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Ich traf meinen Mindset-Hero Ben Ouattara. Ohne ihn wäre ich nicht da, wo ich heute bin. Vor einigen Jahren kam ich auf seinen Podcast "Mach es einfach und mach es einfach". Es folgte das persönliche Coaching durch ihn, welches mir und meinem Business einen enormen Schub nach vorne brachte. Und jetzt war es soweit: Ich traf Ben persönlich. Ein kleiner Traum von mir ging in Erfüllung. Natürlich ließen wir uns die Chance nicht nehmen, eine Podcast-Folge zu produzieren: Es geht um meine Entwicklung; Mindset; Insider-Wissen zu Werkzeugen, mit denen ich arbeite und geballten Input vom High-Performance-Coach persönlich. Ich sag: "Achtung, diese Folge hat Power!"
In this episode of The Grazing Grass Podcast, Cal talks with James Coffelt of Ohio Land and Cattle! We discuss low input management of the ranch's Angus cows, as well as, paddlefish and hunting. Show notes available at https://grazinggrass.com/episodes/40
Menschen wiederholen deine Aussage, unterbrechen in der Diskussion oder reden ohne Unterlass: Kommunikation – ob im Job oder Privaten– kann ganz schön fordernd sein. Gleichzeitig ist sie wohl der wichtigste Hebel für einen wertschätzenden Austausch und hält unschätzbares Potenzial, um gemeinsam Großes zu erschaffen. Es ist deshalb auch ganz natürlich, dass wir schwierige Gesprächssituationen eher scheuen. Trotzdem sollten wir die Kraft insbesondere schwieriger Gespräche nicht unterschätzen: Aus einer auf den ersten Blick unangenehmen und anstrengenden Diskussion kann wertvoller Input für die Weiterentwicklung unser Persönlichkeit, einer Organisation oder der Gesellschaft entstehen. Was es dafür braucht? Den Mut, einen Konflikt zu riskieren und die Offenheit, die Perspektive zu wechseln, um bestehende Narrative zu durchbrechen. Hierarchien, Machtdynamiken, aber auch persönliche Erfahrungen und Ängste formen (vermeintlich wahre) Erzählungen darüber, wer wir sind und sein können. Sie beeinflussen meistens unmerklich unser Verhalten und können so sehr einschränkend wirken: „Andere können das doch viel besser“, „Ich war noch nie gut in …“, „Meine Worte kommen eh nicht oben an“, sind typische Denkmuster, die sich zu Narrativen formen und uns davon abhalten, in unsere volle Kraft zu kommen. In Podcastfolge #186 erfährst du, welche Technik du nutzen kannst, um Narrative zu verändern und so mit einer neuen Energie in schwierige Gespräch zu gehen. Denn in jedem Gespräch liegt die Chance zu mehr Verbundenheit und einem respektvollen Miteinander auf Augenhöhe.
I finally took in all the input I could hold and sat back and realized, I'm doing this my way …. it may not be perfect, but it must have my stamp on it, otherwise what's the point right? We always, always have to return to who we are at our core and do what makes sense for you- and that may not make sense to anyone else but you. You. The fabulously unique you.
Jean Henning with the North Dakota Corn Utilization Council says rising fertilizer costs are a top concern for the corn industry. See omnystudio.com/listener for privacy information.
LINKS buymeacoffee.com/changeug The ChangeUnderground Academy No-Dig Gardening Course: https://worldorganicnews.com/changeunderground/ FREE eBook: https://worldorganicnews.com/freeebook/ email: jon@worldorganicnews.com Facebook Page: https://www.facebook.com/groups/1546564598887681 Transcript https://worldorganicnews.com/episode279/ Bubugo Conservation Trust http://www.bubugoconservation.org/ Britain's half-arsed climate summit https://www.politico.eu/article/cop26-uk-britain-boris-johnson-glasgow-climate-summit-london/ No fertiliser and no hay making but still plenty of grass for the cattle https://www.abc.net.au/radio/programs/tas-country-hour/intensive-grazing/13572266 Episode 260. Small Scale Grain Growing https://worldorganicnews.com/episode260/ JADAM is a group of organic farmers https://en.jadam.kr/com/com-1.html Journey to Forever: Small farms http://journeytoforever.org/farm.html
Nucs over double-screen boards, more winter patty love, boxes with wood shavings vs foam board top insulation....the winter testing ground here we come. An extra for patrons--Links to equipment and videos mentioned in this episode: https://www.patreon.com/posts/58906090 Please become a "Friend of the Podcast" on Patreon and join the folks who make the podcasts possible! In addition to huge gratitude, you get: • BONUS podcasts and early access episodes • Access to Patreon blog posts including tips and videos • Special Q&A posts to ask me questions about YOUR bees • Input on the podcast topics • Shout-outs on the show because I appreciate you! If you can support the show with $1 a month or more, please sign up today: https://www.patreon.com/fiveapple -- About Beekeeping at Five Apple Farm: Leigh keeps bees at 3000' in the Blue Ridge Mountains of North Carolina. She cares for around a 'beekeeper's dozen' of hives in a rural, high elevation Appalachian forest climate. Colonies are managed for bee health with active selection for vigor, genetic diversity and disease resistance, but without chemical treatments. The apiary is self-sustaining (not needing to buy/catch replacement bees since 2010) and produces honey and nucs most every year.
A historic drought followed by rising input costs have been extremely stressful for many North Dakota farmers. Ag Commissioner Doug Goehring talks more about the state of current ag economy. See omnystudio.com/listener for privacy information.
Best of the Left - Progressive Politics and Culture, Curated by a Human
Air Date 11/12/2021 Today we take a look at the current state of homelessness in America and the best solution we currently know of to tackle the problem. Surprisingly simple, the best way to end homelessness is to give people homes. Be part of the show! Leave us a message at 202-999-3991 or email Jay@BestOfTheLeft.com Transcript BestOfTheLeft.com/Support (Get AD FREE Shows & Bonus Content) BestOfTheLeft.com/Refer Sign up, share widely, get rewards. It's that easy! CHECK OUT UNF*CKING THE REPUBLIC COFFEE! BestOfTheLeft.com/Advertise Sponsor the show! SHOW NOTES Ch. 1: Homelessness - Last Week Tonight - Air Date 11-1-21 With homelessness increasing nationwide, John Oliver takes a look at the way we discuss the unhoused, what policy failures are making the problem worse, and how we can help. Ch. 2: Should America Outlaw Homelessness - Thom Hartmann Program - Air Date 6-8-21 Homelessness is an epidemic in America “Housing First” is a the solution that has been embraced by countries around the world. Time to repudiate the failed Reaganomics experiment and take homelessness seriously again here in America. Ch. 3: Housing First - 99% Invisible - Air Date 12-8-20 In the 1980's, a psychologist named Sam Tsemberis was working with mentally ill homeless people on the streets of New York. Sometimes, when he thought it was necessary to keep someone safe, Sam would have people committed to a psychiatric hospital. Ch. 4: EXPOSED: These Rich Wall Street Billionaires Profit Off The Extreme Poverty They Caused! - Thom Hartmann Program - Air Date 10-15-21 We're seeing massive homelessness in cities across America because a handful of Wall Street billionaires want to make a killing - Will America remove housing from their clutches? Ch. 5: How Finland Ended Homelessness - Second Thought - Air Date 9-3-21 MEMBERS-ONLY BONUS CLIP(S) Ch. 6: The Criminalization of Poverty - Justice In America - Air Date 1-23-19 On this episode, we explore the countless ways the criminal justice system criminalizes poverty—and homelessness in particular. From what is considered criminal to how it is punished, people that are poor or in America are punished more. Ch. 7: Input from the unhoused may be crucial solution to homelessness in San Francisco - PBSNewsHour - Air Date 7-6-21 Correction: The introduction to this story stated that 35,000 people are without a place to live in San Francisco. In fact, that figure refers to the greater San Francisco Bay Area, including San Jose, Oakland and surrounding counties. FINAL COMMENTS Ch. 8: Final comments on the panicked flail of those who used to be ahead of the curve but have now been left behind MUSIC (Blue Dot Sessions): Opening Theme: Loving Acoustic Instrumental by John Douglas Orr Voicemail Music: Low Key Lost Feeling Electro by Alex Stinnent Activism Music: This Fickle World by Theo Bard (https://theobard.bandcamp.com/track/this-fickle-world) Closing Music: Upbeat Laid Back Indie Rock by Alex Stinnent Produced by Jay! Tomlinson Visit us at BestOfTheLeft.com Listen Anywhere! BestOfTheLeft.com/Listen Listen Anywhere! Follow at Twitter.com/BestOfTheLeft Like at Facebook.com/BestOfTheLeft Contact me directly at Jay@BestOfTheLeft.com
School boards across the country have faced increasingly hostile public input this year over the purported inclusion of Critical Race Theory in K-12 schools, indoor masking and a host of other topics—and the school board in Bend and La Pine has definitely seen more than its usual share of this type of input. In this podcast, Bend-La Pine Schools' board chair Melissa Barnes Dholakia and Superintendent Steve Cook talk about the role of school boards and how they manage public input, and offer an open invitation to members of the public to meet with them to discuss more about parental concerns.
Input expenses have been on the rise and have many farmers concerned to enter the 2022 growing season. During a recent State of the Economy event, NDSU experts offered some advice to producers about the next growing season. See omnystudio.com/listener for privacy information.
Insurance is a part of most crop producers game plan. However, the use of pasture and range insurance is not as often used by many ranchers. What are strategies we should consider for both pastures and crops? We talk to a veteran of the industry about his ideas and what he sees producers changing in a time of rising input costs. See omnystudio.com/listener for privacy information.
This week, we're sharing an idea that James Clear popularized in his book Atomic Habits. You can read more about his Systems vs Goals excerpt here.We talk through how the idea of focusing on your input instead of the outcome can drastically change how you feel about the tasks you need to do consistently (posting on social media, writing an email newsletter, working with clients, etc).
In this English podcast, learn two ways In which you can acquire English naturally so that you can speak with confidence. Not many learners are doing this and I believe that if you follow these methods, you'll be motivated more.Get your fluency book here: https://www.tofluency.com/book (it's FREE to download!)Here's the article on this: https://www.antimoon.com/how/input-intro.htm
Gravity Forms community experience manager James Giroux and host of “INPUT” shares the content marketing strategy of Gravity Forms in their new push to humanize their brand.In This Episode00:00 - Introduction04:07 - Greetings to James07:16 - Process of becoming a CEM14:26 - Like a good barbeque18:09 - Coming up with a strategy21:37 - Adjusting to generational shift23:41 - Using the WP tool26:00 - A collection of “Input” fields30:14 - Push back on conversion content34:10 - Where is the future audience37:16 - Be smart about content40:06 - Build content, plan and strategize48:30 - Growing from strength to strength53:03 - Practice helps58:30 - Bulk content if possible1:03:21 - Input expectations1:08:34 - Dealing with the haters1:12:54 - Connecting creativity w/purposeGet all links, resources and show notes at:https://joshhall.co/148
Ich spreche mit meinem Programmteilnehmer Dr. Alexander Bodtländer darüber, wie es ist, als Arzt alkoholabhängig zu sein. Und zwar als Arzt, der selbst in der Suchttherapie tätig ist. Hier kannst Du mein Buch "Ohne Alkohol: Die beste Entscheidung meines Lebens" kaufen: https://oamn.jetzt/buch Dr. Angela Kauffmanns Text zum Thema Sucht bei Fachleuten findest Du hier: https://oamn.jetzt/2021/10/angela-ein-hoch-tabuisiertes-thema/ Meine Onlinekurse "Die ersten 30 Tage ohne Alkohol mit Nathalie" und “Abstinenz stabilisieren” findest Du unter https://oamn.jetzt. Danke an meinen Vater für die Musik, an Katja Reister für den konzeptionellen Input, an Viktoriya Zayika fürs Foto und an Sebastian Sonnewend fürs Cover-Design.
In der 49. Folge von Startup Insider “read only” sprechen wir mit Anna Schnell, CEO von Mowomind, über das Buch “Die Modern Work Tour - eine Weltreise in die Zukunft unserer Arbeit”. Zusammen mit ihrem Mann und Co-Autor des Buches Nils Schnell war sie auf Weltreise um in den Austausch mit Menschen zu kommen die auf moderne Art und Weise arbeiten. Im Mittelpunkt der “Modern Work Tour” war dabei nicht China oder das bekannte Silicon Valley, sondern es waren Länder wie die Mongolei, Jordanien oder Namibia, die den großen Input geliefert haben. Mit der Tour auf insgesamt vier Kontinenten und ihrer Expertise als Keynote-Speakerin und Dozentin ist ein lebendiges Interview mit vielen Tipps, Einblicken und gesellschaftlichen Zusammenhängen zwischen den einzelnen Ländern und New Work entstanden - unbedingt reinhören!
In dieser Podcastfolge möchte ich darüber sprechen, warum ein Holistic Warrior ein High-Performer ist und warum ein Holistic Warrior ein Genuss für andere ist. Wie du vielleicht mitbekommen hast, nenne ich mein Coaching Unternehmen Holistic Warrior. Dieser Name ist für mich täglich Programm und Orientierung, denn ich verbinde damit, wer ich jeden Tag sein möchte und worauf es mir bei meiner täglichen Arbeit ankommt. Holistic Warrior ist für mich das Sinnbild eines idealen Menschen, für mich der ideale Mensch, der energievoll, mutig, visionär und innovativ ist, der seine Wahrheit lebt, der vorangeht und die Welt positiv mitgestaltet! In dieser Episode spreche ich darüber, warum ein Leben als Holistic Warrior mit einem selbstgewählten Lebens-Blueprint so viel mehr Freude macht und absolute Freiheit und echten Reichtum bedeutet.
Travel-Insider Podcast - DEIN Reise Podcast um besser zu fliegen
Endlich in der bequemen Business Class nach Dubai fliegen und nicht den vollen Preis bezahlen? Ja, das geht mit Punkten & Meilen und einem Prämienflug. Welches die besten Möglichkeiten sind, erfährst du in diesem Video. ► Miles & More Kreditkarte: https://www.travel-insider.de/mmgold ► Amex Gold Kreditkarte: https://www.travel-insider.de/amexgold ► Amex Platinum Kreditkarte: https://www.travel-insider.de/amexplatinum ▬ Über diesen Kanal ▬▬▬▬▬▬▬▬▬▬▬▬ Mit "Travel-Insider" hast du genau den richtigen Kanal für mehr Komfort und Luxus beim Reisen gefunden. Erfahre hier auch, warum es auch für Dich Sinn macht, endlich Business Class zu fliegen und dabei nur den Economy-Preis zu bezahlen. Dann bist du hier genau richtig! Ich, Dominik Reichert, biete dir wöchentlich neuen Input und neue Tipps, um deine Reisen auf das nächste Level zu bringen. ▬ Weitere Infos zum Travel-Insider ▬▬▬▬▬▬▬▬▬▬▬▬ ► Viele weitere Informationen & verschiedene Deals findest du auf meiner Website: https://www.travel-insider.de ► Hier kannst du den kostenlosen Upgrade-Report downloaden https://www.travel-insider.de/upgrade-report ► Feedback und Fragen an podcast@travel-insider.de ▬ Meine Basis-Ausrüstung ▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Lufthansa Flugbuchung: https://www.travel-insider.de/lufthansa ► Miles & More Kreditkarte: https://www.travel-insider.de/mmgold ► Mikrofon: https://amzn.to/3fmpm8P (Bei den Links handelt es sich um bezahlte Affiliate-Links. Dir entstehen dadurch keine Zusatzkosten.) ▬ Noch mehr Videos ▬▬▬▬▬▬▬▬▬▬▬▬ ► Alle Videos von "Travel-Insider": https://www.youtube.com/channel/UCSjv8FRKjOQfCXmxNEwrQLg ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Instagram: https://www.travel-insider.de/insta ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ #Prämienflug #Meilen #Lufthansa #Milesandmore
Als die Azteken und Inka in Mexiko und Peru von den Konquistadoren besiegt und unterworfen worden waren, glaubten die Spanier, den Widerstand aller indigenen Völker Südamerikas endgültig gebrochen zu haben. Betraut mit der Aufgabe, die Bevölkerung Chiles zu unterwerfen, zog ein Vertrauter Pizarros, Pedro de Valdivia, in den chilenischen Süden. Gewaltsam wurde ein Volk nach dem anderen unterdrückt. Als jedoch der Konquistador 1546 den Río Bío Bío erreichte und den Versuch wagte, den Fluss zu überqueren, wurde er von einem unerschrockenen Feind angegriffen und zurückgedrängt. Mit dem Vormarsch der Spanier formierte sich südlich des Rio BioBio ein organisierter Widerstand, wie ihn die Spanier noch nicht erlebt hatten und der die Geschichte Chiles bis in die Gegenwart erschüttert. Das Folgenbild zeigt den Toqui Lautaro (1535-1557). ......... Literatur zur Folge: Kaltmeier, Olaf: Marichiweu! Zehnmal werden wir siegen! Eine Rekonstruktion der aktuellen Mapuche-Bewegung in Chile aus der Dialektik von Herrschaft und Widerstand seit der Conquista, Münster 2004. Latcham E., Ricardo: Die Kriegskunst der Araucanos, Hamburg 1988. ......... Unsere Quellen findet ihr hier, auf Instagram und auf unserer Website His2Go.de. Ihr könnt uns dabei unterstützen, weiterhin jeden 10., 20. und 30. des Monats eine Folge zu veröffentlichen. Folgt uns bei Spotify, Google Podcasts, Podimo und Instagram und bewertet uns auf Apple Podcasts oder über eure Lieblings-Podcastplattformen. Über einen Spendenlink auf unserer Website könnt ihr uns finanziell unterstützen, damit wir Literatur und neue Technik für den Podcast anschaffen können. Wir freuen uns über euer Feedback, Input und Vorschläge zum Podcast, die ihr uns über das Kontaktformular auf der Website, Instagram und unserer Feedback E-Mail: feedback.his2go@gmail.com zukommen lassen könnt. An dieser Stelle nochmal vielen Dank an jede einzelne Rückmeldung, die uns bisher erreicht hat und uns sehr motiviert. ......... Music from https://filmmusic.io “Sneaky Snitch” by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)
Taking care of ourselves shouldn't feel like one more thing on our To Do list. But it can feel like that sometimes. In this episode I wanted to share how I have shifted my mindset around practices that 'fill up my tank', especially at super busy times where lots of output is required! Want to see how this can work in your life too? Why not try out a month of Messy Luminous Yoga? Come drink the Kool-Aid, as us American kids of the '80s would say ;) https://mailchi.mp/sarahbhunt/messyluminousyoga
SST175: Angst vorm Frauenarzt - Was tun? "Kathrin, ich hab total Angst vor dem Frauenarzt und traue mich nicht, zu den Untersuchungen zu gehen. Was soll ich tun?" Diese Frage habt ihr mir über meine Social-Media-Kanäle gestellt. Ich selbst bin in den letzten zweieinhalb Jahren zu einer echten Expertin geworden, was Frauenarzt-Besuche betrifft. Denn durch meine Endometriose- und Zysten-Diagnose im Sommer 2019 musste ich einfach richtig oft zum Frauenarzt. Das war natürlich schon ziemlich anstrengend, aber ich hab dadurch auch eine Menge über mich selbst gelernt und erfahren: Auch auf dem Gynäkologenstuhl habe ich als Patientin das Recht, meine Bedürfnisse und Grenzen zu äußern. Darum geht es in der heutigen Folge! Ich hoffe, ich kann dir damit etwas von deiner Angst vor dem Frauenarzt nehmen. Du willst noch mehr???
Let's talk Medicare...This is one of the many issues Senator Joe Manchin is having with Biden's Social Safety net package as Democrats want to expand on Medicare… Dr. Raymond Ward and Utah Representative calls in to discuss See omnystudio.com/listener for privacy information.
CT Book Share: รีวิวหนังสือ The Power of Input ศิลปะของการเลือก-รับ-รู้ ชวนทุกคนไปรู้จักหนังสือที่จะช่วยให้คุณเลือกรับความรู้ที่ดีเพื่อให้เหมาะกับโลกที่เต็มไปด้วยข้อมูล
Your Monday NewsLink for the week of October 25, 2021. This week's headlines come from the City of Lee's Summit, Downtown Lee's Summit, the Lee's Summit R-7 School District, UCM-Lee's Summit and more.
EP 222 Family Business – Motivation to Move You Into those Difficult Discussions Too often we avoid the tough conversations. Our Lizard Brain gives us these reasons and exuses that feel like facts…….in working with family businesses for about 25 years I can tell – rarely are these facts. Here's a few of the most common “Reasons” I hear……. Reasons & Excuses that Feel Like Facts We're Fine We're too Busy We Love One Another I don't Know What I Want It Will Never Happen Anyway We'll Do Future Planning Soon I Don't Want Them to Be Mad at Me No Need to Rock the Boat-All Will Be Fine We all Get Along Well – We'll Work it Out Soon Recently had a family business leader – Next Gen tell me “We're Getting Along “ Which got me thinking……- But at What Cost? Assuming Rather than Asking Frustrations Not Addressed Ideas & Innovations Not Heard Personal Goals Not Shared Decisions Made w/o Input Boundaries Created Not Communicated Not Kept Disability Divorce Death Distress Disagreement The 5 D's That Can Drive Business Direction if You Don't And, if you think it feels uncomfortable having these conversations at the time of your choosing – Imagine what it's like having them in the middle of Crisis OR Conflict I, unfortunately, have seen it happen many times. 6 Siblings MyImpactAcademy.com/Join
Michael präsentiert im SHOCK2 Wochenstart zum 157. Mal das Serviceformat für die SHOCK2-Community! Mit dabei Tristan von Siren Games mit einem neuen Brettspiel-Tipp und das Audio-Review zu Asterix und der Greif. Wir wünschen euch viel Spaß beim Hören und freuen uns auch diesmal besonders auf euren Input, Ideen & Feedback im Forum. Links zu Sendung: SHOCK2 Magazin: https://mag.shock2.info/ Partner Siren Games: https://www.sirengames.at/ SW LEGION: Grundspiel - DE https://www.sirengames.at/de/SW-LEGION:-Grundspiel---DE_1_14485 Shock2 Community Wichteln 2021 http://community.shock2.at/t/shock2-community-wichteln-2021/10217 SHOCK2 unterstützen: http://community.shock2.at/t/moeglichkeiten-shock2-zu-unterstuetzen/8350
Folge 240: Honeymoon Special Teil 2 (solo)Im zweiten Spezial rufe ich Hörer Stefan im Urlaub an. Er berichtet wie er alten Omas den Bademantel in der Sauna geklaut hat.Und ich behandele den Input von Nico zum Thema Zukunftangst und ob man in diese Welt Kinder setzen sollten. Soviel vorab: Auf jeden Fall!Alle Inhalte und Empfehlungen auf http://www.bensprichtpodcast.deSpotify: https://spoti.fi/2QgN7R9Exklusive Inhalte: https://www.patreon.com/bensprichtpodcastSchick mir ein Danke via Paypal an: https://www.paypal.me/bensprichtpodcastGeschenkliste: https://amzn.to/36Z7JpME-Mail Newsletter Anmeldung:https://bit.ly/2PIz9Ze
Die medialen Berichte über das RS-Virus überschlagen sich. Dabei ist das Virus nichts Neues- wir haben jeden Winter damit zu tun und fast jeder 2Jährige hat bereits eine Infektion durchlaufen. Dieses Jahr kommt die RSV-Welle aber besonders früh und die Saison wird nach dem Corona-Jahr vermutlich besonders heftig werden. Deswegen bespreche ich in der heutigen Folge, wie du die Infektion erkennst, wann sie gefährlich wird und wann du zu, Kinderarzt gehen solltest. Wie hat dir die Folge gefallen? Du findest diesen Podcast bei Spotify, iTunes und Deezer. Ich freu mich über deine Gedanken, Fragen und Input auf meinem Instagram Kanaloder auf meiner Website. Hier geht es zu unseren Online Kursen: https://www.kinderleibundseele.com/online-kurse Wenn dir die Folge gefallen hat, freu ich mich riesig über eine Bewertung bei Apple Podcasts ! Teile diese Folge gerne mit anderen Eltern, die nach Antworten auf Fragen zur Kindergesundheit suchen. Disclaimer: Sämtlich Inhalte auf kinderleibundseele dienen der allgemeinen Information. Alle Informationen auf dieser Seite sind sorgfältig recherchiert, können jedoch in medizinischer Hinsicht keinerlei Anspruch auf Vollständigkeit, Aktualität, Richtigkeit und Ausgewogenheit erheben. Insbesondere sind sie in keiner Weise ein Ersatz für professionelle Diagnosen, Beratungen oder Behandlungen durch Ärzte/Ärztinnen. Genauso wenig dürfen die hier angebotenen Informationen als Grundlage für eigenständige Diagnosen sowie Behandlungen oder Änderungen an einer bereits empfohlenen Behandlung dienen. Konsultiere bei gesundheitlichen Fragen oder Beschwerden immer den behandelnden Arzt/behandelnde Ärztin. kinderleibundseele übernimmt keine Haftung – weder direkt noch indirekt – für Schäden oder Unannehmlichkeiten, die sich aus der Nichtbeachtung dieser Hinweise ergeben.
Travel-Insider Podcast - DEIN Reise Podcast um besser zu fliegen
Diese Frage erreicht mich doch relativ häufig, nämlich, ob auf Prämienflügen auch Meilen gesammelt werden können. Also sowohl Statusmeilen als auch Prämienmeilen. Genau das klären wir in der heutigen Folge. Miles & More Kreditkarte: https://www.travel-insider.de/mmgold ▬ Über diesen Kanal ▬▬▬▬▬▬▬▬▬▬▬▬ Mit "Travel-Insider" hast du genau den richtigen Kanal für mehr Komfort und Luxus beim Reisen gefunden. Erfahre hier auch, warum es auch für Dich Sinn macht, endlich Business Class zu fliegen und dabei nur den Economy-Preis zu bezahlen. Dann bist du hier genau richtig! Ich, Dominik Reichert, biete dir wöchentlich neuen Input und neue Tipps, um deine Reisen auf das nächste Level zu bringen. ▬ Viele weitere Infos ▬▬▬▬▬▬▬▬▬▬▬▬ Viele weitere Informationen & verschiedene Deals findest du auf meiner Website: https://www.travel-insider.de ► Hier kannst du den kostenlosen Upgrade-Report downloaden https://www.travel-insider.de/upgrade... ► Youtube: https://www.youtube.com/channel/UCSjv8FRKjOQfCXmxNEwrQLg ► Feedback und Fragen an podcast@travel-insider.de ▬ Mein Equipment ▬▬▬▬▬▬▬▬▬▬▬▬▬ Lufthansa Flugbuchung: https://www.travel-insider.de/lufthansa Miles & More Kreditkarte: https://www.travel-insider.de/mmgold Mikrofon: https://amzn.to/3fmpm8P (Bei den Links handelt es sich um bezahlte Affiliate-Links. Dir entstehen dadurch keine Zusatzkosten.) ▬ Social Media ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ ► Instagram: https://www.travel-insider.de/insta ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬
Alexander ist noch einmal Papa geworden – im übertragenden Sinne: Am Montag ist sein Buch und Hörbuch mit dem Titel „Das Astrologische Luftzeitalter“ erschienen. Er und Kathie sind jetzt schon überwältigt von dem tollen Feedback, das sie erreicht hat. Die zwei Endprodukte in den Händen zu halten – das ist ein ganz besonderes Gefühl. Hörerin Johanna fragt: Kann Traumatisierung als besondere Konstellation im Horoskop markiert sein? Und spricht damit gleich eine der spannendsten und heikelsten Themen der Astrologie an. Epigenetik, Transgenerationale Traumata, Energie – häufig entstammen die Dinge, die wir fühlen, der Vergangenheit und wurden über Generationen weitergegeben. Dies leitet uns gleich zur ersten Konstellation dieser Woche weiter, die heute zwischen Mars und Pluto stattfindet: Mars steht für die Fähigkeit zu attackieren, sich zu behaupten oder zu verteidigen. Pluto ist wiederum die höhere Oktave des Mars: Es entsteht ein Staumoment der Aggression, der oft etwas mit Trauma zu tun hat. Der heutige Tag lädt dazu ein, diesen unterbewussten Wutzuständen auf den Grund zu gehen: Woher kommen sie? Und wie gehen wir mit ihnen um? Was hier eindeutig helfen kann: Bewegung und in die körperliche Umsetzung zu gehen.Samstag findet der Übergang von der Waage zum Skorpion statt, bedeutet konkret: Herausfinden, was nicht im Gleichgewicht ist und die Konsequenzen daraus ziehen. Kathie fallen da gleich mehrere aktuelle gesellschaftliche Ereignisse ein, in denen sich das Ungleichgewicht widerspiegelt: ist das Zufall? Alexander betont, dass diese Konstellation dem Zeitpunkt Inhalt und Bedeutung zuspricht; mal wieder meldet sich hier der Epochenwechsel zu Wort. Sonntag begegnen wir einem Aspekt zwischen Merkur und Uranus. Ein guter Zeitpunkt, um uns zu fragen: Wie kommunizieren wir miteinander? Ist unsere Dialog-Kultur noch vorhanden? Toleranz als Basis macht ein Miteinander schließlich erst möglich. Dieser Aspekt kann tatsächlich Freude machen und durch neuen Input zu Bereicherungen führen. Mittwoch entsteht ein Aspekt zwischen Venus und Neptun und erinnert uns daran, uns in Demut zu üben. Ein grandioser Zeitpunkt, für Dankbarkeitsrituale, erinnert uns Kathie. Ein charmantes Finale der Woche findet am Donnerstag statt: in einer Venus-Jupiter-Konstellation werden wir daran erinnert, wie wichtig Großzügigkeit ist. Der perfekter Tag, um Menschen einzuladen, um die Freude an der Freude zu teilen. Jetzt "Das astrologische Luftzeitalter" vorbestellen: https://bit.ly/3lymMjo. Und das Hörbuch: https://bit.ly/3ACmX1z Habt ihr Rückmeldung zum Astropod? Schreibt uns gerne an astropod@astropod-schlieffen.de, auf Instagram oder Facebook. Mehr von Kathie gibt es hier: https://linktr.ee/kathie_kleff. Viel Spaß mit dem Astropod. See acast.com/privacy for privacy and opt-out information.
Hey du wundervoller Mensch, in der heutigen Episode erkläre ich dir: welche 6 Schritte du ab sofort in deinen Alltag einbinden kannst, um Klarheit, Vertrauen und Flow zu entwickeln, welcher dafür sorgt, dass du nachhaltig das manifestierst, was du dir wünschst welche 2 Bücher ich jedem Beginner empfehle, die mein Leben und das Verständnis für das Gesetz der Anziehung massiv verändert und geformt haben welche Tools es sind, die sowohl Beginnern, als auch Fortgeschrittenen Mindset Pro‘s dienen, eine noch bessere Version von sich zu werden, um im Leichtigkeit und Gelassenheit Wünsche zu manifestieren. Und das nicht nur 3 Mal im Jahr, sondern ein Leben lang.NEWS NEWS NEWS:Eine ganz neue News möchte ich heute ebenso mit dir teilen: Wenn du unseren Podcast liebst, gerne hörst, an jemanden weiterempfehlen möchtest und in den Genuss eines privaten Coaching Calls mit mir kommen möchtest, dann ist das deine Chance in den Lostopf, einer der schönsten Verlosungen zu kommen. Unter allen, die uns eine schriftliche Bewertung bei iTunes ( Apple ) hinterlassen, verlosen wir 10 X einen exklusiven Platz in einem meiner privaten Coachingcalls. Wie du mitmachen kannst ist einfacher als einfach. 1. Gehe zu iTunes und gebe uns eine schriftliche Bewertung für den High Vibe Podcast 2. Mache einen Screenshot von deiner eingereichten schriftlichen Bewertung, so dass wir erkennen können, dass du eine Bewertung abgegeben hast 3. Sende diesen Screenshot an folgende Email Adresse: podcast@nousame.com 4. Die Gewinner werden Ende November via Email benachrichtigt und können im Dezember an einem Live Coachingcall teilnehmenSolltest du im Dezember 2021 bereits Mitglied im High Vibe Club sein, trotzdem eine schriftliche Bewertung abgeben wollen und bei der Auslosung gewinnen, dann erhältst du natürlich eine andere Art von Geschenk, da du ohnehin die Möglichkeit des Live Calls hast, weil du Mitglied sein wirst ♥️ Kostenlose 3 Tage - HIGH VIBE Masterclass! Melde dich JETZT an https://bit.ly/3-Tage-High-Vibe-MasterclassTeile diese Episode gerne mit deinen Freunden, Kollegen oder einer anderen Person, die diese Episode hören soll, um ihrer besten Zukunftsversion ein grosses Stück näher zu kommen.Wenn du einen Screenshot der Episode machst, dann tagge uns unbedingt auf Instagram, damit wir uns persönlich bei dir bedanken können. Folge Diana auf Instagram für alle juicy Nuggets und sehr viel Input zu Manifestation, Mindset & Money auf Instagram http://www.instagram.de/Diana_DeloFolge Dali auf Instagram und hole dir London Vibes nach Hause http://www.instagram.de/perfectscornerHast du noch mehr Fragen an uns? Her mit ihnen per DM auf Instagram oder via Email an hello@nousame.com
This week Mary shares tips you need to keep in mind whenever you are gathering input from stakeholders - whether that's when you're in a strategic planning process or for some other reason. And Mary has a gift for you: free training: 3 Mistakes Nonprofit Leaders Make Orienting Board Members and how to avoid them- just click on that to get it. Mary's book is now available on Amazon or wherever books are sold: Love Your Board! The Executive Directors' Guide to Discovering the Sources of Nonprofit Board Troubles and What to Do About Them. Be sure to subscribe to Inspired Nonprofit Leadership so that you don't miss a single episode, and while you're at it, won't you take a moment to write a short review and rate our show? It would be greatly appreciated! Let us know the topics or questions you would like to hear about in a future episode. You can do that, and follow us, on Facebook. Connect with Mary! LinkedIn: https://www.linkedin.com/in/maryhiland Inspired Nonprofit Leadership Facebook Group: https://tinyurl.com/inspirednonprofitleadership Company Facebook: https://www.facebook.com/hilandconsulting Website: https://hilandconsulting.org
Heute gebe ich Dir schonmal 10 der 30 Tipps für Social Media Postings! ———————————————————————————————————— Schaue auch gern hier vorbei: Homepage
Die beiden Polarforscher Scott und Amundsen haben sich mit ihrem Wettlauf durch die Antartkis unsterblich gemacht. Ihr Ziel war es, jeweils als erster Mensch den geographischen Südpol zu erreichen. Beide wollten mit der ehrgeizigen Mission ihrem Land zu großem Ruhm verhelfen, doch aus der Antartkis kehrte 1912 nur eine der beiden Expeditionen lebend wieder zurück. Der Brite Scott führte seine Männer der Terra-Nova-Expedition letztlich ins Verderben und wir zeichnen ihre Geschichte nach... Das Folgenbild zeigt die Gruppe um Scott nach der Ankunft am geographischen Südpol. Hier geht es zur virtuellen Tour durch Scotts "letzte Hütte": https://www.antarktis.net/fotos-panoramen-videos/antarktis-panoramen/mcmurdo-sound/kap-evans.html ......... Literatur zur Folge: Jones, Max: The Last Great Quest. Captain Scott's Antarctic Sacrifice, Oxford/ New York 2003. Solomon, Susan: The Coldest March. Scott's Fatal Antarctic Expedition, New Haven/ London 2001. ......... Unsere Quellen findet ihr auf Instagram und auf unserer Website His2Go.de. Ihr könnt uns dabei unterstützen, weiterhin jeden 10., 20. und 30. des Monats eine Folge zu veröffentlichen. Folgt uns bei Spotify, Google Podcasts, Podimo und Instagram und bewertet uns auf Apple Podcasts oder über eure Lieblings-Podcastplattformen. Über einen Spendenlink auf unserer Website könnt ihr uns finanziell unterstützen, damit wir Literatur und neue Technik für den Podcast anschaffen können. Wir freuen uns über euer Feedback, Input und Vorschläge zum Podcast, die ihr uns über das Kontaktformular auf der Website, Instagram und unserer Feedback E-Mail: feedback.his2go@gmail.com zukommen lassen könnt. An dieser Stelle nochmal vielen Dank an jede einzelne Rückmeldung, die uns bisher erreicht hat und uns sehr motiviert. ......... Music from https://filmmusic.io “Sneaky Snitch” by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)
You can get your transcripts here - https://www.helpmyrussian.com/courses/listen-to-russian The stories I've created are written in a casual tone and are absolutely natural. But at the same time adapted to a a beginners level( A1 level ), so that you can practise without overwhelm! Input is good, BUT it's very important that the material is at your level! The difficulty of the text doesn't depend on the speed of the text, or not even the vocabulary in the text, it depends on the constructions that are used in the text. That's why in these podcasts there are only 3 Cases used ( Nominative, Prepositional, and Accusative), and a limited number of grammatical structures. It's very important that you have a transcription in front of you, and you can keep listening to the audio at full speed. Even if you are a beginner! So many times people learn with a book, read texts silently, or listen to slow podcasts, and oops! - when a native speaker says something simple, you don't even recognise this word at all
California isn't the only party unhappy with the Equal Employment Opportunity Commission (EEOC) and its proposed $18 million settlement with Activision Blizzard. The Communications Workers of America (CWA), a labor union that has already helped Activision employees file one charge with the National Labor Relations Board (NLRB), has decided to bring 31 separate complaints of its own. Are they legitimate? Are they not? Either way they're certainly very focused...on making sure Activision Blizzard leaves open the door for unionization. We're not sure they have standing, but they definitely want a seat...in Virtual Legality. CHECK OUT THE VIDEO AT: https://youtu.be/uK57WIicIHI #Activision #California #CWA *** SUPPORT THE CHANNEL PATREON - https://www.patreon.com/VirtualLegality STREAMLABS - https://streamlabs.com/richardhoeg STORE - https://teespring.com/stores/hoeg-law-store *** CHAPTERS 00:00 Introduction 02:00 The CWA Intervenes 06:43 Notice and Waivers (1-2) 15:47 Damage Caps and California (3-4) 22:35 Scope, Definitions, and Non-Admissions (5-10) 30:51 Consultants, Claimants, and Complaints (11-15) 35:55 A Problem of Privilege (16) 38:13 Input, Input, Input (17-21) 43:28 Lawyers are Expensive (22) 47:16 More Input and a Section 7 Parade (23-28) 55:23 Training and Understanding (29-31) 57:13 Conclusion *** Discussed in this episode: "Everybody vs Activision Blizzard: A Legal View" YouTube Playlist - Hoeg Law https://www.youtube.com/playlist?list=PL1zDCgJzZUy9PBxr5dNcoQLh2erIt2XrZ "Activision Lawsuit - California Calls EEOC Liars, Union Joins Fight (VL558)" YouTube Video - October 12, 2021 - Hoeg Law https://youtu.be/fwM36bFow_Q CWA Request for Fairness Hearing October 12, 2021 https://storage.courtlistener.com/recap/gov.uscourts.cacd.832570/gov.uscourts.cacd.832570.20.0.pdf "Employees of Activision Blizzard File Unfair Labor Practice Charge Against the Gaming Company" CWA Press Release - September 14, 2021 https://cwa-union.org/news/releases/employees-of-activision-blizzard-file-unfair-labor-practice-charge-against-gaming EEOC v Activision Blizzard Proposed Consent Decree https://investor.activision.com/consent-decree-with-EEOC EEOC v Activision Blizzard Opposition to Intervention - Exhibit A (EEOC) https://storage.courtlistener.com/recap/gov.uscourts.cacd.832570/gov.uscourts.cacd.832570.15.6.pdf EEOC Website https://www.eeoc.gov/settlement-standards-and-procedures#section2f https://www.eeoc.gov/laws/guidance/enforcement-guidance-compensatory-and-punitive-damages-available-under-sec-102-cra https://www.eeoc.gov/employers/resolving-charge https://www.eeoc.gov/federal-sector/settlement-agreement "Right of employees as to organization, collective bargaining, etc." 29 USC 157 (NLRA Section 7) https://www.law.cornell.edu/uscode/text/29/157 *** "Virtual Legality" is a continuing series discussing the law, video games, software, and everything digital, hosted by Richard Hoeg, of the Hoeg Law Business Law Firm (Hoeg Law). CHECK OUT THE REST OF VIRTUAL LEGALITY HERE: https://www.youtube.com/playlist?list=PL1zDCgJzZUy9YAU61GoW-00K0TJOGnPCo DISCUSSION IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS LEGAL ADVICE. INDIVIDUALS INTERESTED IN THE LEGAL TOPICS DISCUSSED IN THIS VIDEO SHOULD CONSULT WITH THEIR OWN COUNSEL. *** Twitter: @hoeglaw Web: hoeglaw.com
Power & Politics for Friday, October 15th with Ontario Progressive Conservative MPP David Smith, Ontario NDP MPP Marit Stiles, Ontario Liberal MPP John Fraser, British Conservative MP Andrew Percy, Ontario Medical Association President Dr. Adam Kassam, Nova Scotia Conservative MP Chris d'Entremont and the Power Panel.
Input prices are on the rise. How can we reduce those costs while increasing yields and profits? This week's guest provides his tech and agronomy keys to help do just that! See omnystudio.com/listener for privacy information.
10-14-21 • Markets still digesting the report • How much demand will affect the trade? • Growing crops in South America • Basis continues to rally • Improving ethanol margins • Marketing through harvest • Input costs for ‘22 • Triple digit gains in live & feeder cattle • Export market trade for livestock
SST174: Sexuelle Lust vs. Unlust - Wenn einer mehr will als der andere "Wieso will er mich nicht, wenn ich Lust habe?", "Warum versteht sie nicht, dass ich auch mal Zeit für mich brauche?", "Wieso törnt es sie nicht an, wenn ich mit ihr schlafen will?", "Warum will er ständig? Sieht er nicht, dass es mir zu viel ist?" Wenn zwei Menschen mit unterschiedlichen sexuellen Bedürfnissen in einer Partnerschaft leben, sind Konflikte vorprogrammiert. Gerade, wenn einer der beiden Partner wesentlich mehr Lust auf Sex hat als der andere, kann das oft zu Unverständnis, Streit oder Enttäuschung führen. Viele Paare denken dann: "Anscheinend passen wir nicht zueinander. So kann es nicht weitergehen." Wenn du dieses Problem kennst, dann ist die heutige Podcastfolge sehr wertvoll für dich. Denn ich spreche heute darüber, wie ihr eine Dysbalance in der sexuellen Lust für euch gelöst kriegt. Ich kenne das Thema sehr gut, es hat mich selbst jahrelang beschäftigt. (Hör dazu gern die Folge SST173!) Und: Du kannst beruhigt sein - in so gut wie jeder Langzeit-Partnerschaft gibt es Phasen, wo eine Person mehr Lust auf Sex hat als die andere. Das heißt nicht, dass mit eurer Beziehung was nicht stimmt oder ihr jetzt Schluss machen müsst. Es heißt einfach, dass ihr vor einer neuen Herausforderung steht, die ihr jetzt gemeinsam lösen dürft. Wenn ihr euch dabei Hilfe oder Begleitung wünscht, meldet euch gerne bei mir! In einem kostenlosen Erstgespräch finden wir heraus, welches meiner Angebote euch in eurer derzeitigen Situation am besten unterstützt. PS: Die Bücher und Spiele, die ich in der heutigen Folge erwähne, sind meine persönlichen Empfehlungen und keine bezahlte Kooperation. Wenn sie euch interessieren, hier nochmal eine Liste für euch: "Die 5 Sprachen der Liebe" - Buch von Gary Chapman "Die Wahrheit beginnt zu zweit" - Buch von Michael Lukas Möller "HerzSprechen" - Brettspiel von Ralf Grabowski "90 Fragen, die verbinden. Für mutige Gespräche zu zweit" - Kartenset von beherzt.net Du willst noch mehr???
Human Design: Entdecke deine individuellen Entwicklungspotenziale Laura Milde, bekannt als die "wilde Milde" - wild entschlossen für den Lebenserfolg "ihrer Menschen". 20 Jahre Heilpraktiker-Praxis und 20 Jahre Coaching-Praxis - sowie Autorin von 8 Büchern - da steckt eine Menge an Lebenserfahrung und -Weisheit drin. Als Human Design-Analytikern und -Coach nutzt Laura eine moderne, höchst exakte Persönlichkeits- und Talente-Analyse, die individuelle Entwicklungspotentiale aufzeigt. Was Human Design ist und aus welchen Elementen es besteht Human Design besteht aus ehrwürdigen Weisheitslehren, wie dem i Ging, der Kabbala, der Chakren-Lehre, sowie moderner Wissenschaft, wie Quanten-Physik, Bio-Chemie und Genetik. Durch Human Design kann man die eigene Körperweisheit erkennen und der eigenen Wahrnehmung (wieder) vertrauen lernen. Human Design: Wobei es dich unterstützen kann Das Human Design System hilft zu erkennen, dass ein erfolgreiches, erfülltes Leben weniger eine Frage von Anstrengung, harter Arbeit und dem Vermeiden von Fehlern ist, sondern durch auslesen der eigenen Genetik endlich der Weg glasklar wird, der Dich in Zufriedenheit, Frieden, Erfolg und Selbstliebe führt. Das, was wir unseren Haustieren zugestehen (artgerechte Haltung) ;-) sollten wir auch für uns selbst in Anspruch nehmen. Es ist gefühlt wie Tag und Nacht, wenn man beginnt, zu de-konditionieren, wie das im Human Design genannt wird und man zu seiner ureigensten, unverwechselbaren Genialität findet. Wir Menschen sind komplex und Human Design ist es auch. Deshalb ist es ein Prozess, der mit dem Auslesen der eigenen genetischen Anlagen beginnt und kann nicht einfach aus Büchern gelernt werden. Der Verstand ist darauf konditioniert, durch Input von Fakten unser Leben zu kontrollieren. Welch ein kosmischer Witz das ist, wird durch Readings klar, wie das Auslesen der individuellen Parameter genannt wird. PS.: der grösste Benefit ist jedoch, sich selbst zu kennen, zu lieben und zu achten - und endlich (!) für sich selbst einzustehen - egal was andere dazu sagen - wie das gelingt? frag einfach die Laura ;-) Dein größter Fehler als Unternehmer?: Statt auf mich selbst, auf die "guten Ratschläge" anderer zu hören... mich im Marketing "zu verkaufen" - statt einfach echt, authentisch, ich selbst zu sein. Deine Lieblings-Internet-Ressource?: Dropbox Mein wichtigstes Tool ist Zoom, da ich alle Sitzungen, Readings, Coachings via Video-Konferenz abhalte. Und ohne Dropbox wäre ich auch verloren ;-) Deine beste Buchempfehlung: Buchtitel 1: Buchtitel 2: Kontaktdaten des Interviewpartners: https://www.wildemilde.com info@laura-milde.com whatsApp +4917696365385 Goodie: Body Graph per email anfragen (kostenlos) +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ Mehr Freiheit, mehr Geld und mehr Spaß mit DEINEM eigenen Podcast. Erfahre jetzt, warum es auch für Dich Sinn macht, Deinen eigenen Podcast zu starten. Jetzt hier zum kostenlosen Podcast-Workshop anmelden: http://Podcastkurs.com +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ So fing alles an. Hier geht´s zur allerersten Episode von TomsTalkTime.com - DER Erfolgspodcast. Und ja, der Qualitätsunterschied sollte zu hören sein. Aber hey, dass war 2012... :) 001 – Willst Du mehr Erfolg im Leben? Erfolg kann man lernen. Jeder. Im Erfolgspodcast TomsTalkTime von Tom Kaules lernst Du in inspirierenden Interviews und einzelnen Storys die Strategien von erfolgreichen Unternehmern und Prominenten. Du lernst in Experten-Interviews wie erfolgreiche Menschen erfolgreich geworden sind und warum sie erfolgreich bleiben. Wie sie den richtigem Umgang mit Erfolg und auch den Umgang mit Niederlagen gelernt haben. Das richtige Mindset ist wichtig, um richtig viel Geld zu verdienen, glückliche Beziehungen führen, mit sich selbst im Einklang zu sein und dadurch Beruf und Familie bestens miteinander vereinbaren zu können. Einschalten. Zuhören. Sich motivieren und Inspirieren. Lernen. Tun. Erfolg haben.
Counter Point This show is a counter point to: hpr3414 :: Critical Thinking may make You Critical of the Covid Crisis Some time ago, I did some Hacker Public Radio episodes in which I ostensibly demonstrated how to create a PDF with Scribus. Secretly, I was actually demonstrating how unexpected payloads could be embedded into a PDF. Did the PDF I uploaded as part of that episode no longer contain a payload if the listener who downloaded it wasn't aware that the payload existed? I've been diagnosed by educators as a "life long learner," which as far as I can tell is a buzzword referring to someone who takes pleasure in learning new things. In our world of technology, dear listener, I think this term is just "hacker." And that's appropriate, because this is Hacker Public Radio you're listening to now, and listeners of this show tend to be people who enjoy learning and exploring new ideas, taking apart gadgets to see what makes them tick, reverse engineering code and data to understand how it gets processed, and so on. The thing about being a hacker or a life-long learner is that there's a lot of stuff out there that wants to be hacked, or learnt. And it turns out that it's just not possible to learn everything. Sometimes, you're out of your depth. It can be tricky to recognize when you're out of your depth, and I think there's a certain learn-able skill to knowing that you don't know something. There's a lot of value to this skill, because when you can recognize you don't have expertise on something, you're able to look around you and find someone who has. That's significant because you can learn from someone with expertise. In my own humdrum life, before getting a full-time job at a tech company, I was commissioned on several occasions to build out infrastructure for a video game development project, an indie radio station, a few different multimedia projects, and so on. When I took on those roles, I became the resident expert. People turned to me for the authoritative word on what technological solutions should be used. When I told them, they were more or less obligated to listen, because that was the role I'd been hired for. If they were to ask me what a workstation should run, and I said Linux, but they bought a Mac instead, then my role would be unarguably redundant. They could just as easily type the question into a search engine on the Internet, and ignore the result. Or they could roll a die, or whatever. In those cases, though, it's a question of my opinion compared to someone else's opinion. Both are valid. Because I was the architect, my opinion mattered more to the long-term plan, but if the long-term plan were to change from having a highly-available cluster for fast 3d model rendering to having workstations with a familiar desktop, then my opinion would be less valid. But there are some areas in life where opinions don't matter. Specifically, that area is science. But what is science, anyway? People talk about science a lot, but it took me a long time, especially as someone who largely came from an artistic background, to comprehend the significance of the term, much less how it worked. Forget about all the high school classes and pop dietitians and physicists. Science is a framework. It's a set of principles designed to help our human brains hack the world around us in a methodical and precise way. Instead of letting our opinions, which may or may not be relevant, influence conclusions and decisions we make, science looks at the results of controlled input and output. Wait a minute. "Input and output"? Those are words I understand. Those are computer terms! Yeah it turns out that computers are the product of science, and in fact building computers and programming computers is a form of Computer Science. Those are just words we made up, but they reveal a lot about what we computer hackers do all day. Computers don't understand the influence of opinion, or your force of will, or the power of faith. They just take input and produce output. They do this very reliably. I don't know whether you've ever tried, but it's really hard to make a computer. Comprehending how a CPU processes rudimentary electrical pulses to transform them into complex instruction sets is mind-bending, at least to me. I've sat down and thought about it critically. I've set up a few experiments, too. There's one you can do with dominoes, believe it or not, that can somewhat help you design a logic circuit. There's a Turing Machine you can build with Magic The Gathering cards. And an electronics kit that'll help you build an 8bit CPU. But even with all of those experiments, the open RISC-V CPU still eludes my comprehension. And just to be clear: back in 2008 or so, I was hired to stress test a RISC CPU to determine whether it was efficient at rendering massive amounts of video. I designed tests in an attempt to prove that a RISC CPU could not out-perform the latest Intel Core2duo, and could not achieve the goal (RISC is better, what can I say?) So my affinity for RISC is far from just a passing interest. But I can't build a RISC-V or even really explain how a CPU works. For that, I understand that there are experts. These aren't just people I call experts because they're labeled that way on their shirt pocket. They're experts because they're building the RISC-V, and it works. I met some of them back at OSS Con in 2019. I recognize their expertise, because they're proving their knowledge. Let's say I approached the RISC-V booth with the preconception that x86 was superior. After all, why would most consumer computers be running x86 if it weren't the best? I might be skeptical if I were told that RISC-V is superior for some tasks. Could they have ulterior motives? Could they have been paid off by Big Silicon to lie about RISC's performance in order to hurt x86's marketshare? Sure, it could happen. And that skepticism is important. It's arguably part of the scientific process. Look at the results of an experiment, replicate the input and ensure that the output is reliably the same. But you can't be sure until you've duplicated the experiments that make the claim in the first place. Unfortunately, this often requires some pretty controlled environments, and possibly some pretty high end equipment. The bottom line is that I'm never going to get around to doing that, I'm never going to have access to those resources, and I'm never going to have the understanding I'd need to comprehend all the potential variables involved. In short, I just don't have the expertise. But I'm willing to trust the expertise of a lot of people from all over the world working on this project. I'm going to trust that because they all agree on similar findings, that what they're saying about the design and architecture of their CPU, that there's a high likelihood that their findings are correct. The same goes, as it turns out, for biological sciences. No matter how many one-off experiments discover that cigarette smoking is beneficial to your health, the wider scientific consensus is that it's harmful. No matter how man "free-thinkers" on the Internet discover that Covid-19 is actually no worse than the common cold, the worldwide scientific community asserts that it's actually harmful, and medical staffs across the globe assert that increased cases of Covid-19 cause bed and healthcare shortages for everyone else. Somebody online may assert that it's an impossibly unified globe-spanning political plot, but that relies on a bunch of untest-able opinions and interpretations of reality that fall well outside any scientific framework. It seems to me that this line of speculation makes about as much sense as asking whether your computer can really still add numbers accurately. Couldn't it occasionally be lying to you? The device you're using to listen to my voice right now not to scramble what I'm saying and accurately play what I recorded in the first place is based on the same scientific principles used by those in biological sciences. We're feeding data into functions, whether the function is written in code, forged in silicon, or written on paper as a math formula, and we're observing the results. When every expert in their field, across the entire globe, agrees on the output, I think we do too. It's either that, or we'd better all go build our own 8bit circuits out of chickens and batteries and just start to rebuild. So did the PDF I uploaded as part of the Scribus episode no longer contain a payload if the listener who downloaded it wasn't aware that the payload existed? Obviously not. If the listener lacked the foresight or expertise to investigate the PDF for a hidden file, then they could have posted an episode of their own about how my PDF was completely normal. They'd have been confident in their findings. But you and I know that whatever experiments they might have used to come to the conclusion that Klaatu was NOT a liar was, in the end, insufficient. The payload did exist, but it was just outside this imaginary listener's detection or comprehension. Critical thinking is important. But at the same time, the scientific framework requires more than just critical thinking, just as building a RISC-V CPU requires more than just being a fan of reduced instruction sets. And solving the Covid-19 crisis takes a lot more than just critical thinking and a couple of backyard "experiments." We're not in the Dark Ages any more, folks. Get vaccinated. Stay safe, and I'll talk to you next time.
On today's episode, Courtney shares how she got into Product and how her love for discovery started in her career before she got into Product. We talked a lot about diverse inputs, and we talked about what good discovery is NOT. Enjoy! --- Send in a voice message: https://anchor.fm/productmanagementlessons/message Support this podcast: https://anchor.fm/productmanagementlessons/support
Listened to an episode of Honey Bee Obscura (their episode 41) on fall feeding and wanted to share observations it brought to mind and other ideas about feeding options with you all. It's that time of year! This episode of BFAF released on 06 OCT to Patrons and to the public on 10 OCT. Patrons, remember you have your own audio RSS feed for all the podcasts, plus your early releases and bonus episodes. If you log into Patreon and navigate to your membership tab, your private RSS feed is show there and can be copy/pasted into your favorite podcast app! Show notes and links mentioned in this episode are available to everyone here: https://www.patreon.com/posts/57083467 -- Please become a "Friend of the Podcast" on Patreon and join the folks who make the podcasts possible! In addition to huge gratitude, you get: • BONUS podcasts and early access episodes • Access to Patreon blog posts including tips and videos • Special Q&A posts to ask me questions about YOUR bees • Input on the podcast topics • Shout-outs on the show because I appreciate you! If you can support the show with $1 a month or more, please sign up today: https://www.patreon.com/fiveapple -- About Beekeeping at Five Apple Farm: Leigh keeps bees at 3000' in the Blue Ridge Mountains of North Carolina. She cares for around a 'beekeeper's dozen' of hives in a rural, high Appalachian climate. Colonies are managed for bee health with active selection for vigor, genetic diversity and disease resistance, but without chemical treatments. The apiary is self-sustaining (not needing to buy/catch replacement bees since 2010) and produces honey and nucs most every year.
Raspberries, ellagic acid reveal benefits in two studies Oregon State University, October 1, 2021. Articles that appeared recently in the Journal of Berry Research report that raspberries and compounds present in the fruit could help support healthy body mass and motor function, including balance, coordination and strength. In one study, Neil Shay and colleagues at Oregon State University fed mice a high fat, high sugar diet plus one of the following: raspberry juice concentrate, raspberry puree concentrate, raspberry fruit powder, raspberry seed extract, ellagic acid (a polyphenol that occurs in a relatively high amount in raspberries), raspberry ketone, or a combination of raspberry ketone and ellagic acid. Additional groups of animals received a high fat, high sugar diet alone or a low fat diet. While mice that received the high fat and sugar diet alone experienced a significant increase in body mass, the addition of raspberry juice concentrate, raspberry puree concentrate or ellagic acid plus raspberry ketone helped prevent this effect. Of note, mice that received raspberry juice concentrate experienced gains similar to those of animals given a low fat diet. "We hope that the findings from this study can help guide the design of future clinical trials," Dr Shay stated. In another study, Barbara Shukitt-Hale, PhD, and her associates at Tufts University's Human Nutrition Research Center on Aging gave 19 month old rats a control diet or a diet enhanced with raspberry extract for 11 weeks. Psychomotor behavior was assessed during week 7 and cognitive testing was conducted during weeks 9-10. Animals that received raspberry performed better on psychomotor coordination and balance, and had better muscle tone, strength and stamina than those that received a control diet. "These results may have important implications for healthy aging," stated Dr Shukitt-Hale. "While further research in humans is necessary, animal model studies are helpful in identifying deficits associated with normal aging." Massage doesn't just make muscles feel better, it makes them heal faster and stronger Harvard University, October 6, 2021 Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes." Using a custom-designed robotic system to deliver consistent and tunable compressive forces to mice's leg muscles, the team found that this mechanical loading (ML) rapidly clears immune cells called neutrophils out of severely injured muscle tissue. This process also removed inflammatory cytokinesreleased by neutrophils from the muscles, enhancing the process of muscle fiber regeneration. The research is published in Science Translational Medicine. "Lots of people have been trying to study the beneficial effects of massage and other mechanotherapies on the body, but up to this point it hadn't been done in a systematic, reproducible way. Our work shows a very clear connection between mechanical stimulation and immune function. This has promise for regenerating a wide variety of tissues including bone, tendon, hair, and skin, and can also be used in patients with diseases that prevent the use of drug-based interventions," said first author Bo Ri Seo, Ph.D., who is a Postdoctoral Fellow in the lab of Core Faculty member Dave Mooney, Ph.D. at the Wyss Institute and SEAS. Seo and her coauthors started exploring the effects of mechanotherapy on injured tissues in mice several years ago, and found that it doubled the rate of muscle regeneration and reduced tissue scarring over the course of two weeks. Excited by the idea that mechanical stimulation alone can foster regeneration and enhance muscle function, the team decided to probe more deeply into exactly how that process worked in the body, and to figure out what parameters would maximize healing. They teamed up with soft robotics experts in the Harvard Biodesign Lab, led by Wyss Associate Faculty member Conor Walsh, Ph.D., to create a small device that used sensors and actuators to monitor and control the force applied to the limb of a mouse. " The device we created allows us to precisely control parameters like the amount and frequency of force applied, enabling a much more systematic approach to understanding tissue healing than would be possible with a manual approach," said co-second author Christopher Payne, Ph.D., a former Postdoctoral Fellow at the Wyss Institute and the Harvard Biodesign Lab who is now a Robotics Engineer at Viam, Inc. Once the device was ready, the team experimented with applying force to mice's leg muscles via a soft silicone tip and used ultrasound to get a look at what happened to the tissue in response. They observed that the muscles experienced a strain of between 10-40%, confirming that the tissues were experiencing mechanical force. They also used those ultrasound imaging data to develop and validate a computational model that could predict the amount of tissue strain under different loading forces. They then applied consistent, repeated force to injured muscles for 14 days. While both treated and untreated muscles displayed a reduction in the amount of damaged muscle fibers, the reduction was more pronounced and the cross-sectional area of the fibers was larger in the treated muscle, indicating that treatment had led to greater repair and strength recovery. The greater the force applied during treatment, the stronger the injured muscles became, confirming that mechanotherapy improves muscle recovery after injury. But how? Evicting neutrophils to enhance regeneration To answer that question, the scientists performed a detailed biological assessment, analyzing a wide range of inflammation-related factors called cytokines and chemokines in untreated vs. treated muscles. A subset of cytokines was dramatically lower in treated muscles after three days of mechanotherapy, and these cytokines are associated with the movement of immune cells called neutrophils, which play many roles in the inflammation process. Treated muscles also had fewer neutrophils in their tissue than untreated muscles, suggesting that the reduction in cytokines that attract them had caused the decrease in neutrophil infiltration. The team had a hunch that the force applied to the muscle by the mechanotherapy effectively squeezed the neutrophils and cytokines out of the injured tissue. They confirmed this theory by injecting fluorescent molecules into the muscles and observing that the movement of the molecules was more significant with force application, supporting the idea that it helped to flush out the muscle tissue. To pick apart what effect the neutrophils and their associated cytokines have on regenerating muscle fibers, the scientists performed in vitro studies in which they grew muscle progenitor cells (MPCs) in a medium in which neutrophils had previously been grown. They found that the number of MPCs increased, but the rate at which they differentiated (developed into other cell types) decreased, suggesting that neutrophil-secreted factors stimulate the growth of muscle cells, but the prolonged presence of those factors impairs the production of new muscle fibers. "Neutrophils are known to kill and clear out pathogens and damaged tissue, but in this study we identified their direct impacts on muscle progenitor cell behaviors," said co-second author Stephanie McNamara, a former Post-Graduate Fellow at the Wyss Institute who is now an M.D.-Ph.D. student at Harvard Medical School (HMS). "While the inflammatory response is important for regeneration in the initial stages of healing, it is equally important that inflammation is quickly resolved to enable the regenerative processes to run its full course." Seo and her colleagues then turned back to their in vivo model and analyzed the types of muscle fibers in the treated vs. untreated mice 14 days after injury. They found that type IIX fibers were prevalent in healthy muscle and treated muscle, but untreated injured muscle contained smaller numbers of type IIX fibers and increased numbers of type IIA fibers. This difference explained the enlarged fiber size and greater force production of treated muscles, as IIX fibers produce more force than IIA fibers. Finally, the team homed in on the optimal amount of time for neutrophil presence in injured muscle by depleting neutrophils in the mice on the third day after injury. The treated mice's muscles showed larger fiber size and greater strength recovery than those in untreated mice, confirming that while neutrophils are necessary in the earliest stages of injury recovery, getting them out of the injury site early leads to improved muscle regeneration. "These findings are remarkable because they indicate that we can influence the function of the body's immune system in a drug-free, non-invasive way," said Walsh, who is also the Paul A. Maeder Professor of Engineering and Applied Science at SEAS and whose group is experienced in developing wearable technology for diagnosing and treating disease. "This provides great motivation for the development of external, mechanical interventions to help accelerate and improve muscle and tissue healing that have the potential to be rapidly translated to the clinic." The team is continuing to investigate this line of research with multiple projects in the lab. They plan to validate this mechanotherpeutic approach in larger animals, with the goal of being able to test its efficacy on humans. They also hope to test it on different types of injuries, age-related muscle loss, and muscle performance enhancement. "The fields of mechanotherapy and immunotherapy rarely interact with each other, but this work is a testament to how crucial it is to consider both physical and biological elements when studying and working to improve human health," said Mooney, who is the corresponding author of the paper and the Robert P. Pinkas Family Professor of Bioengineering at SEAS. "The idea that mechanics influence cell and tissue function was ridiculed until the last few decades, and while scientists have made great strides in establishing acceptance of this fact, we still know very little about how that process actually works at the organ level. This research has revealed a previously unknown type of interplay between mechanobiology and immunology that is critical for muscle tissue healing, in addition to describing a new form of mechanotherapy that potentially could be as potent as chemical or gene therapies, but much simpler and less invasive," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at (HMS) and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS. Vitamin E could help protect older men from pneumonia University of Helsinki (Finland), October 7 2021. An article that appeared in Clinical Interventions in Aging reported a protective role for vitamin E against pneumonia in older men. For the current investigation, Dr Harri Hemilä of the University of Helsinki, Finland analyzed data from the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study conducted in Finland. The trial included 29,133 men between the ages of 50 to 69 years who smoked at least five cigarettes daily upon enrollment. Participants received alpha tocopherol (vitamin E), beta carotene, both supplements, or a placebo for five to eight years. The current study was limited to 7,469 ATBC participants who started smoking at age 21 or older. Among this group, supplementation with vitamin E was associated with a 35% lower risk of developing pneumonia in comparison with those who did not receive the vitamin. Light smokers who engaged in leisure time exercise had a 69% lower risk compared with unsupplemented members of this subgroup. The risk in this subgroup of developing pneumonia by age 74 was 12.9%. Among the one-third of the current study's population who quit smoking for a median period of two years, there was a 72% lower risk of pneumonia in association with vitamin E supplementation. In this group, exercisers who received vitamin E experienced an 81% lower pneumonia risk. Dr Hemilä observed that the benefit for vitamin E in this study was strongest for older subjects—a group at higher risk of pneumonia. "The current analysis of individual-level data suggests that trials on vitamin E and pneumonia on nonsmoking elderly males are warranted," he concluded. Toxic fatty acids to blame for brain cell death after injury New York University, October 7, 2021 Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say. Previous research has pointed to astrocytes—a star-shaped glial cell of the central nervous system—as the culprits behind cell death seen in Parkinson's disease and dementia, among other neurodegenerative diseases. While many experts believed that these cells released a neuron-killing molecule to "clear away" damaged brain cells, the identity of this toxin has until now remained a mystery. Led by researchers at NYU Grossman School of Medicine, the new investigation provides what they say is the first evidence that tissue damage prompts astrocytes to produce two kinds of fats, long-chain saturated free fatty acids and phosphatidylcholines. These fats then trigger cell death in damaged neurons, the electrically active cells that send messages throughout nerve tissue. Publishing Oct. 6 in the journal Nature, the study also showed that when researchers blocked fatty acid formation in mice, 75 percent of neurons survived compared with 10 percent when the fatty acids were allowed to form. The researchers' earlier work showed that brain cells continued to function when shielded from astrocyte attacks. "Our findings show that the toxic fatty acids produced by astrocytes play a critical role in brain cell death and provide a promising new target for treating, and perhaps even preventing, many neurodegenerative diseases," says study co-senior author Shane Liddelow, Ph.D. Liddelow, an assistant professor in the Department of Neuroscience and Physiology at NYU Langone Health, adds that targeting these fats instead of the cells that produce them may be a safer approach to treating neurodegenerative diseasesbecause astrocytes feed nerve cells and clear away their waste. Stopping them from working altogether could interfere with healthy brain function. Although it remains unclear why astrocytes produce these toxins, it is possible they evolved to destroy damaged cells before they can harm their neighbors, says Liddelow. He notes that while healthy cells are not harmed by the toxins, neurons become susceptible to the damaging effects when they are injured, mutated, or infected by prions, the contagious, misfolded proteins that play a major role in mad cow disease and similar illnesses. Perhaps in chronic diseases like dementia, this otherwise helpful process goes off track and becomes a problem, the study authors say. For the investigation, researchers analyzed the molecules released by astrocytes collected from rodents. They also genetically engineered some groups of mice to prevent the normal production of the toxic fats and looked to see whether neuron death occurred after an acute injury. "Our results provide what is likely the most detailed molecular map to date of how tissue damage leads to brain cell death, enabling researchers to better understand why neurons die in all kinds of diseases," says Liddelow, also an assistant professor in the Department of Ophthalmology at NYU Langone. Liddelow cautions that while the findings are promising, the genetic techniques used to block the enzyme that produces toxic fatty acids in mice are not ready for use in humans. As a result, the researchers next plan is to explore safe and effective ways to interfere with the release of the toxins in human patients. Liddelow and his colleagues had previously shown these neurotoxic astrocytes in the brains of patients with Parkinson's, Huntington's disease, and multiple sclerosis, among other diseases. Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 3, 2021 In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite -- known as NAD+ -- can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline. These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people. The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®. The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner's lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses. "This trial shows that oral NR safely boosts human NAD+ metabolism," Brenner says. "We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely." The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy. Prior to the formal clinical trial, Brenner conducted a pilot human study -- on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with UI's institutional review board, he conducted an experiment in which he took 1 gram of NR once a day for seven days, and his team analyzed blood and urine samples using mass spectrometry. The experiment showed that Brenner's blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR. The biggest surprise from his metabolomic analysis was an increase in a metabolite called NAAD, which was multiplied by 45 times, from trace levels to amounts in the micromolar range that were easily detectable. "While this was unexpected, I thought it might be useful," Brenner says. "NAD+ is an abundant metabolite and it is sometimes hard to see the needle move on levels of abundant metabolites. But when you can look at a low-abundance metabolite that goes from undetectable to easily detectable, there is a great signal to noise ratio, meaning that NAAD levels could be a useful biomarker for tracking increases in NAD+ in human trials." Brenner notes this was a case of bidirectional translational science; having learned something from the initial human experiment, his team was able to return to laboratory mice to explore the unexpected NAAD finding in more detail. Brenner's mouse study showed that NAAD is formed from NR and confirmed that NAAD levels are a strong biomarker for increased NAD+ metabolism. The experiments also revealed more detail about NAD+ metabolic pathways. In particular, the researchers compared the ability of all three NAD+ precursor vitamins -- NR, niacin, and nicotinamide -- to boost NAD+ metabolism and stimulate the activity of certain enzymes, which have been linked to longevity and healthbenefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide. The information from the mouse study subsequently helped Brenner's team design the formal clinical trial. In addition to showing that NR boosts NAD+ in humans without adverse effects, the trial confirmed that NAAD is a highly sensitive biomarker of NAD+ supplementation in people. "Now that we have demonstrated safety in this small clinical trial, we are in a position to find out if the health benefits that we have seen in animals can be reproduced in people," says Brenner, who also is co-director of the Obesity Research and Education Initiative, professor of internal medicine, and a member of the Fraternal Order of Eagles Diabetes Research Center at the UI. Protecting the ozone layer is delivering vast health benefits Montreal Protocol will spare Americans from 443 million skin cancer cases National Center for Atmospheric Research, October 7, 2021 An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team, by scientists at the National Center for Atmospheric Research (NCAR), ICF Consulting, and U.S. Environmental Protection Agency (EPA), focused on the far-reaching impacts of a landmark 1987 treaty known as the Montreal Protocol and later amendments that substantially strengthened it. The agreement phased out the use of chemicals such as chlorofluorocarbons (CFCs) that destroy ozone in the stratosphere. Stratospheric ozone shields the planet from harmful levels of the Sun's ultraviolet (UV) radiation, protecting life on Earth. To measure the long-term effects of the Montreal Protocol, the scientists developed a computer modeling approach that enabled them to look to both the past and the future by simulating the treaty's impact on Americans born between 1890 and 2100. The modeling revealed the treaty's effect on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits. In addition to the number of skin cancer and cataract cases that were avoided, the study also showed that the treaty, as most recently amended, will prevent approximately 2.3 million skin cancer deaths in the U.S. “It's very encouraging,” said NCAR scientist Julia Lee-Taylor, a co-author of the study. “It shows that, given the will, the nations of the world can come together to solve global environmental problems.” The study, funded by the EPA, was published in ACS Earth and Space Chemistry. NCAR is sponsored by the National Science Foundation. Mounting concerns over the ozone layer Scientists in the 1970s began highlighting the threat to the ozone layer when they found that CFCs, used as refrigerants and in other applications, release chlorine atoms in the stratosphere that set off chemical reactions that destroy ozone. Concerns mounted the following decade with the discovery of an Antarctic ozone hole. The loss of stratospheric ozone would be catastrophic, as high levels of UV radiation have been linked to certain types of skin cancer, cataracts, and immunological disorders. The ozone layer also protects terrestrial and aquatic ecosystems, as well as agriculture. Policy makers responded to the threat with the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, in which nations agreed to curtail the use of certain ozone-destroying substances. Subsequent amendments strengthened the treaty by expanding the list of ozone-destroying substances (such as halons and hydrochlorofluorocarbons, or HCFCs) and accelerating the timeline for phasing out their use. The amendments were based on Input from the scientific community, including a number of NCAR scientists, that were summarized in quadrennial Ozone Assessment reports. To quantify the impacts of the treaty, the research team built a model known as the Atmospheric and Health Effects Framework. This model, which draws on various data sources about ozone, public health, and population demographics, consists of five computational steps. These simulate past and future emissions of ozone-destroying substances, the impacts of those substances on stratospheric ozone, the resulting changes in ground-level UV radiation, the U.S. population's exposure to UV radiation, and the incidence and mortality of health effects resulting from the exposure. The results showed UV radiation levels returning to 1980 levels by the mid-2040s under the amended treaty. In contrast, UV levels would have continued to increase throughout this century if the treaty had not been amended, and they would have soared far higher without any treaty at all. Even with the amendments, the simulations show excess cases of cataracts and various types of skin cancer beginning to occur with the onset of ozone depletion and peaking decades later as the population exposed to the highest UV levels ages. Those born between 1900 and 2040 experience heightened cases of skin cancer and cataracts, with the worst health outcomes affecting those born between about 1950 and 2000. However, the health impacts would have been far more severe without the treaty, with cases of skin cancer and cataracts rising at an increasingly rapid rate through the century. “We peeled away from disaster,” Lee-Taylor said. “What is eye popping is what would have happened by the end of this century if not for the Montreal Protocol. By 2080, the amount of UV has tripled. After that, our calculations for the health impacts start to break down because we're getting so far into conditions that have never been seen before.” The research team also found that more than half the treaty's health benefits could be traced to the later amendments rather than the original 1987 Montreal Protocol. Overall, the treaty prevented more than 99% of potential health impacts that would have otherwise occurred from ozone destruction. This showed the importance of the treaty's flexibility in adjusting to evolving scientific knowledge, the authors said. The researchers focused on the U.S. because of ready access to health data and population projections. Lee-Taylor said that the specific health outcomes in other countries may vary, but the overall trends would be similar. “The treaty had broad global benefits,” she said. What is Boron? The trace mineral boron provides profound anti-cancer effects, in addition to maintaining stronger bones. Life Extension, September 2021 Boron is a trace mineral found in the earth's crust and in water. Its importance in human health has been underestimated. Boron has been shown to have actions against specific types of malignancies, such as: Cervical cancer: The country Turkey has an extremely low incidence of cervical cancer, and scientists partially attribute this to its boron-rich soil.1 When comparing women who live in boron-rich regions versus boron-poor regions of Turkey, not a single woman living in the boron-rich regions had any indication of cervical cancer.2(The mean dietary intake of boron for women in this group was 8.41 mg/day.) Boron interferes with the life cycle of the human papillomavirus (HPV), which is a contributing factor in approximately 95% of all cervical cancers.1 Considering that HPV viruses are increasingly implicated in head and neck cancers,3,4 supplementation with this ultra-low-cost mineral could have significant benefits in protecting against this malignancy that is increasing in prevalence. Lung cancer: A study conducted at the University of Texas MD Anderson Cancer Center between 1995 and 2005 found that increased boron intake was associated with a lower risk of lung cancer in postmenopausal women who were taking hormone replacement therapy. Prostate cancer: Studies point to boron's ability to inhibit the growth and spread of prostate cancer cells. In one study, when mice were exposed to boric acid, their tumors shrank by as much as 38%.6 One analysis found that increased dietary boron intake was associated with a decreased risk of prostate cancer.7 Several human and animal studies have confirmed the important connection between boron and bone health. Boron prevents calcium loss,8 while also alleviating the bone problems associated with magnesium and vitamin D deficiency.9 All of these nutrients help maintain bone density. A study in female rats revealed the harmful effects a deficiency in boron has on bones, including:10 Decreased bone volume fraction, a measure of bone strength, Decreased thickness of the bone's spongy inner layer, and Decreased maximum force needed to break the femur. And in a study of post-menopausal women, supplementation with3 mg of boron per day prevented calcium loss and bone demineralization by reducing urinary excretion of both calcium and magnesium.8 In addition to its bone and anti-cancer benefits, there are nine additional reasons boron is an important trace mineral vital for health and longevity. It has been shown to:1 Greatly improve wound healing, Beneficially impact the body's use of estrogen, testosterone, and vitamin D, Boost magnesium absorption, Reduce levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α), Raise levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, Protect against pesticide-induced oxidative stress and heavy-metal toxicity, Improve the brain's electrical activity, which may explain its benefits for cognitive performance, and short-term memory in the elderly, Influence the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+), and Potentially help ameliorate the adverse effects of traditional chemotherapeutic agents. Because the amount of boron varies in the soil, based on geographical location, obtaining enough boron through diet alone can be difficult. Supplementing with low-cost boron is an effective way to maintain adequate levels of this overlooked micronutrient.
Doing the first look-back of the 2021 season at the things that have gone well so far! Thank you Patrons and Listeners! I appreciate each and every one of you. kind regards, Leigh (recorded 21SEP21 - released to Patrons on 26SEP21) -- Please become a "Friend of the Podcast" on Patreon and join the folks who make the podcasts possible! In addition to huge gratitude, you get: • BONUS podcast or early access episode every month! • Access to Patreon • blog posts including "Tip of the Week" • Special Q&A posts to ask me questions about YOUR bees • Input on the podcast topics • Shout-outs on the show because I appreciate you! You can support this podcast you are able to share $1 or up a month, please sign up today: https://www.patreon.com/fiveapple -- About Beekeeping at Five Apple Farm: Leigh keeps bees at 3000' in the Blue Ridge Mountains of North Carolina with around a dozen-ish stands. Hives are managed for bee health with active selection for vigor, genetic diversity and disease resistance. The apiary is self-sustaining (not needing to buy/catch replacement bees since 2010) and produces honey and nucs most every year.
What if I told you the way your brain is wired may be getting in your way of having an extraordinary marriage? You see, there are 3 phases of thinking: 1. Input - how we take in the information. 2. Elaboration - how we process the information. 3. Output - how we tell the world what we know. In each phase there are are many parts - 28 in total. These 28 parts are called Cognitive Functions and when one of them are weak it effects everything else in your life - including your marriage. From this episode on, every Tuesday & Thursday we'll being going to the cognitive functions so you can rewire our brain and have that extraordinary marriage with more ease. To learn more how you can work with ST and rewire your brain head over to www.lifepixuniversity.com/yourbrainrewired
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