Podcasts about Elucidation

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Best podcasts about Elucidation

Latest podcast episodes about Elucidation

Glitch Bottle Podcast
A Formula for Calling Seasonal Spirits | Glitch Bottle

Glitch Bottle Podcast

Play Episode Listen Later Oct 2, 2024 22:27


Before any magician summons a spirit listed in a grimoire it's very important to understand ritual timing. Let's explore how spirits of the hour, day and season all should be invoked before the aforementioned target beings, whether celestial, terrestrial, sublunar, airy, elemental, gnomish or of the more infernal variety. Thank you to my Glitch Bottle Patreon supporters for making posts like this possible! ⇓ ⇓ ⇓► ✅Techniques of Solomonic Magic '- https://www.amazon.com/Techniques-Solomonic-Magic-Stephen-Skinner/dp/0738748064/ ► ✅Elucidation of Necromancy (Joseph H. Peterson) - https://www.amazon.com/Elucidation-Necromancy-Lucidarium-Nigromantice-attributed/dp/0892541997/ ► ✅EsotericArchives.com - https://www.esotericarchives.com/solomon/heptamer.htm ✦

No-Problem Parenting™ How to Become the Confident Leader Your Kids Crave You to Be, More Respect, Better Relationship, Get
EP 277 What's the Parents Role in Raising Avid Learners? with authors Dr. Wallace Panlilio II and Dr. Artyom Zinchenko

No-Problem Parenting™ How to Become the Confident Leader Your Kids Crave You to Be, More Respect, Better Relationship, Get

Play Episode Listen Later Jun 18, 2024 32:33 Transcription Available


Welcome Back No-Problem Parents! Are you struggling to maintain your confidence as a parent while juggling school challenges? Our guest experts, Dr. Ardium and Dr. Wallace, introduce their groundbreaking book, "Wisest Learners," designed to transform your approach to your child's academic success. In this episode, we learn the three-step Parental Engagement Cycle (PEC)—modeling, Elucidation, and Feedback—and discuss the power of words and effective strategies to motivate your child from within. Whether you're dealing with toddler tantrums or teenage eye rolls, this episode is packed with invaluable advice to help you become the confident leader your kids crave.    Learn More about Wallace by clicking the links below: Our social media links: Facebook: http://smpl.ro/WisestLearnersFacebook Instagram: http://smpl.ro/WisestLearnersInstagram Tiktok: http://smpl.ro/WisestLearnersTiktok LinkedIn: http://smpl.ro/WisestLearnersLinkedIn Our website and our contact email: Website: http://smpl.ro/WisestLearnersWebsite Info: http://smpl.ro/WisestlearnersInfo   Thank you for tuning in to the No Problem Parenting podcast - Please take a minute to share the podcast, comment or leave a review.   FREE PARENTING RESOURCES: 60 Ways to Respond to Your Kids without Losing Your Cool Make it Right Technique PDF Everyday Essentials eBook   Better Sleep: Decrease Stress with the 7-Day free trial of NuCalm Enter Code: NOPROBLEM for 15% off all products.   Become the Confident Leader Your Kids Crave you to be! Become a No-Problem Parent Book Your 90-Minute Strategy Session Put your oxygen mask on first: Find More Resources Here   FB - IG - LinkedIn - YouTube - Twitter - Threads   Check out our Books! No-Problem Parenting; Raising Your Kiddos with More Confidence and Less Fear No Problem Parenting; Resources and Stories that Create Confidence and Connection   Hugs and High Fives, You Got This!   Jaci Finneman

The Mysteries Of Derlin County
The Elucidation Of Dendellion Arizona

The Mysteries Of Derlin County

Play Episode Listen Later May 25, 2024 24:27


Randy decides to move to Dendellion Arizona and chat with some of the most hardworking thoughtful people in the world. But, someone keeps calling his phone thinking he's someone else. Whom he definitely is NOT!

Future of Education Podcast: Parental guide to cultivating your kids’ academics, life skill development, & emotional growth

Dr. Wallace Panlilio II, Educator and Author of "Wisest Learners", delves into the power of elucidation for kids. As parents and educators, sometimes those endless "whys" from curious kids can leave us feeling exhausted. However, by learning methods to optimize our time and energy, we can learn to answer children's questions in ways that encourage curiosity and the pursuit of knowledge. Today, Dr. Panlilio II discusses the concept of elucidation.Connect With: Dr. Wallace Panlilio: Website // LinkedIn 2Hr Learning: Website // LinkedInI Hear Everything: IHearEverything.com // LinkedIn

BeSimply
BeSimply...On Magnificence {Random Rab}

BeSimply

Play Episode Listen Later Mar 13, 2024 58:57


Join Random Rab and Suzanne Toro as they take a deep dive into his new music collaborations, AI, Nature, creation, freedom, aliens, imagination and his inspiring evolution.Random Rab About Random Rab http://randomrab.netVinyl Order: https://www.diggersfactory.com/vinyl/...Tour: https://randomrab.com/#tourMay 11th with Android Jones https://www.bandsintown.com/e/1052733...About:Emerging from his own distinct corner of the West Coast electronic music scene, Random Rab offers a powerful and unique contribution to sonic exploration. Often referred to as “The Master of Emotion” his music is patently beautiful and melodic. With diverse influences ranging from trip-hop, classical and Arabic to bass driven compositions, his songs are considered anthemic and timeless. As a multi-instrumentalist and singer, his tracks are organic, uplifting and stand on their own as a distinct genre. Listeners of all types of music can find something they can relate to in his sound.There is no doubt that Rab understands a multitude of musical styles. He has been the front man of a heavy metal band, toured as a classical trumpet player, played bass in a country music band, was a scratch DJ for a jazz fusion project, was the singer for a rock band in Mexico and has collaborated with countless musicians of all styles. From acoustic performances in the Himalayas to rocking packed clubs in New York, Random Rab has found a way to connect with people of all kinds. With a dedicated fanbase born from the San Francisco underground, Random Rab has become a Burning Man legend known for his sunrise sets that have now become one of his most sought after performances. His current popularity can often be traced to his breakout album, The Elucidation of Sorrow.. This album firmly established him as a recognizable force in the electronic music scene. His latest and 4th album aRose, catapulted him into the state of momentum that is now taking hold internationally.Sometimes performing solo and at other times featuring collaborative musicians, the live experience is focused on a high quality translation of sound that is simultaneously sexy and psychedelic.

Aging-US
IL-17 Promotes IL-18 Production in Osteoarthritis Synovial Fibroblasts Via…

Aging-US

Play Episode Listen Later Feb 13, 2024 4:19


BUFFALO, NY- February 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.” The concept of osteoarthritis (OA) as a low-grade inflammatory joint disorder has been widely accepted. Many inflammatory mediators are implicated in the pathogenesis of OA. Interleukin (IL)-18 is a pleiotropic cytokine with versatile cellular functions that are pathogenetically important in immune responses, as well as autoimmune, inflammatory, and infectious diseases. IL-17, a proinflammatory cytokine mainly secreted by Th17 cells, is upregulated in OA patients. However, the role of IL-17 in OA progression is unclear. In this new study, researchers Kun-Tsan Lee, Chih-Yang Lin, Shan-Chi Liu, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yuan-Hsin Tsai, Chia-Chia Chao, Po-Chun Chen, and Chih-Hsin Tang from National Chung-Hsing University, Taichung Veterans General Hospital, Shin-Kong Wu Ho-Su Memorial Hospital, Mackay Medical College, China Medical University, Show-Chwan Memorial Hospital, Fu-Jen Catholic University, National Taiwan Normal University, Asia University, and China Medical University Hsinchu Hospital used synovial tissues collected from healthy donors and OA patients to detect the expression level of IL-18 by immunohistochemistry stain. “Elucidation of the molecular mechanisms and main factors involved in OA pathogenesis may help with the development of novel therapeutic targets that relieve OA pain or prevent the disease from progressing.” The OA synovial fibroblasts (OASFs) were incubated with recombinant IL-17 and subjected to Western blot, qPCR, and ELISA to examine IL-18 expression level. The chemical inhibitors and siRNAs which targeted signal pathways were used to investigate signal pathways involved in IL-17-induced IL-18 expression. The microRNAs which participated IL-18 expression were surveyed with online databases miRWalk and miRDB, followed by validation with qPCR. This study revealed significantly higher levels of IL-18 expression in synovial tissue from OA patients compared with healthy controls, as well as increased IL-18 expression in OASFs from rats with severe OA. In vitro findings indicated that IL-17 dose-dependently promoted IL-18 production in OASFs. Molecular investigations revealed that the MEK/ERK/miR-4492 axis stimulated IL-18 production when OASFs were treated with IL-17. “This study provides novel insights into the role of IL-17 in the pathogenesis of OA, which may help to inform OA treatment in the future.” DOI - https://doi.org/10.18632/aging.205462 Corresponding authors - Po-Chun Chen - pcchen@ntnu.edu.tw, and Chih-Hsin Tang - chtang@mail.cmu.edu.tw Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

The Apothecary Podcast With Lori Green
The Grail Series: Elucidation: Mystery, Hospitality, Justice

The Apothecary Podcast With Lori Green

Play Episode Listen Later Oct 17, 2023 92:35


Hi Friends, Join me today for the second episode of The Grail Series. Today we explore the anonymous Old French poem from the 13th century called The Elucidation. This cryptic prologue to the wider grails myths and legends is anything but clear! Nevertheless, our depth-psychological reading of the text offers an additional, unique definition of the wasteland, as well as the feminine origins of this collective epic. In particular, we are able to discern wisdom from three guiding principles: Mystery, hospitality, and justice. Given the tragic eruption of war in the Middle East, and the ongoing suffering globally, this is a powerful moment to integrate the ways in which we can offer the balm of justice to ourselves and others. Musical selection: The Great Unknown by Hampus Naeselius --- Support this podcast: https://podcasters.spotify.com/pod/show/lori-green2/support

The Raider and the Saint
Episode #170 "Elucidation"

The Raider and the Saint

Play Episode Listen Later Aug 19, 2023 69:50


On this Podcast Steven talks about UPSers Pension contribution & the rumors floated around on social media on how the West & its elected officials bowed down to IBT President Sean O'Brien & sold Union members out. Marc Davison; Teamsters VP on the West was recently on the Podcast "Off The Clock Shop Talk". Marc explains how the pensions contributions work across the Country & sets the record straight on false claims. Audio from the Interview granted permission for use for educational purposes.

Glitch Bottle Podcast
Deep Dive: Planetary Conjurations of the Day (Patreon Request)

Glitch Bottle Podcast

Play Episode Listen Later Aug 6, 2023 44:03


Podcast supporters on Patreon voted to go deep into the Heptameron Conjurations for each day of the week. Who are the powerful “Overseers” in each conjuration? We cover history, practical tips, and Solomonic magicians Aaron Leitch, Frater Ashen Chassan and Adley Nichols also stop by to also share their conjuration wisdom! Cheers and thanks to every podcast patron! ⇓ ⇓ ⇓ ►Joseph H. Peterson's Esoteric Archives - http://www.esotericarchives.com/solomon/heptamer.htm ► Get your copy of Joseph H. Peterson's Elucidation of Necromancy - https://www.amazon.com/Elucidation-Necromancy-Lucidarium-Nigromantice-attributed/dp/0892541997 ►Check out Foolish Fish's (excellent!) Planetary Hours video - https://www.youtube.com/watch?v=RxvaEtG0-qY ____Support Aaron Leitch____✅►Doc Solomon's Occult Curios Shop: http://docsolomons.com/wp/ ✅►Support Aaron and Carrie on Patreon: https://www.patreon.com/aaronleitch✅► Get your copy of Aaron Leitch's “Secrets of the Magickal Grimoires” - https://www.amazon.com/Secrets-Magickal-Grimoires-Classical-Deciphered/dp/0738703036 ____Support Frater Ashen Chassan____✅►Check out Frater Chassan's Magical Shop: https://www.facebook.com/Frater-Ashen-Chassans-Magical-Implements-2183349675258729/✅►Sign up for Frater Chassan's Online Master Class for the ‘Lemegeton's Goetia', ‘Drawing Spirits into Crystals' or the ‘Almadel', by contacting him on Facebook to sign up or pay directly via PayPal to BryanAshen@yahoo.com____Support Adley Nichols____✅►Check out Adley's Magical Shop - https://antiquityapothecary.com/ ✅►Adley's Western Magic Facebook Group - https://www.facebook.com/groups/heptameron ✦

PaperPlayer biorxiv cell biology
miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activity

PaperPlayer biorxiv cell biology

Play Episode Listen Later Jul 10, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.10.548366v1?rss=1 Authors: Hayman, D. J., Lin, H., Prior, A., Charlesworth, G., Johnson de Sousa Brito, F. M., Hao, Y., Patel, K., Soul, J., Clark, I. M., Pirog, K. A., Barter, M. J., van 't Hof, R. J., Young, D. A. Abstract: microRNAs (miRNAs) are non-coding RNAs which modulate the expression of other RNA molecules. One miRNA can target many transcripts, allowing each miRNA to play key roles in many biological pathways. miR-324 is a miRNA previously implicated in bone and cartilage maintenance, defects of which result in common age-related diseases, such as osteoporosis or osteoarthritis (OA). In global miR-324-null mice cartilage damage was increased in both surgically and ageing-induced OA, despite minimal changes to the cartilage transcriptome, with few predicted miR-324 targets dysregulated. However, micro-computed tomography and histology demonstrated that global miR-324-null the mice had an increase in bone mineral density, trabecular thickness and cortical thickness, with many parameters increasing with age. The bone marrow of miR-324-null mice also had reduced lipid content while and in vivo TRAP staining revealed a decrease in osteoclasts, with histomorphometry demonstrating an increased rate of bone formation in miR-324-null mice. Ex vivo assays revealed that the high bone mass phenotype of the miR-324-null mice resulted from increased osteoblast activity and decreased osteoclastogenesis. RNA-seq and qRT-PCR followed by miR-324 target prediction and validation in osteoblasts, osteoclasts and bone marrow macrophages identified the osteoclast fusion regulator Pin1 as a miR-324 target in the osteoclast lineage and the master osteogenic regulator Runx2 as a target of miR-324-5p in osteoblasts, the in vitro overexpression of which recapitulated the increased osteogenesis and decreased adipogenesis phenotype observed in vivo. These data point to important roles of miR-324 in skeletal biology with altered bone homeostasis in miR-324-null mice potentially causal for the increased cartilage damage observed during OA and ageing. Elucidation of pathways regulated by miR-324 offer promise for the treatment of bone diseases such as osteoporosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

TYC
We 6/14 - Ooops It's Wednesday | Apple's Branding Lesson | Doritos And Papa John's Make A Baby

TYC

Play Episode Listen Later Jun 14, 2023 18:18


In this episode of Ad Nerds Podcast, aired on WEDNESDAY, June 14, 2023, (not Tuesday) host 'Spanky' Moskowitz delves into the essence of Apple's brand strategy, the exciting collaboration between Papa John's and Doritos aimed at the Gen Z market, and the AI-driven billboard rivalry between fast food giants McDonald's and Burger King. Spanky emphasizes how Apple's innovation, user experience, strong ecosystem, and ability to adapt have contributed to its immense success. He also highlights the effectiveness of strategic partnerships in attracting specific market segments, using the Papa John's-Doritos collaboration as an example. Lastly, the podcast discusses the intriguing use of AI in advertising as illustrated by the playful billboard face-off between McDonald's and Burger King. Key Moments: How Apple maintains consumer trust while continuously innovating (1:35) Discussion on how to emulate Apple's business model in your business (3:51) Elucidation on Apple's strong ecosystem and its importance (6:23) The importance of the long game in brand-building, as it is a marathon, not a sprint (8:20) Analysis of Papa John's and Doritos' high-stakes game of strategy, tapping into the Gen Z market (10:06) Suggestions on how small businesses can implement aspects of the Papa John's and Doritos campaigns without breaking the bank (12:31) Coverage of the burger battle between McDonald's and Burger King (14:51) Breakdown of dueling billboards and a battle of wits with a chatbot (16:17) --- Send in a voice message: https://podcasters.spotify.com/pod/show/adnerds/message

The Project Gutenberg Open Audiobook Collection
An Examination into and an Elucidation of the Grea

The Project Gutenberg Open Audiobook Collection

Play Episode Listen Later Apr 4, 2023 373:08


An Examination into and an Elucidation of the Great Principle of the Mediation and Atonement of Our Lord and Savior Jesus Christ

Glitch Bottle Podcast
Deep Dive: (Mis) Pronouncing Nomina Magica? Scholar updates!

Glitch Bottle Podcast

Play Episode Listen Later Mar 14, 2023 38:05


What is one of the * actual * words on the Triangle of Arte and Ring of Solomon in the Lemegeton's Goetia? Do you call yourself a “steward” or “administrator” in Greek when conjuring spirits? Let's go deep on the history and pronunciation on four ‘nomina magica' or magical words used in famous grimoires in the Goetia, the Heptameron and more! ⇓ ⇓ ⇓ ► EsotericArchives.com - http://www.esotericarchives.com/index.html ► Get your copy of Joseph H. Peterson's Elucidation of Necromancy - https://www.amazon.com/Elucidation-Necromancy-Lucidarium-Nigromantice-attributed/dp/0892541997 ► Get your copy of Rabbi Cohen's ‘Magnus Liber Sigillorum' book - https://www.amazon.com/Magnus-Liber-Sigillorum-abridged-Behold/dp/B0B3737F7Z/ ► Get your copy of Ioannis Marathakis' ‘Magical Treatise of Solomon' book - https://www.amazon.com/Magical-Treatise-Solomon-Hygromanteia-Sourceworks/dp/0993204279/ ► Academic article: “The Function and Identity of the Steward” - https://digitalcommons.aaru.edu.jo/cgi/viewcontent.cgi?article=1090&context=jguaa&fbclid=IwAR1GLWJBBj3oH5a1XhbA75NrEet_JjcTZnDyjSaq8-lZ6Tht977J9AN5L0w ► Get your copy of The Goetia of Dr. Rudd by Dr. Stephen Skinner and David Rankine - https://www.amazon.com/Goetia-Dr-Rudd-Sourceworks-Ceremonial/dp/0954763920 ✦

PaperPlayer biorxiv neuroscience
Elucidation of Amyloid-Beta's Gambit in Oligomerisation:Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, low molecular weight Aβ oligomers that impair synaptic plasticity.

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Dec 5, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.04.519021v1?rss=1 Authors: Gil, B., Rose, J., Demurtas, D., Mancini, G.-F., Sordet-Dessimoz, J., Sorrentino, V., Rudinskiy, N., Frosh, M. P., Hyman, B. T., Moniatte, M., Spires-Jones, T. L., Herron, C. E., Schmid, A. W. Abstract: In Alzheimer's disease (AD), Amyloid-beta (A{beta}) oligomers are considered an appealing therapeutic- and diagnostic target. However, to date, the molecular mechanisms associated with the pathological accumulation or structure of A{beta} oligomers remains an enigma to the scientific community. Here we demonstrate the strong seeding properties of unique A{beta} fragment signatures and show that the truncated A{beta}peptides of residues A{beta}1-23, A{beta}1-24 and A{beta}1-25, rapidly seed to form small, SDS-PAGE stable assemblies of ~5kDa to ~14kDa molecular mass range. Mass spectrometry analysis of SDS-PAGE fractionated and gel extracted oligomers revealed that the truncated A{beta} isoforms of residues 1-23 to 1-25 form stable entities with low molecular weight (LMW) oligomers, which strongly resemble the regularly reported A{beta} entities of putative dimeric or trimeric assemblies found in human post-mortem AD and Tg mouse brain extracts. Furthermore, electrophysiological recordings in the mouse hippocampus indicate that LMW A{beta} assemblies formed by fragments A{beta}1-23 to A{beta}1-25 significantly impair long-term-potentiation (LTP) in the absence of full-length A{beta}1-42. Extensive antibody screening highlights the important observation, that the LMW A{beta} assemblies formed by these truncated A{beta} peptides escape immuno-detection using conventional, conformation specific antibodies but, more importantly, the clinical antibody aducanumab. Our novel findings suggest that there are new A{beta} target loopholes which can be exploited for the development of therapeutic antibodies with binding properties against stable target hotspots present in A{beta} oligomers. We provide here a first example of a new class of monoclonal antibody with unique binding properties against LMW A{beta} oligomers, in the absence of binding to large fibrillar A{beta} assemblies, or dense amyloid plaques. Our research supports a novel, unparalleled approach for targeting early, pathological A{beta} species during the insidious phase of AD and prior to the appearance of large oligomeric or protofibrilar assemblies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rabbi Daniel Glatstein Podcast
Noach : The Mystery Of "YISKAH" - An Original Elucidation

Rabbi Daniel Glatstein Podcast

Play Episode Listen Later Oct 27, 2022 5:46


NIGHT-LIGHT RADIO
The Lost Book of the Grail with Caitlin and John Matthews

NIGHT-LIGHT RADIO

Play Episode Listen Later Sep 29, 2022 59:00


Unveiling the long-forgotten prequel to the Grail quest stories, Caitlín and John Matthews examine The Elucidation of the Grail, a forgotten 13th-century French text, and show how it offers the key to understanding the sevenfold path of the Grail and the deeper stories beneath the Christian Grail narrative. Beginning with a new translation of The Elucidation by foremost esotericist Gareth Knight and Caitlín Matthews, the authors provide a complete commentary on the poem, revealing a startling alternative cause of the Wasteland and the Grail quest, one which has a profound resonance with our own times. They examine the forgotten story of the Faery Wars and explain the Faery Accord, an agreement that once existed between humans and the Faery and upon which the spiritual and physical health of the land depends. The offering of the Grail and its regenerative powers by the Maidens of the Wells--Faery women--was part of this Accord. King Amangons and his men violated the Accord, through their abuse of the Well Maidens and other evil actions, causing the wasting of the land. The Knights of King Arthur seek to avenge the Well Maidens and rebirth the Grail to restore access to the lost paradisiacal “Courts of Joy” held in ancestral memory. On their quest, they encounter the Rich Company whose greed keeps the Knights occupied in long wars of attrition, yet their quest to restore the generous hospitality of the Wells--the true Grail, the Faery Grail--continues. In addition to the Faery Accord and Knights' quest, the authors examine the Seven Guardians of the Stories, the Rich Fisher, the Courts of Joy and paradise lost, and the otherworldly Land of Women. They show how this lost book of the Grail reveals themes familiar to the modern world and offers hope of healing the rift between the worlds of Faery and human as well as restoration of our natural belonging to the land.

NIGHT-LIGHT RADIO
The Lost Book of the Grail with Caitlin and John Matthews

NIGHT-LIGHT RADIO

Play Episode Listen Later Sep 29, 2022 58:41


Unveiling the long-forgotten prequel to the Grail quest stories, Caitlín and John Matthews examine The Elucidation of the Grail, a forgotten 13th-century French text, and show how it offers the key to understanding the sevenfold path of the Grail and the deeper stories beneath the Christian Grail narrative. Beginning with a new translation of The Elucidation by foremost esotericist Gareth Knight and Caitlín Matthews, the authors provide a complete commentary on the poem, revealing a startling alternative cause of the Wasteland and the Grail quest, one which has a profound resonance with our own times. They examine the forgotten story of the Faery Wars and explain the Faery Accord, an agreement that once existed between humans and the Faery and upon which the spiritual and physical health of the land depends. The offering of the Grail and its regenerative powers by the Maidens of the Wells--Faery women--was part of this Accord. King Amangons and his men violated the Accord, through their abuse of the Well Maidens and other evil actions, causing the wasting of the land. The Knights of King Arthur seek to avenge the Well Maidens and rebirth the Grail to restore access to the lost paradisiacal “Courts of Joy” held in ancestral memory. On their quest, they encounter the Rich Company whose greed keeps the Knights occupied in long wars of attrition, yet their quest to restore the generous hospitality of the Wells--the true Grail, the Faery Grail--continues. In addition to the Faery Accord and Knights' quest, the authors examine the Seven Guardians of the Stories, the Rich Fisher, the Courts of Joy and paradise lost, and the otherworldly Land of Women. They show how this lost book of the Grail reveals themes familiar to the modern world and offers hope of healing the rift between the worlds of Faery and human as well as restoration of our natural belonging to the land.

Night-Light Radio
The Lost Book of the Grail with Caitlin and John Matthews

Night-Light Radio

Play Episode Listen Later Sep 29, 2022 58:41


Unveiling the long-forgotten prequel to the Grail quest stories, Caitlín and John Matthews examine The Elucidation of the Grail, a forgotten 13th-century French text, and show how it offers the key to understanding the sevenfold path of the Grail and the deeper stories beneath the Christian Grail narrative.Beginning with a new translation of The Elucidation by foremost esotericist Gareth Knight and Caitlín Matthews, the authors provide a complete commentary on the poem, revealing a startling alternative cause of the Wasteland and the Grail quest, one which has a profound resonance with our own times. They examine the forgotten story of the Faery Wars and explain the Faery Accord, an agreement that once existed between humans and the Faery and upon which the spiritual and physical health of the land depends. The offering of the Grail and its regenerative powers by the Maidens of the Wells--Faery women--was part of this Accord. King Amangons and his men violated the Accord, through their abuse of the Well Maidens and other evil actions, causing the wasting of the land. The Knights of King Arthur seek to avenge the Well Maidens and rebirth the Grail to restore access to the lost paradisiacal “Courts of Joy” held in ancestral memory. On their quest, they encounter the Rich Company whose greed keeps the Knights occupied in long wars of attrition, yet their quest to restore the generous hospitality of the Wells--the true Grail, the Faery Grail--continues.In addition to the Faery Accord and Knights' quest, the authors examine the Seven Guardians of the Stories, the Rich Fisher, the Courts of Joy and paradise lost, and the otherworldly Land of Women. They show how this lost book of the Grail reveals themes familiar to the modern world and offers hope of healing the rift between the worlds of Faery and human as well as restoration of our natural belonging to the land.

KnotWork Storytelling
Bright And Obscure: Stories of the Irish Goddess Áine with Jen Murphy | S. 2 Ep. 5

KnotWork Storytelling

Play Episode Listen Later Aug 24, 2022 47:54


Our Story A Irish sovereignty goddess whose origins lie with the mythical Tuatha Dé Danann, Áine is also a sun deity, a bean sidhe (woman of the Sí), and fairy queen. Our guest Jen Murphy comes to KnotWork with a collection of Áine tales.  In a story from the mythological period, Áine has an ill-fated meeting with the unjust king Aillil Ólomm, who strips the land bare and threatens the goddess. Later, Áine is also found in a 14th century tale of Gerald, Earl of Desmond, also known as “The Wizard Earl.” Finally, a story collected in 1938 by the Irish Folklore Commission about a wise woman named Áine with two daughters who refuse to follow their mother's marital advice, each with disastrous results. Our Guest Jen Murphy is the creator of Celtic Embodiment, a cutting-edge modality that fuses the ancient wisdom of Celtic Mythology with the emerging field of Feminine Embodiment Coaching to transform modern life for women. Jen is a certified Feminine Embodiment Coach and holds a degree in Medieval Irish & Celtic Studies and an M.A. in the Anthropology of Development. Coming from a lineage of storytellers and wisdom keepers on her maternal line, Jen is fascinated by the natural coalescence between our ancestral myths and our bodies as a potent brew to reclaim our sovereign power.  Find Jen at https://www.celticembodiment.com/ (www.celticembodiment.com/) and on Instagram: @celticembodiment Our Conversation The ancient Celtic Sovereignty myth: the divine marriage (the banais ríghi). When the Sovereignty goddess unites with the king, she expects fir flaithemon, the prince's truth. A worthy ruler needs to be just, truthful, and discerning. Parallels to Sumerian tales of Inanna and her partners. The importance of reciprocity - between people and land, between sovereignty goddess and king The ways that religion and politics collude together and exploit the land Connections to Arthurian Grail legend and “The Elucidation,”a tale that describes the rape of the Well Maidens that leads to the closing of the wells and creation of the Wasteland. Hospitality as a key aspect of mythology and culture Ireland as a “goddess obsessed” island. And yet, with all of the divine feminine magic, all of the Mother Goddess worship, it was not a Utopia for women. There were ways in which the coming of the church offered a haven for women, and monasteries became places of learning. Jen's personal story of what it meant to see all part of herself, integrate the energy of midsummer, the deepest energy of the grandmothers, a death of a part of the self, and  rebirth and integration Our Music Music at the start of the show is by Beth Sweeney and Billy Hardy, a Celtic Fiddle and multi-instrumental duo based on Cape Cod, Massachusetts. The traditional Irish reel we play at the start of the show is called "The College Groves." https://www.knotworkstorytelling.com/episode/billyandbeth.com (billyandbeth.com) Join Us in the Heroine's KnotThe Heroines' Knot is an online community for creative creatures on the quest for self-expression & collective renewal. https://my.captivate.fm/www.marisagoudy.com/heroines-knot (Learn more and join us.) 1:1 Coaching Opportunities Marisa offers 1:1 coaching for Personal and Professional growth with her https://www.marisagoudy.com/healing-for-heroines (Healing for Heroines) packages. She also offers https://www.marisagoudy.com/story-weaver-book-coaching (Story Weaver Book Coaching )for memoirists, thought leaders, and creative entrepreneurs at the beginning of their writing journey. Find more of Marisa's writing and get a copy of her book, The Sovereignty Knot https://www.knotworkstorytelling.com/episode/www.marisagoudy.com (www.marisagoudy.com) Follow the show on https://www.instagram.com/knotworkpodcast/ (Instagram), https://www.facebook.com/knotworkstorytelling (Facebook), and jhttps://www.facebook.com/groups/4429930243750952 (oin our...

Nat Wonderful
Latin Club: XIX. Elucidation

Nat Wonderful

Play Episode Listen Later Jun 22, 2022 65:34


A brick flies through the window of a University Professor's home. Soon after, 3 intruders enter the house in search of their friend. Screams are heard from the garage while the 3 men sneak through the house to reach their kidnapped partner.

Nat Wonderful
Latin Club: XIX. Elucidation

Nat Wonderful

Play Episode Listen Later Jun 22, 2022 65:33


A brick flies through the window of a University Professor's home. Soon after, 3 intruders enter the house in search of their friend. Screams are heard from the garage while the 3 men sneak through the house to reach their kidnapped partner.

BeSimply
BeSimply...Random Rab. Ilya Goldberg {Dos}

BeSimply

Play Episode Listen Later Jun 14, 2022 48:38


Join Random Rab and Ilya Goldberg (aka Lapa) with Suzanne Toro as they share some of the creative seeds that are feeding their new music and upcoming album. Their new collaboration is an exciting compilation of both their talents and past history merging into the present moment.About Random Rab Emerging from his own distinct corner of the West Coast electronic music scene, Random Rab offers a powerful and unique contribution to sonic exploration. Often referred to as “The Master of Emotion” his music is patently beautiful and melodic. With diverse influences ranging from trip-hop, classical and Arabic to bass driven compositions, his songs are considered anthemic and timeless. As a multi-instrumentalist and singer, his tracks are organic, uplifting and stand on their own as a distinct genre. Listeners of all types of music can find something they can relate to in his sound.There is no doubt that Rab understands a multitude of musical styles. He has been the front man of a heavy metal band, toured as a classical trumpet player, played bass in a country music band, was a scratch DJ for a jazz fusion project, was the singer for a rock band in Mexico and has collaborated with countless musicians of all styles. From acoustic performances in the Himalayas to rocking packed clubs in New York, Random Rab has found a way to connect with people of all kinds. With a dedicated fanbase born from the San Francisco underground, Random Rab has become a Burning Man legend known for his sunrise sets that have now become one of his most sought after performances. His current popularity can often be traced to his breakout album, The Elucidation of Sorrow.. This album firmly established him as a recognizable force in the electronic music scene. His latest and 4th album aRose, catapulted him into the state of momentum that is now taking hold internationally.Sometimes performing solo and at other times featuring collaborative musicians, the live experience is focused on a high quality translation of sound that is simultaneously sexy and psychedelic.About Ilya Goldberg (aka Lapa,)  and Emancipator Lapa is a west coast producer, performer and multi-instrumentalist, and is currently based out of Portland, Oregon.Being originally from Russia and having studied classical violin for most of his life, Lapa's music bridges styles, rhythms and melodies from around the world in a tasteful and eloquent way. His beats draw inspiration anywhere from classic trip-hop to groovy house, supported by a sonic blanket of juicy bass and heart-felt violin melodies.

The Analytical Wavelength
The Case for CASE - Computer-Assisted Structure Elucidation

The Analytical Wavelength

Play Episode Listen Later Apr 5, 2022 33:10


What is this chemical? This is a problem for scientists since the discovery of the elements. For the modern chemist, software tools can help solve this problem. Computer assisted structure elucidation (CASE) is one of the most powerful and versatile tools available when determining chemical structures.Join Charis and Jesse as they discuss the past, present, and future of CASE. How can CASE help your chemistry? Let's find out.Learn more about CASE software: https://www.acdlabs.com/products/com_iden/elucidation/struc_eluc/Hosts:  Jesse HarrisCharis Lam Guests:Dimitris ArgyropoulosJean-Marc Nuzillard Brought to you by ACD/Labs: www.acdlabs.com

Glitch Bottle Podcast
#107 - The Elucidation of Necromancy with Joseph H. Peterson | Glitch Bottle

Glitch Bottle Podcast

Play Episode Listen Later Dec 20, 2021 55:15


How is the well-known Heptameron grimoire based on an earlier text with key elements, known as the Elucidation of Necromancy (Lucidarium artis Nigromantice)? In the first major update to our understanding of the Heptameron in more than 500 years, scholar, author and translator Joseph H. Peterson shares about his translation and contextualization of three “Lucidarium” manuscripts, which he brings together in his new book from Ibis Press entitled “Elucidation of Necromancy”, answers your Patreon listener questions and more! ⇓ ⇓ ⇓ ► ✅ (Red Wheel Weiser) “Elucidation of Necromancy” - https://redwheelweiser.com/detail.html?id=9780892541997 ► ✅ (Amazon) “Elucidation of Necromancy” - https://www.amazon.com/Elucidation-Necromancy-Lucidarium-Nigromantice-attributed/dp/0892541997/ ► ✅Read the full Heptameron text on Joe's amazing site, EsotericArchives - http://www.esotericarchives.com/solomon/heptamer.htm ✦

MAGICk WITHOUT FEARs
#063 Adley Nichols "Elucidation of Necromancy, Heptameron & Enochian"

MAGICk WITHOUT FEARs "Hermetic Podcast" with Frater R∴C∴

Play Episode Listen Later Nov 10, 2021 191:02


Visit: https://www.adleysmagic.comwww.hermeticpodcast.comSupport this podcast at — https://redcircle.com/magick-without-fears-frater-r-c-hermetic-podcast/exclusive-contentAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Monday Morning Minutes
MMM Episode 32: Sep. 7-10 Macro/Market Recap, Eviction Elucidation & Janet's Alarm Bells

Monday Morning Minutes

Play Episode Listen Later Sep 10, 2021 32:22


After reviewing a red week for stocks, gold (almost -2%) and Bitcoin (almost -9%) and a flat week for bonds and commodities, Jeff Mayberry and Samuel Lau size up the impact on housing evictions and rents, as well as the possibility of durable follow-throughs into inflation gauges, after the U.S. Supreme Court's overturning of the Biden administration's eviction moratorium (11:05). With an estimated 750,000 households facing possible eviction and 3½ million households behind on their rent, the ruling stands to have significant economic and social repercussions, but those will take time to emerge. Given listener interest in the in's and out's of U.S. Treasury auctions, Jeff and Same discuss the tone the Sept. 9 Long Bond auction (3:18). The auction brought $24 billion of Uncle Sam's 30-year IOUs to market; the Long Bond “traded through”: nearly 2 basis points below its pre-auction level. That's “a sign,” Jeff notes, “that demand exceeded dealers' expectations.” The co-hosts consider Treasury Secretary Janet Yellen's alarm bells to Congress over the national debt ceiling deadline, and … they roll their eyes (27:21).

Redeemer Presbyterian Church (PCA)
Daniel's Elucidation Of Christ's Eternal Kingdom

Redeemer Presbyterian Church (PCA)

Play Episode Listen Later Aug 1, 2021 32:00


Aim- To Believe and Live As Kingdom Churchmen--Key Phrase-v. 44a- -And in the days of those kings the God of heaven will set up a kingdom that shall never be destroyed . . . - -ESV-

Redeemer Presbyterian Church (PCA)
Daniel's Elucidation Of Christ's Eternal Kingdom

Redeemer Presbyterian Church (PCA)

Play Episode Listen Later Aug 1, 2021 32:00


Aim- To Believe and Live As Kingdom Churchmen--Key Phrase-v. 44a- -And in the days of those kings the God of heaven will set up a kingdom that shall never be destroyed . . . - -ESV-

Redeemer Presbyterian Church (PCA)
Daniel's Elucidation Of Five Kingdoms

Redeemer Presbyterian Church (PCA)

Play Episode Listen Later Jul 31, 2021 38:00


Aim- To Be Faithful Members of the Eternal -Church- Kingdom of Christ--Key Phrase-v. 44a- -And in the days of those kings the God of heaven will set up a kingdom that shall never be destroyed, nor shall the kingdom be left to another people.- -ESV-

In My Expert Opinion
Photolithography of the Heart

In My Expert Opinion

Play Episode Listen Later Apr 27, 2021 42:49


In our last One Hundred Years of Solitude episode, we delve into the development of photography and imagine a beautiful, but made-up, love story between its early inventors! . Resources: Tobisch, V. (2019) “Highly Photosensitive Daguerreotypes and their Reproduction: Physico‐chemical Elucidation of Innovative Processes in Photography Developed around 1840 in Vienna.” Motamedi, J. (2010) “A Brief Guide To Becquerel Daguerreotype.” Music: "Dance Robot ACTIVATE" by Loyalty Freak Music. [All views expressed are our own and do not represent the opinions of any entity with which we are affiliated.]

Curtains on Fire
Episode 3 - A Conundrum, Elucidation, ID, Sorry, John

Curtains on Fire

Play Episode Listen Later Apr 17, 2021 26:48


It's the third episode of "Curtains on Fire," featuring new works from the Rising Curtain Theatre Company. In this episode, we feature four new plays: "A Conundrum" by Lynn Langone, "Elucidation" by Ted Wrigley, "ID" by Alex Bernstein, and "Sorry, John" by Jake Daehler.

USAVFHF
ELUCIDATION: GODISM REVISITED

USAVFHF

Play Episode Listen Later Apr 13, 2021 23:50


Tripping to the roots to understand pfesent confusions, and way out. Family feuds. What to expose vs what to cover up. --- Support this podcast: https://anchor.fm/ayodele-ayetigbo/support

Instrumental Breakthoughs
#35: Random Rab - Instrumental Breakthroughs by Tam Integration

Instrumental Breakthoughs

Play Episode Listen Later Mar 22, 2021 56:37


Psychedelics, Music, and Art go hand in hand. So many of us are moved to express our insights and visions through our creativity. Join Daniel of Tam Integration as he talks to a wide variety of masterful creatives about how their magical flights of fancy have inspired their art. Streaming every monday on the Deadheadland facebook page. The Happeningest Place On Earth! Emerging from his own distinct corner of the West Coast electronic music scene, Random Rab offers a powerful and unique contribution to sonic exploration. Often referred to as “The Master of Emotion” his music is patently beautiful and melodic. With diverse influences ranging from trip-hop, classical and Arabic to bass driven compositions, his songs are considered anthemic and timeless. As a multi-instrumentalist and singer, his tracks are organic, uplifting and stand on their own as a distinct genre. Listeners of all types of music can find something they can relate to in his sound. There is no doubt that Rab understands a multitude of musical styles. He has been the front man of a heavy metal band, toured as a classical trumpet player, played bass in a country music band, was a scratch DJ for a jazz fusion project, was the singer for a rock band in Mexico and has collaborated with countless musicians of all styles. From acoustic performances in the Himalayas to rocking packed clubs in New York, Random Rab has found a way to connect with people of all kinds. With a dedicated fanbase born from the San Francisco underground, Random Rab has become a Burning Man legend known for his sunrise sets that have now become one of his most sought after performances. His current popularity can often be traced to his breakout album, The Elucidation of Sorrow.. This album firmly established him as a recognizable force in the electronic music scene. His latest and 4th album aRose, catapulted him into the state of momentum that is now taking hold internationally. Sometimes performing solo and at other times featuring collaborative musicians, the live experience is focused on a high quality translation of sound that is simultaneously sexy and psychedelic.   If you feel moved, please support the show https://tamintegration.com/donate https://patreon.com/tamintegration

Flipping Pages.
Chapter 20

Flipping Pages.

Play Episode Listen Later Mar 4, 2021 4:55


The Elucidation

Heels In The Courtroom
EP206 - Effective Legal Elucidation/How to Write Better

Heels In The Courtroom

Play Episode Listen Later Nov 11, 2020 40:04


Is your legal writing as persuasive as your argument? Are you getting to the point or wasting time searching a thesaurus? Erica, Liz, Mary and Elizabeth share insights on how to set a communication goal, establish the proper tone, address the appropriate audience and keep your message simple.  You’ll also  learn their most feared typos and uncover common copy and paste pitfalls.

Freedom Prepper Podcast
Paperclips, Buffoons, Corpses and Cameras, Elucidation, and more.

Freedom Prepper Podcast

Play Episode Listen Later Nov 9, 2020 17:19


Want to know when Freedom Roasters Coffee is ready? Sign up here http://freedomprepper.com/FreedomRoastersCoffee If you're looking to gift yourself some cool gear, or want to gift to someone else, BattlBox offers several boxes that won't let you down, check them out: http://freedomprepper.com/battlbox WATCH:Learn to Survive the Bitter Cold and Snow https://www.youtube.com/watch?v=AEvGaaPxubE Follow off of YouTube: https://linktr.ee/freedomprepper Link to each article in today's Post http://freedomprepper.com/prepper-post-news-11-9-2020

PaperPlayer biorxiv biochemistry
Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Nov 8, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.06.371534v1?rss=1 Authors: Ghosh, D., Bansode, S., Joshi, R. S., Kolte, B., Gacche, R. Abstract: The serine protease, elastase exists in various forms and plays diverse roles in the human body. Pharmacological inhibition of elastase has been investigated for its therapeutic role in managing conditions such as diabetes, pneumonia and arthritis. Sivelestat, a synthetic molecule, is the only elastase inhibitor to have been approved by any major drug regulatory authority (PMDA, in this case), but still has failed to attain widespread clinical usage owing to its high price, cumbersome administration and obscure long-term safety profile. In order to find a relatively better-suited alternative, screening was conducted using plant flavonoids, which yielded Baicalein, a molecule that showed robust inhibition against Pancreatic Elastase inhibition (IC50: 3.53 micromolar). Other than having an IC50 almost 1/5th of that of sivelestat, baicalein is also cheaper, safer and easier to administer. While Microscale thermophoresis validated baicalein-elastase interaction, enzyme-kinetic studies, molecular docking and molecular dynamic simulation revealed the mode of inhibition to be non-competitive. Baicalein exhibited binding to a distinct allosteric site on the enzyme. The current study demonstrates the elastase inhibition properties of baicalein in an in-vitro and in-silico environment. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biophysics
Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay

PaperPlayer biorxiv biophysics

Play Episode Listen Later Oct 18, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.18.336891v1?rss=1 Authors: Ueno, H., Kato, M., Minagawa, Y., Hirose, Y., Noji, H. Abstract: Alkaline phosphatase (ALP), a homo-dimeric enzyme has been widely used in various bioassays as disease markers and enzyme probes. Recent advancements of digital bioassay revolutionized ALP-based diagnostic assays as seen in rapid growth of digital ELISA and the emerging multiplex profiling of single-molecule ALP isomers. However, the intrinsic heterogeneity found among ALP molecules hampers the ALP-based quantitative digital bioassays. This study aims quantitative analysis of single-molecule activities of ALP from Escherichia coli and reveals the static heterogeneity in catalytic activity of ALP with two distinct populations: half-active and fully active portions. Digital assays with serial buffer exchange uncovered single-molecule Michaelis-Menten kinetics of ALP; half-active molecules have halved values of the catalytic turnover rate, kcat, and the rate constant of productive binding, kon, of the fully active molecules. These findings suggest that half-active ALP molecules are heterogenic dimers composed of inactive and active monomer units, while fully active ALP molecules comprise two active units. Static heterogeneity was also observed for ALP with other origins: calf intestine or shrimp, showing how the findings can be generalized across species. Cell-free expression of ALP with disulfide bond enhancer and spiked zinc ion resulted in homogenous population of ALP of full activity, revealing that inactive monomer units of ALP are deficient in disulfide bond formation and zinc ion coordination, and also offering the way to prepare homogenous and active populations of ALP for quantitative digital bioassays of ALP. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv bioinformatics
A deep learning framework for elucidating whole-genome chemical interaction space

PaperPlayer biorxiv bioinformatics

Play Episode Listen Later Oct 9, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.08.332346v1?rss=1 Authors: Cai, T., Lim, H., Abbu, K. A., Qiu, Y., Nussinov, R., Xie, L. Abstract: Molecular interaction is the foundation of biological process. Elucidation of genome-wide binding partners of a biomolecule will address many questions in biomedicine. However, ligands of a vast number of proteins remain elusive. Existing methods mostly fail when the protein of interest is dissimilar from those with known functions or structures. We develop a new deep learning framework DISAE that incorporates biological knowledge into self-supervised learning techniques for predicting ligands of novel unannotated proteins on a genome-scale. In the rigorous benchmark studies, DISAE outperforms state-of-the-art methods by a significant margin. The interpretability analysis of DISAE suggests that it learns biologically meaningful information. We further use DISAE to assign ligands to human orphan G-Protein Coupled Receptors (GPCRs) and to cluster the human GPCRome by integrating their phylogenetic and ligand relationships. The promising results of DISAE open an avenue for exploring the chemical landscape of entire sequenced genomes. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv bioinformatics
Virtual Screening and Elucidation of Putative Binding Mode for Small Molecule Antagonist of BCL2 BH4 Domain

PaperPlayer biorxiv bioinformatics

Play Episode Listen Later Jul 30, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.29.226308v1?rss=1 Authors: Joel, I. y., Adigun, T. O., AJIBOLA, A. O., BANKOLE, O. O., OZOJIOFOR, U. O., REMI-ESAN, I. A., SULAIMON, L. A. Abstract: Evading apoptosis is one of the hallmarks of cancer cells, therefore a lot of therapeutic strategies have been developed to induce cell death in these cells. BCL2 family protein governs the intrinsic pathway of cell death. The BCL2 family protein possess both pro and anti-apoptosis members. BCL2 protein, a pioneering member of the anti-apoptosis protein has been implicated in several cancerous cells; with dozens of small-molecule inhibitors developed to inhibit its activity. BCL2 family protein processes BH domains (1-4) for heterodimerization and homodimerization amidst it family members and targeting the BH4 domain is an established new strategy for cancer therapy; however, only BDA366 has been reported so far as a BH4 binding molecule. Using Computer-aided drug discovery techniques (Molecular docking, QM-polarized docking, Induced-fit docking, QM-MM optimization, and QM electronic descriptors) we screened M sample (~ 99,000 compounds) of the SCUBIDOO database to find ligands that interact with the BH4 domain of BCL2 protein with high affinity, we identified 11 putative BH4 specific small molecules with binding affinity ranging from ~ -84kcal/mol to -64kcal/mol with a putative binding hypothesis with BH4 amino acid residues: ASP10, ARG12, GLU13, MET16, LYS17, and HIS20 Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biophysics
Elucidation of cryptic and allosteric pockets within the SARS-CoV-2 protease

PaperPlayer biorxiv biophysics

Play Episode Listen Later Jul 24, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.23.218784v1?rss=1 Authors: Sztain, T., Amaro, R. E., McCammon, J. A. Abstract: The SARS-CoV-2 pandemic has rapidly spread across the globe, posing an urgent health concern. Many quests to computationally identify treatments against the virus rely on in silico small molecule docking to experimentally determined structures of viral proteins. One limit to these approaches is that protein dynamics are often unaccounted for, leading to overlooking transient, druggable conformational states. Using Gaussian accelerated molecular dynamics to enhance sampling of conformational space, we identified cryptic pockets within the SARS-CoV-2 main protease, including some within regions far from the active site and assed their druggability. These pockets can aid in virtual screening efforts to identify a protease inhibitor for the treatment of COVID-19. Copy rights belong to original authors. Visit the link for more info

The Problem Solvers
Ted Tawkward

The Problem Solvers

Play Episode Listen Later Apr 24, 2020 44:16


Oh man shit just got weird.  Wanna know what happens when a really cool dude interviews two drunk weird dudes? Well today's your lucky day!  Buckle up as we take on an interesting thought experiment; can we figure out what makes people awkward?  Spoiler alert, the answer is no. 

The Problem Solvers
We're Unpopular and Opinionated

The Problem Solvers

Play Episode Listen Later Apr 17, 2020 44:10


The quarantine has made us negative in the brain and mouth, so we're airing out our grievances.  We cover some of our unpopular opinions and those of our listeners and followers.  Let me get this out of the way now, we're sorry to the ladies, we're not sexiest.