advance, much respect, Molly Maci: Hi Dr. Cabral. I recently discovered your podcast and have been listening to several episodes each day. The work that you do is inspiring, thank you! I am a 23 year old female and I have a number of issues going on and would like your guidance on where to begin. I'm currently in school pursuing my Master's in Social Work and due to the intense program schedule, I'm not working and unfortunately, cannot afford lab testing at this time. Both sides of my family have a history of heartburn and acid reflux and my dad is being treated for Barrett's Esophagus. When I started college, I began experiencing heart burn and was put on Omeprazole. I'm no longer taking the Omeprazole as my symptoms have since subsided, but I often get this feeling of having liquid in the back of my throat. There are no burning sensations or pain, but nothing seems to help. I also struggle with constipation and bloating, however, I've been following your recommendation of lemon water to start the morning and using your smoothie guide to try following "liquid before lunch," for the past week. In addition, I have struggled with cystic acne and have been on birth control pills for 7 years and also take 100mg of Spironalactone daily. Lastly, I was diagnosed with anxiety in September of 2018 and take Citalopram daily for that as well. In listening to several of your shows on leaky gut, acne, and anxiety, I've realized that many of my issues could be stemming from my gut. I would like to get off all my medication (other than birth control), but need to know where to start in the process of doing so. Overall, I live a healthy lifestyle, exercising 5-6 days per week (both resistance training and some HIIT/Aerobic exercise), I teach one yoga class each week, and I eat a diet full of protein (however, learning that I probably need more fish and Omega-3's from your podcasts), fruits, and vegetables. I'm 5'11" with a thin stature and as you've discussed, it's more difficult for me to put on muscle than it is to lose fat. I'm planning to do your 21 day detox (likely will have completed by the time this appears on the show), but will wait to begin until I return from Mexico at the end of March. Thank you so much for all that you do and I appreciate you taking the time to provide me with recommendations! Susane: Hi! I have some questions around cherry angiomas. I've always had one or two major ones my whole life, they have never changed and haven't caused any concerns or thoughts, until now. The last half a year or so they have been appearing everywhere on my body all of a sudden at an exponential rate. This makes me worried as I dont want them as of aesthetic reasons, but also because I am wondering if something is wrong. I am 27 years old. Hence, do you know what causes them? Root cause? Can it be due to heavy metals? Been reading that bromide can cause them. How do you think I should address the problem? Do you think they will disappear by themselves as I find the root cause? What do you specific recommend me doing going forwards? What would you do. Thanks. Cody: Hi Dr. Cabral, My dentist tells me I have slightly receding gums. What causes this and what can be done to stop or reverse this? Thanks, Patrick: Hey dr Cabral hope all is well with you and your family. Been feeling great since finding your podcast about 8 months ago and doing your DNS everyday . Now that summer is coming up my question is about poison ivy, me and my kids ( triplets ) go bike riding a lot on trails in the woods and are on soccer fields a few days a week it seems like me and my one son get poison ivy even if we look at it and then it’s always the same thing go to the doctor get a Creme that never works go back in a week now covered in it and then get a zpac and it clears right up . What can I do to keep it from spreading all over and treat it naturally. Thank you and keep up the great job your doing. Susan: My 85 year old mother is suffering terribly with shingles. Terribly is putting it lightly and it's been for months now! She has been under a Dr's care but it seems like nothing really can be done. He finally took her off of hydrocodone because she was becoming addicted to it. Both my mother and my mother in law are urging my husband and I to get the "shingles shot", they are so worried about us getting the shingles. We are 55 and I personally have never even gotten a flu shot. What are your thoughts about getting the shingles shot? Thank you!   Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/1199 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. 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On a day upon which I find myself once again taking Citalopram tablets to help with my ongoing bout of depression, here's another quick insight into my current bout of depression. I don't normally say this but can I please urge you to listen to the very end, particularly if you know someone that you think might be struggling at present.

Porpoise Crispy Podcast
Volume #8 Episode #1 Citalopram (Celexa, Cipramil) Curated by Megs January 29, 2019         Last of the volume sevens Sister I'm a Poet Morrissey Beethoven Was Deaf Sheets Damien Jurado Caught In The Trees Freedom Of '76 Ween Chocolate And Cheese California Girls The Magnetic Fields Distortion Tibetan Pop Stars Hop Along Get Disowned       Domestication Laura Gibson Goners My Name Is David Dust Congress October 11, 2007 at Public Trust         Forty Dollars The Twilight Singers Powder Burns          Reveal The Rats Fatal Flying Guilloteens Quantum Fucking         Day Glo Hazel Toreador of Love Let's Kill Saturday Night Silkworm You Are Dignified Colleen Joanna Newsome & The Ys Street Band EP      First of the volume eights The pCrispy is only an hour of music so I know you’ve got time to enjoy to these bad asses of the Internets:  The Westerino Show Funkytown Bayerclan Squirreling Podcast Secretly Timid    

What really is the relationship between light, the circadian rhythm and mood? How might modern anti-depressants alter that relationship? We address these questions and more with the help of Associate Prof Sean Cain from Monash University. Dr Moira Junge (Health Psychologist) and Dr David Cunnington (Sleep Physician) host the monthly podcast, Sleep Talk, talking all things sleep. Leave a review and subscribe via iTunesAudio Timeline: 00:00 - 04:48 Introduction 04:48 -33:07 Theme - Rhythm and Blues 04:48 - 25:13 Interview - A Prof Sean Cain - Light, sleep and mood 25:13 - 30:03 Discussion and where to find more information 30:03 - 30:57 Clinical tip: Beware SSRIs in eveningness-types 30:57 - 36:51 Pick of the month: 30:57 - 32:17 Moira - Melatonin for delayed phase 32:17 - 34:16 David - The Science of Sleep- Wallace Mendelson 34:16 - 36:51 Sean - Magnetoreception in birds 36:51 - 38:02 What's coming up in sleep? Next episode: Sleep in depressionLinks mentioned in the podcast:  Assoc Prof Sean Cain - Monash University profile Evening types demonstrate reduced SSRI treatment efficacy- research article in Chronobiology Citalopram increases sensitivity of the circadian system to light - research article in Psychopharmacology Seasonal effective disorder (SADs) - podcast episode Light therapy - blog post Teens and screens - podcast episode Chronotherapeutics for Affective Disorders- Book Melatonin for delayed sleep-wake phase disorder - research article The Science of Sleep- Book by Wallace Mendelson Magneto-receptors in birds - research article Bipolar mood and tidal cycles- research article

WHAT IT IS AND WHAT IT DO MY NON GENDER BINARY MULTI RACIAL BEAUTIFUL FRIENDS. It’s Alex. Man oh man, I wanna get better at this stuff but this show was a mess to pull off. After losing the SD Card and forgetting batteries, sitting in sauce soaked pants , The Intern, Vegeta, and I sat down at our home away from home and had some fun. This is our last show before the HHN meet up and we couldn’t resist heading up a few days early to check it out for you. Fisher was being a kick ass dad but he will be back for our next show we record on Friday. On this show we discuss: On this episode we discuss - Intern is LIT - Alex sans Citalopram is a mess - Weekend round up - Talking Heads/David Byrne - Old people at shows - More than just the hits - Poly Pocket and Mighty Max - The toys that made us a man or woman - Don't at me bro - Vegeta learns he isn't young anymore - Vegeta parties with Gamora and blacks out at another wedding - Other countries do weddings better - Vegeta's wedding almost killed all of Alex's friends - Intern is addicted to HHN - Fighting at football games - Post Malone commercial interrupts the Intern - No easy night for The Intern - Furious Holes - Football Futbol and the culture thereof Love you friends.  See you soon. Big thanks to our friends at Mason Danger Beard Co. who hook us up with some AWESOME beard products!  Enter BYOCB at checkout for 15% off your order. Our newest sponsor is Tin and Taco and we absolutely love it there. Tell them BYOCB sent you. Big thanks to our BYOCB sponsors - Lauren Tewson Photography and Swan Brewing.  Check out our new sponsor, which we call heaven at Tuffy's Bottle Shop & Lounge. We drink. We laugh. We drink. Follow the show on Twitter @BYOCBShow check out BYOCBShow.com.  Subscribe and rate the show on Apple Podcasts.  Be sure to follow us on Instagram @BYOCBShow

The pilot. Episode Zero. In which Tim and I discuss who we are, why we're doing this, and offer embarrassingly desperate pleas for feedback and contact. Also features: • Talking Therapy. A chat with Cognitive Behaviour Therapist Ali Binns on what CBT is and how it can help men modify their behaviour and ease anxiety. • Media Share. Tim recommends an app that can help manage social media compulsion, while I gush about an incredible memoir of depression recovery. Series One coming Autumn 2018. Get in touch:contact@emotionalcripples.com@emcripples (Twitter)Facebook Group: https://www.facebook.com/groups/1707014319375624/ ==SHOW NOTES==Samaritans: https://www.samaritans.org/ Call 116 123 (UK and ROI) Befrienders: https://www.befrienders.org/CALM – the Campaign Against Living Miserably: https://www.thecalmzone.net/ ----- MUSICThe Weathermonger - 'Fourier'The Weathermonger - 'Through The Honeycomb Window'https://soundcloud.com/theweathermonger Sertraline: https://beta.nhs.uk/medicines/sertraline/Citalopram: https://beta.nhs.uk/medicines/citalopram/ Valerie Solanas and the Society for Cutting Up Men: https://www.prruk.org/the-society-for-cutting-up-men-and-the-woman-who-shot-andy-warhol/ 'Sad Steps' by Philip Larkin: https://www.poetryfoundation.org/poems/48418/sad-steps Ali Binns, Cognitive Behavioural Therapist: http://www.alibinns.co.uk/ NLP: https://www.nlpacademy.co.uk/what_is_nlp/ Lanzarote: https://www.lonelyplanet.com/canary-islands/lanzarote Stoicism: https://dailystoic.com/what-is-stoicism-a-definition-3-stoic-exercises-to-get-you-started/ Moment app: https://inthemoment.io/ 'Reasons To Stay Alive' by Matt Haig: http://amzn.eu/6WaNwEm

O is for Orgasm   Welcome to the A to Z of Sex. I'm Dr Lori Beth and I am your host.  We are working our way through the erotic alphabet one letter at a time.  Just a reminder this podcast deals with adult content, so if you don't have total privacy, you might want to put on your headphones.  Today the letter is O and O is for Orgasm.   Orgasm is the climax of sexual activity.  Some believe it is only centred on the genitals.  However, many experience full body orgasm.  Orgasms differ in intensity, length and even location.   Orgasm is often seen as the goal of sexual activity and although orgasm is incredible, the best sex involves being present throughout and enjoying each phase.    Often people present for help because of issues surrounding orgasm, either failure to reach orgasm or in men pre-mature ejaculation.    Many people don't understand the anatomy of orgasm.  Physiologically, the brain and the circulatory system are deeply involved in orgasm in both men and women.  The brain is the centre of sexual excitement and the brain stimulates increased blood flow into the genitals.  The central nervous system fully engages the nerves that feed the genital area which are hooked into the brains reward system and a feedback loop builds until the peak is reached.    Both men and women experience some of the same physiological phenomena.  Blood fills the penis, nipples and lips for men and for women the labia, clitoris, nipples and lips.  Both experience rhythmic pulses during orgasm.  Many women also ejaculate.    There are so many ways to make orgasm happen.   Many women have painfully little knowledge about orgasm when they first start having sex.  I had almost none when I first started having sex.   Sex education didn't include anything about pleasure and unfortunately in many places it still doesn't.  Up to 37% of women are either unable to have orgasm or have extreme difficulty having an orgasm.   All orgasms are not alike.  They can be effected by cognitive state, psychological state and what chemicals are in your body at the time (including hormones, drugs, alcohol, other medications).  Your genitals are enervated by several pairs of nerves and when different combinations are stimulated, you have different sensations.  So – called blended orgasms occur when a bunch of areas in the genital area are stimulated – clitoris, vagina and G-spot for example and each level of sensation is additive so the orgasm is layered, deep and can last longer.  There is such a thing as a cervix orgasm as well!  This can occur through stimulation of the cervix and is known for being extremely intense.    There is such a thing as a nipple orgasm just as orgasms can come as a result of playing with the anus, visual imagery, breasts, auditory stimulation and fantasising. The length of time an orgasm lasts gets longer as you get older (Isn't that a great reason to keep having lots of sex as you age?) Cumming can relieve pain.  Endorphins block pain receptors in the brain and oxytocin (released during orgasm) also suppressive pain and perception of pain.   The types of difficulty women have include: Primary anorgasmia – when a woman has never been able to reach orgasm Secondary anorgasmia – when a woman who previously was orgasmic is now not able to reach orgasm. Situational anorgasmia –when not reaching orgasm is as a result of the situation.   Medications can have a negative effect on the ability or each orgasm.    This includes SSRI antidepressants like Prozac and Citalopram which are notorious for inhibiting orgasm.   The biggest difficulty people have in my experience is letting go.  In order to have an orgasm, you have to let go.  One of the great joys of orgasm is that you cannot control it.  You have to relax and be open to the sensations and let your body, mind, heart and spirit respond to the stimulation and love you are experiencing.   If you have trouble relaxing, try...

We apologize to our listeners for our show being late this week. We are coming to you directly from the Exploring Psychedelics Conference at Southern Oregon University, and preparations and travel have slowed down the release of this week's episode. On Today's Episode of the podcast, Jonathan talks with Jon Bridge. Jon is  a 34 year old father of two. from Canada. The two met through a Facebook Group, The Terence McKenna Experience, thanks to Jon's willingness to share his inspiring story of hope and healing. Jonathan felt called to respond almost immediately after the posting appeared on his feed, and the two connected to share Jon's story. Jon's experience of the failure of standard  psychiatricpharmaceutical drugs  and his journey back to health with the help of psilocybin mushrooms and a clear understanding that the conditions that ailed him for years did not have to be permanent, or simply "managed" with ill-understood collections of molecules. Jon [I was on] daily doses of high strength, high dose pharmaceutical garbage. I was supposed to be a customer for life. Although I have no credentials behind my name I have a story of healing and hope. I had been a long time sufferer of mental illness but thanks to psychedelic medicines I have discovered a new, better self. My journey into psychedelic healing has just begun and I hope to be able to inspire someone to help themselves. Jon's "before" picture, on the let, is dated March 20, 2010, exactly 6 years before the date of his Facebook post..Looking in the eyes, it feels possible to almost see the changed interior landscape behind them. This is a story that our listeners will not want to miss. (None of Jon or Jonathan's remarks should be interpreted as psychiatric advice. Neither is a licensed therapist. Changes in medicines should be done with the partnership of a qualified professional.) Thanks to everyone who "Liked" Psychedelic Parenting on Facebook and helped us reach our goal of 1000 page likes by the end of March. As of 3/31/16 at 11:59pm, we had 1017 page likes! Thanks again to all who clicked, shared or clickshared... And, as always, if you like what you see and hear, please consider a tax-deductible contribution to the work. Help us keep the podcast streaming and the website improving! Click the purple button below to contribute to Psychedelic Parenting via MAPS Click HERE to join our mailing list or become a part of our "Secret" Facebook discussion group. TOPICS AND WEBSITES DISCUSSED IN THIS EPISODE: Exploring Psychedelics Conference Home Page Facebook Page Grateful Meds Dispensary, Talent, Oregon Home Page Oregon Cannabis Connections: "Third Grateful Meds Dispensary Opens in Talent" Pharmeceutical Products Cyprolex (Generic: Escitalopram) Tryptophan Lithium Seroquel (Generic: Quetiapine) Wellbutrin (Generic: Bupropion) Citalopram (Brand Names: Celexa, Cipramil) Divalproex (Valporate) Stopping Psychiatric Drugs  For specific dangers and symptoms and helpful guidelines for coming off psychotropics, see Coming off Psychiatric Medication  Ketamine Erowid.org page WebMD: "Ketamine: The Future of Depression Treatment?" ClinicalTrials.gov: "Rapid Antidepressant Effects of Ketamine in Major Depression" Vice.com: "I Used Ketamine to Treat My Depression" Ketamine Advocacy Network: "Provider Directory" Dextromethorphan ("DXM") Erowid.org: "DXM Vault" Psilocybin Erowid.org: "Psilocybin Mushroom Vault" Vice.com: "What it Feels Like to Treat Depression with Magic Mushrooms" New York Times: "Can Mushrooms Treat Depression?" The New Yorker: "The Trip Treatment" By Michael Pollan Mixing Psilocybin and Cannabis (as Jon describes in his story) Shroomery.org forums: "Cannabis and Mushrooms" Erowid Experience Vaults: "Rendered Eternal, Mushrooms and Cannabis" Santa as Shaman When Santa Was a Shaman: Ancient Origins of Santa Claus and the Christmas Tree  by Tony van Renterghem NPR.org: "Did 'Shrooms Send Santa and his Reindeer Flying?" Reality Sandwich: "Shaman Claus: The Shamanic Origins of Christmas" Plenty of Fish (POF) Free Online Dating Service

Editor's Audio Summary by Edward H. Livingston, MD, Deputy Editor, the Journal of the American Medical Association, for the February 19, 2014 issue

Interview with Constantine G. Lyketsos, MD, MHS, author of Effect of Citalopram on Agitation in Alzheimer Disease

Kendra Grant Malone is the guest. She is the author of two poetry collections, Everything is Quiet (Scrambler Books) and Morocco (Dark Sky Books), the second of which she co-wrote with Matthew Savoca.  Blake Butler says "Kendra Grant Malone contains several hundred people. Likewise, her words seem to protect several hundred other words beneath their giddy, precise calm. Here is a mother and a voyeur and a pervert and a magick-making child, somewhere between them all your brand new old friend, teeming with such heat. Here is language more honest than I could ever be. I suggest you keep it close, warm. I suggest you keep an eye, as if this book had human hands beyond its gorgeous shoulders it would tickle you to death; it would hump your funny tired body, then eat your head for what you’ve seen." And Ben Greenman says "Any book that thanks ‘vodka, cocaine, and Citalopram, for making mood swings bearable and this book possible’ is likely to a strong sense of its own identity, or identities, and Kendra Grant Malone’s Everything is Quiet certainly does. Strong: her use of language, her voice, her commitment to getting it right, even as she’s describing how she frequently gets it wrong. Sense: a good ear, a good eye, an intimate acquaintance with bodies and what (and who) they do. These fifty sexy, thoughtful, and sometimes pained poems do right by sex, love, and sometimes pain, not to mention menstrual blood, greasy hair, funny faces, and watering eyes." Monologue topics: bachelor parties, relief, contradiction, antisocial behavior, strip clubs, Wrangler jeans, fly-fishing. Learn more about your ad choices. Visit megaphone.fm/adchoices

Die Alkoholabhängigkeit ist eine häufig chronisch verlaufende und multifaktoriell verursachte Erkrankung. Aus einer Reihe von Untersuchungen ist bekannt, dass ein signifikanter genetischer Einfluss auf das Risiko einer Alkoholabhängigkeit besteht. Außerdem wurden in den vergangenen Jahrzehnten große Anstrengungen unternommen, biologische Marker und so genannte intermediäre Phänotypen (Endophänotypen) zu identifizieren, die mit dieser Erkrankung im Zusammenhang stehen. Ein wichtiger zentraler Neurotransmitter ist Serotonin (5-HT), der u.a. auch die Regulation von endokrinen Funktionen, wie etwa der limbisch-hypothalamisch-hypophysär-adrenergen Hormonachse (LHPA) beeinflusst. Umgekehrt besteht auch ein Einfluss der LHPA auf die zentralnervöse serotonerge Funktion. Bei Alkoholabhängigen wurde durch vorangegangene Studien über Veränderungen dieses Systems berichtet, die von erhöhten Stresshormonwerten bei Intoxikationen und im Entzug bis hin zu Störungen der Stresshormonantwort (Cortisol und ACTH) auf exogene und endogene Stressoren reicht. Serotonin wird mit einer Reihe von psychischen Störungen, wie Abhängigkeitserkrankungen, Impulskontrollstörungen, Angststörungen und Depression, ursächlich in Verbindung gebracht. Insbesondere impulsive Verhaltensweisen beinhalten ein erhöhtes Risiko für das Entstehen von Abhängigkeitserkrankungen. So tragen Impulsivität als Verhaltensdisposition möglicherweise zu einem früheren Beginn, höherer Trinkmenge und vermehrter Rückfälligkeit bei. Wichtiger Bestandteil des serotonergen Systems ist der Serotonintransporter 5-HTT, der, präsynaptisch lokalisiert, durch den Rücktransport von Serotonin aus dem synaptischen Spalt die Konzentration und Wirkdauer dieses Neurotranmitters erheblich beeinflusst. Dieser Transporter ist der Wirkort von Serotoninwiederaufnahmehemmern (SSRI), zu denen auch Citalopram zählt. Für das Gen des 5-HTT wurde in der Promoterregion eine funktionell relevante genetische Variante (5-HTTLPR) mit 2 Allelen (S und L) berichtet, der sowohl die exprimierte Anzahl als auch die Wiederaufnahmekapazität des Transporter signifikant beeinflusst (S < L). Neuropharmakologische Untersuchungen, so genannte „Challenge - Studien“ mit serotoninagonistisch wirkenden Substanzen, wie etwa Fenfluramin oder p-Chloroamphetamin, berichteten über einen Zusammenhang zwischen der Funktion des serotonergen Systems, einer verminderten endokrinen Responsibilität mit vermehrt impulsivem Verhalten und Craving (Suchtdruck, Trinkdruck) bei Alkoholabhängigen im Vergleich zu gesunden Kontrollen. Der selektive Serotoninaufnahmehemmer Citalopram, der auch in einer intravenösen Applikationsform zur Verfügung steht, ist seit vielen Jahren als Medikament zur Behandlung von Depressionen und Angststörungen in Verwendung. Dieser SSRI hat wahrscheinlich im Vergleich zu bisher verwendeten serotonergen Substanzen den Vorteil der spezifischeren Wirksamkeit am 5-HTT und der besseren Verträglichkeit. Ziel dieser doppelblinden, randomisierten und kontrollierten pharmakologischen Challenge- Studie an Alkoholabhängigen und Kontrollpersonen mit Citalopram 0.4mg/kg Körpergewicht vs. Placebo ist es, die Wirkung dieses SSRI auf impulsives Verhalten und endokrine Responsibilität in Abhängigkeit vom Genotyp des 5-HTTLPR Polymorphismus zu messen. Dabei wurde als primäre Hypothese angenommen, dass Citalopram impulsives Verhalten, erfasst mit dem Continuous Performance Test (CPT), signifikant beeinflusst. Darüber hinaus wurde angenommen, dass die endokrine Responsibilität, erfasst über periphere ACTH Spiegel, durch den Genotyp des 5-HTTLPR Polymorphismus signifikant beeinflusst wird. Ebenfalls wird ein signifikanter Effekt des SSRI auf Craving, Befindlichkeit und Intoxikation vermutet. Die Messungen von Verhalten und ACTH Spiegel fanden jeweils zu 2 Zeitpunkten vor und bis zu 6 Zeitpunkten nach der Gabe von Citalopram (CIT) oder Placebo statt. Eingeschlossen wurden 11 männliche Patienten mit der DSM-IV- und ICD-10- Diagnose einer Alkoholabhängigkeit (Durchschnittsalter 36,5 ± 7,7 Jahre), abgeschlossenem Entzug und ohne aktuelle psychopharmakologische Behandlung, psychiatrische oder somatische Komorbidität sowie 12 geschlechts- sowie altersparallelisierte gesunde Kontrollpersonen (Alter: 32,5 ± 6,4 Jahre). Die Patienten wiesen eine durchschnittliche Dauer der Alkoholabhängigkeit von 8.9 ± 3.4 Jahren auf und konsumierten durchschnittlich 326,4 ± 220,8 g/Tag Alkohol in der Woche vor der Entzugsbehandlung. Die durchschnittliche Dosis von Citalopram betrug bei den Patienten 31,96 ± 4,45 mg und den Kontrollen 34,22 ± 7,65mg. Als erstes Ergebnis konnte festgestellt werden, dass Patienten und Kontrollpersonen eine nahezu gleich Anzahl an Fehlern im CPT machten. Allerdings war die Leistung bei beiden Gruppen unter CIT nach 180 Minuten signifikant gegenüber Placebo verbessert. Diese Veränderung war bei Alkoholabhängigen signifikant deutlicher. Somit konnte die erste Hypothese teilweise bestätigt werden. Während sich die endokrine Responsibilität von ACTH unter Placebobedingungen bei Alkoholabhängigen niedriger als bei Kontrollen zeigte, war sie bei beiden Gruppen unter CIT signifikant größer als unter Placebo (bis 90 minuten nach Gabe, p < 0.01). Allerdings konnte kein signifikante Unterschied zwischen Alkoholkranken und Kontrollen für die ACTH Spiegel unter CIT gefunden werden. Genetische Varianten des 5-HTT wiesen keinen signifikanten Zusammenhang mit ACTH Spiegeln unter CIT oder Placebo auf. Die Gruppe der Alkoholabhängigen wies aber unter CIT im Vergleich zu Placebo nicht signifikant mehr Craving auf. Demgegenüber berichteten die Patienten und die Kontrollen unter CIT mehr über Angst (für beide Gruppen, p< 0.05) im Vergleich zu Placebo. Abschließend berichteten die Kontrollpersonen unter Verum über mehr subjektive Zeichen einer alkoholartigen Intoxikation als die Alkoholkranken (p < 0.05). Somit konnte in dieser placebokontrollierten und doppelblinden Studie die Hypothese bestätigt werden, dass der SSRI CIT einen eher günstigen Einfluss auf impulsives Verhalten hat. Dies ergibt möglicherweise Hinweise auf den sinnvollen therapeutischen Einsatz dieser Gruppe von Antidepressiva bei Alkoholabhängigen. Demgegenüber konnten kein Einfluß auf Craving bei der Patientengruppe gefunden werden. Ebenfalls konnte die Hypothese des Zusammenhanges von genetischen Varianten des Serotonintransporters, der auch Wirkort von CIT ist, mit der endokrinen Responsibilität (ACTH) nicht bestätigt werden. Limitation der Studie ist sicherlich die relativ kleine Fallzahl (11 Patienten und 12 Kontrollpersonen).