Podcasts about Krogan

Today, we dance the Krogan dance, take down some mob-guys, advocate for our dreams, and wonder what's going on under that helmet! Show Notes Super NPC Radio – Patreon - Discord-  Bluesky – Instagram – Twitch Jeremy Schmidt: Video Games: a Comedy Show - BlueSky Conner McCabe – Call Me By Your Game podcast - Bluesky - Twitch July Diaz: Bluesky Nick Costanza: Bluesky Mikey McCollor: YouTube Roxy Polk: BlueSky - Twitch

Christian plays Mass Effect for the first time and is in love with a Krogan. Bobby successfully finds a replacement for Stardew Valley, hold the ghost fox. Emilio plays a top-down Battle Royale and lives up to his nickname "Mr. Chickideedeedee Dinner". TOPICS Travellers Rest, Supervive, Mass Effect™ Legendary Edition, Covenant, Your Tree, Steel Series Arctis Nova Pro TIMESTAMPS Intro - 00:00 Pinging It - 3:05 Travellers Rest - 9:06 Supervive - 18:39 Mass Effect - 29:43 Covenant - 42:10 Your Tree - 52:28 Steel Series Arctis Nova Pro - 55:00 Listener Questions - 1:02:30 For more content, check out dlgaming.net! Learn more about your ad choices. Visit megaphone.fm/adchoices

https://www.patreon.com/isyanderandkoda You already know how to please the Machine Gods at this point so thank you so much. And make your voices heard for which faction you would like to see next! -Isyander Everything below is for the omnissiah. But like, you can read it if you want. Just a synopsis of the video you're watching.In this video, we take you on an epic journey through the entire timeline of the Mass Effect universe, spanning from ancient civilizations to the dramatic events of Commander Shepard's battle against the Reapers. Whether you're a seasoned Mass Effect fan or new to the series, this video provides a comprehensive deep dive into the major events that shaped this beloved sci-fi universe.Join us as we explore the origins of the Milky Way's most powerful species, from the ancient Leviathans—who once dominated the galaxy before creating the Reapers—to the rise of the Protheans and their tragic fall during the Reaper invasion. Learn how humanity evolved alongside the other species of the galaxy, from the neolithic revolution to humanity's first steps into space, culminating in the pivotal discovery of the Prothean relics on Mars in 2148 that unlocked the secrets of Mass Effect technology.We cover the major milestones in Mass Effect history, including the First Contact War between humanity and the Turians, the formation of the Systems Alliance, and the rise of humanity as a key player in the galactic community. Discover the powerful roles played by other species such as the Asari, Turians, Salarians, Krogan, and more as they work together—and sometimes against each other—to survive in a universe constantly under threat.Of course, the timeline would be incomplete without the Reapers. We dive into their terrifying cycle of harvesting galactic civilizations every 50,000 years and how their arrival in the Mass Effect trilogy changed everything. From Commander Shepard's legendary quest to stop Sovereign, Saren, and the Collectors to the final battle against the Reapers in Mass Effect 3, we break down the crucial events that shaped the fate of the galaxy.This comprehensive timeline also covers key figures like Jon Grissom, Captain Anderson, and Commander Shepard, along with important events such as the Skyllian Blitz, the discovery of biotics, and the formation of Cerberus. We also explore how the galaxy evolved after the first game's events, including the mystery of the missing colonies and Shepard's resurrection by the Illusive Man in Mass Effect 2.Get ready to immerse yourself in the rich lore and history of Mass Effect, from the dawn of galactic civilizations to the Reapers' apocalyptic invasion. Whether you're looking to refresh your knowledge before replaying the games or discovering new details about this incredible universe, this video will give you the ultimate timeline of Mass Effect.———TAGS Mass Effect timeline, Mass Effect history, Reapers Mass Effect, Commander Shepard, Systems Alliance, First Contact War, Protheans, Citadel Council, Mass Effect lore, Mass Effect universe, Mass Effect explained, Reaper invasion, Mass Effect 3 timeline, Cerberus, Mass Effect biotics, Mass Effect races, Mass Effect Reapers explained, Leviathans Mass Effect, Prothean technology, Geth rebellion, Mass Effect timeline video, Mass Effect timeline breakdown, Mass Effect 3, Mass Effect 2, SSV Normandy, Illusive Man, Mass Effect story, Mass Effect plot explained, Mass Effect characters, Mass Effect galaxy, Mass Effect factions, Mass Effect relays, Mass Effect lore deep dive, Sci-fi game timeline, Space RPG lore, Bioware Mass Effect series. ————————————Opinions expressed in this video are solely those of Isyander & Koda and in no way reflect the views or opinions of EA, or Bioware StudioSupport the show

Episode 1 (Week ending December 8, 2023): Nevan Krogan (UCSF) mapping autism pathways; Nvidia's latest AI partnership; CAR-T regulations; epigenome editing; mRNA therapeutics.References to the GEN stories, media and other items discussed in this episode of Touching Base:· Autism's Molecular Mechanisms Uncovered through Protein-Protein Interaction NetworkBy Julianna Lemieux, GEN, December 5, 2023.· Rhapsody in B: Tune Therapeutics Presents Data for Hepatitis B Epigenetic SilencerBy Jonathan Grinstein, GEN Edge, December 6, 2023.· Nvidia Looks to Genentech for its Next Leap in AI Drug DiscoveryBy Alex Philippidis, GEN Edge, November 28, 2023.· StockWatch: CAR-T Shares Mostly Flat as FDA Probes Risk of New CancersBy Alex Philippidis, GEN, December 1, 2023· Perfect Pitch: Genome Editing Pioneer Fyodor Urnov on Commercializing CRISPR Therapies and Epigenomic Tuning {VIDEO}GEN Edge, August 30, 2023· Press release: John Crowley appointed President & CEO of BIOBiotechnology Innovation Organization· BIO CEO Rachel King Outlines Industry's Challenges on “Close to the Edge”GEN multimedia, April 26, 2023 · The First CRISPR Drug: Vertex Pharmaceuticals' Casgevy Wins U.K. Approval for Sickle Cell DiseaseGEN, November 16, 2023 Hosted on Acast. See acast.com/privacy for more information.

The crew continue to maneuver through the Blood Moon Masquerade. With the summons to dinner, will their lies begin to unravel or can they achieve an early victory?

Session 2: Bring your Krick to Work Day Part 2 The Mission continues, but with the only shuttle down on the stormy world of Novolori, and communication acting up for the ground team, what's a Krogan left on the ship to do? The decisions may surprise you! Tonight on WOLFPACK: Jackass Edition! Cast: Chris - GM Aaron - Theodore Ronin Hunter (Human Vanguard) Josh - Hilo'Vael Vas Wolfpack Nar Colepsi (Quarian Machinist)/Lia'dana Vas Wolfpack Nar Nia (Quarian Biotic) Seb - Korlus Runt (Krogan Battlemaster) (1.5 yrs old, give or take 606 years, looks “112 yrs”) Dave - Olka Ibn'taaj (Batarian Infiltrator)/Maerk Mamu (Volus Sentinel) Adam - Krick (Vorcha Hunter) Chris - Urdnot Wrex (Krogan Battlemaster) Marc - Tom Johnson (Human Soldier) Musical Credits:  NewsSting by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4124-newssting  License: https://filmmusic.io/standard-license

When the decision needs to be made, who do you pick? In this weeks episode of Mass Effect, the guys tackle Saren head on and attempt to disrupt his plans to breed a Krogan army! Massive secrets are learnt about the Reapers, their origin, and even Saren's motives. At the end of it all, a tough decision must be made ... Find all of our socials, our Patreon, as well as our discord server here! https://linktr.ee/PlayAlongPodcast Episodes of this podcast go up every Tuesday at 9 am PST Intro and outro music is done by https://boqeh.bandcamp.com Music Break 1 - Skyway Weigh Station --- Send in a voice message: https://podcasters.spotify.com/pod/show/playalongpodcast/message

Everything on Tuchanka is normal and fine and de[THIS PORTION OF THE SHOW NOTES HAVE BEEN REPOSSESSED BY ORDER OF THE ESTATE OF FREDERICK JAMES PRINZE JUNIOR]//Follow us!The show - https://asynchpod.tumblr.com/Kim - https://ohkimmies.tumblr.com/ // https://twitter.com/ohkimmiesAJ - https://notajfillari.tumblr.com/ // https://theaether.space/@aj (Mastodon)//Thanks to _amaranthine for our theme music! Listen to his other stuff on bandcamp! - https://amaranthine.bandcamp.com/Follow him on Twitter! - https://twitter.com/_amrnthneThanks to Scout for making our art! Check out her ko-fi! - https://ko-fi.com/humblegoatFollow her on Twitter! - https://twitter.com/humblegoat//Produced & edited by AJ Fillarihttps://theworstgarbage.online/// (00:00) - Intro and moving woes (04:03) - Cozy up, it's time for Bullshit (12:38) - Normandy (12:51) - Normandy // James (15:00) - Normandy // Steve (17:37) - Normandy // Chakwas & Adams (18:29) - Normandy // Liara (24:36) - Normandy // Garrus (25:23) - Normandy // Joker + EDI (27:45) - Tuchanka: Turian Platoon (39:02) - Tuchanka: Turian Platoon // Normandy (45:59) - Normandy // Anderson (47:19) - Normandy // Liara's time capsule (48:50) - Normandy // Javik (55:27) - Attican Traverse: Krogan Team (01:14:13) - Normandy // Javik (01:15:59) - Normandy // Garrus (01:16:34) - Normandy // Mordin (01:20:21) - Normandy // Joker + EDI (01:21:24) - Normandy // Adams (01:21:35) - Normandy // James + Steve (01:22:28) - A Funny Thing Happened on the Way to Tuchanka (01:27:42) - Our trials and tribulations have come to an end (01:27:58) - Thanks for listening!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.26.530133v1?rss=1 Authors: Memisoglu, G., Bohn, S., Krogan, N., Haber, J. E., Ruthenburg, A. J. Abstract: When faced with a DNA double strand break, cells activate an elaborate signaling cascade called the DNA damage response to protect genomic integrity. To identify novel factors that modulate the DNA damage response to DNA double strand breaks, we performed an epistatic miniarray profile analysis of Mec1 and Rad53, two essential kinases that coordinate the DNA damage response in budding yeast. Through this analysis, we discovered a genetic interaction between the kinase module (CKM) of the Mediator of transcription and Rad53. We find that all four subunits of the CKM, as well as CKM's kinase activity are critical for cell cycle re-entry following a DNA break, whereas the core Mediator subunits are dispensable. Notably, CKM mutants do not impair DNA repair by homologous recombination or confer sensitivity to DNA damaging reagents, suggesting that CKM specifically impinges on DNA damage signaling. In support of this, we find that Rad53 and CKM physically interact in response to DNA damage. Following the induction of a DNA break, CKM is a critical regulator of global transcription inhibition. In addition to this global effect, we illustrate that CKM functions locally at DNA breaks together with the core Mediator. In the absence of catalytically active CKM, the CKM-Mediator complexes at DNA breaks are replaced by RNAPII. Taken together, our results reveal a previously uncharacterized role for CKM in the DNA damage response. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Square Roots - Episode 350 Shepherd takes some selfie hints from the 21st century in this action-packed chunker of Mass Effect 3! There's meeting a 50,000 year old Protheon, hot gossip with the lady Krogan, and seeing Jack's clothing journey. Also: - Your Favourite Mary Kate & Ashley Songs - The Pegger - New Game Plus Elementary School - Her Two Big Front Mounted Processors - Ensign Pringles Saves The Day - Bring Your Bits! Whatever! This Week: Extract Lady Krogan, Javik, Biotic School, and explore some planets! Next Week: Reach the end of Rannoch, the Turian homeworld! Our Patreon: http://patreon.com/squarerootspodcast Thanks to Steven Morris for his awesome theme! You can find him at: https://twitter.com/BeigeOnBeige and https://www.youtube.com/user/morrissteven Contact Square Roots! Twitter: @squarerootspod Facebook: https://www.facebook.com/groups/486022898258197/ Email: squarerootspodcast (at) gmail (dort) com

Silversun Strip Apartments. When you're here, you're family. Mass Effect 3 was an RPG event when it launched in 2012, and underneath the vitriolic reaction to its ending and multiple waves of DLC both expansive and reconstructive is an excellent shooter RPG. In today's episode of Retro Encounter, three panelists discuss not only Mass Effect 3's resolutions to the Krogan, Geth, and Reaper conflicts, but also the adventure, romance, and legacy of the Mass Effect trilogy. Featuring: Michael Sollosi, Wes Iliff, Jonathan Logan; Edited by Jonathan LoganOpening and ending music by Miles MorkriGet in Touch:RPGFan.comRPGFan ShopEmail us: retro@rpgfan.comTwitter: @rpgfancomInstagram: @rpgfancomFacebook: rpgfancomTwitch: rpgfancomRelated Links:Mass Effect 3 on RPGFan

We've been building toward it all season– it's time to stand up for the Krogan people and gain enough evidence to reveal Spender's dirty deeds. We're joined by Spectre A La Fete as we help our favorite Krogan Grandpa, Drack, retrieve the stolen seed vault! Special thanks to David Boyle for our amazing logo and to JT Music and Andrea Storm Kaden for the song Feels Like Home, which we use as our theme music.

First we rescue a Krogan named Eve (for lack of a better name), and then also we help out Grunt. It's a very Krogan-centric episode you might say. Patreon: https://patreon.com/lokathor Twitter: https://twitter.com/lokathor

Next up in the line of planets that try to kill us is Elaaden, home to the Krogan colony. We are joined by Ariel Pellman to explore this charming planet and leave it to the Krogan to thrive on a planet that is largely considered unlivable. Elaaden has it all; endless deserts, a water hoarder, scavengers ready to rob us blind, and Krogan blood feuds.Special thanks to David Boyle for our amazing logo and to JT Music and Andrea Storm Kaden for the song Feels Like Home, which we use as our theme music.

Omega is a hive of scum and villainy. If it's illegal, you can find it there. If someone wants to make a quick, unethical buck, you can make it. So what brings a Drell, a Krogan, and a Vorcha together? A simple thing: A mysterious client who hires both by reputation and by opportunity. This is a galaxy before humanity joined it. This is Mass Effect: Before Contact. Music Credits: Intro: Mass Effect Theme - Jack Wall & Sam Hulick Omega: Criminal Elements - Jack Wall Afterlife: Callista - Saki Kaskas Investigation: Finding Samara - Jack Wall Aria T'Loak: Lower Afterlife Music AKA Lo Fi Epic - The Techno Madness Mix - Jesse James Allen Outro: Farewell and Into the Inevitble - Sam Hulick Support the show on Patreon! For as little as a dollar you get access to all sorts of cool bonus content, and for $5 you get access to episodes a week early. https://www.patreon.com/BoogiemanBuddiesCast

There's no place like Home!  It is exhausting exploring post-apocalyptic wastelands and you need a rest after uniting a divided country to fight your father's army.  Sometimes, you just want to go home. Well, in today's episode, we discuss our favorite homes & bases in gaming.  That little comfortable place where you can talk to your favorite Krogan and upgrades your armor.  Maybe, you just want to look at your inventory while you drink Timefall Porter.  We are here to wistfully ponder what makes a good homebase!  Hair of the Dogcast is a proud member of the HyperX Podcast Network.  For more information check out podcast.hyperx.com! Contact Us: Twitter: @HOTDogcast Facebook: https://www.facebook.com/hairofthedogcast  Instagram: hairofthedogcast To see how you can support us and access a bunch of cool, exclusive perks, visit our Patreon page: https://www.patreon.com/hairofthedogcast We appreciate your support!  

Pop on your jetpack and brush off your Angaran dictionary, Kiaran and Adam have taken a one-way trip to the Andromeda galaxy in the largely criticised sequel of the Mass Effect trilogy. We talk about our history with the franchise, our impressions of the characters, Turian tongues, krogan genitalia, and much much more. But most importantly: is it really THAT bad?

Samara has to fight her daughter and Jack has to fight her past. Also, fun with an old Krogan on Omega!

The last of our "bad guy" factions is the Blood Pack, filled with Krogan and Vorcha, they seem like the faceless baddies the game just throws at our heroes when they need the lowest scum for us to shoot at, but is there more to them? Subscribe so you don't miss any Mass Effect Lorecast Podcast episodes, lore, and other Mass Effect content from Robots Radio! Support us on Patreon! https://patreon.com/masseffectlorecast Storyblocks.com: Storyblocks.com/robotsradio Want to support the show for no extra cost? Use the link to sign up for Game Pass now! Click: http://bit.ly/XBGPass Join us LIVE Sunday 10:30pm EST / 7:30pm PST: https://twitch.tv/robotsradio Discord: https://discord.gg/JXKfVhM Twitter: twitter.com/masseffectcast Email: masseffectlorecast@gmail.com Music: Screen Saver by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5715-screen-saver License: https://filmmusic.io/standard-license ROBOTSRADIO.net Learn more about your ad choices. Visit megaphone.fm/adchoices

Cast: Chris - GM Aaron - Theodore Ronin Hunter (Human Vanguard) Josh - Hilo'Vael Vas Wolfpack Nar Colepsi (Quarian Machinist) Seb - Korlus Runt (Krogan Battlemaster) (1.5 yrs old, looks “112 yrs”) Dave - Olka Ibn'taaj (Batarian Infiltrator) Session 12: New Detroit Vault City! Part 1 (A special DLC Episode) 2 months have passed since the full discovery of the Yithadi's plans and the recognition by the Council of the WOLFPACK's achievements as Pathfinders. Now, a friend has got some tickets to a concert of the hottest new musical group sweeping Heleus. Things, however, are never quite so relaxing, but really where would the fun be in that? Especially on the Krogan world of Elaaden.  Musical Credits:  NewsSting by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4124-newssting  License: https://filmmusic.io/standard-license

Understanding cancer is like assembling IKEA furniture. Hear me out. Both start with individual pieces that make up the final product. For a cabinet, it's a list of labeled precut plywood. For cancer, it's a ledger of genes that—through the Human Genome Project and subsequent studies—we know are somehow involved in cells mutating, spreading, and eventually killing their host. Yet without instructions, pieces of wood can't be assembled into a cabinet. And without knowing how cancer-related genes piece together, we can't decipher how they synergize to create one of our fiercest medical foes. It's like we have the first page of an IKEA manual, said Dr. Trey Ideker at UC San Diego. But “how these genes and gene products, the proteins, are tied together is the rest of the manual—except there's about a million pages worth of it. You need to understand those pages if you're really going to understand disease.” Ideker's comment, made in 2017, was strikingly prescient. The underlying idea is seemingly simple, yet a wild shift from previous attempts at cancer research: rather than individual genes, let's turn the spotlight on how they fit together into networks to drive cancer. Together with Dr. Nevan Krogan at UC San Francisco, a team launched the Cancer Cell Map Initiative (CCMI), a moonshot that peeks into the molecular “phone lines” within cancer cells that guide their growth and spread. Snip them off, the theory goes, and it's possible to nip tumors in the bud. This week, three studies in Science led by Ideker and Krogan showcased the power of that radical change in perspective. At its heart is protein-protein interactions: that is, how the cell's molecular “phone lines” rewire and fit together as they turn to the cancerous dark side. One study mapped the landscape of protein networks to see how individual genes and their protein products coalesce to drive breast cancer. Another traced the intricate web of genetic connections that promote head and neck cancer. Tying everything together, the third study generated an atlas of protein networks involved in various types of cancer. By looking at connections, the map revealed new mutations that likely give cancer a boost, while also pointing out potential weaknesses ripe for target-and-destroy. For now, the studies aren't yet a comprehensive IKEA-like manual of how cancer components fit together. But they're the first victories in a sweeping framework for rethinking cancer. “For many cancers, there is an extensive catalog of genetic mutations, but a consolidated map that organizes these mutations into pathways that drive tumor growth is missing,” said Drs. Ran Cheng and Peter Jackson at Stanford University, who weren't involved in the studies. Knowing how those work “will simplify our search for effective cancer therapies.” Cellular Chatterbox Every cell is an intricate city, with energy, communications systems, and waste disposal needs. Their secret sauce for everything humming along nicely? Proteins. Proteins are indispensable workhorses with many tasks and even more identities. Some are builders, tirelessly laying down “railway” tracks to connect different parts of a cell; others are carriers, hauling cargo down those protein rails. Enzymes allow cells to generate energy and perform hundreds of other life-sustaining biochemical reactions. But perhaps the most enigmatic proteins are the messengers. These are often small in size, allowing them to zip around the cell and between different compartments. If a cell is a neighborhood, these proteins are mailmen, shuttling messages back and forth. Rather than dropping off mail, however, they deliver messages by physically tagging onto other protein. These “handshakes” are dubbed protein-protein interactions (PPIs), and are critical to a cell's function. PPIs are basically the cell's supply chain, communications cable, and energy economy rolled into one massive infrastructure. Destroying just one PPI can lead a thriving cell to die. PPIs ar...

In this episode of the Epigenetics Podcast, we caught up with Ali Shilatifard from Northwestern University to talk about his work on targeting COMPASS to cure childhood leukemia. The Shilatifard Lab studies childhood leukemia and how it can potentially be treated using epigenetic targets. The team focuses on is SET1/COMPASS, a histone H3 lysine4 methylase. Ali Shilatifard was able to purify and identify its activity, with results published in 2001 in PNAS. This protein complex is conserved from yeast to drosophila to humans. Surprisingly, the Shilatifard Team could show that the catalytic activity of COMPASS is not necessary for viability of drosophila. Furthermore, they found that catalytic activity was not the decisive feature of the complex, but rather its role in the context of chromatin structure, in particular a protein domain that only spans 80 amino acids within the 4000 amino acid protein.   References Miller, T., Krogan, N. J., Dover, J., Erdjument-Bromage, H., Tempst, P., Johnston, M., Greenblatt, J. F., & Shilatifard, A. (2001). COMPASS: A complex of proteins associated with a trithorax-related SET domain protein. Proceedings of the National Academy of Sciences, 98(23), 12902–12907. https://doi.org/10.1073/pnas.231473398 Lin, C., Garruss, A. S., Luo, Z., Guo, F., & Shilatifard, A. (2013). The RNA Pol II Elongation Factor Ell3 Marks Enhancers in ES Cells and Primes Future Gene Activation. Cell, 152(1–2), 144–156. https://doi.org/10.1016/j.cell.2012.12.015 Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J., & Shilatifard, A. (2018). Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. Nature Medicine, 24(6), 758–769. https://doi.org/10.1038/s41591-018-0034-6 Morgan, M. A. J., & Shilatifard, A. (2020). Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation. Nature Genetics, 52(12), 1271–1281. https://doi.org/10.1038/s41588-020-00736-4   Related Episodes Cancer and Epigenetics (David Jones) Transcription and Polycomb in Inheritance and Disease (Danny Reinberg) Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Learn about whether being too clean makes kids sick; an ancient coronavirus epidemic; and a black hole-neutron star merger. Is being too hygienic making kids sick? These researchers say the public has it all wrong by Grant Currin Being clean and hygienic need not impair childhood immunity. (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-07/ucl-bca070221.php  Rook, G. A. W., & Bloomfield, S. F. (2021). Microbial exposures that establish immunoregulation are compatible with targeted hygiene. Journal of Allergy and Clinical Immunology, 148(1), 33–39. https://doi.org/10.1016/j.jaci.2021.05.008  ‌Cara, E. (2021, July 6). Being Clean Doesn't Have to Be Bad for Our Immune System, Scientists Say. Gizmodo; Gizmodo. https://gizmodo.com/being-clean-doesnt-have-to-be-bad-for-our-immune-system-1847238686  Genome study reveals East Asian coronavirus epidemic 20,000 years ago by Cameron Duke Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., Johnston, W. A., Krogan, N. J., Alexandrov, K., & Enard, D. (2021). An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. Current Biology. https://doi.org/10.1016/j.cub.2021.05.067  Queensland University of Technology (2021, June 24). Genome study reveals East Asian coronavirus epidemic 20,000 years ago. Phys.org. https://phys.org/news/2021-06-genome-reveals-east-asian-coronavirus.html  We got the first ever detection of a black hole gobbling up a neutron star by Briana Brownell Black holes swallow neutron stars like “Pac Man.” (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-06/anu-bh062521.php  ‌Astrophysicists detect first black hole-neutron star mergers. (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-06/nu-adf062821.php  ‌Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., ... & Boudart, V. (2021). Observation of gravitational waves from two neutron star–black hole coalescences. The Astrophysical Journal Letters, 915(1), L5. https://iopscience.iop.org/article/10.3847/2041-8213/ac082e/pdf Betz, E. (2020). How Big Are Neutron Stars? Discover Magazine; Discover Magazine. https://www.discovermagazine.com/the-sciences/how-big-is-a-neutron-star  ‌By Pallab Ghosh. (2021, June 29). Rare black hole and neutron star collisions sighted twice in 10 days. BBC News; BBC News. https://www.bbc.com/news/science-environment-57639520  ‌What Is a Black Hole? (2015). NASA. https://www.nasa.gov/audience/forstudents/k-4/stories/nasa-knows/what-is-a-black-hole-k4.html  Follow Curiosity Daily on your favorite podcast app to learn something new every day withCody Gough andAshley Hamer. Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. See omnystudio.com/listener for privacy information.

The Krogans are one of the toughest and most violent of the sentient races in the galaxy, but they are also strangely evolved more like prey than predators. What caused this peculiar evolution and what do we know about their history? Subscribe so you don't miss any Mass Effect Lorecast Podcast episodes, lore, and other Mass Effect content from Robots Radio! Support us on Patreon! https://patreon.com/masseffectlorecast Storyblocks.com: Storyblocks.com/robotsradio Want to support the show for no extra cost? Use the link to sign up for Game Pass now! Click: http://bit.ly/XBGPass Join us LIVE Sunday 10:30pm EST / 7:30pm PST: https://twitch.tv/robotsradio Discord: https://discord.gg/JXKfVhM Twitter: twitter.com/masseffectcast Email: masseffectlorecast@gmail.com Music: Screen Saver by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5715-screen-saver License: https://filmmusic.io/standard-license https://robotsradio.net Learn more about your ad choices. Visit megaphone.fm/adchoices

It's another week at the Tiltcast!  E3 is done!  We are glad to be back talking about regular games again.  We start off talking about Jason's new PC build and then we bring the "new" with some Ragnarock.  We followed that up with what we picked up on the Steam Sale.  We also talked quite about what changed with ESO and at the very end we remembered what is awful about Dark Alliance.  Tune in for a very full episode! EpisodeElder Scrolls OnlineRagnarockDungeons and Dragons: Dark Alliance

This week, Kat and Nadia go massive on Mass Effect! USgamer alumni and absolute Mass Effect sage Eric Van Allen joins the podcast to have a long, involved talk about Mass Effect Legendary Edition. He also lends a sympathetic ear to Nadia's lament over how Wrex is not a romance option. Once their Krogan thirst is slaked, the crew then moves on to talking about Nier Replicant and Pokemon Snap. You will be shocked, shocked to learn Nadia uploaded a PG-13 picture and promptly received a rebuke email from Nintendo. Also in this episode: Neo The World Ends With You is making post-hardcore cool again, Skyrim discourse veers into cannibalism and Cinnabon, and congratulations Australia, Hideo Kojima's content is no longer illegal in your fair country!

What does it take to push back against the devastating decisions made by your own people—decisions that you took a part in, that your intellect helped to develop? Is it possible to atone for these past horrors? Mordin Solus, Mass Effect's very model of a scientist Salarian, grapples with these questions in regards to the genophage, a plague unleashed by the Salarians on the Krogan to reduce their birthrate to nearly zero. In this episode, my guest Sam (aka N7 Legend of the Mass Effect Lorecast) and I tackle these same questions, looking closely at Mordin's choices, his complicated story arc, and his ultimate redemption... because it had to be Mordin. Someone else might have gotten it wrong. Does Fyre cry during this episode? Spoiler alert - she sure does. Mordin's wiki: https://masseffect.fandom.com/wiki/Mordin_Solus Connect with Sam! https://twitter.com/N7TheLegend https://twitter.com/masseffectcast https://www.twitch.tv/kungfu_kangaroo Support the show on Patreon! https://www.patreon.com/FyreWriter?fan_landing=true Join the Discord! https://discord.gg/wba2x7j Want to discuss your favorite NPC? Sign up here! https://forms.gle/AevG5WHA7yQ6bCqS7 Connect with the show! https://twitter.com/PixelPeoplePod Chat with FyreWriter directly and check out her streams! https://twitter.com/FyreWriter https://www.twitch.tv/fyrewriter Learn more about the Robots Radio Rocket Club and become a member! https://robotsradio.net/rocket-club/ Music by Elias Ali & Adam Brookes

This episode is "out of this world" ... Figuratively and literally. Maybe just figuratively. We're one day closer to the Mass Effect Legendary Edition release, now is the time to prepare our hearts and minds. Facebook - https://www.facebook.com/GreaterMythos Twitter - https://mobile.twitter.com/GreaterMythos

The Rachni "solution" created a new Krogan problem... and that required another "solution" - the genophage. Here's what we know. Plus, the Mass Effect Legendary edition comes out soon! We talk about our plans as that gets closer to launch. (It went gold!) Subscribe so you don't miss any Mass Effect Lorecast Podcast episodes, lore, and other Mass Effect content from Robots Radio! Support us on Patreon! https://patreon.com/masseffectlorecast Storyblocks.com: Storyblocks.com/robotsradio Want to support the show for no extra cost? Use the link to sign up for Game Pass now! Click: http://bit.ly/XBGPass Links: Join us LIVE Sunday 10:30pm EST / 7:30pm PST: https://twitch.tv/robotsradio Discord: https://discord.gg/JXKfVhM Twitter: twitter.com/masseffectcast Email: masseffectlorecast@gmail.com Music: Screen Saver by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5715-screen-saver License: https://filmmusic.io/standard-license https://robotsradio.net Learn more about your ad choices. Visit megaphone.fm/adchoices

How dangerous were the Rachni and was the "solution" worth it? Subscribe so you don't miss any Mass Effect Lorecast Podcast episodes! Support us on Patreon! https://patreon.com/masseffectlorecast Storyblocks.com: Storyblocks.com/robotsradio Want to support the show for no extra cost? Use the link to sign up for Game Pass now! Click: http://bit.ly/XBGPass Links: Join us LIVE Sunday 10:30pm EST / 7:30pm PST: https://twitch.tv/robotsradio  Discord: https://discord.gg/JXKfVhM Twitter: twitter.com/masseffectcast Email: masseffectlorecast@gmail.com Music: Screen Saver by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5715-screen-saver License: https://filmmusic.io/standard-license https://robotsradio.net Learn more about your ad choices. Visit megaphone.fm/adchoices

New world who dis? In this weeks episode we talk about Mass Effects Krogan and we start a 2nd season. Using the Krogan's lore we create 9 kingdom's and an evil greater deity to set the beginning and tone of our new world for season 2 of Dungeoneered. Thanks to Arcane Anthems for offering amazing royalty free music for nerds like us, we used their amazing tracks Shillelagh (Spirit of Brynn) and Solemn Rest for our intro and outro respectively. For any of you looking to email us questions don't forget to put in the subject line HELP when you email us at Dungeoneered@gmail.com

In this episode we talk about the Rachni from Mass Effect, we also set up next weeks topic of the Krogan also from Mass Effect. We use this to add to our world and create enemies in the history that massively affected the world... but we quickly get distracted and add other things to our world as well. Thanks to Arcane Anthems for offering amazing royalty free music for nerds like us, we used their amazing tracks Shillelagh (Spirit of Brynn) and Solemn Rest for our intro and outro respectively. For any of you looking to email us questions don't forget to put in the subject line HELP when you email us at Dungeoneered@gmail.com

The time is finally here! Case Aiken joins us to discuss the most sought after mission of Reignite’s history: Priority Tuchanka. We talk about Krogan history, alternate paths, and losing a friend. Fandom Corner focuses on the constantly improving Bioware Store! Special thanks to David Boyle for our amazing logo and to Dan Bull for the song MASS EFFECT RAP, which we use as our theme.

One of the great loves of Matt’s life, Professor John Lestrange, joins us to discuss a secret mission as given to us by our pal Wrex. We talk genocide, the futility of choice, and rachni bull shit. Fandom Corner features a cute Futurama mashup and a shop specifically geared toward MJ’s interests. Special thanks to David Boyle for our amazing logo and to Dan Bull for the song MASS EFFECT RAP, which we use as our theme.

This week we actually have... Mostly good news?!? That's unexpected, but certainly welcome. Not a ton of game talk this week, but we do dive into Atelier Ryza and Little Hope, give Umineko a few minutes, and talk about some of the games we hope to be checking out for Game of the Year! But dang, check out that news section. We got to say nice things about Bioware! And representation in games!! And the state of the United States of America!!! Much love y'all. Links mentioned in episode: Underpaid and Overworked: Being an Animator in Japan https://www.youtube.com/watch?v=Tvj-XnVKQI8 Is Madeline Canonically Trans? https://maddythorson.medium.com/is-madeline-canonically-trans-4277ece02e40 Timestamps: 00:07:45 - Atelier Ryza 00:23:18 - Umineko & what to play next? 00:37:27 - Little Hope 00:47:55 - Caves of Qud Newwwwssssss 00:54:00 - Extra Life!! 00:55:30 - PS5 and Xbox reviews are up 01:08:57 - THPS 1+2 got a biiiiigggg update 01:09:58 - Mass Effect Trilogy coming in 2021 01:22:03 - Anthem - it’s still a thing 01:29:48 - PSA: Destiny 2’s original Campaign will be leaving soon 01:33:10 - Gears POP! RIP 01:41:13 - Fortnite is back on iOS! Kinda 01:44:17 - Codemasters got bought up by Take Two! 01:46:47 - Sony’s got all the anime now 01:51:44 - Source code for Watch Dogs Legion got leaked yo (also Capcom) 01:54:05 - AMD! The new CPUs are wild 02:03:03 - Celeste writer pens a wonderful article about Maddy 02:11:25 - Miles Morales knows sign language 02:14:05 - There is a new United States President. Dogs will be in the white house again. https://fyx.space https://podchaser.com/gamingfyx https://twitter.com/fyxpodcasts

This week we actually have... Mostly good news?!? That's unexpected, but certainly welcome. Not a ton of game talk this week, but we do dive into Atelier Ryza and Little Hope, give Umineko a few minutes, and talk about some of the games we hope to be checking out for Game of the Year! But dang, check out that news section. We got to say nice things about Bioware! And representation in games!! And the state of the United States of America!!! Much love y'all. Links mentioned in episode: Underpaid and Overworked: Being an Animator in Japan https://www.youtube.com/watch?v=Tvj-XnVKQI8 Is Madeline Canonically Trans? https://maddythorson.medium.com/is-madeline-canonically-trans-4277ece02e40 Timestamps: 00:07:45 - Atelier Ryza 00:23:18 - Umineko & what to play next? 00:37:27 - Little Hope 00:47:55 - Caves of Qud Newwwwssssss 00:54:00 - Extra Life!! 00:55:30 - PS5 and Xbox reviews are up 01:08:57 - THPS 1+2 got a biiiiigggg update 01:09:58 - Mass Effect Trilogy coming in 2021 01:22:03 - Anthem - it's still a thing 01:29:48 - PSA: Destiny 2's original Campaign will be leaving soon 01:33:10 - Gears POP! RIP 01:41:13 - Fortnite is back on iOS! Kinda 01:44:17 - Codemasters got bought up by Take Two! 01:46:47 - Sony's got all the anime now 01:51:44 - Source code for Watch Dogs Legion got leaked yo (also Capcom) 01:54:05 - AMD! The new CPUs are wild 02:03:03 - Celeste writer pens a wonderful article about Maddy 02:11:25 - Miles Morales knows sign language 02:14:05 - There is a new United States President. Dogs will be in the white house again. https://fyx.space https://podchaser.com/gamingfyx https://twitter.com/fyxpodcasts

This week we actually have... Mostly good news?!? That's unexpected, but certainly welcome. Not a ton of game talk this week, but we do dive into Atelier Ryza and Little Hope, give Umineko a few minutes, and talk about some of the games we hope to be checking out for Game of the Year! But dang, check out that news section. We got to say nice things about Bioware! And representation in games!! And the state of the United States of America!!! Much love y'all. Links mentioned in episode: Underpaid and Overworked: Being an Animator in Japan https://www.youtube.com/watch?v=Tvj-XnVKQI8 Is Madeline Canonically Trans? https://maddythorson.medium.com/is-madeline-canonically-trans-4277ece02e40 Timestamps: 00:07:45 - Atelier Ryza 00:23:18 - Umineko & what to play next? 00:37:27 - Little Hope 00:47:55 - Caves of Qud Newwwwssssss 00:54:00 - Extra Life!! 00:55:30 - PS5 and Xbox reviews are up 01:08:57 - THPS 1+2 got a biiiiigggg update 01:09:58 - Mass Effect Trilogy coming in 2021 01:22:03 - Anthem - it's still a thing 01:29:48 - PSA: Destiny 2's original Campaign will be leaving soon 01:33:10 - Gears POP! RIP 01:41:13 - Fortnite is back on iOS! Kinda 01:44:17 - Codemasters got bought up by Take Two! 01:46:47 - Sony's got all the anime now 01:51:44 - Source code for Watch Dogs Legion got leaked yo (also Capcom) 01:54:05 - AMD! The new CPUs are wild 02:03:03 - Celeste writer pens a wonderful article about Maddy 02:11:25 - Miles Morales knows sign language 02:14:05 - There is a new United States President. Dogs will be in the white house again. https://fyx.space https://podchaser.com/gamingfyx https://twitter.com/fyxpodcasts

Side Quests is back and this episode's host is streamer, BioWare super fan and the Herald of Andraste, Iza aka Grumpy Krogan! The game they are talking about today is Dragon Age: Inquisition by BioWare and EA!   You can find this episode's host on twitter or follow them on Twitch!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.18.256776v1?rss=1 Authors: Dominguez Andres, A., Feng, Y., Campos, A. R., Yin, J., Yang, C.-C., James, B., Murad, R., Kim, H., Deshpande, A. J., Gordon, D. E., Krogan, N. J., Pippa, R., Ronai, Z. A. Abstract: Disrupted antiviral immune responses are associated with severe COVID-19, the disease caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of the viral genome contains a putative transmembrane domain, interacts with membrane proteins in multiple cellular compartments, and impairs antiviral processes in a lung epithelial cell line. Proteomic, interactome, and transcriptomic analyses, combined with bioinformatic analysis, revealed that expression of only this highly unstable small viral protein impaired interferon signaling, antigen presentation, and complement signaling, while inducing IL-6 signaling. Furthermore, we showed that interfering with ORF9c degradation by either proteasome inhibition or inhibition of the ATPase VCP blunted the effects of ORF9c. Our study indicated that ORF9c enables immune evasion and coordinates cellular changes essential for the SARS-CoV-2 life cycle. Copy rights belong to original authors. Visit the link for more info

Ben and Tao don their tricornes, unsheath their long swords and spare no prisoners as they ravage the virgin lands of Teer Fradee in colonialist RPG epic, Greedfall. Tao takes issue with the representation of race and colonialism, while Ben takes umbrage with just about everything else. Despite the theme, diplomacy goes out the window and harsh truths are aired. Major spoilers from around half way through. Content Warning: PEGI 16. Very strong language. Vehement criticism. The slaughter of innocents. General tyranny. Clarifications: Petrus/ Heimlock is voiced by English actor Steven Hartley. Dragon's Dogma is an ARPG hack n slash developed and published by Capcom in 2012. In Mass Effect 2, the Krogan are a species of large reptilian bipeds. Spider’s previous game was The Technomancer (2016) Audio extracts: Adele - ‘Skyfall’ Brian Blessed Masterchef UK Martin Harley - ‘Money Don’t Matter’ Monty Python’s ‘The Spanish Inquisition’ Fiona Shaw as Carolyn Martens in ‘Killing Eve’. Dragon Age: Inquisition OST Dragon’s Dogma Fable OST The Lord of the Rings: The Two Towers Civilisation 4 OST - ‘Out at Sea’ The Apprentice UK

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.248104v1?rss=1 Authors: Finneran, P., Soucheray, M., Wilson, C., Otten, R., Buosi, V., Krogan, N. J., Swaney, D., Theobald, D., Kern, D. Abstract: The specificity of phosphorylation by protein kinases is essential to the integrity of biological signal transduction. While peptide sequence specificity for individual kinases has been examined previously, here we explore the evolutionary progression that has led to the modern substrate specificity of two non-receptor tyrosine kinases, Abl and Src. To efficiently determine the substrate specificity of modern and reconstructed ancestral kinases, we developed a method using mammalian cell lysate as the substrate pool, thereby representing the naturally occurring substrate proteins. We find that the oldest tyrosine kinase ancestor was a promiscuous enzyme that evolved through a more specific last common ancestor into a specific human Abl. In contrast, the parallel pathway to human Src involved a loss of substrate specificity, leading to general promiscuity. These results add a new facet to our understanding of the evolution of signaling pathways, with both subfunctionalization and neofunctionalization along the evolutionary trajectories. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.08.238469v1?rss=1 Authors: Schoof, M., Faust, B., Saunders, R. A., Sangwan, S., Rezelj, V. V., Hoppe, N., Boone, M., Billesboelle, C., Zimanyi, M., Deshpande, I., Liang, J., Anand, A. A., Dobzinski, N., Zha, B. S., Barsi-Rhyne, B., Bleyy, V., Barile-Hill, A. W., Gupta, S., Simoneau, C. R., Leon, K., White, K. M., Nock, S., Liu, Y., Krogan, N. J., Ralston, C. Y., Swaney, D. L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium,, Walter, P., Manglik, A. Abstract: Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host cell receptor angiotensin converting enzyme 2 (ACE2). Disruption of this interaction confers potent neutralization of viral entry, providing an avenue for vaccine design and for therapeutic antibodies. Here, we develop single-domain antibodies (nanobodies) that potently disrupt the interaction between the SARS-CoV-2 Spike and ACE2. By screening a yeast surface-displayed library of synthetic nanobody sequences, we identified a panel of nanobodies that bind to multiple epitopes on Spike and block ACE2 interaction via two distinct mechanisms. Cryogenic electron microscopy (cryo-EM) revealed that one exceptionally stable nanobody, Nb6, binds Spike in a fully inactive conformation with its receptor binding domains (RBDs) locked into their inaccessible down-state, incapable of binding ACE2. Affinity maturation and structure-guided design of multivalency yielded a trivalent nanobody, mNb6-tri, with femtomolar affinity for SARS-CoV-2 Spike and picomolar neutralization of SARS-CoV-2 infection. mNb6-tri retains stability and function after aerosolization, lyophilization, and heat treatment. These properties may enable aerosol-mediated delivery of this potent neutralizer directly to the airway epithelia, promising to yield a widely deployable, patient-friendly prophylactic and/or early infection therapeutic agent to stem the worst pandemic in a century. Copy rights belong to original authors. Visit the link for more info

Mask Etiquette: People be geeking and not wearing their masks, it's wild out there!BIOVYZR: A mask that goes too far for nerds.Galactic Starcruiser: Let's go over how Jeff gets dragged to theme parks for his own good.JORDAN!, ISIAH!, THE LAST DANCE!, ASSHOLE!, SANTANA!, ROB THOMAS!, SMOOTH!, SCREENPLAY!, GAY SCARFACE!, GAY GUY!, EVERYONE NOT IN THIS ROOM RIGHT NOW JIM!, SUCK ALL THE DICKS!, YA'LL READY FOR THIS!?, BLACK BETTY!, UNDERAGE!, BUSSY!, BLACK PILLED!, J-NEELY!, PEDOPHILE!, RED PILL!, BLACK PILL!, BLUE PILL!, HUNCHBACK!, KILL LIST!, JOE BOB BRIGGS!, SLAM A RAIL!, THE LAST DRIVE IN!, MASK ETIQUETTE!, COSTCO!, VEGAS!, KICKED OUT!, COMPANY POLICY!, SLOB!, WOKE UP IN A FREE COUNTRY!, SASS!, TMZ!, PUSSY LITTLE BITCH!, GOVERNMENT!, CHINA!, REBEL!, ANTI-AUTHORITY!, GELSON'S!, MICHAEL JACKSON!, I WANNA ROCK WITH YOU!, MEDICAL!, DANCING!, CART CLEANING!, KRISTIN!, BIOVYZR!, GOFUNDME!, TOO FAR!, OVERBOARD!, FILTERS!, INDIEGOGO!, QUARANTINE!, HOOD!, KROGAN!, GERMOPHOBE!, DRIPPY!, WATER PROOF!, DISNEY WORLD!, STAR WARS HOTEL!, GALACTIC STARCRUISER!, TRIPS!, LINKIN PARK!, ROCKIN ROLLER COASTER!, AVENGERS!, RENAISSANCE FAIR!, LOVE IT!, CLIP IT!, BOSS NASS!, CHINA!, EUROPE!, CRUISE!, WATER SLIDE!, ATLANTIS!, COVE POOL!, WATER PARKS!, HATE THEM!, STORMTROOPERS!, DRUNK!, EXPERIENCE!, CANTINA!, ALCOHOLIC DRINKS!, COLLECTIBLE CUPS!, HARRY POTTER RIDE!, FUZZY TAUNTAUN!, JEDI MIND TRICK!, CUSTOM LIGHTSABER!, HORROR NIGHTS!, HALLOWEEN!, HAUNTED HOUSE!, MIKE FREAK OUT!, TEXAS CHAINSAW MASSACRE 2!, CHOP TOP!, RAILS!, SOBER!, OFF STREAM!You can find the videos from this episode at our Discord RIGHT HERE!

Did you know Krogans have 4 testicles called a Quad and that Elcor are known to be both serial killers and Shakespearean actors? The Raw Dogs return to finish their discussion of the Rise and Fall of Bioware!  Stoy from EXPCast returns as we gush over the Mass Effect and Dragon Age Trilogies... then we talk about Andromeda and Anthem (Yikes) and we find out once and for all is Brad Or Dylan going to be your romance option? Like and Subscribe for a chance to win a Hanar Shish-Kabobs

We are joined (again) by a very special guest!!! Jeffrey Davis joins us in our neverending quest to bring content which will make you think, ask questions, tilt your head in confusion, and dab. Allyson is nearing the conclusion of her Danganronpa saga, Andre gets deep into VR and Resident Evil Resistance, Pat is all about 1970s Spain, Sam will forever be talking about Cold Steel, Alex has Visual Novels and Anime, and Jeff gives wonderful insight into the workings of leitmotif and the power of a great musical score. Timestamps: 00:05:14 - Trails of Cold Steel 3 00:36:53 - Sakuya Izayoi Gives You Advice And Dabs: Nitori Kawashiro Offers You Advice In Exchange For Cucumbers And Eats The Cucumbers 00:44:57 - The Fox Awaits Me 00:46:26 - A Summer's End - Hong Kong 1986 00:48:57 - XCOM: Chimera Squad 00:59:42 - Danganronpa 2 & Danganronpa V3 01:18:17 - The Flower Collectors 01:38:04 - Resident Evil: Resistance(?) 01:46:17 - Pixel Ripped 1995 01:54:27 - Final Fantasy 7 Remake: Leitmotif and What a Remake Means for Music 02:37:42 - Newwwwssssss https://fyx.space https://twitter.com/fyxpodcasts https://podchaser.com/gamingfyx

We are joined (again) by a very special guest!!! Jeffrey Davis joins us in our neverending quest to bring content which will make you think, ask questions, tilt your head in confusion, and dab. Allyson is nearing the conclusion of her Danganronpa saga, Andre gets deep into VR and Resident Evil Resistance, Pat is all about 1970s Spain, Sam will forever be talking about Cold Steel, Alex has Visual Novels and Anime, and Jeff gives wonderful insight into the workings of leitmotif and the power of a great musical score. Timestamps: 00:05:14 - Trails of Cold Steel 3 00:36:53 - Sakuya Izayoi Gives You Advice And Dabs: Nitori Kawashiro Offers You Advice In Exchange For Cucumbers And Eats The Cucumbers 00:44:57 - The Fox Awaits Me 00:46:26 - A Summer’s End - Hong Kong 1986 00:48:57 - XCOM: Chimera Squad 00:59:42 - Danganronpa 2 & Danganronpa V3 01:18:17 - The Flower Collectors 01:38:04 - Resident Evil: Resistance(?) 01:46:17 - Pixel Ripped 1995 01:54:27 - Final Fantasy 7 Remake: Leitmotif and What a Remake Means for Music 02:37:42 - Newwwwssssss https://fyx.space https://twitter.com/fyxpodcasts https://podchaser.com/gamingfyx

We are joined (again) by a very special guest!!! Jeffrey Davis joins us in our neverending quest to bring content which will make you think, ask questions, tilt your head in confusion, and dab. Allyson is nearing the conclusion of her Danganronpa saga, Andre gets deep into VR and Resident Evil Resistance, Pat is all about 1970s Spain, Sam will forever be talking about Cold Steel, Alex has Visual Novels and Anime, and Jeff gives wonderful insight into the workings of leitmotif and the power of a great musical score. Timestamps: 00:05:14 - Trails of Cold Steel 3 00:36:53 - Sakuya Izayoi Gives You Advice And Dabs: Nitori Kawashiro Offers You Advice In Exchange For Cucumbers And Eats The Cucumbers 00:44:57 - The Fox Awaits Me 00:46:26 - A Summer's End - Hong Kong 1986 00:48:57 - XCOM: Chimera Squad 00:59:42 - Danganronpa 2 & Danganronpa V3 01:18:17 - The Flower Collectors 01:38:04 - Resident Evil: Resistance(?) 01:46:17 - Pixel Ripped 1995 01:54:27 - Final Fantasy 7 Remake: Leitmotif and What a Remake Means for Music 02:37:42 - Newwwwssssss https://fyx.space https://twitter.com/fyxpodcasts https://podchaser.com/gamingfyx

We are joined (again) by a very special guest!!! Jeffrey Davis joins us in our neverending quest to bring content which will make you think, ask questions, tilt your head in confusion, and dab. Allyson is nearing the conclusion of her Danganronpa saga, Andre gets deep into VR and Resident Evil Resistance, Pat is all about 1970s Spain, Sam will forever be talking about Cold Steel, Alex has Visual Novels and Anime, and Jeff gives wonderful insight into the workings of leitmotif and the power of a great musical score. Timestamps: 00:05:14 - Trails of Cold Steel 3 00:36:53 - Sakuya Izayoi Gives You Advice And Dabs: Nitori Kawashiro Offers You Advice In Exchange For Cucumbers And Eats The Cucumbers 00:44:57 - The Fox Awaits Me 00:46:26 - A Summer’s End - Hong Kong 1986 00:48:57 - XCOM: Chimera Squad 00:59:42 - Danganronpa 2 & Danganronpa V3 01:18:17 - The Flower Collectors 01:38:04 - Resident Evil: Resistance(?) 01:46:17 - Pixel Ripped 1995 01:54:27 - Final Fantasy 7 Remake: Leitmotif and What a Remake Means for Music 02:37:42 - Newwwwssssss https://fyx.space https://twitter.com/fyxpodcasts https://podchaser.com/gamingfyx

We are joined (again) by a very special guest!!! Jeffrey Davis joins us in our neverending quest to bring content which will make you think, ask questions, tilt your head in confusion, and dab. Allyson is nearing the conclusion of her Danganronpa saga, Andre gets deep into VR and Resident Evil Resistance, Pat is all about 1970s Spain, Sam will forever be talking about Cold Steel, Alex has Visual Novels and Anime, and Jeff gives wonderful insight into the workings of leitmotif and the power of a great musical score. Timestamps: 00:05:14 - Trails of Cold Steel 3 00:36:53 - Sakuya Izayoi Gives You Advice And Dabs: Nitori Kawashiro Offers You Advice In Exchange For Cucumbers And Eats The Cucumbers 00:44:57 - The Fox Awaits Me 00:46:26 - A Summer’s End - Hong Kong 1986 00:48:57 - XCOM: Chimera Squad 00:59:42 - Danganronpa 2 & Danganronpa V3 01:18:17 - The Flower Collectors 01:38:04 - Resident Evil: Resistance(?) 01:46:17 - Pixel Ripped 1995 01:54:27 - Final Fantasy 7 Remake: Leitmotif and What a Remake Means for Music 02:37:42 - Newwwwssssss https://fyx.space https://twitter.com/fyxpodcasts https://podchaser.com/gamingfyx

Nelson Lugo returns to Reignite, with plenty of f-bombs to share. We discuss Krogan culture, puberty, and knowing when to headbutt instead of argue. Fandom Corner features sculptures of our favorite lizard son made by SofikoSculpts on Etsy. Special thanks to David Boyle for our amazing logo and to Dan Bull for the song MASS EFFECT RAP, which we use as our theme.

In our penultimate Mass Effect: Andromeda episode we've got some loose ends to tie up. We've got to settle things between the exiles and the Initiative, see if we can patch things up with the Krogan, and learn some more about the Kett's inner workings along the way. It's time for some real OWBS, friends. Enjoy the show! Become a Normandy FM patron: http://patreon.com/normandyfm Follow us on Twitter: Normandy FM: @normandyfmshow Eric: @seamoosi Kenneth: @shepardcdr

Nakmor Drack's on the hunt for someone sabotaging the Krogan's livelihood in Andromeda. Naturally, we're here to help. Constantly Calibrating's Josh Silverman comes aboard the Tempest to run through our Krogan grandfather's loyalty mission, his relationship with his clan, and how Kesh gave him a new lease on life. Enjoy the show! Become a Normandy FM patron: http://patreon.com/normandyfm Follow us on Twitter: Normandy FM: @normandyfmshow Eric: @seamoosi Kenneth: @shepardcdr Josh: @BearPunch

MJ and Matt are off to deal with the Blue Suns again, this time to pick up a Krogan warlord who had dealings with The Collectors. After fighting mercenaries and battle hungry krogan, MJ & Matt end up with a different krogan than they planned. Aside from Matt’s devout love of Steve Blum, fandom corner highlights Less Than Stellar, an actual play podcast set in the Mass Effect Universe. Special thanks to David Boyle for our amazing logo and to Dan Bull for the song MASS EFFECT RAP, which we use as our theme.

It's a fateful day for the Krogan race as we head to Tuchanka to cure the Genophage...or do we? We talk about the various ways the trip the Shroud can go, and give a proper goodbye to an old friend on the way. It's a somber one this week, folks. Enjoy the show! Become a Normandy FM patron: http://patreon.com/normandyfm Follow us on Twitter: Normandy FM: @normandyfmshow Eric: @seamoosi Kenneth: @shepardcdr

It's time to dive headfirst into intergalactic diplomacy. The Turians need the Krogan's help in holding Palavan before they can commit resources to the Crucible, and the Krogans have one condition: a cure for the Genophage. Jay Malone returns to join us on a trip to the Salarian homeworld, where we meet the last hope for the Krogan race. After that, Wrex has a favor to ask about some missing scouts and we stop by the Citadel to check in with Miranda. Enjoy the show! Become a Normandy FM patron: http://patreon.com/normandyfm Follow us on Twitter: Normandy FM: @normandyfmshow Eric: @seamoosi Kenneth: @shepardcdr Jay: @surfingkane

Julian Titus from Nerds Without Pants joins Jim and John as they decide if the Miracle of Sound Commander Shepherd song deserves a Renegade or Paragon interrupt! This episode contains a careful review of the imagery used by Miracle of Sound, as well as a mailbag full of questions about Krogan genitals, Crossing Jordan, Asari babies, and Normandy crew slash fiction. Plus basic misunderstandings of microfilm! Level Up: 03:40 Commander Shepherd Review: 13:40 Mailbag: 38:10 Please find Miracle of Sound's Commander Shepherd song here: https://www.youtube.com/watch?v=HiRDJLcYua0 Our theme song for this series is by Sophie Marlon, check out her violin covers of tons of game themes on YouTube at Sophie Marlon: https://www.youtube.com/channel/UCET7Q5ZMfzqlgVf17AB-6DQ BANDCAMP: https://sophiemarlon.bandcamp.com/ INSTAGRAM: @sophiemarlonansems https://www.instagram.com/sophiemarlonansems/ TWITTER: @SophieMarlon https://twitter.com/SophieMarlon FACEBOOK: https://www.facebook.com/sophiemarlonansems Twitter: @squarerootspod Facebook: https://www.facebook.com/groups/486022898258197/ Email: squarerootspodcast (at) gmail (dort) com

Mark and Jessica talk about games and good books, weird marriages, and the difficulties building Mass Effect Andromeda, all this week. Thank you to Leon for the use of our theme song, Honey Milk Island. Check out Leon's music at http://soundcloud.com/leyawn. Support PauseCast by becoming a Patron, at http://patreon.com/pausecastshow.

This week Brando and Mike watch the Mass Effect: Andromeda story trailer, go over some news, and look at the possibility of a next-gen Xbox. Check us out @gameaddictsplay on Facebook, Twitter and Instagram! Check out the podcast on iTunes, Podbean, Stitcher, and Google Play Music!

Join Roger and Vince as they discuss Switch, Mass Effect: Andromeda, Project Re Fantasy, Torment: Tides of Numenera, and more. iTunes | Stitcher | RSS feed If you enjoy the show, please make certain to stop by iTunes and leave us a review!

This (past) week, Jessica gets started on Stardew Valley, Mark plays more Moon Hunters, both talk about some news, and Jessica wonders about her sexual opportunities with krogans. We also talk about some ideal games!

Such strange times we live in...Pittsburghese reaches Oxford, here's your chance to become a Krogan, the ongoing saga of Obama and his ever-disappearing fucks, TEAM JOLIE 5EVER.

At Phoenix Comicon 2016, Joshua Silverman (Editor-in-Chief), Brian McDaniel (Head of Business Development), and Thaddeus Adams (Content Development Manager) walked into a room at the Phoenix Convention Center and discussed Sexuality in Mass Effect. That's right, we tackled the topics that have been on Mass Effect fan's minds for nearly a decade now: If a Krogan has four testicles, how many dicks do they have? Can we fill a room with people wanting to discuss Turian dicks? What is Geth sexuality? Is it possible to have a serious conversation about Sexuality in Mass Effect? These questions, and many more, were answered to some degree during our Phoenix Comicon panel; a panel that was such an overwhelming success that we can't wait to do it again next year! So sit back and join us as we take a deep look into Sexuality in Mass Effect.   The "Sexy Garrus" featured in our podcast feature image can be found here and is not owned, nor was it created by Constantly Calibrating.  

The RnG crew fosters a lively discussion on race relations with other species.  Go out there and hug a Krogan today.

In this episode we discuss the Rachni Wars and the resulting Krogan uplifting, as well as the ensuing Krogan rebellions and eventual deployment of the biological weapon known as the genophage. Ethan Bleskie returns as guest.

Thanks to Jon for playing with us again! You can find Kobolds Ate My Baby here.   Subscribe via iTunes Subscribe via RSS Please follow me on Twitter or send us an email at theleviathanfiles@gmail.com Follow the rest of the cast, too: Dan – SJ – Dylan – Chris

The Gang discuss their latest gaming addictions, Spider-Gwen, and the world of Streaming music services. Special Guest @RevDev 

A technical glitch of somebody losing our headphone splitter means that Euan is left a little high and dry before this record so wasn’t able to join us. Tom, Alan and Cam instead talk through the Mass Effect series (Cam currently on 2, Tom blasting his way through 3), Alan starts singing Erasure as he plays Robot Unicorn Attack and WWE Wrestlefest on his brand new iPad which he ended up queuing for on release day. For some reason this ends up with us talking about the 1987 He-Man movie in far too much detail. The situation with Game is the topic for our half arsed attempt at a news section in which Cam edited out seven and a half minutes of waffle about Tesco. That’s waffle about Tesco, not buying waffles in Tesco. Alan then opens his Retro games Emporium with a talk about the Dizzy series from Codemasters. It leads to a lot of talk about eggs. That’s just eggs, not buying eggs in Tesco. Cam reviews both I Am Alive and Street Fighter x Tekken whilst Tom casts his critical eye over Mass Effect 3. Alan meanwhile considers a new career move. We apologise for the late running of the podcast, this was due to leaves on the line. Enjoy Episode 3.3.

When the crew isn’t going to Risa to buy a Krogan, they’re bringing you the latest news from the RPG industry. South Park is getting... The post RPGCast – Episode 202: “This One Time at Bandit Camp” appeared first on RPGamer.

Headset Abuse: 07/09/11 Discover the dangers of being stuck in a room of people full of chicken in this weeks podcast as we discuss Deus Ex, Free NES games and the best way to make a fence.  We also talk Busty Statues, cables, Krogan romance and get all giddy at meeting Nolan North. Cast: Mark Gibson, Darren Fotheringham & Dave Rose

Maybe GK doesn't understand exactly where the fun is in relation to mullets. Or perhaps we are discussing something quite different. FmLuder, gk128, and our very own player four - Binary667 get together on TPG to discuss games and stuff about games. Digital Firefly is out and about moving furniture. As usual we start off talking about the games we've been playing - but not before Luder brings up genitalia miscellanea again. - this time it is Krogan balls. And in stuff worth talking about we wonder who will have the bigger year - Sony or Microsoft. We pretty much decide it will be Nintendo. In the second segment we get into the big topic for the day - Games we love and games we love to hate. We go to gaming hell by getting into which game genre we want to die, which character we want to commit suicide and which game mechanic we wish would just croak it. Plus we go to gaming heaven and discuss all the things we love about games. The game genre we adore, the character we would give our left testicle for because we love them so much, and the game mechanic we can't live without.

In the last episode of the VS Node Podcast, Eddie, Jason, Tyler, Mike, and Matt thoroughly explored the Mass Effect franchise, but even that wasn't enough. Here on No Bounds, the guys discuss what Jason claims is the most importnt aspect of that virtual universe -- the fact that Krogans have four balls. Brace yourselves.... 00:00 - Tyler's former GameStop job and spineless store manager. 02:32 - Seth Green as Joker. Scars on Mass Effect 2 characters, wooing women, scars, tattoos, Agent Zero, and wild sex. 04:30 - Matt does nothing but play video games all day. 04:47 - Krogan balls. 08:33 - Elcor impressions. More Krogan balls. 11:43 - Mike's Mass Effect 2 boner. Jason's home menagerie. Gaming in 2010. Krogan balls. Music courtesy of Brian Schulman, 2007. Links: Eddie's Twitter - http://www.twitter.com/EddieInzauto Jason's Twitter - http://www.twitter.com/BigManfFanelli Tyler's Twitter - http://www.twitter.com/tyler_ca Mike's Twitter - http://www.twitter.com/_Murpho_ Matt's Twitter - http://www.twitter.com/mattamusprime --- Send in a voice message: https://anchor.fm/gamernode/message

Eddie, Jason, Tyler, Mike, and Matt share their experiences with online gaming and then move on to examine a reprehensible website that objectifies women just like strip clubs do. 00:00 - The Wii friend code system sucks. GN guys can't find it. Tyler wants to lie about the games he plays. 01:20 - A famous Tyler quote. His latest public shaming in Modern Warfare 2 on Xbox Live. 04:06 - Matt's French connection in Splinter Cell: Chaos Theory. 04:50 - Moms on Xbox Live. Eddie has no funny stories. 05:28 - Girls on Xbox Live. Gamecrush.com. Krogan balls. 12:19 - We know who's behind all this.... Music courtesy of Brian Schulman, 2007. Links: Eddie's Twitter - http://www.twitter.com/EddieInzauto Jason's Twitter - http://www.twitter.com/BigManfFanelli Tyler's Twitter - http://www.twitter.com/tyler_ca Mike's Twitter - http://www.twitter.com/_Murpho_ Matt's Twitter - http://www.twitter.com/mattamusprime --- Send in a voice message: https://anchor.fm/gamernode/message